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10 results on '"Borrelli, Giovanna"'

4. The haematocrit and platelet target in polycythemia vera

Author

Di Nisio, Marcello, Barbui, Tiziano, Di Gennaro, Leonardo, Borrelli, Giovanna, Finazzi, Guido, Landolfi, Raffaele, Leone, Giuseppe, Marfisi, RosaMaria, Porreca, Ettore, Ruggeri, Marco, Rutjes, Anne W. S., Tognoni, Gianni, Vannucchi, Alessandro M., and Marchioli, Roberto

Published
2007

6. A GITIL Prospective Randomized Multicenter Phase III Study of High Dose Sequential Chemotherapy with Rituximab (R-HDS) and Autologous Transplantation (ASCT) of Peripheral Blood Stem Cells Versus CHOP and Rituximab Delivered Every 14 Days (R-CHOP-14) in High-Risk Patients with Diffuse Large B-Cell Lymphomas (DLBCL): Interim Analysis on Feasibility and Toxicity (Protocol R-HDS 0305).

Author

Cortelazzo, Sergio, primary, Billio, Atto, primary, Rambaldi, Alessandro, primary, Tarella, Corrado, primary, Majolino, Ingnazio, primary, Gianni, Alessandro M., primary, Corradini, Paolo, primary, Patti, Catterina, primary, Mirto, Salvo, primary, Borrelli, Giovanna, primary, and Marchioli9, Roberto, primary

Published
2007
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7. Efficacy of n-3 polyunsaturated fatty acids according to clinical characteristics of patients with recent myocardial infarction: insights from the GISSI-Prevenzione trial

Author

Marchioli, Roberto, primary, Marfisi, Rosa Maria, additional, Borrelli, Giovanna, additional, Chieffo, Carmelo, additional, Franzosi, Maria Grazia, additional, Levantesi, Giacomo, additional, Maggioni, Aldo Pietro, additional, Nicolosi, Gian Luigi, additional, Scarano, Marco, additional, Silletta, Maria Giuseppina, additional, Schweiger, Carlo, additional, Tavazzi, Luigi, additional, and Tognoni, Gianni, additional

Published
2007
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9. Epidemiological monitoring of psychological, neurological and sensorial handicaps in the 0-24 years population of the Abruzzo region (Italy). Preliminary results

Author

Madonna, Raffaella, primary, Valenti, Marco, additional, Borrelli, Giovanna, additional, Cerbo, Renato, additional, De Lellis, Manlio, additional, Sprovera, Giorgia, additional, Massaro, Marisa, additional, D'Alessandro, Antonella, additional, Marinucci, Maria Contina, additional, Tiberti, Sergio, additional, and Di Orio, Ferdinando, additional

Published
1998
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10. Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status

Author

Carobbio, Alessandra, Finazzi, Guido, Guerini, Vittoria, Spinelli, Orietta, Delaini, Federica, Marchioli, Roberto, Borrelli, Giovanna, Rambaldi, Alessandro, and Barbui, Tiziano

Abstract

Leukocytes contribute to the pathogenesis of thrombosis in essential thrombocythemia (ET) through recently discovered mechanisms of activation and interaction with platelets and endothelial cells. To evaluate whether an increased leukocyte count was associated with thrombosis and whether this effect can be modulated by therapy, we analyzed the clinical course of 439 patients with ET followed at the Ospedali Riuniti di Bergamo. The strength of the association was measured at diagnosis or before thrombotic events by multivariable analyses carried out using data at baseline as well as time-varying covariates. The results showed that (1) an increased leukocyte count at diagnosis was associated with thrombosis during follow-up (“baseline analysis,” relative risk [RR] 2.3, 95% confidence interval [CI] 1.4-3.9, P = .001); (2) hydroxyurea (HU) lowered leukocytosis and reduced the strength of the association between leukocytosis and thrombosis (“time-dependent analysis,” RR 1.6, 95% CI 0.9-2.0, not significant [NS]); (3) the association of leukocytosis and thrombosis was more evident in untreated low-risk patients (RR 2.7, 95% CI 1.2-6.4, P = .01) compared with HU-treated high-risk patients (RR 1.6, 95% CI 0.8-3.2, NS); and (4) the presence of JAK2 V617F was not identified as a risk factor for thrombosis during follow-up despite a significant association between the mutation and leukocytosis. We suggest validation of these findings in prospective clinical studies.

Published
2007
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