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12 results on '"Bordessoulles, Mallaury"'

1. Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies

Author

Bonilla-Ramirez, Leonardo, Rios, Alexandra, Quiliano, Miguel, Ramirez-Calderon, Gustavo, Beltrán-Hortelano, Iván, Franetich, Jean François, Corcuera, Luis, Bordessoulles, Mallaury, Vettorazzi, Ariane, López de Cerain, Adela, Aldana, Ignacio, Mazier, Dominique, Pabón, Adriana, and Galiano, Silvia

Published
2018
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2. Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites

Author

Ashraf, Kutub, primary, Tajeri, Shahin, additional, Arnold, Christophe-Sébastien, additional, Amanzougaghene, Nadia, additional, Franetich, Jean-François, additional, Vantaux, Amélie, additional, Soulard, Valérie, additional, Bordessoulles, Mallaury, additional, Cazals, Guillaume, additional, Bousema, Teun, additional, van Gemert, Geert-Jan, additional, Le Grand, Roger, additional, Dereuddre-Bosquet, Nathalie, additional, Barale, Jean-Christophe, additional, Witkowski, Benoit, additional, Snounou, Georges, additional, Duval, Romain, additional, Botté, Cyrille Y, additional, and Mazier, Dominique, additional

Published
2021
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3. Artemisinin-independent inhibitory activity ofArtemisiasp. infusions against differentPlasmodiumstages including relapse-causing hypnozoites

Author

Ashraf, Kutub, primary, Tajeri, Shahin, additional, Arnold, Christophe-Sébastien, additional, Amanzougaghene, Nadia, additional, Franetich, Jean-François, additional, Vantaux, Amélie, additional, Soulard, Valérie, additional, Bordessoulles, Mallaury, additional, Cazals, Guillaume, additional, Bousema, Teun, additional, van Gemert, Geert-Jan, additional, Grand, Roger Le, additional, Dereuddre-Bosquet, Nathalie, additional, Barale, Jean-Christophe, additional, Witkowski, Benoit, additional, Snounou, Georges, additional, Duval, Romain, additional, Botté, Cyrille Y., additional, and Mazier, Dominique, additional

Published
2021
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4. Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites.

Author

Ashraf, Kutub, Tajeri, Shahin, Arnold, Christophe-Sébastien, Amanzougaghene, Nadia, Franetich, Jean-François, Vantaux, Amélie, Soulard, Valérie, Bordessoulles, Mallaury, Cazals, Guillaume, Bousema, Teun, van Gemert, Geert-Jan, Le Grand, Roger, Dereuddre-Bosquet, Nathalie, Barale, Jean-Christophe, Witkowski, Benoit, Snounou, Georges, Duval, Romain, Botté, Cyrille Y., and Mazier, Dominique

Published
2022
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6. A specific PfEMP1 is expressed in P. falciparum sporozoites and plays a role in hepatocyte infection

Author

Zanghì, Gigliola, Vembar, Shruthi S, Baumgarten, Sebastian, Ding, Shuai, Guizetti, Julien, Bryant, Jessica M, Mattei, Denise, Jensen, Anja T R, Rénia, Laurent, Goh, Yun Shan, Sauerwein, Robert, Hermsen, Cornelus C, Franetich, Jean-François, Bordessoulles, Mallaury, Silvie, Olivier, Soulard, Valérie, Scatton, Olivier, Chen, Patty, Mecheri, Salah, Mazier, Dominique, Scherf, Artur, Zanghì, Gigliola, Vembar, Shruthi S, Baumgarten, Sebastian, Ding, Shuai, Guizetti, Julien, Bryant, Jessica M, Mattei, Denise, Jensen, Anja T R, Rénia, Laurent, Goh, Yun Shan, Sauerwein, Robert, Hermsen, Cornelus C, Franetich, Jean-François, Bordessoulles, Mallaury, Silvie, Olivier, Soulard, Valérie, Scatton, Olivier, Chen, Patty, Mecheri, Salah, Mazier, Dominique, and Scherf, Artur

Abstract

Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparum during blood stage infection. Here, we use ChIP sequencing to demonstrate that sporozoites from mosquito salivary glands expand heterochromatin at subtelomeric regions to silence blood-stage-specific genes. Our data also revealed that heterochromatin enrichment is predictive of the transcription status of clonally variant genes members that mediate cytoadhesion in blood stage parasites. A specific member (here called NF54varsporo) of the var gene family remains euchromatic, and the resultant PfEMP1 (NF54_SpzPfEMP1) is expressed at the sporozoite surface. NF54_SpzPfEMP1-specific antibodies efficiently block hepatocyte infection in a strain-specific manner. Furthermore, human volunteers immunized with infective sporozoites developed antibodies against NF54_SpzPfEMP1. Overall, we show that the epigenetic signature of var genes is reset in mosquito stages. Moreover, the identification of a strain-specific sporozoite PfEMP1 is highly relevant for vaccine design based on sporozoites.

Published
2018

7. A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

Author

Zanghì, Gigliola, primary, Vembar, Shruthi S., additional, Baumgarten, Sebastian, additional, Ding, Shuai, additional, Guizetti, Julien, additional, Bryant, Jessica M., additional, Mattei, Denise, additional, Jensen, Anja T.R., additional, Rénia, Laurent, additional, Goh, Yun Shan, additional, Sauerwein, Robert, additional, Hermsen, Cornelus C., additional, Franetich, Jean-François, additional, Bordessoulles, Mallaury, additional, Silvie, Olivier, additional, Soulard, Valérie, additional, Scatton, Olivier, additional, Chen, Patty, additional, Mecheri, Salah, additional, Mazier, Dominique, additional, and Scherf, Artur, additional

Published
2018
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8. Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages ofPlasmodiumrelapsing species

Author

Cubi, Roger, primary, Vembar, Shruthi S., additional, Biton, Anne, additional, Franetich, Jean-Francois, additional, Bordessoulles, Mallaury, additional, Sossau, Daniel, additional, Zanghi, Gigliola, additional, Bosson-Vanga, Henriette, additional, Benard, Magalie, additional, Moreno, Alicia, additional, Dereuddre-Bosquet, Nathalie, additional, Le Grand, Roger, additional, Scherf, Artur, additional, and Mazier, Dominique, additional

Published
2017
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9. Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

Author

Soulard, Valérie, primary, Bosson-Vanga, Henriette, additional, Lorthiois, Audrey, additional, Roucher, Clémentine, additional, Franetich, Jean- François, additional, Zanghi, Gigliola, additional, Bordessoulles, Mallaury, additional, Tefit, Maurel, additional, Thellier, Marc, additional, Morosan, Serban, additional, Le Naour, Gilles, additional, Capron, Frédérique, additional, Suemizu, Hiroshi, additional, Snounou, Georges, additional, Moreno-Sabater, Alicia, additional, and Mazier, Dominique, additional

Published
2015
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10. Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species.

Author

Cubi, Roger, Vembar, Shruthi S., Biton, Anne, Franetich, Jean‐Francois, Bordessoulles, Mallaury, Sossau, Daniel, Zanghi, Gigliola, Bosson‐Vanga, Henriette, Benard, Magalie, Moreno, Alicia, Dereuddre‐Bosquet, Nathalie, Le Grand, Roger, Scherf, Artur, and Mazier, Dominique

Subjects
PLASMODIUM cynomolgi, MICRODISSECTION, RNA analysis, PLASMODIUM vivax, RNA interference
Abstract

Dormant liver stage forms (hypnozoites) of the malaria parasite Plasmodium vivax present major hurdles to control and eradicate infection. Despite major research efforts, the molecular composition of hypnozoites remains ill defined. Here, we applied a combination of state-of-the-art technologies to generate the first transcriptome of hypnozoites. We developed a robust laser dissection microscopy protocol to isolate individual Plasmodium cynomolgi hypnozoites and schizonts from infected monkey hepatocytes and optimized RNA-seq analysis to obtain the first transcriptomes of these stages. Comparative transcriptomic analysis identified 120 transcripts as being differentially expressed in the hypnozoite stage relative to the dividing liver schizont, with 69 and 51 mRNAs being up- or down-regulated, respectively, in the hypnozoites. This lead to the identification of potential markers of commitment to and maintenance of the dormant state of the hypnozoite including three transcriptional regulators of the ApiAP2 family, one of which is unique to P. cynomolgi and P. vivax, and the global translational repressor, eIF2a kinase eIK2, all of which are upregulated in the hypnozoite. Together, this work not only provides a primary experimentally-derived list of molecular markers of hypnozoites but also identifies transcriptional and posttranscriptional regulation of gene expression as potentially being key to establishing and maintaining quiescence. [ABSTRACT FROM AUTHOR]

Published
2017
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11. A Specific PfEMP1 Is Expressed in P. falciparumSporozoites and Plays a Role in Hepatocyte Infection

Author

Zanghì, Gigliola, Vembar, Shruthi S., Baumgarten, Sebastian, Ding, Shuai, Guizetti, Julien, Bryant, Jessica M., Mattei, Denise, Jensen, Anja T.R., Rénia, Laurent, Goh, Yun Shan, Sauerwein, Robert, Hermsen, Cornelus C., Franetich, Jean-François, Bordessoulles, Mallaury, Silvie, Olivier, Soulard, Valérie, Scatton, Olivier, Chen, Patty, Mecheri, Salah, Mazier, Dominique, and Scherf, Artur

Abstract

Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparumduring blood stage infection. Here, we use ChIP sequencing to demonstrate that sporozoites from mosquito salivary glands expand heterochromatin at subtelomeric regions to silence blood-stage-specific genes. Our data also revealed that heterochromatin enrichment is predictive of the transcription status of clonally variant genes members that mediate cytoadhesion in blood stage parasites. A specific member (here called NF54varsporo) of the vargene family remains euchromatic, and the resultant PfEMP1 (NF54_SpzPfEMP1) is expressed at the sporozoite surface. NF54_SpzPfEMP1-specific antibodies efficiently block hepatocyte infection in a strain-specific manner. Furthermore, human volunteers immunized with infective sporozoites developed antibodies against NF54_SpzPfEMP1. Overall, we show that the epigenetic signature of vargenes is reset in mosquito stages. Moreover, the identification of a strain-specific sporozoite PfEMP1 is highly relevant for vaccine design based on sporozoites.

Published
2018
Full Text
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12. Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species

Author

Cubi, Roger, Vembar, Shruthi S., Biton, Anne, Franetich, Jean-Francois, Bordessoulles, Mallaury, Sossau, Daniel, Zhanghi, Gigliola, Bosson-Vanga, Henriette, Benard, Magalie, Moreno, Alicia, Dereuddre-Bosquet, Nathalie, Le Grand, Roger, Scherf, Artur, Mazier, Dominique, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Eberhard-Karls-University, Plate-Forme de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Parasitologie - Mycologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-High-tech Research Infrastructures for Life Sciences (HeRacLeS), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), HAL-UPMC, Gestionnaire, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Plasmodium, liver stage, Gene Expression Profiling, Haplorhini, Laser Capture Microdissection, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Editor's Choice, Liver, Host-Pathogen Interactions, parasitic diseases, Hepatocytes, Animals, quiescence, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Breaking Report, hypnozoite, Plasmodium cynomolgi
Abstract

International audience; Dormant liver stage forms (hypnozoites) of the malaria parasite Plasmodium vivax present major hurdles to control and eradicate infection. Despite major research efforts, the molecular composition of hypnozoites remains ill defined. Here, we applied a combination of state-of-the-art technologies to generate the first transcriptome of hypnozoites. We developed a robust laser dissection microscopy protocol to isolate individual Plasmodium cynomolgi hypnozoites and schizonts from infected monkey hepatocytes and optimized RNA-seq analysis to obtain the first transcriptomes of these stages. Comparative transcriptomic analysis identified 120 transcripts as being differentially expressed in the hypnozoite stage relative to the dividing liver schizont, with 69 and 51 mRNAs being up- or down-regulated, respectively, in the hypnozoites. This lead to the identification of potential markers of commitment to and maintenance of the dormant state of the hypnozoite including three transcriptional regulators of the ApiAP2 family, one of which is unique to P. cynomolgi and P. vivax, and the global translational repressor, eIF2a kinase eIK2, all of which are upregulated in the hypnozoite. Together, this work not only provides a primary experimentally-derived list of molecular markers of hypnozoites but also identifies transcriptional and posttranscriptional regulation of gene expression as potentially being key to establishing and maintaining quiescence.

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