30 results on '"Borlée, Floor"'
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2. Attitude toward livestock farming does not influence the earlier observed association between proximity to goat farms and self-reported pneumonia
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Borlée, Floor, Yzermans, C. Joris, Oostwegel, Floor S. M., Schellevis, François, Heederik, Dick, and Smit, Lidwien A. M.
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- 2019
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3. Air Pollution from Livestock Farms Is Associated with Airway Obstruction in Neighboring Residents
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Borlée, Floor, Yzermans, Joris C., Aalders, Bernadette, Rooijackers, Jos, Krop, Esmeralda, Maassen, Catharina B. M., Schellevis, François, Brunekreef, Bert, Heederik, Dick, and Smit, Lidwien A. M.
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- 2017
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4. Spatial and temporal variation in endotoxin and PM10 concentrations in ambient air in a livestock dense area
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de Rooij, Myrna M.T., Heederik, Dick J.J., Borlée, Floor, Hoek, Gerard, and Wouters, Inge M.
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- 2017
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5. Acute respiratory effects of livestock-related air pollution in a panel of COPD patients
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van Kersen, Warner, Oldenwening, Marieke, Aalders, Bernadette, Bloemsma, Lizan D, Borlée, Floor, Heederik, Dick, Smit, Lidwien A M, One Health Microbieel, and One Health Microbieel
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Spirometry ,Evening ,010504 meteorology & atmospheric sciences ,air pollution ,Annoyance ,010501 environmental sciences ,01 natural sciences ,Pulmonary Disease, Chronic Obstructive ,Interquartile range ,Environmental health ,Animals ,Humans ,Medicine ,COPD ,lcsh:Environmental sciences ,Netherlands ,0105 earth and related environmental sciences ,General Environmental Science ,Morning ,lcsh:GE1-350 ,Air Pollutants ,medicine.diagnostic_test ,business.industry ,Environmental Exposure ,Odds ratio ,medicine.disease ,environmental epidemiology ,respiratory tract diseases ,livestock ,Particulate Matter ,business ,Environmental epidemiology - Abstract
Living close to livestock farms has been associated with increased symptoms in patients with chronic obstructive pulmonary disease (COPD). The causes of these effects are still poorly understood. This panel study attempts to assess the acute effects of livestock-related air pollution in patients with COPD living in an area with intensive livestock farming in the Netherlands.Between February 2015 and July 2016, 82 participants took spirometry measurements twice daily (morning and evening) during a 3-month period, resulting in 12,672 FEV1 and PEF records. Participants also kept a diary on respiratory symptoms as well as livestock-related odor annoyance. Daily average ammonia (NH3) (a proxy for livestock-related air pollution) and fine particulate matter (PM10) levels were collected from monitoring stations in the area. Lung function was analyzed as decrements of >10% and >20% from their median as well as absolute values. Self-reported odor annoyance was analyzed as a dichotomous variable. All analyses were done using generalized estimated equations. We adjusted for humidity, temperature, linear trend, and took multiple testing into account.We found an odds ratio of 1.14 95%CI [1.05; 1.25] for decrements >20% in morning FEV1 per interquartile range (12 µg/m3) increase in NH3 concentration (lag 2). Odor annoyance was negatively associated with evening PEF (−4.46 l/min 95%CI [−7.59; −1.33]). Sensitivity analyses showed a stronger effect in participants with worse baseline lung function. No associations with symptoms were found.Our results show acute effects of livestock-related air pollution on lung function in COPD patients living in close proximity to livestock farms. Keywords: Environmental epidemiology, Air pollution, Livestock, COPD
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- 2019
6. Acute respiratory effects of livestock-related air pollution in a panel of COPD patients
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van Kersen, Warner, primary, Oldenwening, Marieke, additional, Aalders, Bernadette, additional, Bloemsma, Lizan D., additional, Borlée, Floor, additional, Heederik, Dick, additional, and Smit, Lidwien A.M., additional
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- 2020
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7. Comorbidity and coexisting symptoms and infections presented in general practice by COPD patients: Does livestock density in the residential environment play a role?
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Baliatsas, Christos, Borlée, Floor, van Dijk, Christel E, van der Star, Baukje, Zock, Jan-Paul, Smit, Lidwien A M, Spreeuwenberg, Peter, Heederik, Dick, Yzermans, C Joris, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA
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Male ,medicine.medical_specialty ,Farms ,Livestock ,Epidemiology ,Coronacrisis-Taverne ,Comorbidity ,Infections ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Residence Characteristics ,Environmental health ,medicine ,Animals ,Humans ,COPD ,030212 general & internal medicine ,Depression (differential diagnoses) ,Aged ,Asthma ,Aged, 80 and over ,Respiratory tract infections ,business.industry ,Public Health, Environmental and Occupational Health ,Environmental Exposure ,Environmental exposure ,Middle Aged ,medicine.disease ,Pneumonia ,030228 respiratory system ,Physical therapy ,Female ,General practice ,business - Abstract
Objectives Patients with chronic obstructive pulmonary disease (COPD) constitute a potentially susceptible group towards environmental exposures such as livestock farm emissions, given their compromised respiratory health status. The primary aim of this study was to examine the association between livestock exposure and comorbidities and coexisting symptoms and infections in COPD patients. Methods Data were collected from 1828 COPD patients (without co-occurring asthma) registered in 23 general practices and living in a rural area with a high livestock density. Prevalence of comorbid diseases/disorders and coexisting symptoms/infections were based on electronic health records from the year 2012. Various indicators of individual exposure to livestock were estimated based on residential addresses, using a geographic information system. Results At least one comorbid disorder was present in 69% of the COPD patients (especially cardiac disorders and depression, while 49% had at least one coexisting symptom and/or infection (especially upper respiratory tract infections, respiratory symptoms and pneumonia). Half of the COPD-patients resided less than 500 m of the nearest farm. Some positive as well as inverse associations were found between the examined outcomes and exposure estimates, although not consistent. Conclusions Despite the high prevalence of coexisting chronic and acute conditions presented in primary care by in COPD patients, this investigation found no convincing evidence for an association with livestock exposure estimates. There is a need for a replication of the present findings in studies with a longitudinal design, on different groups of potentially susceptible patients. Future research should also elucidate the biological plausibility of possible protective effects of exposure.
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- 2017
8. Pneumonia risk of people living close to goat and poultry farms – Taking GPS derived mobility patterns into account
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Klous, Gijs, Smit, Lidwien A M, Freidl, Gudrun S, Borlée, Floor, van der Hoek, Wim, IJzermans, C Joris, Kretzschmar, Mirjam E. E., Heederik, Dick J J, Coutinho, Roel A, Huss, Anke, One Health Microbieel, LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, One Health Chemisch, dIRAS RA-I&I RA, dIRAS RA-2, One Health Microbieel, LS IRAS EEPI GRA (Gezh.risico-analyse), Dep IRAS, One Health Chemisch, dIRAS RA-I&I RA, and dIRAS RA-2
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Risk ,Rural Population ,0301 basic medicine ,Farms ,Poultry ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Environmental Science(all) ,Environmental health ,medicine ,Animals ,Humans ,030212 general & internal medicine ,lcsh:Environmental sciences ,Netherlands ,General Environmental Science ,lcsh:GE1-350 ,business.industry ,Goats ,Incidence (epidemiology) ,Pneumonia ,Poultry farming ,medicine.disease ,030104 developmental biology ,Geography ,Increased risk ,Cohort ,business ,Pneumonia (non-human) ,Medical doctor ,Cohort study - Abstract
We previously observed an increased incidence of pneumonia in persons living near goat and poultry farms, using animal presence around the home to define exposure. However, it is unclear to what extent individual mobility and time spent outdoors close to home contributes to this increased risk. Therefore, the aim of the current study was to investigate the role of mobility patterns and time spent outdoors in the vicinity of goat or poultry farms in relation to pneumonia risk. In a rural Dutch cohort, 941 members logged their mobility using GPS trackers for 7 days. Pneumonia was diagnosed in 83 subjects (participants reported that pneumonia had been diagnosed by a medical doctor, or recorded in EMR from general practitioners, 2011-2014). We used logistic regression to evaluate pneumonia-risk by presence of goat farms within 500 and 1000 m around the home and around GPS-tracks (only non-motorised mobility), also we evaluated whether more time spent outdoors increased pneumonia-risks. We observed a clearly increased risk of pneumonia among people living in close proximity to goat farms, ORs increased with closer distances of homes to farms (500 m: 6.2 (95% CI 2.2-16.5) 1000 m: 2.5 (1.4-4.3)) The risk increased for individuals who spent more time outdoors close to home, but only if homes were close to goat farms (within 500 m and often outdoors: 12.7 (3.6-45.4) less often: 2.0 (0.3-9.2), no goat farms and often outdoors: 1.0 (0.6-1.6)). For poultry we found no increased risks. Pneumonia-risks increased when people lived near goat farms, especially when they spent more time outdoors, mobility does not seem to add to these risks.
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- 2018
9. Livestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands
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Freidl, Gudrun S, Spruijt, Ineke T, Borlée, Floor, Smit, Lidwien A M, van Gageldonk-Lafeber, Arianne B, Heederik, Dick J J, Yzermans, Joris, van Dijk, Christel E, Maassen, Catharina B M, van der Hoek, Wim, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA
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Bacterial Diseases ,Male ,Veterinary medicine ,Pulmonology ,lcsh:Medicine ,Pathology and Laboratory Medicine ,Poultry ,0302 clinical medicine ,Risk Factors ,Medicine and Health Sciences ,Electronic Health Records ,030212 general & internal medicine ,Animal Husbandry ,lcsh:Science ,Netherlands ,Mammals ,Multidisciplinary ,biology ,Goats ,Medical record ,Agriculture ,Ruminants ,Animal husbandry ,Poultry farming ,Middle Aged ,Bacterial Pathogens ,Infectious Diseases ,Medical Microbiology ,Coxiella burnetii ,Animals, Domestic ,Vertebrates ,Livestock ,Female ,Pathogens ,Q Fever ,Research Article ,Adult ,Farms ,Q fever ,Microbiology ,Birds ,03 medical and health sciences ,Young Adult ,Environmental health ,medicine ,Animals ,Humans ,Microbial Pathogens ,Aged ,Sheep ,business.industry ,lcsh:R ,Organisms ,Biology and Life Sciences ,Odds ratio ,Pneumonia ,medicine.disease ,biology.organism_classification ,030228 respiratory system ,Amniotes ,lcsh:Q ,business - Abstract
Previous research conducted in 2009 found a significant positive association between pneumonia in humans and living close to goat and poultry farms. However, as this result might have been affected by a large goat-related Q fever epidemic, the aim of the current study was to re-evaluate this association, now that the Q-fever epidemic had ended. In 2014/15, 2,494 adults (aged 20–72 years) living in a livestock-dense area in the Netherlands participated in a medical examination and completed a questionnaire on respiratory health, lifestyle and other items. We retrieved additional information for 2,426/2,494 (97%) participants from electronic medical records (EMR) from general practitioners. The outcome was self-reported, physician-diagnosed pneumonia or pneumonia recorded in the EMR in the previous three years. Livestock license data was used to determine exposure to livestock. We quantified associations between livestock exposures and pneumonia using odds ratios adjusted for participant characteristics and comorbidities (aOR). The three-year cumulative frequency of pneumonia was 186/2,426 (7.7%). Residents within 2,000m of a farm with at least 50 goats had an increased risk of pneumonia, which increased the closer they lived to the farm (2,000m aOR 1.9, 95% CI 1.4–2.6; 500m aOR 4.4, 95% CI 2.0–9.8). We found no significant associations between exposure to other farm animals and pneumonia. However, when conducting sensitivity analyses using pneumonia outcome based on EMR only, we found a weak but statistically significant association with presence of a poultry farm within 1,000m (aOR: 1.7, 95% CI 1.1–2.7). Living close to goat and poultry farms still constitute risk factors for pneumonia. Individuals with pneumonia were not more often seropositive for Coxiella burnetii, indicating that results are not explained by Q fever. We strongly recommend identification of pneumonia causes by the use of molecular diagnostics and investigating the role of non-infectious agents such as particulate matter or endotoxins.
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- 2018
10. Acute respiratory effects of livestock related air pollution on a panel of COPD patients
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van Kersen, Warner, primary, Oldenwening, Marieke, additional, Aalders, Bernadette, additional, Bloemsma, Lizan D., additional, Borlée, Floor, additional, Heederik, Dick, additional, and Smit, Lidwien A.M., additional
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- 2019
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11. Remarkable spatial variation in the seroprevalence of Coxiella burnetii after a large Q fever epidemic
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Pijnacker, Roan, Reimerink, Johan H J, Smit, Lidwien A M, van Gageldonk-Lafeber, Arianne B, Zock, Jan-Paul, Borlée, Floor, Yzermans, C Joris, Heederik, Dick J J, Maassen, Catharina B M, van der Hoek, Wim, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA
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Adult ,0301 basic medicine ,Veterinary medicine ,Disease reservoir ,Livestock ,Cross-sectional study ,030106 microbiology ,Population ,Seroprevalence ,Q fever ,lcsh:Infectious and parasitic diseases ,Zoonosis ,03 medical and health sciences ,0302 clinical medicine ,Seroepidemiologic Studies ,Prevalence ,medicine ,Animals ,Humans ,lcsh:RC109-216 ,030212 general & internal medicine ,Epidemics ,education ,Aged ,Disease Reservoirs ,Netherlands ,education.field_of_study ,biology ,Goats ,Incidence ,Incidence (epidemiology) ,Middle Aged ,bacterial infections and mycoses ,medicine.disease ,Coxiella burnetii ,biology.organism_classification ,Antibodies, Bacterial ,Virology ,Dairying ,Cross-Sectional Studies ,Infectious Diseases ,Risk factors ,bacteria ,Q Fever ,Research Article - Abstract
Background Prior to the 2007–2010 Q fever epidemic in the Netherlands, the seroprevalence of antibodies against Coxiella burnetii in the general population was 1.5%, which is low compared to other countries. We aimed to determine the seroprevalence after the Q fever epidemic among people living in the affected area, compare the seroprevalence with the incidence of Q fever notifications during the 2007–2010 Q fever epidemic, and to identify farm exposures associated with having antibodies against C. burnetii. Methods During the period March 2014–February 2015, residents aged 18–70 years from two provinces were invited by general practitioners to complete a questionnaire on their symptoms and personal characteristics and to submit a blood sample. We used the mandatory provincial database of livestock licences to calculate distance to farms/farm animals for each participant. To compare ELISA-positive participants for C. burnetii antibodies with those who were negative, we calculated prevalence ratios (PR) using binominal regression. We compared the C. burnetii seroprevalence in the period March 2014–February 2015 with the incidence of Q fever notifications during the 2007–2010 Q fever epidemic at municipal level by calculating the Spearman correlation coefficient. Results Of the 2296 participants (response rate: 34%), 6.1% (n = 139, 95% CI 5.1–7.1%) had C. burnetii antibodies (range in municipalities: 1.7–14.1%). C. burnetii seroprevalence was higher in individuals living within 1000 m of goat farms (PR 3.0; 95% CI 1.4–6.4) or within 1000 m of > 50 goats (PR 1.9; 95% CI 1.2–3.0). Seroprevalence increased with decreasing distance to the closest goat farm that was infected during the epidemic years ( 2000 reference group). There was no significant correlation between C. burnetii seroprevalence and Q fever incidence during the 2007–2010 epidemic (r s = 0.42, p = 0.156). Conclusions Results showed a remarkable spatial variation in C. burnetii seroprevalence in a relatively small livestock dense area. It confirms previous evidence that the Q fever epidemic was primarily the result of airborne C. burnetii transmission from Q fever affected goat farms.
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- 2017
12. Health conditions in rural areas with high livestock density: Analysis of seven consecutive years
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van Dijk, Christel E, Zock, Jan-Paul, Baliatsas, Christos, Smit, Lidwien A M, Borlée, Floor, Spreeuwenberg, Peter, Heederik, Dick, Yzermans, C Joris, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, dIRAS RA-2, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, and dIRAS RA-2
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Adult ,Male ,Rural Population ,medicine.medical_specialty ,Chronic bronchitis ,Livestock ,Epidemiology ,Health, Toxicology and Mutagenesis ,Coronacrisis-Taverne ,Rural Health ,010501 environmental sciences ,Toxicology ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Environmental health ,medicine ,Prevalence ,Animals ,Humans ,030212 general & internal medicine ,Geography, Medical ,0105 earth and related environmental sciences ,Asthma ,Netherlands ,Respiratory tract infections ,business.industry ,Public health ,Incidence (epidemiology) ,Respiratory health ,General Medicine ,Environmental exposure ,Middle Aged ,medicine.disease ,Pollution ,Logistic Models ,Case-Control Studies ,Bronchitis ,Female ,business ,General practice - Abstract
Previous studies investigating health conditions of individuals living near livestock farms generally assessed short time windows. We aimed to take time-specific differences into account and to compare the prevalence of various health conditions over seven consecutive years. The sample consisted of 156,690 individuals registered in 33 general practices in a (rural) area with a high livestock density and 101,015 patients from 23 practices in other (control) areas in the Netherlands. Prevalence of health conditions were assessed using 2007-2013 electronic health record (EHR) data. Two methods were employed to assess exposure: 1) Comparisons between the study and control areas in relation to health problems, 2) Use of individual estimates of livestock exposure (in the study area) based on Geographic Information System (GIS) data. A higher prevalence of chronic bronchitis/bronchiectasis, lower respiratory tract infections and vertiginous syndrome and lower prevalence of respiratory symptoms and emphysema/COPD was found in the study area compared with the control area. A shorter distance to the nearest farm was associated with a lower prevalence of upper respiratory tract infections, respiratory symptoms, asthma, COPD/emphysema, allergic rhinitis, depression, eczema, vertiginous syndrome, dizziness and gastrointestinal infections. Especially exposure to cattle was associated with less health conditions. Living within 500m of mink farms was associated with increased chronic enteritis/ulcerative colitis. Livestock-related exposures did not seem to be an environmental risk factor for the occurrence of health conditions. Nevertheless, lower respiratory tract infections, chronic bronchitis and vertiginous syndrome were more common in the area with a high livestock density. The association between exposure to minks and chronic enteritis/ulcerative colitis remains to be elucidated.
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- 2017
13. Attitude Towards Livestock Farming Does Not Influence Associations between Farm Proximity and Respiratory Health in a Rural Population Study
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Borlée, Floor, primary, Yzermans, Joris, additional, Oostwegel, Floor, additional, Schellevis, Francois, additional, Heederik, Dick, additional, and Smit, Lidwien, additional
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- 2018
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14. Risk of exacerbations in COPD and asthma patients living in the neighbourhood of livestock farms: Observational study using longitudinal data
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van Dijk, Christel E, Garcia-Aymerich, Judith, Carsin, Anne-Elie, Smit, Lidwien A M, Borlée, Floor, Heederik, Dick J, Donker, Gé A, Yzermans, C Joris, Zock, Jan-Paul, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA
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Adult ,Male ,Risk ,medicine.medical_specialty ,Farms ,Livestock ,Exacerbation ,Adolescent ,Coronacrisis-Taverne ,Exacerbations ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,Young Adult ,0302 clinical medicine ,Environmental health ,medicine ,Animals ,Humans ,COPD ,Respiratory function ,030212 general & internal medicine ,Risk factor ,Intensive care medicine ,Asthma ,Aged ,Netherlands ,Aged, 80 and over ,business.industry ,Public Health, Environmental and Occupational Health ,Environmental exposure ,Middle Aged ,medicine.disease ,respiratory tract diseases ,030228 respiratory system ,Observational study ,Female ,Rural area ,business - Abstract
Objective Living in an area with a high density of livestock farms has been associated with adverse respiratory health effects in some studies. As patients with COPD and asthma already have a compromised respiratory function and chronic airway inflammation, they are expected to be at increased risk for adverse respiratory health effects. The objective of this study was to assess the association between livestock exposure and exacerbations in COPD and asthma. Methods 899 COPD and 2546 asthma patients from 15 general practices in a rural area with a high livestock density and 933 COPD and 2310 asthma patients from 15 practices in a control area in the Netherlands were included. Occurrence of exacerbations was based on the pharmaceutical treatment of exacerbations in COPD and asthma patients using 2006–2012 prescription data of electronic medical records. Farm exposure was assessed by comparing the study area with the control area, and with individual exposure estimates in the study area using Geographic Information System data. Results The exacerbation rate was higher in the study area compared with the control area in COPD (IRR: 1.28; 95%CI: 1.06–1.55), but not in asthma patients (IRR: 0.87; 95%CI: 0.72–1.05). In general, individual exposure estimates in the study area were not associated with exacerbations. COPD patients living within a 500 m radius of up to12,499 chickens had a 36% higher exacerbation rate (IRR: 1.36; 95%CI: 1.03–1.79). Conclusions Living in an area with a high livestock density is a risk factor for exacerbations in COPD patients. The environmental exposure responsible for this increased risk remains to be elucidated.
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- 2016
15. Short-term effects of air pollution from livestock farms on lung function in patients with COPD
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Smit, Lidwien A.M., primary, van Dijk, Tomas, additional, Oldenwening, Marieke, additional, Aalders, Bernadette, additional, Bloemsma, Lizan D., additional, Borlée, Floor, additional, and Heederik, Dick, additional
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- 2017
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16. Mobility assessment of a rural population in the Netherlands using GPS measurements
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Klous, Gijs, primary, Smit, Lidwien A. M., additional, Borlée, Floor, additional, Coutinho, Roel A., additional, Kretzschmar, Mirjam E. E., additional, Heederik, Dick J. J., additional, and Huss, Anke, additional
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- 2017
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17. Livestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands
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Freidl, Gudrun S., primary, Spruijt, Ineke T., additional, Borlée, Floor, additional, Smit, Lidwien A. M., additional, van Gageldonk-Lafeber, Arianne B., additional, Heederik, Dick J. J., additional, Yzermans, Joris, additional, van Dijk, Christel E., additional, Maassen, Catharina B. M., additional, and van der Hoek, Wim, additional
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- 2017
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18. Spirometry, questionnaire and electronic medical record based COPD in a population survey: Comparing prevalence, level of agreement and associations with potential risk factors
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Borlée, Floor, primary, Yzermans, C. Joris, additional, Krop, Esmeralda, additional, Aalders, Bernadette, additional, Rooijackers, Jos, additional, Zock, Jan-Paul, additional, van Dijk, Christel E., additional, Maassen, Catharina B. M., additional, Schellevis, François, additional, Heederik, Dick, additional, and Smit, Lidwien A. M., additional
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- 2017
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19. Hepatitis E virus seroprevalence among the general population in a livestock-dense area in the Netherlands: a cross-sectional population-based serological survey
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van Gageldonk-Lafeber, Arianne B., primary, van der Hoek, Wim, additional, Borlée, Floor, additional, Heederik, Dick J. J., additional, Mooi, Sofie H., additional, Maassen, Catharina B. M., additional, Yzermans, C. Joris, additional, Rockx, Barry, additional, Smit, Lidwien A. M., additional, and Reimerink, Johan H. J., additional
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- 2017
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20. 'Hotspots' of livestock farms may influence lung function of neighboring residents
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Borlée, Floor, primary, Yzermans, C. Joris, additional, Aalders, Bernadette, additional, Rooijackers, Jos, additional, Krop, Esmeralda, additional, Maassen, Kitty, additional, Schellevis, Francois, additional, Heederik, Dick, additional, and Smit, Lidwien A.M., additional
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- 2016
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21. Residential proximity to livestock farms reduces the risk of atopic sensitization
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Borlée*, Floor, primary, Yzermans, Joris, additional, Krop, Esmeralda, additional, Maassen, Kitty, additional, Schellevis, Francois, additional, Heederik, Dick, additional, and Smit, Lidwien, additional
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- 2016
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22. 'Hotspots' of livestock farms may influence lung function of neighboring residents
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Borlée*, Floor, primary, Yzermans, Joris, additional, Aalders, Bernadette, additional, Rooijackers, Jos, additional, Krop, Esmeralda, additional, Maassen, Kitty, additional, Schellevis, Francios, additional, Heederik, Dick, additional, and Smit, Lidwien, additional
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- 2016
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23. Detection of Coxiella burnetii in Ambient Air after a Large Q Fever Outbreak
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de Rooij, Myrna M. T., primary, Borlée, Floor, additional, Smit, Lidwien A. M., additional, de Bruin, Arnout, additional, Janse, Ingmar, additional, Heederik, Dick J. J., additional, and Wouters, Inge M., additional
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- 2016
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24. Increased respiratory symptoms in COPD patients living in the vicinity of livestock farms
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Borlée, Floor, Yzermans, C Joris, van Dijk, Christel E, Heederik, Dick, Smit, Lidwien A M, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA-SIB, and LS IRAS EEPI GRA (Gezh.risico-analyse)
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Pulmonary and Respiratory Medicine ,Adult ,Male ,Rural Population ,medicine.medical_specialty ,Livestock ,Cross-sectional study ,animal diseases ,Coronacrisis-Taverne ,Severity of Illness Index ,Pulmonary Disease, Chronic Obstructive ,Residence Characteristics ,Risk Factors ,Environmental health ,Surveys and Questionnaires ,medicine ,Prevalence ,Animals ,Humans ,Asthma ,Aged ,Netherlands ,Response rate (survey) ,COPD ,business.industry ,Medical record ,Smoking ,Agriculture ,Environmental exposure ,Environmental Exposure ,Middle Aged ,medicine.disease ,Rhinitis, Allergic ,Cross-Sectional Studies ,Quartile ,Nonlinear Dynamics ,Physical therapy ,Disease Progression ,Female ,business - Abstract
Several studies have investigated the effect of livestock farm emissions on the respiratory health of local residents, but results are inconsistent. This study aims to explore associations between the presence of livestock farms and respiratory health in an area of high-density livestock farming in the Netherlands. We focused especially on associations between farm exposures and respiratory symptoms within subgroups of potentially susceptible patients with a pre-existing lung disease.In total, 14 875 adults (response rate 53.4%) completed a questionnaire concerning respiratory health, smoking habits and personal characteristics. Different indicators of livestock farm exposures relative to the home address were computed using a geographic information system.Prevalence of chronic obstructive pulmonary disease (COPD) and asthma was lower among residents living within 100 m of a farm (OR 0.47, 95% CI 0.24–0.91 and OR 0.65, 95% CI 0.45–0.93, respectively). However, >11 farms in 1000 m compared to fewer than four farms in 1000 m (fourth quartileversusfirst quartile) was associated with wheezing among COPD patients (OR 1.71, 95% CI 1.01–2.89). Using general practitioners' electronic medical records, we demonstrated that selection bias did not affect the observed associations.Our data suggest a protective effect of livestock farm emissions on the respiratory health of residents. Nonetheless, COPD patients living near livestock farms reported more respiratory symptoms, suggesting an increased risk of exacerbations.
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- 2015
25. Risk of exacerbations in COPD and asthma patients living in the neighbourhood of livestock farms
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Van Dijk, Christel, primary, Garcia-Aymerich, Judith, additional, Carsin, Anne-Elie, additional, Smit, Lidwien, additional, Borlée, Floor, additional, Heederik, Dick, additional, Donker, Gé, additional, Yzermans, Joris, additional, and Zock, Jan-Paul, additional
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- 2015
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26. Detection of Coxiella burnetii DNA in Inhalable Airborne Dust Samples from Goat Farms after Mandatory Culling
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Hogerwerf, Lenny, primary, Borlée, Floor, additional, Still, Kelly, additional, Heederik, Dick, additional, van Rotterdam, Bart, additional, de Bruin, Arnout, additional, Nielen, Mirjam, additional, and Wouters, Inge M., additional
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- 2012
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27. Hepatitis E virus seroprevalence among the general population in a livestock-dense area in the Netherlands: a cross-sectional population-based serological survey
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van Gageldonk-Lafeber, Arianne B, van der Hoek, Wim, Borlée, Floor, Heederik, Dick J J, Mooi, Sofie H, Maassen, Catharina B M, Yzermans, C Joris, Rockx, Barry, Smit, Lidwien A M, Reimerink, Johan H J, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA
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Adult ,Male ,Rural Population ,0301 basic medicine ,Veterinary medicine ,Livestock ,Swine ,Population ,Seroprevalence ,medicine.disease_cause ,law.invention ,Serology ,Young Adult ,03 medical and health sciences ,Hepatitis E virus ,Risk Factors ,Seroepidemiologic Studies ,law ,Surveys and Questionnaires ,Environmental health ,Zoonoses ,Animals ,Humans ,Medicine ,Risk factor ,education ,Feces ,Aged ,Netherlands ,education.field_of_study ,Chi-Square Distribution ,business.industry ,Middle Aged ,Environmental exposure ,Hepatitis E ,Cross-Sectional Studies ,030104 developmental biology ,Transmission (mechanics) ,Infectious Diseases ,Female ,business ,Research Article - Abstract
BACKGROUND: Recent serological studies indicate that hepatitis E virus (HEV) is endemic in industrialised countries. The increasing trend in the number of autochthonous cases of HEV genotype 3 in Western European countries, stresses the importance to get insight in the exact routes of exposure. Pigs are the main animal reservoir, and zoonotic food-borne transmission of HEV is proven. However, infected pigs can excrete large amounts of virus via their faeces enabling environmental transmission of HEV to humans. This might pose a risk for of neighbouring residents of livestock farming. METHODS: Within a large study on the health of people living in the vicinity of livestock farming we performed a cross-sectional population-based serological survey among 2,494 non-farming adults from the general population in a livestock-dense area in the south of the Netherlands. Participants completed risk factor questionnaires and blood samples of 2,422 subjects (median age 58 years, range 20-72) were tested for anti-HEV IgG using an enzyme immune assay (Wantai). The aim of this study was to determine the HEV seroprevalence and to assess whether seropositivity in adults was associated with living in the vicinity of pig farms. RESULTS: The average seroprevalence of HEV was 28.7% (95% CI: 26.9-30.5). Determinants associated with an increased risk for HEV seropositivity were male gender and low level of education. There was a clear trend of increasing prevalence with increasing age (Chi-square test for linear trend, X(2) = 83.1; p
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28. Pneumonia risk of people living close to goat and poultry farms - Taking GPS derived mobility patterns into account.
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Klous G, Smit LAM, Freidl GS, Borlée F, van der Hoek W, IJzermans CJ, Kretzschmar MEE, Heederik DJJ, Coutinho RA, and Huss A
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- Animals, Cohort Studies, Humans, Netherlands epidemiology, Risk, Rural Population statistics & numerical data, Farms statistics & numerical data, Goats, Pneumonia epidemiology, Poultry
- Abstract
We previously observed an increased incidence of pneumonia in persons living near goat and poultry farms, using animal presence around the home to define exposure. However, it is unclear to what extent individual mobility and time spent outdoors close to home contributes to this increased risk. Therefore, the aim of the current study was to investigate the role of mobility patterns and time spent outdoors in the vicinity of goat or poultry farms in relation to pneumonia risk. In a rural Dutch cohort, 941 members logged their mobility using GPS trackers for 7 days. Pneumonia was diagnosed in 83 subjects (participants reported that pneumonia had been diagnosed by a medical doctor, or recorded in EMR from general practitioners, 2011-2014). We used logistic regression to evaluate pneumonia-risk by presence of goat farms within 500 and 1000 m around the home and around GPS-tracks (only non-motorised mobility), also we evaluated whether more time spent outdoors increased pneumonia-risks. We observed a clearly increased risk of pneumonia among people living in close proximity to goat farms, ORs increased with closer distances of homes to farms (500 m: 6.2 (95% CI 2.2-16.5) 1000 m: 2.5 (1.4-4.3)) The risk increased for individuals who spent more time outdoors close to home, but only if homes were close to goat farms (within 500 m and often outdoors: 12.7 (3.6-45.4) less often: 2.0 (0.3-9.2), no goat farms and often outdoors: 1.0 (0.6-1.6)). For poultry we found no increased risks. Pneumonia-risks increased when people lived near goat farms, especially when they spent more time outdoors, mobility does not seem to add to these risks., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
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- 2018
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29. Health conditions in rural areas with high livestock density: Analysis of seven consecutive years.
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van Dijk CE, Zock JP, Baliatsas C, Smit LAM, Borlée F, Spreeuwenberg P, Heederik D, and Yzermans CJ
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- Adult, Animals, Case-Control Studies, Female, Geography, Medical trends, Humans, Logistic Models, Male, Middle Aged, Netherlands, Prevalence, Rural Health trends, Rural Population trends, Geography, Medical statistics & numerical data, Livestock, Rural Health statistics & numerical data, Rural Population statistics & numerical data
- Abstract
Previous studies investigating health conditions of individuals living near livestock farms generally assessed short time windows. We aimed to take time-specific differences into account and to compare the prevalence of various health conditions over seven consecutive years. The sample consisted of 156,690 individuals registered in 33 general practices in a (rural) area with a high livestock density and 101,015 patients from 23 practices in other (control) areas in the Netherlands. Prevalence of health conditions were assessed using 2007-2013 electronic health record (EHR) data. Two methods were employed to assess exposure: 1) Comparisons between the study and control areas in relation to health problems, 2) Use of individual estimates of livestock exposure (in the study area) based on Geographic Information System (GIS) data. A higher prevalence of chronic bronchitis/bronchiectasis, lower respiratory tract infections and vertiginous syndrome and lower prevalence of respiratory symptoms and emphysema/COPD was found in the study area compared with the control area. A shorter distance to the nearest farm was associated with a lower prevalence of upper respiratory tract infections, respiratory symptoms, asthma, COPD/emphysema, allergic rhinitis, depression, eczema, vertiginous syndrome, dizziness and gastrointestinal infections. Especially exposure to cattle was associated with less health conditions. Living within 500m of mink farms was associated with increased chronic enteritis/ulcerative colitis. Livestock-related exposures did not seem to be an environmental risk factor for the occurrence of health conditions. Nevertheless, lower respiratory tract infections, chronic bronchitis and vertiginous syndrome were more common in the area with a high livestock density. The association between exposure to minks and chronic enteritis/ulcerative colitis remains to be elucidated., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
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- 2017
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30. Risk of exacerbations in COPD and asthma patients living in the neighbourhood of livestock farms: Observational study using longitudinal data.
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van Dijk CE, Garcia-Aymerich J, Carsin AE, Smit LA, Borlée F, Heederik DJ, Donker GA, Yzermans CJ, and Zock JP
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- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Female, Humans, Male, Middle Aged, Netherlands epidemiology, Risk, Young Adult, Asthma epidemiology, Environmental Exposure adverse effects, Farms, Livestock, Pulmonary Disease, Chronic Obstructive epidemiology
- Abstract
Objective: Living in an area with a high density of livestock farms has been associated with adverse respiratory health effects in some studies. As patients with COPD and asthma already have a compromised respiratory function and chronic airway inflammation, they are expected to be at increased risk for adverse respiratory health effects. The objective of this study was to assess the association between livestock exposure and exacerbations in COPD and asthma., Methods: 899 COPD and 2546 asthma patients from 15 general practices in a rural area with a high livestock density and 933 COPD and 2310 asthma patients from 15 practices in a control area in the Netherlands were included. Occurrence of exacerbations was based on the pharmaceutical treatment of exacerbations in COPD and asthma patients using 2006-2012 prescription data of electronic medical records. Farm exposure was assessed by comparing the study area with the control area, and with individual exposure estimates in the study area using Geographic Information System data., Results: The exacerbation rate was higher in the study area compared with the control area in COPD (IRR: 1.28; 95%CI: 1.06-1.55), but not in asthma patients (IRR: 0.87; 95%CI: 0.72-1.05). In general, individual exposure estimates in the study area were not associated with exacerbations. COPD patients living within a 500m radius of up to12,499 chickens had a 36% higher exacerbation rate (IRR: 1.36; 95%CI: 1.03-1.79)., Conclusions: Living in an area with a high livestock density is a risk factor for exacerbations in COPD patients. The environmental exposure responsible for this increased risk remains to be elucidated., (Copyright © 2016 Elsevier GmbH. All rights reserved.)
- Published
- 2016
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