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5. Association of Neighborhood-Level Marginalization With Health Care Use and Clinical Outcomes Following Hospital Discharge in Patients Who Underwent Coronary Catheterization for Acute Myocardial Infarction in a Single-Payer Health Care System

Author

Akioyamen, Leo E., Abdel-Qadir, Husam, Han, Lu, Sud, Maneesh, Mistry, Nikhil, Alter, David A., Atzema, Clare L., Austin, Peter C., Bhatia, R. Sacha, Booth, Gillian L., Dhalla, Irfan, Ha, Andrew C.T., Jackevicius, Cynthia A., Kapral, Moira K., Krumholz, Harlan M., Lee, Douglas S., McNaughton, Candace D., Roifman, Idan, Schull, Michael J., Sivaswamy, Atul, Tu, Karen, Udell, Jacob A., Wijeysundera, Harindra C., and Ko, Dennis T.

Published
2023
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10. Need and Interest in Nature Prescriptions to Protect Cardiovascular and Mental Health: A Nationally-Representative Study With Insights for Future Randomised Trials

Author

Astell-Burt, Thomas, Hipp, J. Aaron, Gatersleben, Birgitta, Adlakha, Deepti, Marselle, Melissa, Olcoń, Katarzyna, Pappas, Evangelos, Kondo, Michelle, Booth, Gillian, Bacon, Simon, Lem, Melissa, Francois, Monique, Halcomb, Elizabeth, Moxham, Lorna, Davidson, Patricia, and Feng, Xiaoqi

Published
2023
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12. Rethinking walkability and developing a conceptual definition of active living environments to guide research and practice

Author

Tobin, Melissa, Hajna, Samantha, Orychock, Kassia, Ross, Nancy, DeVries, Megan, Villeneuve, Paul J., Frank, Lawrence D., McCormack, Gavin R., Wasfi, Rania, Steinmetz-Wood, Madeleine, Gilliland, Jason, Booth, Gillian L., Winters, Meghan, Kestens, Yan, Manaugh, Kevin, Rainham, Daniel, Gauvin, Lise, Widener, Michael J., Muhajarine, Nazeem, Luan, Hui, and Fuller, Daniel

Published
2022
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16. Persistent disparities in insulin pump uptake despite a universal pump programme for type 1 diabetes in Ontario, Canada.

Author

Soliman, Youstina, Everett, Karl, Shulman, Rayzel, Austin, Peter C., Lipscombe, Lorraine L., Booth, Gillian L., and Weisman, Alanna

Subjects
INSULIN pumps, TYPE 1 diabetes, INSULIN therapy, ODDS ratio, DATABASES
Abstract

Aim: To evaluate associations between social disadvantage and insulin pump use among adults with type 1 diabetes (T1D) in the context of a universal publicly funded insulin pump programme in Ontario, Canada, and to ascertain whether social disparities in insulin pump programme enrolment have decreased over time. Methods: Population‐based cross‐sectional studies were conducted using administrative healthcare data in Ontario, Canada. First, among adults aged older than 18 years diagnosed with T1D before 31 March 2021, logistic regression was used to assess the association between neighbourhood social disadvantage (Ontario marginalization index quintiles) and insulin pump use. Second, among all paediatric and adult applicants to the insulin pump programme from 1 September 2006 to 31 March 2022, ordinal logistic regression was used to evaluate associations between year of insulin pump initiation and social disadvantage. Results: Among 27 453 adults with T1D, 60% used insulin pumps. Greater social disadvantage was associated with lower odds of insulin pump use (adjusted odds ratio [OR] 0.44 [95% confidence interval {CI} 0.39‐0.48] for greatest vs. lowest social disadvantage quintile). Among 21 002 paediatric and adult applicants to the insulin pump programme, social disparities in pump use decreased in the first 3 years of the programme, plateaued until 2020, then increased from 2020 to 2022, with no change in the odds of being in a higher social deprivation quintile for 2022 relative to 2007 (OR 1.09 [95% CI 0.83‐1.44]). Conclusions: Despite a universal pump programme for individuals with T1D, disparities by social disadvantage persist. Residual financial and non‐financial barriers must be addressed to promote equitable insulin pump uptake. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Recent Improvements in Attainment of the Hemoglobin A1c Target of ≤7.0% Among Adults with Type 1 Diabetes in Ontario: A Retrospective Cohort Study.

Author

Weisman, Alanna, Booth, Gillian L., Everett, Karl, and Tomlinson, George A

Subjects
*TYPE 1 diabetes, *GENERALIZED estimating equations, *YOUNG adults, *GLYCEMIC control, *DIABETIC acidosis
Abstract

Aims: We evaluated attainment of the hemoglobin A1c (HbA1c) target of ≤7.0%, its temporal trends, and associated factors among adults with type 1 diabetes in Ontario, Canada, using administrative data. Methods: We conducted a retrospective cohort study, including Ontarians with type 1 diabetes ≥18 years old with ≥1 HbA1c test between April 1, 2012 (fiscal year 2013), and March 31, 2023. Generalized estimating equations were used to determine probabilities of meeting the HbA1c target, as well as associations between fiscal year and individual-, physician-, and system-level factors on odds of meeting the target. Results: Among 28,827 adults with type 1 diabetes [14,385 (49.9%) female, 17,998 (62.4%) pump users], with median age at index of 25 years [interquartile range (IQR) 18–37] and median diabetes duration of 12 years [6–18], there were 474,714 HbA1c tests [median 2/individual/year (IQR: 1–3)]. The model-estimated probability of meeting the HbA1c target of ≤7.0% was 22.1% (95% confidence interval, CI: 21.6 to 22.5) in 2013, remained stable until 2020, and increased to 34.7% (95% CI: 34.3 to 35.2) in 2023. The age- and sex-adjusted odds ratio for meeting the target in 2023 versus 2013 was 1.87 (95% CI: 1.79 to 1.96). Young adults (18–25 years), diabetic ketoacidosis, greater comorbidity, and receiving diabetes care from a nonspecialist physician were associated with reduced odds of meeting the HbA1c target. Conclusions: One-third of adults with type 1 diabetes in Ontario met the recommended HbA1c target of ≤7.0% in 2023, with improvement noted since 2021, which may be due to advanced technologies or effects of the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Long-term Neurobehavioral and Metabolic Outcomes in Offspring of Mothers With Diabetes During Pregnancy: A Large, Population-Based Cohort Study in Ontario, Canada.

Author

Feig, Denice S., Artani, Azmina, Asaf, Ayesha, Li, Ping, Booth, Gillian L., and Shah, Baiju R.

Subjects
TYPE 1 diabetes, GESTATIONAL diabetes, TYPE 2 diabetes, PROPORTIONAL hazards models, ATTENTION-deficit hyperactivity disorder
Abstract

OBJECTIVE: Offspring of women with diabetes are at increased risk of developing neurobehavioral and cardiometabolic disorders, but there is scant evidence regarding the association between glycemic level during pregnancy and these long-term offspring outcomes. RESEARCH DESIGN AND METHODS: We conducted a population-based, cohort study of deliveries in Ontario between April 1991 and March 2018. Women had preexisting diabetes, gestational diabetes, or no diabetes. We applied a Cox proportional hazard model to examine the risk of developing attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and cardiometabolic outcomes in offspring and assessed the association between pregnancy HbA1c levels and risk of outcomes, adjusting for confounders. RESULTS: A total of 3,407,961 mother-infant pairs were followed up to 29 years. Using a Cox proportional hazard model, offspring of women with type 1 diabetes had the highest risk of ADHD (adjusted hazard ratio [aHR] 1.43 [95% CI 1.36–1.49]), ASD (aHR 1.94 [1.80–2.09]), diabetes (aHR 4.73 [4.34–5.16]), hypertension (aHR 2.32 [2.07–2.61]), and cardiovascular disease (CVD) (aHR 1.72 [1.56–1.90]), followed by offspring of women with type 2 diabetes and gestational diabetes compared with those unexposed. Among women with preexisting diabetes, there was an association between level of pregnancy HbA1c and offspring diabetes (aHR 1.22 [95% CI 1.12–1.32]), hypertension (aHR 1.42 [1.29–1.57]), and CVD (aHR 1.20 [1.11–1.29]) but no statistically significant association with neurobehavioral outcomes. CONCLUSIONS: In utero exposure to maternal diabetes was associated with an increase in ADHD, ASD, and cardiometabolic outcomes in offspring, with differences seen across diabetes subtypes. Pregnancy glycemia was associated with cardiometabolic outcomes, but not neurobehavioral outcomes, and provides a potentially modifiable risk factor to decrease cardiometabolic outcomes in offspring. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases

Author

Rosenblum, Norman, Cefalu, William, Andersen, Dana K., Arreaza-Rubín, Guillermo, Dhara, Christine, James, Stephen P., Makarchuk, Mary-Jo, Pin, Christopher L., Sato, Sheryl, Verchere, Bruce, Woo, Minna, Powers, Alvin, Estall, Jennifer, Hoesli, Corrine, Millman, Jeffrey, Linnemann, Amelia, Johnson, James, Hawkins, Meredith, Gloyn, Anna, Huising, Mark O., Benninger, Richard K.P., Almaça, Joana, Hull-Meichle, Rebecca L., MacDonald, Patrick, Lynn, Francis, Melero-Martin, Juan, Yoshihara, Eiji, Stabler, Cherie, Sander, Maike, Evans-Molina, Carmella, Engin, Feyza, Thompson, Peter, Shalev, Anath, Redondo, Maria J., Nadeau, Kristen, Bellin, Melena, Udler, Miriam S., Dennis, John, Dash, Satya, Zhou, Wenyu, Snyder, Michael, Booth, Gillian, Butte, Atul, Florez, Jose, Cefalu, William T., Verchere, C. Bruce, and Rosenblum, Norman D.

Published
2021
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20. Time to SGLT2 Inhibitors Initiation in Patients With Heart Failure

Author

Moon, Jungyeon, primary, Udell, Jacob A., additional, Chong, Alice, additional, Fang, Jiming, additional, Austin, Peter C., additional, Ko, Dennis T., additional, Stukel, Therese A., additional, Atzema, Clare L., additional, Booth, Gillian L., additional, Tu, Karen, additional, Naimark, David M. J., additional, and Jackevicius, Cynthia A., additional

Published
2024
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22. Trends in the incidence of diagnosed diabetes: a multicountry analysis of aggregate data from 22 million diagnoses in high-income and middle-income settings

Author

Magliano, Dianna J, Chen, Lei, Islam, Rakibul M, Carstensen, Bendix, Gregg, Edward W, Pavkov, Meda E, Andes, Linda J, Balicer, Ran, Baviera, Marta, Boersma-van Dam, Elise, Booth, Gillian L, Chan, Juliana C N, Chua, Yi Xian, Fosse-Edorh, Sandrine, Fuentes, Sonsoles, Gulseth, Hanne L, Gurevicius, Romualdas, Ha, Kyoung Hwa, Hird, Thomas R, Jermendy, György, Khalangot, Mykola D, Kim, Dae Jung, Kiss, Zoltán, Kravchenko, Victor I, Leventer-Roberts, Maya, Lin, Chun-Yi, Luk, Andrea O Y, Mata-Cases, Manel, Mauricio, Didac, Nichols, Gregory A, Nielen, Mark M, Pang, Deanette, Paul, Sanjoy K, Pelletier, Catherine, Pildava, Santa, Porath, Avi, Read, Stephanie H, Roncaglioni, Maria Carla, Lopez-Doriga Ruiz, Paz, Shestakova, Marina, Vikulova, Olga, Wang, Kang-Ling, Wild, Sarah H, Yekutiel, Naama, and Shaw, Jonathan E

Published
2021
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26. Les defis de la gestion du diabete chez les personnes itinerantes: etude qualitative avec la methode photovoix

Author

Campbell, Rachel B., Larsen, Matthew, DiGiandomenico, Anna, Davidson, Marleane A., Booth, Gillian L., Hwang, Stephen W., McBrien, Kerry A., and Campbell, David J.T.

Subjects
Health
Abstract

CONTEXTE : La recherche sur les defis de la prise en charge du diabete chez les personnes itinerantes qui en sont atteintes n'a pas tendance a prendre en consideration le point de vue des personnes touchees. Nous avons utilise une approche de recherche participative avec la communaute pour explorer ces defis. METHODES : Nous avons recrute des cochercheurs ayant une connaissance experientielle de l'itinerance et du diabete. Les chercheurs principaux leur ont offert une formation en recherche et ont prepare le terrain avec eux pour ce projet. Les cochercheurs ont collectivement choisi d'utiliser la methode photovoix pour illustrer la difficulte de bien s'alimenter quand on est en situation d'itinerance et explorer en quoi cet ecueil affecte plus largement la gestion du diabete. Apres une formation en photographie et en ethique, les cochercheurs ont pris des photos en lien avec les objectifs du projet et redige des recits connexes au moyen de techniques de redaction inspiree par des photos. Les chercheurs principaux ont analyse les photos et les recits, et ils en ont degage des themes qui se sont precises lors de discussions de groupe. RESULTATS : Les 8 cochercheurs etaient atteints de diabete de type 2 (diagnostique de 18 mois a 23 ans auparavant) et avaient vecu en situation d'itinerance pendant des periodes allant de 8 mois a 12 ans. Nous avons degage 4 themes a partir de 17 photos et recits produits. L'itinerance affecte grandement la sante emotionnelle et mentale des personnes, ce qui nuit a leur capacite de bien gerer leur diabete. Les aliments servis dans les refuges sont rarement nutritifs ou appetissants. L'obtention d'une forme de logement peut faciliter la prise en charge du diabete en creant un environnement stable qui favorise l'autonomie, mais les couts et le manque de connaissances sont des obstacles a la preparation de repas sains. L'itinerance complique aussi l'acces aux professionnels de la prise en charge du diabete et aux medicaments d'ordonnance. INTERPRETATION : Les images et les recits associes permettent de dresser un tableau frappant, complet et fidele des defis auxquels sont confrontees les personnes en situation d'itinerance qui essaient de gerer leur diabete. Comprendre ces defis est la premiere etape qui permettra aux intervenants et aux decideurs de repondre aux besoins de cette population., Les patients diabetiques en situation d'itinerance ont souvent de la difficulte a gerer les taches d'autogestion en raison des multiples defis medicaux et sociaux auxquels ils sont confrontes (1). Cela [...]

Published
2021
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27. The challenges of managing diabetes while homeless: a qualitative study using photovoice methodology

Author

Campbell, Rachel B., Larsen, Matthew, DiGiandomenico, Anna, Davidson, Marleane A., Booth, Gillian L., Hwang, Stephen W., McBrien, Kerry A., and Campbell, David J.T.

Subjects
Homeless persons -- Care and treatment -- Beliefs, opinions and attitudes, Type 2 diabetes -- Care and treatment, Health
Abstract

BACKGROUND: Minimal consideration has been given to understanding the challenges of managing diabetes while homeless from the perspective of those with lived or living experience. We used a community-based participatory approach to explore these challenges. METHODS: We recruited coresearchers with experiential knowledge of both homelessness and diabetes. Lead researchers conducted research training and facilitated research development by coresearchers. Coresearchers collectively chose to use photovoice methodology to illustrate the challenges of accessing healthy food while homeless and to explore how homelessness more broadly affects diabetes management. After training in photography technique and ethics, coresearchers took photos to address these objectives and created accompanying narratives using photo elicitation techniques. Lead researchers analyzed photos and narratives, and extracted themes, refined through group discussion. RESULTS: The 8 coresearchers had type 2 diabetes (diagnosed 18 months to 23 years previously) and had experienced homelessness for periods ranging from 8 months to 12 years. We identified 4 themes from the 17 photos and narratives they produced. Homelessness imposed major demands on emotional and mental health, impairing the ability of those affected to focus on diabetes self-management. Foods provided in shelters were often nutritionally poor or unpalatable. Obtaining housing facilitated diabetes management through stability and autonomy, but cost and lack of knowledge posed challenges to healthy food preparation. Homelessness also presented challenges to accessing diabetes care professionals and prescription medications. INTERPRETATION: The images and narratives provide a powerful firsthand, in-depth account of the challenges faced by people trying to manage diabetes while homeless. Understanding these challenges is the first step in enabling providers and policy-makers to meet the needs of this population., Patients with diabetes who experience homelessness often have a difficult time with self-management tasks, given the various health and social challenges they face. (1) These include financial barriers to accessing [...]

Published
2021
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33. Association of Neighborhood‐Level Material Deprivation with Adverse Outcomes and Processes of Care Among Patients with Heart Failure in a Single‐Payer Healthcare System: A Population‐Based Cohort Study

Author

Bobrowski, David, primary, Dorovenis, Andrew, additional, Abdel‐Qadir, Husam, additional, McNaughton, Candace D., additional, Alonzo, Rea, additional, Fang, Jiming, additional, Austin, Peter C., additional, Udell, Jacob A., additional, Jackevicius, Cynthia A., additional, Alter, David A., additional, Atzema, Clare L., additional, Bhatia, R. Sacha, additional, Booth, Gillian L., additional, Ha, Andrew C.T., additional, Johnston, Sharon, additional, Dhalla, Irfan, additional, Kapral, Moira K., additional, Krumholz, Harlan M., additional, Roifman, Idan, additional, Wijeysundera, Harindra C, additional, Ko, Dennis T., additional, Tu, Karen, additional, Ross, Heather J., additional, Schull, Michael J., additional, and Lee, Douglas S., additional

Published
2023
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34. Understanding Whether and How a Digital Health Intervention Improves Transition Care for Emerging Adults Living With Type 1 Diabetes: Protocol for a Mixed Methods Realist Evaluation

Author

Wang, Ruoxi, primary, Rouleau, Geneviève, additional, Booth, Gillian Lynn, additional, Brazeau, Anne-Sophie, additional, El-Dassouki, Noor, additional, Taylor, Madison, additional, Cafazzo, Joseph A, additional, Greenberg, Marley, additional, Nakhla, Meranda, additional, Shulman, Rayzel, additional, and Desveaux, Laura, additional

Published
2023
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40. P22-010-23 Coronary Heart Effectiveness Assessment of the Portfolio Diet in Primary Care (CHEAP) Trial: Protocol for a Randomized Controlled Trial

Author

Chiavaroli, Laura, primary, Kavanagh, Meaghan, additional, Glenn, Andrea, additional, Chen, Victoria, additional, Back, Songhee, additional, Khan, Tauseef, additional, Chow, Chi-Ming, additional, Vallis, Michael, additional, Grant, Shannan, additional, Joy, Phillip, additional, Sherifali, Diana, additional, Agarwal, Payal, additional, Snelgrove-Clarke, Erna, additional, Juni, Peter, additional, DaCosta, Bruno, additional, Greiver, Michelle, additional, Pinto, Andrew, additional, Booth, Gillian, additional, Udell, Jacob, additional, Farkouh, Michael, additional, Chan, Brian, additional, Isaranuwatchai, Wanrudee, additional, Beyene, Joseph, additional, De Souza, Russel, additional, Malik, Vasanti, additional, El-Sohemy, Ahmed, additional, L'Abbe, Mary, additional, Lee, Jennifer, additional, Boucher, Beatrice, additional, Comelli, Elena, additional, Salas-Salvadó, Jordi, additional, Watson, William, additional, Josse, Robert, additional, Lofters, Aisha, additional, Rackal, Julia, additional, Holmes, Candice, additional, Srichaikul, Korbua, additional, Noble, Matt, additional, Symington, Amy, additional, St-Onge, Marie-Pierre, additional, Leiter, Lawrence, additional, Kendall, Cyril, additional, Jenkins, David, additional, and Sievenpiper, John, additional

Published
2023
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44. Text message-based intervention, Keeping in Touch (KiT), to support youth as they transition to adult type 1 diabetes care: a protocol for a multisite randomised controlled superiority trial

Author

Sanmugalingham, Geetha, primary, Mok, Elise, additional, Cafazzo, Joseph A, additional, Desveaux, Laura, additional, Brazeau, Anne-Sophie, additional, Booth, Gillian L, additional, Greenberg, Marley, additional, Kichler, Jessica, additional, Rac, Valeria E, additional, Austin, Peter, additional, Goldbloom, Ellen, additional, Henderson, Mélanie, additional, Landry, Alanna, additional, Zenlea, Ian, additional, Taylor, Madison, additional, Nakhla, Meranda, additional, and Shulman, Rayzel, additional

Published
2023
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46. Higher Neighborhood Drivability Is Associated With a Higher Diabetes Risk in Younger Adults: A Population-Based Cohort Study in Toronto, Canada

Author

den Braver, Nicolette R., primary, Beulens, Joline W.J., additional, Wu, C. Fangyun, additional, Fazli, Ghazal S., additional, Gozdyra, Peter, additional, Howell, Nicholas A., additional, Lakerveld, Jeroen, additional, Moin, John S., additional, Rutters, Femke, additional, Brug, Johannes, additional, Moineddin, Rahim, additional, and Booth, Gillian L., additional

Published
2023
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