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With the phenomenal growth of video and image databases, there is a tremendous need for intelligent systems to automatically understand and examine information, as doing so manually is becoming increasingly difficult. The face is important in social interactions because it conveys information. Detecting a person's identity and feelings Humans do not have a great deal of ability to identify. Machines have different faces. As a result, an automatic face detection system is essential.in face recognition, facial expression recognition, head-pose estimation, and human–computer interaction, and so on Face detection is a computer technology that determines the location and size of a person's face. It also creates a digital image of a human face. Face detection has been a standout topic in the science field This paper provides an in-depth examination of the various techniques investigated for face detection in digital images. Various face challenges and applications. This paper also discusses detection. Detection features are also provided. In addition, we hold special discussions on the practical aspects of developing a robust face detection system, and finally. This paper concludes with several promising research directions for the future.

Optimization and monitoring of bioprocesses requires the measurement of several process parameters and quality attributes. Mass spectrometry (MS)-based techniques such as those coupled to gas chromatography (GCMS) and liquid Chromatography (LCMS) enable the simultaneous measurement of hundreds of metabolites with high sensitivity. When applied to spent media, such metabolome analysis can help determine the sequence of substrate uptake and metabolite secretion, consequently facilitating better design of initial media and feeding strategy. Furthermore, the analysis of metabolite diversity and abundance from spent media will aid the determination of metabolic phases of the culture and the identification of metabolites as surrogate markers for product titer and quality. This review covers the recent advances in metabolomics analysis applied to the development and monitoring of bioprocesses. In this regard, we recommend a stepwise workflow and guidelines that a bioprocesses engineer can adopt to develop and optimize a fermentation process using spent media analysis. Finally, we show examples of how the use of MS can revolutionize the design and monitoring of bioprocesses., (© 2023 Wiley Periodicals LLC.)

Gerbode defects are rare Ventricular Septal Defects (VSD) constituting approximately one percent cases of congenital heart diseases. The genetic predispositions towards the Gerbode Defect (GD) have remained an unexplored area of study till date. We investigated the genotype-phenotype correlation in patients with Gerbode VSD. Molecular genetic study on Sanger sequencing and subsequent data analysis showed that the contributing sequence variations in the NKX2-5 , GATA4 and TBX5 gene lies in one of the highly conserved regions and this region is responsible for encoding a functional protein. The resulting genotype variation may be responsible for causing the diseased phenotype known as GD.