Search

Your search keyword '"Borkunov, Gleb V."' showing total 9 results
Start Over Author "Borkunov, Gleb V."
9 results on '"Borkunov, Gleb V."'

2. New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy

Author

Borkunov, Gleb V., Leshchenko, Elena V., Berdyshev, Dmitrii V., Popov, Roman S., Chingizova, Ekaterina A., Shlyk, Nadezhda P., Gerasimenko, Andrey V., Kirichuk, Natalya N., Khudyakova, Yuliya V., Chausova, Viktoria E., Antonov, Alexandr S., Kalinovsky, Anatoly I., Chingizov, Artur R., Yurchenko, Ekaterina A., Isaeva, Marina P., and Yurchenko, Anton N.

Published
2024
Full Text
View/download PDF

3. New Zosteropenillines and Pallidopenillines from the Seagrass-Derived Fungus Penicillium yezoense KMM 4679.

Author

Leshchenko, Elena V., Chingizova, Ekaterina A., Antonov, Alexandr S., Shlyk, Nadezhda P., Borkunov, Gleb V., Berdyshev, Dmitrii V., Chausova, Viktoria E., Kirichuk, Natalya N., Khudyakova, Yuliya V., Chingizov, Artur R., Kalinovsky, Anatoly I., Popov, Roman S., Kim, Natalya Yu., Chadova, Ksenia A., Yurchenko, Ekaterina A., Isaeva, Marina P., and Yurchenko, Anton N.

Abstract

Ten new decalin polyketides, zosteropenilline M (1), 11-epi-8-hydroxyzosteropenilline M (2), zosteropenilline N (3), 8-hydroxyzosteropenilline G (4), zosteropenilline O (5), zosteropenilline P (6), zosteropenilline Q (7), 13-dehydroxypallidopenilline A (8), zosteropenilline R (9) and zosteropenilline S (10), together with known zosteropenillines G (11) and J (12), pallidopenilline A (13) and 1-acetylpallidopenilline A (14), were isolated from the ethyl acetate extract of the fungus Penicillium yezoense KMM 4679 associated with the seagrass Zostera marina. The structures of isolated compounds were established based on spectroscopic methods. The absolute configurations of zosteropenilline Q (7) and zosteropenilline S (10) were determined using a combination of the modified Mosher's method and ROESY data. The absolute configurations of zosteropenilline M (1) and zosteropenilline N (3) were determined using time-dependent density functional theory (TD-DFT) calculations of the ECD spectra. A biogenetic pathway for compounds 1–14 is proposed. The antimicrobial, cytotoxic and cytoprotective activities of the isolated compounds were also studied. The significant cytoprotective effects of the new zosteropenilline M and zosteropenillines O and R were found in a cobalt chloride (II) mimic in in vitro hypoxia in HEK-293 cells. 1-Acetylpallidopenilline A (14) exhibited high inhibition of human breast cancer MCF-7 cell colony formation with IC50 of 0.66 µM and its anticancer effect was reduced when MCF-7 cells were pretreated with 4-hydroxitamoxifen. Thus, we propose 1-acetylpallidopenilline A as a new xenoestrogen with significant activity against breast cancer. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Bioactive Polyketides from the Natural Complex of the Sea Urchin-Associated Fungi Penicillium sajarovii KMM 4718 and Aspergillus protuberus KMM 4747

Author

Leshchenko, Elena V., primary, Berdyshev, Dmitrii V., additional, Yurchenko, Ekaterina A., additional, Antonov, Alexandr S., additional, Borkunov, Gleb V., additional, Kirichuk, Natalya N., additional, Chausova, Viktoria E., additional, Kalinovskiy, Anatoly I., additional, Popov, Roman S., additional, Khudyakova, Yuliya V., additional, Chingizova, Ekaterina A., additional, Chingizov, Artur R., additional, Isaeva, Marina P., additional, and Yurchenko, Anton N., additional

Published
2023
Full Text
View/download PDF

5. New Bioactive β-Resorcylic Acid Derivatives from the Alga-Derived Fungus Penicillium antarcticum KMM 4685

Author

Leshchenko, Elena V., primary, Antonov, Alexandr S., additional, Borkunov, Gleb V., additional, Hauschild, Jessica, additional, Zhuravleva, Olesya I., additional, Khudyakova, Yuliya V., additional, Menshov, Alexander S., additional, Popov, Roman S., additional, Kim, Natalya Yu, additional, Graefen, Markus, additional, Bokemeyer, Carsten, additional, von Amsberg, Gunhild, additional, Yurchenko, Anton N., additional, and Dyshlovoy, Sergey A., additional

Published
2023
Full Text
View/download PDF

6. Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity

Author

Leshchenko, Elena V., primary, Antonov, Alexandr S., additional, Dyshlovoy, Sergey A., additional, Berdyshev, Dmitrii V., additional, Hauschild, Jessica, additional, Zhuravleva, Olesya I., additional, Borkunov, Gleb V., additional, Menshov, Alexander S., additional, Kirichuk, Natalya N., additional, Popov, Roman S., additional, Gerasimenko, Andrey V., additional, Udovenko, Anatoly A., additional, Graefen, Markus, additional, Bokemeyer, Carsten, additional, von Amsberg, Gunhild, additional, and Yurchenko, Anton N., additional

Published
2022
Full Text
View/download PDF

7. Meroantarctines A-C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus KMM 4685 with Potent p-Glycoprotein Inhibitory Activity.

Author

Leshchenko, Elena V., Antonov, Alexandr S., Dyshlovoy, Sergey A., Berdyshev, Dmitrii V., Hauschild, Jessica, Zhuravleva, Olesya I., Borkunov, Gleb V., Menshov, Alexander S., Kirichuk, Natalya N., Popov, Roman S., Gerasimenko, Andrey V., Udovenko, Anatoly A., Graefen, Markus, Bokemeyer, Carsten, von Amsberg, Gunhild, and Yurchenko, Anton N.

Published
2022
Full Text
View/download PDF

8. New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinumZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy

Author

Borkunov, Gleb V., Leshchenko, Elena V., Berdyshev, Dmitrii V., Popov, Roman S., Chingizova, Ekaterina A., Shlyk, Nadezhda P., Gerasimenko, Andrey V., Kirichuk, Natalya N., Khudyakova, Yuliya V., Chausova, Viktoria E., Antonov, Alexandr S., Kalinovsky, Anatoly I., Chingizov, Artur R., Yurchenko, Ekaterina A., Isaeva, Marina P., and Yurchenko, Anton N.

Abstract

Graphical Abstract:

Published
2024
Full Text
View/download PDF

9. Meroantarctines A–C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticumKMM 4685 with Potent p-Glycoprotein Inhibitory Activity

Author

Leshchenko, Elena V., Antonov, Alexandr S., Dyshlovoy, Sergey A., Berdyshev, Dmitrii V., Hauschild, Jessica, Zhuravleva, Olesya I., Borkunov, Gleb V., Menshov, Alexander S., Kirichuk, Natalya N., Popov, Roman S., Gerasimenko, Andrey V., Udovenko, Anatoly A., Graefen, Markus, Bokemeyer, Carsten, von Amsberg, Gunhild, and Yurchenko, Anton N.

Abstract

New meroterpenoids, meroantarctines A–C (1–3), with unique 6/5/6/6, 6/5/6/5/6, and 6/5/6/5 polycyclic systems were isolated from the alga-derived fungus Penicillium antarcticumKMM 4685. Their structures were elucidated by spectroscopic methods, X-ray diffraction, and quantum chemical calculations. A biogenetic pathway for 1–3was proposed. Meroantarctines A–C (1–3) inhibited p-glycoprotein activity and could resensitize drug-resistant cancer cells to docetaxel.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results