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13 results on '"Boone, Laura I."'

1. Contributors

Author

Agca, Yuksel, primary, Alejandro, Emilyn U., additional, Allen, Portia S., additional, Allen, Kenneth P., additional, Allen–Worthington, Krystal, additional, Arndt, Tara P., additional, Baker, Henry J., additional, Bergin, Ingrid L., additional, Boone, Laura I., additional, Booth, Jennifer, additional, Borjeson, Tiffany Marie, additional, Boschen, Suelen Lucio, additional, Browne, Kevin D., additional, Budelsky, Carl L., additional, Cadillac, Joan M., additional, Carter, Philip B., additional, Compton, Susan R., additional, Conte, Marisa L., additional, Crisler, Robin, additional, Cullen, D. Kacy, additional, De la Vega, Rodolfo E., additional, Dell’Italia, Louis J., additional, Drake, Michael T., additional, Duke Boynton, Felicia, additional, Dunbar, Misha, additional, Dwinell, Melinda R., additional, El-Ayache, Nadine, additional, Esvelt, Marian, additional, Evans, Christopher H., additional, Faith, Robert E., additional, Foley, Patricia L., additional, Galligan, James J., additional, Geurts, Aron M., additional, Golledge, Huw DR., additional, Hanson, Marina M., additional, Hashway, Sara A., additional, Hedrich, Hans J., additional, Herbert, Ronald A., additional, Herfel, Tina Marie, additional, Hessler, Jack R., additional, Hickey, Raymond D., additional, Jaber, Samer M., additional, Janardhan, Kyathanahalli S., additional, Johnston, Nancy A., additional, King-Herbert, Angela P., additional, King-Herbert, Angela, additional, King, William W., additional, Koewler, Nathan, additional, Kohn, Dennis F., additional, Kolb, Bryan, additional, Kotz, Catherine M., additional, Lockridge, Amber D., additional, Lofgren, Jennifer LS., additional, Lohmiller, Jeffrey J., additional, Macy, James D., additional, Makidon, Paul E., additional, Meade, Theresa M., additional, Mexas, Angela M., additional, Mickelson, Barbara, additional, Wilson, Jolaine M., additional, Myers, Daniel D., additional, Myles, Matthew H., additional, Norin, Elisabeth, additional, Otto, Glen M., additional, Patil, Karuna, additional, Perez-Leighton, Claudio E., additional, Philips, Blythe H., additional, Ramos, Carlos Cuellar, additional, Scholz, Jodi A., additional, Sebastian, Manu M., additional, Shoulson, Rivka L., additional, Sivula, Christine, additional, Slate, Andrea R., additional, Suckow, Mark A., additional, Swennes, Alton G., additional, Swing, Sonya P., additional, Teske, Jennifer A., additional, Tunstall, Brendan J., additional, VanLith, Caitlin J., additional, Vasbinder, Mary Ann, additional, Vendruscolo, Leandro F., additional, Watson, Julie, additional, Weisbroth, Steven H., additional, Whishaw, Ian Q., additional, Wilding, Laura A., additional, and Wilson, Ronald P., additional

Published
2020
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6. Contributors

Author

Akucewich, Lisa, primary, Andrew, Stacy E., additional, Andrews, Dina A., additional, Bartges, Joseph W., additional, Beal, Matthew W., additional, Beale, Brian S., additional, Bebchuk, Trevor N., additional, Bellah, Jamie R., additional, Bergman, Philip J., additional, Bonagura, John D., additional, Boncyznski, Jennifer S., additional, Boone, Laura I., additional, Boothe, Harry W., additional, Boyd, Lauren, additional, Bright, Ronald M., additional, Calpin, Janet, additional, Chew, Dennis J., additional, Coates, Joan R., additional, Cohn, Leah A., additional, Cole, Lynette K., additional, Colitz, Carmen M.H., additional, Crowell-Davis, Sharon L., additional, Davidson, Harriet J., additional, Dillon, Ray, additional, Dunayer, Eric K., additional, Durocher, Lawren L., additional, Fowler, J. David, additional, Garosi, Laurent, additional, Gelzer, Anna R.M., additional, Ghubash, Rudayna M., additional, Greco, Deborah S., additional, Greene, Craig E., additional, Greer, Rebecca J., additional, Gruenenfelder, Fredrik, additional, Guptill, Lynn, additional, Gwaltney-Brant, Sharon M., additional, Häggström, Jens, additional, Harkin, Kenneth, additional, Henson, Kristin L., additional, Herring, Ian P., additional, Hess, Milan B., additional, Hess, Rebecka S., additional, Heuter, Kerry J., additional, Hill, Kate E., additional, Hitt, Mark E., additional, Howe, Lisa M., additional, Hume, Daniel Z., additional, Irizarry-Rovira, Armando R., additional, Johnson, Lynelle R., additional, Kelmer, Efrat, additional, Kennis, Robert A., additional, Kent, Marc, additional, Kerl, Marie E., additional, Kirk, Claudia A., additional, Kowaleski, Michael P., additional, Kraus, Marc S., additional, Langdon, Paige, additional, Langley-Hobbs, Sorrel, additional, Langston, Cathy E., additional, Lappin, Michael, additional, Larocca, Robert D., additional, Lauten, Susan D., additional, Lemarie, Stephen L., additional, Lieske, Camilla, additional, Logan, Ellen I., additional, Logas, Dawn E., additional, Looney, Andrea L., additional, Lothrop, Clinton D., additional, Ludwig, Lori L., additional, Lurye, Jill, additional, MacDonald, Kristin, additional, Madden, Stacey Nicoll, additional, Mann, F.A., additional, Marlar, Annajane B., additional, Marrion, Ruth, additional, Marsella, Rosanna, additional, Means, Charlotte, additional, Mensching, Donna, additional, Merola, Valentina, additional, Miller, Ellen, additional, Miller, Rita H., additional, Moore, Lisa E., additional, Morgan, Rhea V., additional, Mughannam, Albert J., additional, Munger, Robert J., additional, Muse, Russell, additional, Nelson, O. Lynne, additional, Nielsen, Astrid, additional, Paradis, Manon, additional, Parnell, Nolie K., additional, Platt, Simon R., additional, Podell, Michael, additional, Pope, Eric R., additional, Prittie, Jennifer E., additional, Prymak, Caroline, additional, Raskin, Rose E., additional, Reine, Nyssa J., additional, Reniker, Alisa N., additional, Ring, Rachel D., additional, Kustritz, Margaret V. Root, additional, Rothstein, Emily, additional, Rozear, Lance, additional, Ruaux, Craig G., additional, Schatzberg, Scott J., additional, Schmidt, Bradley R., additional, Schultze, A. Eric, additional, Scott, Michael A., additional, Smarick, Sean, additional, Smith, Stephanie A., additional, Soiderer, Emily, additional, Solano-Gallego, Laia, additional, Sousa, Candace A., additional, Spangler, William L., additional, Spier, Alan, additional, Stuhr, Charles M., additional, Swinney, Graham, additional, Taboada, Joseph, additional, Taylor, Robert A., additional, Taylor, Susan M., additional, Thomas, Jennifer S., additional, Tobias, Anthony H., additional, Trout, Nicholas J., additional, Volmer, Petra A., additional, Ward, Cynthia R., additional, Wardrop, K. Jane, additional, White, Robert N., additional, Williamson, Nicola, additional, Willis, A. Michelle, additional, Wood, Emilia F., additional, and Zoran, Debra L., additional

Published
2008
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8. Current Practices and Challenges in Method Validation.

Author

Poitout, Florence, Colangelo, Jennifer L., Lavallée, Simon, Aulbach, Adam D., Piché, Marie-Soleil, Ennulat, Daniela, Ameri, Mehrdad, and Boone, Laura I.

Subjects
CLINICAL pathology, BIOLOGICAL tags
Abstract

Method validation is a cornerstone on which biomarker development and utilization rest. However, given the abundance of biomarker candidates that are being identified and characterized, validation of these entities for the use in nonclinical studies can be complex. The objective of this continuing education course was to review current practices and challenges encountered during the validation of methods for the analysis of novel biomarkers. Additionally, the importance of biological validation and correlation with pathology end points for biomarker candidates was discussed. This article is a summary of the materials presented at the 36th Annual Symposium of the Society of Toxicologic Pathology for a continuing education course titled “Current Practices and Challenges in Method Validation.” The speakers were subject-matter experts in the validation of quantitative mass spectrometry, multiplex binding assays, biological biomarkers, and immunophenotyping and anatomic and clinical pathology considerations in biomarker qualification. [ABSTRACT FROM AUTHOR]

Published
2018
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10. P4-358 In vitro and in vivo characterization of beta-amyloid antibodies binding to cerebral amyloid angiopathy (CAA) and the selective exacerbation of CAA-associated microhemorrhage

Author

DeMattos, Ronald B., primary, Boone, Laura I., additional, Hepburn, Deena L., additional, Parsadanian, Maia, additional, Bryan, Matthew T., additional, Ness, Daniel K., additional, Piroozi, Kathy S., additional, Holtzman, David M., additional, Bales, Kelly R., additional, Gitter, Bruce D., additional, Paul, Steven M., additional, and Racke, Margaret, additional

Published
2004
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13. Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β.

Author

Racke, Margaret M., Boone, Laura I., Hepburn, Deena L., Parsadainian, Maia, Bryan, Matthew T., Ness, Daniel K., Piroozi, Kathy, Jordan, William H., Brown, Donna D., Hoffman, Wherly P., Holtzman, David M., Bales, Kelly R., Gitter, Bruce D., May, Patrick C., Paul, Steven M., and DeMattos, Ronald B.

Subjects
*AMYLOID, *ALZHEIMER'S disease, *ANIMAL models in research, *IMMUNOGLOBULINS, *IMMUNOTHERAPY
Abstract

Passive immunization with an antibody directed against the N terminus of amyloid β (Aβ) has recently been reported to exacerbate cerebral amyloid angiopathy (CAA)-related microhemorrhage in a transgenic animal model. Although the mechanism responsible for the deleterious interaction is unclear, a direct binding event may be required. We characterized the binding properties of several monoclonal anti-Aβ antibodies to deposited Aβ in brain parenchyma and CAA. Biochemical analyses demonstrated that the 3D6 and 10D5, two N-terminally directed antibodies, bound with high affinity to deposited forms of A β, whereas 266, a central domain antibody, lacked affinity for deposited Aβ. To determine whether 266 or 3D6 would exacerbate CAA-associated microhemorrhage, we treated aged PDAPP mice with either antibody for 6 weeks. We observed an increase in both the incidence and severity of CAA- associated microhemorrhage when PDAPP transgenic mice were treated with the N-terminally directed 3D6 antibody, whereas mice treated with 266 were unaffected. These results may have important implications for future immune-based therapeutic strategies for Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2005
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