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1. Multiscale experimental study of H\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_2$$\end{document}/brine multiphase flow in porous rock characterizing relative permeability hysteresis, hydrogen dissolution, and Ostwald ripening

Author

Boon, Maartje, Rademaker, Tim, Winardhi, Chandra Widyananda, and Hajibeygi, Hadi

Published
2024
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5. Multiscale experimental study of H/brine multiphase flow in porous rock characterizing relative permeability hysteresis, hydrogen dissolution, and Ostwald ripening.

Author

Boon, Maartje, Rademaker, Tim, Winardhi, Chandra Widyananda, and Hajibeygi, Hadi

Abstract

To safely and efficiently utilize porous reservoirs for underground hydrogen storage (UHS), it is essential to characterize hydrogen transport properties at multiple scales. In this study, hydrogen/brine multiphase flow at 50 bar and 25 °C in a 17 cm Berea sandstone rock core was characterized and visualized at the pore and core scales using micro X-ray CT. The experiment included a single drainage and imbibition cycle during which relative permeability hysteresis was measured, and two no-flow periods to study the redistribution of hydrogen in the pore space during storage periods. An end-point relative permeability of 0.043 was found at , and the residual gas saturation was measured to be 0.32. Despite extensive pre-equilibration, significant dissolution of hydrogen into brine occurred near the core inlet due to elevated pressures and the corresponding increase in hydrogen solubility. During drainage, many disconnected hydrogen ganglia were observed further down the core which could be explained by the exsolution of the dissolved hydrogen. During imbibition, the dissolution of hydrogen led to the formation of preferential flow paths near the inlet, and eventually removed most of the trapped hydrogen in the final stage of the experiment. The two no-flow periods were characterized by the fragmentation of medium-sized hydrogen ganglia and the growth of a few larger ganglia, providing evidence for hydrogen re-connection through the dissolution-driven process of Ostwald ripening. These results demonstrate that despite the low solubility of hydrogen in brine, hydrogen dissolution can significantly influence the observed multiphase flow and trapping behavior in the reservoir and should be considered in UHS modeling. [ABSTRACT FROM AUTHOR]

Published
2024
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9. The impact of rock heterogeneity on solute spreading and mixing

Author

Boon, Maartje, Krevor, Samuel, and Bijeljic, Branko

Subjects
552
Abstract

In this thesis we have performed an experimental investigation on the impact of rock heterogeneity on solute spreading and mixing in porous rock using X-ray tomography. Furthermore, we have created a numerical model based on experimentally obtained statistical rock descriptions to investigate the impact of transport and chemical heterogeneity on reactive transport. We present a new core-flood test to characterize solute transport in 3-D natural-rock media. The test is carried out for three rocks with an increasing level of heterogeneity: Berea sandstone, Ketton carbonate and Indiana carbonate. The impact of heterogeneity on solute transport is analysed by: 1., quantifying spreading and mixing using metrics such as the transverse dispersion coefficient, the dilution index, and the scalar dissipation rate, and 2., visualizing and analysing flow structures such as meandering, flow-focusing and flow-splitting. The transverse dispersion coefficient, Dt, and the variation in Dt throughout the rock core, increases with Peclet number (Pe) and rock heterogeneity. The dilution index and scalar dissipation rate indicate that mixing is Fickian for the Berea sandstone and Ketton carbonate, but diverges for the Indiana carbonate. Heterogeneous rock features are observed to cause meandering, focusing or splitting of the plume depending on Pe. The impact of transport and chemical heterogeneity on reactive transport is investigated by modelling the injection of a HCl solution into the three rocks. The model shows that both transport and chemical heterogeneity are important and the dominating factor depends on the transport regime and reaction kinetics. The model is able to capture different dissolution regimes: compact dissolution is observed for low injection rates while the onset of wormholing and uniform dissolution is observed for the higher injection rates. The modelling results are a first indication that statistical descriptions of transport and chemical heterogeneity can improve continuum scale reactive transport modelling.

Published
2017
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21. Prognostic factors for relapse and outcome in pediatric acute transverse myelitis

Author

Helfferich, Jelte, Bruijstens, Arlette L., Wong, Yu Yi M., Danielle van Pelt, E., Boon, Maartje, Neuteboom, Rinze F., Bakker, D. P., Braun, K. P.J., van Dijk, K. G.J., Eikelenboom, M. J., Engelen, M., Brandsma, R., Haaxma, C. A., Niermeijer, J. M.F., Niks, E. H., Peeters, E. A.J., Peeters-Scholte, C. M.P.C.D., Portier, R. P., de Rijk-van Andel, J. F., Samijn, J. P.A., Schippers, H. M., Sie, L. T.L., Snoeck, I. N., Vermeulen, R. J., Verrips, A., Visscher, F., Willemsen, M. A.A.P., Catsman-Berrevoets, C. E., Helfferich, Jelte, Bruijstens, Arlette L., Wong, Yu Yi M., Danielle van Pelt, E., Boon, Maartje, Neuteboom, Rinze F., Bakker, D. P., Braun, K. P.J., van Dijk, K. G.J., Eikelenboom, M. J., Engelen, M., Brandsma, R., Haaxma, C. A., Niermeijer, J. M.F., Niks, E. H., Peeters, E. A.J., Peeters-Scholte, C. M.P.C.D., Portier, R. P., de Rijk-van Andel, J. F., Samijn, J. P.A., Schippers, H. M., Sie, L. T.L., Snoeck, I. N., Vermeulen, R. J., Verrips, A., Visscher, F., Willemsen, M. A.A.P., and Catsman-Berrevoets, C. E.

Abstract

Objective: It may be difficult for clinicians to estimate the prognosis of pediatric acute transverse myelitis (ATM). The aim of this study was to define prognostic factors for relapsing disease and poor outcome in pediatric ATM. Methods: This prospective cohort study included 49 children, 18 boys and 31 girls (median age 13.1 years, IQR 6.5–16.2) with a first episode of ATM. Factors associated with relapsing disease and poor outcome (Expanded Disability Status Scale (EDSS) ≥ 4) were assessed during a median follow-up of 37 months (IQR 18–75). Results: In total, 14 patients (29%) experienced ≥ 1 relapse(s) and nine patients (18%) had a poor outcome. Factors at onset associated with relapsing disease included higher age (16.1 vs. 11.6 years, p = 0.002), longer time to maximum severity of symptoms (5.5 vs. 3 days, p = 0.01), lower maximum EDSS score (4.0 vs. 6.5, p = 0.003), short lesion on spinal MRI (64 vs. 21%, p = 0.006), abnormalities on brain MRI (93 vs. 44%, p = 0.002) and presence of oligoclonal bands in cerebrospinal fluid (67 vs. 14%, p = 0.004). The only factor associated with poor outcome was presence of a spinal cord lesion on MRI without cervical involvement (56 vs. 14%, p = 0.02). Conclusion: Pediatric ATM patients presenting with clinical, radiological and laboratory features associated with multiple sclerosis (MS) are at risk for relapsing disease. In absence of these known MS risk factors at onset of disease these patients are at low risk for relapses. Only a minority of pediatric ATM patients in this cohort have a poor outcome.

Published
2021

22. Prognostic factors for relapse and outcome in pediatric acute transverse myelitis

Author

Neurologen, Brain, Helfferich, Jelte, Bruijstens, Arlette L., Wong, Yu Yi M., Danielle van Pelt, E., Boon, Maartje, Neuteboom, Rinze F., Bakker, D. P., Braun, K. P.J., van Dijk, K. G.J., Eikelenboom, M. J., Engelen, M., Brandsma, R., Haaxma, C. A., Niermeijer, J. M.F., Niks, E. H., Peeters, E. A.J., Peeters-Scholte, C. M.P.C.D., Portier, R. P., de Rijk-van Andel, J. F., Samijn, J. P.A., Schippers, H. M., Sie, L. T.L., Snoeck, I. N., Vermeulen, R. J., Verrips, A., Visscher, F., Willemsen, M. A.A.P., Catsman-Berrevoets, C. E., Neurologen, Brain, Helfferich, Jelte, Bruijstens, Arlette L., Wong, Yu Yi M., Danielle van Pelt, E., Boon, Maartje, Neuteboom, Rinze F., Bakker, D. P., Braun, K. P.J., van Dijk, K. G.J., Eikelenboom, M. J., Engelen, M., Brandsma, R., Haaxma, C. A., Niermeijer, J. M.F., Niks, E. H., Peeters, E. A.J., Peeters-Scholte, C. M.P.C.D., Portier, R. P., de Rijk-van Andel, J. F., Samijn, J. P.A., Schippers, H. M., Sie, L. T.L., Snoeck, I. N., Vermeulen, R. J., Verrips, A., Visscher, F., Willemsen, M. A.A.P., and Catsman-Berrevoets, C. E.

Published
2021

24. Prognostic factors for relapse and outcome in pediatric acute transverse myelitis

Author

Helfferich, Jelte, primary, Bruijstens, Arlette L., additional, Wong, Yu Yi M., additional, Danielle van Pelt, E., additional, Boon, Maartje, additional, Neuteboom, Rinze F., additional, Bakker, D.P., additional, Braun, K.P.J., additional, van Dijk, K.G.J., additional, Eikelenboom, M.J., additional, Engelen, M., additional, Brandsma, R., additional, Haaxma, C.A., additional, Niermeijer, J.M.F., additional, Niks, E.H., additional, Peeters, E.A.J., additional, Peeters-Scholte, C.M.P.C.D., additional, Portier, R.P., additional, de Rijk-van Andel, J.F., additional, Samijn, J.P.A., additional, Schippers, H.M., additional, Sie, L.T.L., additional, Snoeck, I.N., additional, Vermeulen, R.J., additional, Verrips, A., additional, Visscher, F., additional, Willemsen, M.A.A.P., additional, and Catsman-Berrevoets, C.E., additional

Published
2021
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40. Erratum to: Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach

Author

Genetica Klinische Genetica, ZL Kinder Ner en Nec Medisch, Brain, Apotheek Klinische Farmacie, Klinische zorg, Other research (not in main researchprogram), Child Health, Genetica Sectie Genoomdiagnostiek, Genetica Groep Koeleman, Circulatory Health, Boerma, Ragna S., Braun, Kees P., van den Broek, Marcel P H, van Berkestijn, Frederique M C, Swinkels, Marielle E., Hagebeuk, Eveline O., Lindhout, Dick, van Kempen, Marjan, Boon, Maartje, Nicolai, Joost, de Kovel, Carolien G., Brilstra, Eva H., Koeleman, Bobby P C, Genetica Klinische Genetica, ZL Kinder Ner en Nec Medisch, Brain, Apotheek Klinische Farmacie, Klinische zorg, Other research (not in main researchprogram), Child Health, Genetica Sectie Genoomdiagnostiek, Genetica Groep Koeleman, Circulatory Health, Boerma, Ragna S., Braun, Kees P., van den Broek, Marcel P H, van Berkestijn, Frederique M C, Swinkels, Marielle E., Hagebeuk, Eveline O., Lindhout, Dick, van Kempen, Marjan, Boon, Maartje, Nicolai, Joost, de Kovel, Carolien G., Brilstra, Eva H., and Koeleman, Bobby P C

Published
2016

41. Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach

Author

Genetica Klinische Genetica, ZL Kinder Ner en Nec Medisch, Brain, Apotheek Klinische Farmacie, Klinische zorg, Other research (not in main researchprogram), Integrale & Alg. Kindergen Patientenzorg, Child Health, Genetica Sectie Genoomdiagnostiek, Genetica Groep Koeleman, Circulatory Health, Boerma, Ragna S., Braun, Kees P., van den Broek, Maarten P H, van Berkestijn, Frederique M C, Swinkels, Marielle E., Hagebeuk, Eveline O., Lindhout, Dick, van Kempen, Marjan, Boon, Maartje, Nicolai, Joost, de Kovel, Carolien G., Brilstra, Eva H., Koeleman, Bobby P C, Genetica Klinische Genetica, ZL Kinder Ner en Nec Medisch, Brain, Apotheek Klinische Farmacie, Klinische zorg, Other research (not in main researchprogram), Integrale & Alg. Kindergen Patientenzorg, Child Health, Genetica Sectie Genoomdiagnostiek, Genetica Groep Koeleman, Circulatory Health, Boerma, Ragna S., Braun, Kees P., van den Broek, Maarten P H, van Berkestijn, Frederique M C, Swinkels, Marielle E., Hagebeuk, Eveline O., Lindhout, Dick, van Kempen, Marjan, Boon, Maartje, Nicolai, Joost, de Kovel, Carolien G., Brilstra, Eva H., and Koeleman, Bobby P C

Published
2016

42. Genetic aspects of Multiple Sclerosis

Author

Boon, Maartje, Boon, Maartje, Boon, Maartje, and Boon, Maartje

Abstract

General introduction into Multiple Sclerosis (MS). Chapter 2 review of the literature on genetic epidemiology of MS with emphasis on whole genome screens. Chapter 3 Haplotype sharing, association analysis and TDT in the HLA region in MS patients. Support for a 50 kb interval containing HLA DQB1. Chapter 4: analysis of the inheritance mode of HLA-associated susceptibility: the effect is stronger than additive. Chapter 5: comparison of relapsing remitting/secondary progressive and primary progressive MS for HLA region: differences and similarities, suggesting that both types are part of a spectrum. Chapter 7 summary and conclusions, chapter 8 samenvatting.

Published
2006

43. The relation of emotion recognition and social behavioral problems in children with neurofibromatosis type 1: An explorative study

Author

Coenen, Maraike, Aarnoudse, Cecilia, Boon, Maartje, and Veenstra, Wencke

Subjects
CBCL, NF1, SOCIAL COGNITION, CHILDREN, BEHAVIORAL PROBLEMS
Abstract

OBJECTIVE: Children with neurofibromatosis type 1 (NF1) often show cognitive and behavioral problems (Martin et al., 2011). Huijbregts et al. (2010) investigated cognitive problems in children with NF1 focusing on social information processing. They found that bottom-up as well as top-down processes are involved. The authors suggested that the deficits in social information processing might be linked to social behavioral problems (Huijbregts et al., 2010). To further investigate this issue, the aim of the present study is to assess the relation between social behavioral problems and deficits in emotion recognition. PARTICIPANTS AND METHOD: 14 children with NF1 between 5.00-13.00 years of age (6 boys, 8 girls; MAge=8.3, SDAge=2.8; MIQ=100.71, SDIQ=11,56) took part in our study. 6 children were 10 years and older, 8 children were younger than 10. Emotion recognition was assessed with the Dutch shortened version of the Facial Expression of Emotions – Stimuli and Tests (FEEST-36; original test by Young et al. 2002) and parents reported social behavioral problems on the Child Behavior Checklist 6-18 (CBCL; Achenbach, 1991). Data of the FEEST-36 were compared to an age- gender- and IQ-matched control group (n=28; 15 boys, 13 girls; MAge=8.1, SDAge=1,10; MIQ=104.93, SDIQ=10.6). RESULTS: There was no significant difference in facial emotion recognition between children with NF1 and typically developing children younger than 10. Children with NF1 of 10 years and older were significantly less accurate in recognizing anger, fear and sadness in facial emotions than typically developing children. Four parents reported problematic social behavior for their child on the CBCL. The social behavioral problems were significantly correlated with recognition of sadness in children with NF1 of 10 years and older. DISCUSSION: In our sample, emotion recognition in children with NF1 younger than 10 years was not different from typically developing children. This might indicate a low sensitivity of the FEEST-36. The test does not seem to be able to detect emotion recognition deficits in children with NF1 younger than 10 years. For children with NF1 older than 10 years of age, we found impaired fear recognition. Furthermore, we also found an impairment of recognition of anger and sadness. Especially the recognition of sadness is related to social behavioral problems. More research is needed on the development of social cognition in children with NF1 and the relation with behavioral problems in order to tailor intervention strategies to improve social functioning of these children.

Published
2014

45. Erratum to: Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach

Author

Boerma, Ragna S., primary, Braun, Kees P., additional, van den Broek, Marcel P. H., additional, van Berkestijn, Frederique M. C., additional, Swinkels, Marielle E., additional, Hagebeuk, Eveline O., additional, Lindhout, Dick, additional, van Kempen, Marjan, additional, Boon, Maartje, additional, Nicolai, Joost, additional, de Kovel, Carolien G., additional, Brilstra, Eva H., additional, and Koeleman, Bobby P. C., additional

Published
2015
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46. Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach

Author

Boerma, Ragna S., primary, Braun, Kees P., additional, van de Broek, Maarten P. H., additional, van Berkestijn, Frederique M. C., additional, Swinkels, Marielle E., additional, Hagebeuk, Eveline O., additional, Lindhout, Dick, additional, van Kempen, Marjan, additional, Boon, Maartje, additional, Nicolai, Joost, additional, de Kovel, Carolien G., additional, Brilstra, Eva H., additional, and Koeleman, Bobby P. C., additional

Published
2015
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47. Mapping of a susceptibility gene for multiple sclerosis to the 51 kb interval between G511525 and D6S1666 using a new method of haplotype sharing analysis

Author

Nolte, I.m., Bruinenberg, M., Spijker, G.t., Terpstra, Marin, De Keyser, Jacques, Zwanikken, C.p., Hulsbeek, M., Hofstra, R.m., Buys, C.h., Te Meerman, G.j., Boon, Maartje, Raelson, J., and Gerontology

Subjects
Histocompatibility Testing, Haplotypes/genetics, Multiple Sclerosis/genetics, Cluster Analysis, Genetic Predisposition to Disease, Linkage Disequilibrium, DNA Primers, Human
Abstract

Multiple sclerosis (MS) is a complex disease that is partly genetic in origin. Although an association of MS with specific human leukocyte antigen (HLA) types has been known for almost 30 years, the nature of this relationship has remained unclear. Furthermore, genetic resolution sufficient to implicate a specific gene in the HLA region has not been achieved. Many loci in the HLA region have been found to be significantly associated with MS, which is largely explained by the extended haplotype sharing and varying marker informativity of the region. We have determined 248 haplotypes of MS patients from the population of the northern Netherlands and 226 haplotypes of their relatives as controls using a set of 22 microsatellite markers covering the HLA region. The data were analyzed using standard association methods and a new statistical method, haplotype sharing statistics (HSS). Haplotype sharing statistics determines the extent of haplotype sharing for all pairs of haplotypes of patients and of controls and calculates the difference in mean haplotype sharing between patients and controls. Haplotype sharing was found to be significantly greater among patients than among controls in a region of 1.1 Mb between markers G511525 and TNFalpha. The involvement of this region is also supported by association analysis and the transmission/disequilibrium test (TDT). Within this region, HSS, which is largely independent of association and TDT, indicated the interval of 51 kb between G511525 and D6S1666 as that most likely to contain a susceptibility gene for MS. As DQB1 is the sole gene known in this interval at present, the results of our analysis suggest that this gene plays a role in the pathogenesis of MS

Published
2001

49. The management of multiple sclerosis in children: a European view

Author

Ghezzi, Angelo, Banwell, Brenda, Boyko, Alexey, Amato, Maria Pia, Anlar, Banu, Blinkenberg, Morten, Boon, Maartje, Filippi, Massimo, Jozwiak, Sergiusz, Ketelslegers, Immy, Kornek, Barbara, Lim, Ming, Lindstrom, Eva, Nadj, Congor, Neuteboom, Rinze, Rocca, Maria A, Rostasy, Kevin, Tardieu, Marc, Wassmer, Evangeline, Catsman-Berrevoets, Coriene, Hintzen, Rogier, Ghezzi, Angelo, Banwell, Brenda, Boyko, Alexey, Amato, Maria Pia, Anlar, Banu, Blinkenberg, Morten, Boon, Maartje, Filippi, Massimo, Jozwiak, Sergiusz, Ketelslegers, Immy, Kornek, Barbara, Lim, Ming, Lindstrom, Eva, Nadj, Congor, Neuteboom, Rinze, Rocca, Maria A, Rostasy, Kevin, Tardieu, Marc, Wassmer, Evangeline, Catsman-Berrevoets, Coriene, and Hintzen, Rogier

Abstract

About 3-5% of all patients with multiple sclerosis experience the onset of their disease under the age of 16. A significant proportion of paediatric multiple sclerosis patients develop significant cognitive disturbances and persistent physical disability. The high relapse rate and the morbidity in the paediatric multiple sclerosis population has triggered the use of disease-modifying therapies that have been shown to reduce relapse rate, disease progression and cognitive decline in adult patients with multiple sclerosis. Hard evidence for the right treatment and its appropriate timing is scarce in paediatric multiple sclerosis. Nevertheless, expertise in this field has grown thanks to recent open-label trials and experience generated in specialized centres. In spring 2009, a first meeting was held in Rotterdam with clinicians from 11 European countries (one from Canada) that are all active in the management of paediatric multiple sclerosis. One of the aims was to generate a common view on the management of paediatric multiple sclerosis patients. The result of this meeting is presented here to help standardize treatment and to support clinicians with less experience in this field.

Published
2010

50. PRRT2phenotypes and penetrance of paroxysmal kinesigenic dyskinesia and infantile convulsions

Author

van Vliet, Rianne, primary, Breedveld, Guido, additional, de Rijk-van Andel, Johanneke, additional, Brilstra, Eva, additional, Verbeek, Nienke, additional, Verschuuren-Bemelmans, Corien, additional, Boon, Maartje, additional, Samijn, Johnny, additional, Diderich, Karin, additional, van de Laar, Ingrid, additional, Oostra, Ben, additional, Bonifati, Vincenzo, additional, and Maat-Kievit, Anneke, additional

Published
2012
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