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4. Characteristics and Clinical Outcomes of Patients Hospitalized for Acute Heart Failure Who Develop Atrial Fibrillation or Convert to Sinus Rhythm.

Author

ZANDIJK, ARIETJE J.L., BOORSMA, EVA M., TER MAATEN, JOZINE M., RIENSTRA, MICHIEL, and VOORS, ADRIAAN A.

Abstract

• Clear clinical guidance on the management of AF in the setting of AHF remains missing in the current AF and HF guidelines due to a paucity of data. • In patients hospitalized for AHF, only a few converted from AF to sinus rhythm or vice versa. This occurred mainly within the first 24 hours after hospital admission. • Although development of AF or persistent AF was associated with longer lengths of hospitalization, midterm mortality and readmission rates were similar in the AF groups. Atrial fibrillation (AF) is the most common sustained arrhythmia in acute heart failure (AHF), with a prevalence of approximately 35%. However, little is known about the clinical characteristics and outcomes of in-hospital conversion from AF to sinus rhythm and vice versa. In a post hoc secondary analysis of the randomized, double-blind, placebo-controlled PROTECT trial in patients with AHF, we identified 4 groups of patients: AF at admission and in-hospital conversion to sinus rhythm (n = 44); in-hospital development of AF (n = 31); persistent AF (n = 278); and continuous sinus rhythm (n = 410). Conversion from AF to sinus rhythm (13.7%) and from sinus rhythm to AF (7.0%) occurred only in a minority of patients. Patients with AF who converted to sinus rhythm were more often classified as being in New York Heart Association class IV, had higher heart rates and higher respiratory rates at hospital admission, whereas patients who developed AF were older, more likely to be female and had the highest ejection fractions compared to continuous sinus rhythm (all P < 0.05). Conversion to sinus rhythm or development of AF occurred mainly within the first 24 hours after hospital admission. Patients with persistent AF and those who developed AF had longer median lengths of hospital stay (8 vs 7 days; P < 0.001 and 9 vs 7 days; P < 0.001, respectively), compared to those with continuous sinus rhythm. In both univariable and multivariable analyses, there was no significant association between the AF groups and the primary clinical outcomes of either 180-day all-cause mortality or 60-day death or readmission for heart failure. In patients hospitalized for AHF, only few converted from AF to sinus rhythm or sinus rhythm to AF. Although development of AF or persistent AF was associated with longer lengths of hospitalization, midterm mortality and readmission rates were similar in the groups. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2025
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8. Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease

Author

Magagnoli, Lorenza, Cozzolino, Mario, Evans, Marie, Caskey, Fergus J., Dekker, Friedo W., Torino, Claudia, Szymczak, Maciej, Drechsler, Christiane, Pippias, Maria, Vilasi, Antonio, Janse, Roemer J., Krajewska, Magdalena, Stel, Vianda S., Jager, Kitty J., Chesnaye, Nicholas C., Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Butti, Alessandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Abaterusso, Cataldo, Somma, Chiara, D'alessandro, Claudia, Torino, Claudia, Zullo, Claudia, Pozzi, Claudio, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Russo, Domenico, Favaro, Enrico, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Greco, Gaetano, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Capizzi, Irene, Baragetti, Ivano, Oldrizzi, Lamberto, Gesualdo, Loreto, Biancone, Luigi, Magnano, Manuela, Ricardi, Marco, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Ferraresi, Martina, Provenzano, Michele, Malaguti, Moreno, Palmieri, Nicola, Murrone, Paola, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Cicchetti, Teresa, Rappa, Tiziana, Palazzo, Valentina, De Simone, Walter, Schrander, Anita, van Dam, Bastiaan, Siegert, Carl, Gaillard, Carlo, Beerenhout, Charles, Verburgh, Cornelis, Janmaat, Cynthia, Hoogeveen, Ellen, Hoorn, Ewout, Boots, Johannes, Boom, Henk, Eijgenraam, Jan-Willem, Kooman, Jeroen, Rotmans, Joris, Vogt, Liffert, Raasveld, Maarten, Vervloet, Marc, van Buren, Marjolijn, van Diepen, Merel, Leurs, Paul, Voskamp, Pauline, Blankestijn, Peter, van Esch, Sadie, Boorsma, Siska, Berger, Stefan, Konings, Constantijn, Aydin, Zeynep, Musiała, Aleksandra, Szymczak, Anna, Olczyk, Ewelina, Augustyniak-Bartosik, Hanna, Miśkowiec-Wiśniewska, Ilona, Manitius, Jacek, Pondel, Joanna, Jędrzejak, Kamila, Nowańska, Katarzyna, Nowak, Łukasz, Durlik, Magdalena, Dorota, Szyszkowska, Nieszporek, Teresa, Heleniak, Zbigniew, Jonsson, Andreas, Blom, Anna-Lena, Rogland, Björn, Wallquist, Carin, Vargas, Denes, Dimény, Emöke, Sundelin, Fredrik, Uhlin, Fredrik, Welander, Gunilla, Hernandez, Isabel Bascaran, Gröntoft, Knut-Christian, Stendahl, Maria, Svensson, Maria, Evans, Marie, Heimburger, Olof, Kashioulis, Pavlos, Melander, Stefan, Almquist, Tora, Jensen, Ulrika, Woodman, Alistair, McKeever, Anna, Ullah, Asad, McLaren, Barbara, Harron, Camille, Barrett, Carla, O'Toole, Charlotte, Summersgill, Christina, Geddes, Colin, Glowski, Deborah, McGlynn, Deborah, Sands, Dympna, Roy, Geena, Hirst, Gillian, King, Hayley, McNally, Helen, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Turner, Jane, Wilcox, Joanne, Berdeprado, Jocelyn, Wong, Jonathan, Banda, Joyce, Jones, Kirsteen, Haydock, Lesley, Wilkinson, Lily, Carmody, Margaret, Weetman, Maria, Joinson, Martin, Dutton, Mary, Matthews, Michael, Morgan, Neal, Bleakley, Nina, Cockwell, Paul, Roderick, Paul, Mason, Phil, Kalra, Philip, Sajith, Rincy, Chapman, Sally, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Mathavakkannan, Suresh, and Kuan, Ying

Published
2024
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14. Longitudinal Changes in Circulating Ketone Body Levels in Patients With Acute Heart Failure: A Post Hoc Analysis of the EMPA-Response-AHF Trial.

Author

Voorrips, S.N., BOORSMA, E.M., BEUSEKAMP, J.C., DE-BOER, R.A., CONNELLY, M.A., DULLAART, R.P.F., VAN-DER-MEER, P., VAN-VELDHUISEN, D.J., VOORS, A.A., DAMMAN, K., and WESTENBRINK, B.D.

Abstract

Background: Ketone bodies are endogenous fuels produced by the liver under conditions of metabolic or neurohormonal stress. Circulating ketone bodies are increased in patients with chronic heart failure (HF), yet little is known about the effect of acute HF on ketosis. We tested the hypothesis that ketogenesis is increased in patients with acute decompensated HF.Methods and Results: This was a post hoc analysis of 79 patients with acute HF included in the EMPA-RESPONSE-AHF trial, which compared sodium-dependent glucose-cotransporter protein 2 inhibitor treatment with empagliflozin for 30 days with placebo in patients with acute HF [NCT03200860]. Plasma concentrations of ketone bodies acetone, β-hydroxybutyrate, and acetoacetate were measured at baseline and 5 different timepoints. Changes in ketone bodies over time were monitored using repeated measures analysis of variance. In the total cohort, median total ketone body concentration was 251 µmol/L (interquartile range, 178-377 µmol/L) at baseline, which gradually decreased to 202 µmol/L (interquartile range, 156-240 µmol/L) at day 30 (P = .041). Acetone decreased from 60 µmol/L (interquartile range, 34-94 µmol/L) at baseline to 30 µmol/L (interquartile range, 21-42 µmol/L) ( P < .001), whereas β-hydroxybutyrate and acetoacetate remained stable over time. Higher acetone concentrations were correlated with higher N-terminal pro brain natriuretic peptide levels (r = 0.234; P = .039). Circulating ketone bodies did not differ between patients treated with empagliflozin or placebo throughout the study period. A higher acetone concentration at baseline was univariately associated with a greater risk of the composite end point, including in-hospital worsening HF, HF rehospitalizations, and all-cause mortality after 30 days. However, after adjustment for age and sex, acetone did not remain an independent predictor for the combined end point.Conclusions: Circulating ketone body concentrations, and acetone in particular, were significantly higher during an episode of acute decompensated HF compared with after stabilization. Treatment with empagliflozin did not affect ketone body concentrations in patients with acute HF. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Symptom Burden before and after Dialysis Initiation in Older Patients

Author

de Rooij, Esther N.M., Meuleman, Yvette, de Fijter, Johan W., Jager, Kitty J., Chesnaye, Nicholas C., Evans, Marie, Caskey, Fergus J., Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Dekker, Friedo W., Hoogeveen, Ellen K., Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Drechsler, Christiane, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Alessandra, Butti, Abaterusso, Cataldo, Somma, Chiara, D’alessandro, Claudia, Torino, Claudia, Zullo, Claudia, Pozzi, Claudio, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Russo, Domenico, Favaro, Enrico, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Greco, Gaetano, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Capizzi, Irene, Baragetti, Ivano, Oldrizzi, Lamberto, Gesualdo, Loreto, Biancone, Luigi, Magnano, Manuela, Ricardi, Marco, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Ferraresi, Martina, Provenzano, Michele, Malaguti, Moreno, Palmieri, Nicola, Murrone, Paola, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Cicchetti, Teresa, Rappa, Tiziana, Palazzo, Valentina, De Simone, Walter, Schrander, Anita, van Dam, Bastiaan, Siegert, Carl, Gaillard, Carlo, Beerenhout, Charles, Verburgh, Cornelis, Janmaat, Cynthia, Hoogeveen, Ellen, Hoorn, Ewout, Dekker, Friedo, Boots, Johannes, Boom, Henk, Eijgenraam, Jan-Willem, Kooman, Jeroen, Rotmans, Joris, Jager, Kitty, Vogt, Liffert, Raasveld, Maarten, Vervloet, Marc, van Buren, Marjolijn, van Diepen, Merel, Chesnaye, Nicholas, Leurs, Paul, Voskamp, Pauline, Blankestijn, Peter, van Esch, Sadie, Boorsma, Siska, Berger, Stefan, Konings, Constantijn, Aydin, Zeynep, Musiała, Aleksandra, Szymczak, Anna, Olczyk, Ewelina, Augustyniak-Bartosik, Hanna, Miśkowiec-Wiśniewska, Ilona, Manitius, Jacek, Pondel, Joanna, Jędrzejak, Kamila, Nowańska, Katarzyna, Nowak, Łukasz, Szymczak, Maciej, Durlik, Magdalena, Dorota, Szyszkowska, Nieszporek, Teresa, Heleniak, Zbigniew, Jonsson, Andreas, Blom, Anna-Lena, Rogland, Björn, Wallquist, Carin, Vargas, Denes, Dimény, Emöke, Sundelin, Fredrik, Uhlin, Fredrik, Welander, Gunilla, Hernandez, Isabel Bascaran, Gröntoft, Knut-Christian, Stendahl, Maria, Svensson, Maria, Evans, Marie, Heimburger, Olof, Kashioulis, Pavlos, Melander, Stefan, Almquist, Tora, Jensen, Ulrika, Woodman, Alistair, McKeever, Anna, Ullah, Asad, McLaren, Barbara, Harron, Camille, Barrett, Carla, O'Toole, Charlotte, Summersgill, Christina, Geddes, Colin, Glowski, Deborah, McGlynn, Deborah, Sands, Dympna, Caskey, Fergus, Roy, Geena, Hirst, Gillian, King, Hayley, McNally, Helen, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Turner, Jane, Wilcox, Joanne, Berdeprado, Jocelyn, Wong, Jonathan, Banda, Joyce, Jones, Kirsteen, Haydock, Lesley, Wilkinson, Lily, Carmody, Margaret, Weetman, Maria, Joinson, Martin, Dutton, Mary, Matthews, Michael, Morgan, Neal, Bleakley, Nina, Cockwell, Paul, Roderick, Paul, Mason, Phil, Kalra, Philip, Sajith, Rincy, Chapman, Sally, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Mathavakkannan, Suresh, and Kuan, Ying

Published
2022
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30. Pelvic Floor Rehabilitation After Rectal Cancer Surgery

Author

van der Heijden, J. A. G., Kalkdijk-Dijkstra, A. J., Pierie, J. P. E. N., van Westreenen, H. L., Broens, P. M. A., Klarenbeek, B. R., de Wilt, JHW, Stommel, MWJ, Bremers, AJA, Rosman, C, de Reuver, PR, Bouwense, SAW, van der Kolk, BM, Garms, LM, Meerten-van den Belt, K, Olde Hartman-Hofste, MRM, Peters, JWM, Olsder, L, Huizing, I, Trzpis, M, Furnee, EJB, Havenga, K, Hemmer, PHJ, van Etten, B, Koop, A, van der Heide, L, Kamphuis, D, Koopal, SA, Hoff, C, Eker, H, Junte, HHM, Schoenaker, IJH, Quaedackers, S, Bos, MJ, Gardien, H, van Sprundel, TC, de Vries, PD, Ashruf, JF, Geurts, L, Nielen, I, Pfeil, J, van Ark, M, Polle, SW, Hansson, B, Polat, F, de Vries, H, ten Berge-Groen, E, Talsma, AK, Bosker, R, Veurink, E, Papa, M, Maaskant-Braat, AJG, van den Broek, FJC, Leclercq, WKG, Slooter, GD, Caers, F, Boeijen, M, van den Broek, R, van Schaik, K, Wasowicz-Kemps, DK, Langenhoff, BS, van den Bogaard, MJ, van der Sluis, J, Arisz, D, Bruinsma, S, Hess, DA, Mulder, EJ, Wiering, B, Kok, S, Woltering, J, Raap-van Sleuwen, B, Schoonderwoerd, L, Hendriks, D, van den Elzen, N, van de Laak, I, Valk, M, van der Meij, W, van Wely, BJ, van Hoogstraten, MJ, van der Sluis, M, Paulusma, I, Mollers, MJW, Looijen, R, van der Mijle, HCJ, Pereboom, ITA, Tijink-Callenbach, PMC, Schasfoort, RA, van der Hagen, SJ, van de Meer, W, Lubberink, M, van Haskera, M, Wit, F, Jeeninga, M, ten Hoeve, R, Slootmans, FCW, Inberg, B, de Nes, L, Toonen, D, Wilmsen, MA, Buyne, O, Ferenschild, F, de Vries, M., Adamse, C, Hettema-Beets, BL, Goudswaard, MK, van der Velde, M, Elving, DW, Arends-Smit, RE, Buiter, JR, van der itte-van Aerle, I, Jansma, K, Kooistra, L, Lohof-Venema, S, Kruijer, MR, Dijkstra, G, van der erf-Elling, MA, Kats-de Boer, V, Rinsema, AM, Haarlemmer-Lutjeboer, M, van der Vegt, A, Berends-Pors, SMH, Ponstein, AJ, Klaassen, G, Nieuwint, AM, Veninga-Jansen, M, Dries-Jansen, V, Arends, FJ, Stellingwerf-Goinga, NE, Overmars, NG, van Asma, H, Beverdam, K, Ploumen, MJAC, Tijhuis, M, Visser Duiven, AH, Former, M, Smans-Kaal, MAL, Vorsterman van Oijen-Linthorst, CMJ, Hovels-Kamp, NN, Vorsteveld, LR, Vermeulen, N, Alkemade-van Veghel, A, Steentjes, LJ, Cornelisse-Theunissen, HGM, Strijbosch, J, Sniekers, S, Oerlemans-van Oijen, JMA, Hoefnagels, HMJ, Sniekers, CJDA, Biemans, S, Bomert-Wendt, Y, van Gaal, HGM, Smulders, AHCW, Adams, W, Kappen, JM, Vermeltfoort-Jansen, AM, Zegger, MGC, Vrielink, C, Slotman, HM, Claessens, NJH, Manders-de Groot, AWM, van Beuzekom-van der Vorst, CTPG, Swinkels-Nijssen, MWC, van Oeveren, P, van Leeuwen-Nellestijn, JPF, Bleijenberg, M, Valenteyn-Hidden, JJF, van Rutten-de Groot, MG, van den van der Heijden, M, Nieuwenhuizen, Boorsma, PG, Broodman, N, Elling, ME, Bokkers-Engelen, E, Hilhorst-Droppers, GH, Mein, HJC, and Gielen, M

Published
2022
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33. Renal Compression in Heart Failure

Author

Boorsma, Eva M., ter Maaten, Jozine M., Voors, Adriaan A., and van Veldhuisen, Dirk J.

Abstract

Renal dysfunction is one of the strongest predictors of outcome in heart failure. Several studies have revealed that both reduced perfusion and increased congestion (and central venous pressure) contribute to worsening renal function in heart failure. This paper proposes a novel factor in the link between cardiac and renal dysfunction: “renal tamponade” or compression of renal structures caused by the limited space for expansion. This space can be limited either by the rigid renal capsule that encloses the renal interstitial tissue or by the layer of fat around the kidneys or by the peritoneal space exerting pressure on the retroperitoneal kidneys. Renal decapsulation in animal models of heart failure and acute renal ischemia has been shown effective in alleviating pressure-related injury within the kidney itself, thus supporting this concept and making it a potentially interesting novel treatment in heart failure.

Published
2022
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37. Kidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD

Author

Ramspek, Chava L., Evans, Marie, Wanner, Christoph, Drechsler, Christiane, Chesnaye, Nicholas C., Szymczak, Maciej, Krajewska, Magdalena, Torino, Claudia, Porto, Gaetana, Hayward, Samantha, Caskey, Fergus, Dekker, Friedo W., Jager, Kitty J., van Diepen, Merel, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Musiała, Aleksandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Woodman, Alistair, Ranghino, Andrea, Stucchi, Andrea, Jonsson, Andreas, Schneider, Andreas, Pignataro, Angelo, Schrander, Anita, Torp, Anke, McKeever, Anna, Szymczak, Anna, Blom, Anna-Lena, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Ullah, Asad, McLaren, Barbara, van Dam, Bastiaan, Iwig, Beate, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Rogland, Björn, Perras, Boris, Alessandra, Butti, Harron, Camille, Wallquist, Carin, Siegert, Carl, Barrett, Carla, Gaillard, Carlo, Garofalo, Carlo, Abaterusso, Cataldo, Beerenhout, Charles, O’Toole, Charlotte, Somma, Chiara, Marx, Christian, Summersgill, Christina, Blaser, Christof, D’alessandro, Claudia, Emde, Claudia, Zullo, Claudia, Pozzi, Claudio, Geddes, Colin, Verburgh, Cornelis, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Glowski, Deborah, McGlynn, Deborah, Vargas, Denes, Krieter, Detlef, Russo, Domenico, Fuchs, Dunja, Sands, Dympna, Hoogeveen, Ellen, Irmler, Ellen, Dimény, Emöke, Favaro, Enrico, Platen, Eva, Olczyk, Ewelina, Hoorn, Ewout, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Sundelin, Fredrik, Uhlin, Fredrik, Greco, Gaetano, Roy, Geena, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Hirst, Gillian, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Welander, Gunilla, Augustyniak-Bartosik, Hanna, Boots, Hans, Schmidt-Gürtler, Hans, King, Hayley, McNally, Helen, Schlee, Hendrik, Boom, Henk, Naujoks, Holger, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Miśkowiec-Wiśniewska, Ilona, Schlee, Ines, Capizzi, Irene, Bascaran Hernandez, Isabel, Baragetti, Ivano, Manitius, Jacek, Turner, Jane, Eijgenraam, Jan-Willem, Kooman, Jeroen, Beige, Joachim, Pondel, Joanna, Wilcox, Joanne, Berdeprado, Jocelyn, Röthele, Jochen, Wong, Jonathan, Rotmans, Joris, Banda, Joyce, Mazur, Justyna, Hahn, Kai, Jędrzejak, Kamila, Nowańska, Katarzyna, Blouin, Katja, Neumeier, Katrin, Jones, Kirsteen, Anding-Rost, Kirsten, Gröntoft, Knut-Christian, Oldrizzi, Lamberto, Haydock, Lesley, Vogt, Liffert, Wilkinson, Lily, Gesualdo, Loreto, Schramm, Lothar, Biancone, Luigi, Nowak, Łukasz, Raasveld, Maarten, Durlik, Magdalena, Magnano, Manuela, Vervloet, Marc, Ricardi, Marco, Carmody, Margaret, Di Bari, Maria, Laudato, Maria, Luisa Sirico, Maria, Stendahl, Maria, Svensson, Maria, Weetman, Maria, van Buren, Marjolijn, Joinson, Martin, Ferraresi, Martina, Dutton, Mary, van Diepen, Merel, Matthews, Michael, Provenzano, Michele, Hopf, Monika, Malaguti, Moreno, Wuttke, Nadja, Morgan, Neal, Palmieri, Nicola, Frischmuth, Nikolaus, Bleakley, Nina, Murrone, Paola, Cockwell, Paul, Leurs, Paul, Roderick, Paul, Voskamp, Pauline, Kashioulis, Pavlos, Ichtiaris, Pawlos, Blankestijn, Peter, Kirste, Petra, Schulz, Petra, Mason, Phil, Kalra, Philip, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Sajith, Rincy, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Aign, Sabine, Cäsar, Sabine, van Esch, Sadie, Chapman, Sally, Biribauer, Sandra, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Manan, Sherin, Röser, Silke, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Boorsma, Siska, Heidenreich, Stefan, Melander, Stefan, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Palm, Stephanie, Konings, Stijn, Mathavakkannan, Suresh, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Dorota, Szyszkowska, Cicchetti, Teresa, Nieszporek, Teresa, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Rappa, Tiziana, Almquist, Tora, Stövesand, Torsten, Bahner, Udo, Jensen, Ulrika, Palazzo, Valentina, De Simone, Walter, Seeger, Wolfgang, Kuan, Ying, Heleniak, Zbigniew, and Aydin, Zeynep

Published
2021
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38. Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study

Author

de Rooij SR, Dekker, Jm, Kozakova, M, Mitrakou, A, Melander, O, Gabriel, R, Guidone, C, Højlund, K, Murphy, Ms, Nijpels, G, Dekker, J, de Rooij, S, Boorsma, P, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie, Jr, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Raisanen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, S, Sánchez, Me, Carraro, R, Friera, A, Perez, S, Nilsson, P, Persson, M, Ostling, G, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Beck Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Gb, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Mingrone, G, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofe, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Mari, A, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Landucci, L, Hills, S, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Mota, Epidemiology and Data Science, General practice, and EMGO - Lifestyle, overweight and diabetes

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Cohort Studies, Endocrinology, Insulin resistance, Internal medicine, Prevalence, medicine, Hyperinsulinemia, Humans, Insulin, Ultrasonography, Metabolic Syndrome, Glucose tolerance test, medicine.diagnostic_test, business.industry, Metabolic Syndrome X, Fasting, General Medicine, Odds ratio, Glucose Tolerance Test, Middle Aged, Glucose clamp technique, medicine.disease, Cardiovascular Diseases, Europe, Female, Glucose Clamp Technique, Insulin Resistance, Tunica Media, Intima-media thickness, Metabolic syndrome, business
Abstract

ObjectiveFasting insulin concentrations are often used as a surrogate measure of insulin resistance. We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis.Design and methodsThe Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic, overall healthy men and women aged 30–60 years. We performed standard oral glucose tolerance tests and hyperinsulinemic euglycemic clamps. As a general measure of cardiovascular risk, we assessed the prevalence of the metabolic syndrome in 1177 participants. Carotid artery intima media thickness (IMT) was measured by ultrasound to assess preclinical atherosclerosis.ResultsFasting insulin was correlated with all elements of the metabolic syndrome. Insulin sensitivity (M/I) was correlated with most elements. The odds ratio for the metabolic syndrome of those in the highest quartile of fasting insulin compared with those in the lower quartiles was 5.4 (95% confidence interval (CI) 2.8–10.3, adjusted for insulin sensitivity) in men and 5.1 (2.6–9.9) in women. The odds ratio for metabolic syndrome of those with insulin sensitivity in the lowest quartile of the cohort compared with those in the higher quartiles was 2.4 (95% CI 1.3–4.7, adjusted for fasting insulin) in men and 1.6 (0.8–3.1) in women. Carotid IMT was only statistically significantly associated with fasting insulin in both men and women.ConclusionsFasting insulin, a simple and practical measure, may be a stronger and independent contributor to cardiometabolic risk and atherosclerosis in a healthy population than hyperinsulinemic euglycemic clamp-derived insulin sensitivity.

Published
2009
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43. Liever geen nat pak overzee : drie waterbedrijven over MVO-risico's in het buitenland?

Author

Boorsma, P. and Boorsma, P.

Abstract

Ze halen een fors deel van hun omzet in het buitenland. Nederlandse kennisinstellingen, ingenieurs- en adviesbureaus werken daar aan projecten met grote impact op de omgeving. Dat kan leiden tot lokaal protest en mogelijk: reputatieschade. Wat doen de waterbedrijven om dit te voorkomen en hoe wegen zij de belangen af? Drie bedrijven vertellen hun verhaal. Plus: de praktijk in Indonesië.

Published
2017

44. Waarom heeft Nederland geen mooie fonteinen? : dat gaat snel veranderen

Author

Boorsma, P. and Boorsma, P.

Abstract

In alle grote steden in het buitenland zijn imposante, beeldbepalende fonteinen te vinden. Nederland moet het doen met wat sproeiertjes en bedriegertjes. Hoe komt het dat het verleden ons als waterland geen fonteinen van enige betekenis heeft opgeleverd? En komt daarin de komende jaren verandering?

Published
2017

46. Mensen: gewoontedieren

Author

Boorsma, P.

Subjects
HOI - Human Behaviour & Organisational Innovations, Human & Operational Modelling, ELSS - Earth, Life and Social Sciences, Behavioural influence, Healthy Living
Abstract

Als de overheid het beslisgedrag van burgers begrijpt, kan ze betere ondersteuning bieden, stelt hoogleraar psychologische besliskunde José Kerstholt van de Universiteit Twente. ‘Met dat inzicht kun je meer mensen laten participeren.’ Interview met José Kerstholt over gedrachtsbeïnvloeding

Published
2015

47. Drones : nieuwe hulpjes in de watersector

Author

Boorsma, P. and Boorsma, P.

Abstract

Menig jongenshart gaat er sneller van kloppen: drones, ofwel onbemande luchtvaartuigen. Ook in de watersector wordt volop geëxperimenteerd met deze toestellen. Welke toepassingsmogelijkheden zijn al bedacht? En welke kunnen we nog verwachten?

Published
2016

48. Gemeente! Wees nou eerlijk tegen je burgers : thema water & de gemeente

Author

Boorsma, P. and Boorsma, P.

Abstract

De gemeentelijke waterbeheerder van weleer is niet meer. Problemen veroorzaakt door extreme regenbuien en langere droogteperiodes zijn niet meer op te lossen door technische ingrepen alleen. Dus moet de gemeentelijk ‘rioleur’ uit zijn schulp komen, samenwerking zoeken, maar vooral ook: bewoners uitleggen wat wél en wat niet kan.

Published
2016

49. Talentenjacht! : hoe doen waterbedrijven dat? : thema water & werk

Author

Boorsma, P. and Boorsma, P.

Abstract

De watersector vergrijst en er dreigt tekort aan goed geschoold technisch personeel. Wat doen bedrijven in de sector om jonge mensen te werven en medewerkers aan zich te binden? Welke strategie hanteren ze?

Published
2016

50. Lieve Declercq (Vitens): het grondwater is ook van onze kleinkinderen

Author

Boorsma, P. and Boorsma, P.

Abstract

Sinds 2012 is Lieve Declercq directievoorzitter van drinkwaterbedrijf Vitens. Ze mengt zich in de discussies over schaliegas, mestbeleid en innovatie. Haar eigen organisatie moet denken in termen van de klant. “Met dezelfde excellence waarmee we drinkwater produceren, willen we ook de klant van dienst zijn.” De achttiende aflevering van een reeks met hoofdrolspelers in de watersector.

Published
2016

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