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6 results on '"Bortone, Federica"'

2. Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization

Author

Iacomino, Nicola, primary, Scandiffio, Letizia, additional, Conforti, Fabio, additional, Salvi, Erika, additional, Tarasco, Maria Cristina, additional, Bortone, Federica, additional, Marcuzzo, Stefania, additional, Simoncini, Ornella, additional, Andreetta, Francesca, additional, Pistillo, Daniela, additional, Voulaz, Emanuele, additional, Alloisio, Marco, additional, Antozzi, Carlo, additional, Mantegazza, Renato, additional, De Pas, Tommaso Martino, additional, and Cavalcante, Paola, additional

Published
2023
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3. Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy

Author

Iacomino, Nicola, primary, Vanoli, Fiammetta, additional, Frangiamore, Rita, additional, Ballardini, Marta, additional, Scandiffio, Letizia, additional, Bortone, Federica, additional, Andreetta, Francesca, additional, Baggi, Fulvio, additional, Bernasconi, Pia, additional, Antozzi, Carlo, additional, Cavalcante, Paola, additional, and Mantegazza, Renato, additional

Published
2022
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5. MicroRNA signature associated with treatment response in myasthenia gravis: A further step towards precision medicine

Author

Cavalcante, Paola, primary, Mizrachi, Tehila, additional, Barzago, Claudia, additional, Scandiffio, Letizia, additional, Bortone, Federica, additional, Bonanno, Silvia, additional, Frangiamore, Rita, additional, Mantegazza, Renato, additional, Bernasconi, Pia, additional, Brenner, Talma, additional, Vaknin-Dembinsky, Adi, additional, and Antozzi, Carlo, additional

Published
2019
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6. Epstein-Barr Virus in Myasthenia Gravis : Key Contributing Factor Linking Innate Immunity with B-Cell-Mediated Autoimmunity

Author

Cavalcante, Paola, Scandiffio, Letizia, Mantegazza, Renato, Bortone, Federica, and Bernasconi, Pia

Subjects
Medical
Abstract

Epstein-Barr virus (EBV), a common human herpes virus latently infecting most of the world’s population with periodic reactivations, is the main environmental factor suspected to trigger and/or sustain autoimmunity by its ability to disrupt B-cell tolerance checkpoints. Myasthenia gravis (MG) is a prototypic autoimmune disorder, mostly caused by autoantibodies to acetylcholine receptor (AChR) of the neuromuscular junction, which cause muscle weakness and fatigability. Most patients display hyperplastic thymus, characterized by ectopic germinal center formation, chronic inflammation, exacerbated Toll-like receptor activation, and abnormal B-cell activation. After an overview on MG clinical features and intra-thymic pathogenesis, in the present chapter, we describe our main findings on EBV presence in MG thymuses, including hyperplastic and thymoma thymuses, in relationship with innate immunity activation and data from other autoimmune conditions. Our overall data strongly indicate a critical contribution of EBV to innate immune dysregulation and sustained B-cell-mediated autoimmune response in the pathological thymus of MG patients.

Published
2020

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