182 results on '"Bonte FJ"'
Search Results
2. Imaging bruxism.
- Author
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Bonte FJ and Harris TS
- Subjects
- Bruxism diagnostic imaging, Cerebrovascular Circulation, Female, Humans, Middle Aged, Regional Blood Flow, Tomography, Emission-Computed, Single-Photon, Bruxism diagnosis, Diagnostic Imaging methods
- Abstract
A 62-year-old woman was referred for SPECT brain blood flow study with a diagnosis of possible dementia or depression. Findings within the brain were noncontributory, but extraneous structures with high blood flow were detected within the soft tissues of temporal regions and face. On questioning, the patient stated that she had sleep bruxism, with gnashing and grinding of her teeth. This did not occur during waking. Bruxisms and its consequences, with effects on the teeth and jaws, are a problem of importance to oral surgeons and dentists. There is considerable active research into methods of treatment of sleep bruxism. more...
- Published
- 2013
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- View/download PDF
Catalog
3. TC-99m HMPAO Brain Blood Flow Imaging in the Dementias with Histopathologic Correlation in 73 Patients.
- Author
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Bonte FJ, Hynan L, Harris TS, and White CL 3rd
- Abstract
The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias. Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Images were further processed using Statistical Parametric Mapping. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 73 subjects were compared with a neuropathologic study of the brain at autopsy. Data were analyzed for sensitivity, specificity, positive and negative predictive values and accuracy. These results are compared with several other studies performed with Tc-99m HMPAO SPECT with histopathologic correlation. This procedure is widely available and relatively inexpensive and may be of value in patients with dementias and problematic diagnoses. Further, a degree of differential diagnosis between Alzheimer's and Frontotemporal diseases may be effected. The study was approved by our Institutional Review Board. more...
- Published
- 2011
- Full Text
- View/download PDF
4. Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease.
- Author
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Roney CA, Arora V, Kulkarni PV, Antich PP, and Bonte FJ
- Abstract
Detecting aggregated amyloid peptides (Abeta plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity (125)I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. (125)I-CQ-PBCA NPs crossed the BBB (2.3 +/- 0.9 ID/g) (P < .05) in the WT mouse (N = 210), compared to (125)I-CQ (1.0 +/- 0.4 ID/g). (125)I-CQ-PBCA NP brain uptake increased in AD transgenic mice (APP/PS1) versus WT (N = 38; 2.54 x 10(5) +/- 5.31 x 10(4) DLU/mm(2); versus 1.98 x 10(5) +/- 2.22 x 10(4) DLU/mm(2)) and in APP/PS1/Tau. Brain increases were in mice intracranially injected with aggregated Abeta(42) peptide (N = 17; 7.19 x 10(5) +/- 1.25 x 10(5) DLU/mm(2)), versus WT (6.07 x 10(5) +/- 7.47 x 10(4) DLU/mm(2)). Storage phosphor imaging and histopathological staining of the plaques, Fe(2+) and Cu(2+), validated results. (125)I-CQ-PBCA NPs have specificity for Abeta in vitro and in vivo and are promising as in vivo SPECT ((123)I), or PET ((124)I) amyloid imaging agents. more...
- Published
- 2010
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5. Quinoline-n-butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's disease.
- Author
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Kulkarni PV, Roney CA, Antich PP, Bonte FJ, Raghu AV, and Aminabhavi TM
- Subjects
- Alzheimer Disease metabolism, Animals, Blood-Brain Barrier metabolism, Brain metabolism, Drug Delivery Systems methods, Humans, Mice, Mice, Transgenic, Alzheimer Disease diagnosis, Brain pathology, Enbucrilate pharmacokinetics, Nanoparticles, Quinolines pharmacokinetics
- Abstract
A survey of research activity on nanoparticles (NPs) based on polymeric devices that could cross the blood-brain barrier (BBB) is given along with the presentation of our own data on the development of NPs of n-butyl-2-cyanoacrylate (BCA) for brain delivery to aid the early diagnosis of Alzheimer's disease (AD), a neurodegenerative disorder of the elderly people, the most prevalent form of dementia. Typical data are presented on in vivo detection of amyloid peptides (A beta) (amyloid plaques) that are used as targets for developing the biological markers for the diagnosis of AD. In order to develop efficient in vivo probes, polymeric n-butyl-2-cyanoacrylate (PBCA) NPs have been prepared and encapsulated with the radio-labeled amyloid affinity drug (125)I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) to improve the transport to brain and amyloid plaque retention of (125)I-CQ using the NPs of PBCA. The (125)I-CQ discriminately binds to the AD post-mortem brain tissue homogenates versus control. (125)I-CQ-PBCA NPs labeled the A beta plaques from the AD human post-mortem frontal cortical sections on paraffin-fixed slides. Storage phosphor imaging verified preferential uptake by AD brain sections compared to cortical control sections. The (125)I-CQ-PBCA NPs crossed the BBB in wild type mouse, giving an increased brain uptake measured in terms of % ID/g i.e., injected dose compared to (125)I-CQ. Brain retention of (125)I-CQ-PBCA NPs was significantly increased in the AD transgenic mice (APP/PS1) and in mice injected with aggregated A beta 42 peptide versus age-matched wild type controls. The results of this study are verified by in vivo storage phosphor imaging and validated by histopathological staining of plaques and select metal ions, viz. Fe(2+) and Cu(2+). The (125)I-CQ-PBCA NPs had more efficient brain entry and rapid clearance in normal mice and enhanced the retention in AD mouse brain demonstrating the ideal in vivo imaging characteristics. The (125)I-CQ-PBCA NPs exhibited specificity for A beta plaques both in vitro and in vivo. This combination offered radio-iodinated CQ-PBCA NPs as the promising delivery vehicle for in vivo single photon emission tomography (SPECT) ((123)I) or PET ((124)I) amyloid imaging agent. The importance of the topic in relation to brain delivery and other similar type of work published in this area are covered to highlight the importance of this research to medical disciplines., ((c) 2009 John Wiley & Sons, Inc.) more...
- Published
- 2010
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6. Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 Gulf War.
- Author
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Haley RW, Spence JS, Carmack PS, Gunst RF, Schucany WR, Petty F, Devous MD Sr, Bonte FJ, and Trivedi MH
- Subjects
- Adult, Brain blood supply, Brain diagnostic imaging, Dominance, Cerebral physiology, Humans, Male, Middle Aged, Neurons drug effects, Neurons physiology, Neuropsychological Tests, Neurotoxicity Syndromes diagnostic imaging, Persian Gulf Syndrome diagnostic imaging, Persian Gulf Syndrome physiopathology, Regional Blood Flow drug effects, Technetium Tc 99m Exametazime, Cholinesterase Inhibitors toxicity, Environmental Exposure, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Neurotoxicity Syndromes physiopathology, Persian Gulf Syndrome chemically induced, Physostigmine, Receptors, Cholinergic drug effects, Tomography, Emission-Computed, Single-Photon, Veterans
- Abstract
Several case definitions of chronic illness in veterans of the 1991 Persian Gulf War have been linked epidemiologically with environmental exposure to cholinesterase-inhibiting chemicals, which cause chronic changes in cholinergic receptors in animal models. Twenty-one chronically ill Gulf War veterans (5 with symptom complex 1, 11 with complex 2, and 5 with complex 3) and 17 age-, sex- and education-matched controls, underwent an 99mTc-HMPAO-SPECT brain scan following infusion of saline and >48 h later a second scan following infusion of physostigmine in saline. From each SPECT image mean normalized regional cerebral blood flow (nrCBF) from 39 small blocks of correlated voxels were extracted with geostatistical spatial modeling from eight deep gray matter structures in each hemisphere. Baseline nrCBF in symptom complex 2 was lower than controls throughout deep structures. The change in nrCBF after physostigmine (challenge minus baseline) was negative in complexes 1 and 3 and controls but positive in complex 2 in some structures. Since effects were opposite in different groups, no finding typified the entire patient sample. A hold-out discriminant model of nrCBF from 17 deep brain blocks predicted membership in the clinical groups with sensitivity of 0.95 and specificity of 0.82. Gulf War-associated chronic encephalopathy in a subset of veterans may be due to neuronal dysfunction, including abnormal cholinergic response, in deep brain structures. more...
- Published
- 2009
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7. Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.
- Author
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Bonte FJ, Harris TS, Hynan LS, Bigio EH, and White CL 3rd
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease diagnostic imaging, Dementia pathology, Diagnosis, Differential, False Negative Reactions, False Positive Reactions, Female, Humans, Male, Predictive Value of Tests, Reproducibility of Results, Sensitivity and Specificity, Cerebrovascular Circulation, Dementia diagnostic imaging, Radiopharmaceuticals, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Single-Photon instrumentation, Tomography, Emission-Computed, Single-Photon methods
- Abstract
Purpose: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease., Materials and Methods: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy., Results: Sensitivity = 86.7% (68.4-95.6%, 95% confidence interval [CI]), specificity = 89.5% (65.5-98.2% CI), positive predictive value = 92.9% (75.0-98.8% CI), negative predictive value = 81% (57.4-93.7% CI), accuracy = 87.8% (74.5-94.9% CI), likelihood ratio = 8.23% (7.09-9.57% CI)., Conclusions: Comparison is made with several other SPECT and PET series with histopathologic correlation. Brain blood flow SPECT is useful in the diagnosis and differential diagnosis of the dementias. more...
- Published
- 2006
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8. Convergence of connected language and SPECT in variants of frontotemporal lobar degeneration.
- Author
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Chapman SB, Bonte FJ, Wong SB, Zientz JN, Hynan LS, Harris TS, Gorman AR, Roney CA, and Lipton AM
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- Aged, Brain diagnostic imaging, Dementia diagnostic imaging, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Reproducibility of Results, Tomography, Emission-Computed, Single-Photon, Brain physiopathology, Cerebrovascular Circulation physiology, Dementia physiopathology, Dementia psychology, Language
- Abstract
The characterization of frontotemporal lobar degeneration (FTLD) is complicated and not widely recognized. Connected language measures (ie, discourse) and functional neuroimaging may advance knowledge specifying early distinctions among frontal dementias. The present study examined the correspondence of discourse measures with (1) clinical diagnosis and (2) single photon emission computed tomography (SPECT) imaging. Nineteen subjects were selected from Alzheimer's Disease Center (ADC) participants if they were diagnosed with early-stage frontotemporal lobar degeneration and also underwent single photon emission computed tomography and discourse evaluation. First, clinical diagnoses given by specialists at an Alzheimer's Disease Center were compared with the discourse-based diagnostic profiles. Secondly, compromised brain regions that were predicted from discourse profiles were compared with SPECT findings. Results revealed a significant correspondence between the ADC diagnosis and the discourse-based diagnoses. Also, the discourse profiles across frontotemporal lobar degeneration subtypes were consistently associated with distinctive patterns of SPECT hypometabolism in the right frontal, left frontal, or left temporal lobes. These findings suggest that discourse methods may be systematized to provide an efficient adjunct measure beyond the traditional word and sentential level measures. Objectifying complex language performance may contribute to early detection and differentiation among frontotemporal lobar degeneration variants because consensus in the literature states that language is a core disturbance of frontotemporal lobar degeneration. more...
- Published
- 2005
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9. Differential diagnosis between Alzheimer's and frontotemporal disease by the posterior cingulate sign.
- Author
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Bonte FJ, Harris TS, Roney CA, and Hynan LS
- Subjects
- Aged, Case-Control Studies, Cerebrovascular Circulation physiology, Diagnosis, Differential, Frontal Lobe diagnostic imaging, Humans, Predictive Value of Tests, Radiopharmaceuticals, Sensitivity and Specificity, Technetium Tc 99m Exametazime, Temporal Lobe diagnostic imaging, Tomography, Emission-Computed, Single-Photon, Alzheimer Disease diagnostic imaging, Brain diagnostic imaging, Dementia diagnostic imaging, Gyrus Cinguli diagnostic imaging
- Abstract
Unlabelled: This was a study to evaluate the posterior cingulate sign in differential diagnosis between Alzheimer's and frontotemporal disease. The impending availability of effective treatment for Alzheimer's disease makes this differential diagnosis important., Methods: Images of 20 patients with clinically confirmed or autopsy-proven (10 patients) Alzheimer's disease and 20 patients with clinically confirmed or autopsy-proven (7 patients) frontotemporal disease were compared with the consolidated images of 20 elderly healthy control subjects. The (99m)Tc-hexamethylpropyleneamine oxime SPECT data on brain blood flow from each patient were compared with the consolidated control image using statistical parametric mapping., Results: Sixteen of 20 patients with Alzheimer's disease showed the posterior cingulate sign in the form of significant blood flow reductions; 1 of 20 patients with frontotemporal disease showed the posterior cingulate sign. That patient's illness has evolved into Alzheimer's disease. The remaining 19 patients were negative for the posterior cingulate sign., Conclusion: When present, the posterior cingulate sign indicates the presence of Alzheimer's disease; it is apparently absent in frontotemporal disease, thus serving as a differential diagnostic sign. It was absent in 3 patients with proven tangle-predominant Alzheimer's disease. more...
- Published
- 2004
10. Lateralization on neuroimaging does not differentiate frontotemporal lobar degeneration from Alzheimer's disease.
- Author
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Lipton AM, Benavides R, Hynan LS, Bonte FJ, Harris TS, White CL 3rd, and Bigio EH
- Subjects
- Alzheimer Disease physiopathology, Cerebrovascular Circulation, Dementia physiopathology, Diagnosis, Differential, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Radiopharmaceuticals, Sensitivity and Specificity, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed, Alzheimer Disease diagnosis, Alzheimer Disease psychology, Dementia diagnosis, Dementia psychology, Dominance, Cerebral
- Abstract
Lateralization on neuroimaging was compared in cases of frontotemporal lobar degeneration (FTLD; n = 10) and cases of definite Alzheimer's disease (AD; n = 17). All of the cases were pathologically confirmed and semi-quantitative and statistical parametric mapping methods were employed. Seven of the 10 FTLD cases had lateralization on at least one neuroimaging modality: single photon emission computerized tomography (SPECT), MRI, or CT. All 6/6 FTLD cases with SPECT showed lateralization. MRI results generally agreed with SPECT findings. Three of 4 FTLD cases had lateralized atrophy on CT. For the AD cases, 10/17 SPECTs, 2/7 MRIs, and 1/9 CTs showed lateralized findings. Of the neuroimaging modalities utilized, SPECT was the most sensitive in detecting lateralization., (Copyright 2004 S. Karger AG, Basel) more...
- Published
- 2004
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11. Differential activation on fMRI of monozygotic twins discordant for AD.
- Author
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Lipton AM, McColl R, Cullum CM, Allen G, Ringe WK, Bonte FJ, McDonald E, and Rubin CD
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- Aged, Alzheimer Disease diagnostic imaging, Alzheimer Disease genetics, Apolipoprotein E4, Apolipoproteins E genetics, Brain Mapping, Cerebral Cortex diagnostic imaging, Cerebral Cortex physiopathology, Homozygote, Humans, Male, Memory Disorders genetics, Memory Disorders pathology, Neuropsychological Tests, Parietal Lobe diagnostic imaging, Parietal Lobe pathology, Parietal Lobe physiopathology, Radionuclide Imaging, Single-Blind Method, Subtraction Technique, Verbal Learning, Alzheimer Disease pathology, Cerebral Cortex pathology, Diseases in Twins, Magnetic Resonance Imaging, Twins, Monozygotic
- Abstract
This is the first report of fMRI in monozygotic twins discordant for AD. FMRI brain activation patterns were examined during visuospatial and verbal working memory tasks. The affected twin had greater parietal involvement bilaterally during both working memory tasks and reduced left dorsolateral prefrontal cortex activity on the visuospatial memory task. Thus, fMRI may identify additional brain regions recruited in patients with AD to perform a given cognitive task. more...
- Published
- 2003
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12. Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease.
- Author
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Bigio EH, Reisch JS, White CL 3rd, Satumtira S, Sontag E, and Bonte FJ
- Subjects
- Aged, Brain pathology, Brain ultrastructure, Case-Control Studies, Cerebrovascular Circulation, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Synaptophysin analysis, Tomography, Emission-Computed, Single-Photon, Alzheimer Disease pathology, Alzheimer Disease physiopathology, Brain blood supply, Synapses pathology
- Abstract
In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD., (Copyright 2003 S. Karger AG, Basel) more...
- Published
- 2003
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13. Occipital brain perfusion deficits in children with major depressive disorder.
- Author
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Bonte FJ, Trivedi MH, Devous MD Sr, Harris TS, Payne JK, Weinberg WA, and Haley RW
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- Adolescent, Brain Mapping, Child, Depressive Disorder diagnostic imaging, Female, Humans, Male, Cerebrovascular Circulation, Depressive Disorder physiopathology, Occipital Lobe blood supply, Tomography, Emission-Computed, Single-Photon
- Abstract
Unlabelled: Occipital lobe perfusion defects have been identified on regional cerebral blood flow (rCBF) SPECT scans of adolescent children and young adults with major depressive disorder (MDD). We reinvestigated a series of rCBF SPECT scans obtained several years ago on drug-naive children with a clinical diagnosis of MDD and on healthy children., Methods: To test whether visually apparent abnormalities in rCBF constitute statistically significant differences between patients, given the relatively small sample sizes, we applied the technique of statistical parametric mapping (SPM)., Results: Two groups of patients were identified: 8 with significant posterior flow deficits in the occipital cortex (Brodmann's areas 18 and 19), usually symmetric, and best visualized on paramedian sagittal sections, and 13 without obvious occipital perfusion deficits but with anterior rCBF deficits in a pattern often described in the literature, attaining statistical significance in the right frontal region. Other localizations in the left frontal and bilateral prefrontal regions did not attain significance, but each localization contained statistically significant maxima (z scores). The scan findings of all 18 healthy children were normal., Conclusion: With the aid of SPM, 2 groups of children with significantly different rCBF behavior were identified. The reason for this difference is not known but should be investigated to determine its possible significance to patients with MDD. more...
- Published
- 2001
14. SPECT imaging in dementias.
- Author
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Bonte FJ, Weiner MF, Bigio EH, and White CL 3rd
- Subjects
- Aged, Aged, 80 and over, Humans, Middle Aged, Alzheimer Disease diagnostic imaging, Brain diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Published
- 2001
15. Brain blood flow SPECT: posterior flow deficits in young patients with depression.
- Author
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Bonte FJ
- Subjects
- Adolescent, Adult, Alzheimer Disease diagnostic imaging, Bipolar Disorder diagnostic imaging, Cerebral Cortex diagnostic imaging, Cerebrovascular Circulation, Diagnosis, Differential, Female, Humans, Male, Radiopharmaceuticals, Substance-Related Disorders complications, Technetium Tc 99m Exametazime, Cerebral Cortex blood supply, Depressive Disorder diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Published
- 1999
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16. Familial dementia due to adult polyglucosan body disease.
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Bigio EH, Weiner MF, Bonte FJ, and White CL
- Subjects
- Dementia pathology, Female, Histocytochemistry, Humans, Male, Microscopy, Electron, Middle Aged, Motor Neuron Disease metabolism, Dementia genetics, Glucans analysis, Inclusion Bodies pathology, Motor Neuron Disease pathology
- Abstract
Background: Adult polyglucosan body disease (APBD) is a rare disorder, presenting with varying combinations and severity of upper and lower motor neuron dysfunction, sensory deficits, dementia, and urinary incontinence. Onset is in the 40s or 50s. The diagnosis is made by finding polyglucosan bodies (PB) in histologic sections of brain or spinal cord, peripheral nerve, or dermal sweat glands. Although 2 pairs of the 22 previously reported cases were siblings, the familial nature of the disease has not been emphasized., Methods: We report 2 adult siblings, a male and a female, each of whom had the clinical diagnosis of vascular dementia. Both were confirmed at autopsy to have APBD. We characterized the lesions in autopsy tissues using a battery of histological stains, lectin histochemistry, and electron microscopy., Results: Innumerable PB were distributed throughout brain, heart, skeletal muscle, liver, and dermal sweat glands. PB were highlighted by periodic acid Schiff stain and concanavalin A lectin. Ultrastructurally, PB were composed of aggregates of filaments within axons and astrocytic processes, and lying free in the neuropil, but not within neuronal perikarya., Conclusions: It is important to consider APBD in cases of familial dementia of unknown etiology. Ante-mortem biopsy of axillary skin may be diagnostic. more...
- Published
- 1997
17. Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients.
- Author
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Bonte FJ, Weiner MF, Bigio EH, and White CL 3rd
- Subjects
- Aged, Aged, 80 and over, Alzheimer Disease diagnostic imaging, Alzheimer Disease physiopathology, Brain diagnostic imaging, Dementia physiopathology, Diagnosis, Differential, False Negative Reactions, False Positive Reactions, Female, Humans, Male, Middle Aged, Organotechnetium Compounds, Oximes, Predictive Value of Tests, Sensitivity and Specificity, Technetium Tc 99m Exametazime, Xenon Radioisotopes, Cerebrovascular Circulation, Dementia diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Abstract
Purpose: To evaluate single photon emission computed tomographic (SPECT) imaging of regional cerebral blood flow in the diagnosis of Alzheimer disease (AD) and the differential diagnosis of the dementias., Materials and Methods: Regional cerebral blood flow SPECT was performed with inhaled xenon-133 in 261 patients and with injected technetium-99m hexamethyl-propyleneamine oxime (HMPAO) in 162 patients with possible dementia. In 16 patients, both agents were used in 1 day. SPECT images obtained in elderly healthy control subjects (with Xe-133 in 15, with Tc-99m HMPAO in 14) were available. In each patient without AD, further classification of disease was attempted. Histopathologic correlation was available in 54 patients (with autopsy in 51, with biopsy in three)., Results: SPECT diagnoses were true-positive in 37, true-negative in eight, false-positive in three, and false-negative in six patients. Sensitivity was 86% (37 of 43; 95% confidence limits = .72, .95); specificity, 73% (eight of 11; confidence limits = .39, .94); positive predictive value, 92% (37 of 40; confidence limits = .80, .98); and negative predictive value, 57% (eight of 14; confidence limits = .29, .82)., Conclusion: Regional cerebral blood flow SPECT may assist in the early and late diagnoses of AD and in the differential-diagnosis of the dementias when there is a complicated or confusing clinical picture. more...
- Published
- 1997
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18. Evaluation of neurologic function in Gulf War veterans. A blinded case-control study.
- Author
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Haley RW, Hom J, Roland PS, Bryan WW, Van Ness PC, Bonte FJ, Devous MD Sr, Mathews D, Fleckenstein JL, Wians FH Jr, Wolfe GI, and Kurt TL
- Subjects
- Adult, Ataxia, Brain diagnostic imaging, Brain pathology, Case-Control Studies, Central Nervous System Diseases diagnosis, Central Nervous System Diseases epidemiology, Cognition Disorders, Evoked Potentials, Hematologic Tests, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Muscular Diseases, Neurologic Examination, Nystagmus, Pathologic, Peripheral Nervous System Diseases diagnosis, Peripheral Nervous System Diseases epidemiology, Tomography, Emission-Computed, Single-Photon, United States epidemiology, Vestibular Function Tests, Veterans, Central Nervous System Diseases etiology, Neuropsychological Tests, Peripheral Nervous System Diseases etiology, Persian Gulf Syndrome diagnosis, Persian Gulf Syndrome epidemiology
- Abstract
Objective: To determine whether Gulf War-related illnesses are associated with central or peripheral nervous system dysfunction., Design: Nested case-control study., Participants: Twenty-three veterans with factor analysis-derived syndromes (the cases), 10 well veterans deployed to the Gulf War (the deployed controls), and 10 well veterans not deployed to the Gulf War (the nondeployed controls)., Method: With investigators blinded to group identities, participants underwent objective neurophysiological, audiovestibular, neuroradiological, neuropsychological, and blood tests., Main Outcome Measures: Evidence of neurologic dysfunction., Results: Compared with the 20 controls, the 23 cases had significantly more neuropsychological evidence of brain dysfunction on the Halstead Impairment Index (P=.01), greater interside asymmetry of the wave I to wave III interpeak latency of brain stem auditory evoked potentials (P=.02), greater interocular asymmetry of nystagmic velocity on rotational testing, increased asymmetry of saccadic velocity (P=.04), more prolonged interpeak latency of the lumbar-to-cerebral peaks on posterior tibial somatosensory evoked potentials (on right side, P=.03, and on the left side, P=.005), and diminished nystagmic velocity after caloric stimulation bilaterally (P values range from .02 to .04). Cases (n=5) with syndrome 1 ("impaired cognition") were the most impaired on brain stem auditory evoked potentials (P=.005); those (n=13) with syndrome 2 ("confusion-ataxia") were the most impaired on the Halstead Impairment Index (P=.006), rotational testing (P=.01), asymmetry of saccadic velocity (P=.03), and somatosensory evoked potentials (P< or =.01); and those (n=5) with syndrome 3 ("arthro-myo-neuropathy") were the most impaired on caloric stimulation (P< or =.01)., Conclusions: The 3 factor-derived syndromes identified among Gulf War veterans appear to represent variants of a generalized injury to the nervous system. more...
- Published
- 1997
19. The evolution of nuclear medicine.
- Author
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Bonte FJ
- Subjects
- Europe, History, 19th Century, History, 20th Century, Humans, United States, Nuclear Medicine history, Radiology history
- Published
- 1995
20. High-voltage electric injury: assessment of muscle viability with MR imaging and Tc-99m pyrophosphate scintigraphy.
- Author
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Fleckenstein JL, Chason DP, Bonte FJ, Parkey RW, Hunt JL, Purdue GF, and Burns DK
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- Amputation, Surgical, Contrast Media, Drug Combinations, Electric Injuries diagnostic imaging, Electric Injuries surgery, Gadolinium DTPA, Humans, Magnetic Resonance Imaging, Meglumine, Muscle, Skeletal diagnostic imaging, Organometallic Compounds, Pentetic Acid analogs & derivatives, Radionuclide Imaging, Sensitivity and Specificity, Technetium Tc 99m Pyrophosphate, Electric Injuries diagnosis, Extremities injuries, Muscle, Skeletal injuries
- Abstract
Purpose: To evaluate use of magnetic resonance (MR) imaging and technetium-99m pyrophosphate (PYP) scintigraphy in preoperative assessment of muscle viability after high-voltage electric injury., Materials and Methods: Twelve injured limbs were studied. Immediate, equilibrium, and delayed Tc-99m PYP scintigrams and gadolinium-enhanced and unenhanced MR images were obtained. Imaging results were compared with clinical findings., Results: Scintigraphy demonstrated nonperfusion in four limbs that were subsequently amputated, but MR imaging had poor sensitivity in nonperfused regions owing to lack of edema. Tc-99m PYP uptake increased at transition zones between normal and nonperfused regions. MR imaging allowed further characterization of these zones by demonstrating edema as enhancing (perfused) or nonenhancing (nonperfused). In all nonamputated limbs, edema showed enhancement., Conclusion: In high-voltage electric injury, gadolinium-enhanced MR imaging appears able to demonstrate zones of potential viability within radionuclide-avid tissue but has poor perfusion sensitivity when used alone. more...
- Published
- 1995
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21. Cognitive deficits in asymptomatic first-degree relatives of Alzheimer's disease patients.
- Author
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Hom J, Turner MB, Risser R, Bonte FJ, and Tintner R
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- Aged, Alzheimer Disease diagnosis, Alzheimer Disease psychology, Cognition Disorders diagnosis, Cognition Disorders psychology, Consanguinity, Female, Genetic Markers genetics, Humans, Male, Mental Recall, Middle Aged, Psychometrics, Alzheimer Disease genetics, Cognition Disorders genetics, Neuropsychological Tests statistics & numerical data
- Abstract
The present study was designed to determine whether neuropsychological deficits exist in asymptomatic first-degree relatives of Alzheimer's disease (AD) patients. The neuropsychological performances of 20 first-degree asymptomatic relatives of NINCDS-ADRDA diagnosed AD patients were compared to 20 normal controls without family history of AD. Cognitive functions assessed included intelligence, memory, overall brain function, verbal learning, and language and constructional abilities. Significant statistical differences were found between the groups across several cognitive areas indicating lower functioning in the first-degree relatives of AD patients. Fifty percent of the first-degree subjects but only 20% of controls showed a pattern of significant neuropsychological deficit. The results demonstrate neuropsychological deficits in asymptomatic first-degree relatives of AD patients, suggesting that preclinical markers for AD may be present long before the clinical manifestation of the disease. more...
- Published
- 1994
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22. Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: what is typical?
- Author
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Weiner MF, Wighton-Benn WH, Risser R, Svetlik D, Tintner R, Hom J, Rosenberg RN, and Bonte FJ
- Subjects
- Aged, Alzheimer Disease psychology, Humans, Middle Aged, Psychiatric Status Rating Scales, Tomography, Emission-Computed, Single-Photon, Alzheimer Disease diagnostic imaging, Alzheimer Disease physiopathology, Cerebrovascular Circulation physiology, Xenon Radioisotopes
- Abstract
A study of 76 consecutive xenon-133 SPECT studies of regional cerebral blood flow was undertaken to determine the frequency of various patterns of blood flow in cases of clinically diagnosed probable and possible Alzheimer's disease. The reference tomographic section was a slice 6 cm above and parallel to the canthomeatal line. With the use of this technique, the "classic" finding of bilateral temporoparietal (TP) flow reductions as the sole abnormality occurred in only 28% of cases. Bilateral TP reductions accompanied by bilateral or unilateral frontal flow reductions were nearly as common (24%), and other patterns accounted for the other 48% of cases. more...
- Published
- 1993
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23. Brain blood flow SPECT in temporary balloon occlusion of carotid and intracerebral arteries.
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Mathews D, Walker BS, Purdy PD, Batjer H, Allen BC, Eckard DA, Devous MD Sr, and Bonte FJ
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Brain diagnostic imaging, Female, Humans, Male, Middle Aged, Time Factors, Brain blood supply, Carotid Arteries, Cerebral Arteries, Cerebrovascular Circulation physiology, Embolization, Therapeutic, Tomography, Emission-Computed, Single-Photon
- Abstract
It is important to determine preoperatively which patients can tolerate permanent occlusion of a cervical internal carotid or cerebral artery when such a procedure may be necessary to treat cerebrovascular or neoplastic lesions. Here we report our experience in combining temporary intra-arterial balloon occlusion with concomitant cerebral blood flow imaging in preoperative evaluation of such patients. Forty-two patients with a variety of cerebrovascular and neoplastic lesions underwent trial balloon occlusion of an internal carotid or intracerebral artery. Eight patients developed both neurologic symptoms as well as brain perfusion defects during trial occlusion. Nine others developed only perfusion defects. The remainder were asymptomatic and had negative scans. Brain blood flow imaging during intra-arterial balloon occlusion identified 17 patients potentially at risk for developing postsurgical ischemic deficits. Treatment alternatives to acute arterial sacrifice were developed for these patients. more...
- Published
- 1993
24. People in nuclear medicine: an interview with Fred Bonte.
- Author
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Bonte FJ
- Subjects
- Humans, United States, Nuclear Medicine trends, Radionuclide Imaging trends
- Published
- 1993
25. Brain blood flow in the dementias: SPECT with histopathologic correlation.
- Author
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Bonte FJ, Tintner R, Weiner MF, Bigio EH, and White CL 3rd
- Subjects
- Adult, Aged, Alzheimer Disease diagnostic imaging, Alzheimer Disease pathology, Brain pathology, Dementia pathology, Female, Humans, Male, Middle Aged, Brain blood supply, Dementia diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Abstract
Single photon emission computed tomography (SPECT) of regional cerebral blood flow (RCBF) has been employed experimentally in the assessment of patients with dementia. The standard with which the SPECT diagnosis has been compared previously has been the initial clinical diagnosis. Recognizing that histopathologic diagnosis would be a more reliable standard, the authors compared SPECT diagnoses and clinical diagnoses with histopathologic diagnoses in a series of 18 patients who had been referred by the Alzheimer Disease Research Center. SPECT RCBF studies were carried out prospectively in 15 patients with an inhaled xenon-133 SPECT technique and in three patients with technetium-99m hexamethyl-propylene-amine oxime and triple-camera-scanner SPECT. When compared with histopathologic diagnosis, clinical diagnosis was correct in 15 of 18 patients; visual scanning diagnosis, in 13 of 18; and Xe-133-SPECT diagnosis based on quantitative ratios in regions of interest, in 14 of 15 (13 of 13 with Alzheimer disease). more...
- Published
- 1993
- Full Text
- View/download PDF
26. Temporary balloon occlusion of the carotid artery combined with brain blood flow imaging as a test to predict tolerance prior to permanent carotid sacrifice.
- Author
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Eckard DA, Purdy PD, and Bonte FJ
- Subjects
- Adolescent, Aged, Brain blood supply, Female, Humans, Middle Aged, Time Factors, Tomography, Emission-Computed, Single-Photon, Brain diagnostic imaging, Carotid Artery, Internal physiology, Cerebrovascular Circulation, Embolization, Therapeutic
- Abstract
Purpose: To describe the technique of using SPECT brain blood flow imaging to identify patients at risk for having strokes after balloon or surgical ligation of an internal carotid artery., Patients and Methods: 29 patients underwent temporary balloon occlusion of the internal carotid artery and blood flow imaging studies were obtained prior to sacrifice of the vessel; 11 internal carotid arteries were indeed sacrificed and form the basis of our study. Follow-up of these patients ranged from 3 to 65 days., Results: Three groups emerged: group I, patients with symptoms during occlusion and an abnormal blood flow study (one patient); group II, patients with no symptoms during the occlusion but with an unequivocally abnormal blood flow study (two patients); group III, patients without symptoms during occlusion and a normal or slightly abnormal blood flow study (eight patients)., Conclusion: Carotid sacrifice without initial and temporary balloon occlusion is unnecessarily risky. Imaging of blood flow in the brains of these patients can further improve the safety of occlusion procedures in the internal carotid artery. more...
- Published
- 1992
27. The skeleton in congenital, generalized lipodystrophy: evaluation using whole-body radiographic surveys, magnetic resonance imaging and technetium-99m bone scintigraphy.
- Author
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Fleckenstein JL, Garg A, Bonte FJ, Vuitch MF, and Peshock RM
- Subjects
- Adult, Bone Diseases etiology, Contrast Media, Female, Gadolinium, Gadolinium DTPA, Humans, Lipodystrophy congenital, Lipodystrophy genetics, Magnetic Resonance Imaging, Organometallic Compounds, Pentetic Acid, Technetium Tc 99m Medronate, Bone Diseases diagnosis, Bone and Bones pathology, Lipodystrophy complications
- Abstract
Congenital generalized lipodystrophy (CGL) is a rare genetic disease characterized by the absence of body fat from birth. Focal bone lesions have also been reported, but their pathophysiology is poorly understood. To characterize skeletal abnormalities further in 3 patients with CGL, we employed whole-body radiographic skeletal surveys, magnetic resonance imaging (MRI, including gadolinium enhancement), and triple phase technetium-99m methylene diphosphonate bone scintigraphy. Radiographs showed numerous focal lesions within the long bones, as described in other reports. MRI showed that the entire marrow space of the long bones was abnormal and was characterized, at least in part, by the absence of marrow fat. Prolonged T1 and T2 times and marked gadolinium enhancement were observed in radiographically normal-appearing long bone. Radiographically lytic lesions occasionally demonstrated fluid-fluid levels on MRI and enhanced peripherally after gadolinium infusion. Bone scintigraphy findings such as periarticular hyperemia were relative subtle. We conclude that the appendicular skeleton of patients with CGL is diffusely abnormal and is predisposed to focal osteolysis and cyst formation. more...
- Published
- 1992
- Full Text
- View/download PDF
28. Differential diagnosis of bacterial myositis in AIDS: evaluation with MR imaging.
- Author
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Fleckenstein JL, Burns DK, Murphy FK, Jayson HT, and Bonte FJ
- Subjects
- Adult, Bacterial Infections complications, Diagnosis, Differential, Humans, Middle Aged, Myositis complications, Myositis microbiology, Retrospective Studies, Acquired Immunodeficiency Syndrome complications, Bacterial Infections diagnosis, Magnetic Resonance Imaging, Muscles pathology, Myositis diagnosis
- Abstract
Magnetic resonance (MR) imaging was used to assess for the presence of bacterial myositis, rare outside the tropics, in 13 patients with either the acquired immunodeficiency syndrome (AIDS) (n = 11) or positive results of serologic tests for the human immunodeficiency virus but without other evidence of AIDS (n = 2). Bacterial myositis was diagnosed in six patients: in five it was caused by pyogenic bacteria, and in the other, by Mycobacterium tuberculosis; in each patient, little or no subcutaneous tissue alteration occurred. On T1-weighted images in three patients, muscle abscesses showed a rim of increased signal intensity corresponding to margins between drainable pus and edematous muscle. Subcutaneous tissues appeared normal in patients with bacterial myositis but was not in the others, in whom muscle abnormalities tended to be less prominent. The latter group included patients with lymphoma (n = 1), Kaposi sarcoma (n = 2), and carbunculosis (n = 1), and three patients in whom no diagnosis was made; lymphedema was presumed to account for imaging abnormalities in four of the latter group. more...
- Published
- 1991
- Full Text
- View/download PDF
29. Single photon tomography in Alzheimer's disease and the dementias.
- Author
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Bonte FJ, Hom J, Tintner R, and Weiner MF
- Subjects
- Alzheimer Disease physiopathology, Cerebrovascular Circulation physiology, Dementia physiopathology, Humans, Alzheimer Disease diagnostic imaging, Dementia diagnostic imaging, Tomography, Emission-Computed, Single-Photon
- Abstract
Measurements of brain blood flow has evolved over the past 50 years, and during the latter half of that time radionuclide techniques have been used to study this important function. Using Xenon 133 and scintillation multiprobe systems, several teams of investigators measured regional cerebral blood flow (rCBF), and noted that under many circumstances it could be equated with local brain physiological activity. The dementias were investigated using the scintillation multiprobe method, and posterior flow deficits were described in patients who were thought to have Alzheimer's disease. The multiprobe technique gave way first to planar, and then tomographic imaging, with initial favorable results achieved by positron emission tomography (PET). Soon investigators learned to measure rCBF with single-photon emission computed tomography (SPECT) using high-sensitivity systems and 133Xe as a tracer, or high-resolution systems with 123I-iodoamphetamine (IMP), and later, 99mTc-HMPAO. Three-dimensional tomographic imaging shows to advantage the flow patterns that characterize Alzheimer's disease, with rCBF reductions in temporal, parietal, and sometimes frontal areas, as opposed to randomly distributed deficits in multiinfarct dementia, reduced frontal flow in entities such as Pick's disease, and others. Herein we will review our own experience with high-sensitivity rCBF SPECT in 119 patients with dementia, and with high-resolution SPECT, using a new, three-camera scanner and 99mTc-HMPAO in an additional 39 patients. SPECT rCBF study of patients with dementia and Alzheimer's disease, will aid in separating patients with untreatable Alzheimer's from those patients who may have treatable causes of dementia, and will be useful in evaluating experimental drugs for the treatment of Alzheimer's disease. more...
- Published
- 1990
- Full Text
- View/download PDF
30. Hypofrontality and cognitive impairment in schizophrenia: dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function.
- Author
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Paulman RG, Devous MD Sr, Gregory RR, Herman JH, Jennings L, Bonte FJ, Nasrallah HA, and Raese JD
- Subjects
- Adult, Carbon Dioxide physiology, Humans, Male, Middle Aged, Observer Variation, Psychological Tests, Regional Blood Flow, Tomography, Emission-Computed, Single-Photon, Cognition Disorders physiopathology, Frontal Lobe blood supply, Schizophrenia physiopathology, Schizophrenia, Paranoid physiopathology, Temporal Lobe blood supply
- Abstract
Regional cerebral blood flow (rCBF) was assessed in 40 chronic male schizophrenic patients (20 medicated, 20 unmedicated) and 31 matched normal controls with Dynamic Single-photon Emission Computed Tomography (D-SPECT). Blind analyses of normalized color-coded tomograms revealed significant bifrontal and bitemporal rCBF deficits in the patient group. Frontal flow deficits were most prominent in paranoid patients (n = 21) and right temporal deficits were most prominent in nonparanoid patients (n = 19). These relative regional declines were observed within the context of significantly elevated hemispheric blood flow in schizophrenics compared with controls. Reduced left frontal rCBF was associated with neuropsychological impairment on the Wisconsin Card Sorting Test and Luria-Nebraska Battery. Increased hemispheric CBF was correlated with the presence of positive schizophrenic symptoms. Medication status was unrelated to rCBF. These findings demonstrate that hypofrontality has important implications for cognitive function in some schizophrenic individuals. more...
- Published
- 1990
- Full Text
- View/download PDF
31. Recent advances in nuclear cardiology. 1. "Hot-spot" and "cold-spot" myocardial scintigraphy.
- Author
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Willerson JT, Lewis SE, Buja LM, Bonte FJ, and Parkey RW
- Subjects
- Coronary Disease diagnostic imaging, Diphosphates, Humans, Myocardial Revascularization, Perfusion, Potassium Radioisotopes, Radionuclide Imaging, Technetium, Technetium Tc 99m Pyrophosphate, Thallium, Heart diagnostic imaging, Myocardial Infarction diagnostic imaging
- Abstract
Nuclear cardiology is a comparatively new field of cardiovascular medicine in which technologic advances have provided relatively noninvasive means of evaluating cardiovascular abnormalities. The purpose of this two-part review is to emphasize some important recent advances and to place in perspective the advantages and disadvantages of those new techniques that are particularly useful clinically. more...
- Published
- 1981
- Full Text
- View/download PDF
32. Acute subendocardial myocardial infarction in patients. Its detection by Technetium 99-m stannous pyrophosphate myocardial scintigrams.
- Author
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Willerson JT, Parkey RW, Bonte FJ, Meyer SL, and Stokely EM
- Subjects
- Acute Disease, Aged, Diphosphates, Electrocardiography, Endocardium, Female, Humans, Male, Middle Aged, Radionuclide Imaging, Myocardial Infarction diagnosis, Technetium
- Abstract
Eighty-eight patients admitted to a coronary care unit with chest pain of varying etiology but without ECG evidence of an acute transmural myocardial infarction had myocardial scintigrams using technetium-99m stannour pyrophosphate (99m-Tc-PYP). Seventeen of these patients had ECG and enzymatic evidence suggestive of acute subendocardial myocardial infarction. In each of these the scintigrams were postivie demonstrating increased 99m-Tc-PYP uptake either in a faintly but diffusely positive pattern or in a well-localized strongly positive one. The remaining 71 patients did not evolve ECG or enzymatic evidence of acute myocardial infarction. In each of these patients the myocardial scintigram was negative. Thus 99m-Tc-PYP myocardial scintigrams are capable of identifying the presence of acute subendocardial myocardial infarction in patients. The absolute frequency with shich subendocardial myocardial infarction can be recognized utilizing this technique will have to be established in a larger number of patients in the future. more...
- Published
- 1975
- Full Text
- View/download PDF
33. Experimental pertechnetate mammography.
- Author
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Villarreal RL, Parkey RW, and Bonte FJ
- Subjects
- Adult, Aged, Breast Neoplasms diagnostic imaging, False Negative Reactions, False Positive Reactions, Female, Humans, Male, Mammography, Breast Neoplasms diagnosis, Radionuclide Imaging, Technetium
- Published
- 1974
- Full Text
- View/download PDF
34. Technetium stannous pyrophosphate myocardial scintigraphy for diagnosing and localizing acute myocardial infarcts.
- Author
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Willerson JT, Parkey RW, Bonte FJ, Stokely EM, and Buja LM
- Subjects
- Humans, Diphosphates, Myocardial Infarction diagnosis, Radionuclide Imaging, Technetium, Tin
- Published
- 1976
35. Antihypertensive therapy in the elderly. Effects on blood pressure and cerebral blood flow.
- Author
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Ram CV, Meese R, Kaplan NM, Devous MD Sr, Bonte FJ, Forland SC, and Cutler RE
- Subjects
- Aged, Heart Rate drug effects, Humans, Hypertension metabolism, Middle Aged, Blood Pressure drug effects, Cerebrovascular Circulation drug effects, Hypertension drug therapy, Prazosin therapeutic use
- Abstract
Antihypertensive therapy significantly reduces cardiovascular morbidity and mortality in the rapidly growing population of elderly patients. However, the desire to treat more of these patients is dampened by the concern that a reduction in blood pressure may compromise cerebral blood flow, causing untoward consequences. This study evaluated the therapeutic effect of titrated doses of prazosin, an alpha-adrenergic blocking agent, on systemic blood pressure and cerebral blood flow in elderly patients with chronic stable hypertension. Prazosin alone or co-administered with hydrochlorothiazide significantly lowered mean systolic and diastolic blood pressures in 31 elderly hypertensive patients. At the same time, however, there was no significant change in cerebral blood flow, which was measured in eight patients. Neither harmful biochemical changes nor treatment-related adverse effects were observed in any patients. Prazosin therapy alone or in combination with low-dose diuretic therapy was effective in the treatment of hypertension in this elderly population. Furthermore, blood pressure reduction with prazosin therapy was accomplished without compromising cerebral blood flow and without unfavorably altering lipid profiles. more...
- Published
- 1987
- Full Text
- View/download PDF
36. Clinicopathologic findings in 52 patients studied by technetium-99m stannous pyrophosphate myocardial scintigraphy.
- Author
-
Poliner LR, Buja LM, Parkey RW, Bonte FJ, and Willerson JT
- Subjects
- Acute Disease, Angina Pectoris diagnostic imaging, Angina Pectoris pathology, Coronary Disease pathology, Diagnosis, Differential, Evaluation Studies as Topic, Humans, Myocardial Infarction diagnostic imaging, Myocardial Infarction pathology, Necrosis, Radionuclide Imaging, Technetium, Time Factors, Tin Polyphosphates, Coronary Disease diagnostic imaging, Heart diagnostic imaging, Myocardium pathology
- Abstract
Scintigraphic, clinical and pathological findings were correlated in 52 patients studied by technetium-99m stannous pyrophosphate (99mTc-PYP) myocardial scintigraphy before death or surgical resection of myocardium. Fifty-nine clinical events were studied with scintigraphy in the 52 patients; 41 of the 59 were associated with one or more abnormal 99mTc-PYP studies and 18 with normal 99mTc-PYP scintigrams. Myocardial scintigrams were positive in 29 of 31 cases with clinicopathological evidence of a corresponding discrete, grossly obvious acute myocardial infarct, including 16 of 16 transmural myocardial infarcts and 13 of 15 subendocardial infarcts. In 16 of 18 cases, negative myocardial scintigrams correlated with the absence of acute myocardial infarction determined by clinicopathological evidence. In two cases small subendocardial infarcts (less than 3 g) were not detected by 99mTc-PYP myocardial scintigraphy. Of the 12 additional instances of positive 99mTc-PYP myocardial scintigrams, five were associated with clinical unstable angina pectoris and seven were in the category of persistently positive scintigrams, since the scans were obtained 2.5 months or longer after proven or suspected acute myocardial infarcts. In all 12 instances, the positive 99mTc-PYP scintigrams were associated with evidence of multifocal irreversible myocardial damage consisting of myocytolysis, coagulation necrosis and/or fibrosis, and the histological age of the lesions was compatible with acute injury corresponding to the time of scintigraphy. The findings indicate that a positive 99mTc-PYP myocardial scintigram is a sensitive indicator of significant myocardial injury which may occur as confluent coagulation necrosis corresponding to clinical acute myocardial infarction, or as multifocal coagulation necrosis or myocytolysis associated with unstable angina pectoris or recurrent ischemic heart disease, especially after previous infarctions. more...
- Published
- 1979
- Full Text
- View/download PDF
37. Techniques for sizing myocardial infarction.
- Author
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Datz FL, Lewis SE, Stokely EM, Buja LM, Bonte FJ, Parkey RW, and Willerson JT
- Subjects
- Animals, Creatine Kinase blood, Dogs, Echocardiography, Electrocardiography, Humans, Myocardial Infarction diagnostic imaging, Necrosis, Radionuclide Imaging, Technetium, Tin Polyphosphates, Tomography, X-Ray Computed, Myocardial Infarction diagnosis, Technetium Tc 99m Pyrophosphate
- Published
- 1981
38. Cerebral blood flow changes during sodium-lactate-induced panic attacks.
- Author
-
Stewart RS, Devous MD Sr, Rush AJ, Lane L, and Bonte FJ
- Subjects
- Adult, Anxiety Disorders physiopathology, Brain diagnostic imaging, Cerebral Cortex blood supply, Female, Humans, Infusions, Intravenous, Lactic Acid, Male, Regional Blood Flow, Tomography, Emission-Computed, Xenon Radioisotopes, Anxiety Disorders chemically induced, Brain blood supply, Fear, Lactates administration & dosage, Panic
- Abstract
Dynamic single-photon emission computed axial tomography (CAT) with inhaled xenon-133 was used to measure regional cerebral blood flow in 10 drug-free patients with DSM-III-diagnosed panic disorder and in five normal control subjects. All subjects underwent regional cerebral blood flow studies while at rest or during normal saline infusion and during sodium lactate infusion. Six of the 10 patients and none of the control subjects experienced lactate-induced panic attacks. Lactate infusion markedly raised hemispheric blood flow levels in both control subjects and patients who did not panic. Patients who did panic experienced either a minimal increase or a decrease in hemispheric blood flow. more...
- Published
- 1988
- Full Text
- View/download PDF
39. Intracranial arteriovenous malformation: relationships between clinical and radiographic factors and ipsilateral steal severity.
- Author
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Batjer HH, Devous MD Sr, Seibert GB, Purdy PD, Ajmani AK, Delarosa M, and Bonte FJ
- Subjects
- Adult, Age Factors, Female, Humans, Hyperemia etiology, Intracranial Arteriovenous Malformations complications, Male, Middle Aged, Xenon Radioisotopes, Cerebral Angiography, Cerebrovascular Circulation, Functional Laterality physiology, Intracranial Arteriovenous Malformations diagnostic imaging, Tomography, Emission-Computed
- Abstract
Intracranial arteriovenous malformations (AVMs) are high flow shunts that may jeopardize the perfusion of adjacent tissue. Clinical and radiographic data from 62 patients were analyzed to determine their relationship to the severity of steal measured by single photon emission computed tomography (SPECT). The ipsilateral steal index [ISteal(i)] was determined by dividing regional cerebral blood flow (rCBF) values within hand-drawn regions of hypoperfusion in the ipsilateral hemisphere by total brain flow, which was calculated as the average rCBF of each hemisphere. Of the patients, 40% were less than 30 years of age, 45% were 30 to 50 years old, and 15% were over 50. Forty-eight per cent presented with hemorrhage and 34% presented with progressive deficits. There was angiographic steal in 37%, and postoperative hyperemic complications developed in 21%. All patients had ipsilateral regions of hypoperfusion. The ISteal(i) was less than 0.7 in 23 (37%), 0.7 to 0.8 in 20 (32%), and greater than 0.8 in 19 (31%). The ISteal(i) was significantly less severe in the patients over 50; 78% of these patients had an ISteal(i) of greater than 0.8 (P less than 0.01). A history of hemorrhage was associated with less severe steal than that in patients who had not bled (P = 0.088). Patients presenting with a history of progressive deficits had increased severity of steal compared with those without progressive deficits (P less than 0.05). A trend toward decreased severity of steal was noted in patients with unfavorable outcomes.(ABSTRACT TRUNCATED AT 250 WORDS) more...
- Published
- 1988
- Full Text
- View/download PDF
40. Pathophysiologic considerations and clinicopathological correlates of technetium-99m stannous pyrophosphate myocardial scintigraphy.
- Author
-
Willerson JT, Parkey RW, Bonte FJ, Lewis SE, Corbett J, and Buja LM
- Subjects
- Animals, Calcium metabolism, Coronary Disease diagnostic imaging, Coronary Disease pathology, Humans, Inclusion Bodies metabolism, Inclusion Bodies ultrastructure, Microscopy, Electron, Mitochondria, Heart metabolism, Mitochondria, Heart ultrastructure, Myocardial Infarction pathology, Myocardium pathology, Radionuclide Imaging, Heart diagnostic imaging, Myocardial Infarction diagnostic imaging, Polyphosphates, Technetium, Technetium Tc 99m Pyrophosphate, Tin Polyphosphates
- Abstract
99mTc-PYP myocardial scintigrams represent a means to detect and localize acute myocardial necrosis. These scintigrams are expected to be abnormal with acute myocardial infarcts of at least 3 grams in weight if serial imaging is utilized and proper attention to technique is provided. Any etiology of myocardial necrosis may produce abnormal 99mTc-PYP scintigrams if the damage is relatively localized and includes at least 3 grams of tissue. It is possible to accurately size acute anterior and anterolateral transmural myocardial infarcts using area or 2 dimensional measurements. Further development in imaging cameras and computer techniques allowing three dimensional reconstruction of myocardial infarcts with this and similar imaging techniques may allow relatively precise quantitation of other types of myocardial infarcts. The "doughnut" and "persistently abnormal" 99mTc-PYP scintigrams appear to have anatomic and prognostic significance at least in subsets of patients studied, but larger numbers of individuals need to be evaluated before final conclusions regarding their ultimate prognostic significance can be reached. more...
- Published
- 1980
- Full Text
- View/download PDF
41. Pathophysiology of "cold spot" and "hot spot" myocardial imaging agents used to detect ischemia or infarction.
- Author
-
Buja LM, Parkey RW, Bonte FJ, and Willerson JT
- Subjects
- Animals, Dogs, Heart Aneurysm pathology, Heart Ventricles diagnostic imaging, Heart Ventricles pathology, Humans, Krypton, Myocardial Infarction pathology, Myocardium ultrastructure, Potassium Radioisotopes, Technetium, Xenon Radioisotopes, Myocardial Infarction diagnostic imaging, Radionuclide Imaging methods
- Published
- 1979
42. Nuclear Medicine Pioneer Citation, 1976: David E. Kuhl, M.D.
- Author
-
Bonte FJ
- Subjects
- History, 20th Century, United States, Awards and Prizes, Nuclear Medicine
- Published
- 1976
43. The effect of acetazolamide on regional cerebral blood flow in normal human subjects as measured by single-photon emission computed tomography.
- Author
-
Bonte FJ, Devous MD, and Reisch JS
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Acetazolamide pharmacology, Brain diagnostic imaging, Cerebrovascular Circulation drug effects
- Abstract
Regional cerebral blood flow (rCBF) was evaluated in 15 normal, healthy volunteer control subjects before and after the administration of 1 g acetazolamide (ACZ) using a rotating four-detector single-photon emission computed tomograph (SPECT). ACZ, a carbonic anhydrase inhibitor, is a cerebral vasodilator. RCBF values in mL/minute/100 g were derived within eight cortical regions of interest (ROI), and from the whole slice as an expression of whole brain blood flow (WBF). ROI/WBF ratios were established for each ROI in each of the 15 subjects for both pre-ACZ and post-ACZ studies. ACZ produced a 30% +/- 17% increase in WBF. Studies were done in random order, with nine subjects undergoing the post-ACZ study first, and six the pre-ACZ, or baseline, study first. Statistical analysis showed no significant difference in any ROI that might be caused by sequence of test procedures. Ratios were then examined to determine whether rCBF elevation was proportionate in all ROI in all subjects. No significant difference was found in any ROI except for the left parietal, for which marginally significant change was identified. Subjects also were examined for possible age and sex differences in ACZ response, and no differences were found. more...
- Published
- 1988
- Full Text
- View/download PDF
44. Past, present and future of nuclear cardiology.
- Author
-
Bonte FJ, Parkey RW, and Willerson JT
- Subjects
- Cardiovascular Diseases diagnostic imaging, Cardiovascular System diagnostic imaging, History, 20th Century, Humans, Methods, Radionuclide Imaging, Cardiology history, Nuclear Medicine history
- Published
- 1979
45. Improvement in regional cerebral blood flow and cerebral vasoreactivity after extracranial-intracranial arterial bypass.
- Author
-
Batjer HH, Devous MD Sr, Purdy PD, Mickey B, Bonte FJ, and Samson D
- Subjects
- Aged, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases physiopathology, Carotid Artery, Internal diagnostic imaging, Carotid Artery, Internal physiopathology, Cerebral Angiography, Humans, Ligation, Male, Radionuclide Imaging, Carotid Artery Diseases surgery, Carotid Artery, Internal surgery, Cerebral Revascularization, Cerebrovascular Circulation
- Abstract
Regional cerebral blood flow was measured with xenon-133 inhalation single photon emission computed tomography in a patient who developed a neurological deficit after carotid ligation. Hemispheric hypoperfusion was noted in resting studies and impaired vasoreactivity was suggested by lack of symmetrical flow augmentation after acetazolamide administration. Because of progressive neurological deterioration, an extracranial-intracranial bypass was performed. After prompt neurological improvement, repeat cerebral blood flow measurements at 1 and 9 weeks postoperatively confirmed improvement in resting flow and vasoreactivity. It is possible that decreased cerebrovascular reserve implied by measurements of vasoreactivity can identify patients who will benefit from surgical revascularization. more...
- Published
- 1988
46. Brain blood flow by radioxenon tomography.
- Author
-
Stokely EM, Bonte FJ, Devous MD Sr, and Arora G
- Subjects
- Humans, Cerebrovascular Circulation, Tomography, Emission-Computed instrumentation, Xenon Radioisotopes
- Published
- 1988
47. Quantification of intracerebral steal in patients with arteriovenous malformation.
- Author
-
Homan RW, Devous MD Sr, Stokely EM, and Bonte FJ
- Subjects
- Adult, Arterial Occlusive Diseases physiopathology, Arteriovenous Malformations diagnosis, Humans, Male, Middle Aged, Tomography, Emission-Computed, Xenon Radioisotopes, Arteriovenous Malformations physiopathology, Cerebrovascular Circulation
- Abstract
Eleven patients with angiographically and/or pathologically proved arteriovenous malformations (AVMs) were studied using dynamic, single-photon-emission computed tomography (DSPECT). Quantification of regional cerebral blood flow in structurally normal areas remote from the AVM disclosed areas of decreased flow compared with normal controls in eight of 11 patients examined. Areas of hypoperfusion correlated with altered function as manifested by epileptogenic foci and impaired cognitive function. Dynamic, single-photon-emission computed tomography provides a noninvasive technique to monitor quantitatively hemodynamic changes associated with AVMs. Our findings suggest that such changes are present in the majority of patients with AVMs and that they may be clinically significant. The potential application of regional cerebral blood flow imaging by DSPECT in the management of patients with AVMs is discussed. more...
- Published
- 1986
- Full Text
- View/download PDF
48. Pathophysiology of technetium-99m stannous pyrophosphate and thallium-201 scintigraphy of acute anterior myocardial infarcts in dogs.
- Author
-
Buja LM, Parkey RW, Stokely EM, Bonte FJ, and Willerson JT
- Subjects
- Acute Disease, Animals, Diphosphates metabolism, Dogs, Iodine Radioisotopes metabolism, Myocardial Infarction metabolism, Myocardial Infarction pathology, Radioisotopes, Myocardial Infarction diagnosis, Radionuclide Imaging, Technetium metabolism, Thallium metabolism
- Abstract
In 17 dogs with acute myocardial infarcts produced by ligation of the proximal left anterior descending coronary artery, a comparative study was made of myocardial scintigrams obtained with technetium-99m stannous pyrophosphate (99mTc-PYP) and thallium-201 (201T1), tissue levels of 99mTc-PYP and 201T1 uptake, histopathologic alterations, and regional myocardial perfusion measured with radioactive microspheres. 9 of the 10 hearts examined histologically had transmural infarcts with outer peripheral, inner peripheral, and central zones characterized by distinctive histopathologic features. A progressive reduction in myocardial blood flow was demonstrated between normal myocardium and the centers of the infarcts, and correlated well with progressive reduction in 201T1 upatke in the same regions. Marked 99mTc-PYP concentration occurred in areas with partial to homogeneous myocardial necrosis and residual perfusion located in the outer peripheral regions of the infarcts. The latter areas also were characterized by the presence of muscle cell calcification. The patterns of distribution of 99mTc-PYP and 201T1 explained the filling defects on 201T1 myocardial scintigrams and the doughnut patterns on 99mTc-PYP myocardial scintigrams in dogs with transmural infarcts. One dog with a subendocardial infarct had a small homogeneous area of activity on the 99mTc-PYP myocardial scintigram, and showed marked uptake of 99mTc-PYP in subendocardial areas of extensive necrosis and calcification still receiving some coronary perfusion. Thus, the data indicate that the status of regional myocardial perfusion is a key determinant for the occurrence of distinctive patterns of myocardial necrosis and for the scintigraphic detection of acute myocardial infarcts with 99mTc-PYP and 201T1. more...
- Published
- 1976
- Full Text
- View/download PDF
49. Technetium-99m stannous pyrophosphate "hot spot" imaging to detect acute myocardial infarcts.
- Author
-
Willerson JT, Parkey RW, Buja LM, and Bonte FJ
- Subjects
- Animals, Dogs, Humans, Myocardial Infarction pathology, Necrosis, Time Factors, Myocardial Infarction diagnostic imaging, Polyphosphates, Radionuclide Imaging methods, Technetium, Tin Polyphosphates
- Published
- 1979
50. Measurement of myocardial blood flow.
- Author
-
Parkey RW, Bonte FJ, Stokely EM, Curry GC, and Willerson JT
- Subjects
- Absorptiometry, Photon, Cesium Radioisotopes, Fatty Acids, Humans, Indicator Dilution Techniques, Iodine Radioisotopes, Krypton, Microspheres, Nitrogen Radioisotopes, Phosphates, Physical Exertion, Potassium Radioisotopes, Radioisotopes, Rheology, Rubidium, Serum Albumin, Radio-Iodinated, Technetium, Tetracycline, Thallium, Ultrasonography, Xenon Radioisotopes, Coronary Circulation, Coronary Disease diagnosis, Radioisotope Dilution Technique, Radionuclide Imaging
- Abstract
This paper represents a review of the recent literature on techniques to measure myocardial blood flow in man. A short discussion on flow meters in followed by a more detailed discussion of the radionuclide techniques used to measure myocardial blood flow. The radionuclide techniques are discussed in two groups: (1) qualitative measurement of blood flow using static images; and (2) quantitative measurements of blood flow using diffusible substances that actively enter the cell, radioactive labeled particles, and radioactive diffusible gases. more...
- Published
- 1975
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