Introduction: Food security has become a major global concern, particularly in urban areas where households are struggling to address the issue of basic necessities mainly food that crucially dictates human health. Overcoming these challenges will require effective management mechanisms to inform policy interventions and enhance resilience at both local and global levels. Objectives: This study aimed to explore the coping strategies (CS) pursued by urban households in the Southern Ethiopia. Furthermore, the focus is on how households to cope with food insecurity and how using these strategies varies within households. Methods: A household survey questionnaire was conducted using a cross‐sectional design, combining both qualitative and quantitative methods to collect data. A total of 310 household heads were targeted for the required data acquisition with: The coping strategy index (CSI) to capture how people perceive and cope with food insecurity that threatens human health. Results: The results indicate that households used the top seven CS to address the problem of food insecurity: limiting the size of portions at mealtimes (83.9%), depending on less expensive or seasonal foods (68.1%), reducing adult consumption (66.1%), reducing the amount of food consumed (65.8%), purchasing food on credit (60.3%), renting household assets (54.8%), and migrating household members for wage labor (53.5%). Conclusion: Moreover, the finding shows that the frequency of CS used by urban households in response to food insecurity is rated differently as never, rarely, sometimes, and more than 4 times per week. Therefore, targeted support programs for vulnerable groups should be implemented to ensure they receive adequate food during times of food insecurity wherein the victims' health status is imperatively to be bettered. [ABSTRACT FROM AUTHOR]