Search

Your search keyword '"Bories, Phuong-Nhi"' showing total 44 results
Start Over Author "Bories, Phuong-Nhi"
44 results on '"Bories, Phuong-Nhi"'

3. An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism

Author

Gonzalez-Menendez, Pedro, primary, Romano, Manuela, additional, Yan, Hongxia, additional, Deshmukh, Ruhi, additional, Papoin, Julien, additional, Oburoglu, Leal, additional, Daumur, Marie, additional, Dumé, Anne-Sophie, additional, Phadke, Ira, additional, Mongellaz, Cédric, additional, Qu, Xiaoli, additional, Bories, Phuong-Nhi, additional, Fontenay, Michaela, additional, An, Xiuli, additional, Dardalhon, Valérie, additional, Sitbon, Marc, additional, Zimmermann, Valérie S., additional, Gallagher, Patrick G., additional, Tardito, Saverio, additional, Blanc, Lionel, additional, Mohandas, Narla, additional, Taylor, Naomi, additional, and Kinet, Sandrina, additional

Published
2021
Full Text
View/download PDF

4. Relations between undernutrition and nosocomial infections in elderly patients

Author

Paillaud, Elena, Herbaud, Stephane, Caillet, Philippe, Lejonc, Jean-Louis, Campillo, Bernard, and Bories, Phuong-Nhi

Subjects
Cross infection -- Risk factors, Nosocomial infections -- Risk factors, Aged -- Care and treatment, Aged -- Health aspects, Malnutrition -- Risk factors, Health, Psychology and mental health, Seniors, Social sciences
Published
2005

6. An IDH1-Vitamin C Crosstalk Drives Human Erythroid Development By Inhibiting Pro-Oxidant Mitochondrial Metabolism

Author

Gonzalez-Menendez, Pedro, primary, Romano, Manuela, additional, Yan, Hongxia, additional, Oburoglu, Leal, additional, Tardito, Saverio, additional, Daumur, Marie, additional, Dume, Anne-Sophie, additional, Phadke, Ira, additional, Qu, Xiaoli, additional, Bories, Phuong-Nhi, additional, Fontenay, Michaela, additional, An, Xiuli, additional, Dardalhon, Valerie, additional, Sitbon, Marc, additional, Zimmermann, Valerie, additional, Gallagher, Patrick G., additional, Blanc, Lionel, additional, Mohandas, Narla, additional, Kinet, Sandrina, additional, and Taylor, Naomi, additional

Published
2020
Full Text
View/download PDF

14. Establishing assay-specific 97.5th percentile upper reference limit for serum D-2-hydroxyglutarate for the management of patients with acute myeloid leukemia

Author

Bories, Phuong-Nhi, primary, Nakib, Samir, additional, Cynober, Luc, additional, Alary, Anne-Sophie, additional, Coude, Marie-Magdelaine, additional, Chevillon, Florian, additional, Tamburini, Jérôme, additional, Birsen, Rudy, additional, Kosmider, Olivier, additional, and Bouscary, Didier, additional

Published
2018
Full Text
View/download PDF

23. Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging

Author

Horcajada, Patricia, primary, Chalati, Tamim, additional, Serre, Christian, additional, Gillet, Brigitte, additional, Sebrie, Catherine, additional, Baati, Tarek, additional, Eubank, Jarrod F., additional, Heurtaux, Daniela, additional, Clayette, Pascal, additional, Kreuz, Christine, additional, Chang, Jong-San, additional, Hwang, Young Kyu, additional, Marsaud, Veronique, additional, Bories, Phuong-Nhi, additional, Cynober, Luc, additional, Gil, Sophie, additional, Férey, Gérard, additional, Couvreur, Patrick, additional, and Gref, Ruxandra, additional

Published
2009
Full Text
View/download PDF

29. Les modifications de la sensibilité aux hormones au cours du vieillissement : conséquences métaboliques et nutritionnelles

Author

de Bandt, Jean-Pascal, primary, Blondé-Cynober, Françoise, additional, Bories, Phuong Nhi, additional, Cassereau, Catherine, additional, Cynober, Luc, additional, Devanlay, Michel, additional, Le Boucher, Jacques, additional, Minet-Quinard, Régine, additional, Pailla, Karine, additional, Vasson, Marie-Paule, additional, and Villié, Françoise, additional

Published
1998
Full Text
View/download PDF

36. Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.

Author

Horcajada, Patricia, Chalati, Tamim, Serre, Christian, Gillet, Brigitte, Sebrie, Catherine, Baati, Tarek, Eubank, Jarrod F., Heurtaux, Daniela, Clayette, Pascal, Kreuz, Christine, Chang, Jong-San, Hwang, Young Kyu, Marsaud, Veronique, Bories, Phuong-Nhi, Cynober, Luc, Gil, Sophie, Férey, Gérard, Couvreur, Patrick, and Gref, Ruxandra

Subjects
DRUG delivery systems, RETROVIRUS diseases, DOXORUBICIN, CANCER, AIDS
Abstract

In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III)-based metal–organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS. In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

37. Interleukin-10 promoter (−1082) polymorphism in association with repeated hospital-acquired infections in elderly patients

Author

Bories, Phuong-Nhi, Laurent, Marie, Liuu, Evelyne, Denjean, Lydie, Popovici, Theodora, and Paillaud, Elena

Abstract

Infections are frequent complications of hospitalization, particularly in the elderly. Pro- and anti-inflammatory cytokines are essential components of the host response to pathogens and polymorphisms in their genes may contribute to inter-individual variations of the inflammatory response. The aim of this study was to investigate whether cytokine polymorphisms, separately or in combination, could be determining factors in the development of repeated nosocomial infections in elderly hospitalized patients. Tumor necrosis factor-α (−308) and (−238), interleukin-6 (−174) and (−6331), interleukin-10 (−1082) and (−592) polymorphisms were genotyped by PCR and hybridization with fluorescent-labeled probes in 245 hospitalized elderly patients (mean age 85.2 years; SD 6) and compared with those in 145 healthy adults. The distribution of genotypes did not differ between elderly patients and control subjects. The presence of the interleukin-10 A592or A1082allele was more frequent individually and after adjustment for multiple comparisons in patients who suffered from several infections (p= 0.012, odds ratio = 5.3; 95 % confidence interval = 1.2–23.1). Our data support a determinant role for interleukin-10 (−1082) polymorphism in the development of nosocomial infections.

Published
2014
Full Text
View/download PDF

38. α.

Author

Boutten, Anne, Dehoux, Monique, Deschenes, Marianne, Rouzeau, Jean-Denis, Bories, Phuong Nhi, and Durand, Geneviève

Published
1992
Full Text
View/download PDF

40. Prevalence of tri- and tetraantennary glycans of humanα1-acid glycoprotein in release of macrophage inhibitor of interleukin-1 activity

Author

Bories, Phuong Nhi, Feger, Jeanne, Benbernou, NaÏma, Rouzeau, Jean-Denis, Agneray, Jean, and Durand, Geneviève

Abstract

Based on the affinity for concanavalin A (Con A), human a1-acid glycoprotein (AGP) can be separated by chromatography on Con A-Sepharose gel into three variants: Con A unreactive AGP, Con A weakly reactive AGP, and Con A strongly reactive AGP. When exposed to native AGP or to its glycan variants, murine peritoneal macrophages released a factor that inhibited the interleukin-1 (IL-1) proliferative activity as measured in terms of the thymocyte comitogenic assay. Con A unreactive AGP, which contains tri- and tetraantennary glycans and no biantennae, proved to be more effective than Con A weakly and Con A strongly reactive variants, which contain one and two diantennary glycans, respectively. The inhibitory effect was not a function of the negative charge related to the sialyl residues and was not mediated by the maanosyl-fucosyl receptor.

Published
1990
Full Text
View/download PDF

41. Influence of liver failure, ascites, and energy expenditure on the response to oral nutrition in alcoholic liver cirrhosis

Author

Campillo, Bernard, >MD, Bories, Phuong Nhi, >PHD, Pornin, Be´atrice, >MD, Devanlay, Michel, and >PHD

Abstract

The influence of liver failure, ascites, and energy expenditure on the response to oral nutrition was assessed in a group of 55 alcoholic cirrhotic patients. Caloric intake, nutritional status, resting energy expenditure (REE), and Child-Pugh score were evaluated before and after 1 mo of oral nutrition. Patients were severely malnourished, 73% had muscular midarm circumference (MMAC) below the 5th percentile of a reference population, 51% had triceps skinfold thickness below the 25th percentile. Eleven patients were in class A of Child, 19 in class B, and 25 in class C. Twenty-six patients were nonascitic, whereas ascites was resolved in 10 ascitic patients by the end of the study and 19 patients had refractory ascites. Liver damage was more pronounced and did not improve during the study in patients with refractory ascites. Caloric intake was ∼40 kcal/kg of body weight and was in the same range in the three groups according to Child classification. Fat mass (FM) increased, respectively, from 17.4% ± 1.7% to 19.5% ± 1.4%, P < 0.01, in Child A patients; from 17.1% ± 1.4% to 19.3% ± 1.4%, P < 0.001, in Child B patients; and from 17.6% ± 1.5% to 18.8% ± 1.5%, P < 0.05, in Child C patients. The increase in FM was comparable in the three groups, whereas MMAC and the creatinine/height ratio did not change significantly. FM was lower and did not increase in patients with refractory ascites. Child C patients were characterized by an increase in the rate of glucose oxidation ( P < 0.02) and a decrease in the rate of lipid oxidation ( P < 0.05). High-density lipoprotein cholesterol and apolipoprotein (Apo) A1 were reliable indices of improvement of liver function in patients with severe liver failure, ApoA1 was also a marker of improvement of metabolic impairment. With respect to the measured REE/predicted REE ratio calculated according to Harris-Benedict equation ( r ), 19 patients were considered hypermetabolic ( r < 1.1), 30 normometabolic (0.9 < r < 1.1), and 6 hypometabolic ( r < 0.9). An increase in FM correlated with r ( P < 0.01) and was more marked in hypermetabolic patients. In contrast to the other two groups, Child-Pugh score and nutritional status remained unchanged in the hypometabolic patients. These results show that severe liver failure did not preclude improvement of nutritional status provided caloric intake was high. In Child C patients, improvement of nutritional status paralleled improvement of liver function and normalization of oxidative metabolism. Refractory ascites had negative effects on changes in nutritional status and liver function. Despite adequate caloric intake to energy requirements, hypometabolism has a poor prognosis regarding both nutritional status and liver function.

Published
1997
Full Text
View/download PDF

42. Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging

Author

Horcajada, Patricia, Chalati, Tamim, Serre, Christian, Gillet, Brigitte, Sebrie, Catherine, Baati, Tarek, Eubank, Jarrod, Heurtaux, Daniela, Clayette, Pascal, Kreuz, Christine, Chang, Jong-San, Hwang, Young Kyu, Marsaud, Veronique, Bories, Phuong-Nhi, Cynober, Luc, Gil, Sophie, Ferey, Gerard, Couvreur, Patrick, Gref, Ruxandra, Horcajada, Patricia, Chalati, Tamim, Serre, Christian, Gillet, Brigitte, Sebrie, Catherine, Baati, Tarek, Eubank, Jarrod, Heurtaux, Daniela, Clayette, Pascal, Kreuz, Christine, Chang, Jong-San, Hwang, Young Kyu, Marsaud, Veronique, Bories, Phuong-Nhi, Cynober, Luc, Gil, Sophie, Ferey, Gerard, Couvreur, Patrick, and Gref, Ruxandra

Abstract

In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III)-based metal–organic frameworks with engineered cores and surfaces, aswell as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS. In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments.

Full Text
View/download PDF

43. Interleukin-10 promoter (-1082) polymorphism in association with repeated hospital-acquired infections in elderly patients.

Author

Bories PN, Laurent M, Liuu E, Denjean L, Popovici T, and Paillaud E

Subjects
Age Factors, Aged, 80 and over, Female, Genetic Predisposition to Disease, Hospitalization, Humans, Male, Polymorphism, Genetic, Promoter Regions, Genetic, Prospective Studies, Community-Acquired Infections genetics, Interleukin-10 genetics
Abstract

Background: Infections are frequent complications of hospitalization, particularly in the elderly. Pro- and anti-inflammatory cytokines are essential components of the host response to pathogens and polymorphisms in their genes may contribute to inter-individual variations of the inflammatory response. The aim of this study was to investigate whether cytokine polymorphisms, separately or in combination, could be determining factors in the development of repeated nosocomial infections in elderly hospitalized patients., Methods: Tumor necrosis factor-α (-308) and (-238), interleukin-6 (-174) and (-6331), interleukin-10 (-1082) and (-592) polymorphisms were genotyped by PCR and hybridization with fluorescent-labeled probes in 245 hospitalized elderly patients (mean age 85.2 years; SD 6) and compared with those in 145 healthy adults., Results: The distribution of genotypes did not differ between elderly patients and control subjects. The presence of the interleukin-10 A(592) or A(1082) allele was more frequent individually and after adjustment for multiple comparisons in patients who suffered from several infections (p = 0.012, odds ratio = 5.3; 95 % confidence interval = 1.2-23.1)., Conclusion: Our data support a determinant role for interleukin-10 (-1082) polymorphism in the development of nosocomial infections.

Published
2014
Full Text
View/download PDF

44. [Prognosis factors of short and long-term survival in elderly hospitalized patients after percutaneous endoscopic gastrostomy].

Author

Paillaud E, Bories PN, Merlier I, Richardet JP, Jeanfaivre V, and Campillo B

Subjects
Aged, Aged, 80 and over, Anorexia therapy, Dementia complications, Female, Humans, Infections complications, Male, Prognosis, Retrospective Studies, Survival Rate, Enteral Nutrition, Gastroscopy, Gastrostomy adverse effects
Abstract

Objective: Percutaneous endoscopic gastrostomy (PEG) is the procedure of choice to achieve long-term enteral nutrition. The risks and benefits of PEG in elderly hospitalized patients have been poorly documented. The objective of this study was to describe the outcome of elderly patients one-year after insertion of a PEG tube., Patients and Methods: Hospital records of 73 patients who underwent PEG for enteral nutrition were reviewed retrospectively. Data on patient age and sex, preexisting medical conditions such as dementia or pressure sores, indication for PEG, concomitant infection, complications of PEG and death were obtained from the hospital charts., Results: The main indication for PEG was anorexia (49%). Before insertion of the gastrostomy tube, 44% of the patients had pressure scores, 30% had concomitant infection, 45% had dementia. PEG complications were observed in 51 patients. The survival rate at 1, 6 and 12 months was 0.68 [95% confidence interval - CI 95%: 0.56-0.78], 0.48 [CI 95%: 0.36-0.59] and 0.37 [CI 95%: 0.26-0.48] respectively. The presence of an infectious disease or of pressure sores at the time of PEG tube insertion were independently associated with mortality. Median survival of patients with these two factors was 32 days [CI 95%: 11-98]., Conclusion: According to these results, the PEG tubes should be inserted with a delay from infectious diseases and before the occurrence of pressure sores.

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results