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1. Der Prozess

Author

Bopp, Dominik; https://orcid.org/0009-0006-5615-6831, Kistler, Alexander; https://orcid.org/0009-0004-3745-7298, Lisik, Natalie, Reber, Kristof; https://orcid.org/0009-0007-7648-0433, Bopp, D ( Dominik ), Kistler, A ( Alexander ), Lisik, N ( Natalie ), Reber, K ( Kristof ), Bopp, Dominik; https://orcid.org/0009-0006-5615-6831, Kistler, Alexander; https://orcid.org/0009-0004-3745-7298, Lisik, Natalie, Reber, Kristof; https://orcid.org/0009-0007-7648-0433, Bopp, D ( Dominik ), Kistler, A ( Alexander ), Lisik, N ( Natalie ), and Reber, K ( Kristof )

Published
2024

3. Der Prozess bei Klageänderung

Author

Bopp, Dominik; https://orcid.org/0009-0006-5615-6831, Kistler, Alexander; https://orcid.org/0009-0004-3745-7298, Natalie, Lisik; https://orcid.org/0009-0003-1296-1159, Reber, Kristof; https://orcid.org/0009-0007-7648-0433, Bopp, D ( Dominik ), Kistler, A ( Alexander ), Natalie, L ( Lisik ), Reber, K ( Kristof ), Bopp, Dominik; https://orcid.org/0009-0006-5615-6831, Kistler, Alexander; https://orcid.org/0009-0004-3745-7298, Natalie, Lisik; https://orcid.org/0009-0003-1296-1159, Reber, Kristof; https://orcid.org/0009-0007-7648-0433, Bopp, D ( Dominik ), Kistler, A ( Alexander ), Natalie, L ( Lisik ), and Reber, K ( Kristof )

Abstract

Der Beitrag beleuchtet die prozessuale Behandlung der Klageänderung. Dazu wird das Verfahren bei einer zulässigen und unzulässigen Klageänderung erläutert, wobei unter anderem die Rechtshängigkeit, die Art und Weise der Erledigung, die Streitwertberechnung, die Kostenverlegung sowie das Rechtsmittelverfahren behandelt werden.

Published
2024

9. Commissioning results of the world's first diode-pumped 10Hz PW laser

Author

Spinka, T., primary, Sistrunk, E., additional, Bayramian, A., additional, Armstrong, J. P., additional, Baxamusa, S., additional, Betts, S., additional, Bopp, D. R., additional, Buck, S., additional, Charron, K., additional, Cupal, J., additional, Demaret, R., additional, Deri, R., additional, Di Nicola, J.-M., additional, Erlandson, A., additional, Fulkerson, E. S., additional, Gates, C., additional, Horner, J., additional, Horacek, J., additional, Jarboe, J., additional, Kasl, K., additional, Kim, D., additional, Koh, E., additional, Koubikova, L., additional, Lanning, R., additional, Lusk, J., additional, Maranville, W., additional, Marshall, C., additional, Mason, D., additional, Menapace, J., additional, Miller, P., additional, Mazurek, P., additional, Naylon, A. J., additional, Nissen, J., additional, Novak, J., additional, Peceli, D., additional, Rosso, P., additional, Schaffers, K., additional, Silva, T., additional, Smith, D., additional, Stanley, J., additional, Steele, R., additional, Stolz, C., additional, Suratwala, T., additional, Telford, S., additional, Thoma, J., additional, VanBlarcom, D., additional, Weiss, J., additional, Wegner, P., additional, Rus, B., additional, and Haefner, C., additional

Published
2017
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10. Sex Determination in the Drosophila Germline Is Dictated by the Sexual Identity of the Surrounding Soma

Author

Waterbury, J. A., Horabin, J. I., Bopp, D., and Schedl, P.

Subjects
Gender identity -- Genetic aspects, Sex differentiation -- Genetic aspects, Biological sciences
Abstract

It has been suggested that sexual identity in the germline depends upon the combination of a nonautonomous somatic signaling pathway and an autonomous X chromosome counting system. In the studies reported here, we have examined the role of the sexual differentiation genes transformer (tra) and doublesex (dsx) in regulating the activity of the somatic signaling pathway. We asked whether ectopic somatic expression of the female products of the tra and dsx genes could feminize the germline of XY animals. We find that [Tra.sup.F] is sufficient to feminize XY germ cells, shutting off the expression of male-specific markers and activating the expression of female-specific markers. Feminization of the germline depends upon the constitutively expressed transformer-2 (tra-2) gene, but does not seem to require a functional dsx gene. However, feminization of XY germ cells by [Tra.sup.F] can be blocked by the male form of the Dsx protein ([Dsx.sup.M]). Expression of the female form of dsx, [Dsx.sup.F], in XY animals also induced germline expression of female markers. Taken together with a previous analysis of the effects of mutations in tra, tra-2, and dsx on the feminization of XX germ cells in XX animals, our findings indicate that the somatic signaling pathway is redundant at the level tra and dsx. Finally, our studies call into question the idea that a cell-autonomous X chromosome counting system plays a central role in germline sex determination.

Published
2000

11. Genetic transformation of the housefly Musca domestica with the lepidopteran derived transposon piggyBac

Author

Hediger M, Niessen M, Ernst A. Wimmer, Dübendorfer A, Bopp D, University of Zurich, and Bopp, D

Subjects
Genetic Markers, 1109 Insect Science, Genetic Vectors, Green Fluorescent Proteins, Gene Expression, Moths, 10124 Institute of Molecular Life Sciences, Luminescent Proteins, Transformation, Genetic, 1311 Genetics, Houseflies, Larva, 1312 Molecular Biology, DNA Transposable Elements, 570 Life sciences, biology, Animals, Baculoviridae
Abstract

The piggyBac transposable element was successfully used for stable genetic transformation of the housefly Musca domestica. The construct contains the EGFP marker under the control of Pax-6 binding sites, which can drive eye-specific expression in insect species as distantly related as Drosophila melanogaster and Tribolium castaneum [Berghammer, A.J., Klingler, M. and Wimmer, E.A. (1999) Nature 402: 370-371]. We obtained seven independent integration events among 41 fertile G0 Musca flies. Most of the transformed lines contained two or more chromosomal insertions of the EGFP marker which were stably inherited over more than 15 generations. piggyBac-mediated transposition was verified by identifying the characteristic TTAA duplication at the insertion sites. This first report of stable transmission of a genetic marker in Musca confirms the use of this vector-marker system for effective gene transfer in a broad range of insect species.

Published
2001

12. Merging sex and position

Author

Bopp, D, University of Zurich, and Bopp, D

Subjects
DNA-Binding Proteins, Homeodomain Proteins, Drosophila melanogaster, 1300 General Biochemistry, Genetics and Molecular Biology, 570 Life sciences, biology, Animals, Drosophila Proteins, Insect Proteins, Nuclear Proteins, Sex Determination Processes, 10124 Institute of Molecular Life Sciences, General Biochemistry, Genetics and Molecular Biology, Transcription Factors
Abstract

The choice between male and female development arises from a simple binary decision made in early development. Studies in a few model organisms led to a detailed understanding of the regulatory mechanisms that convey male or female identity at the cellular level. We have learned little, however, of how this information translates into the actual sexual phenotype with regionally dimorphic characters. Where does positional information come from and how does it integrate with the sex-determining pathway? A recent report sheds light onto this enigma and reveals possible intersections between sex-determining and homeotic pathways in Drosophila. Such intersections may also play an important part in evolution, providing a basis for phenotypic diversity among related species. BioEssays 23:304-306, 2001.

Published
2001

14. The genome of the model beetle and pest tribolium castaneum

Author

Richards, S, Gibbs, RA, Weinstock, GM, Brown, SJ, Denell, R, Beeman, RW, Gibbs, R, Bucher, G, Friedrich, M, Grimmelikhuijzen, CJ, Klingler, M, Lorenzen, M, Roth, S, Schröder, R, Tautz, D, Zdobnov, EM, Muzny, D, Attaway, T, Bell, S, Buhay, CJ, Chandrabose, MN, Chavez, D, Clerk-Blankenburg, KP, Cree, A, Dao, M, Davis, C, Chacko, J, Dinh, H, Dugan-Rocha, S, Fowler, G, Garner, TT, Garnes, J, Gnirke, A, Hawes, A, Hernandez, J, Hines, S, Holder, M, Hume, J, Jhangiani, SN, Joshi, V, Khan, ZM, Jackson, L, Kovar, C, Kowis, A, Lee, S, Lewis, LR, Margolis, J, Morgan, M, Nazareth, LV, Nguyen, N, Okwuonu, G, Parker, D, Ruiz, SJ, Santibanez, J, Savard, J, Scherer, SE, Schneider, B, Sodergren, E, Vattahil, S, Villasana, D, White, CS, Wright, R, Park, Y, Lord, J, Oppert, B, Brown, S, Wang, L, Weinstock, G, Liu, Y, Worley, K, Elsik, CG, Reese, JT, Elhaik, E, Landan, G, Graur, D, Arensburger, P, Atkinson, P, Beidler, J, Demuth, JP, Drury, DW, Du, YZ, Fujiwara, H, Maselli, V, Osanai, M, Robertson, HM, Tu, Z, Wang, JJ, Wang, S, Song, H, Zhang, L, Werner, D, Stanke, M, Morgenstern, B, Solovyev, V, Kosarev, P, Brown, G, Chen, HC, Ermolaeva, O, Hlavina, W, Kapustin, Y, Kiryutin, B, Kitts, P, Maglott, D, Pruitt, K, Sapojnikov, V, Souvorov, A, Mackey, AJ, Waterhouse, RM, Wyder, S, Kriventseva, EV, Kadowaki, T, Bork, P, Aranda, M, Bao, R, Beermann, A, Berns, N, Bolognesi, R, Bonneton, F, Bopp, D, Butts, T, Chaumot, A, Denell, RE, Ferrier, DE, Gordon, CM, Jindra, M, Lan, Q, Lattorff, HM, Laudet, V, von Levetsow, C, Liu, Z, Lutz, R, Lynch, JA, da Fonseca, RN, Posnien, N, Reuter, R, Schinko, JB, Schmitt, C, Schoppmeier, M, Shippy, TD, Simonnet, F, Marques-Souza, H, Tomoyasu, Y, Trauner, J, Van der Zee, M, Vervoort, M, Wittkopp, N, Wimmer, EA, Yang, X, Jones, AK, Sattelle, DB, Ebert, PR, Nelson, D, Scott, JG, Muthukrishnan, S, Kramer, KJ, Arakane, Y, Zhu, Q, Hogenkamp, D, Dixit, R, Jiang, H, Zou, Z, Marshall, J, Elpidina, E, Vinokurov, K, Oppert, C, Evans, J, Lu, Z, Zhao, P, Sumathipala, N, Altincicek, B, Vilcinskas, A, Williams, M, Hultmark, D, Hetru, C, Hauser, F, Cazzamali, G, Williamson, M, Li, B, Tanaka, Y, Predel, R, Neupert, S, Schachtner, J, Verleyen, P, Raible, F, Walden, KK, Angeli, S, Forêt, S, Schuetz, S, Maleszka, R, Miller, SC, Grossmann, D, MDC Library, and Zdobnov, Evgeny

Subjects
0106 biological sciences, Repetitive Sequences, Nucleic Acid/genetics, Insecticides, Proteome, Genome, Insect, Cytochrome P-450 Enzyme System/genetics, Genes, Insect, Insect, Receptors, Odorant, 01 natural sciences, Genome, Receptors, G-Protein-Coupled, G-Protein-Coupled Receptors, Genome, Insect/ genetics, Oogenesis, Cytochrome P-450 Enzyme System, RNA interference, Odorant Receptors, Caenorhabditis elegans, Insect Genome, Phylogeny, media_common, Genetics, ddc:616, 0303 health sciences, Base Composition, Neurotransmitter Agents, Tribolium, Multidisciplinary, Neurotransmitter Agents/genetics, Receptors, Odorant/genetics, Vision, Ocular/genetics, Telomere, Insecticides/pharmacology, DNA Transposable Elements/genetics, Proteome/genetics, Genes, Insect/ genetics, Oogenesis/genetics, Taste, RNA Interference, Growth and Development, Drosophila melanogaster, animal structures, Nucleic Acid Repetitive Sequences, Taste/genetics, media_common.quotation_subject, 570 Life Sciences, Biology, 010603 evolutionary biology, 610 Medical Sciences, Medicine, 03 medical and health sciences, Humans, Insect Genes, Ocular Vision, Animals, Tribolium/classification/embryology/ genetics/physiology, Red flour beetle, Gene, Drosophila, Vision, Ocular, 030304 developmental biology, Repetitive Sequences, Nucleic Acid, Growth and Development/genetics, Telomere/genetics, Body Patterning, fungi, biology.organism_classification, Body Patterning/genetics, Cardiovascular and Metabolic Diseases, DNA Transposable Elements, Receptors, G-Protein-Coupled/genetics
Abstract

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

Published
2008

15. Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment

Author

Scott, JG, Warren, WC, Beukeboom, LW, Bopp, D, Clark, AG, Giers, SD, Hediger, M, Jones, A, Kasai, S, Leichter, CA, Li, M, Meisel, RP, Minx, P, Murphy, TD, Nelson, DR, Reid, WR, Rinkevich, FD, Robertson, HM, Sackton, TB, Sattelle, DB, Thibaud-Nissen, F, Tomlinson, C, van de Zande, L, Walden, KK, Wilson, RK, Liu, N, Scott, JG, Warren, WC, Beukeboom, LW, Bopp, D, Clark, AG, Giers, SD, Hediger, M, Jones, A, Kasai, S, Leichter, CA, Li, M, Meisel, RP, Minx, P, Murphy, TD, Nelson, DR, Reid, WR, Rinkevich, FD, Robertson, HM, Sackton, TB, Sattelle, DB, Thibaud-Nissen, F, Tomlinson, C, van de Zande, L, Walden, KK, Wilson, RK, and Liu, N

Abstract

BACKGROUND: Adult house flies, Musca domestica L., are mechanical vectors of more than 100 devastating diseases that have severe consequences for human and animal health. House fly larvae play a vital role as decomposers of animal wastes, and thus live in intimate association with many animal pathogens. RESULTS: We have sequenced and analyzed the genome of the house fly using DNA from female flies. The sequenced genome is 691 Mb. Compared with Drosophila melanogaster, the genome contains a rich resource of shared and novel protein coding genes, a significantly higher amount of repetitive elements, and substantial increases in copy number and diversity of both the recognition and effector components of the immune system, consistent with life in a pathogen-rich environment. There are 146 P450 genes, plus 11 pseudogenes, in M. domestica, representing a significant increase relative to D. melanogaster and suggesting the presence of enhanced detoxification in house flies. Relative to D. melanogaster, M. domestica has also evolved an expanded repertoire of chemoreceptors and odorant binding proteins, many associated with gustation. CONCLUSIONS: This represents the first genome sequence of an insect that lives in intimate association with abundant animal pathogens. The house fly genome provides a rich resource for enabling work on innovative methods of insect control, for understanding the mechanisms of insecticide resistance, genetic adaptation to high pathogen loads, and for exploring the basic biology of this important pest. The genome of this species will also serve as a close out-group to Drosophila in comparative genomic studies.

Published
2014

16. Sex determination in insects: variations on a common theme

Author

Bopp, D, Saccone, G, Beye, M, Bopp, D, Saccone, G, and Beye, M

Abstract

Recent studies in a representative selection of holometabolous insects suggest that, despite diversity at the instructive level, the signal-relaying part of the sex-determining pathway is remarkably well conserved. In principle, it is composed of the transformer gene (tra) , which acts as a common binary switch that transduces the selected sexual fate, female when ON, male when OFF, to the downstream effector doublesex (dsx) that controls overt sexual differentiation. An interesting recurrent feature is that tra is switched ON in the early zygote by maternally provisioned tra activity. Different male-determining signals evolved, which prevent maternal activation of zygotic tra to allow for male development. In some species, where lack of maternal activation leaves tra in the OFF state, novel female-determining signals were deployedto activate zygotic tra. It appears that both the instructive end of the pathway upstream of tra as well as the executive end downstream of dsx are primary targets of evolutionary divergence, while the transduction part seems less prone to changes. We propose that this is a feature shared with many other signaling cascades that regulate developmental fates.

Published
2014

19. About females and males: continuity and discontinuity in flies

Author

Bopp, D and Bopp, D

Abstract

Through the decades of relentless and dedicated studies in Drosophila melanogaster, the pathway that governs sexual development has been elucidated in great detail and has become a paradigm in understanding fundamental cell-fate decisions. However, recent phylogenetic studies show that the molecular strategy used in Drosophila deviates in some important aspects from those found in other dipteran flies and suggest that the Drosophila pathway is likely to be a derivative of a simpler and more common principle. In this essay, I will discuss the evolutionary plasticity of the sex-determining pathway based on studies in the common housefly, Musca domestica. Diversification appears to primarily arise from subtle differences in the regulation of the key switch gene transformer at the top of the pathway. On the basis of these findings I propose a new idea on how the Drosophila pathway may have evolved from a more archetypal system such as in M. domestica. In essence, the arrival of an X counting mechanism mediated by Sex-lethal to compensate for X linked gene dose differences set the stage for an intimate coupling of the two pathways. Its precedent recruitment to the dosage compensation pathway allowed for an intervention in the regulation of transformer where it gradually and eventually' completely substituted for a need of transformer autoregulation.

Published
2010

20. Hormones and sex-specific transcription factors jointly control yolk protein synthesis in Musca domestica

Author

Siegenthaler, C, Maroy, P, Hediger, M, Dübendorfer, A, Bopp, D, Siegenthaler, C, Maroy, P, Hediger, M, Dübendorfer, A, and Bopp, D

Abstract

In the housefly Musca domestica, synthesis of yolk proteins (YPs) depends on the level of circulating ecdysteroid hormones. In female houseflies, the ecdysterone concentration in the hemolymph oscillates and, at high levels, is followed by expression of YP. In male houseflies, the ecdysterone titre is constantly low and no YP is produced. In some strains, which are mutant in key components of the sex-determining pathway, males express YP even though their ecdysterone titre is not significantly elevated. However, we find that these males express a substantial amount of the female variant of the Musca doublesex homologue, Md-dsx. The dsx gene is known to sex-specifically control transcription of yp genes in the fat body of Drosophila melanogaster. Our data suggest that Md-dsx also contributes to the regulation of YP expression in the housefly by modulating the responsiveness of YP-producing cells to hormonal stimuli.

Published
2009

22. The transformer2 gene in Musca domestica is required for selecting and maintaining the female pathway of development.

Author

Burghardt, G, Hediger, M, Siegenthaler, C, Moser, M, Dübendorfer, A, Bopp, D, Burghardt, G, Hediger, M, Siegenthaler, C, Moser, M, Dübendorfer, A, and Bopp, D

Abstract

We present the isolation and functional analysis of a transformer2 homologue Mdtra2 in the housefly Musca domestica. Compromising the activity of this gene by injecting dsRNA into embryos causes complete sex reversal of genotypically female individuals into fertile males, revealing an essential function of Mdtra2 in female development of the housefly. Mdtra2 is required for female-specific splicing of Musca doublesex (Mddsx) which structurally and functionally corresponds to Drosophila dsx, the bottom-most regulator in the sex-determining pathway. Since Mdtra2 is expressed in males and females, we propose that Mdtra2 serves as an essential co-factor of F, the key sex-determining switch upstream of Mddsx. We also provide evidence that Mdtra2 acts upstream as a positive regulator of F supporting genetic data which suggest that F relies on an autocatalytic activity to select and maintain the female path of development. We further show that repression of male courtship behavior by F requires Mdtra2. This function of F and Mdtra2 appears not to be mediated by Mddsx, suggesting that bifurcation of the pathway at this level is a conserved feature in the genetic architecture of Musca and Drosophila.

Published
2005

23. Sex determination in Drosophila melanogaster and Musca domestica converges at the level of the terminal regulator doublesex.

Author

Hediger, M, Burghardt, G, Siegenthaler, C, Buser, N, Hilfiker-Kleiner, D, Dübendorfer, A, Bopp, D, Hediger, M, Burghardt, G, Siegenthaler, C, Buser, N, Hilfiker-Kleiner, D, Dübendorfer, A, and Bopp, D

Abstract

Sex-determining cascades are supposed to have evolved in a retrograde manner from bottom to top. Wilkins' 1995 hypothesis finds support from our comparative studies in Drosophila melanogaster and Musca domestica, two dipteran species that separated some 120 million years ago. The sex-determining cascades in these flies differ at the level of the primary sex-determining signal and their targets, Sxl in Drosophila and F in Musca. Here we present evidence that they converge at the level of the terminal regulator, doublesex ( dsx), which conveys the selected sexual fate to the differentiation genes. The dsx homologue in Musca, Md-dsx, encodes male-specific (MdDSX(M)) and female-specific (MdDSX(F)) protein variants which correspond in structure to those in Drosophila. Sex-specific regulation of Md-dsx is controlled by the switch gene F via a splicing mechanism that is similar but in some relevant aspects different from that in Drosophila. MdDSX(F) expression can activate the vitellogenin genes in Drosophila and Musca males, and MdDSX(M) expression in Drosophila females can cause male-like pigmentation of posterior tergites, suggesting that these Musca dsx variants are conserved not only in structure but also in function. Furthermore, downregulation of Md-dsx activity in Musca by injecting dsRNA into embryos leads to intersexual differentiation of the gonads. These results strongly support a role of Md-dsx as the final regulatory gene in the sex-determining hierarchy of the housefly.

Published
2004

25. Public health approach to detection of non-O157 Shiga toxin-producingEscherichia coli: summary of two outbreaks and laboratory procedures

Author

SCHAFFZIN, J. K., primary, CORONADO, F., additional, DUMAS, N. B., additional, ROOT, T. P., additional, HALSE, T. A., additional, SCHOONMAKER-BOPP, D. J., additional, LURIE, M. M., additional, NICHOLAS, D., additional, GERZONICH, B., additional, JOHNSON, G. S., additional, WALLACE, B. J., additional, and MUSSER, K. A., additional

Published
2011
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26. Publisher’s Note: Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums [Phys. Rev. Lett.106, 085004 (2011)]

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, DuPuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T., additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzales, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D. A., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M.-Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T. E., additional, Milovich, J. L., additional, Miramontes-Ortiz, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendleton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strauser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. L., additional, Trummer, D. J., additional, Truong, J. H., additional, Vaher, J. L., additional, Valadez, M. C., additional, Van Arsdall, P. J., additional, Van Prooyen, A. J., additional, Vergel de Dios, E. O., additional, Vergino, M. D., additional, Vernon, S. P., additional, Vickers, J. L., additional, Villanueva, G. T., additional, Vitalich, M. A., additional, Vonhof, S. A., additional, Wade, F. E., additional, Wallace, R. J., additional, Warren, C. T., additional, Warrick, A. L., additional, Watkins, J., additional, Weaver, S., additional, Wegner, P. J., additional, Weingart, M. A., additional, Wen, J., additional, White, K. S., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilhelmsen, K., additional, Williams, E. A., additional, Williams, W. H., additional, Willis, L., additional, Wilson, E. F., additional, Wilson, B. A., additional, Witte, M. C., additional, Work, K., additional, Yang, P. S., additional, Young, B. K., additional, Youngblood, K. P., additional, Zacharias, R. A., additional, Zapata, P. G., additional, Zhang, H., additional, Zielinski, J. S., additional, Kline, J. L., additional, Kyrala, G. A., additional, Niemann, C., additional, Kilkenny, J. D., additional, Nikroo, A., additional, Van Wonterghem, B. M., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2011
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27. Demonstration of Ignition Radiation Temperatures in Indirect-Drive Inertial Confinement Fusion Hohlraums

Author

Glenzer, S. H., primary, MacGowan, B. J., additional, Meezan, N. B., additional, Adams, P. A., additional, Alfonso, J. B., additional, Alger, E. T., additional, Alherz, Z., additional, Alvarez, L. F., additional, Alvarez, S. S., additional, Amick, P. V., additional, Andersson, K. S., additional, Andrews, S. D., additional, Antonini, G. J., additional, Arnold, P. A., additional, Atkinson, D. P., additional, Auyang, L., additional, Azevedo, S. G., additional, Balaoing, B. N. M., additional, Baltz, J. A., additional, Barbosa, F., additional, Bardsley, G. W., additional, Barker, D. A., additional, Barnes, A. I., additional, Baron, A., additional, Beeler, R. G., additional, Beeman, B. V., additional, Belk, L. R., additional, Bell, J. C., additional, Bell, P. M., additional, Berger, R. L., additional, Bergonia, M. A., additional, Bernardez, L. J., additional, Berzins, L. V., additional, Bettenhausen, R. C., additional, Bezerides, L., additional, Bhandarkar, S. D., additional, Bishop, C. L., additional, Bond, E. J., additional, Bopp, D. R., additional, Borgman, J. A., additional, Bower, J. R., additional, Bowers, G. A., additional, Bowers, M. W., additional, Boyle, D. T., additional, Bradley, D. K., additional, Bragg, J. L., additional, Braucht, J., additional, Brinkerhoff, D. L., additional, Browning, D. F., additional, Brunton, G. K., additional, Burkhart, S. C., additional, Burns, S. R., additional, Burns, K. E., additional, Burr, B., additional, Burrows, L. M., additional, Butlin, R. K., additional, Cahayag, N. J., additional, Callahan, D. A., additional, Cardinale, P. S., additional, Carey, R. W., additional, Carlson, J. W., additional, Casey, A. D., additional, Castro, C., additional, Celeste, J. R., additional, Chakicherla, A. Y., additional, Chambers, F. W., additional, Chan, C., additional, Chandrasekaran, H., additional, Chang, C., additional, Chapman, R. F., additional, Charron, K., additional, Chen, Y., additional, Christensen, M. J., additional, Churby, A. J., additional, Clancy, T. J., additional, Cline, B. D., additional, Clowdus, L. C., additional, Cocherell, D. G., additional, Coffield, F. E., additional, Cohen, S. J., additional, Costa, R. L., additional, Cox, J. R., additional, Curnow, G. M., additional, Dailey, M. J., additional, Danforth, P. M., additional, Darbee, R., additional, Datte, P. S., additional, Davis, J. A., additional, Deis, G. A., additional, Demaret, R. D., additional, Dewald, E. L., additional, Di Nicola, P., additional, Di Nicola, J. M., additional, Divol, L., additional, Dixit, S., additional, Dobson, D. B., additional, Doppner, T., additional, Driscoll, J. D., additional, Dugorepec, J., additional, Duncan, J. J., additional, Dupuy, P. C., additional, Dzenitis, E. G., additional, Eckart, M. J., additional, Edson, S. L., additional, Edwards, G. J., additional, Edwards, M. J., additional, Edwards, O. D., additional, Edwards, P. W., additional, Ellefson, J. C., additional, Ellerbee, C. H., additional, Erbert, G. V., additional, Estes, C. M., additional, Fabyan, W. J., additional, Fallejo, R. N., additional, Fedorov, M., additional, Felker, B., additional, Fink, J. T, additional, Finney, M. D., additional, Finnie, L. F., additional, Fischer, M. J., additional, Fisher, J. M., additional, Fishler, B. T., additional, Florio, J. W., additional, Forsman, A., additional, Foxworthy, C. B., additional, Franks, R. M., additional, Frazier, T., additional, Frieder, G., additional, Fung, T., additional, Gawinski, G. N., additional, Gibson, C. R., additional, Giraldez, E., additional, Glenn, S. M., additional, Golick, B. P., additional, Gonzales, H., additional, Gonzales, S. A., additional, Gonzalez, M. J., additional, Griffin, K. L., additional, Grippen, J., additional, Gross, S. M., additional, Gschweng, P. H., additional, Gururangan, G., additional, Gu, K., additional, Haan, S. W., additional, Hahn, S. R., additional, Haid, B. J., additional, Hamblen, J. E., additional, Hammel, B. A., additional, Hamza, A. V., additional, Hardy, D. L., additional, Hart, D. R., additional, Hartley, R. G., additional, Haynam, C. A., additional, Heestand, G. M., additional, Hermann, M. R., additional, Hermes, G. L., additional, Hey, D. S., additional, Hibbard, R. L., additional, Hicks, D. G., additional, Hinkel, D. E., additional, Hipple, D. L., additional, Hitchcock, J. D., additional, Hodtwalker, D. L., additional, Holder, J. P., additional, Hollis, J. D., additional, Holtmeier, G. M., additional, Huber, S. R., additional, Huey, A. W., additional, Hulsey, D. N., additional, Hunter, S. L., additional, Huppler, T. R., additional, Hutton, M. S., additional, Izumi, N., additional, Jackson, J. L., additional, Jackson, M. A., additional, Jancaitis, K. S., additional, Jedlovec, D. R., additional, Johnson, B., additional, Johnson, M. C., additional, Johnson, T., additional, Johnston, M. P., additional, Jones, O. S., additional, Kalantar, D. H., additional, Kamperschroer, J. H., additional, Kauffman, R. L., additional, Keating, G. A., additional, Kegelmeyer, L. M., additional, Kenitzer, S. L., additional, Kimbrough, J. R., additional, King, K., additional, Kirkwood, R. K., additional, Klingmann, J. L., additional, Knittel, K. M., additional, Kohut, T. R., additional, Koka, K. G., additional, Kramer, S. W., additional, Krammen, J. E., additional, Krauter, K. G., additional, Krauter, G. W., additional, Krieger, E. K., additional, Kroll, J. J., additional, La Fortune, K. N., additional, Lagin, L. J., additional, Lakamsani, V. K., additional, Landen, O. L., additional, Lane, S. W., additional, Langdon, A. B., additional, Langer, S. H., additional, Lao, N., additional, Larson, D. W., additional, Latray, D., additional, Lau, G. T., additional, Le Pape, S., additional, Lechleiter, B. L., additional, Lee, Y., additional, Lee, T. L., additional, Li, J., additional, Liebman, J. A., additional, Lindl, J. D., additional, Locke, S. F., additional, Loey, H. K., additional, London, R. A., additional, Lopez, F. J., additional, Lord, D. M., additional, Lowe-Webb, R. R., additional, Lown, J. G., additional, Ludwigsen, A. P., additional, Lum, N. W., additional, Lyons, R. R., additional, Ma, T., additional, MacKinnon, A. J., additional, Magat, M. D., additional, Maloy, D. T., additional, Malsbury, T. N., additional, Markham, G., additional, Marquez, R. M., additional, Marsh, A. A., additional, Marshall, C. D., additional, Marshall, S. R., additional, Maslennikov, I. L., additional, Mathisen, D. G., additional, Mauger, G. J., additional, Mauvais, M. -Y., additional, McBride, J. A., additional, McCarville, T., additional, McCloud, J. B., additional, McGrew, A., additional, McHale, B., additional, MacPhee, A. G., additional, Meeker, J. F., additional, Merill, J. S., additional, Mertens, E. P., additional, Michel, P. A., additional, Miller, M. G., additional, Mills, T., additional, Milovich, J. L., additional, Miramontes, R., additional, Montesanti, R. C., additional, Montoya, M. M., additional, Moody, J., additional, Moody, J. D., additional, Moreno, K. A., additional, Morris, J., additional, Morriston, K. M., additional, Nelson, J. R., additional, Neto, M., additional, Neumann, J. D., additional, Ng, E., additional, Ngo, Q. M., additional, Olejniczak, B. L., additional, Olson, R. E., additional, Orsi, N. L., additional, Owens, M. W., additional, Padilla, E. H., additional, Pannell, T. M., additional, Parham, T. G., additional, Patterson, R. W., additional, Pavel, G., additional, Prasad, R. R., additional, Pendlton, D., additional, Penko, F. A., additional, Pepmeier, B. L., additional, Petersen, D. E., additional, Phillips, T. W., additional, Pigg, D., additional, Piston, K. W., additional, Pletcher, K. D., additional, Powell, C. L., additional, Radousky, H. B., additional, Raimondi, B. S., additional, Ralph, J. E., additional, Rampke, R. L., additional, Reed, R. K., additional, Reid, W. A., additional, Rekow, V. V., additional, Reynolds, J. L., additional, Rhodes, J. J., additional, Richardson, M. J., additional, Rinnert, R. J., additional, Riordan, B. P., additional, Rivenes, A. S., additional, Rivera, A. T., additional, Roberts, C. J., additional, Robinson, J. A., additional, Robinson, R. B., additional, Robison, S. R., additional, Rodriguez, O. R., additional, Rogers, S. P., additional, Rosen, M. D., additional, Ross, G. F., additional, Runkel, M., additional, Runtal, A. S., additional, Sacks, R. A., additional, Sailors, S. F., additional, Salmon, J. T., additional, Salmonson, J. D., additional, Saunders, R. L., additional, Schaffer, J. R., additional, Schindler, T. M., additional, Schmitt, M. J., additional, Schneider, M. B., additional, Segraves, K. S., additional, Shaw, M. J., additional, Sheldrick, M. E., additional, Shelton, R. T., additional, Shiflett, M. K., additional, Shiromizu, S. J., additional, Shor, M., additional, Silva, L. L., additional, Silva, S. A., additional, Skulina, K. M., additional, Smauley, D. A., additional, Smith, B. E., additional, Smith, L. K., additional, Solomon, A. L., additional, Sommer, S., additional, Soto, J. G., additional, Spafford, N. I., additional, Speck, D. E., additional, Springer, P. T., additional, Stadermann, M., additional, Stanley, F., additional, Stone, T. G., additional, Stout, E. A., additional, Stratton, P. L., additional, Strausser, R. J., additional, Suter, L. J., additional, Sweet, W., additional, Swisher, M. F., additional, Tappero, J. D., additional, Tassano, J. B., additional, Taylor, J. S., additional, Tekle, E. A., additional, Thai, C., additional, Thomas, C. A., additional, Thomas, A., additional, Throop, A. L., additional, Tietbohl, G. L., additional, Tillman, J. M., additional, Town, R. P. J., additional, Townsend, S. L., additional, Tribbey, K. L., additional, Trummer, D., additional, Truong, J., additional, Vaher, J., additional, Valadez, M., additional, Van Arsdall, P., additional, Van Prooyen, A. J., additional, Vergel de Dios, E. O., additional, Vergino, M. D., additional, Vernon, S. P., additional, Vickers, J. L., additional, Villanueva, G. T., additional, Vitalich, M. A., additional, Vonhof, S. A., additional, Wade, F. E., additional, Wallace, R. J., additional, Warren, C. T., additional, Warrick, A. L., additional, Watkins, J., additional, Weaver, S., additional, Wegner, P. J., additional, Weingart, M. A., additional, Wen, J., additional, White, K. S., additional, Whitman, P. K., additional, Widmann, K., additional, Widmayer, C. C., additional, Wilhelmsen, K., additional, Williams, E. A., additional, Williams, W. H., additional, Willis, L., additional, Wilson, E F., additional, Wilson, B. A., additional, Witte, M. C., additional, Work, K., additional, Yang, P. S., additional, Young, B. K., additional, Youngblood, K. P., additional, Zacharias, R. A., additional, Zaleski, T., additional, Zapata, P. G., additional, Zhang, H., additional, Zielinski, J. S., additional, Kline, J. L., additional, Kyrala, G. A., additional, Niemann, C., additional, Kilkenny, J. D., additional, Nikroo, A., additional, Van Wonterghem, B. M., additional, Atherton, L. J., additional, and Moses, E. I., additional

Published
2011
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28. The Prevalence of Multidrug Resistance Is Higher among Bovine than Human Salmonella enterica Serotype Newport, Typhimurium, and 4,5,12:i:− Isolates in the United States but Differs by Serotype and Geographic Region

Author

Hoelzer, K., primary, Soyer, Y., additional, Rodriguez-Rivera, L. D., additional, Cummings, K. J., additional, McDonough, P. L., additional, Schoonmaker-Bopp, D. J., additional, Root, T. P., additional, Dumas, N. B., additional, Warnick, L. D., additional, Gröhn, Y. T., additional, Wiedmann, M., additional, Baker, K. N. K., additional, Besser, T. E., additional, Hancock, D. D., additional, and Davis, M. A., additional

Published
2010
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30. Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome

Author

Bellotto, M, Bopp, D, Senti, K A, Burke, R, Deak, P, Maroy, P, Dickson, B J, Basler, K; https://orcid.org/0000-0003-3534-1529, Hafen, E, Bellotto, M, Bopp, D, Senti, K A, Burke, R, Deak, P, Maroy, P, Dickson, B J, Basler, K; https://orcid.org/0000-0003-3534-1529, and Hafen, E

Abstract

A collection of 1609 recessive P-lethal mutations on the third chromosome was tested in germline clones for effects on egg differentiation and embryonic development. In 164 lines, normal differentiation of the egg chamber is prevented and in 841 lines, embryos develop abnormally. This latter group of maternal-effect mutations was subdivided into 23 classes based on the cuticular phenotypes. Our collection comprises new alleles of previously characterized genes (e.g. kayak, punt, string, tramtrack). For some of the genes identified in this screen, a maternal contribution to embryonic development has not been described previously (e.g. extramacrochaete, Trithorax-like, single minded, couch potato, canoe). The genes classified in our study with a dual function during oogenesis and embryogenesis not only substantially extends the existing collection of maternal-effect genes but will also aid further understanding of how patterning of the Drosophila embryo is controlled by the maternal genome.

Published
2002

31. Musca domestica, a window on the evolution of sex-determining mechanisms in insects.

Author

Dübendorfer, A, Hediger, M, Burghardt, G, Bopp, D, Dübendorfer, A, Hediger, M, Burghardt, G, and Bopp, D

Abstract

The genetic cascades regulating sex determination of the housefly, Musca domestica, and the fruitfly, Drosophila melanogaster, appear strikingly different. The bifunctional switch gene doublesex, however, is present at the bottom of the regulatory cascades of both species, and so is transformer-2, one of the genetic elements required for the sex-specific regulation of doublesex. The upstream regulators are different: Drosophila utilizes Sex-lethal to coordinate the control of sex determination and dosage compensation, i.e., the process that equilibrates the difference of two X chromosomes in females versus one X chromosome in males. In the housefly, Sex-lethal is not involved in sex determination, and dosage compensation, if existent at all, is not coupled with sexual differentiation. This allows for more adaptive plasticity in the housefly system. Accordingly, natural housefly populations can vary greatly in their mechanism of sex determination, and new types can be generated in the laboratory.

Published
2002

34. A Multistate Outbreak of Serratia marcescens Bloodstream Infection Associated with Contaminated Intravenous Magnesium Sulfate from a Compounding Pharmacy

Author

Sunenshine, R. H., primary, Tan, E. T., additional, Terashita, D. M., additional, Jensen, B. J., additional, Kacica, M. A., additional, Sickbert-Bennett, E. E., additional, Noble-Wang, J. A., additional, Palmieri, M. J., additional, Bopp, D. J., additional, Jernigan, D. B., additional, Kazakova, S., additional, Bresnitz, E. A., additional, Tan, C. G., additional, and McDonald, L. C., additional

Published
2007
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38. Recombination and disjunction in female germ cells of Drosophila depend on the germline activity of the gene sex-lethal.

Author

Bopp, D, Schütt, C, Puro, J, Huang, H, Nöthiger, R, Bopp, D, Schütt, C, Puro, J, Huang, H, and Nöthiger, R

Abstract

Gametogenesis in males and females differs in many ways. An important difference in Drosophila is that recombination between homologous chromosomes occurs only in female meiosis. Here, we report that this process relies on the correct functioning of Sex-lethal (Sxl) which is primarily known as the master gene in somatic sex determination. Certain alleles of this gene (Sxl(fs)) disrupt the germline, but not the somatic function of Sxl and cause an arrest of germ cell development during cystocyte proliferation. Using dominant suppressor mutations that relieve this early block in Sxl(fs) mutant females, we discovered additional requirements of Sxl for normal meiotic differentiation of the oocyte. Females mutant for Sxl(fs) and carrying a suppressor become fertile, but pairing of homologous chromosomes and formation of chiasmata is severely perturbed, resulting in an almost complete lack of recombinants and a high incidence of non-disjunction events. Similar results were obtained when germline expression of wild-type Sxl was compromised by mutations in virilizer (vir), a positive regulator of Sxl. Ectopic expression of a Sxl transgene in premeiotic stages of male germline development, on the other hand, is not sufficient to allow recombination to take place, which suggests that Sxl does not have a discriminatory role in this female-specific process. We propose that Sxl performs at least two tasks in oogenesis: an 'early' function in formation of the egg chamber, and a 'late' function in progression of the meiotic cell cycle, suggesting that both events are coordinated by a common mechanism.

Published
1999

39. The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex-specifically regulated.

Author

Saccone, G, Peluso, I, Artiaco, D, Giordano, E, Bopp, D, Polito, L C, Saccone, G, Peluso, I, Artiaco, D, Giordano, E, Bopp, D, and Polito, L C

Abstract

In Drosophila, Sxl functions as a binary switch in sex determination. Under the control of the primary sex-determining signal, it produces functional protein only in XX animals to implement female development. Here we report that, in contrast to Drosophila, the Sxl homologue in the Medfly, Ceratitis capitata, expresses the same mRNAs and protein isoforms in both XX and XY animals irrespective of the primary sex-determining signal. Also, experiments with two inducible transgenes demonstrate that the corresponding Ceratitis SXL product has no significant sex-transforming effects when expressed in Drosophila. Similar results have been obtained for the Sxl homologue of Musca domestica (Meise, M., Hilfiker-Kleiner, D., Brunner, C., DŁbendorfer, A., N¿thiger, R. and Bopp, D. (1998) Development 125, 1487-1494). Our findings suggest that Sxl acquired its master regulatory role in sex determination during evolution of the Acalyptratae group, most probably after phylogenetic divergence of the genus Drosophila from other genera of this group.

Published
1998

40. Sex-specific control of Sex-lethal is a conserved mechanism for sex determination in the genus Drosophila.

Author

Bopp, D, Calhoun, G, Horabin, J I, Samuels, M, Schedl, P, Bopp, D, Calhoun, G, Horabin, J I, Samuels, M, and Schedl, P

Abstract

In D. melanogaster the binary switch gene Sex-lethal (Sxl) plays a pivotal role in somatic sex determination -- when the Sxl gene is on the female pathway is followed, while the male pathway is followed when the gene is off. In the present study we have asked whether the Sxl gene is present in other species of the genus Drosophila and whether it is subject to a similar sex-specific on-off regulation. Sxl proteins were found in all of the drosophilids examined, and they display a sex-specific pattern of expression. Furthermore, characterization of the Sxl gene in the distant drosophilan relative, D. virilis, reveals that the structure and sequence organization of the gene has been well conserved and that, like melanogaster, alternative RNA processing is responsible for its sex-specific expression. Hence, this posttranscriptional on-off regulatory mechanism probably existed before the separation of the drosophilan and sophophoran subgenera and it seems likely that Sxl functions as a sex determination switch gene in most species in the Drosophila genus. Although alternative splicing appears to be responsible for the on-off regulation of the Sxl gene in D. virilis, this species is unusual in that Sxl proteins are present not only in females but also in males. The D. virilis female and male proteins appear to be identical over most of the length except for the amino-terminal approx. 25 aa which are encoded by the differentially spliced exons. In transcriptionally active polytene chromosomes, the male and female proteins bind to the same cytogenetic loci, including the sites corresponding to the D. virilis Sxl and tra genes. Hence, though the male proteins are able to interact with appropriate target pre-mRNAs, they are apparently incapable of altering the splicing pattern of these pre-mRNAs.

Published
1996

42. Sex Determination in Insects: Variations on a Common Theme.

Author

Bopp, D., Saccone, G., and Beye, M.

Abstract

Recent studies in a representative selection of holometabolous insects suggest that, despite diversity at the instructive level, the signal-relaying part of the sex-determining pathway is remarkably well conserved. In principle, it is composed of the transformer gene (tra), which acts as a common binary switch that transduces the selected sexual fate, female when ON, male when OFF, to the downstream effector doublesex(dsx) that controls overt sexual differentiation. An interesting recurrent feature is that tra is switched ON in the early zygote by maternally provisioned tra activity. Different male-determining signals evolved, which prevent maternal activation of zygotic tra to allow for male development. In some species, where lack of maternal activation leaves tra in the OFF state, novel female-determining signals were deployed to activate zygotic tra. It appears that both the instructive end of the pathway upstream of tra as well as the executive end downstream of dsx are primary targets of evolutionary divergence, while the transduction part seems less prone to changes. We propose that this is a feature shared with many other signaling cascades that regulate developmental fates. © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
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