432 results on '"Boone B"'
Search Results
2. Calcineurin Inhibitors
- Author
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Van Geel, N., Boone, B., Mollet, I., Lambert, J., Picardo, Mauro, editor, and Taïeb, Alain, editor
- Published
- 2010
- Full Text
- View/download PDF
3. The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer
- Author
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Boone, B A, Orlichenko, L, Schapiro, N E, Loughran, P, Gianfrate, G C, Ellis, J T, Singhi, A D, Kang, R, Tang, D, Lotze, M T, and Zeh, H J
- Published
- 2015
- Full Text
- View/download PDF
4. Mohs micrographic surgery for basal cell carcinoma: evaluation of the indication criteria and predictive factors for extensive subclinical spread
- Author
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Hoorens, I., Batteauw, A., Van Maele, G., Lapiere, K., Boone, B., and Ongenae, K.
- Published
- 2016
- Full Text
- View/download PDF
5. Cessation of spread as a treatment objective in vitiligo: perception from the patientsʼ point of view
- Author
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van Geel, N., Desmedt, V., De Schepper, S., Boone, B., Lapeere, H., and Speeckaert, R.
- Published
- 2016
- Full Text
- View/download PDF
6. Silver Soled State Energy Storage Devices
- Author
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Owens, Boone B., Scrosati, B., editor, Magistris, A., editor, Mari, C. M., editor, and Mariotto, G., editor
- Published
- 1993
- Full Text
- View/download PDF
7. Electroporation-mediated delivery of a naked DNA plasmid expressing VEGF to the porcine heart enhances protein expression
- Author
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Marshall, Jr, W G, Boone, B A, Burgos, J D, Gografe, S I, Baldwin, M K, Danielson, M L, Larson, M J, Caretto, D R, Cruz, Y, Ferraro, B, Heller, L C, Ugen, K E, Jaroszeski, M J, and Heller, R
- Published
- 2010
- Full Text
- View/download PDF
8. Classification of segmental vitiligo on the trunk*
- Author
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van Geel, N., Bosma, S., Boone, B., and Speeckaert, R.
- Published
- 2014
- Full Text
- View/download PDF
9. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
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Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard M, Abudu Y, Acevedo-Arozena A, Adamopoulos I, Adeli K, Adolph T, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal B, Agnello M, Agostinis P, Agrewala J, Agrotis A, Aguilar P, Ahmad S, Ahmed Z, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar H, Al-Abd A, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali M, Alberti S, Alcocer-Gomez E, Alessandri C, Ali M, Al-Bari M, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso G, Altan-Bonnet N, Altieri D, Alves S, da Costa C, Alzaharna M, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer A, Ammanathan V, An Z, Andersen S, Andrabi S, Andrade-Silva M, Andres A, Angelini S, Ann D, Anozie U, Ansari M, Antas P, Antebi A, Anton Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araujo W, Araya J, Arden C, Arevalo M, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa A, Armstrong-James D, Arnaune-Pelloquin L, Aroca A, Arroyo D, Arsov I, Artero R, Asaro D, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov A, Au A, Auberger P, Auner H, Aurelian L, Autelli R, Avagliano L, Avalos Y, Aveic S, Aveleira C, AvinWittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer J, Backues S, Bae D, Bae O, Bae S, Baehrecke E, Baek A, Baek S, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari C, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Bao Y, Baptista M, Baracca A, Barbati C, Bargiela A, Barila D, Barlow P, Barmada S, Barreiro E, Barreto G, Bartek J, Bartel B, Bartolome A, Barve G, Basagoudanavar S, Bassham D, Jr R, Basu A, Batoko H, Batten I, Baulieu E, Baumgarner B, Bayry J, Beale R, Beau I, Beaumatin F, Bechara L, Beck G, Beers M, Begun J, Behrends C, Behrens G, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touze N, Bellarosa C, Belleudi F, Perez M, Bello-Morales R, Beltran J, Beltran S, Benbrook D, Bendorius M, Benitez B, Benito-Cuesta I, Bensalem J, Berchtold M, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli C, Besteiro S, Betin V, Beyaert R, Bezbradica J, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan M, Bhutia S, Bi L, Bi X, Biden T, Bijian K, Billes V, Binart N, Bincoletto C, Birgisdottir A, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum J, Boada-Romero E, Boban M, BoeszeBattaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam S, Bonfili L, Bonifacino J, Boone B, Bootman M, Bordi M, Borner C, Bornhauser B, Borthakur G, Bosch J, Bose S, Botana L, Botas J, Boulanger C, Boulton M, Bourdenx M, Bourgeois B, Bourke N, Bousquet G, Boya P, Bozhkov P, Bozi L, Bozkurt T, Brackney D, Brandts C, Braun R, Braus G, Bravo-Sagua R, Bravo-San Pedro J, Brest P, Bringer M, Briones-Herrera A, Broaddus V, Brodersen P, Alvarez E, Brodsky J, Brody S, Bronson P, Bronstein J, Brown C, Brown R, Brum P, Brumell J, Brunetti-Pierri N, Bruno D, Bryson-Richardson R, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina L, Buraschi S, Buch S, Buchan J, Buckingham E, Budak H, Budini M, Bultynck G, Burada F, Burgoyne J, Buron M, Bustos V, Buttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairo M, Calbet J, Caldwell G, Caldwell K, Call J, Calvani R, Calvo A, Barrera M, Camara N, Camonis J, Camougrand N, Campanella M, Campbell E, Campbell-Valois F, Campello S, Campesi I, Campos J, Camuzard O, Cancino J, de Almeida D, Canesi L, Caniggia I, Canonico B, Canti C, Cao B, Caraglia M, Carames B, Carchman E, Cardenal-Munoz E, Cardenas C, Cardenas L, Cardoso S, Carew J, Carle G, Carleton G, Carloni S, Carmona-Gutierrez D, Carneiro L, Carnevali O, Carosi J, Carra S, Carrier A, Carrier L, Carroll B, Carter A, Carvalho A, Casanova M, Casas C, Casas J, Cassioli C, Castillo E, Castillo K, Castillo-Lluva S, Castoldi F, Castori M, Castro A, Castro-Caldas M, Castro-Hernandez J, Castro-Obregon S, Catz S, Cavadas C, Cavaliere F, Cavallini G, Cavinato M, Cayuela M, Rica P, Cecarini V, Cecconi F, Cechowska-Pasko M, Cenci S, Ceperuelo-Mallafre V, Cerqueira J, Cerutti J, Cervia D, Cetintas V, Cetrullo S, Chae H, Chagin A, Chai C, Chakrabarti G, Chakrabarti O, Chakraborty T, Chami M, Chamilos G, Chan D, Chan E, Chan H, Chan M, Chan Y, Chandra P, Chang C, Chang H, Chang K, Chao J, Chapman T, Charlet-Berguerand N, Chatterjee S, Chaube S, Chaudhary A, Chauhan S, Chaum E, Checler F, Cheetham M, Chen C, Chen G, Chen J, Chen L, Chen M, Chen N, Chen Q, Chen R, Chen S, Chen W, Chen X, Chen Y, Chen Z, Cheng H, Cheng J, Cheng S, Cheng W, Cheng X, Cheng Y, Cheng Z, Cheong H, Cheong J, Chernyak B, Cherry S, Cheung C, Cheung K, Chevet E, Chi R, Chiang A, Chiaradonna F, Chiarelli R, Chiariello M, Chica N, Chiocca S, Chiong M, Chiou S, Chiramel A, Chiurchiu V, Cho D, Choe S, Choi A, Choi M, Choudhury K, Chow N, Chu C, Chua J, Chung H, Chung K, Chung S, Chung Y, Cianfanelli V, Ciechomska I, Cifuentes M, Cinque L, Cirak S, Cirone M, Clague M, Clarke R, Clementi E, Coccia E, Codogno P, Cohen E, Cohen M, Colasanti T, Colasuonno F, Colbert R, Colell A, Coll N, Collins M, Colombo M, Colon-Ramos D, Combaret L, Comincini S, Cominetti M, Consiglio A, Conte A, Conti F, Contu V, Cookson M, Coombs K, Coppens I, Corasaniti M, Corkery D, Cordes N, Cortese K, Costa M, Costantino S, Costelli P, Coto-Montes A, Crack P, Crespo J, Criollo A, Crippa V, Cristofani R, Csizmadia T, Cuadrado A, Cui B, Cui J, Cui Y, Culetto E, Cumino A, Cybulsky A, Czaja M, Czuczwar S, D'Adamo S, D'Amelio M, D'Arcangelo D, D'Lugos A, D'Orazi G, da Silva J, Dafsari H, Dagda R, Dagdas Y, Daglia M, Dai X, Dai Y, Dal Col J, Dalhaimer P, Dalla Valle L, Dallenga T, Dalmasso G, Damme M, Dando I, Dantuma N, Darling A, Das H, Dasarathy S, Dasari S, Dash S, Daumke O, Dauphinee A, Davies J, Davila V, Davis R, Davis T, Naidu S, De Amicis F, De Bosscher K, De Felice F, De Franceschi L, De Leonibus C, Barbosa M, De Meyer G, De Milito A, De Nunzio C, De Palma C, De Santi M, De Virgilio C, De Zio D, Debnath J, DeBosch B, Decuypere J, Deehan M, Deflorian G, DeGregori J, Dehay B, Del Rio G, Delaney J, Delbridge L, Delorme-Axford E, Delpino M, Demarchi F, Dembitz V, Demers N, Deng H, Deng Z, Dengjel J, Dent P, Denton D, DePamphilis M, Der C, Deretic V, Descoteaux A, Devis L, Devkota S, Devuyst O, Dewson G, Dharmasivam M, Dhiman R, di Bernardo D, Di Cristina M, Di Domenico F, Di Fazio P, Di Fonzo A, Di Guardo G, Di Guglielmo G, Di Leo L, Di Malta C, Di Nardo A, Di Rienzo M, Di Sano F, Diallinas G, Diao J, Diaz-Araya G, Diaz-Laviada I, Dickinson J, Diederich M, Dieude M, Dikic I, Ding S, Ding W, Dini L, Dinic M, Dinkova-Kostova A, Dionne M, Distler J, Diwan A, Dixon I, Djavaheri-Mergny M, Dobrinski I, Dobrovinskaya O, Dobrowolski R, Dobson R, Emre S, Donadelli M, Dong B, Dong X, Dong Z, Ii G, Dotsch V, Dou H, Dou J, Dowaidar M, Dridi S, Drucker L, Du A, Du C, Du G, Du H, Du L, du Toit A, Duan S, Duan X, Duarte S, Dubrovska A, Dunlop E, Dupont N, Duran R, Dwarakanath B, Dyshlovoy S, Ebrahimi-Fakhari D, Eckhart L, Edelstein C, Efferth T, Eftekharpour E, Eichinger L, Eid N, Eisenberg T, Eissa N, Eissa S, Ejarque M, El Andaloussi A, El-Hage N, El-Naggar S, Eleuteri A, El-Shafey E, Elgendy M, Eliopoulos A, Elizalde M, Elks P, Elsasser H, Elsherbiny E, Emerling B, Emre N, Eng C, Engedal N, Engelbrecht A, Engelsen A, Enserink J, Escalante R, Esclatine A, Escobar-Henriques M, Eskelinen E, Espert L, Eusebio M, Fabrias G, Fabrizi C, Facchiano A, Facchiano F, Fadeel B, Fader C, Faesen A, Fairlie W, Falco A, Falkenburger B, Fan D, Fan J, Fan Y, Fang E, Fang Y, Fanto M, Farfel-Becker T, Faure M, Fazeli G, Fedele A, Feldman A, Feng D, Feng J, Feng L, Feng Y, Feng W, Araujo T, Ferguson T, Fernandez-Checa J, FernandezVeledo S, Fernie A, Ferrante A, Ferraresi A, Ferrari M, Ferreira J, Ferro-Novick S, Figueras A, Filadi R, Filigheddu N, FilippiChiela E, Filomeni G, Fimia G, Fineschi V, Finetti F, Finkbeiner S, Fisher E, Fisher P, Flamigni F, Fliesler S, Flo T, Florance I, Florey O, Florio T, Fodor E, Follo C, Fon E, Forlino A, Fornai F, Fortini P, Fracassi A, Fraldi A, Franco B, Franco R, Franconi F, Frankel L, Friedman S, Frohlich L, Fruhbeck G, Fuentes J, Fujiki Y, Fujita N, Fujiwara Y, Fukuda M, Fulda S, Furic L, Furuya N, Fusco C, Gack M, Gaffke L, Galadari S, Galasso A, Galindo M, Kankanamalage S, Galluzzi L, Galy V, Gammoh N, Gan B, Ganley I, Gao F, Gao H, Gao M, Gao P, Gao S, Gao W, Gao X, Garcera A, Garcia M, Garcia V, Garcia-Del Portillo F, Garcia-Escudero V, GarciaGarcia A, Garcia-Macia M, Garcia-Moreno D, Garcia-Ruiz C, Garcia-Sanz P, Garg A, Gargini R, Garofalo T, Garry R, Gassen N, Gatica D, Ge L, Ge W, Geiss-Friedlander R, Gelfi C, Genschik P, Gentle I, Gerbino V, Gerhardt C, Germain K, Germain M, Gewirtz D, Afshar E, Ghavami S, Ghigo A, Ghosh M, Giamas G, Giampietri C, Giatromanolaki A, Gibson G, Gibson S, Ginet V, Giniger E, Giorgi C, Girao H, Girardin S, Giridharan M, Giuliano S, Giulivi C, Giuriato S, Giustiniani J, Gluschko A, Goder V, Goginashvili A, Golab J, Goldstone D, Golebiewska A, Gomes L, Gomez R, Gomez-Sanchez R, Gomez-Puerto M, Gomez-Sintes R, Gong Q, Goni F, Gonzalez-Gallego J, Gonzalez-Hernandez T, Gonzalez-Polo R, Gonzalez-Reyes J, Gonzalez-Rodriguez P, Goping I, Gorbatyuk M, Gorbunov N, Gorojod R, Gorski S, Goruppi S, Gotor C, Gottlieb R, Gozes I, Gozuacik D, Graef M, Graler M, Granatiero V, Grasso D, Gray J, Green D, Greenhough A, Gregory S, Griffin E, Grinstaff M, Gros F, Grose C, Gross A, Gruber F, Grumati P, Grune T, Gu X, Guan J, Guardia C, Guda K, Guerra F, Guerri C, Guha P, Guillen C, Gujar S, Gukovskaya A, Gukovsky I, Gunst J, Gunther A, Guntur A, Guo C, Guo H, Guo L, Guo M, Gupta P, Fernandez A, Gupta S, Gupta V, Gustafsson A, Gutterman D, Ranjitha H, Haapasalo A, Haber J, Hadano S, Hafren A, Haidar M, Hall B, Hallden G, Hamacher-Brady A, Hamann A, Hamasaki M, Han W, Hansen M, Hanson P, Hao Z, Harada M, Harhaji-Trajkovic L, Hariharan N, Haroon N, Harris J, Hasegawa T, Nagoor N, Haspel J, Haucke V, Hawkins W, Hay B, Haynes C, Hayrabedyan S, Hays T, He C, He Q, He R, He Y, Heakal Y, Heberle A, Hejtmancik J, Helgason G, Henkel V, Herb M, Hergovich A, Herman-Antosiewicz A, Hernandez A, Hernandez C, Hernandez-Diaz S, Hernandez-Gea V, Herpin A, Herreros J, Hervas J, Hesselson D, Hetz C, Heussler V, Higuchi Y, Hilfiker S, Hill J, Hlavacek W, Ho E, Ho I, Ho P, Ho S, Ho W, Hobbs G, Hochstrasser M, Hoet P, Hofius D, Hofman P, Hohn A, Holmberg C, Hombrebueno J, Hong C, Hong Y, Hooper L, Hoppe T, Horos R, Hoshida Y, Hsin I, Hsu H, Hu B, Hu D, Hu L, Hu M, Hu R, Hu W, Hu Y, Hu Z, Hua F, Hua J, Hua Y, Huan C, Huang C, Huang H, Huang K, Huang M, Huang R, Huang S, Huang T, Huang X, Huang Y, Huber T, Hubert V, Hubner C, Hughes S, Hughes W, Humbert M, Hummer G, Hurley J, Hussain S, Hussey P, Hutabarat M, Hwang H, Hwang S, Ieni A, Ikeda F, Imagawa Y, Imai Y, Imbriano C, Imoto M, Inman D, Inoki K, Iovanna J, Iozzo R, Ippolito G, Irazoqui J, Iribarren P, Ishaq M, Ishikawa M, Ishimwe N, Isidoro C, Ismail N, Issazadeh-Navikas S, Itakura E, Ito D, Ivankovic D, Ivanova S, Iyer A, Izquierdo J, Izumi M, Jaattela M, Jabir M, Jackson W, Jacobo-Herrera N, Jacomin A, Jacquin E, Jadiya P, Jaeschke H, Jagannath C, Jakobi A, Jakobsson J, Janji B, JansenDurr P, Jansson P, Jantsch J, Jassey A, Jean S, JeltschDavid H, Jendelova P, Jenny A, Jensen T, Jessen N, Jewell J, Ji J, Jia L, Jia R, Jiang L, Jiang Q, Jiang R, Jiang T, Jiang X, Jiang Y, Jimenez-Sanchez M, Jin E, Jin F, Jin H, Jin L, Jin M, Jin S, Jo E, Joffre C, Johansen T, Johnson G, Johnston S, Jokitalo E, Jolly M, Joosten L, Jordan J, Joseph B, Ju D, Ju J, Juarez E, Judith D, Juhasz G, Jun Y, Jung C, Jung S, Jung Y, Jungbluth H, Jungverdorben J, Just S, Kaarniranta K, Kaasik A, Kabuta T, Kaganovich D, Kahana A, Kain R, Kajimura S, Kalamvoki M, Kalia M, Kalinowski D, Kaludercic N, Kalvari I, Kaminska J, Kaminskyy V, Kanamori H, Kanasaki K, Kang C, Kang R, Kang S, Kaniyappan S, Kanki T, Kanneganti T, Kanthasamy A, Kantorow M, Kapuy O, Karamouzis M, Karim M, Karmakar P, Katare R, Kato M, Kaufmann S, Kauppinen A, Kaushal G, Kaushik S, Kawasaki K, Kazan K, Ke P, Keating D, Keber U, Kehrl J, Keller K, Keller C, Kemper J, Kenific C, Kepp O, Kermorgant S, Kern A, Ketteler R, Keulers T, Khalfin B, Khalil H, Khambu B, Khan S, Khandelwal V, Khandia R, Kho W, Khobrekar N, Khuansuwan S, Khundadze M, Killackey S, Kim D, Kim E, Kim H, Kim J, Kim K, Kim P, Kim S, Kimball S, Kimchi A, Kimmelman A, Kimura T, King M, Kinghorn K, Kinsey C, Kirkin V, Kirshenbaum L, Kiselev S, Kishi S, Kitamoto K, Kitaoka Y, Kitazato K, Kitsis R, Kittler J, Kjaerulff O, Klein P, Klopstock T, Klucken J, Knovelsrud H, Knorr R, Ko B, Ko F, Ko J, Kobayashi H, Kobayashi S, Koch I, Koch J, Koenig U, Kogel D, Koh Y, Koike M, Kohlwein S, Kocaturk N, Komatsu M, Konig J, Kono T, Kopp B, Korcsmaros T, Korkmaz G, Korolchuk V, Korsnes M, Koskela A, Kota J, Kotake Y, Kotler M, Kou Y, Koukourakis M, Koustas E, Kovacs A, Kovacs T, Koya D, Kozako T, Kraft C, Krainc D, Kramer H, Krasnodembskaya A, Kretz-Remy C, Kroemer G, Ktistakis N, Kuchitsu K, Kuenen S, Kuerschner L, Kukar T, Kumar A, Kumar D, Kumar S, Kume S, Kumsta C, Kundu C, Kundu M, Kunnumakkara A, Kurgan L, Kutateladze T, Kutlu O, Kwak S, Kwon H, Kwon T, Kwon Y, Kyrmizi I, La Spada A, Labonte P, Ladoire S, Laface I, Lafont F, Lagace D, Lahiri V, Lai Z, Laird A, Lakkaraju A, Lamark T, Lan S, Landajuela A, Lane D, Lane J, Lang C, Lange C, Langer R, Lapaquette P, Laporte J, LaRusso N, Lastres-Becker I, Lau W, Laurie G, Lavandero S, Law B, Law H, Layfield R, Le W, Le Stunff H, Leary A, Lebrun J, Leck L, Leduc-Gaudet J, Lee C, Lee D, Lee E, Lee G, Lee H, Lee J, Lee M, Lee S, Lee W, Lee Y, Lefebvre C, Legouis R, Lei Y, Leikin S, Leitinger G, Lemus L, Leng S, Lenoir O, Lenz G, Lenz H, Lenzi P, Leon Y, Leopoldino A, Leschczyk C, Leskela S, Letellier E, Leung C, Leung P, Leventhal J, Levine B, Lewis P, Ley K, Li B, Li D, Li J, Li K, Li L, Li M, Li P, Li Q, Li S, Li T, Li W, Li X, Li Y, Li Z, Lian J, Liang C, Liang Q, Liang W, Liang Y, Liao G, Liao L, Liao M, Liao Y, Librizzi M, Lie P, Lilly M, Lim H, Lima T, Limana F, Lin C, Lin D, Lin F, Lin J, Lin K, Lin L, Lin P, Lin Q, Lin S, Lin W, Lin X, Lin Y, Linden R, Lindner P, Ling S, Lingor P, Linnemann A, Liou Y, Lipinski M, Lipovsek S, Lira V, Lisiak N, Liton P, Liu C, Liu F, Liu H, Liu J, Liu L, Liu M, Liu Q, Liu W, Liu X, Liu Y, Livingston J, Lizard G, Lizcano J, Ljubojevic-Holzer S, LLeonart M, Llobet-Navas D, Llorente A, Lo C, Lobato-Marquez D, Long Q, Long Y, Loos B, Loos J, Lopez M, Lopez-Domenech G, Lopez-Guerrero J, Lopez-Jimenez A, Lopez-Valero I, Lorenowicz M, Lorente M, Lorincz P, Lossi L, Lotersztajn S, Lovat P, Lovell J, Lovy A, Lu G, Lu H, Lu J, Lu M, Lu S, Luciani A, Lucocq J, Ludovico P, Luftig M, Luhr M, Luis-Ravelo D, Lum J, Luna-Dulcey L, Lund A, Lund V, Lunemann J, Luningschror P, Luo 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flux ,macroautophagy ,phagophore ,stress ,vacuole ,Autophagosome ,LC3 ,lysosome ,neurodegeneration ,cancer - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
10. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith C, Stallings, Christina L, and Tong, Chun-Kit
- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
11. LBA-1 The Phase III Study: Targeted intra-arterial gemcitabine vs. continuation of IV gemcitabine plus nab-paclitaxel following induction with sequential IV gemcitabine plus nab-paclitaxel and radiotherapy for locally advanced pancreatic cancer (TIGeR-PaC)
- Author
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Pishvaian, M., Lopez, C., Zervos, E., Hatoum, H., Berg, D., Ucar, A., Boone, B., Johnson, T., Zureikat, A., Kenneth, M., Chung, K., Gandhi, R., Nazemzadeh, R., Parikh, N., Novelli, P., Kouri, B., Laing, C., Bates, S., Agah, R., and Goodman, K.
- Published
- 2023
- Full Text
- View/download PDF
12. The Effect of CD8+ Tumor-Infiltrating Lymphocytes on Sentinel Lymph Node Immune Status: FC-049
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Chevolet, I., Speeckaert, R., Boone, B., Van Geel, N., Van Gele, M., Haspeslagh, M., and Brochez, L.
- Published
- 2013
13. Use of a perfused cadaver for training of robotic pancreaticoduodenectomy allows for realistic tissue dissection and management of intra-operative bleeding
- Author
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Harris, B., primary, Rao, P., additional, Schmidt, C., additional, Boone, B., additional, and Grabo, D., additional
- Published
- 2021
- Full Text
- View/download PDF
14. The implementation of a new robotic hepatopancreatobiliary practice: Lessons learned
- Author
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Niemann, B., Kenney, C., Schmidt, C., Marsh, J., and Boone, B.
- Published
- 2023
- Full Text
- View/download PDF
15. Processing and Performance of V2O5 Xerogel, Aerogel, and Aerogellike Materials as Lithium Intercalation Hosts
- Author
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Manhart, Leland H., Xu, Jun John, Coustier, Fabrice, Passerini, Stefano, Owens, Boone B., and Smyrl, William H.
- Published
- 1998
- Full Text
- View/download PDF
16. Processing and Properties of Amorphous Manganese Dioxide Formed by Sol-Gel Procedures
- Author
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Xu, Jun John, Passerini, Stefano, Owens, Boone B., and Smyrl, William H.
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- 1998
- Full Text
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17. Monitoring Spacecraft Telemetry Via Optical or RF Link
- Author
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Fielhauer, K. B and Boone, B. G
- Subjects
Man/System Technology And Life Support - Abstract
A patent disclosure document discusses a photonic method for connecting a spacecraft with a launch vehicle upper-stage telemetry system as a means for monitoring a spacecraft fs health and status during and right after separation and deployment. This method also provides an efficient opto-coupled capability for prelaunch built-in-test (BIT) on the ground to enable more efficient and timely integration, preflight checkout, and a means to obviate any local EMI (electromagnetic interference) during integration and test. Additional utility can be envisioned for BIT on other platforms, such as the International Space Station (ISS). The photonic telemetry system implements an optical free-space link with a divergent laser transmitter beam spoiled over a significant cone angle to accommodate changes in spacecraft position without having to angle track it during deployment. Since the spacecraft may lose attitude control and tumble during deployment, the transmitted laser beam interrogates any one of several low-profile meso-scale retro-reflective spatial light modulators (SLMs) deployed over the surface of the spacecraft. The return signal beam, modulated by the SLMs, contains health, status, and attitude information received back at the launch vehicle. Very compact low-power opto-coupler technology already exists for the received signal (requiring relatively low bandwidths, e.g., .200 kbps) to enable transfer to a forward pass RF relay from the launch vehicle to TDRSS (Tracking and Data Relay Satellite System) or another recipient. The link would be active during separation and post-separation to monitor spacecraft health, status, attitude, or other data inventories until attitude recovery and ground control can be re-established. An optical link would not interfere with the existing upper stage telemetry and beacon systems, thus meeting launch vehicle EMI environmental constraints.
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- 2011
18. Electrochemistry of S adlayers at underpotentially deposited Cd on Au(111): implications for the electrosynthesis of high-quality CdS thin films
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Gichuhi, Anthony, Boone, B. Edward, Demir, Umit, and Shannon, Curtis
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Thin films -- Research ,Electrochemistry -- Research ,Epitaxy -- Research ,Chemicals, plastics and rubber industries - Abstract
A study was conducted to analyze thin CdS films prepared by electrochemical atomic layer epitaxy to examine the effects of the order of deposition on film quality. Electrochemical, scanning probe microscopy and Raman spectroscopy were used to carry out the study. The electrochemistry studies were performed in a single-compartment, three-electrode Teflon cells. Results indicated that the order of deposition supports a critical role in determining the atomic level structure of underpotential deposition overlays and the long range order of films.
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- 1998
19. Ionic conductivity of a poly(vinylpyridinium)/silver iodide solid polymer electrolyte system
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Pappenfus, Ted M., Henderson, Wesley A., Owens, Boone B., Mann, Kent R., and Smyrl, William H.
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- 2004
- Full Text
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20. High-Conductivity Solid Electrolytes: MAg$_{4}$I$_{5}$
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Owens, Boone B. and Argue, Gary R.
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- 1967
21. New Polymer Electrolyte Cell Systems
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Smyrl, William H, Owens, Boone B, Mann, Kent, Pappenfus, T, and Henderson, W
- Subjects
Composite Materials - Abstract
PAPERS PUBLISHED: 1. Pappenfus, Ted M.; Henderson, Wesley A.; Owens, Boone B.; Mann, Kent R.; Smyrl, William H. Complexes of Lithium Imide Salts with Tetraglyme and Their Polyelectrolyte Composite Materials. Journal of the Electrochemical Society (2004), 15 1 (2), A209-A2 15. 2. Pappenfus, Ted M.; Henderson, Wesley A.; Owens, Boone B.; Mann, Kent R.; Smyrl, William H. Ionic-liquidlpolymer electrolyte composite materials for electrochemical device applications. Polymeric Materials Science and Engineering (2003), 88 302. 3. Pappenfus, Ted R.; Henderson, Wesley A.; Owens, Boone B.; Mann, Kent R.; and Smyrl, William H. Ionic Conductivity of a poly(vinylpyridinium)/Silver Iodide Solid Polymer Electrolyte System. Solid State Ionics (in press 2004). 4. Pappenfus Ted M.; Mann, Kent R; Smyrl, William H. Polyelectrolyte Composite Materials with LiPFs and Tetraglyme. Electrochemical and Solid State Letters, (2004), 7(8), A254.
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- 2004
22. P-43 Correlation of mesothelin expression with recurrence in colorectal cancer (CRC) patients
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Malla, M., Fuqua, J., Olevian, D., Avalon, J., Wakefield, C., J. Karakiozis, Patel, B., Boone, B., Schmidt, C., Wen, S., Agazie, Y., Hazelhurst, L., and Goldberg, R.
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- 2022
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23. Neoadjuvant folfirinox in patients with (borderline) resectable pancreatic cancer: A systematic review and patient-level meta-analysis
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Buettner, S., primary, Janssen, Q., additional, Suker, M., additional, Beumer, B., additional, Addeo, P., additional, Bachellier, P., additional, Bahary, N., additional, Bekaii-Saab, T., additional, Bali, M., additional, Besselink, M., additional, Boone, B., additional, Chau, I., additional, Clarke, S., additional, Dillhoff, M., additional, El-Rayes, B., additional, Frakes, J., additional, Grose, D., additional, Hosein, P., additional, Jamieson, N., additional, Javed, A., additional, Khan, K., additional, Kim, K., additional, Kim, S., additional, Ko, A., additional, Lacy, J., additional, Margonis, G., additional, McCarter, M., additional, McKay, C., additional, Mellon, E., additional, and Moorcraft, S., additional
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- 2020
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24. Ionic mobilities in selected fused salt systems
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Boone B. Owens and Frederick R. Duke
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chemistry.chemical_classification ,Electrolysis ,Inorganic chemistry ,Analytical chemistry ,Salt (chemistry) ,Ionic bonding ,Radius ,law.invention ,Ion ,chemistry ,Volume (thermodynamics) ,law ,Electrode ,Nano - Abstract
Transport numbers were determined in the pure fused salts LiNO/sub 3/, NaNO/sub 3/, KNO/sub 3/, and AgNO/sub 3/ by measuring the volume changes of the material in the electrode compartments which took place during electrolysis of the melt. Transport numbers in the two binary fused salt systems AgNO/sub 3/- NaNO/sub 3/ and AgNO/sub 3/- KNO/sub 3/ were determined by measuring the volume changes accompanying electrolysis and the concentration changes accompanying electrolysis. The transport numbers of the pure fused salts were found to agree with a radius fraction expression which implied that the mobility of an ion moving through a melt is inversely proportional to its size. It is pointed out that this equation failed for other fused salts, so, factors other than the size must also affect the mobility of the ions in a fused salt. The variation with composition of the cation mobilities in the binary systems studied is discussed in terms of ordered and disordered regions in the melt. (auth)
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- 2018
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25. Long-Term Safety of Fevipiprant (QAW039) in Patients with Asthma, Inadequately Controlled on Standard-of-Care Therapy: Design of The Phase III SPIRIT Trial
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Kerwin, E.M., primary, Kato, M., additional, Maspero, J.F., additional, Felser, J.M., additional, Boone, B., additional, Smolen, M., additional, Wang, S., additional, and Knorr, B.A., additional
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- 2019
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26. Electrically Driven Implantable Prostheses
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Salkind, Alvin J., Spotnitz, Alan J., Berkovits, Barouh V., Owens, Boone B., Stokes, Kenneth B., Bilitch, Michael, and Owens, Boone B., editor
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- 1986
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27. Key Events in the Evolution of Implantable Pacemaker Batteries
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Owens, Boone B., Salkind, Alvin J., and Owens, Boone B., editor
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- 1986
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28. Optical and microwave detection using Bi-Sr-Ca-Cu-O thin films
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Grabow, B. E, Sova, R. M, Boone, B. G, Moorjani, K, Kim, B. F, Bohandy, J, Adrian, F, and Green, W. J
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Solid-State Physics - Abstract
Recent progress at the Johns Hopkins University Applied Physics Laboratory (JHU/APL) in the development of optical and microwave detectors using high temperature superconducting thin films is described. Several objectives of this work have been accomplished, including: deposition of Bi-Sr-Ca-Cu-O thin films by laser abation processing (LAP); development of thin film patterning techniques, including in situ masking, wet chemical etching, and laser patterning; measurements of bolometric and non-bolometric signatures in patterned Bi-Sr-Ca-Cu-O films using optical and microwave sources, respectively; analysis and design of an optimized bolometer through computer simulation; and investigation of its use in a Fourier transform spectrometer. The focus here is primarily on results from the measurement of the bolometric and non-bolometric response.
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- 1991
29. Laser‐assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's disease: a randomized intrapatient comparison between a continuous and a fractional ablative CO2 laser mode
- Author
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Genouw, E., primary, Verheire, B., additional, Ongenae, K., additional, De Schepper, S., additional, Creytens, D., additional, Verhaeghe, E., additional, and Boone, B., additional
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- 2018
- Full Text
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30. Optical and microwave detection using Bi-Sr-Ca-Cu-O thin films
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Grabow, B. E, Sova, R. M, Boone, B. G, Moorjani, K, Kim, B. F, Bohandy, J, Adrian, F, and Green, W. J
- Subjects
Solid-State Physics - Abstract
Recent progress at the Johns Hopkins University Applied Physics Laboratory (JHU/APL) in the development of optical and microwave detectors using high temperature superconducting thin films is described. Several objectives of this work have been accomplished, including: deposition of Bi-Sr-Ca-Cu-O thin films by laser abation processing (LAP); development of thin film patterning techniques, including in situ masking, wet chemical etching and laser patterning; measurements of bolometric and non-bolometric signatures in patterned Bi-Sr-Ca-Cu-O films using optical and microwave sources, respectively; analysis and design of an optimized bolometer through computer simulation, and investigation of its use in a Fourier transform spectrometer. The focus here is primarily on results from the measurement of the bolometric and non-bolometric response.
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- 1990
31. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
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Nicolas, A, Kenna, K, Renton, A, Ticozzi, N, Faghri, F, Chia, R, Dominov, J, Kenna, B, Nalls, M, Keagle, P, Rivera, A, van Rheenen, W, Murphy, N, van Vugt, J, Geiger, J, van der Spek, R, Pliner, H, Shankaracharya, N, Smith, B, Marangi, G, Topp, S, Abramzon, Y, Gkazi, A, Eicher, J, Kenna, A, Logullo, F, Simone, I, Logroscino, G, Salvi, F, Bartolomei, I, Borghero, G, Murru, M, Costantino, E, Pani, C, Puddu, R, Caredda, C, Piras, V, Tranquilli, S, Cuccu, S, Corongiu, D, Melis, M, Milia, A, Marrosu, F, Marrosu, M, Floris, G, Cannas, A, Capasso, M, Caponnetto, C, Mancardi, G, Origone, P, Mandich, P, Conforti, F, Cavallaro, S, Mora, G, Marinou, K, Sideri, R, Penco, S, Mosca, L, Lunetta, C, Pinter, G, Corbo, M, Riva, N, Carrera, P, Volanti, P, Mandrioli, J, Fini, N, Fasano, A, Tremolizzo, L, Arosio, A, Ferrarese, C, Trojsi, F, Tedeschi, G, Monsurrò, M, Piccirillo, G, Femiano, C, Ticca, A, Ortu, E, La Bella, V, Spataro, R, Colletti, T, Sabatelli, M, Zollino, M, Conte, A, Luigetti, M, Lattante, S, Santarelli, M, Petrucci, A, Pugliatti, M, Pirisi, A, Parish, L, Occhineri, P, Giannini, F, Battistini, S, Ricci, C, Benigni, M, Cau, T, Loi, D, Calvo, A, Moglia, C, Brunetti, M, Barberis, M, Restagno, G, Casale, F, Marrali, G, Fuda, G, Ossola, I, Cammarosano, S, Canosa, A, Ilardi, A, Manera, U, Grassano, M, Tanel, R, Pisano, F, Mazzini, L, Messina, S, D'Alfonso, S, Corrado, L, Ferrucci, L, Harms, M, Goldstein, D, Shneider, N, Goutman, S, Simmons, Z, Miller, T, Chandran, S, Pal, S, Manousakis, G, Appel, S, Simpson, E, Wang, L, Baloh, R, Gibson, S, Bedlack, R, Lacomis, D, Sareen, D, Sherman, A, Bruijn, L, Penny, M, Moreno, C, Kamalakaran, S, Allen, A, Boone, B, Brown, R, Carulli, J, Chesi, A, Chung, W, Cirulli, E, Cooper, G, Couthouis, J, Day-Williams, A, Dion, P, Gitler, A, Glass, J, Han, Y, Harris, T, Hayes, S, Jones, A, Keebler, J, Krueger, B, Lasseigne, B, Levy, S, Lu, Y, Maniatis, T, McKenna-Yasek, D, Myers, R, Petrovski, S, Pulst, S, Raphael, A, Ravits, J, Ren, Z, Rouleau, G, Sapp, P, Sims, K, Staropoli, J, Waite, L, Wang, Q, Wimbish, J, Xin, W, Phatnani, H, Kwan, J, Broach, J, Arcila-Londono, X, Lee, E, Van Deerlin, V, Fraenkel, E, Ostrow, L, Baas, F, Zaitlen, N, Berry, J, Malaspina, A, Fratta, P, Cox, G, Thompson, L, Finkbeiner, S, Dardiotis, E, Hornstein, E, Macgowan, D, Heiman-Patterson, T, Hammell, M, Patsopoulos, N, Dubnau, J, Nath, A, Musunuri, R, Evani, U, Abhyankar, A, Zody, M, Kaye, J, Wyman, S, Lenail, A, Lima, L, Rothstein, J, Svendsen, C, Van Eyk, J, Maragakis, N, Kolb, S, Cudkowicz, M, Baxi, E, Benatar, M, Taylor, J, Wu, G, Rampersaud, E, Wuu, J, Rademakers, R, Züchner, S, Schule, R, Mccauley, J, Hussain, S, Cooley, A, Wallace, M, Clayman, C, Barohn, R, Statland, J, Swenson, A, Jackson, C, Trivedi, J, Khan, S, Katz, J, Jenkins, L, Burns, T, Gwathmey, K, Caress, J, Mcmillan, C, Elman, L, Pioro, E, Heckmann, J, So, Y, Walk, D, Maiser, S, Zhang, J, Silani, V, Gellera, C, Ratti, A, Taroni, F, Lauria, G, Verde, F, Fogh, I, Tiloca, C, Comi, G, Sorarù, G, Cereda, C, De Marchi, F, Corti, S, Ceroni, M, Siciliano, G, Filosto, M, Inghilleri, M, Peverelli, S, Colombrita, C, Poletti, B, Maderna, L, Del Bo, R, Gagliardi, S, Querin, G, Bertolin, C, Pensato, V, Castellotti, B, Camu, W, Mouzat, K, Lumbroso, S, Corcia, P, Meininger, V, Besson, G, Lagrange, E, Clavelou, P, Guy, N, Couratier, P, Vourch, P, Danel, V, Bernard, E, Lemasson, G, Laaksovirta, H, Myllykangas, L, Jansson, L, Valori, M, Ealing, J, Hamdalla, H, Rollinson, S, Pickering-Brown, S, Orrell, R, Sidle, K, Hardy, J, Singleton, A, Johnson, J, Arepalli, S, Polak, M, Asress, S, Al-Sarraj, S, King, A, Troakes, C, Vance, C, de Belleroche, J, ten Asbroek, A, Muñoz-Blanco, J, Hernandez, D, Ding, J, Gibbs, J, Scholz, S, Floeter, M, Campbell, R, Landi, F, Bowser, R, Kirby, J, Pamphlett, R, Gerhard, G, Dunckley, T, Brady, C, Kowall, N, Troncoso, J, Le Ber, I, Kamel, F, Van Den Bosch, L, Strom, T, Meitinger, T, Shatunov, A, Van Eijk, K, de Carvalho, M, Kooyman, M, Middelkoop, B, Moisse, M, Mclaughlin, R, Van Es, M, Weber, M, Boylan, K, Van Blitterswijk, M, Morrison, K, Basak, A, Mora, J, Drory, V, Shaw, P, Turner, M, Talbot, K, Hardiman, O, Williams, K, Fifita, J, Nicholson, G, Blair, I, Esteban-Pérez, J, García-Redondo, A, Al-Chalabi, A, Al Kheifat, A, Andersen, P, Chio, A, Cooper-Knock, J, Dekker, A, Redondo, A, Gotkine, M, Hide, W, Iacoangeli, A, Kiernan, M, Landers, J, Mill, J, Neto, M, Pardina, J, Newhouse, S, Pinto, S, Pulit, S, Robberecht, W, Shaw, C, Sproviero, W, Tazelaar, G, van Damme, P, van den Berg, L, van Eijk, K, van Es, M, Veldink, J, Zatz, M, Bauer, D, Twine, N, Rogaeva, E, Zinman, L, Brice, A, Feldman, E, Ludolph, A, Weishaupt, J, Trojanowski, J, Stone, D, Tienari, P, Chiò, A, Traynor, B, Nicolas, Aude, Kenna, Kevin P., Renton, Alan E., Ticozzi, Nicola, Faghri, Faraz, Chia, Ruth, Dominov, Janice A., Kenna, Brendan J., Nalls, Mike A., Keagle, Pamela, Rivera, Alberto M., van Rheenen, Wouter, Murphy, Natalie A., van Vugt, Joke J. F. A., Geiger, Joshua T., van der Spek, Rick, Pliner, Hannah A., Shankaracharya, null, Smith, Bradley N., Marangi, Giuseppe, Topp, Simon D., Abramzon, Yevgeniya, Gkazi, Athina Soragia, Eicher, John D., Kenna, Aoife, Logullo, Francesco O., Simone, Isabella, Logroscino, Giancarlo, Salvi, Fabrizio, Bartolomei, Ilaria, Borghero, Giuseppe, Murru, Maria Rita, Costantino, Emanuela, Pani, Carla, Puddu, Roberta, Caredda, Carla, Piras, Valeria, Tranquilli, Stefania, Cuccu, Stefania, Corongiu, Daniela, Melis, Maurizio, Milia, Antonio, Marrosu, Francesco, Marrosu, Maria Giovanna, Floris, Gianluca, Cannas, Antonino, Capasso, Margherita, Caponnetto, Claudia, Mancardi, Gianluigi, Origone, Paola, Mandich, Paola, Conforti, Francesca L., Cavallaro, Sebastiano, Mora, Gabriele, Marinou, Kalliopi, Sideri, Riccardo, Penco, Silvana, Mosca, Lorena, Lunetta, Christian, Pinter, Giuseppe Lauria, Corbo, Massimo, Riva, Nilo, Carrera, Paola, Volanti, Paolo, Mandrioli, Jessica, Fini, Nicola, Fasano, Antonio, Tremolizzo, Lucio, Arosio, Alessandro, Ferrarese, Carlo, Trojsi, Francesca, Tedeschi, Gioacchino, Monsurrò, Maria Rosaria, Piccirillo, Giovanni, Femiano, Cinzia, Ticca, Anna, Ortu, Enzo, La Bella, Vincenzo, Spataro, Rossella, Colletti, Tiziana, Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, Marialuisa, Petrucci, Antonio, Pugliatti, Maura, Pirisi, Angelo, Parish, Leslie D., Occhineri, Patrizia, Giannini, Fabio, Battistini, Stefania, Ricci, Claudia, Benigni, Michele, Cau, Tea B., Loi, Daniela, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Barberis, Marco, Restagno, Gabriella, Casale, Federico, Marrali, Giuseppe, Fuda, Giuseppe, Ossola, Irene, Cammarosano, Stefania, Canosa, Antonio, Ilardi, Antonio, Manera, Umberto, Grassano, Maurizio, Tanel, Raffaella, Pisano, Fabrizio, Mazzini, Letizia, Messina, Sonia, D'Alfonso, Sandra, Corrado, Lucia, Ferrucci, Luigi, Harms, Matthew B., Goldstein, David B., Shneider, Neil A., Goutman, Stephen, Simmons, Zachary, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Manousakis, George, Appel, Stanley, Simpson, Ericka, Wang, Leo, Baloh, Robert H., Gibson, Summer, Bedlack, Richard S., Lacomis, David, Sareen, Dhruv, Sherman, Alexander, Bruijn, Lucie, Penny, Michelle, Moreno, Cristiane de Araujo Martins, Kamalakaran, Sitharthan, Allen, Andrew S., Boone, Braden E., Brown, Robert, Carulli, John P., Chesi, Alessandra, Chung, Wendy K., Cirulli, Elizabeth T., Cooper, Gregory M., Couthouis, Julien, Day-Williams, Aaron G., Dion, Patrick A., Gitler, Aaron D., Glass, Jonathan D., Han, Yujun, Harris, Tim, Hayes, Sebastian D., Jones, Angela L., Keebler, Jonathan, Krueger, Brian J., Lasseigne, Brittany N., Levy, Shawn E., Lu, Yi-Fan, Maniatis, Tom, McKenna-Yasek, Diane, Myers, Richard M., Petrovski, Slavé, Pulst, Stefan M., Raphael, Alya R., Ravits, John M., Ren, Zhong, Rouleau, Guy A., Sapp, Peter C., Sims, Katherine B., Staropoli, John F., Waite, Lindsay L., Wang, Quanli, Wimbish, Jack R., Xin, Winnie W., Phatnani, Hemali, Kwan, Justin, Broach, James R., Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steven, Dardiotis, Efthimios, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos A., Dubnau, Joshua, Nath, Avindra, Musunuri, Rajeeva Lochan, Evani, Uday Shankar, Abhyankar, Avinash, Zody, Michael C., Kaye, Julia, Wyman, Stacia, LeNail, Alexander, Lima, Leandro, Rothstein, Jeffrey D., Svendsen, Clive N., Van Eyk, Jenny, Maragakis, Nicholas J., Kolb, Stephen J., Cudkowicz, Merit, Baxi, Emily, Wyman, Stacia K., Van Eyk, Jennifer E., Benatar, Michael, Taylor, J. Paul, Wu, Gang, Rampersaud, Evadnie, Wuu, Joanne, Rademakers, Rosa, Züchner, Stephan, Schule, Rebecca, McCauley, Jacob, Hussain, Sumaira, Cooley, Anne, Wallace, Marielle, Clayman, Christine, Barohn, Richard, Statland, Jeffrey, Ravits, John, Swenson, Andrea, Jackson, Carlayne, Trivedi, Jaya, Khan, Shaida, Katz, Jonathan, Jenkins, Liberty, Burns, Ted, Gwathmey, Kelly, Caress, James, McMillan, Corey, Elman, Lauren, Pioro, Erik, Heckmann, Jeannine, So, Yuen, Walk, David, Maiser, Samuel, Zhang, Jinghui, Silani, Vincenzo, Gellera, Cinzia, Ratti, Antonia, Taroni, Franco, Lauria, Giuseppe, Verde, Federico, Fogh, Isabella, Tiloca, Cinzia, Comi, Giacomo P., Sorarù, Gianni, Cereda, Cristina, De Marchi, Fabiola, Corti, Stefania, Ceroni, Mauro, Siciliano, Gabriele, Filosto, Massimiliano, Inghilleri, Maurizio, Peverelli, Silvia, Colombrita, Claudia, Poletti, Barbara, Maderna, Luca, Del Bo, Roberto, Gagliardi, Stella, Querin, Giorgia, Bertolin, Cinzia, Pensato, Viviana, Castellotti, Barbara, Camu, William, Mouzat, Kevin, Lumbroso, Serge, Corcia, Philippe, Meininger, Vincent, Besson, Gérard, Lagrange, Emmeline, Clavelou, Pierre, Guy, Nathalie, Couratier, Philippe, Vourch, Patrick, Danel, Véronique, Bernard, Emilien, Lemasson, Gwendal, Laaksovirta, Hannu, Myllykangas, Liisa, Jansson, Lilja, Valori, Miko, Ealing, John, Hamdalla, Hisham, Rollinson, Sara, Pickering-Brown, Stuart, Orrell, Richard W., Sidle, Katie C., Hardy, John, Singleton, Andrew B., Johnson, Janel O., Arepalli, Sampath, Polak, Meraida, Asress, Seneshaw, Al-Sarraj, Safa, King, Andrew, Troakes, Claire, Vance, Caroline, de Belleroche, Jacqueline, ten Asbroek, Anneloor L. M. A., Muñoz-Blanco, José Luis, Hernandez, Dena G., Ding, Jinhui, Gibbs, J. Raphael, Scholz, Sonja W., Floeter, Mary Kay, Campbell, Roy H., Landi, Francesco, Bowser, Robert, MacGowan, Daniel J. L., Kirby, Janine, Pioro, Erik P., Pamphlett, Roger, Broach, James, Gerhard, Glenn, Dunckley, Travis L., Brady, Christopher B., Kowall, Neil W., Troncoso, Juan C., Le Ber, Isabelle, Heiman-Patterson, Terry D., Kamel, Freya, Van Den Bosch, Ludo, Strom, Tim M., Meitinger, Thomas, Shatunov, Aleksey, Van Eijk, Kristel R., de Carvalho, Mamede, Kooyman, Maarten, Middelkoop, Bas, Moisse, Mattieu, McLaughlin, Russell L., Van Es, Michael A., Weber, Markus, Boylan, Kevin B., Van Blitterswijk, Marka, Morrison, Karen E., Basak, A. Nazli, Mora, Jesús S., Drory, Vivian E., Shaw, Pamela J., Turner, Martin R., Talbot, Kevin, Hardiman, Orla, Williams, Kelly L., Fifita, Jennifer A., Nicholson, Garth A., Blair, Ian P., Esteban-Pérez, Jesús, García-Redondo, Alberto, Al-Chalabi, Ammar, Al Kheifat, Ahmad, Andersen, Peter, Chio, Adriano, Cooper-Knock, Jonathan, Dekker, Annelot, Drory, Vivian, Redondo, Alberto Garcia, Gotkine, Marc, Hide, Winston, Iacoangeli, Alfredo, Glass, Jonathan, Kenna, Kevin, Kiernan, Matthew, Landers, John, McLaughlin, Russell, Mill, Jonathan, Neto, Miguel Mitne, Pardina, Jesus Mora, Morrison, Karen, Newhouse, Stephen, Pinto, Susana, Pulit, Sara, Robberecht, Wim, Shaw, Pamela, Shaw, Chris, Sproviero, William, Tazelaar, Gijs, van Damme, Philip, van den Berg, Leonard, van Eijk, Kristel, van Es, Michael, van Vugt, Joke, Veldink, Jan, Zatz, Mayana, Bauer, Denis C., Twine, Natalie A., Rogaeva, Ekaterina, Zinman, Lorne, Brice, Alexis, Goutman, Stephen A., Feldman, Eva L., Gibson, Summer B., Ludolph, Albert C., Andersen, Peter M., Weishaupt, Jochen H., Trojanowski, John Q., Brown, Robert H., van den Berg, Leonard H., Veldink, Jan H., Stone, David J., Tienari, Pentti, Chiò, Adriano, Shaw, Christopher E., Traynor, Bryan J., Landers, John E., Nicolas, A, Kenna, K, Renton, A, Ticozzi, N, Faghri, F, Chia, R, Dominov, J, Kenna, B, Nalls, M, Keagle, P, Rivera, A, van Rheenen, W, Murphy, N, van Vugt, J, Geiger, J, van der Spek, R, Pliner, H, Shankaracharya, N, Smith, B, Marangi, G, Topp, S, Abramzon, Y, Gkazi, A, Eicher, J, Kenna, A, Logullo, F, Simone, I, Logroscino, G, Salvi, F, Bartolomei, I, Borghero, G, Murru, M, Costantino, E, Pani, C, Puddu, R, Caredda, C, Piras, V, Tranquilli, S, Cuccu, S, Corongiu, D, Melis, M, Milia, A, Marrosu, F, Marrosu, M, Floris, G, Cannas, A, Capasso, M, Caponnetto, C, Mancardi, G, Origone, P, Mandich, P, Conforti, F, Cavallaro, S, Mora, G, Marinou, K, Sideri, R, Penco, S, Mosca, L, Lunetta, C, Pinter, G, Corbo, M, Riva, N, Carrera, P, Volanti, P, Mandrioli, J, Fini, N, Fasano, A, Tremolizzo, L, Arosio, A, Ferrarese, C, Trojsi, F, Tedeschi, G, Monsurrò, M, Piccirillo, G, Femiano, C, Ticca, A, Ortu, E, La Bella, V, Spataro, R, Colletti, T, Sabatelli, M, Zollino, M, Conte, A, Luigetti, M, Lattante, S, Santarelli, M, Petrucci, A, Pugliatti, M, Pirisi, A, Parish, L, Occhineri, P, Giannini, F, Battistini, S, Ricci, C, Benigni, M, Cau, T, Loi, D, Calvo, A, Moglia, C, Brunetti, M, Barberis, M, Restagno, G, Casale, F, Marrali, G, Fuda, G, Ossola, I, Cammarosano, S, Canosa, A, Ilardi, A, Manera, U, Grassano, M, Tanel, R, Pisano, F, Mazzini, L, Messina, S, D'Alfonso, S, Corrado, L, Ferrucci, L, Harms, M, Goldstein, D, Shneider, N, Goutman, S, Simmons, Z, Miller, T, Chandran, S, Pal, S, Manousakis, G, Appel, S, Simpson, E, Wang, L, Baloh, R, Gibson, S, Bedlack, R, Lacomis, D, Sareen, D, Sherman, A, Bruijn, L, Penny, M, Moreno, C, Kamalakaran, S, Allen, A, Boone, B, Brown, R, Carulli, J, Chesi, A, Chung, W, Cirulli, E, Cooper, G, Couthouis, J, 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J, Khan, S, Katz, J, Jenkins, L, Burns, T, Gwathmey, K, Caress, J, Mcmillan, C, Elman, L, Pioro, E, Heckmann, J, So, Y, Walk, D, Maiser, S, Zhang, J, Silani, V, Gellera, C, Ratti, A, Taroni, F, Lauria, G, Verde, F, Fogh, I, Tiloca, C, Comi, G, Sorarù, G, Cereda, C, De Marchi, F, Corti, S, Ceroni, M, Siciliano, G, Filosto, M, Inghilleri, M, Peverelli, S, Colombrita, C, Poletti, B, Maderna, L, Del Bo, R, Gagliardi, S, Querin, G, Bertolin, C, Pensato, V, Castellotti, B, Camu, W, Mouzat, K, Lumbroso, S, Corcia, P, Meininger, V, Besson, G, Lagrange, E, Clavelou, P, Guy, N, Couratier, P, Vourch, P, Danel, V, Bernard, E, Lemasson, G, Laaksovirta, H, Myllykangas, L, Jansson, L, Valori, M, Ealing, J, Hamdalla, H, Rollinson, S, Pickering-Brown, S, Orrell, R, Sidle, K, Hardy, J, Singleton, A, Johnson, J, Arepalli, S, Polak, M, Asress, S, Al-Sarraj, S, King, A, Troakes, C, Vance, C, de Belleroche, J, ten Asbroek, A, Muñoz-Blanco, J, Hernandez, D, Ding, J, Gibbs, J, Scholz, S, Floeter, M, Campbell, 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A., Geiger, Joshua T., van der Spek, Rick, Pliner, Hannah A., Shankaracharya, null, Smith, Bradley N., Marangi, Giuseppe, Topp, Simon D., Abramzon, Yevgeniya, Gkazi, Athina Soragia, Eicher, John D., Kenna, Aoife, Logullo, Francesco O., Simone, Isabella, Logroscino, Giancarlo, Salvi, Fabrizio, Bartolomei, Ilaria, Borghero, Giuseppe, Murru, Maria Rita, Costantino, Emanuela, Pani, Carla, Puddu, Roberta, Caredda, Carla, Piras, Valeria, Tranquilli, Stefania, Cuccu, Stefania, Corongiu, Daniela, Melis, Maurizio, Milia, Antonio, Marrosu, Francesco, Marrosu, Maria Giovanna, Floris, Gianluca, Cannas, Antonino, Capasso, Margherita, Caponnetto, Claudia, Mancardi, Gianluigi, Origone, Paola, Mandich, Paola, Conforti, Francesca L., Cavallaro, Sebastiano, Mora, Gabriele, Marinou, Kalliopi, Sideri, Riccardo, Penco, Silvana, Mosca, Lorena, Lunetta, Christian, Pinter, Giuseppe Lauria, Corbo, Massimo, Riva, Nilo, Carrera, Paola, Volanti, Paolo, Mandrioli, Jessica, Fini, Nicola, Fasano, Antonio, Tremolizzo, Lucio, Arosio, Alessandro, Ferrarese, Carlo, Trojsi, Francesca, Tedeschi, Gioacchino, Monsurrò, Maria Rosaria, Piccirillo, Giovanni, Femiano, Cinzia, Ticca, Anna, Ortu, Enzo, La Bella, Vincenzo, Spataro, Rossella, Colletti, Tiziana, Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, Marialuisa, Petrucci, Antonio, Pugliatti, Maura, Pirisi, Angelo, Parish, Leslie D., Occhineri, Patrizia, Giannini, Fabio, Battistini, Stefania, Ricci, Claudia, Benigni, Michele, Cau, Tea B., Loi, Daniela, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Barberis, Marco, Restagno, Gabriella, Casale, Federico, Marrali, Giuseppe, Fuda, Giuseppe, Ossola, Irene, Cammarosano, Stefania, Canosa, Antonio, Ilardi, Antonio, Manera, Umberto, Grassano, Maurizio, Tanel, Raffaella, Pisano, Fabrizio, Mazzini, Letizia, Messina, Sonia, D'Alfonso, Sandra, Corrado, Lucia, Ferrucci, Luigi, Harms, Matthew B., Goldstein, David B., Shneider, Neil A., Goutman, Stephen, Simmons, Zachary, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Manousakis, George, Appel, Stanley, Simpson, Ericka, Wang, Leo, Baloh, Robert H., Gibson, Summer, Bedlack, Richard S., Lacomis, David, Sareen, Dhruv, Sherman, Alexander, Bruijn, Lucie, Penny, Michelle, Moreno, Cristiane de Araujo Martins, Kamalakaran, Sitharthan, Allen, Andrew S., Boone, Braden E., Brown, Robert, Carulli, John P., Chesi, Alessandra, Chung, Wendy K., Cirulli, Elizabeth T., Cooper, Gregory M., Couthouis, Julien, Day-Williams, Aaron G., Dion, Patrick A., Gitler, Aaron D., Glass, Jonathan D., Han, Yujun, Harris, Tim, Hayes, Sebastian D., Jones, Angela L., Keebler, Jonathan, Krueger, Brian J., Lasseigne, Brittany N., Levy, Shawn E., Lu, Yi-Fan, Maniatis, Tom, McKenna-Yasek, Diane, Myers, Richard M., Petrovski, Slavé, Pulst, Stefan M., Raphael, Alya R., Ravits, John M., Ren, Zhong, Rouleau, Guy A., Sapp, Peter C., Sims, Katherine B., Staropoli, John F., Waite, Lindsay L., Wang, Quanli, Wimbish, Jack R., Xin, Winnie W., Phatnani, Hemali, Kwan, Justin, Broach, James R., Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steven, Dardiotis, Efthimios, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos A., Dubnau, Joshua, Nath, Avindra, Musunuri, Rajeeva Lochan, Evani, Uday Shankar, Abhyankar, Avinash, Zody, Michael C., Kaye, Julia, Wyman, Stacia, LeNail, Alexander, Lima, Leandro, Rothstein, Jeffrey D., Svendsen, Clive N., Van Eyk, Jenny, Maragakis, Nicholas J., Kolb, Stephen J., Cudkowicz, Merit, Baxi, Emily, Wyman, Stacia K., Van Eyk, Jennifer E., Benatar, Michael, Taylor, J. 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- Abstract
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS. Using a large-scale genome-wide association study and exome sequencing, we identified KIF5A as a novel gene associated with ALS. Our data broaden the phenotype resulting from mutations in KIF5A and highlight the importance of cytoskeletal defects in the pathogenesis of ALS.
- Published
- 2018
32. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
- Author
-
Nicolas, A., Kenna, K. P., Renton, A. E., Ticozzi, N., Faghri, F., Chia, R., Dominov, J. A., Kenna, B. J., Nalls, M. A., Keagle, P., Rivera, A. M., van Rheenen, W., Murphy, N. A., van Vugt, J. J. F. A., Geiger, J. T., Van der Spek, R. A., Pliner, H. A., Shankaracharya, Smith, B. N., Marangi, Giuseppe, Topp, S. D., Abramzon, Y., Gkazi, A. S., Eicher, J. D., Kenna, A., Logullo, F. O., Simone, I. L., Logroscino, Giandomenico, Salvi, F., Bartolomei, I., Borghero, G., Murru, M. R., Costantino, E., Pani, C., Puddu, R., Caredda, C., Piras, V., Tranquilli, S., Cuccu, S., Corongiu, D., Melis, M., Milia, A., Marrosu, F., Marrosu, M. G., Floris, G., Cannas, A., Capasso, Monica, Caponnetto, C., Mancardi, G., Origone, P., Mandich, P., Conforti, F. L., Cavallaro, S., Mora, G., Marinou, K., Sideri, R., Penco, S., Mosca, Luigi, Lunetta, C., Pinter, G. L., Corbo, M., Riva, N., Carrera, P., Volanti, P., Mandrioli, J., Fini, N., Fasano, Alfonso, Tremolizzo, L., Arosio, A., Ferrarese, C., Trojsi, F., Tedeschi, G., Monsurro, M. R., Piccirillo, G., Femiano, C., Ticca, A., Ortu, E., La Bella, V., Spataro, R., Colletti, T., Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, M., Petrucci, A., Pugliatti, M., Pirisi, A., Parish, L. D., Occhineri, P., Giannini, F., Battistini, S., Ricci, C., Benigni, M., Cau, T. B., Loi, D., Calvo, A., Moglia, C., Brunetti, M., Barberis, M., Restagno, G., Casale, F., Marrali, G., Fuda, G., Ossola, I., Cammarosano, S., Canosa, A., Ilardi, A., Manera, U., Grassano, M., Tanel, R., Pisano, F., Mazzini, L., Messina, S., D'Alfonso, Sandra, Corrado, L., Ferrucci, L., Harms, M. B., Goldstein, D. B., Shneider, N. A., Goutman, S. A., Simmons, Z., Miller, T. M., Chandran, S., Pal, S., Manousakis, G., Appel, S. H., Simpson, E., Wang, L., Baloh, R. H., Gibson, S. B., Bedlack, R., Lacomis, D., Sareen, D., Sherman, A., Bruijn, L., Penny, M., Moreno, C. D. A. M., Kamalakaran, S., Allen, A. S., Boone, B. E., Brown, R. H., Carulli, J. P., Chesi, A., Chung, W. K., Cirulli, E. T., Cooper, G. M., Couthouis, J., Day-Williams, A. G., Dion, P. A., Gitler, A. D., Glass, J. D., Han, Y., Harris, T., Hayes, S. D., Jones, A. L., Keebler, J., Krueger, B. J., Lasseigne, B. N., Levy, S. E., Lu, Y. -F., Maniatis, T., McKenna-Yasek, D., Myers, R. M., Petrovski, S., Pulst, S. M., Raphael, A. R., Ravits, J. M., Ren, Z., Rouleau, G. A., Sapp, P. C., Sims, K. B., Staropoli, J. F., Waite, L. L., Wang, Quanquan, Wimbish, J. R., Xin, W. W., Phatnani, H., Kwan, J., Broach, J., Arcila-Londono, X., Lee, E. B., Van Deerlin, V. M., Fraenkel, E., Ostrow, L. W., Baas, F., Zaitlen, N., Berry, J. D., Malaspina, A., Fratta, P., Cox, G. A., Thompson, L. M., Finkbeiner, S., Dardiotis, E., Hornstein, E., Macgowan, D. J. L., Heiman-Patterson, T., Hammell, M. G., Patsopoulos, N. A., Dubnau, J., Nath, A., Musunuri, R. L., Evani, U. S., Abhyankar, A., Zody, M. C., Kaye, J., Wyman, S. K., Lenail, A., Lima, L., Rothstein, J. D., Svendsen, C. N., Van Eyk, J. E., Maragakis, N. J., Kolb, S. J., Cudkowicz, M., Baxi, E., Benatar, M., Taylor, J. P., Wu, G., Rampersaud, E., Wuu, J., Rademakers, R., Zuchner, S., Schule, R., Mccauley, J., Hussain, S., Cooley, A., Wallace, M., Clayman, C., Barohn, R., Statland, J., Swenson, A., Jackson, C., Trivedi, J., Khan, S., Katz, J., Jenkins, L., Burns, T., Gwathmey, K., Caress, J., Mcmillan, C., Elman, L., Pioro, E. P., Heckmann, J., So, Y., Walk, D., Maiser, S., Zhang, J., Silani, V., Gellera, C., Ratti, A., Taroni, F., Lauria, G., Verde, F., Fogh, I., Tiloca, C., Comi, G. P., Soraru, G., Cereda, C., De Marchi, F., Corti, S., Ceroni, M., Siciliano, Giovanni, Filosto, M., Inghilleri, M., Peverelli, S., Colombrita, C., Poletti, B., Maderna, L., Del Bo, R., Gagliardi, S., Querin, G., Bertolin, C., Pensato, V., Castellotti, B., Camu, W., Mouzat, K., Lumbroso, S., Corcia, P., Meininger, V., Besson, G., Lagrange, E., Clavelou, P., Guy, N., Couratier, P., Vourch, P., Danel, V., Bernard, E., Lemasson, G., Laaksovirta, H., Myllykangas, L., Jansson, L., Valori, Vanna Maria, Ealing, J., Hamdalla, H., Rollinson, S., Pickering-Brown, S., Orrell, R. W., Sidle, K. C., Hardy, J., Singleton, A. B., Johnson, J. O., Arepalli, S., Polak, M., Asress, S., Al-Sarraj, S., King, A., Troakes, C., Vance, C., de Belleroche, J., ten Asbroek, A. L. M. A., Munoz-Blanco, J. L., Hernandez, D. G., Ding, J., Gibbs, J. R., Scholz, S. W., Floeter, M. K., Campbell, R. H., Landi, Francesco, Bowser, R., Kirby, J., Pamphlett, R., Gerhard, G., Dunckley, T. L., Brady, C. B., Kowall, N. W., Troncoso, J. C., Le Ber, I., Heiman-Patterson, T. D., Kamel, F., Van Den Bosch, L., Strom, T. M., Meitinger, T., Shatunov, A., Van Eijk, K. R., de Carvalho, M., Kooyman, M., Middelkoop, B., Moisse, M., Mclaughlin, R. L., Van Es, M. A., Weber, M., Boylan, K. B., Van Blitterswijk, M., Morrison, K. E., Basak, A. N., Mora, J. S., Drory, V. E., Shaw, P. J., Turner, M. R., Talbot, K., Hardiman, O., Williams, K. L., Fifita, J. A., Nicholson, G. A., Blair, I. P., Esteban-Perez, J., Garcia-Redondo, A., Al-Chalabi, A., Al Kheifat, A., Andersen, P. M., Chio, A., Cooper-Knock, J., Dekker, A., Redondo, A. G., Gotkine, M., Hide, W., Iacoangeli, A., Kiernan, M., Landers, J. E., Mill, J., Neto, M. M., Pardina, J. M., Newhouse, S., Pinto, S., Pulit, S., Robberecht, W., Shaw, C., Sproviero, W., Tazelaar, G., Van Damme, P., van den Berg, L. H., van Vugt, J., Veldink, J. H., Zatz, M., Bauer, D. C., Twine, N. A., Rogaeva, E., Zinman, L., Brice, A., Feldman, E. L., Ludolph, A. C., Weishaupt, J. H., Trojanowski, J. Q., Stone, D. J., Tienari, P., Shaw, C. E., Traynor, B. J., Marangi G. (ORCID:0000-0002-6898-8882), Logroscino G. (ORCID:0000-0003-1301-5343), Capasso M., Mosca L. (ORCID:0000-0003-4641-0841), Fasano A., Sabatelli M. (ORCID:0000-0001-6635-4985), Zollino M. (ORCID:0000-0003-4871-9519), Conte A., Luigetti M. (ORCID:0000-0001-7539-505X), Lattante S. (ORCID:0000-0003-2891-0340), D'Alfonso S., Siciliano G., Valori M., Landi F. (ORCID:0000-0002-3472-1389), Nicolas, A., Kenna, K. P., Renton, A. E., Ticozzi, N., Faghri, F., Chia, R., Dominov, J. A., Kenna, B. J., Nalls, M. A., Keagle, P., Rivera, A. M., van Rheenen, W., Murphy, N. A., van Vugt, J. J. F. A., Geiger, J. T., Van der Spek, R. A., Pliner, H. A., Shankaracharya, Smith, B. N., Marangi, Giuseppe, Topp, S. D., Abramzon, Y., Gkazi, A. S., Eicher, J. D., Kenna, A., Logullo, F. O., Simone, I. L., Logroscino, Giandomenico, Salvi, F., Bartolomei, I., Borghero, G., Murru, M. R., Costantino, E., Pani, C., Puddu, R., Caredda, C., Piras, V., Tranquilli, S., Cuccu, S., Corongiu, D., Melis, M., Milia, A., Marrosu, F., Marrosu, M. G., Floris, G., Cannas, A., Capasso, Monica, Caponnetto, C., Mancardi, G., Origone, P., Mandich, P., Conforti, F. L., Cavallaro, S., Mora, G., Marinou, K., Sideri, R., Penco, S., Mosca, Luigi, Lunetta, C., Pinter, G. L., Corbo, M., Riva, N., Carrera, P., Volanti, P., Mandrioli, J., Fini, N., Fasano, Alfonso, Tremolizzo, L., Arosio, A., Ferrarese, C., Trojsi, F., Tedeschi, G., Monsurro, M. R., Piccirillo, G., Femiano, C., Ticca, A., Ortu, E., La Bella, V., Spataro, R., Colletti, T., Sabatelli, Mario, Zollino, Marcella, Conte, Amelia, Luigetti, Marco, Lattante, Serena, Santarelli, M., Petrucci, A., Pugliatti, M., Pirisi, A., Parish, L. D., Occhineri, P., Giannini, F., Battistini, S., Ricci, C., Benigni, M., Cau, T. B., Loi, D., Calvo, A., Moglia, C., Brunetti, M., Barberis, M., Restagno, G., Casale, F., Marrali, G., Fuda, G., Ossola, I., Cammarosano, S., Canosa, A., Ilardi, A., Manera, U., Grassano, M., Tanel, R., Pisano, F., Mazzini, L., Messina, S., D'Alfonso, Sandra, Corrado, L., Ferrucci, L., Harms, M. B., Goldstein, D. B., Shneider, N. A., Goutman, S. A., Simmons, Z., Miller, T. M., Chandran, S., Pal, S., Manousakis, G., Appel, S. H., Simpson, E., Wang, L., Baloh, R. H., Gibson, S. B., Bedlack, R., Lacomis, D., Sareen, D., Sherman, A., Bruijn, L., Penny, M., Moreno, C. D. A. M., Kamalakaran, S., Allen, A. S., Boone, B. E., Brown, R. H., Carulli, J. P., Chesi, A., Chung, W. K., Cirulli, E. T., Cooper, G. M., Couthouis, J., Day-Williams, A. G., Dion, P. A., Gitler, A. D., Glass, J. D., Han, Y., Harris, T., Hayes, S. D., Jones, A. L., Keebler, J., Krueger, B. J., Lasseigne, B. N., Levy, S. E., Lu, Y. -F., Maniatis, T., McKenna-Yasek, D., Myers, R. M., Petrovski, S., Pulst, S. M., Raphael, A. R., Ravits, J. M., Ren, Z., Rouleau, G. A., Sapp, P. C., Sims, K. B., Staropoli, J. F., Waite, L. L., Wang, Quanquan, Wimbish, J. R., Xin, W. W., Phatnani, H., Kwan, J., Broach, J., Arcila-Londono, X., Lee, E. B., Van Deerlin, V. M., Fraenkel, E., Ostrow, L. W., Baas, F., Zaitlen, N., Berry, J. D., Malaspina, A., Fratta, P., Cox, G. A., Thompson, L. M., Finkbeiner, S., Dardiotis, E., Hornstein, E., Macgowan, D. J. L., Heiman-Patterson, T., Hammell, M. G., Patsopoulos, N. A., Dubnau, J., Nath, A., Musunuri, R. L., Evani, U. S., Abhyankar, A., Zody, M. C., Kaye, J., Wyman, S. K., Lenail, A., Lima, L., Rothstein, J. D., Svendsen, C. N., Van Eyk, J. E., Maragakis, N. J., Kolb, S. J., Cudkowicz, M., Baxi, E., Benatar, M., Taylor, J. P., Wu, G., Rampersaud, E., Wuu, J., Rademakers, R., Zuchner, S., Schule, R., Mccauley, J., Hussain, S., Cooley, A., Wallace, M., Clayman, C., Barohn, R., Statland, J., Swenson, A., Jackson, C., Trivedi, J., Khan, S., Katz, J., Jenkins, L., Burns, T., Gwathmey, K., Caress, J., Mcmillan, C., Elman, L., Pioro, E. P., Heckmann, J., So, Y., Walk, D., Maiser, S., Zhang, J., Silani, V., Gellera, C., Ratti, A., Taroni, F., Lauria, G., Verde, F., Fogh, I., Tiloca, C., Comi, G. P., Soraru, G., Cereda, C., De Marchi, F., Corti, S., Ceroni, M., Siciliano, Giovanni, Filosto, M., Inghilleri, M., Peverelli, S., Colombrita, C., Poletti, B., Maderna, L., Del Bo, R., Gagliardi, S., Querin, G., Bertolin, C., Pensato, V., Castellotti, B., Camu, W., Mouzat, K., Lumbroso, S., Corcia, P., Meininger, V., Besson, G., Lagrange, E., Clavelou, P., Guy, N., Couratier, P., Vourch, P., Danel, V., Bernard, E., Lemasson, G., Laaksovirta, H., Myllykangas, L., Jansson, L., Valori, Vanna Maria, Ealing, J., Hamdalla, H., Rollinson, S., Pickering-Brown, S., Orrell, R. W., Sidle, K. C., Hardy, J., Singleton, A. B., Johnson, J. O., Arepalli, S., Polak, M., Asress, S., Al-Sarraj, S., King, A., Troakes, C., Vance, C., de Belleroche, J., ten Asbroek, A. L. M. A., Munoz-Blanco, J. L., Hernandez, D. G., Ding, J., Gibbs, J. R., Scholz, S. W., Floeter, M. K., Campbell, R. H., Landi, Francesco, Bowser, R., Kirby, J., Pamphlett, R., Gerhard, G., Dunckley, T. L., Brady, C. B., Kowall, N. W., Troncoso, J. C., Le Ber, I., Heiman-Patterson, T. D., Kamel, F., Van Den Bosch, L., Strom, T. M., Meitinger, T., Shatunov, A., Van Eijk, K. R., de Carvalho, M., Kooyman, M., Middelkoop, B., Moisse, M., Mclaughlin, R. L., Van Es, M. A., Weber, M., Boylan, K. B., Van Blitterswijk, M., Morrison, K. E., Basak, A. N., Mora, J. S., Drory, V. E., Shaw, P. J., Turner, M. R., Talbot, K., Hardiman, O., Williams, K. L., Fifita, J. A., Nicholson, G. A., Blair, I. P., Esteban-Perez, J., Garcia-Redondo, A., Al-Chalabi, A., Al Kheifat, A., Andersen, P. M., Chio, A., Cooper-Knock, J., Dekker, A., Redondo, A. G., Gotkine, M., Hide, W., Iacoangeli, A., Kiernan, M., Landers, J. E., Mill, J., Neto, M. M., Pardina, J. M., Newhouse, S., Pinto, S., Pulit, S., Robberecht, W., Shaw, C., Sproviero, W., Tazelaar, G., Van Damme, P., van den Berg, L. H., van Vugt, J., Veldink, J. H., Zatz, M., Bauer, D. C., Twine, N. A., Rogaeva, E., Zinman, L., Brice, A., Feldman, E. L., Ludolph, A. C., Weishaupt, J. H., Trojanowski, J. Q., Stone, D. J., Tienari, P., Shaw, C. E., Traynor, B. J., Marangi G. (ORCID:0000-0002-6898-8882), Logroscino G. (ORCID:0000-0003-1301-5343), Capasso M., Mosca L. (ORCID:0000-0003-4641-0841), Fasano A., Sabatelli M. (ORCID:0000-0001-6635-4985), Zollino M. (ORCID:0000-0003-4871-9519), Conte A., Luigetti M. (ORCID:0000-0001-7539-505X), Lattante S. (ORCID:0000-0003-2891-0340), D'Alfonso S., Siciliano G., Valori M., and Landi F. (ORCID:0000-0002-3472-1389)
- Abstract
To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS. Using a large-scale genome-wide association study and exome sequencing, we identified KIF5A as a novel gene associated with ALS. Our data broaden the phenotype resulting from mutations in KIF5A and highlight the importance of cytoskeletal defects in the pathogenesis of ALS.
- Published
- 2018
33. Lithium ion insertion in porous metal oxides
- Author
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Owens, Boone B, Passerini, Stefano, and Smyrl, William H
- Published
- 1999
- Full Text
- View/download PDF
34. Solid State Primary Batteries
- Author
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Owens, Boone B., Sequeira, C. A. C., editor, and Hooper, A., editor
- Published
- 1985
- Full Text
- View/download PDF
35. Competitive Systems - Primary Batteries
- Author
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Owens, Boone B., Sequeira, C. A. C., editor, and Hooper, A., editor
- Published
- 1985
- Full Text
- View/download PDF
36. Ionic conductivity of a poly(vinylpyridinium)/silver iodide solid polymer electrolyte system
- Author
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William H. Smyrl, Wesley A. Henderson, Boone B. Owens, Ted M. Pappenfus, and Kent R. Mann
- Subjects
chemistry.chemical_classification ,Materials science ,Inorganic chemistry ,Silver iodide ,General Chemistry ,Polymer ,Activation energy ,Electrolyte ,Conductivity ,Condensed Matter Physics ,Amorphous solid ,chemistry.chemical_compound ,Differential scanning calorimetry ,chemistry ,Ionic conductivity ,General Materials Science - Abstract
A series of quaternized poly(2-vinylpyridine) (PVP) polymers has been synthesized with the general formula [(PVP) R ]I, where R =H, Me, Bu. Addition of AgI to the polymers results in new silver ion conducting solid polymer materials. Conductivities as high as 6×10 −3 S/cm have been observed for the 3:1 AgI/[(PVP)Me]I composition. Analogous materials with a 3:1 composition for the protonated and butyl-substituted polymers display lower conductivities near 2×10 −4 S/cm. Conductivity studies, as a function of temperature, show these materials to be thermodynamically stable with a low activation energy for ion conduction. Differential scanning calorimetry experiments suggest that a new phase with the general formula (PVP) R Ag 3 I 4 forms with silver ions in a new amorphous state.
- Published
- 2004
- Full Text
- View/download PDF
37. Thin Film Electrochemical Power Cells
- Author
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Owens, Boone B., primary and Smyrl, William H., primary
- Published
- 1991
- Full Text
- View/download PDF
38. Electrochemical and synchrotron XAS studies of lithium intercalation into vanadium pentoxide aerogels and nanocomposites
- Author
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Matthew M. Fay, F. Coustier, Stefano Passerini, William H. Smyrl, Boone B. Owens, and Marco Giorgetti
- Subjects
X-ray absorption spectroscopy ,Materials science ,Absorption spectroscopy ,Renewable Energy, Sustainability and the Environment ,Inorganic chemistry ,Intercalation (chemistry) ,Energy Engineering and Power Technology ,Vanadium ,chemistry.chemical_element ,XANES ,Vanadium oxide ,chemistry ,Oxidation state ,Pentoxide ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry - Abstract
Vanadium pentoxide aerogels are pillared nanocomposites with exceptional stability, intercalation capacity, and reversibility. X-ray absorption spectroscopy (XAS) measurements on pristine and doped materials have revealed details of the oxidation state and local structure of the host material and of the polyvalent doping species. XANES measurements at the Cu K-edge for Cu 0.1 V 2 O 5 show the atomic level reversibility of the structure upon Li + insertion/release cycling.
- Published
- 2001
- Full Text
- View/download PDF
39. Medical batteries for external medical devices
- Author
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Boone B. Owens and Stefano Passerini
- Subjects
Battery (electricity) ,Materials science ,Renewable Energy, Sustainability and the Environment ,business.industry ,Pulse discharge ,Pulse (signal processing) ,Electrical engineering ,Energy Engineering and Power Technology ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,business - Abstract
A miniature 10 mAh, 3.75 V Li-ion battery (button cell) has been developed for external medical application. The miniature cells (0.2 cm 3 ) show excellent performance in terms of cycle life, energy and power. Life tests have exceeded 2700 cycles at 60% DOD and discharge rates of 1–3 mA. Full discharge tests (100% DOD) have shown very good performance with more than 90% of the capacity delivered at the C -rate. Pulse discharge tests indicated excellent pulse capabilities of up to 100 mA over low-level background currents of 10–100 μA.
- Published
- 2001
- Full Text
- View/download PDF
40. Lithium-ion batteries for hearing aid applications
- Author
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F. Coustier, Boone B. Owens, and Stefano Passerini
- Subjects
Battery (electricity) ,Hearing aid ,Engineering ,Renewable Energy, Sustainability and the Environment ,business.industry ,medicine.medical_treatment ,Electrical engineering ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Electrochemical cell ,Cell size ,chemistry ,Pulse discharge ,medicine ,Lithium ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,Ac impedance ,business ,Electrical impedance - Abstract
Rechargeable lithium-ion batteries were designed to meet the power requirements of hearing aid devices (HADs). The batteries were designed in a 312-button cell size, compatible with existing hearing aids. The batteries were tested to evaluate the design and the electrochemical performance, as they relate to a typical hearing aid application. The present report covers the pulse capabilities, cycle life and preliminary safety tests. The results are compared with other battery chemistries: secondary lithium-alloy and nickel–metal hydride batteries and primary Zn–air batteries. The cell AC impedance was stable over the frequency range between 1 and 50 kHz, ranging between 5 Ω at the higher frequency and 12 Ω at the lower extreme. Pulse tests were consistent with these values, as the cells were capable of providing a series of 100 mA pulses of 10-s duration. The safety tests suggest that the design is intrinsically safe with respect to the most common types of abuse conditions.
- Published
- 2000
- Full Text
- View/download PDF
41. Solid state electrolytes: overview of materials and applications during the last third of the Twentieth Century
- Author
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Boone B. Owens
- Subjects
Renewable Energy, Sustainability and the Environment ,Chemistry ,Silver sulfide ,Solid-state ,Energy Engineering and Power Technology ,Mineralogy ,Ionic bonding ,Conductivity ,Solid state electrolyte ,law.invention ,Solid state ionics ,chemistry.chemical_compound ,Chemical engineering ,law ,Fast ion conductor ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,Faraday cage - Abstract
Solid state ionics has been a very active field of science during the last third of the century. However, the first observations of conductivity in solid electrolytes occurred over 150 years ago. Faraday reported the transport of silver ions through silver sulfide in 1834. The present report describes some of the more recent investigations of solid state ionic materials and devices, with emphasis on room temperature materials and solid state batteries. Prof. Osamu Yamamoto and his colleagues discovered the most conductive room temperature solid ionic material that is known up to the present time. This compound is Rb 4 Cu 16 I 7 Cl 13 with a specific conductivity of 0.34 S/cm at 25°C.
- Published
- 2000
- Full Text
- View/download PDF
42. Lithium-ion batteries for hearing aid applications: I. Design and performance
- Author
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Stefano Passerini, F. Coustier, and Boone B. Owens
- Subjects
Hearing aid ,Battery (electricity) ,Engineering ,Renewable Energy, Sustainability and the Environment ,business.industry ,medicine.medical_treatment ,Electrical engineering ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Charge voltage ,chemistry ,medicine ,Lithium ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,Engineering design process ,business - Abstract
Rechargeable batteries have been designed for powering hearing aid devices (HAD). The cells, based on the lithium-ion chemistry, were designed in a size that is compatible with the existing HAD. The 10 mA h batteries were tested to characterize the design and the electrochemical performance from the point of view of a typical HAD application. Results are presented for constant-current tests, first-cycle conditions, charge voltage cut-off, rate performance, and cycle life. The pulse capabilities and the preliminary safety tests of the batteries will be presented in a following report. The results of the lithium-ion HAD cells developed in this project are compared with other battery chemistries: lithium-alloy and nickel–metal hydride secondary batteries and Zn–air primary batteries.
- Published
- 2000
- Full Text
- View/download PDF
43. Lithium ion insertion in porous metal oxides
- Author
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William H. Smyrl, Boone B. Owens, and Stefano Passerini
- Subjects
Lithium vanadium phosphate battery ,General Chemical Engineering ,Inorganic chemistry ,Oxide ,chemistry.chemical_element ,Vanadium ,Vanadium oxide ,Amorphous solid ,chemistry.chemical_compound ,chemistry ,Transition metal ,Electrochemistry ,Lithium ,Sol-gel - Abstract
Sol–gel processing of transition metal oxide precursors has been used to produce porous materials of high surface area. The technique has permitted the synthesis of solid amorphous vanadium and manganese oxides that are capable of reversibly intercalating large amounts of lithium ions. Therefore, these materials may function as high capacity (500–600 mAh/g), high-energy positive electrodes in lithium batteries. Methods to improve the kinetics and the cycle performance of these positive electrodes are showing promise.
- Published
- 1999
- Full Text
- View/download PDF
44. R&D on lithium batteries in the USA: high-energy electrode materials
- Author
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Boone B. Owens, Jun John Xu, and William H. Smyrl
- Subjects
Battery (electricity) ,Lithium vanadium phosphate battery ,Renewable Energy, Sustainability and the Environment ,Inorganic chemistry ,Energy Engineering and Power Technology ,Vanadium ,chemistry.chemical_element ,Nanotechnology ,Electrolyte ,Cathode ,Lithium battery ,law.invention ,chemistry ,law ,Electrode ,Lithium ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry - Abstract
Recent trends in R&D on lithium battery technology in the USA continue to focus on high-performance batteries, polymer electrolyte systems and the development and production of batteries for specialty markets. Research on sol–gel derived amorphous vanadium and manganese oxides as high capacity, high-energy electrode materials has shown these morphologies are capable of reversibly intercalating very large amounts of lithium and they are attractive cathode candidates. Methods to improve the kinetics of these positive electrodes are showing promise.
- Published
- 1999
- Full Text
- View/download PDF
45. Doped Vanadium Oxides as Host Materials for Lithium Intercalation
- Author
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F. Coustier, Stefano Passerini, William H. Smyrl, Boone B. Owens, and Jason Hill
- Subjects
inorganic chemicals ,Materials science ,Lithium vanadium phosphate battery ,Renewable Energy, Sustainability and the Environment ,Doping ,Inorganic chemistry ,technology, industry, and agriculture ,Vanadium ,chemistry.chemical_element ,social sciences ,Condensed Matter Physics ,Mole fraction ,Electrochemistry ,Copper ,Vanadium oxide ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,Materials Chemistry ,lipids (amino acids, peptides, and proteins) ,Lithium ,human activities - Abstract
An improved cathodic material has been obtained by doping vanadium oxide hydrogel with silver. Silver-doped vanadium pentoxides with a silver molar fraction ranging from 0.01 to 1 were synthesized. With the successful doping, the electronic conductivity of V{sub 2}O{sub 5} was increased by 2 to 3 orders of magnitude. The electrochemical performance of the silver doped materials is very high, up to 4 moles of lithium per mole of silver-doped V{sub 2}O{sub 5} were found to be reversibly intercalated. In addition, the lithium diffusion coefficient is found to be high in the silver-doped material and with a smaller dependence on the lithium intercalation level. These enhancements resulted in high rates of insertion and delivered capacities.
- Published
- 1999
- Full Text
- View/download PDF
46. Composites of V 2 O 5 Aerogel and Nickel Fiber as High Rate Intercalation Electrodes
- Author
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Boone B. Owens, William H. Smyrl, Stefano Passerini, and M. J. Parent
- Subjects
Materials science ,Renewable Energy, Sustainability and the Environment ,Diffusion ,Intercalation (chemistry) ,chemistry.chemical_element ,Vanadium ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Amorphous solid ,Nickel ,chemistry ,Materials Chemistry ,Electrochemistry ,Pentoxide ,Lithium ,Cyclic voltammetry ,Composite material - Abstract
Amorphous vanadium pentoxide (V{sub 2}O{sub 5}) has been investigated as an intercalation material for Li-ion batteries due to its high specific energy and high capacity for Li intercalation. However, the rate of insertion is typically limited by lithium diffusion in the host and by its modest conductivity. The present work demonstrates that high intercalation rates are possible if the host microstructure is modified to decrease the characteristic lithium diffusion distance and the characteristic conduction distance. Thin films of V{sub 2}O{sub 5} were grown by preferential gelation on sintered nickel fibers via a sol-gel route. Electrochemical impedance measurements of the composite electrodes indicated that diffusion limitations in the host were successfully avoided. Constant current cycling and cyclic voltammetry were also used to characterize the composites. Specific powers, based on mass of active material, of almost 6 MW/kg were observed.
- Published
- 1999
- Full Text
- View/download PDF
47. High rate electrodes of V2O5 aerogel
- Author
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Boone B. Owens, J. J. Ressler, D. B. Le, William H. Smyrl, and Stefano Passerini
- Subjects
Materials science ,General Chemical Engineering ,Composite number ,Intercalation (chemistry) ,Vanadium ,chemistry.chemical_element ,Aerogel ,Nanotechnology ,Substrate (electronics) ,Electrochemistry ,chemistry ,Electrode ,Pentoxide ,Composite material - Abstract
In the present paper we report on high rate electrodes made from a conventional battery cathode material, vanadium pentoxide. The electrodes were obtained through a sol–gel process by which the active materials were coated in the form of thin, highly porous, layers on appropriate conducting substrates. The composite electrodes are characterized by very short ionic and electronic paths throughout the intercalation compound. Aerogel films deposited on a Hastelloy felt substrate had specific surface areas of 40 m2/g with pores of 20–200 nm diameter and wall thicknesses of 10–20 nm. Electrochemical impedance analysis revealed the expected response for intercalation, except that there was no Warburg (diffusion) component. The latter demonstrates that we successfully eliminated one of the primary limitations of intercalation materials, i.e. diffusion in the solid phase, by the design of the composite electrodes.
- Published
- 1999
- Full Text
- View/download PDF
48. Silver solid-state batteries: A 33 years storage realities
- Author
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Bruno Scrosati, Priscilla Reale, and Boone B. Owens
- Subjects
Battery (electricity) ,batteries ,business.industry ,Chemistry ,Solid-state ,Mineralogy ,Internal resistance ,reference ,Shelf life ,solid-state ,lcsh:Chemistry ,silver ,storage ,lcsh:Industrial electrochemistry ,lcsh:QD1-999 ,Available energy ,Electrochemistry ,Process engineering ,business ,lcsh:TP250-261 - Abstract
Solid-state, Ag/Me4NIn (n = 5 or 9) batteries have been tested in terms of changes of open circuit voltage, internal resistance and constant-load discharge curves after a storage time of 33 years at 23 °C. The results are in agreement the original shelf life projections, this confirming that these solid-state batteries should survive 50 years storage at 20–25 °C, and still deliver 50–60% of the initial available energy. To our knowledge, such an exceptional shelf life is an unique feature in the battery scenario which gives to these solid-state systems a renewed interest as reliable, long-life reference systems. Keywords: Batteries, Solid-state, Silver, Storage, Reference
- Published
- 2007
- Full Text
- View/download PDF
49. Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1
- Author
-
Boddu, R, Yang, CZ, O'Connor, AK, Hendrickson, RC, Boone, B, Cui, XQ, García González , Miguel Ángel, Igarashi, P, Onuchic, LF, Germino, GG, and Guay-Woodford, LM
- Subjects
Alternative Splicing ,Transcription, Genetic ,Mice, Inbred DBA ,Reverse Transcriptase Polymerase Chain Reaction ,Sequence Analysis, RNA ,Mutagenesis, Site-Directed ,Animals ,Genetic Variation ,Humans ,Receptors, Cell Surface ,Exons ,RNA, Messenger ,Kidney - Abstract
Autosomal recessive polycystic kidney disease (ARPKD) results from mutations in the human PKHD1 gene. Both this gene, and its mouse ortholog, Pkhd1, are primarily expressed in renal and biliary ductal structures. The mouse protein product, fibrocystin/polyductin complex (FPC), is a 445-kDa protein encoded by a 67-exon transcript that spans >500 kb of genomic DNA. In the current study, we observed multiple alternatively spliced Pkhd1 transcripts that varied in size and exon composition in embryonic mouse kidney, liver, and placenta samples, as well as among adult mouse pancreas, brain, heart, lung, testes, liver, and kidney. Using reverse transcription PCR and RNASeq, we identified 22 novel Pkhd1 kidney transcripts with unique exon junctions. Various mechanisms of alternative splicing were observed, including exon skipping, use of alternate acceptor/donor splice sites, and inclusion of novel exons. Bioinformatic analyses identified, and exon-trapping minigene experiments validated, consensus binding sites for serine/arginine-rich proteins that modulate alternative splicing. Using site-directed mutagenesis, we examined the functional importance of selected splice enhancers. In addition, we demonstrated that many of the novel transcripts were polysome bound, thus likely translated. Finally, we determined that the human PKHD1 R760H missense variant alters a splice enhancer motif that disrupts exon splicing in vitro and is predicted to truncate the protein. Taken together, these data provide evidence of the complex transcriptional regulation of Pkhd1/PKHD1 and identified motifs that regulate its splicing. Our studies indicate that Pkhd1/PKHD1 transcription is modulated, in part by intragenic factors, suggesting that aberrant PKHD1 splicing represents an unappreciated pathogenic mechanism in ARPKD. Key messages: Multiple mRNA transcripts are generated for Pkhd1 in renal tissues Pkhd1 transcription is modulated by standard splice elements and effectors Mutations in splice motifs may alter splicing to generate nonfunctional peptides.
- Published
- 2014
50. Panel discussion future prospects of lithium batteries
- Author
-
Tetsuya Osaka and Boone B. Owens
- Subjects
Materials science ,chemistry ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Lithium ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,Engineering physics ,Panel discussion - Published
- 1997
- Full Text
- View/download PDF
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