1. A P Systems Variant for Reasoning about Sequential Controllability of Boolean Networks
- Author
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Alhazov, Artiom, Ferrari-Dominguez, Vincent, Freund, Rudolf, Glade, Nicolas, Ivanov, Sergiu, Vladimir Andrunachievici Institute of Mathematics and Computer Science, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL), Faculty of Informatics, Vienna University of Technology (TU Wien), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Informatique, BioInformatique, Systèmes Complexes (IBISC), and Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay
- Subjects
FOS: Computer and information sciences ,Formal Languages and Automata Theory (cs.FL) ,[INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO] ,Computer Science - Formal Languages and Automata Theory ,Complexity ,Reachability ,[INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL] ,Boolean networks ,Boolean P systems - Abstract
A Boolean network is a discrete dynamical system operating on vectors of Boolean variables. The action of a Boolean network can be conveniently expressed as a system of Boolean update functions, computing the new values for each component of the Boolean vector as a function of the other components. Boolean networks are widely used in modelling biological systems that can be seen as consisting of entities which can be activated or deactivated, expressed or inhibited, on or off. P systems on the other hand are classically introduced as a model of hierarchical multiset rewriting. However, over the years the community has proposed a wide range of P system variants including diverse ingredients suited for various needs. In this work, we propose a new variant -- Boolean P systems -- specifically designed for reasoning about sequential controllability of Boolean networks, and use it to first establish a crisp formalization of the problem, and then to prove that the problem of sequential controllability is PSPACE-complete. We further claim that Boolean P systems are a demonstration of how P systems can be used to construct ad hoc formalisms, custom-tailored for reasoning about specific problems, and providing new advantageous points of view., Comment: arXiv admin note: substantial text overlap with arXiv:2208.14723
- Published
- 2023
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