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9. Clausena harmandiana root extract ameliorates Aβ1-42 induced cognitive deficits, oxidative stress, and apoptosis in rats.

Author

Pannangrong, Wanassanun, Nillert, Nutchareeporn, Boonyarat, Chantana, Welbat, Jariya Umka, Yannasithinon, Supataechasit, and Choowong-In, Pannawat

Subjects
PROTEIN metabolism, NEUROPROTECTIVE agents, VITAMIN C, DATA analysis, RESEARCH funding, APOPTOSIS, PLANT roots, OXIDATIVE stress, DESCRIPTIVE statistics, PLANT extracts, RATS, MEDICINAL plants, COGNITION disorders, ANIMAL experimentation, GENE expression profiling, ANALYSIS of variance, STATISTICS, STAINS & staining (Microscopy), DATA analysis software, BIOMARKERS, CASPASES, MEMORY disorders, PHARMACODYNAMICS
Abstract

Background: Clausena harmandiana (CH), commonly known as song fa dong, was a medicinal plant traditionally used to treat illnesses and as a health tonic. CH root extract (CHRE) exhibited various bioactivities, including neuroprotective, antioxidant, antimicrobial, antifungal, anti-inflammatory, and anti-cancer effects. However, CHRE data on neuroprotective in AD-like animal models were still scarce. Objectives: This study aimed to investigate the effects of CHRE on Aβ1-42-induced cognitive deficits, free radical damage, and neuronal death in rats. Methods: Forty-eight adult male Sprague-Dawley rats (250–300 g) were classified as sham control (SC), V+Aβ, Vit C+Aβ, CHRE125+Aβ, CHRE250+Aβ, and CHRE500+Aβ (n = 8 in each group). Animals were orally administered with 0.5% sodium carboxymethylcellulose, vitamin C (200 mg/kg BW), or CHRE (125, 250, and 500 mg/kg BW) and were untreated for 35 days. On day 21, all treated rats were injected with 1 µl of aggregated Aβ1-42 (1 µg/µl) into the lateral ventricles, bilaterally, whereas untreated rats were injected with sterilized normal saline (NS). The Morris water maze test estimated the rat's learning and memory one week later. At the end of the treatment, all rats were sacrificed, and their brains were removed and divided into two hemispheres. On the left, morphological changes and neuronal density were observed in hippocampal CA1 and CA3 regions. While, on the right, changes in free radical damage markers (SOD, CAT, GPx, MDA, and Nrf2) and protein expression of active caspase-3 were evaluated in the hippocampus. Results: Pretreatment with CHRE at all doses could alleviate spatial learning and memory defects. CHRE also improved morphological changes and a decrease in neuronal density in CA1 and CA3 regions. Additionally, CHRE significantly increased the activities of antioxidant enzymes (SOD, CAT, GPx) and Nrf2 expression. This was coupled with significantly decreased MDA levels and active caspase-3 expression in the hippocampus of Aβ1-42-induced rats, which was similar to vitamin C exposure. Conclusions: Our findings suggested that CHRE ameliorated cognitive deficits and exhibited neuroprotective effects by reducing free radical damage and mitigating neuronal abnormality and neuronal death. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Optimizing Extraction, Evaluating Antioxidant Activity, and Analyzing Bioactive Compounds in Trikaysornmas Formula.

Author

Limsakul, Suphatson, Monthakantirat, Orawan, Chulikhit, Yaowared, Maneenet, Juthamart, Khamphukdee, Charinya, Chotritthirong, Yutthana, Phasomsap, Achiraya, Boonyarat, Chantana, Daodee, Supawadee, and Chan, Kim Wei

Subjects
REACTIVE oxygen species, BAEL (Tree), BIOACTIVE compounds, RADICAL cations, EAST Indian lotus
Abstract

The Trikaysornmas formula (TKM) represents a prevalent Thai traditional remedy utilized extensively in Thailand. Its traditional uses include appetite enhancement, functions as a nourishing tonic, and exhibits adaptogenic properties. Comprising Aegle marmelos fruit, Nelumbo nucifera stamen, and Jatropha multifida bark, this formula embodies the synergy among these three herbs. The objective of this study was to optimize the extraction method, determine the active compounds in the TKM, and evaluate its antioxidant activity. The optimization of the extraction method for this formula was studied using an experimental design. Phytochemical components such as total phenolics, total flavonoids, total carotenoids, and total alkaloids were assessed utilizing a colorimetric method. Antioxidant activities were assessed through DPPH free radical scavenging, ABTS radical cation decolorization, oxygen radical absorbance capacity, ferric reducing antioxidant power, metal chelating activity, and lipid peroxidation assay. For the analysis of active constituents in the formula, gallic acid, kaempferol‐3‐o‐glucoside, imperatorin, vitexin, and scopoletin, a validated reversed‐phase column high‐performance liquid chromatography (HPLC) method was developed. The total active contents including phenolic, flavonoid, carotenoid, and alkaloid compounds were found in the formula. The developed HPLC method exhibited reliable results in all validation parameters. TKM demonstrated antioxidant activity in the models used in this research. The findings from this study can serve as valuable tools for standardization and quality control measures. Additionally, they can contribute to maximizing the possibilities inherent in this traditional Thai formulation. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Effectiveness of Tri-Kaysorn-Mas Extract in Ameliorating Cognitive-like Behavior Deficits in Ovariectomized Mice via Activation of Multiple Mechanisms.

Author

Mading, Abdulwaris, Chotritthirong, Yutthana, Chulikhit, Yaowared, Daodee, Supawadee, Boonyarat, Chantana, Khamphukdee, Charinya, Sukketsiri, Wanida, Kwankhao, Pakakrong, Pitiporn, Supaporn, and Monthakantirat, Orawan

Subjects
SUPEROXIDE dismutase, BRAIN damage, POSTMENOPAUSE, HERBAL medicine, OVARIECTOMY
Abstract

Postmenopausal women have a higher probability of experiencing cognitive alterations compared to men, suggesting that the decline in female hormones may contribute to cognitive deterioration. Thailand traditionally uses Tri-Kaysorn-Mas (TKM), a blend of three medicinal herbs, as a tonic to stimulate appetite and relieve dyspepsia. Due to its antioxidant and anti-acetylcholinesterase activities, we investigated the effects of TKM (50 and 100 mg/kg/day, p.o., for 8 weeks) on cognitive deficits and their underlying causes in an ovariectomized (OVX) mouse model of menopause. OVX mice showed cognitive impairment in the Y-maze, novel object recognition task (NORT), and Morris water maze (MWM) behavioral tests, along with atrophic changes to the uterus, altered levels of serum 17β-estradiol, and down-regulated expression of estrogen receptors (ERα and ERβ). These behavioral effects were reversed by TKM. TKM decreased malondialdehyde (MDA) levels and mitigated oxidative stress in the brain by enhancing the activity of superoxide dismutase (SOD) and catalase (CAT) and by up-regulating the antioxidant-related gene Nrf2 while down-regulating Keap1. TKM also counteracted OVX-induced neurodegeneration by enhancing the expression of the neurogenesis-related genes BDNF and CREB. The results indicate that TKM extract alleviates oxidative brain damage and neurodegeneration while enhancing cognitive behavior in OVX mice, significantly improving cognitive deficiencies related to menopause/ovariectomy through multiple targets. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Effect of Diacetylcurcumin Manganese Complex on Rotenone-Induced Oxidative Stress, Mitochondria Dysfunction, and Inflammation in the SH-SY5Y Parkinson’s Disease Cell Model

Author

Pirunkaset, Ekanong, primary, Boonyarat, Chantana, additional, Maneenet, Juthamart, additional, Khamphukdee, Charinya, additional, Daodee, Supawadee, additional, Monthakantirat, Orawan, additional, Awale, Suresh, additional, Kijjoa, Anake, additional, and Chulikhit, Yaowared, additional

Published
2024
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14. Evaluation of the Impact of Alternanthera philoxeroides (Mart.) Griseb. Extract on Memory Impairment in D-Galactose-Induced Brain Aging in Mice through Its Effects on Antioxidant Enzymes, Neuroinflammation, and Telomere Shortening

Author

Aon-im, Possatorn, primary, Monthakantirat, Orawan, additional, Daodee, Supawadee, additional, Chulikhit, Yaowared, additional, Sriya, Nattapatsorn, additional, Boonyarat, Chantana, additional, Chumwangwapee, Thanut, additional, Khamphukdee, Charinya, additional, and Kijjoa, Anake, additional

Published
2024
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17. Approach of Supercritical Carbon Dioxide for the Extraction of Kleeb Bua Daeng Formula

Author

Ngamkhae, Nittaya, primary, Monthakantirat, Orawan, additional, Chulikhit, Yaowared, additional, Maneenet, Juthamart, additional, Khamphukdee, Charinya, additional, Chotritthirong, Yutthana, additional, Limsakul, Suphatson, additional, Boonyarat, Chantana, additional, Pitiporn, Supaporn, additional, Kwankhao, Pakakrong, additional, Kijjoa, Anake, additional, and Daodee, Supawadee, additional

Published
2023
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19. The Effect of Ethanol Extract from Mesua ferrea Linn Flower on Alzheimer’s Disease and Its Underlying Mechanism

Author

Plekratoke, Kusawadee, primary, Boonyarat, Chantana, additional, Monthakantirat, Orawan, additional, Nualkaew, Natsajee, additional, Wangboonskul, Jinda, additional, Awale, Suresh, additional, Chulikhit, Yaowared, additional, Daodee, Supawadee, additional, Khamphukdee, Charinya, additional, Chaiwiwatrakul, Suchada, additional, and Waiwut, Pornthip, additional

Published
2023
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22. Total Active Compounds and Mineral Contents in Wolffia globosa

Author

Monthakantirat, Orawan, primary, Chulikhit, Yaowared, additional, Maneenet, Juthamart, additional, Khamphukdee, Charinya, additional, Chotritthirong, Yutthana, additional, Limsakul, Suphatson, additional, Punya, Tanakorn, additional, Turapra, Buntarawan, additional, Boonyarat, Chantana, additional, and Daodee, Supawadee, additional

Published
2022
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25. Toxicity Profiles of Kleeb Bua Daeng Formula, a Traditional Thai Medicine, and Its Protective Effects on Memory Impairment in Animals

Author

Waiwut, Pornthip, primary, Kengkoom, Kanchana, additional, Pannangrong, Wanassanun, additional, Musigavong, Natdanai, additional, Chheng, Chantha, additional, Plekratoke, Kusawadee, additional, Taklomthong, Pitchayakarn, additional, Nillert, Nutchareeporn, additional, Pitiporn, Supaporn, additional, Kwankhao, Pakakrong, additional, Daodee, Supawadee, additional, Chulikhit, Yaowared, additional, Montakantirat, Orawan, additional, and Boonyarat, Chantana, additional

Published
2022
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26. Effect of Yakae-Prajamduen-Jamod Traditional Thai Remedy on Cognitive Impairment in an Ovariectomized Mouse Model and Its Mechanism of Action

Author

Daodee, Supawadee, primary, Monthakantirat, Orawan, additional, Tantipongpiradet, Ariyawan, additional, Maneenet, Juthamart, additional, Chotritthirong, Yutthana, additional, Boonyarat, Chantana, additional, Khamphukdee, Charinya, additional, Kwankhao, Pakakrong, additional, Pitiporn, Supaporn, additional, Awale, Suresh, additional, Matsumoto, Kinzo, additional, and Chulikhit, Yaowared, additional

Published
2022
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30. Effects of the Bark Resin Extract of Garcinia nigrolineata on Chronic Stress-Induced Memory Deficit in Mice Model and the In Vitro Monoamine Oxidases and β-Amyloid Aggregation Inhibitory Activities of Its Prenylated Xanthone Constituents

Author

Khamphukdee, Charinya, primary, Turkmani, Ibrahim, additional, Chotritthirong, Yutthana, additional, Chulikhit, Yaowared, additional, Boonyarat, Chantana, additional, Sekeroglu, Nazim, additional, Silva, Artur M. S., additional, Monthakantirat, Orawan, additional, and Kijjoa, Anake, additional

Published
2022
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42. Antidementia Effects of Alternanthera philoxeroides in Ovariectomized Mice Supported by NMR-Based Metabolomic Analysis

Author

Khamphukdee, Charinya, primary, Monthakantirat, Orawan, additional, Chulikhit, Yaowared, additional, Boonyarat, Chantana, additional, Daodee, Supawadee, additional, Aon-im, Possatorn, additional, Maneenet, Juthamart, additional, Chotritthirong, Yutthana, additional, Luecha, Prathan, additional, Sekeroglu, Nazim, additional, and Kijjoa, Anake, additional

Published
2021
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45. Clausena Harmandiana root extract attenuated cognitive impairments via reducing amyloid accumulation and neuroinflammation in Aβ1-42-induced rats.

Author

Nillert, Nutchareeporn, Boonyarat, Chantana, Welbat, Jariya Umka, Bunreungthong, Komsun, Puthongking, Ploenthip, and Pannangrong, Wanassanun

Subjects
COGNITION disorders, AMYLOID, PROTEINS, CYCLOOXYGENASE 2, RECOGNITION (Psychology), MEMORY, BIOMARKERS, INTERLEUKINS, MEDICINAL plants, INJECTIONS, THIOPENTAL, HIPPOCAMPUS (Brain), ANTI-inflammatory agents, ANIMAL experimentation, NONSTEROIDAL anti-inflammatory agents, ORAL drug administration, PLANT roots, NEUROINFLAMMATION, RATS, COMPARATIVE studies, NEUROPROTECTIVE agents, TUMOR necrosis factors, PLANT extracts, STATISTICAL sampling, CELLULOSE, INFLAMMATORY mediators, PHYSIOLOGIC salines, CEREBRAL cortex, PHARMACODYNAMICS
Abstract

Background: Alzheimer's disease (AD) pathogenesis is associated with amyloid-β (Aβ)-induced neuroinflammation. In AD, the activation of microglia caused by Aβ accumulation is followed by the synthesis and release of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNFα), and ultimately leads to cognitive impairments. Clausena harmandiana (CH) is a medicinal plant in the Rutaceae family and has been used in folk medicine to relieve illnesses such as stomachache and headache, and as a health tonic. Interestingly, CH root extract (CHRE) has several anti-inflammatory and other pharmacological activities, but there are no studies in AD-like animal models. Objectives: This study aims to evaluate the effects of CHRE on cognitive impairments, increased Aβ1–42 protein levels, and neuroinflammation in Aβ1–42-induced rats. Methods: Forty-eight adult male Sprague-Dawley rats (250–300 g) were randomly divided into 6 groups (n = 8) of the sham control, V + Aβ, CB + Aβ CHRE125 + Aβ, CHRE250 + Aβ, and CHRE500 + Aβ. Sodium carboxymethylcellulose, Celebrex (10 mg/kg BW) and CHRE (125, 250, and 500 mg/kg BW) were given orally or without any treatment for 35 days. On day 21, aggregated Aβ1–42 at a concentration of 1 μg/μl were injected into both lateral ventricles (1 μl/side) of all treated rats, while sterilized normal saline were injected to untreated rats. Ten days later, the novel object recognition test was performed to assess their recognition memory. At the end of the test period, an overdose of thiopental sodium (120 mg/kg BW) and transcardial perfusion with 0.9% normal saline solution were used to euthanize all rats. Then Aβ1–42 protein levels and the expression of inflammatory markers (CD11b-positive microglia, IL-1β, and TNFα) were investigated in the cerebral cortex and hippocampus. Results: Pretreatment with CHRE at all doses could attenuate short- and long-term impairments in recognition memory. Additionally, CHRE also inhibited the increase of Aβ1–42 protein levels and the expression of inflammatory markers in both brain regions as well as receiving Celebrex. Conclusions: This suggests that preventive treatment of CHRE might be a potential therapy against cognitive impairments via reducing Aβ1–42 protein levels and neuroinflammation caused by Aβ1–42. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice

Author

Maneenet, Juthamart, primary, Daodee, Supawadee, additional, Monthakantirat, Orawan, additional, Boonyarat, Chantana, additional, Khamphukdee, Charinya, additional, Kwankhao, Pakakrong, additional, Pitiporn, Supaporn, additional, Awale, Suresh, additional, Chulikhit, Yaowared, additional, and Kijjoa, Anake, additional

Published
2019
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49. In Vitro and In Vivo effect of Chia oil (Salvia hispanica L.) on Haplorchis taichui

Author

Songsri, Jiraporn, primary, Ketthaisong, Danupol, additional, Boonmars, Thidarut, additional, Boueroy, Parichart, additional, Laummaunwai, Porntip, additional, Vaeteewoottacharn, Kulthida, additional, Rattanasuwan, Panaratana, additional, Boonyarat, Chantana, additional, Lomthaisong, Khomsorn, additional, Tangwongchai, Ratchada, additional, and Borlace, Glenn N, additional

Published
2019
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50. Benzylisoquinoline alkaloids from Nelumbo nuciferaGaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line

Author

Maneenet, Juthamart, Omar, Ashraf M., Sun, Sijia, Kim, Min Jo, Daodee, Supawadee, Monthakantirat, Orawon, Boonyarat, Chantana, Chulikhit, Yaowared, and Awale, Suresh

Abstract

Ethanolic extract of Nelumbo nuciferapetals showed preferential cytotoxic activity against HeLa human cervical cancer cell line with a PC50value of 10.4 μg/mL. This active extract was subjected to a phytochemical investigation study which led to the isolation of nine benzylisoquinoline alkaloids (1–9). The isolated compounds exhibited potent antiausterity activities. Moreover, under nutrient-deprived conditions, (−)-lirinidine (8) induced remarkable alterations in HeLa cell morphology including cell shrinkage and plasma blebbing leading to total cell death within 10 h. Mechanistically, 8was found to inhibit Akt/mTOR signaling pathway. It also induced apoptosis by promoting caspase-3 activation and inhibiting Bcl-2 expression. Therefore, benzylisoquinoline alkaloids skeleton can be considered as a promising scaffold for the anticancer drug development against cervical cancer.

Published
2021
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