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1. Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial

Author

Harrison, Stephen A, Abdelmalek, Manal F, Neff, Guy, Gunn, Nadege, Guy, Cynthia D, Alkhouri, Naim, Bashir, Mustafa R, Freilich, Bradley, Kohli, Anita, Khazanchi, Arun, Sheikh, Muhammad Y, Leibowitz, Mark, Rinella, Mary E, Siddiqui, Mohammad S, Kipnes, Mark, Moussa, Sam E, Younes, Ziad H, Bansal, Meena, Baum, Seth J, Borg, Brian, Ruane, Peter J, Thuluvath, Paul J, Gottwald, Mildred, Khan, Mujib, Chen, Charles, Melchor-Khan, Liza, Chang, William, DePaoli, Alex M, Ling, Lei, and Lieu, Hsiao D

Published
2022
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3. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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4. Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis.

Author

Mayo, Marlyn J., Vierling, John M., Bowlus, Christopher L., Levy, Cynthia, Hirschfield, Gideon M., Neff, Guy W., Galambos, Michael R., Gordon, Stuart C., Borg, Brian B., Harrison, Stephen A., Thuluvath, Paul J., Goel, Aparna, Shiffman, Mitchell L., Swain, Mark G., Jones, David E. J., Trivedi, Palak, Kremer, Andreas E., Aspinall, Richard J., Sheridan, David A., and Dörffel, Yvonne

Subjects
CHOLANGITIS, CLINICAL trials, ADVERSE health care events, NON-alcoholic fatty liver disease, BIOMARKERS
Abstract

Summary: Background: Seladelpar is a potent and selective peroxisome proliferator‐activated receptor‐δ agonist that targets multiple cell types involved in primary biliary cholangitis (PBC), leading to anti‐cholestatic, anti‐inflammatory and anti‐pruritic effects. Aims: To evaluate the long‐term safety and efficacy of seladelpar in patients with PBC. Methods: In an open‐label, international, long‐term extension study, patients with PBC completing seladelpar lead‐in studies continued treatment. Seladelpar was taken orally once daily at doses of 5 or 10 mg with dose adjustment permitted for safety or tolerability. The primary analysis was for safety and the secondary efficacy analysis examined biochemical markers of cholestasis and liver injury. The study was terminated early due to the unexpected histological findings in a concurrent study for non‐alcoholic steatohepatitis, which were subsequently found to predate treatment. Safety and efficacy data were analysed through 2 years. Results: There were no serious treatment‐related adverse events observed among 106 patients treated with seladelpar for up to 2 years. There were four discontinuations for safety, one possibly related to seladelpar. Among 53 patients who completed 2 years of seladelpar, response rates increased from years 1 to 2 for the composite endpoint (alkaline phosphatase [ALP] <1.67 × ULN, ≥15% decrease in ALP, and total bilirubin ≤ULN) and ALP normalisation from 66% to 79% and from 26% to 42%, respectively. In those with elevated bilirubin at baseline, 43% achieved normalisation at year 2. Conclusions: Seladelpar was safe, and markedly improved biochemical markers of cholestasis and liver injury in patients with PBC. These effects were maintained or improved throughout the second year. Clinicaltrials.gov: NCT03301506; Clinicaltrialsregister.eu: 2017‐003910‐16. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Efficacy and Safety of Sofosbuvir/Velpatasvir plus Ribavirin in Patients with Hepatitis C Virus-Related Decompensated Cirrhosis

Author

Flamm, Steven, primary, Lawitz, Eric, additional, Borg, Brian, additional, Charlton, Michael, additional, Landis, Charles, additional, Reddy, K. Rajender, additional, Shiffman, Mitchell, additional, Alsina, Angel, additional, Chang, Charissa, additional, Ravendhran, Natarajan, additional, Hernandez, Candido, additional, Hézode, Christophe, additional, Scherbakovsky, Stacey, additional, Mercier, Renee-Claude, additional, and Samuel, Didier, additional

Published
2023
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6. The MRI and AST (MAST) score is correlated with noninvasive and histologic markers of fibrosis in patients with advanced fibrosis due to NASH

Author

Noureddin, Mazen, primary, Kowdley, Kris V., additional, Kohli, Anita, additional, Sheikh, Aasim, additional, Neff, Guy, additional, Bhandari, Bal Raj, additional, Gunn, Nadege, additional, Caldwell, Stephen, additional, Goodman, Zachary, additional, Ding, Dora, additional, Ma, Lily, additional, Chuang, Jay, additional, Huss, Ryan, additional, Chung, Chuhan, additional, Myers, Robert, additional, Patel, Keyur, additional, Borg, Brian, additional, Ghalib, Reem, additional, Poulos, John, additional, Younes, Ziad H., additional, Elkhashab, Magdy, additional, Hassanein, Tarek, additional, Iyer, Rajalakshmi, additional, Ruane, Peter, additional, Shiffman, Mitchell, additional, Strasser, Simone, additional, Wong, Vincent Wai-Sun, additional, Loomba, Rohit, additional, and Alkhouri, Naim, additional

Published
2022
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8. Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial

Author

Thompson, Julie, Jones, Natasha, Al‐Khafaji, Ali, Malik, Shahid, Reich, David, Munoz, Santiago, MacNicholas, Ross, Hassanein, Tarek, Teperman, Lewis, Stein, Lance, Duarte‐Rojo, Andrés, Malik, Raza, Adhami, Talal, Asrani, Sumeet, Shah, Nikunj, Gaglio, Paul, Duddempudi, Anupama, Borg, Brian, Jalan, Rajiv, Brown, Robert, Patton, Heather, Satoskar, Rohit, Rossi, Simona, Parikh, Amay, ElSharkawy, Ahmed, Mantry, Parvez, Sher, Linda, Wolf, David, Hart, Marquis, Landis, Charles, Wigg, Alan, Habib, Shahid, McCaughan, Geoffrey, Colquhoun, Steven, Henry, Alyssa, Bedard, Patricia, Landeen, Lee, Millis, Michael, Ashley, Robert, Frank, William, Henry, Andrew, Stange, Jan, and Subramanian, Ram

Published
2018
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9. Su1348: EFFICACY, SAFETY, AND TOLERABILITY OF SELADELPAR IN PATIENTS WITH COMPENSATED LIVER CIRRHOSIS DUE TO PRIMARY BILIARY CHOLANGITIS (PBC); A POOLED ANALYSIS OF PHASE 2 AND PHASE 3 STUDIES

Author

Gordon, Stuart C., primary, Trivedi, Palak, additional, Bowlus, Christopher L., additional, Galambos, Michael, additional, Goel, Aparna, additional, Gulamhusein, Aliya, additional, Levy, Cynthia, additional, Neff, Guy, additional, Stanca, Carmen M., additional, Thorburn, Douglas, additional, Bacon, Bruce R., additional, Borg, Brian B., additional, Doerffel, Yvonne, additional, Forman, Lisa, additional, Freilich, Bradley, additional, Gheorghe, Liliana, additional, Gonzalez-Huezo, Maria Sarai, additional, Harrison, Stephen A., additional, Huang, Jonathan C., additional, Jeong, Sook-Hayng, additional, Kim, Seung-Up, additional, Lake, John, additional, Odin, Joseph, additional, Tak, Won Young, additional, Tobias, Hillel, additional, Vierling, John M., additional, Yang, Ke, additional, Steinberg, Alexandra, additional, Choi, Yun-Jung, additional, Mcwherter, Charles A., additional, and Mayo, Marlyn J., additional

Published
2022
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11. Impact of Pruritus on Quality of Life and Current Treatment Patterns in Patients with Primary Biliary Cholangitis.

Author

Mayo, Marlyn J., Carey, Elizabeth, Smith, Helen T., Mospan, Andrea R., McLaughlin, Megan, Thompson, April, Morris, Heather L., Sandefur, Robert, Kim, W. Ray, Bowlus, Christopher, the TARGET-PBC Investigators, Ankoma-Sey, Victor, Bernstein, David, Borg, Brian, Brown, Robert, Clark, Virginia, Darling, Jama, Dranoff, Jonathan, Elbeshbeshy, Hany, and Forman, Lisa

Subjects
ITCHING, QUALITY of life, CHOLANGITIS, FATIGUE (Physiology), KRUSKAL-Wallis Test, MEDICAL records
Abstract

Background and Aims : Patients with primary biliary cholangitis (PBC) often suffer with pruritus. We describe the impact of pruritus on quality of life and how it is managed in a real-world cohort. Methods : TARGET-PBC is a longitudinal observational cohort of patients with PBC across the USA. Data include information from medical records for three years prior to the date of consent up to 5 years of follow-up. Enrolled patients were asked to complete patient-reported outcome surveys: PBC-40, 5-D itch, and the PROMIS fatigue survey. Kruskal–Wallis tests were used to compare differences in symptoms between groups. Results : A total of 211 patients with completed PRO surveys were included in the current study. PRO respondents were compared with non-respondents in the TARGET-PBC population and were broadly similar. Pruritus was reported in 170 patients (81%), with those reporting clinically significant pruritus (30%) scoring worse across each domain of the PBC-40 and 5-D itch, more frequently having cirrhosis, and having significantly greater levels of fatigue. Patients reporting clinically significant pruritus were more likely to receive treatment, but 33% had never received treatment (no itch = 43.9%, mild itch = 38.3%). Conclusions : The prevalence of pruritus was high in this population, and those reporting clinically significant pruritus had a higher likelihood of having advanced disease and worse quality of life. However, this study found that pruritus in PBC is under-treated. This may be due in part to ineffectiveness of current treatments, poor tolerance, or the lack of FDA-approved medications for pruritus. [ABSTRACT FROM AUTHOR]

Published
2023
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16. A functional SNP of interferon-[gamma], gene is important for interferon-[alpha]-induced and spontaneous recovery from hepatitis C virus infection

Author

Huang, Ying, Yang, Huiying, Borg, Brian B., Su, Xiaowen, Rhodes, Shannon L., Yang, Kai, Tong, Xiaomei, Tang, George, Howell, Charles D., Rosen, Hugo R., Thio, Chloe L., Thomas, David L., Alter, Harvey J., Sapp, Ronda K., and Liang, T. Jake

Subjects
Hepatitis C virus -- Drug therapy, Hepatitis C virus -- Research, Hepatitis C virus -- Genetic aspects, Genetic polymorphisms -- Research, Cytokines -- Genetic aspects, Cytokines -- Research, Science and technology
Abstract

Cytokine polymorphisms are associated with disease outcome and interferon (IFN) treatment response in hepatitis C virus (HCV) infection. We genotyped eight SNPs spanning the entire IFN-[gamma] gene in two cohorts and assessed the association between those polymorphisms and treatment response or spontaneous viral clearance. The first cohort was composed of 284 chronically HCV-infected patients who had received IFN-[alpha]-based therapy and the second was 251 i.v. drug users who had either spontaneously cleared HCV or become chronically infected. A SNP variant located in the proximal IFN-[gamma], promoter region next to the binding motif of heat shock transcription factor (HSF), -764G, was significantly associated with sustained virological response [P = 0.04, odds ratio (OR) = 3.51 (confidence interval 1.0-12.5)]. The association was independently significant in multiple logistic regression (P = 0.04) along with race, viral titer, and genotype. This variant was also significantly associated with spontaneous recovery [P = 0.04, OR = 3.51 (1.0-12.5)] in the second cohort. Functional analyses show that the G allele confers a two- to three-fold higher promoter activity and stronger binding affinity to HSF1 than the C allele. Our study suggests that the IFN-[gamma] promoter SNP -764G/C is functionally important in determining viral clearance and treatment response in HCV-infected patients and may be used as a genetic marker to predict sustained virological response in HCV-infected patients. genetics | human study | cytokine | viral clearance | antiviral treatment

Published
2007

19. Durability of treatment response after 1 year of therapy with seladelpar in patients with primary biliary cholangitis (PBC): final results of an international phase 2 study

Author

Levy, Cynthia, primary, Bowlus, Christopher, additional, Neff, Guy, additional, Swain, Mark G., additional, Michael, Galambos, additional, Mayo, Marlyn J., additional, Goel, Aparna, additional, Trivedi, Palak, additional, Hirschfield, Gideon, additional, Aspinall, Richard, additional, Kremer, Andreas E., additional, Gordon, Stuart C., additional, Borg, Brian, additional, Harrison, Stephen, additional, Jones, David, additional, Thuluvath, Paul, additional, Doerffel, Yvonne, additional, Stanca, Carmen, additional, Sheridan, David, additional, Bacon, Bruce, additional, Berg, Christoph, additional, Thorburn, Douglas, additional, Vierling, John, additional, Shiffman, Mitchell, additional, Odin, Joseph, additional, Hassanein, Tarek, additional, Peyton, Adam, additional, Gulamhusein, Aliya, additional, Landis, Charles, additional, Bernstein, David, additional, Corless, Lynsey, additional, Woerns, Marcus-Alexander, additional, Buggisch, Peter, additional, Bergheanu, Sandrin, additional, Chen, Wendy, additional, Seput-Dingle, Frances, additional, Mao, Lily, additional, Li, Yu, additional, Yang, Ke, additional, Muslimova, Elena, additional, Choi, Yun-Jung, additional, Varga, Monika, additional, Dickinson, Klara, additional, Boudes, Pol, additional, McWherter, Charles, additional, and Steinberg, Alexandra (Sasha), additional

Published
2020
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20. 686 EFFECTS ON PRURITUS AND SLEEP DISTURBANCE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS (PBC) AFTER 1 YEAR OF TREATMENT WITH SELADELPAR, A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA AGONIST: RESULTS OF AN OPEN-LABEL PHASE 2 STUDY

Author

Kremer, Andreas E., primary, Mayo, Marlyn J., additional, Bowlus, Christopher L., additional, Neff, Guy, additional, Swain, Mark G., additional, Galambos, Michael, additional, Goel, Aparna, additional, Trivedi, Palak, additional, Hirschfield, Gideon, additional, Aspinall, Richard, additional, Gordon, Stuart C., additional, Borg, Brian B., additional, Harrison, Stephen, additional, Thuluvath, Paul, additional, Jones, David E., additional, Doerffel, Yvonne, additional, Levy, Cynthia, additional, Stanca, Carmen, additional, Sheridan, David, additional, Vierling, John M., additional, Shiffman, Mitchell L., additional, Odin, Joseph, additional, Bacon, Bruce, additional, Hassanein, Tarek, additional, Thorburn, Douglas, additional, Berg, Christoph, additional, Bernstein, David, additional, Gulamhusein, Aliya, additional, Landis, Charles, additional, Peyton, Adam, additional, Corless, Lynsey, additional, Buggisch, Peter, additional, Wörns, Marcus-Alexander, additional, Bergheanu, Sandrin, additional, Varga, Monika, additional, Li, Yu, additional, Yang, Ke, additional, Dickinson, Klara, additional, Boudes, Pol, additional, McWherter, Charles A., additional, Steinberg, Alexandra, additional, and Choi, Yun-Jung, additional

Published
2020
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21. Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

Author

Chalasani, Naga, primary, Abdelmalek, Manal F., additional, Garcia-Tsao, Guadalupe, additional, Vuppalanchi, Raj, additional, Alkhouri, Naim, additional, Rinella, Mary, additional, Noureddin, Mazen, additional, Pyko, Maxmillan, additional, Shiffman, Mitchell, additional, Sanyal, Arun, additional, Allgood, Adam, additional, Shlevin, Harold, additional, Horton, Rex, additional, Zomer, Eliezer, additional, Irish, William, additional, Goodman, Zachary, additional, Harrison, Stephen A., additional, Traber, Peter G., additional, Abdelmalek, Manal, additional, Balart, Luis, additional, Borg, Brian, additional, Chalasani, Naga, additional, Charlton, Michael, additional, Conjeevaram, Hari, additional, Fuchs, Michael, additional, Ghalib, Reem, additional, Gholam, Pierre, additional, Halegoua-De Marzio, Dina, additional, Harrison, Stephen, additional, Jue, Christopher, additional, Kemmer, Nyingi, additional, Kowdley, Kris, additional, Lai, Michelle, additional, Lawitz, Eric, additional, Loomba, Rohit, additional, Paredes, Angelo, additional, Rockey, Don, additional, Rodriguez, Miguel, additional, Rubin, Raymond, additional, Ryan, Michael, additional, Scanga, Andrew, additional, Sepe, Thomas, additional, Tetri, Brent, additional, Thuluvath, Paul, additional, Torres, Dawn, additional, Vierling, John, additional, Wattacheril, Julia, additional, Weiland, Amanda, additional, and Zogg, Donald, additional

Published
2020
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22. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Author

Younossi, Zobair M, primary, Ratziu, Vlad, additional, Loomba, Rohit, additional, Rinella, Mary, additional, Anstee, Quentin M, additional, Goodman, Zachary, additional, Bedossa, Pierre, additional, Geier, Andreas, additional, Beckebaum, Susanne, additional, Newsome, Philip N, additional, Sheridan, David, additional, Sheikh, Muhammad Y, additional, Trotter, James, additional, Knapple, Whitfield, additional, Lawitz, Eric, additional, Abdelmalek, Manal F, additional, Kowdley, Kris V, additional, Montano-Loza, Aldo J, additional, Boursier, Jerome, additional, Mathurin, Philippe, additional, Bugianesi, Elisabetta, additional, Mazzella, Giuseppe, additional, Olveira, Antonio, additional, Cortez-Pinto, Helena, additional, Graupera, Isabel, additional, Orr, David, additional, Gluud, Lise Lotte, additional, Dufour, Jean-Francois, additional, Shapiro, David, additional, Campagna, Jason, additional, Zaru, Luna, additional, MacConell, Leigh, additional, Shringarpure, Reshma, additional, Harrison, Stephen, additional, Sanyal, Arun J, additional, Abdelmalek, Manal, additional, Abrams, Gary, additional, Aguilar, Humberto, additional, Ahmed, Aijaz, additional, Aigner, Elmar, additional, Aithal, Guruprasad, additional, Ala, Aftab, additional, Alazawi, William, additional, Albillos, Agustin, additional, Allison, Michael, additional, Al-Shamma, Sfa, additional, Andrade, Raul, additional, Andreone, Pietro, additional, Angelico, Mario, additional, Ankoma-Sey, Victor, additional, Anstee, Quentin, additional, Anty, Rodolphe, additional, Araya, Victor, additional, Arenas Ruiz, Juan Ignacio, additional, Arkkila, Perttu, additional, Arora, Marty, additional, Asselah, Tarik, additional, Au, Jennifer, additional, Ayonrinde, Oyekoya, additional, Bailey, Robert James, additional, Balakrishnan, Maya, additional, Bambha, Kiran, additional, Bansal, Meena, additional, Barritt, Sidney, additional, Bate, John, additional, Beato, Jorge, additional, Behari, Jaideep, additional, Bellot, Pablo, additional, Ben Ari, Ziv, additional, Bennett, Michael, additional, Berenguer, Marina, additional, Beretta-Piccoli, Benedetta Terziroli, additional, Berg, Thomas, additional, Bonacini, Maurizio, additional, Bonet, Lucia, additional, Borg, Brian, additional, Bourliere, Marc, additional, Bowman, William, additional, Bradley, David, additional, Brankovic, Marija, additional, Braun, Marius, additional, Bronowicki, Jean-Pierre, additional, Bruno, Savino, additional, Cai, Cindy, additional, Calderon, Amy, additional, Calleja Panero, José Luis, additional, Carey, Elizabeth, additional, Carmiel, Michal, additional, Carrión, Jose Antonio, additional, Cave, Matthew, additional, Chagas, Cristina, additional, Chami, Tawfik, additional, Chang, Alan, additional, Coates, Allan, additional, Cobbold, Jeremy, additional, Costentin, Charlote, additional, Corey, Kathleen, additional, Corless, Lynsey, additional, Crespo, Javier, additional, Cruz Pereira, Oscar, additional, de Ledinghen, Victor, additional, deLemos, Andrew, additional, Diago, Moises, additional, Dong, Mamie, additional, Dufour, Jean-François, additional, Dugalic, Predrag, additional, Dunn, Winston, additional, Elkhashab, Magby, additional, Epstein, Michael, additional, Escudero-Garcia, Maria Desamparados, additional, Etzion, Ohad, additional, Evans, Larry, additional, Falcone, Robert, additional, Fernandez, Conrado, additional, Ferreira, Jose, additional, Fink, Scott, additional, Finnegan, Kevin, additional, Firpi-Morell, Roberto, additional, Floreani, Annarosa, additional, Fontanges, Thierry, additional, Ford, Ryan, additional, Forrest, Ewan, additional, Fowell, Andrew, additional, Fracanzani, Anna Ludovica, additional, Francque, Sven, additional, Freilich, Bradley, additional, Frias, Juan, additional, Fuchs, Michael, additional, Fuentes, Javier, additional, Galambos, Michael, additional, Gallegos, Juan, additional, Geerts, Anja, additional, George, Jacob, additional, Ghali, Maged, additional, Ghalib, Reem, additional, Gholam, Pierre, additional, Gines, Pere, additional, Gitlin, Norman, additional, Goeser, Tobias, additional, Goff, John, additional, Gordon, Stuart, additional, Gordon, Frederic, additional, Goria, Odile, additional, Greer, Shaun, additional, Grigorian, Alla, additional, Gronbaek, Henning, additional, Guillaume, Maeva, additional, Gunaratnam, Naresh, additional, Halegoua-De Marzio, Dina, additional, Hameed, Bilal, additional, Hametner, Stephanie, additional, Hamilton, James, additional, Hartleb, Marek, additional, Hassanein, Tarek, additional, Häussinger, Dieter, additional, Hellstern, Paul, additional, Herring, Robert, additional, Heurich, Eva, additional, Hezode, Christophe, additional, Hinrichsen, Holger, additional, Holland Fischer, Peter, additional, Horsmans, Yves, additional, Huang, Jonathan, additional, Hussaini, Hyder, additional, Jakiche, Antoine, additional, Jeffers, Lennox, additional, Jones, Blake, additional, Jorge, Rosa, additional, Jorquera, Francisco, additional, Joshi, Shoba, additional, Kahraman, Alisan, additional, Kaita, Kelly, additional, Karyotakis, Nicholas, additional, Kayali, Zeid, additional, Kechagias, Stergios, additional, Kepczyk, Thomas, additional, Khalili, Mandana, additional, Khallafi, Hicham, additional, Kluwe, Johannes, additional, Kohli, Anita, additional, Korenblat, Kevin, additional, Kowdley, Kris, additional, Krag, Aleksander, additional, Krause, Richard, additional, Kremer, Andreas, additional, Krok, Karen, additional, Krstic, Miodrag, additional, Kugelmas, Marcelo, additional, Kumar, Sonal, additional, Kuwada, Scott, additional, Labarriere, Damien, additional, Lai, Michelle, additional, Laleman, Wim, additional, Lampertico, Pietro, additional, Lee, Alice, additional, Leroy, Vincent, additional, Lidofsky, Steven, additional, Lim, Tina Huey, additional, Lim, Joseph, additional, Lipkis, Donald, additional, Little, Ester, additional, Lonardo, Amadeo, additional, Long, Michelle, additional, Luketic, Velimir Anthony Christopher, additional, Lurie, Yoav, additional, Macedo, Guilherme, additional, Magalhaes, Joana, additional, Makara, Mihály, additional, Maliakkal, Benedict, additional, Manns, Michael, additional, Manousou, Pinelopi, additional, Mantry, Parvez, additional, Marchesini, Giulio, additional, Marinho, Carla, additional, Marotta, Paul, additional, Marschall, Hanns-Ulrich, additional, Martinez, Linda, additional, Mayo, Marlyn, additional, McCullen, Mark, additional, McLaughlin, William, additional, Merle, Uta, additional, Merriman, Raphael, additional, Modi, Apurva, additional, Molina, Esther, additional, Montano-Loza, Aldo, additional, Monteverde, Carlos, additional, Morales Cardona, Amilcar, additional, Moreea, Sulleman, additional, Moreno, Christophe, additional, Morisco, Filomena, additional, Mubarak, Abdullah, additional, Muellhaupt, Beat, additional, Mukherjee, Sandeep, additional, Müller, Tobias, additional, Nagorni, Aleksandar, additional, Naik, Jahnavi, additional, Neff, Guy, additional, Nevah, Moises, additional, Newsome, Philip, additional, Nguyen-Khac, Eric, additional, Noureddin, Mazen, additional, Oben, Jude, additional, Orlent, Hans, additional, Orr, James, additional, Ortiz-Lasanta, Grisell, additional, Ozenne, Violaine, additional, Pandya, Prashant, additional, Paredes, Angelo, additional, Park, James, additional, Patel, Joykumar, additional, Patel, Keyur, additional, Paul, Sonali, additional, Patton, Heather, additional, Peck-Radosavljevic, Markus, additional, Petta, Salvatore, additional, Pianko, Stephen, additional, Piekarska, Anna, additional, Pimstone, Neville, additional, Pisegna, Joseph, additional, Pockros, Paul, additional, Pol, Stanislas, additional, Porayko, Michael, additional, Poulos, John, additional, Pound, David, additional, Pouzar, Joe, additional, Presa Ramos, Jose, additional, Pyrsopoulos, Nikolaos, additional, Rafiq, Nila, additional, Muller, Kate, additional, Ramji, Alnoor, additional, Ravinuthala, Ravi, additional, Reddy, Chakradhar, additional, Reddy K G, Gautham, additional, Reddy K R, K. Rajender, additional, Regenstein, Frederic, additional, Reindollar, Robert, additional, Reynolds, Justin, additional, Riera, Andres, additional, Rivera Acosta, Jose, additional, Robaeys, Geert, additional, Roberts, Stuart, additional, Rodriguez-Perez, Federico, additional, Romero, Sandor, additional, Romero-Gomez, Manuel, additional, Rubin, Raymond, additional, Rumi, Mariagrazia, additional, Rushbrook, Simon, additional, Rust, Christian, additional, Ryan, Michael, additional, Safadi, Rifaat, additional, Said, Adnan, additional, Salminen, Kimmo, additional, Samuel, Didier, additional, Santoro, John, additional, Sanyal, Arun, additional, Sarkar, Souvik, additional, Schaeffer, Cynthia, additional, Schattenberg, Jörn, additional, Schiefke, Ingolf, additional, Schiff, Eugene, additional, Schmidt, Wolfgang, additional, Schneider, Jeffrey, additional, Schouten, Jeoffrey, additional, Schultz, Michael, additional, Sebastiani, Giada, additional, Semela, David, additional, Sepe, Thomas, additional, Sheikh, Aasim, additional, Sheikh, Muhammad, additional, Sherman, Kenneth, additional, Shibolet, Oren, additional, Shiffman, Mitchell, additional, Siddique, Asma, additional, Sieberhagen, Cyril, additional, Sigal, Samuel, additional, Sikorska, Katarzyna, additional, Simon, Krzysztof, additional, Sinclair, Marie, additional, Skoien, Richard, additional, Solis, Joel, additional, Sood, Siddharth, additional, Souder, Bob, additional, Spivey, James, additional, Stal, Per, additional, Stinton, Laura, additional, Strasser, Simone, additional, Svorcan, Petar, additional, Szabo, Gyongzi, additional, Talal, Andrew, additional, Tam, Edward, additional, Tetri, Brent, additional, Thuluvath, Paul, additional, Tobias, Hillel, additional, Tomasiewicz, Krzysztof, additional, Torres, Dawn, additional, Tran, Albert, additional, Trauner, Michael, additional, Trautwein, Christian, additional, Tsochatzis, Emanuel, additional, Unitt, Esther, additional, Vargas, Victor, additional, Varkonyi, Istvan, additional, Veitsman, Ella, additional, Vespasiani Gentilucci, Umberto, additional, Victor, David, additional, Vierling, John, additional, Vincent, Catherine, additional, Vincze, Aron, additional, von der Ohe, Manfred, additional, Von Roenn, Natasha, additional, Vuppalanchi, Raj, additional, Waters, Michael, additional, Watt, Kymberly, additional, Wattacheril, Julia, additional, Weltman, Martin, additional, Wieland, Amanda, additional, Wiener, Gregory, additional, Williams A, Alonzo, additional, Williams J, Jeffrey, additional, Wilson, Jason, additional, Yataco, Maria, additional, Yoshida, Eric, additional, Younes, Ziad, additional, Yuan, Liyun, additional, Zivony, Adam, additional, Zogg, Donald, additional, Zoller, Heinz, additional, Zoulim, Fabien, additional, Zuckerman, Eli, additional, and Zuin, Massimo, additional

Published
2019
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27. Featured Cover.

Author

Mayo, Marlyn J., Vierling, John M., Bowlus, Christopher L., Levy, Cynthia, Hirschfield, Gideon M., Neff, Guy W., Galambos, Michael R., Gordon, Stuart C., Borg, Brian B., Harrison, Stephen A., Thuluvath, Paul J., Goel, Aparna, Shiffman, Mitchell L., Swain, Mark G., Jones, David E. J., Trivedi, Palak, Kremer, Andreas E., Aspinall, Richard J., Sheridan, David A., and Dörffel, Yvonne

Subjects
CHOLANGITIS, CLINICAL trials, PHARMACOLOGY
Abstract

This document is a featured cover image for the journal Alimentary Pharmacology & Therapeutics. The image is based on a clinical trial extension study on the safety and efficacy of seladelpar in patients with primary biliary cholangitis. The study was conducted by a team of authors and provides two-year results. The document does not provide any specific details or findings from the study, but it serves as a visual representation of the research. [Extracted from the article]

Published
2024
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28. 953 – High Efficacy and Improvement in Cpt Class with Sofosbuvir/Velpatasvir Plus Ribavirin for 12 Weeks in Patients with Cpt C Decompensated Cirrhosis

Author

Flamm, Steven L., primary, Lawitz, Eric, additional, Borg, Brian, additional, Charlton, Michael, additional, Landis, Charles, additional, Reddy, K. Rajender, additional, Shiffman, Mitchell L., additional, Samuel, Didier, additional, Alsina, Angel, additional, Chang, Charissa Y., additional, Ravendhran, Natarajan, additional, Zhang, Gulan, additional, Cheinquer, Nelson, additional, Moon, Scott, additional, Spellman, James, additional, Stamm, Luisa, additional, Gaggar, Anuj, additional, and Hezode, Christophe, additional

Published
2019
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29. Mo1473 – Seladelpar for the Treatment of Primary Biliary Cholangitis: Experience with 26 Cirrhotic Patients

Author

Mayo, Marlyn J., primary, Bowlus, Christopher L., additional, Galambos, Michael, additional, Neff, Guy, additional, Trivedi, Palak, additional, Goel, Aparna, additional, Odin, Joseph, additional, Bacon, Bruce R., additional, Borg, Brian B., additional, Gordon, Stuart C., additional, Gulamhusein, Aliya, additional, Harrison, Stephen, additional, Levy, Cynthia, additional, stanca, carmen, additional, Vierling, John M., additional, Steinberg, Alexandra, additional, Varga, Monika, additional, Nguyen, Jaidyn, additional, Bergheanu, Sandrin, additional, Choi, Yun-Jung, additional, Standen, Mary, additional, and Boudes, Pol, additional

Published
2019
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30. THU-138-High efficacy and improvement in CPT class with sofosbuvir/velpatasvir plus ribavirin for 12 weeks in patients with CPT C decompensated cirrhosis

Author

Flamm, Steven, primary, Lawitz, Eric, additional, Borg, Brian, additional, Charlton, Michael, additional, Landis, Charles, additional, Reddy, Rajender, additional, Shiffman, Mitchell, additional, Samuel, Didier, additional, Alsina, Angel, additional, Chang, Charissa, additional, Ravendhran, Natarajan, additional, Zhang, Gulan, additional, De-Oertel, Shampa, additional, Stamm, Luisa, additional, Gaggar, Anuj, additional, and Hezode, Christophe, additional

Published
2019
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31. GS-02-Efficacy of GKT831 in patients with primary biliary cholangitis and inadequate response to ursodeoxycholic acid: Interim efficacy results of a phase 2 clinical trial

Author

Dalekos, George, primary, Invernizzi, Pietro, additional, Nevens, Frederik, additional, Hans, Van Vlierberghe, additional, Zigmond, Ehud, additional, Andrade, Raul J., additional, Ari, Ziv Ben, additional, Heneghan, Michael, additional, Huang, Jonathan, additional, Harrison, Stephen, additional, Minuk, Gerald, additional, JörnPD Dr., Schattenberg, additional, Moreno, Christophe, additional, Vierling, John, additional, Vincent, Catherine, additional, Bowlus, Christopher, additional, Lurie, Yoav, additional, Muratori, Luigi, additional, Niro, Grazia, additional, Hirschfield, Gideon, additional, Post, Anthony, additional, Zeuzem, Stefan, additional, Welzel, Tania, additional, Ch’ng, Chin Lye, additional, Levy, Cynthia, additional, Miller, Michael, additional, Albillos, Agustin, additional, Collier, Jane D., additional, Corless, Lynsey, additional, Dieterich, Douglas, additional, Kremer, Andreas E, additional, Papatheodoridis, George, additional, Romeo, David, additional, Silveira, Marina, additional, Bernstein, David, additional, Cohen-Naftaly, Michal, additional, Floreani, Annarosa, additional, Borg, Brian, additional, Carey, Elizabeth, additional, Hollywood, Coral, additional, Maliakkal, Benedict, additional, Marzioni, Marco, additional, Rabinovitz, Mordechai, additional, Rupp, Christian, additional, Sheridan, David, additional, Stanca, Carmen, additional, Swain, Mark G, additional, Veitsman, Ella, additional, Spyridon Dourakis, P, additional, and Wiese, Philippe, additional

Published
2019
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32. PS-122-Seladelpar for the treatment of primary biliary cholangitis: Experience with 26 cirrhotic patients

Author

Mayo, Marlyn J., primary, Bowlus, Christopher, additional, Michael, Galambos, additional, Neff, Guy, additional, Trivedi, Palak, additional, Goel, Aparna, additional, Odin, Joseph, additional, Bacon, Bruce, additional, Borg, Brian, additional, Gordon, Stuart C, additional, Gulamhusein, Aliya, additional, Harrison, Stephen, additional, LEVY, Cynthia, additional, Stanca, Carmen, additional, Vierling, John, additional, Steinberg, Alexandra (Sasha), additional, Varga, Monika, additional, Nguyen, Jaidyn, additional, Bergheanu, Sandrin, additional, Choi, Yun-Jung, additional, Standen, Mary, additional, and Boudes, Pol, additional

Published
2019
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33. Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension

Author

Garcia‐Tsao, Guadalupe, primary, Fuchs, Michael, additional, Shiffman, Mitchell, additional, Borg, Brian B., additional, Pyrsopoulos, Nikolaos, additional, Shetty, Kirti, additional, Gallegos‐Orozco, Juan F., additional, Reddy, K. Rajender, additional, Feyssa, Eyob, additional, Chan, Jean L., additional, Yamashita, Mason, additional, Robinson, James M., additional, Spada, Alfred P., additional, Hagerty, David T., additional, and Bosch, Jaime, additional

Published
2018
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34. Emergent realities for social wellbeing : environmental, spatial and social pathways

Author

Borg, Brian

Subjects
Water utilities -- Malta, Malta. Water Services Corporation, Spatial analysis (Statistics), Geographic information systems -- Malta
Abstract

Making sure that water continues to flow irrespective of population growth, increases in tourism numbers and other seasonal demands, requires a large infrastructure, sophisticated technology, and a dedicated organisation behind it. The Water Services Corporation (WSC) in Malta has evolved over the past two decades into a modern corporation adopting innovative technological solutions and sophisticated technology that has helped deliver the best-quality service to customers. One way is by using geographic information system (GIS) based applications. Adopting this “spatial” strategy has enabled the WSC to determine how core business can exploit location data to improve decision-making, reduce risks, and optimise operations. The WSC is, as far as is known, the first large local organisation to adopt GIS to manage, control, and plan internal projects. Over the years the corporation has built up a very comprehensive GIS capacity that includes the geo-located points of all water meters, valves, taps, and pipes that exist on the Islands. Since the WSC is also responsible for Malta’s wastewater, the company also has the same facilities in this sector too, complete with slope angle and elevation data., peer-reviewed

Published
2017

35. Sa1450 - Hepatoprotective Biomarkers, Amphiregulin and Soluble FAS, Increase During ELAD Treatment in Alcoholic Hepatitis Subjects

Author

Lapetoda, Jason, primary, Anderson, Samantha, additional, Landeen, Lee K., additional, Al-Khafaji, Ali, additional, Parikh, Amay, additional, Duarte-Rojo, Andres, additional, Borg, Brian B., additional, McCaughan, Geoff, additional, Stein, Lance, additional, Allison, Michael, additional, Shah, Nikunj, additional, Subramanian, Ram, additional, Malik, Raza, additional, Brown, Robert S., additional, MacNicholas, Ross, additional, Asrani, Sumeet K., additional, Adhami, Talal, additional, Reich, David, additional, Thompson, Julie, additional, Chacko, Kristina, additional, Teperman, Lewis, additional, Hassanein, Tarek I., additional, and Bedard, Patty W., additional

Published
2018
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36. Sa1449 - Inflammation Biomarkers Decrease During ELAD Treatment in Alcoholic Hepatitis Subjects

Author

Landeen, Lee K., primary, Lapetoda, Jason, additional, Bedard, Patty W., additional, Anderson, Samantha, additional, Li, Zheng, additional, Frank, William, additional, Al-Khafaji, Ali, additional, Parikh, Amay, additional, Duarte-Rojo, Andres, additional, Borg, Brian B., additional, McCaughan, Geoffrey W., additional, Stein, Lance, additional, Allison, Michael, additional, and Subramanian, Ram, additional

Published
2018
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37. Interleukin-6 (IL-6) haplotypes and the response to therapy of chronic hepatitis C virus infection

Author

Yee, Leland J., Im, KyungAh, Borg, Brian, Yang, Huiying, and Liang, T. Jake

Subjects
Adult, Male, Genotype, Interleukin-6, Interferon-alpha, Hepacivirus, Hepatitis C, Chronic, Interferon alpha-2, Middle Aged, Polymorphism, Single Nucleotide, Article, Recombinant Proteins, Polyethylene Glycols, Cohort Studies, Gene Expression Regulation, Gene Frequency, Haplotypes, Multivariate Analysis, Humans, Female, Alleles
Abstract

Chronic hepatitis C virus (HCV) infection affects nearly 170 million individuals worldwide. Treatment of HCV with pegylated interferon-alpha-2a is successful in eradicating virus from only 30 to 80% of those treated. Interleukin-6 (IL-6) is an important cytokine involved in the immune response to infectious agents and in vitro studies suggest that host genetic variation, particularly haplotypes, may affect IL-6 expression. We examined the contribution of haplotypes in the IL-6 gene on sustained viral response (SVR) to the therapy for chronic HCV infection. We observed the IL-6 T-T-G-G-G-G-C-A-G-A haplotype to be associated with a lower risk of achieving SVR among Caucasian Americans (CAs) ((relative risk) RR=0.80; 95% CI: 0.66-0.98; P=0.0261). Using a sliding window approach, the rs1800797-(G)-rs1800796-(G)-rs1800795-(G) haplotype was associated with a reduced chance of SVR (RR=0.79; 95% CI: 0.66-0.94; P=0.0081), as was the rs1800796-(G)-rs1800795-(G)-rs2069830-(C) haplotype (RR=0.78; 95% CI: 0.66-0.94; P=0.0065) among CAs. Overall, the rs1800797-(G)-rs1800796-(G)-rs1800795-(G) haplotype was independently associated with a reduced chance of SVR (RR=0.78; 95% CI: 0.62-1.0; P=0.0489) after adjustment for potential confounding factors. Our findings further illustrate the complexity of IL-6 genetic regulation and the potential importance of haplotypes on IL-6 expression. Our findings provide additional support for the potential importance of genetic variation in the IL-6 gene and the response to HCV therapy.

Published
2009

42. Management of Ameboma Presenting as a Large Ulcerated Cecal Mass.

Author

SHAH, NIRAJ JAMES, BASU, PATRICK, FORTUZI, KED, ALOYSIUS, MARK M., SHEHI, ELONA, BORG, BRIAN B., and GUPTA, NITIN K.

Subjects
MEDICAL societies
Abstract

The article presents a case study of a 45-year-old woman presented with diarrhea, abdominal discomfort and significant weight loss. It mentions diagnosis of colonic amebiasis presenting as an ameboma or an inflammatory mass which mimicked a colonic tumor; and also mentions treatment with Nitazoxanide.

Published
2019

43. Fatal Acute Sickle Cell Intrahepatic Cholestasis Despite Exchange Transfusion: A Case Report and Literature Review.

Author

CAPRA, CARTER, WESLEY ALDRED, L., PATNANA, SRIKRISHNA, BORG, BRIAN, and HERRIN, VINCENT

Subjects
CHOLESTASIS, LIVER biopsy, CLINICAL pathology, INTENSIVE care units, OBSTRUCTIVE jaundice
Abstract

The article presents the case of a 19-year old African American with fatal acute sickle cell intrahepatic cholestasis despite exchange transfusion. He was admitted to the intensive care unit for hypovolemic shock and started on veno-venous hemodialysis. He was treated and then sent for liver biopsy.

Published
2018

48. What's Hot in the Red Journal This Month

Author

Lee, Alexander, primary, Iskander, John M, additional, Gupta, Nitin, additional, Borg, Brian B, additional, Zuckerman, Gary, additional, Banerjee, Bhaskar, additional, and Gyawali, C Prakash, additional

Published
2011
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