45 results on '"Boreatti-Hümmer A"'
Search Results
2. Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
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Lesch, K-P, Selch, S, Renner, T J, Jacob, C, Nguyen, T T, Hahn, T, Romanos, M, Walitza, S, Shoichet, S, Dempfle, A, Heine, M, Boreatti-Hümmer, A, Romanos, J, Gross-Lesch, S, Zerlaut, H, Wultsch, T, Heinzel, S, Fassnacht, M, Fallgatter, A, Allolio, B, Schäfer, H, Warnke, A, Reif, A, Ropers, H-H, and Ullmann, R
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- 2011
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3. Diminished prefrontal oxygenation with normal and above-average verbal fluency performance in adult ADHD
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Schecklmann, Martin, Ehlis, Ann-Christine, Plichta, Michael M., Romanos, Jasmin, Heine, Monika, Boreatti-Hümmer, Andrea, Jacob, Christian, and Fallgatter, Andreas J.
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- 2008
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4. A functional dopamine-β-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders
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Hess, C., Reif, A., Strobel, A., Boreatti-Hümmer, A., Heine, M., Lesch, K.-P., and Jacob, C. P.
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- 2009
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5. Increased EEG power density in alpha and theta bands in adult ADHD patients
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Koehler, S., Lauer, P., Schreppel, T., Jacob, C., Heine, M., Boreatti-Hümmer, A., Fallgatter, A. J., and Herrmann, M. J.
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- 2009
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6. COMT × DRD4 Epistasis Impacts Prefrontal Cortex Function Underlying Response Control
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Heinzel, Sebastian, Dresler, Thomas, Baehne, Christina G., Heine, Monika, Boreatti-Hümmer, Andrea, Jacob, Christian P., Renner, Tobias J., Reif, Andreas, Lesch, Klaus-Peter, Fallgatter, Andreas J., and Ehlis, Ann-Christine
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- 2013
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7. Early Attentional Deficits in an Attention-to-Prepulse Paradigm in ADHD Adults
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Conzelmann, Annette, Pauli, Paul, Mucha, Ronald F., Jacob, Christian P., Gerdes, Antje B., Romanos, Jasmin, Bähne, Christina G., Heine, Monika, Boreatti-Hümmer, Andrea, Alpers, Georg W., Fallgatter, Andreas J., Warnke, Andreas, Lesch, Klaus-Peter, and Weyers, Peter
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- 2010
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8. An international multicenter association study of the serotonin transporter gene in persistent ADHD
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Landaas, E. T., Johansson, S., Jacobsen, K. K., Ribasés, M., Bosch, R., Sánchez-Mora, C., Jacob, C. P., Boreatti-Hümmer, A., Kreiker, S., Lesch, K.-P., Kiemeney, L. A., Kooij, J. J. S., Kan, C., Buitelaar, J. K., Faraone, S. V., Halmøy, A., Ramos-Quiroga, J. A., Cormand, B., Reif, A., Franke, B., Mick, E., Knappskog, P. M., and Haavik, J.
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- 2010
- Full Text
- View/download PDF
9. Emotional deficits in adult ADHD patients: an ERP study
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Herrmann, Martin J., Schreppel, Theresa, Biehl, Stefanie C., Jacob, Christian, Heine, Monika, Boreatti-Hümmer, Andrea, Mühlberger, Andreas, and Fallgatter, Andreas J.
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- 2009
10. COMT x DRD4 Epistasis Impacts Prefrontal Cortex Function Underlying Response Control
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Tobias J. Renner, Andrea Boreatti-Hümmer, Sebastian Heinzel, Andreas Reif, Christian Jacob, Monika Heine, Thomas Dresler, Christina G. Baehne, Klaus-Peter Lesch, Ann-Christine Ehlis, Andreas J. Fallgatter, Psychiatrie & Neuropsychologie, Farmacologie en Toxicologie, and RS: MHeNs School for Mental Health and Neuroscience
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Male ,genetics [Catechol O-Methyltransferase] ,Minisatellite Repeats ,Neuropsychological Tests ,Electroencephalography ,genetics [Attention Deficit Disorder with Hyperactivity] ,Vocabulary ,Gene Frequency ,NoGo-anteriorization ,Prefrontal cortex ,Evoked Potentials ,Brain Mapping ,genetics [Receptors, Dopamine D4] ,medicine.diagnostic_test ,attention-deficit ,Cognition ,Middle Aged ,physiology [Decision Making] ,DRD4 protein, human ,genetics [Reaction Time] ,Female ,hyperactivity disorder (ADHD) ,dopamine ,Psychology ,electroencephalography ,medicine.drug ,Cognitive psychology ,Adult ,Genotype ,Cognitive Neuroscience ,Decision Making ,Prefrontal Cortex ,genetics [Polymorphism, Genetic] ,Catechol O-Methyltransferase ,Inhibitory postsynaptic potential ,Young Adult ,Cellular and Molecular Neuroscience ,Dopamine ,mental disorders ,Reaction Time ,medicine ,Humans ,Attention deficit hyperactivity disorder ,ddc:610 ,genetics [Evoked Potentials] ,genetic epistasis ,Analysis of Variance ,Neural correlates of consciousness ,Polymorphism, Genetic ,Catechol-O-methyl transferase ,genetics [Minisatellite Repeats] ,Receptors, Dopamine D4 ,Epistasis, Genetic ,pathology [Attention Deficit Disorder with Hyperactivity] ,medicine.disease ,pathology [Prefrontal Cortex] ,Attention Deficit Disorder with Hyperactivity ,genetics [Epistasis, Genetic] ,Neuroscience - Abstract
The prefrontal cortex plays a major role in cognitive control, but it is unclear how single genes and gene-gene interactions (genetic epistasis) impact neural and behavioral phenotypes. Both dopamine (DA) availability ('inverted U-model') and excitatory versus inhibitory DA receptor stimulation ('dual-state theory') have been linked to important principles of prefrontal processing. Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were analyzed for effects on behavioral and neural correlates of prefrontal response control (NoGo-anteriorization, NGA) using a Go-NoGo task and electroencephalography (114 controls and 181 patients with attention-deficit/hyperactivity disorder). DRD4 and COMT epistatically interacted on the NGA, whereas single genes and diagnosis showed no significant impact. Subjects with presumably relatively increased D4-receptor function (DRD4: no 7R-alleles) displayed an inverted U-relationship between the NGA and increasing COMT-dependent DA levels, whereas subjects with decreased D4-sensitivity (7R) showed a U-relationship. This interaction was supported by 7R-allele dose effects and mirrored by reaction time variability (non-significant after multiple testing correction). Combining previous theories of prefrontal DA functioning, neural stability at intermediate DA levels may be accompanied by the risk of overly decreased neural flexibility if inhibitory DA receptor function is additionally decreased. Our findings might help to disentangle the genetic basis of dopaminergic mechanisms underlying prefrontal (dys)function.
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- 2013
11. Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation
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Monika Heine, Andrea Boreatti-Hümmer, Andreas J. Fallgatter, Paul Pauli, Thomas Dresler, Ann-Christine Ehlis, Christian Jacob, Marcel Romanos, Martin Schecklmann, and Michael M. Plichta
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Adult ,Male ,610 Medizin ,Prefrontal Cortex ,Short-term memory ,Neuropsychological Tests ,Stop signal ,Impulsivity ,Correlation ,Young Adult ,Developmental and Educational Psychology ,medicine ,ADHD, n-back, stop signal, near-infrared spectroscopy, impulsivity ,Humans ,Attention deficit hyperactivity disorder ,Prefrontal cortex ,Psychiatric Status Rating Scales ,n-back ,ddc:610 ,Spectroscopy, Near-Infrared ,Working memory ,Functional Neuroimaging ,medicine.disease ,Oxygen ,Inhibition, Psychological ,Clinical Psychology ,Memory, Short-Term ,Phenotype ,Attention Deficit Disorder with Hyperactivity ,Impulsive Behavior ,Female ,medicine.symptom ,Psychology ,Neuroscience - Abstract
Objective: It is an open question whether working memory (WM) and response inhibition (RI) constitute one integral phenotype in attention deficit hyperactivity disorder (ADHD). Method: The authors investigated 45 adult ADHD patients and 41 controls comparable for age, gender, intelligence, and education during a letter n-back and a stop-signal task, and measured prefrontal oxygenation by means of functional near-infrared spectroscopy. Results: The authors replicated behavioral and cortical activation deficits in patients compared with controls for both tasks and also for performance in both control conditions. In the patient group, 2-back performance was correlated with stop-signal reaction time. This correlation did not seem to be specific for WM and RI as 1-back performance was correlated with go reaction time. No significant correlations of prefrontal oxygenation between WM and RI were found. Conclusion: The authors’ findings do not support the hypothesis of WM and RI representing one integral phenotype of ADHD mediated by the prefrontal cortex.
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- 2012
12. Cross-Disorder Analysis of Bipolar Risk Genes: Further Evidence of DGKH as a Risk Gene for Bipolar Disorder, but also Unipolar Depression and Adult ADHD
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Volker Arolt, Susanne Kreiker, Henriette N. Buttenschøn, Sabine Herterich, Heike Weber, Bernhard T. Baune, Andrea Boreatti-Hümmer, Katharina Domschke, Andreas Reif, Christian Jacob, Jürgen Deckert, Alexandra Gessner, Lena Weissflog, Thuy Trang Nguyen, Silke Gross-Lesch, Juliane Kopf, Sarah Kittel-Schneider, Klaus-Peter Lesch, Julia Volkert, Maria Neuner, and Ole Mors
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Adult ,Male ,Diacylglycerol Kinase ,Bipolar Disorder ,Genome-wide association study ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Risk Factors ,mental disorders ,medicine ,Humans ,SNP ,Genetic Predisposition to Disease ,ANK3 ,Bipolar disorder ,Aged ,Genetic association ,Pharmacology ,Genetics ,Depressive Disorder ,biology ,NPAS3 ,Haplotype ,Genetic Variation ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Haplotypes ,Attention Deficit Disorder with Hyperactivity ,biology.protein ,Female ,Original Article ,Psychology ,Genome-Wide Association Study - Abstract
Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD) suggested novel risk genes. However, only few of them were followed up and further, the specificity of these genes is even more elusive. To address these issues, we genotyped SNPs in ANK3, CACNA1C, CMTM8, DGKH, EGFR, and NPAS3, which were significantly associated with BPD in previous GWAS, in a sample of 380 BPD patients. Replicated SNPs were then followed up in patients suffering from unipolar depression (UPD; n=387) or adult attention-deficit/hyperactivity disorder (aADHD; n=535). While we could not confirm an association of ANK3, CACNA1C, and EGFR with BPD, 10 SNPs in DGKH, CMTM8, and NPAS3 were nominally associated with disease, with two DGKH markers surviving correction for multiple testing. When these were followed up in UPD and aADHD, seven DGKH SNPs were also associated with UPD, while one SNP each in NPAS3 and CMTM8 and four in DGKH were linked to aADHD. Furthermore, a DGKH haplotype consisting of rs994856/rs9525580/rs9525584 GAT was associated with all disorders tested, while the complementary AGC haplotype was protective. The corresponding haploblock spans a 27-kb region covering exons coding for amino acids 65-243, and thus might include functional variants yet to be identified. We demonstrate an association of DGKH with BPD, UPD, and aADHD by applying a two-stage design. These disorders share the feature of mood instability, so that this phenotype might be associated with genetic variation in DGKH.Neuropsychopharmacology advance online publication, 8 June 2011; doi:10.1038/npp.2011.98.
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- 2011
13. Early attentional deficits in an attention-to-prepulse paradigm in ADHD adults
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Christina G. Bähne, Monika Heine, Georg W. Alpers, Antje B. M. Gerdes, Andrea Boreatti-Hümmer, Ronald F. Mucha, Klaus-Peter Lesch, Annette Conzelmann, Andreas J. Fallgatter, Paul Pauli, Jasmin Romanos, Christian Jacob, Peter Weyers, and Andreas Warnke
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Adult ,Male ,Controlled attention ,Reflex, Startle ,Startle response ,medicine.medical_specialty ,Psychometrics ,Audiology ,Moro reflex ,medicine ,Humans ,Prepulse Facilitation ,Attention ,Habituation, Psychophysiologic ,Biological Psychiatry ,Prepulse inhibition ,medicine.diagnostic_test ,Electromyography ,Information processing ,Cognition ,Clinical Psychology ,Psychiatry and Mental health ,Socioeconomic Factors ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Facilitation ,Female ,Psychology ,Cognitive psychology - Abstract
Adults with attention-deficit/hyperactivity disorder (ADHD) were examined for early and late attentional processes as a function of controlled attention. The test paradigm was the attentional modulation of prepulse inhibition (PPI; early controlled attentional processing) and prepulse facilitation (PPF; late controlled attentional processing). In 49 patients and 49 controls, the authors measured acoustic startle responses to 96-dB startle pulses preceded 120, 240 (for PPI), 2,000, and 4,500 (for PPF) ms by a 68-dB prepulse noise. Geometric figures signaled that prepulses were to be ignored or attended to (automatic vs. controlled attention). ADHD patients exhibited deficits in prepulse modulation, but these reflected an interaction of controlled attention and time of information processing. Normal PPI and PPF occurred under all conditions except for controlled attentional modulation of PPI. Attention deficits in ADHD patients may reflect not general derangements in information processing or ability to attend but, rather, selective disturbances of controlled attention during early information processing.
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- 2010
14. Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
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T. Trang Nguyen, Reinhard Ullmann, Hans-Hilger Ropers, M. Fassnacht, Tobias J. Renner, Andreas J. Fallgatter, Andrea Boreatti-Hümmer, Sebastian Heinzel, Christian Jacob, H. Zerlaut, Sarah A. Shoichet, Tim Hahn, Thomas Wultsch, Susanne Walitza, H. Schäfer, Monika Heine, S. Selch, Marcel Romanos, Andreas Reif, Astrid Dempfle, Jasmin Romanos, Bruno Allolio, Silke Gross-Lesch, K.P. Lesch, Andreas Warnke, and University of Zurich
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Male ,Adolescent ,DNA Copy Number Variations ,2804 Cellular and Molecular Neuroscience ,Gene Dosage ,610 Medicine & health ,Biology ,Genetic determinism ,Cohort Studies ,2738 Psychiatry and Mental Health ,Cellular and Molecular Neuroscience ,mental disorders ,Gene duplication ,1312 Molecular Biology ,Image Processing, Computer-Assisted ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Neuropeptide Y ,Copy-number variation ,Child ,Molecular Biology ,Gene ,Family Health ,Genetics ,Comparative Genomic Hybridization ,Brain ,Chromosome Mapping ,10058 Department of Child and Adolescent Psychiatry ,Neuropeptide Y receptor ,medicine.disease ,Magnetic Resonance Imaging ,Pedigree ,Oxygen ,Psychiatry and Mental health ,Phenotype ,Attention Deficit Disorder with Hyperactivity ,Anticipation (genetics) ,Female ,Chromosomes, Human, Pair 7 ,Genome-Wide Association Study ,Comparative genomic hybridization - Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for copy number variations (CNVs) in a cohort of 99 children and adolescents with severe ADHD. Using high-resolution array comparative genomic hybridization (aCGH), a total of 17 potentially syndrome-associated CNVs were identified. The aberrations comprise 4 deletions and 13 duplications with approximate sizes ranging from 110 kb to 3 Mb. Two CNVs occurred de novo and nine were inherited from a parent with ADHD, whereas five are transmitted by an unaffected parent. Candidates include genes expressing acetylcholine-metabolizing butyrylcholinesterase (BCHE), contained in a de novo chromosome 3q26.1 deletion, and a brain-specific pleckstrin homology domain-containing protein (PLEKHB1), with an established function in primary sensory neurons, in two siblings carrying a 11q13.4 duplication inherited from their affected mother. Other genes potentially influencing ADHD-related psychopathology and involved in aberrations inherited from affected parents are the genes for the mitochondrial NADH dehydrogenase 1 α subcomplex assembly factor 2 (NDUFAF2), the brain-specific phosphodiesterase 4D isoform 6 (PDE4D6) and the neuronal glucose transporter 3 (SLC2A3). The gene encoding neuropeptide Y (NPY) was included in a ∼3 Mb duplication on chromosome 7p15.2-15.3, and investigation of additional family members showed a nominally significant association of this 7p15 duplication with increased NPY plasma concentrations (empirical family-based association test, P=0.023). Lower activation of the left ventral striatum and left posterior insula during anticipation of large rewards or losses elicited by functional magnetic resonance imaging links gene dose-dependent increases in NPY to reward and emotion processing in duplication carriers. These findings implicate CNVs of behaviour-related genes in the pathogenesis of ADHD and are consistent with the notion that both frequent and rare variants influence the development of this common multifactorial syndrome.
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- 2010
15. An international multicenter association study of the serotonin transporter gene in persistent ADHD
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Josep Antoni Ramos-Quiroga, Jan Haavik, Andrea Boreatti-Hümmer, Anne Halmøy, Cornelis C. Kan, Susanne Kreiker, Klaus-Peter Lesch, M. Ribasés, Stefan Johansson, Lambertus A. Kiemeney, Per M. Knappskog, Rosa Bosch, Stephen V. Faraone, J.J.S. Kooij, Eric Mick, Cristina Sánchez-Mora, Jan K. Buitelaar, Andreas Reif, Kaya K. Jacobsen, E.T. Landaas, Barbara Franke, Bru Cormand, and Christian Jacob
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Single-nucleotide polymorphism ,Aetiology, screening and detection [ONCOL 5] ,Polymorphism, Single Nucleotide ,Genomic disorders and inherited multi-system disorders [IGMD 3] ,Behavioral Neuroscience ,Young Adult ,Sex Factors ,Reference Values ,Internal medicine ,Germany ,mental disorders ,Genetics ,medicine ,Perception and Action [DCN 1] ,Attention deficit hyperactivity disorder ,Humans ,Genetic Predisposition to Disease ,Allele ,Psychiatry ,Serotonin transporter ,Genetic Association Studies ,Netherlands ,Serotonin Plasma Membrane Transport Proteins ,Depressive Disorder ,Mental Health [NCEBP 9] ,biology ,Norway ,Age Factors ,Odds ratio ,medicine.disease ,Comorbidity ,Anxiety Disorders ,United States ,Neurology ,Attention Deficit Disorder with Hyperactivity ,Spain ,Evaluation of complex medical interventions [NCEBP 2] ,5-HTTLPR ,Case-Control Studies ,biology.protein ,Anxiety ,Female ,medicine.symptom ,Psychology ,Functional Neurogenomics [DCN 2] - Abstract
Contains fulltext : 88135.pdf (Publisher’s version ) (Closed access) Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder affecting children and adults. It has been suggested that gene variants related to serotonin neurotransmission are associated with ADHD. We tested the functional promoter polymorphism 5-HTTLPR and seven single nucleotide polymorphisms in SLC6A4 for association with ADHD in 448 adult ADHD patients and 580 controls from Norway. Replication attempts were performed in a sample of 1454 Caucasian adult ADHD patients and 1302 controls from Germany, Spain, the Netherlands and USA, and a meta-analysis was performed also including a previously published adult ADHD study. We found an association between ADHD and rs140700 [odds ratio (OR ) = 0.67; P = 0.01] and the short (S) allele of the 5-HTTLPR (OR = 1.19; P = 0.06) in the Norwegian sample. Analysis of a possible gender effect suggested that the association might be restricted to females (rs140700: OR = 0.45; P = 0.00084). However, the meta-analysis of 1894 cases and 1878 controls could not confirm the association for rs140700 [OR = 0.85, 95% confidence interval (CI) = 0.67-1.09; P = 0.20]. For 5-HTTLPR, five of six samples showed a slight overrepresentation of the S allele in patients, but meta-analysis refuted a strong effect (OR = 1.10, 95% CI = 1.00-1.21; P = 0.06). Neither marker showed any evidence of differential effects for ADHD subtype, gender or symptoms of depression/anxiety. In conclusion, our results do not support a major role for SLC6A4 common variants in persistent ADHD, although a modest effect of the 5-HTTLPR and a role for rare variants cannot be excluded. 01 juli 2010
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- 2010
16. Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD
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Josep Antoni Ramos-Quiroga, Christian Jacob, Andrea Boreatti-Hümmer, Noèlia Fernàndez-Castillo, Mònica Bayés, C.C. Kan, Miguel Casas, Philip Asherson, Klaus-Peter Lesch, Cristina Sánchez-Mora, Monika Heine, Bru Cormand, Nuria Gómez-Barros, Helene Barone Halleland, Lambertus A. Kiemeney, Jan Haavik, Ole Bernt Fasmer, E.T. Landaas, Marta Ribasés, Martine Hoogman, Andreas Reif, Angelien Heister, Anne Halmøy, Per M. Knappskog, Rosa Bosch, Stephen V. Faraone, Alejandro Arias Vasquez, Jan K. Buitelaar, Barbara Franke, Jasmin Romanos, A. Marije Boonstra, Stefan Johansson, J. J. Sandra Kooij, Clinical Child and Family Studies, Clinical Neuropsychology, LEARN! - Brain, learning and development, and Department of Psychology, Education and Child Studies
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Adult ,Male ,Internationality ,Adolescent ,Neurogenetics ,Single-nucleotide polymorphism ,Aetiology, screening and detection [ONCOL 5] ,Minisatellite Repeats ,behavioral disciplines and activities ,Genomic disorders and inherited multi-system disorders [IGMD 3] ,Young Adult ,Genotype ,mental disorders ,Perception and Action [DCN 1] ,Humans ,Allele ,Child ,Aged ,Retrospective Studies ,Dopamine transporter ,Genetic association ,Pharmacology ,Genetics ,Mental Health [NCEBP 9] ,Dopamine Plasma Membrane Transport Proteins ,biology ,Haplotype ,Age Factors ,Middle Aged ,Psychiatry and Mental health ,Variable number tandem repeat ,Haplotypes ,Evaluation of complex medical interventions [NCEBP 2] ,Attention Deficit Disorder with Hyperactivity ,biology.protein ,Female ,Original Article ,Psychology ,Functional Neurogenomics [DCN 2] - Abstract
Contains fulltext : 89288.pdf (Publisher’s version ) (Closed access) Attention deficit/hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders with a worldwide prevalence around 4-5% in children and 1-4% in adults. Although ADHD is highly heritable and familial risk may contribute most strongly to the persistent form of the disorder, there are few studies on the genetics of ADHD in adults. In this paper, we present the first results of the International Multicentre Persistent ADHD Genetics CollaboraTion (IMpACT) that has been set up with the goal of performing research into the genetics of persistent ADHD. In this study, we carried out a combined analysis as well as a meta-analysis of the association of the SLC6A3/DAT1 gene with persistent ADHD in 1440 patients and 1769 controls from IMpACT and an earlier report. DAT1, encoding the dopamine transporter, is one of the most frequently studied genes in ADHD, though results have been inconsistent. A variable number tandem repeat polymorphism (VNTR) in the 3'-untranslated region (UTR) of the gene and, more recently, a haplotype of this VNTR with another VNTR in intron 8 have been the target of most studies. Although the 10/10 genotype of the 3'-UTR VNTR and the 10-6 haplotype of the two VNTRs are thought to be risk factors for ADHD in children, we found the 9/9 genotype and the 9-6 haplotype associated with persistent ADHD. In conclusion, a differential association of DAT1 with ADHD in children and in adults might help explain the inconsistencies observed in earlier association studies. However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD. 01 februari 2010
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- 2010
17. Emotional deficits in adult ADHD patients: an ERP study
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Andrea Boreatti-Hümmer, Theresa Schreppel, Andreas J. Fallgatter, Andreas Mühlberger, Christian Jacob, Stefanie C. Biehl, Monika Heine, and Martin J. Herrmann
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Context (language use) ,Electroencephalography ,Audiology ,Brain mapping ,Developmental psychology ,Young Adult ,Event-related potential ,mental disorders ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Young adult ,Reactivity (psychology) ,Electrodes ,Evoked Potentials ,Brain Mapping ,medicine.diagnostic_test ,Mood Disorders ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,Mood disorders ,Attention Deficit Disorder with Hyperactivity ,Female ,Psychology ,Photic Stimulation - Abstract
This study examined general deficits in positive stimuli evaluation in adults with Attention Deficit Hyperactivity Disorder (ADHD). We investigated the event-related potentials to positive, negative and neutral pictures in 32 adults with ADHD and 32 control subjects. For this study we measured 21 electrodes placed in accordance with the international 10-20 system and calculated the early posterior negativity (EPN), which physiologically is characterized by more negative values for emotional as compared to neutral stimuli. We found significantly reduced EPN values for the ADHD patients compared to the healthy controls, but only in the positive stimuli condition, without any significant differences in the negative stimuli condition. Our data indicate that ADHD patients show less reactivity to positive visual stimuli which might be relevant in the context of described dysfunctions of the motivational-reward system in ADHD.
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- 2009
18. Abnormal Affective Responsiveness in Attention-Deficit/Hyperactivity Disorder: Subtype Differences
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Andrea Boreatti-Hümmer, Christina G. Baehne, Paul Pauli, Monika Heine, Georg W. Alpers, Annette Conzelmann, Peter Weyers, Jasmin Romanos, Christian Jacob, Antje B. M. Gerdes, Andreas Warnke, Ronald F. Mucha, Klaus-Peter Lesch, and Andreas J. Fallgatter
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Adult ,Male ,Reflex, Startle ,Startle response ,medicine.medical_specialty ,Audiology ,Impulsivity ,Affect (psychology) ,behavioral disciplines and activities ,Developmental psychology ,Arousal ,mental disorders ,Moro reflex ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Affective Symptoms ,Valence (psychology) ,Biological Psychiatry ,Motivation ,medicine.diagnostic_test ,medicine.disease ,Affect ,Attention Deficit Disorder with Hyperactivity ,Reflex ,Female ,medicine.symptom ,Psychology - Abstract
Background Emotional-motivational dysfunctions likely contribute to attention-deficit/hyperactivity disorder (ADHD), especially to hyperactive and impulsive symptoms. This study examined the affective modulation of the startle reflex in a large sample of ADHD patients. The aim was to compare subtypes of ADHD. Methods One hundred ninety-seven unmedicated adult ADHD patients (127 combined type [ADHD-C]; 50 inattentive type [ADHD-I]; 20 hyperactive-impulsive type [ADHD-HI]) and 128 healthy control subjects were examined. The affect-modulated startle response as well as valence and arousal ratings were assessed for pleasant, neutral, and unpleasant picture stimuli. Results Control subjects exhibited startle response attenuation and potentiation by pleasant and unpleasant pictures, respectively. In ADHD-HI, startle response was not attenuated by pleasant and not potentiated by unpleasant stimuli. In ADHD-C, startle response was not attenuated by pleasant pictures, and ADHD-I responded similar to control subjects but startle response was attenuated to a lesser degree by pleasant stimuli. The ADHD-HI group rated all pictures as more positive, and male ADHD-HI rated unpleasant stimuli as less arousing. Conclusions This is the first study to assess the affect-modulated startle response in ADHD. It confirms emotional dysfunctions in these patients; all subtypes showed more or less diminished emotional reactions to pleasant stimuli. The hyperactive-impulsive type was also marked by blunted reactions to unpleasant stimuli. Results suggest that response patterns to emotional cues or reward may help to differentiate ADHD subtypes. Blunted emotional reactivity is especially pronounced in ADHD patients with symptoms of hyperactivity and impulsivity (ADHD-C, ADHD-HI).
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- 2009
19. Neural correlates of performance monitoring in adult patients with attention deficit hyperactivity disorder (ADHD)
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Paul Pauli, Andrea Boreatti-Hümmer, Martin J. Herrmann, Kathrin Mader, Andreas J. Fallgatter, Ann-Christine Ehlis, Theresa Schreppel, Peter Scheuerpflug, Monika Heine, and Christian Jacob
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Neuropsychological Tests ,Audiology ,behavioral disciplines and activities ,Young Adult ,Event-related potential ,mental disorders ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Psychiatry ,Evoked Potentials ,Biological Psychiatry ,Neural correlates of consciousness ,Error processing ,Adult patients ,Age Factors ,Electroencephalography ,medicine.disease ,Scalp eeg ,Psychiatry and Mental health ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Performance monitoring ,Female ,Psychology ,Eriksen flanker task - Abstract
In this study, the neural correlates of error processing in adult patients with attention deficit hyperactivity disorder (ADHD) are to be investigated for the first time. Recent studies in children with ADHD suggested, with some inconsistencies, deficits in error processing. Based on an analogue study with students, we hypothesized that ADHD patients show reduced amplitudes in the event-related potential (ERP) of the Pe (error positivity) but normal amplitudes of the ERN (error-related negativity) after incorrect responses.In this study we investigated 34 adult ADHD patients and 34 healthy controls with a modified version of the Eriksen flanker task while recording the neural activity with 26 scalp EEG electrodes. Patients discontinued all medication at least 3 days prior to investigation. Age was included as a control variable for the statistical analyses.As hypothesized, we found reduced Pe amplitudes, but also reduced ERN values, in ADHD patients. Importantly, theses differences as well as the deficits in behavioural performance were mainly detectable in the younger subsample, but not in the elderly subsample. Our results indicate that adult ADHD patients are characterized by deficits in error processing, which vanish with age.
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- 2009
20. Diminished prefrontal oxygenation with normal and above-average verbal fluency performance in adult ADHD
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Monika Heine, Christian Jacob, Ann-Christine Ehlis, Andrea Boreatti-Hümmer, Jasmin Romanos, Michael M. Plichta, Martin Schecklmann, and Andreas J. Fallgatter
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Adult ,Male ,medicine.medical_specialty ,Brain activity and meditation ,Prefrontal Cortex ,Audiology ,behavioral disciplines and activities ,Developmental psychology ,Oxygen Consumption ,Phonetics ,Task Performance and Analysis ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Verbal fluency test ,Hyperfocus ,Young adult ,Prefrontal cortex ,Biological Psychiatry ,Brain Mapping ,Spectroscopy, Near-Infrared ,Speech Intelligibility ,medicine.disease ,Executive functions ,Semantics ,Functional imaging ,Psychiatry and Mental health ,Attention Deficit Disorder with Hyperactivity ,Female ,Psychology - Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) in adults is associated with deficits in executive functions such as verbal fluency. Functional near-infrared spectroscopy offers the possibility to measure brain activity during verbal fluency in psychiatric patients due to low susceptibility to movements artefacts. Fourteen patients with mainly combined ADHD subtype and 14 healthy controls matched for age, gender, handedness, education level, and intelligence showed equal performance in phonological verbal fluency and higher performance in semantical verbal fluency in comparison to the controls. On the level of brain function indicated by concentration changes of oxygenated and deoxygenated haemoglobin, both groups showed inferior frontal brain activity during both tasks. ADHD patients had a lower magnitude of oxygenation and a significant negative correlation of brain activity with performance, i.e. higher brain activity was associated with lower performance. These results might be interpreted as a lack of disease related deficits, as an economical recruitment of cognitive resources, or - more likely - as an expression of a benefit in the patient group. High verbal competence in our samples could contribute to these findings. One speculative and post hoc explanation aims at the clinically well-known phenomenon of hyperfocusing in patients with ADHD.
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- 2008
21. Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia
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Susanne Kneitz, Sarah Kittel-Schneider, Andrea Boreatti-Hümmer, Ole Mors, Andreas Reif, Christian Jacob, Jürgen Deckert, Henriette N. Buttenschøn, Claus-Jürgen Scholz, Michael Zimmer, Ulrich Walter, and Klaus-Peter Lesch
- Subjects
Bipolar Disorder ,Tetraspanins ,Single-nucleotide polymorphism ,Genome-wide association study ,Biology ,Polymorphism, Single Nucleotide ,Interviews as Topic ,Cellular and Molecular Neuroscience ,Antigens, Neoplasm ,mental disorders ,medicine ,SNP ,Humans ,Multicenter Studies as Topic ,Bipolar disorder ,Allele ,Gene ,Genetics (clinical) ,Alleles ,Genetics ,Membrane Glycoproteins ,Polymorphism, Genetic ,Haplotype ,Membrane Proteins ,medicine.disease ,Psychiatry and Mental health ,Schizophrenia ,Case-Control Studies ,Genome-Wide Association Study - Abstract
Tetraspanins affect protein trafficking and are known to influence a wide variety of physiologic processes. Recently, single nucleotide polymorphisms (SNPs) of the tetraspanin gene TSPAN8 were found among the best ranked markers of genome wide association studies on bipolar disorder (BPD) (rs1705236) and type-2 diabetes, but functional consequences remained largely unknown. In the present study, we examined 13 tagging SNPs covering the TSPAN8 gene, the intronic TSPAN8 SNP rs1705236 as well as two non-synonymous (ns) SNPs in schizophrenia (SCZ) and BPD samples. In our analysis setting, we were not able to replicate the association of rs1705236 with BPD, nor did we find an association with SCZ. In the TSPAN8 upstream transcriptional control region however, we found rs4500567 to be associated with BPD. In contrast, in SCZ the nsSNP rs3763978 was associated with disease. The significance of both associations withstood conservative Bonferroni correction. In an attempt to link the polymorphisms to functional consequences, we performed an allele-specific in silico mapping of transcription factor binding sites around rs4500567 and predicted the tolerance of the Gly73Ala exchange caused by rs3763978. The results argue for a differential promoter activity specific for the variant associated with BPD, but impaired protein functionality in SCZ. This suggests that TSPAN8 contributes to both diseases, yet with different underlying mechanisms: regulatory versus structural. Similar phenomena might also occur in other risk genes for both BPD and SCZ, providing a molecular basis for the genetic overlap of both entities. (c) 2010 Wiley-Liss, Inc.
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- 2010
22. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations
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Rosa Bosch, M. Ribasés, Bru Cormand, Jan K. Buitelaar, Jan Haavik, Josep Antoni Ramos-Quiroga, Mònica Bayés, Andrea Boreatti-Hümmer, Per M. Knappskog, J.J.S. Kooij, Barbara Franke, Susanne Kreiker, Miguel Casas, Cornelis C. Kan, Andreas Reif, Stefan Johansson, K.P. Lesch, Kaya K. Jacobsen, Thegna Mavroconstanti, Anne Halmøy, E.T. Landaas, Lambertus A. Kiemeney, and Christian Jacob
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Adult ,Genetic Markers ,Male ,Population ,Single-nucleotide polymorphism ,Aetiology, screening and detection [ONCOL 5] ,Tryptophan Hydroxylase ,Biology ,Polymorphism, Single Nucleotide ,Genetic analysis ,White People ,Genomic disorders and inherited multi-system disorders [IGMD 3] ,Molecular epidemiology [NCEBP 1] ,Cellular and Molecular Neuroscience ,Meta-Analysis as Topic ,Genetic variation ,medicine ,Perception and Action [DCN 1] ,Humans ,SNP ,Attention deficit hyperactivity disorder ,Genetic Predisposition to Disease ,Allele ,education ,Alleles ,Genetics (clinical) ,Demography ,Genetics ,education.field_of_study ,Mental Health [NCEBP 9] ,TPH2 ,Norway ,Exons ,medicine.disease ,Psychiatry and Mental health ,Haplotypes ,Attention Deficit Disorder with Hyperactivity ,Evaluation of complex medical interventions [NCEBP 2] ,Case-Control Studies ,Female ,Functional Neurogenomics [DCN 2] - Abstract
Contains fulltext : 89467.pdf (Publisher’s version ) (Closed access) The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. Genetic variants in both genes have been implicated in several psychiatric disorders. For attention-deficit/hyperactivity disorder (ADHD) in children, the results are conflicting, and little is known about their role in adult ADHD patients. We therefore first genotype-tagged all common variants within both genes in a Norwegian sample of 451 patients with a diagnosis of adult ADHD and 584 controls. Six of the single nucleotide polymorphisms (SNPs) were subsequently genotyped in three additional independent European Caucasian samples of adult ADHD cases and controls from the International Multicenter persistent ADHD Collaboration (IMpACT). None of the SNPs reached formal study-wide significance in the total meta-analysis sample of 1,636 cases and 1,923 controls, despite having a power of >80% to detect a variant conferring an OR = 1.25 at P = 0.001 level. Only the TPH1 SNP rs17794760 showed nominal significance [OR = 0.84 (0.71-1.00), P = 0.05]. In conclusion, in the single largest ADHD genetic study of TPH1 and TPH2 variants presented to date (n = 3,559 individuals), we did not find consistent evidence for a substantial effect of common genetic variants on persistent ADHD. 01 juli 2010
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- 2010
23. Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations
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Jan Haavik, Miguel Casas, Cristina Sánchez-Mora, Josep Antoni Ramos-Quiroga, Andrea Boreatti-Hümmer, M. Ribasés, Klaus-Peter Lesch, Barbara Franke, Stefan Johansson, J. J. Sandra Kooij, Cornelis C. Kan, Mònica Bayés, Christian Jacob, Andreas Reif, Rosa Bosch, Eric Mick, Stephen V. Faraone, Jan K. Buitelaar, Monika Heine, Ole Bernt Fasmer, Per M. Knappskog, P. Asherson, Bru Cormand, and Rehabilitation medicine
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Adult ,Male ,Candidate gene ,Genotype ,Population ,Models, Neurological ,Single-nucleotide polymorphism ,Bioinformatics ,Polymorphism, Single Nucleotide ,Cellular and Molecular Neuroscience ,Neurodevelopmental disorder ,Methionine ,Sex Factors ,mental disorders ,medicine ,Perception and Action [DCN 1] ,Attention deficit hyperactivity disorder ,Humans ,education ,Genetics (clinical) ,Genetic association ,Retrospective Studies ,education.field_of_study ,Mental Health [NCEBP 9] ,Models, Genetic ,business.industry ,Brain-Derived Neurotrophic Factor ,Mental Disorders ,Valine ,medicine.disease ,Comorbidity ,Europe ,Psychiatry and Mental health ,Genetics, Population ,Mood disorders ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Female ,business - Abstract
Contains fulltext : 87687.pdf (Publisher’s version ) (Closed access) Attention-deficit hyperactivity disorder (ADHD) is a multifactorial, neurodevelopmental disorder that often persists into adolescence and adulthood and is characterized by inattention, hyperactivity and impulsiveness. Before the advent of the first genome-wide association studies in ADHD, genetic research had mainly focused on candidate genes related to the dopaminergic and serotoninergic systems, although several other genes had also been assessed. Pharmacological data, analysis of animal models and association studies suggest that Brain-Derived Neurotrophic Factor (BDNF) is also a strong candidate gene for ADHD. Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein. To deal with the inconsistency raised among different case-control and family-based association studies regarding the p.Val66Met contribution to ADHD, we performed a meta-analysis of published as well as unpublished data from four different centers that are part of the International Multicentre Persistent ADHD CollaboraTion (IMpACT). A total of 1,445 adulthood ADHD patients and 2,247 sex-matched controls were available for the study. No association between the p.Val66Met polymorphism and ADHD was found in any of the four populations or in the pooled sample. The meta-analysis also showed that the overall gene effect for ADHD was not statistically significant when gender or comorbidity with mood disorders were considered. Despite the potential role of BDNF in ADHD, our data do not support the involvement of p.Val66Met in the pathogenesis of this neuropsychiatric disorder.
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- 2010
24. A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders
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C. Hess, Andrea Boreatti-Hümmer, Alexander Strobel, Andreas Reif, Monika Heine, Christian Jacob, and K.P. Lesch
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Male ,medicine.medical_specialty ,media_common.quotation_subject ,Dopamine beta-Hydroxylase ,Impulsivity ,Personality Disorders ,Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,Revised NEO Personality Inventory ,medicine ,Attention deficit hyperactivity disorder ,Personality ,Humans ,Genetic Predisposition to Disease ,Big Five personality traits ,Psychiatry ,Promoter Regions, Genetic ,Biological Psychiatry ,media_common ,Mood Disorders ,Novelty seeking ,Middle Aged ,medicine.disease ,Personality disorders ,Neuroticism ,Psychiatry and Mental health ,Neurology ,Attention Deficit Disorder with Hyperactivity ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Clinical psychology - Abstract
Dopamine-beta-hydroxylase (DbetaH) catalyzes the conversion of dopamine to norepinephrine in central noradrenergic and adrenergic neurons and thus is critically involved in the biosynthesis of catecholamines. There are equivocal findings concerning the question whether or not DssH activity levels are altered in affective disorders or in subtypes of affective disorders. Moreover, information about the role of dopamine beta-hydroxylase (DBH) genotype, which explains a large part of the variance of enzymatic activity, in affective disorders and personality dimensions is limited. To resolve these inconsistencies, association tests were performed using four independent samples, healthy volunteers (N = 387), patients with affective disorders (N = 182), adult attention deficit hyperactivity disorder (ADHD) patients (N = 407), and patients with personality disorders (N = 637). In the latter two samples, the revised NEO personality inventory (NEO-PI-R) was administered. All participants were genotyped for a putatively functional single nucleotide polymorphism (C-1021T, rs1611115). No differences in DBH C-1021T genotype distribution were observed between patients with affective disorders and healthy control subjects. Also when the patient sample was divided into uni- and bipolar patients versus controls, no significant differences emerged. Furthermore, no clear-cut association was detected between the TT genotype and personality disorder clusters while there was a significant association with adult ADHD. However, personality disorder patients carrying the DBH TT genotype exhibited higher neuroticism and novelty seeking scores as compared to individuals with the CC or CT genotype. Analyses on the level of the neuroticism and novelty seeking subscales revealed that the DBH TT genotype was primarily associated with personality features related to impulsiveness and aggressive hostility. Also adult ADHD patients carrying the homozygous TT genotypes displayed by significantly increased neuroticism scores; when both personality disorder and adult ADHD patient were analyzed together, TT carriers also displayed by significantly lower conscientiousness levels. Our results thus do not implicate the DBH C-1021T polymorphism in the pathophysiology of depressive disorders or personality disorders, yet homozygosity at this locus appears to increase the risk towards personality traits related to impulsiveness, aggression and related disease states, namely adult ADHD. These data argue for a dimensional rather than categorical effect of genetic variance in DBH activity; accordingly, the inconsistency of previous findings concerning DbetaH levels in affective disorders might be caused by the underlying association of the TT genotype at DBH-1021 with impulsive personality traits.
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- 2008
25. Increased EEG power density in alpha and theta bands in adult ADHD patients
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Theresa Schreppel, Andrea Boreatti-Hümmer, P. Lauer, Christian Jacob, Andreas J. Fallgatter, Saskia Koehler, Monika Heine, and Martin J. Herrmann
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Adult ,Male ,medicine.medical_specialty ,Neurology ,Time Factors ,Adolescent ,Statistics as Topic ,Alpha (ethology) ,Electroencephalography ,Audiology ,Brain mapping ,Young Adult ,Sex Factors ,medicine ,Attention deficit hyperactivity disorder ,Humans ,Young adult ,Theta Rhythm ,Psychiatry ,Beta (finance) ,Biological Psychiatry ,Power density ,Brain Mapping ,medicine.diagnostic_test ,Brain ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Alpha Rhythm ,Attention Deficit Disorder with Hyperactivity ,Female ,Neurology (clinical) ,Psychology - Abstract
This study examined EEG abnormalities in adults with attention deficit hyperactivity disorder (ADHD). We investigated EEG frequencies in 34 adults with ADHD and 34 control subjects. Two EEG readings were taken over 5 min intervals during an eyes-closed resting period with 21 electrodes placed in accordance with the international 10-20 system. Fourier transformation was performed to obtain absolute power density in delta, theta, alpha and beta frequency bands. The ADHD patients showed a significant increase of absolute power density in alpha and theta bands. No differences were found for beta activity. Our findings indicate that abnormalities in the EEG power spectrum of adults with ADHD are different than those described in children. Reliable discriminators between patients and healthy subjects in adulthood could be alpha and theta power density. Based on our results, we suggest further research involving longitudinal studies in ADHD patients to investigate the changes of EEG abnormalities with age.
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- 2008
26. Results of stage-adapted therapy of osteochondritis dissecans of the knee joint
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Boreatti-Hümmer, Andrea
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Kniegelenk ,Osteochondrosis dissecans ,ddc:610 - Abstract
Die Osteochondrosis dissecans ist eine aseptische Erkrankung des subchondralen Knochens, welche am häufigsten an konvex geformten Gelenkanteilen auftritt und deren Prognose vorwiegend vom Stadium und vom Patientenalter abhängt. Anhand von 80 Patientendaten wurden die Ergebnisse nach stadienabhängiger Therapie der Osteochondrosis dissecans des Kniegelenkes nach einem durchschnittlichen Zeitraum von 7,5 Jahren untersucht. Die Geschlechterverteilung lag bei 1:5 zugunsten der männlichen Personen, das Durchschnittsalter betrug 26,9 Jahr. Die Ergebnisse wurden als Patientenbefindlichkeit über verschiedene Fragebögen und eine klinische Untersuchung ermittelt., Osteochondritis dissecans is an aseptic disease of the subchondral bone. In most cases convex joints are affected and prognosis dependents on the stage and the age of the patient. We investigated datas of 80 persones affected with osteochondritis dissecans of the knee joint after average 7,5 years. The distribution of sex was 1:5, means men:women. The average value of age was 26,9 years. The results of state of health were found with help of questionaires and a clinical exploration.
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- 2008
27. COMT × DRD4 Epistasis Impacts Prefrontal Cortex Function Underlying Response Control
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Heinzel, Sebastian, primary, Dresler, Thomas, additional, Baehne, Christina G., additional, Heine, Monika, additional, Boreatti-Hümmer, Andrea, additional, Jacob, Christian P., additional, Renner, Tobias J., additional, Reif, Andreas, additional, Lesch, Klaus-Peter, additional, Fallgatter, Andreas J., additional, and Ehlis, Ann-Christine, additional
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- 2012
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28. Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation
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Schecklmann, Martin, primary, Ehlis, Ann-Christine, additional, Plichta, Michael M., additional, Dresler, Thomas, additional, Heine, Monika, additional, Boreatti-Hümmer, Andrea, additional, Romanos, Marcel, additional, Jacob, Christian, additional, Pauli, Paul, additional, and Fallgatter, Andreas J., additional
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- 2012
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29. Cross-Disorder Analysis of Bipolar Risk Genes: Further Evidence of DGKH as a Risk Gene for Bipolar Disorder, but also Unipolar Depression and Adult ADHD
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Weber, Heike, primary, Kittel-Schneider, Sarah, additional, Gessner, Alexandra, additional, Domschke, Katharina, additional, Neuner, Maria, additional, Jacob, Christian P, additional, Buttenschon, Henriette N, additional, Boreatti-Hümmer, Andrea, additional, Volkert, Julia, additional, Herterich, Sabine, additional, Baune, Bernhard T, additional, Gross-Lesch, Silke, additional, Kopf, Juliane, additional, Kreiker, Susanne, additional, Nguyen, Thuy Trang, additional, Weissflog, Lena, additional, Arolt, Volker, additional, Mors, Ole, additional, Deckert, Jürgen, additional, Lesch, Klaus-Peter, additional, and Reif, Andreas, additional
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- 2011
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30. Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHD
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Dresler, Thomas, primary, Ehlis, Ann-Christine, additional, Heinzel, Sebastian, additional, Renner, Tobias J, additional, Reif, Andreas, additional, Baehne, Christina G, additional, Heine, Monika, additional, Boreatti-Hümmer, Andrea, additional, Jacob, Christian P, additional, Lesch, Klaus-Peter, additional, and Fallgatter, Andreas J, additional
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- 2010
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31. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations
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Johansson, Stefan, primary, Halmøy, Anne, additional, Mavroconstanti, Thegna, additional, Jacobsen, Kaya K., additional, Landaas, Elisabeth T., additional, Reif, Andreas, additional, Jacob, Christian, additional, Boreatti‐Hümmer, Andrea, additional, Kreiker, Susanne, additional, Lesch, Klaus‐Peter, additional, Kan, Cornelis C., additional, Kooij, J.J. Sandra, additional, Kiemeney, Lambertus A., additional, Buitelaar, Jan K., additional, Franke, Barbara, additional, Ribasés, Marta, additional, Bosch, Rosa, additional, Bayés, Mònica, additional, Casas, Miguel, additional, Ramos‐Quiroga, Josep Antoni, additional, Cormand, Bru, additional, Knappskog, Per, additional, and Haavik, Jan, additional
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- 2010
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32. Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia
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Scholz, Claus‐Jürgen, primary, Jacob, Christian P., additional, Buttenschon, Henriette N., additional, Kittel‐Schneider, Sarah, additional, Boreatti‐Hümmer, Andrea, additional, Zimmer, Michael, additional, Walter, Ulrich, additional, Lesch, Klaus‐Peter, additional, Mors, Ole, additional, Kneitz, Susanne, additional, Deckert, Jürgen, additional, and Reif, Andreas, additional
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- 2010
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33. Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree
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Lesch, K-P, primary, Selch, S, additional, Renner, T J, additional, Jacob, C, additional, Nguyen, T T, additional, Hahn, T, additional, Romanos, M, additional, Walitza, S, additional, Shoichet, S, additional, Dempfle, A, additional, Heine, M, additional, Boreatti-Hümmer, A, additional, Romanos, J, additional, Gross-Lesch, S, additional, Zerlaut, H, additional, Wultsch, T, additional, Heinzel, S, additional, Fassnacht, M, additional, Fallgatter, A, additional, Allolio, B, additional, Schäfer, H, additional, Warnke, A, additional, Reif, A, additional, Ropers, H-H, additional, and Ullmann, R, additional
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- 2010
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34. Neural correlates of performance monitoring in adult patients with attention deficit hyperactivity disorder (ADHD)
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Herrmann, Martin J., primary, Mader, Kathrin, additional, Schreppel, Theresa, additional, Jacob, Christian, additional, Heine, Monika, additional, Boreatti-Hümmer, Andrea, additional, Ehlis, Ann-Christine, additional, Scheuerpflug, Peter, additional, Pauli, Paul, additional, and Fallgatter, Andreas J., additional
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- 2010
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35. Meta‐analysis of brain‐derived neurotrophic factor p.Val66Met in adult ADHD in four European populations
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Sánchez‐Mora, C., primary, Ribasés, M., additional, Ramos‐Quiroga, J.A., additional, Casas, M., additional, Bosch, R., additional, Boreatti‐Hümmer, A., additional, Heine, M., additional, Jacob, C.P., additional, Lesch, K‐P., additional, Fasmer, O.B., additional, Knappskog, P.M., additional, Kooij, J.J. Sandra, additional, Kan, C., additional, Buitelaar, J.K., additional, Mick, E., additional, Asherson, P., additional, Faraone, S.V., additional, Franke, B., additional, Johansson, S., additional, Haavik, J., additional, Reif, A., additional, Bayés, M., additional, and Cormand, B., additional
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- 2010
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36. Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD
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Franke, Barbara, primary, Vasquez, Alejandro Arias, additional, Johansson, Stefan, additional, Hoogman, Martine, additional, Romanos, Jasmin, additional, Boreatti-Hümmer, Andrea, additional, Heine, Monika, additional, Jacob, Christian P, additional, Lesch, Klaus-Peter, additional, Casas, Miguel, additional, Ribasés, Marta, additional, Bosch, Rosa, additional, Sánchez-Mora, Cristina, additional, Gómez-Barros, Núria, additional, Fernàndez-Castillo, Noèlia, additional, Bayés, Mònica, additional, Halmøy, Anne, additional, Halleland, Helene, additional, Landaas, Elisabeth T, additional, Fasmer, Ole B, additional, Knappskog, Per M, additional, Heister, Angelien J G A M, additional, Kiemeney, Lambertus A, additional, Kooij, J J Sandra, additional, Boonstra, A Marije, additional, Kan, Cees C, additional, Asherson, Philip, additional, Faraone, Stephen V, additional, Buitelaar, Jan K, additional, Haavik, Jan, additional, Cormand, Bru, additional, Ramos-Quiroga, Josep Antoni, additional, and Reif, Andreas, additional
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- 2009
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37. Abnormal Affective Responsiveness in Attention-Deficit/Hyperactivity Disorder: Subtype Differences
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Conzelmann, Annette, primary, Mucha, Ronald F., additional, Jacob, Christian P., additional, Weyers, Peter, additional, Romanos, Jasmin, additional, Gerdes, Antje B.M., additional, Baehne, Christina G., additional, Boreatti-Hümmer, Andrea, additional, Heine, Monika, additional, Alpers, Georg W., additional, Warnke, Andreas, additional, Fallgatter, Andreas J., additional, Lesch, Klaus-Peter, additional, and Pauli, Paul, additional
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- 2009
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38. Increased EEG power density in alpha and theta bands in adult ADHD patients
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Koehler, S., primary, Lauer, P., additional, Schreppel, T., additional, Jacob, C., additional, Heine, M., additional, Boreatti-Hümmer, A., additional, Fallgatter, A. J., additional, and Herrmann, M. J., additional
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- 2008
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39. A functional dopamine-β-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders
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Hess, C., primary, Reif, A., additional, Strobel, A., additional, Boreatti-Hümmer, A., additional, Heine, M., additional, Lesch, K.-P., additional, and Jacob, C. P., additional
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- 2008
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40. S.08.03 Nitric oxide synthase promoter polymorphisms and psychiatric disease states
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Reif, A., primary, Jacob, C.P., additional, Herterich, S., additional, Retz, W., additional, Freitag, C.F., additional, Dempfle, A., additional, Heine, M., additional, Boreatti-Hümmer, A., additional, Rösler, M., additional, and Lesch, K.P., additional
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- 2007
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41. S.08.03 Nitric oxide synthase promoter polymorphisms and psychiatric disease states
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Astrid Dempfle, Christian Jacob, Wolfgang Retz, Sabine Herterich, Michael Rösler, Andrea Boreatti-Hümmer, K.P. Lesch, Andreas Reif, Monika Heine, and C.F. Freitag
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Pharmacology ,Psychiatric Disease ,biology ,business.industry ,Nitric oxide synthase ,Psychiatry and Mental health ,Neurology ,biology.protein ,Medicine ,Pharmacology (medical) ,Neurology (clinical) ,business ,Biological Psychiatry - Published
- 2007
42. Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation.
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Schecklmann, Martin, Ehlis, Ann-Christine, Plichta, Michael M., Dresler, Thomas, Heine, Monika, Boreatti-Hümmer, Andrea, Romanos, Marcel, Jacob, Christian, Pauli, Paul, and Fallgatter, Andreas J.
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- 2013
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43. Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD.
- Author
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Franke, Barbara, Vasquez, Alejandro Arias, Johansson, Stefan, Hoogman, Martine, Romanos, Jasmin, Boreatti-Hümmer, Andrea, Heine, Monika, Jacob, Christian P., Lesch, Klaus-Peter, Casas, Miguel, Ribasés, Marta, Bosch, Rosa, Sánchez-Mora, Cristina, Gómez-Barros, Núria, Fernàndez-Castillo, Noèlia, Bayés, Mònica, Halmøy, Anne, Halleland, Helene, Landaas, Elisabeth T., and Fasmer, Ole B.
- Subjects
NEUROPSYCHIATRY ,BIOLOGICAL psychiatry ,ATTENTION-deficit hyperactivity disorder ,BEHAVIOR disorders in children ,META-analysis - Abstract
Attention deficit/hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders with a worldwide prevalence around 4–5% in children and 1–4% in adults. Although ADHD is highly heritable and familial risk may contribute most strongly to the persistent form of the disorder, there are few studies on the genetics of ADHD in adults. In this paper, we present the first results of the International Multicentre Persistent ADHD Genetics CollaboraTion (IMpACT) that has been set up with the goal of performing research into the genetics of persistent ADHD. In this study, we carried out a combined analysis as well as a meta-analysis of the association of the SLC6A3/DAT1 gene with persistent ADHD in 1440 patients and 1769 controls from IMpACT and an earlier report. DAT1, encoding the dopamine transporter, is one of the most frequently studied genes in ADHD, though results have been inconsistent. A variable number tandem repeat polymorphism (VNTR) in the 3′-untranslated region (UTR) of the gene and, more recently, a haplotype of this VNTR with another VNTR in intron 8 have been the target of most studies. Although the 10/10 genotype of the 3′-UTR VNTR and the 10-6 haplotype of the two VNTRs are thought to be risk factors for ADHD in children, we found the 9/9 genotype and the 9-6 haplotype associated with persistent ADHD. In conclusion, a differential association of DAT1 with ADHD in children and in adults might help explain the inconsistencies observed in earlier association studies. However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD. [ABSTRACT FROM AUTHOR]
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- 2010
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44. Adult ADHD patients show reduced implicit attention to positive stimuli: an examination of the early posterior negativity.
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Biehl, S. C., Schreppel, T., Jacob, C., Heine, M., Boreatti-Hümmer, A., Mühlberger, A., Fallgatter, A. J., and Herrmann, M. J.
- Abstract
Introduction and objective: It is yet unclear whether deficits in facial emotion processing in ADHD extend to the processing of positive and negative stimuli that do not directly depict emotions. The early posterior negativity (EPN) provides the possibility to analyse emotional processing at a neurophysiological level. Methods: Thirty-two adult patients with ADHD who were without medication for 3 days before testing and 32 healthy controls matched for age and gender passively viewed 120 pictures (positive, negative, neutral) from the International Affective Picture System (IAPS). EEG was recorded from 21 electrodes placed according to the extended international 10–20 system and the EPN was calculated. Results: We found significantly smaller EPNs in the group with ADHD compared to healthy controls during the presentation of positive stimuli. Discussion: The results point to a deficit in the processing of positive emotional stimuli and are unlikely to be caused by long-term medication or withdrawal. Conclusion: The reduced EPN indicates a lack of implicit selective attention to positive emotional stimuli and might further implicate a deficient reward system in the aetiology of ADHD symptoms. [ABSTRACT FROM AUTHOR]
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- 2010
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45. COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control.
- Author
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Heinzel S, Dresler T, Baehne CG, Heine M, Boreatti-Hümmer A, Jacob CP, Renner TJ, Reif A, Lesch KP, Fallgatter AJ, and Ehlis AC
- Subjects
- Adult, Analysis of Variance, Brain Mapping, Decision Making physiology, Electroencephalography, Evoked Potentials genetics, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Minisatellite Repeats genetics, Neuropsychological Tests, Polymorphism, Genetic genetics, Reaction Time genetics, Vocabulary, Young Adult, Attention Deficit Disorder with Hyperactivity genetics, Attention Deficit Disorder with Hyperactivity pathology, Catechol O-Methyltransferase genetics, Epistasis, Genetic genetics, Prefrontal Cortex pathology, Receptors, Dopamine D4 genetics
- Abstract
The prefrontal cortex plays a major role in cognitive control, but it is unclear how single genes and gene-gene interactions (genetic epistasis) impact neural and behavioral phenotypes. Both dopamine (DA) availability ("inverted U-model") and excitatory versus inhibitory DA receptor stimulation ("dual-state theory") have been linked to important principles of prefrontal processing. Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were analyzed for effects on behavioral and neural correlates of prefrontal response control (NoGo-anteriorization, NGA) using a Go-NoGo task and electroencephalography (114 controls and 181 patients with attention-deficit/hyperactivity disorder). DRD4 and COMT epistatically interacted on the NGA, whereas single genes and diagnosis showed no significant impact. Subjects with presumably relatively increased D4-receptor function (DRD4: no 7R-alleles) displayed an inverted U-relationship between the NGA and increasing COMT-dependent DA levels, whereas subjects with decreased D4-sensitivity (7R) showed a U-relationship. This interaction was supported by 7R-allele dose effects and mirrored by reaction time variability (non-significant after multiple testing correction). Combining previous theories of prefrontal DA functioning, neural stability at intermediate DA levels may be accompanied by the risk of overly decreased neural flexibility if inhibitory DA receptor function is additionally decreased. Our findings might help to disentangle the genetic basis of dopaminergic mechanisms underlying prefrontal (dys)function.
- Published
- 2013
- Full Text
- View/download PDF
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