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1. The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus

Author

Langedijk, Annefleur C., Vrancken, Bram, Lebbink, Robert Jan, Wilkins, Deidre, Kelly, Elizabeth J., Baraldi, Eugenio, Mascareñas de Los Santos, Abiel Homero, Danilenko, Daria M., Choi, Eun Hwa, Palomino, María Angélica, Chi, Hsin, Keller, Christian, Cohen, Robert, Papenburg, Jesse, Pernica, Jeffrey, Greenough, Anne, Richmond, Peter, Martinón-Torres, Federico, Heikkinen, Terho, Stein, Renato T., Hosoya, Mitsuaki, Nunes, Marta C., Verwey, Charl, Evers, Anouk, Kragten-Tabatabaie, Leyla, Suchard, Marc A., Kosakovsky Pond, Sergei L., Poletto, Chiara, Colizza, Vittoria, Lemey, Philippe, and Bont, Louis J.

Published
2024
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3. Respiratory syncytial virus infection among children younger than 2 years admitted to a paediatric intensive care unit with extended severe acute respiratory infection in ten Gavi-eligible countries: the RSV GOLD—ICU Network study

Author

Abdelrahman, Dina N, Abdullahi, Fatima L, Abdu-Raheem, Fadlulai, Abicher, Lynda T, Adelaiye, Hamdalla, Badjie, Ansumana, Bah, Abdou, Bista, Krishna P, Bont, Louis J, Boom, Trisja T, Buck, W Chris, Cáceres Avila, Milka Amanda, Chapagain, Ram Hari, Cianci, Daniela, Deroncelay, Alexandra, Dor, Vanessa, Ekotto, Karen, Enan, Khalid A, Eposse, Charlotte, Fouobang, Esquivel, Gai, Abdou, Garba, Abdoulie, Garba, Maria A, Gautier, Jacqueline, Giwa, Fatima J, Godfrey, Evance K, Goka, Bamenla Quarm, Jaiteh, Musa, Jallow, Mariama, Jallow, Alasana, Joof, Sheikh, Joshi, Prakash, Kuti, Bankole P, Löwensteyn, Yvette N, Makalo, Lamin, Mandi, Henshaw, Manjate, Yara, Manjate, Elias, Matimbe, Izilda, Mazur, Natalie I, Medani, Safaa A, Mendy, Peter T, Muando, Valéria, Mussá, Tufária, Nair, Harish, Nyan, Ousman, Obodai, Evangeline, Olorukooba, Aira A, Osman, Kwabena Agyapong, Osman, Khalid, Peñarrieta Echenique, Daisy Luisa Fátima, Pérales, Jose Gareca, Rave, Neele, Said, Yasser Habresh, Shaaban, Farina L, Sharma, Arun K, Shoo, Aika A, Shrestha, Rupesh, Sinussene, Cristina, Tahibo, Afshan, Willemsen, Joukje E, van Woensel, Job BM, Zavale, Farida, and van Zoggel, Hanneke JAA

Published
2024
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6. Age-specific SARS-CoV-2 transmission differed from human rhinovirus in households during the early COVID-19 pandemic

Author

Boom, Trisja T., de Hoog, Marieke L.A., Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie D., Fourie, Elandri, Sluiter-Post, Judith G.C., Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Sanders, Elisabeth A.M., Eggink, Dirk, Reusken, Chantal, Bont, Louis J., Wildenbeest, Joanne G., van Houten, Marlies A., Duijts, Liesbeth, and Bruijning-Verhagen, Patricia C.J.L.

Published
2024
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9. Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

Author

Arruda, Eurico, Baillie, Vicky L, Chong, Debora, Crow, Rowena, Filho, Nelson Rosário, Laubscher, Marius, Madhi, Shabir A, Mrcela, Dina, Ramilo, Octavio, Roje, Damir, Stein, Renato Tetelbom, Yung, Chee Fu, Wang, Xin, Li, You, Shi, Ting, Bont, Louis J, Chu, Helen Y, Zar, Heather J, Wahi-Singh, Bhanu, Ma, Yiming, Cong, Bingbing, Sharland, Emma, Riley, Richard D, Deng, Jikui, Figueras-Aloy, Josep, Heikkinen, Terho, Jones, Marcus H, Liese, Johannes G, Markić, Joško, Mejias, Asuncion, Nunes, Marta C, Resch, Bernhard, Satav, Ashish, Yeo, Kee Thai, Simões, Eric A F, and Nair, Harish

Published
2024
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10. Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trial

Author

Nibbelke, Elisabeth E., Buiteman, Brigitte, Rave, Neele, Putten, Marlies Vermaas-van, Smit-Kleinlugtenbeld, Elly A., de Lege-Korstanje, Jacqueline P., Peetsold, Marieke G., Hulsmann, Anthon, van Gool, Sandy, Snepvangers, Yvonne, Colombijn, Max, Menelik, Negassi, de Crom, Stephanie, Semmekrot, Ben, de Waal, Wouter J., Okhuijsen, Eline, ten Tusscher, Gavin W., de Moor, Ronald A., Breukels, Mijke A., Lutterman, Claire, Tramper-Stranders, Gerdien A., Oudshoorn, Johanna H., Ritman, Astrid, von Lindern, Jeannette S., Dubbink-Verheij, Gerdina H., van den Berg, Maartje M., Wilsterman, Marlon E.F., Rietveld, Edwin, van Heel, Willemijn, de Grauw, Anne M., Croes, Femke, Doedens, Rienus A., van Onzenoort-Bokken, Lonneke, Meijssen, Clemens B., van Scherpenzeel-de Vries, Machteld, Hoekstra, Petra, van Rooij, Linda G.M., Boode, Willem-Pieter de, van Rossem, Maaike C., Sipkema, Petra, Jacobs, Monique A.M., van Houten, Marianne A., Kok-Wijesinha, Indrani, Vlieger, Arine M., Balemans, Walter, Plötz, Frans B., Reijmerink, Naomi, van Dorth, Stefan M., Heikens, Willem, Kuijpers, Anke G., Geesing, Christel, Delsing, Bas J.P., Aldenhoven, Mieke, Illy, Karoly, Hack, Eric, Groenendaal, Floris, Derksen, Nicole, Rengerink, Katrien Oude, Meeldijk, Jan, Ebskamp-van Raaij, Lysette, de Groot-Mijnes, Jolanda D.F., Schuurman, Rob, Mazur, Natalie I., Löwensteyn, Yvette N., Terstappen, Jonne, Leusen, Jeanette, Schobben, Fred, Cianci, Daniela, van de Ven, Peter M., Nierkens, Stefan, and Bont, Louis J.

Published
2023
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13. Nirsevimab binding-site conservation in respiratory syncytial virus fusion glycoprotein worldwide between 1956 and 2021: an analysis of observational study sequencing data

Author

Clement, Pascale, Gupta, Atul, Hashimoto, Koichi, Komissarova, Kseniya, Laubscher, Matt, Lumertz, Magali, Priante, Elena, Rivero-Calle, Irene, Wadia, Ushma, Yun, Ki Wook, Wilkins, Deidre, Langedijk, Annefleur C, Lebbink, Robert Jan, Morehouse, Christopher, Abram, Michael E, Ahani, Bahar, Aksyuk, Anastasia A, Baraldi, Eugenio, Brady, Tyler, Chen, Albert Tian, Chi, Hsin, Choi, Eun Hwa, Cohen, Robert, Danilenko, Daria M, Gopalakrishnan, Vancheswaran, Greenough, Anne, Heikkinen, Terho, Hosoya, Mitsuaki, Keller, Christian, Kelly, Elizabeth J, Kragten-Tabatabaie, Leyla, Martinón-Torres, Federico, de Los Santos, Abiel Homero Mascareñas, Nunes, Marta C, Palomino, María Angélica, Papenburg, Jesse, Pernica, Jeffrey M, Richmond, Peter, Stein, Renato T, Tuffy, Kevin M, Verwey, Charl, Esser, Mark T, Tabor, David E, and Bont, Louis J

Published
2023
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15. Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials

Author

Marie-Noelle Billard, Rengerink, Katrien Oude, Bont, Louis, Wildenbeest, Joanne, Nair, Harish, Campbell, Harry, Beutels, Philippe, Openshaw, Peter, Pollard, Andrew, Martinon-Torres, Federico, Heikkinen, Terho, Meijer, Adam, Fischer, Thea Kølsen, van den Berge, Maarten, Giaquinto, Carlo, Aerssens, Jeroen, Abram, Michael, Swanson, Kena, Demont, Clarisse, Gallichan, Scott, Kumar, Veena, Stoszek, Sonia, Molero, Eva, Billard, Marie-Noëlle, Bont, Louis J., McCracken, John P., and Oude Rengerink, Katrien

Published
2022
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16. Nasal DNA methylation at three CpG sites predicts childhood allergic disease

Author

van Breugel, Merlijn, Qi, Cancan, Xu, Zhongli, Pedersen, Casper-Emil T., Petoukhov, Ilya, Vonk, Judith M., Gehring, Ulrike, Berg, Marijn, Bügel, Marnix, Carpaij, Orestes A., Forno, Erick, Morin, Andréanne, Eliasen, Anders U., Jiang, Yale, van den Berge, Maarten, Nawijn, Martijn C., Li, Yang, Chen, Wei, Bont, Louis J., Bønnelykke, Klaus, Celedón, Juan C., Koppelman, Gerard H., and Xu, Cheng-Jian

Published
2022
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17. Inconsistent Increase in Age at Respiratory Syncytial Virus Hospitalization of Children Aged <2 Years During the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic: A Retrospective Multicenter Study in 4 European Countries.

Author

Harding, Eline R, Wildenbeest, Joanne G, Heikkinen, Terho, Dacosta-Urbieta, Ana, Martinón-Torres, Federico, Cunningham, Steve, Templeton, Kate, Bont, Louis J, Billard, Marie-Noëlle, and investigators, PROMISE

Subjects
SARS-CoV-2, RESPIRATORY syncytial virus, PEDIATRIC intensive care, COVID-19 pandemic, INTENSIVE care units
Abstract

Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disrupted respiratory syncytial virus (RSV) seasonality. To optimize the use and evaluation of RSV infant immunization strategies, monitoring changes in RSV epidemiology is essential. Methods Hospitalizations for acute respiratory infections (ARIs) and RSV-coded ARI in children <2 years were extracted in 4 European hospitals, according to predefined case definitions (International Classification of Diseases, Tenth Revision codes). Prepandemic RSV seasons (2017–2018 to 2019–2020) were compared to 2021–2022 and 2022–2023. Results In 2021–2022 and 2022–2023, the peak number of RSV hospitalizations was higher than prepandemic peaks after short periods of RSV circulation, and lower than prepandemic peaks after long periods of RSV circulation. A greater proportion of RSV hospitalizations occurred in children 1 to <2 years in 2021–2022 in the Netherlands (18% vs 9%, P =.04). No increase in age was observed elsewhere. High-risk children represented a greater proportion of RSV hospitalizations during the pandemic. The proportion of pediatric intensive care unit admissions did not increase. Conclusions A decrease in population immunity has been linked to older age at RSV hospitalization. We did not observe an increase in age in 3 of the 4 participating countries. Broad age categories may have prevented detecting an age shift. Monitoring RSV epidemiology is essential as Europe implements RSV immunization. [ABSTRACT FROM AUTHOR]

Published
2024
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18. The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

Author

Adeloye, Davies, Elneima, Omer, Daines, Luke, Poinasamy, Krisnah, Quint, Jennifer K, Walker, Samantha, Brightling, Chris E, Siddiqui, Salman, Hurst, John R, Chalmers, James D, Pfeffer, Paul E, Novotny, Petr, Drake, Thomas M, Abdollahi, Mohammad, Agarwal, Dhiraj, Al-Lehebi, Riyad, Barnes, Peter J, Bayry, Jagadeesh, Bonay, Marcel, Bont, Louis J, Bourdin, Arnaud, Brown, Thomas, Caramori, Gaetano, Chan, Amy Hai Yan, Dockrell, David H, Doe, Simon, Duckers, Jamie, D'Urzo, Anthony, Ekström, Magnus, Esteban, Cristóbal, Greene, Catherine M, Gupta, Atul, Ingram, Jennifer L, Khoo, Ee Ming, Ko, Fanny Wai San, Koppelman, Gerard H, Lipworth, Brian J, Lisspers, Karin, Loebinger, Michael, Lopez-Campos, Jose Luis, Maddocks, Matthew, Mannino, David, Martinez-Garcia, Miguel A, Mcnamara, Renae, Miravitlles, Marc, Ndarukwa, Pisirai, Pooler, Alison, Rhee, Chin Kook, Schwarz, Peter, Shaw, Dominick, Steiner, Michael, Tai, Andrew, Ulrik, Charlotte Suppli, Walker, Paul, Williams, Michelle C, Heaney, Liam G, Rudan, Igor, Sheikh, Aziz, and De Soyza, Anthony

Published
2021
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21. Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series

Author

Thorburn, Kentigern, Nunes, Marta, Chawana, Richard, Madhi, Shabir A., Vittuci, Anna C., Bassat, Quique, Bardají, Azucena, Goka, Edward, Roglić, Srđan, Paes, Bosco, Elliott, LouAnn, Oshitani, Hitoshi, Lupisan, Socorro, Gentile, Angela, Lucion, María Florencia, Spaeder, Michael C., Butt, Warwick, Thompson, Jenny, Mejias, Asuncion, Ramilo, Octavio, Fasce, Rodrigo A., Werner, Marta, Hijano, Diego R., Allison, Kim J., Pires, Márcia Rosane, de-Paris, Fernanda, Chakhunashvili, Giorgi, Karseladze, Irakli, Otieno, Grieven P., Nokes, D. James, Scheuerman, Oded, Prais, Dario, Amad, Mohammed Al, Serouri, Abdul Wahed Al, Ali, Asad, Yousafzai, Mohammad Tahir, Bruno, Alfredo, de Mora, Domenica, Ojeda, Jenny, Dbaibo, Ghassan, Hanna-Wakim, Rima, Papaevangelou, Vassiliki, Kartisouni, Elpiniki, Cohen, Cheryl, Walaza, Sibongile, Linssen, Rosalie S., Chi, Hsin, Eşki, Aykut, Demir, Esen, Saha, Senjuti, Saha, Samir K, Sochet, Anthony A., Teppa-Sanchez, Beatriz E., Ravindranath, Thyyar M., Baird, J. Scott, Morris, Shaun K., Wong, Waison, Breiman, Robert F., Gurley, Emily S., Arifeen, Shams El, Assefa, Nega, Scott, J. Anthony G., Onyango, Dickens, Kotloff, Karen L., Sow, Samba O., Mandomando, Inacio, Ogbuanu, Ikechukwu U., Jambai, Amara, Kendirli, Tanil, Botan, Edin, Rubio, Franco Díaz, Serra, Alberto, Martinez, Luis, Pedroso, Luis, Menta, Soledad, Pardo, Rosalba, Donoso, Alejandro, Mahmood, Syed Faisal, Khan, Naveera, Löwensteyn, Yvette N, Nair, Harish, Nunes, Marta C, van Roessel, Ichelle, Vernooij, Femke S, Willemsen, Joukje, Bont, Louis J, and Mazur, Natalie I

Published
2021
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22. Age-specific SARS-CoV-2 transmission differed from human rhinovirus in households during the early COVID-19 pandemic

Author

Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Methodologie, Child Health, Onderzoek, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, JC onderzoeksprogramma Infectieziekten, Boom, Trisja T, de Hoog, Marieke L A, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie D, Fourie, Elandri, Sluiter-Post, Judith G C, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Sanders, Elisabeth A M, Eggink, Dirk, Reusken, Chantal, Bont, Louis J, Wildenbeest, Joanne G, van Houten, Marlies A, Duijts, Liesbeth, Bruijning-Verhagen, Patricia C J L, Infection & Immunity, Epi Infectieziekten Team 1, JC onderzoeksprogramma Methodologie, Child Health, Onderzoek, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, JC onderzoeksprogramma Infectieziekten, Boom, Trisja T, de Hoog, Marieke L A, Westerhof, Ilse, Jaddoe, Vincent, Heuvelman, Valerie D, Fourie, Elandri, Sluiter-Post, Judith G C, Badoux, Paul, Euser, Sjoerd, Herpers, Bjorn, Sanders, Elisabeth A M, Eggink, Dirk, Reusken, Chantal, Bont, Louis J, Wildenbeest, Joanne G, van Houten, Marlies A, Duijts, Liesbeth, and Bruijning-Verhagen, Patricia C J L

Published
2024

23. Healthcare costs related to respiratory syncytial virus in paediatric intensive care units in the Netherlands: a nationwide prospective observational study (the BRICK study)

Author

Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, Intensive care patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, HEE, JC onderzoeksprogramma Methodologie, Phijffer, Emily W.E.M., Wildenbeest, Joanne G., Brouwer, Carole N.M., de Hoog, Matthijs, Kneyber, Martin C.J., Maebe, Sofie, Nusmeier, Anneliese, Riedijk, Maaike A., Wösten-van Asperen, Roelie M., van Woensel, Job B.M., Bont, Louis J., Frederix, Geert J.W., Infection & Immunity, Infectieziekten onderzoek2 (Wildenbeest), Infectieziekten patientenzorg, Child Health, Intensive care patientenzorg, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, HEE, JC onderzoeksprogramma Methodologie, Phijffer, Emily W.E.M., Wildenbeest, Joanne G., Brouwer, Carole N.M., de Hoog, Matthijs, Kneyber, Martin C.J., Maebe, Sofie, Nusmeier, Anneliese, Riedijk, Maaike A., Wösten-van Asperen, Roelie M., van Woensel, Job B.M., Bont, Louis J., and Frederix, Geert J.W.

Published
2024

24. Personalized Infant Risk Prediction for Severe Respiratory Syncytial Virus Lower Respiratory Tract Infection Requiring Intensive Care Unit Admission

Author

CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Child Health, Infection & Immunity, Snyder, Brittney M, Achten, Niek B, Gebretsadik, Tebeb, Wu, Pingsheng, Mitchel, Edward F, Escobar, Gabriel, Bont, Louis J, Hartert, Tina V, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Child Health, Infection & Immunity, Snyder, Brittney M, Achten, Niek B, Gebretsadik, Tebeb, Wu, Pingsheng, Mitchel, Edward F, Escobar, Gabriel, Bont, Louis J, and Hartert, Tina V

Published
2024

25. Natural variability of TRAIL, IP-10, and CRP in healthy adults - The 'HERACLES' study

Author

Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, MMB, CTI Bont, Zorg en O&O, Child Health, Langedijk, Annefleur C, Rengerink, Katrien Oude, Harding, Eline, Wensing, Annemarie, van Slooten, Rianne, Israeli, Yael, Rosenberg, Michal, Gottlieb, Tanya, Eden, Eran, Bont, Louis J, Infection & Immunity, Infectieziekten onderzoek1 (Bont), CTM & Statistical consultation, MMB, CTI Bont, Zorg en O&O, Child Health, Langedijk, Annefleur C, Rengerink, Katrien Oude, Harding, Eline, Wensing, Annemarie, van Slooten, Rianne, Israeli, Yael, Rosenberg, Michal, Gottlieb, Tanya, Eden, Eran, and Bont, Louis J

Published
2024

26. Long-term immunity after BNT162b2 mRNA COVID-19 vaccination in pediatric patients with cancer

Author

CTI Nierkens, Cancer, Infection & Immunity, PMC Medisch specialisten, SCT patientenzorg, Child Health, Regenerative Medicine and Stem Cells, CTI Research, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Schmidt, K. L.Juliëtte, Severeijns, Noortje R., Dautzenberg, Noël M.M., Hoogerbrugge, Peter M., Lindemans, Caroline A., Nierkens, Stefan, Smits, Gaby, van Binnendijk, Rob S., Fiocco, Marta, Bont, Louis J., Tissing, Wim J.E., CTI Nierkens, Cancer, Infection & Immunity, PMC Medisch specialisten, SCT patientenzorg, Child Health, Regenerative Medicine and Stem Cells, CTI Research, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Schmidt, K. L.Juliëtte, Severeijns, Noortje R., Dautzenberg, Noël M.M., Hoogerbrugge, Peter M., Lindemans, Caroline A., Nierkens, Stefan, Smits, Gaby, van Binnendijk, Rob S., Fiocco, Marta, Bont, Louis J., and Tissing, Wim J.E.

Published
2024

28. RSV neutralizing antibodies in dried blood

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Infectieziekten onderzoek2 (Wildenbeest), Zorg en O&O, Child Health, Terstappen, Jonne, Delemarre, Eveline M, Versnel, Anouk, White, Joleen T, Derrien-Colemyn, Alexandrine, Ruckwardt, Tracy J, Bont, Louis J, Mazur, Natalie I, Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Infectieziekten onderzoek2 (Wildenbeest), Zorg en O&O, Child Health, Terstappen, Jonne, Delemarre, Eveline M, Versnel, Anouk, White, Joleen T, Derrien-Colemyn, Alexandrine, Ruckwardt, Tracy J, Bont, Louis J, and Mazur, Natalie I

Published
2024

29. Healthcare costs related to respiratory syncytial virus in paediatric intensive care units in the Netherlands:a nationwide prospective observational study (the BRICK study)

Author

Phijffer, Emily W.E.M., Wildenbeest, Joanne G., Brouwer, Carole N.M., de Hoog, Matthijs, Kneyber, Martin C.J., Maebe, Sofie, Nusmeier, Anneliese, Riedijk, Maaike A., Wösten-van Asperen, Roelie M., van Woensel, Job B.M., Bont, Louis J., Frederix, Geert J.W., Phijffer, Emily W.E.M., Wildenbeest, Joanne G., Brouwer, Carole N.M., de Hoog, Matthijs, Kneyber, Martin C.J., Maebe, Sofie, Nusmeier, Anneliese, Riedijk, Maaike A., Wösten-van Asperen, Roelie M., van Woensel, Job B.M., Bont, Louis J., and Frederix, Geert J.W.

Abstract

Background: The implementation of the approved respiratory syncytial virus (RSV) preventive interventions in immunisation programmes is advancing rapidly. Insight into healthcare costs of RSV-related paediatric intensive care unit (PICU) admissions is lacking, but of great importance to evaluate the impact of implementation. Therefore, this study aimed to determine the total annual RSV-related paediatric intensive care healthcare costs in the Netherlands. Methods: A nationwide prospective, observational, multicenter study was performed from September 2021 until June 2023. The total annual RSV-related healthcare costs on PICUs in the Netherlands were calculated using RSV-related costs (subgroup I) and consequential costs (subgroup II and III). Subgroup I comprised all PICU admitted infants ≤12 months of age with laboratory-confirmed RSV infection. Subgroup II and III consisted of postponed elective PICU admissions and refused acute PICU admissions due to RSV-related lack of PICU capacity.Findings: A total of 424 infants with RSV-related PICU admission were included. Median age at PICU admission was 46 days (IQR 25–89). The median length of PICU admission was 5 days (IQR 3–8). The total RSV-related PICU costs are € 3,826,386 in 2021–2022, and € 3,183,888 in 2022–2023. Potential costs averted by RSV preventive interventions is € 1.9 to € 2.6 million depending on season, and the duration of protection. Interpretation: RSV-related PICU admissions cost €3.1 to €3.8 million in the Netherlands during one season. The introduction of new RSV preventive interventions into the Dutch immunisation programme will generate significant cost-savings on PICUs and decreases the admission burden of PICUs.

Published
2024

30. Characteristics of inpatient and outpatient respiratory syncytial virus mortality in Gavi-eligible countries

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Zorg en O&O, Child Health, CTI Computational Immunology Core, Willemsen, Joukje E., Vernooij, Femke S., Shaaban, Farina L., Chikoti, Chilufya, Bont, Louis J., Drylewicz, Julia, the RSV GOLD study group, Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Zorg en O&O, Child Health, CTI Computational Immunology Core, Willemsen, Joukje E., Vernooij, Femke S., Shaaban, Farina L., Chikoti, Chilufya, Bont, Louis J., Drylewicz, Julia, and the RSV GOLD study group

Published
2024

31. Clinical presentation and outcome of invasive mould disease in paediatric patients with acute lymphoblastic leukaemia

Author

MS Neonatologie, PMC Medisch specialisten, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Child Health, Infection & Immunity, Infectiezieken, Infectieziekten patientenzorg, Bury, Didi, Parmentier, Corline E.J., Tissing, Wim J.E., Pieters, Rob, Bont, Louis J., Brüggemann, Roger J., Wolfs, Tom F.W., MS Neonatologie, PMC Medisch specialisten, CTI Bont, Infectieziekten onderzoek1 (Bont), Zorg en O&O, Child Health, Infection & Immunity, Infectiezieken, Infectieziekten patientenzorg, Bury, Didi, Parmentier, Corline E.J., Tissing, Wim J.E., Pieters, Rob, Bont, Louis J., Brüggemann, Roger J., and Wolfs, Tom F.W.

Published
2024

32. Disagreement FDA and EMA on RSV Maternal Vaccination: Possible Consequence for Global Mortality

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Borghans, CTI Bont, Child Health, CTI Computational Immunology Core, Willemsen, Joukje E, Borghans, José A M, Bont, Louis J, Drylewicz, Julia, Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Borghans, CTI Bont, Child Health, CTI Computational Immunology Core, Willemsen, Joukje E, Borghans, José A M, Bont, Louis J, and Drylewicz, Julia

Published
2024

33. Outpatient respiratory syncytial virus infections and novel preventive interventions

Author

Infectieziekten onderzoek2 (Wildenbeest), Infection & Immunity, HAG Onderzoek, Child Health, Infectieziekten patientenzorg, Infectieziekten onderzoek1 (Bont), CTI Bont, Hak, Sarah F, Venekamp, Roderick P, Wildenbeest, Joanne G, Bont, Louis J, Infectieziekten onderzoek2 (Wildenbeest), Infection & Immunity, HAG Onderzoek, Child Health, Infectieziekten patientenzorg, Infectieziekten onderzoek1 (Bont), CTI Bont, Hak, Sarah F, Venekamp, Roderick P, Wildenbeest, Joanne G, and Bont, Louis J

Published
2024

34. Respiratory syncytial virus vaccination during pregnancy for improving infant outcomes

Author

Infectieziekten onderzoek2 (Wildenbeest), MS Verloskunde, Infection & Immunity, Infectieziekten patientenzorg, Child Health, CTI Bont, Infectieziekten onderzoek1 (Bont), Epidemiology & Health Economics, Data Science & Biostatistiek, RWE/Causal inference, Geboortecentrum voorzitterschap, Phijffer, Emily, de Bruin, Odette, Wildenbeest, Joanne G., Bont, Louis J., Sturkenboom, Miriam C.J.M., Van der Maas, Nicoline A.T., Ahmadizar, Fariba, Bloemenkamp, Kitty W.M., Infectieziekten onderzoek2 (Wildenbeest), MS Verloskunde, Infection & Immunity, Infectieziekten patientenzorg, Child Health, CTI Bont, Infectieziekten onderzoek1 (Bont), Epidemiology & Health Economics, Data Science & Biostatistiek, RWE/Causal inference, Geboortecentrum voorzitterschap, Phijffer, Emily, de Bruin, Odette, Wildenbeest, Joanne G., Bont, Louis J., Sturkenboom, Miriam C.J.M., Van der Maas, Nicoline A.T., Ahmadizar, Fariba, and Bloemenkamp, Kitty W.M.

Published
2024

35. Personalized Infant Risk Prediction for Severe Respiratory Syncytial Virus Lower Respiratory Tract Infection Requiring Intensive Care Unit Admission

Author

Snyder, Brittney M., Achten, Niek B., Gebretsadik, Tebeb, Wu, Pingsheng, Mitchel, Edward F., Escobar, Gabriel, Bont, Louis J., Hartert, Tina V., Snyder, Brittney M., Achten, Niek B., Gebretsadik, Tebeb, Wu, Pingsheng, Mitchel, Edward F., Escobar, Gabriel, Bont, Louis J., and Hartert, Tina V.

Abstract

Background:Currently, there are no available tools to identify infants at the highest risk of significant morbidity and mortality from respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) who would benefit most from RSV prevention products. The objective was to develop and internally validate a personalized risk prediction tool for use among all newborns that uses readily available birth/postnatal data to predict RSV LRTI requiring intensive care unit (ICU) admission. Methods:We conducted a population-based birth cohort study of infants born from 1995 to 2007, insured by the Tennessee Medicaid Program, and who did not receive RSV immunoprophylaxis during the first year of life. The primary outcome was severe RSV LRTI requiring ICU admission during the first year of life. We built a multivariable logistic regression model including demographic and clinical variables available at or shortly after birth to predict the primary outcome. Results:In a population-based sample of 429 365 infants, 713 (0.2%) had severe RSV LRTI requiring ICU admission. The median age of admission was 66 days (interquartile range, 37–120). Our tool, including 19 variables, demonstrated good predictive accuracy (area under the curve, 0.78; 95% confidence interval, 0.77-0.80) and identified infants who did not qualify for palivizumab, based on American Academy of Pediatrics guidelines, but had higher predicted risk levels than infants who qualified (27% of noneligible infants with >0.16% predicted probabilities [lower quartile for eligible infants]). Conclusions:We developed a personalized tool that identified infants at increased risk for severe RSV LRTI requiring ICU admission, expected to benefit most from immunoprophylaxis.

Published
2024

36. RSV Neutralizing Antibodies in Dried Blood.

Author

Terstappen, Jonne, Delemarre, Eveline M, Versnel, Anouk, White, Joleen T, Derrien-Colemyn, Alexandrine, Ruckwardt, Tracy J, Bont, Louis J, and Mazur, Natalie I

Subjects
CLINICAL trial registries, RESPIRATORY syncytial virus, VIRAL vaccines, BLOOD sampling, MONOCLONAL antibodies
Abstract

Background The key correlate of protection of respiratory syncytial virus (RSV) vaccines and monoclonal antibodies (mAbs) is virus neutralization, measured via sera obtained through venipuncture. Dried blood obtained with a finger prick can simplify acquisition, processing, storage, and transport in trials and thereby reduce costs. In this study, we validate an assay to measure RSV neutralization in dried capillary blood. Methods Functional antibodies were compared between matched serum and dried blood samples from a phase 1 trial with RSM01, an investigational anti-RSV prefusion F mAb. Hep-2 cells were infected with a serial dilution of sample-virus mixture by using RSV-A2-mKate to determine the half-maximal inhibitory concentration. Stability of dried blood was evaluated over time and during temperature stress. Results Functional antibodies in dried blood were highly correlated with serum (R 2 = 0.98, P <.0001). The precision of the assay for dried blood was similar to serum. The function of mAb remained stable for 9 months at room temperature and frozen dried blood samples. Conclusions We demonstrated the feasibility of measuring RSV neutralization using dried blood as a patient-centered solution that may replace serology testing in trials against RSV or other viruses, such as influenza and SARS-CoV-2. Clinical Trials Registration.  NCT05118386 (ClinicalTrials.gov). [ABSTRACT FROM AUTHOR]

Published
2024
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37. IgG1 glycosylation highlights premature aging in Down syndrome.

Author

Streng, Bianca M. M., Van Coillie, Julie, Wildenbeest, Joanne G., Binnendijk, Rob S., Smits, Gaby, den Hartog, Gerco, Wang, Wenjun, Nouta, Jan, Linty, Federica, Visser, Remco, Wuhrer, Manfred, Vidarsson, Gestur, and Bont, Louis J.

Subjects
PREMATURE aging (Medicine), LIQUID chromatography-mass spectrometry, DOWN syndrome, GLYCOSYLATION, IMMUNE response, FUCOSYLATION
Abstract

Down syndrome (DS) is characterized by lowered immune competence and premature aging. We previously showed decreased antibody response following SARS‐CoV‐2 vaccination in adults with DS. IgG1 Fc glycosylation patterns are known to affect the effector function of IgG and are associated with aging. Here, we compare total and anti‐spike (S) IgG1 glycosylation patterns following SARS‐CoV‐2 vaccination in DS and healthy controls (HC). Total and anti‐Spike IgG1 Fc N‐glycan glycoprofiles were measured in non‐exposed adults with DS and controls before and after SARS‐CoV‐2 vaccination by liquid chromatography–mass spectrometry (LC–MS) of Fc glycopeptides. We recruited N = 44 patients and N = 40 controls. We confirmed IgG glycosylation patterns associated with aging in HC and showed premature aging in DS. In DS, we found decreased galactosylation (50.2% vs. 59.0%) and sialylation (6.7% vs. 8.5%) as well as increased fucosylation (97.0% vs. 94.6%) of total IgG. Both cohorts showed similar bisecting GlcNAc of total and anti‐S IgG1 with age. In contrast, anti‐S IgG1 of DS and HC showed highly comparable glycosylation profiles 28 days post vaccination. The IgG1 glycoprofile in DS exhibits strong premature aging. The combination of an early decrease in IgG1 Fc galactosylation and sialylation and increase in fucosylation is predicted to reduce complement activity and decrease FcγRIII binding and subsequent activation, respectively. The altered glycosylation patterns, combined with decreased antibody concentrations, help us understand the susceptibility to severe infections in DS. The effect of premature aging highlights the need for individuals with DS to receive tailored vaccines and/or vaccination schedules. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis

Author

Brunwasser, Steven M, Snyder, Brittney M, Driscoll, Amanda J, Fell, Deshayne B, Savitz, David A, Feikin, Daniel R, Skidmore, Becky, Bhat, Niranjan, Bont, Louis J, Dupont, William D, Wu, Pingsheng, Gebretsadik, Tebeb, Holt, Patrick G, Zar, Heather J, Ortiz, Justin R, and Hartert, Tina V

Published
2020
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42. Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

Author

Wang, Xin, primary, Li, You, additional, Shi, Ting, additional, Bont, Louis J, additional, Chu, Helen Y, additional, Zar, Heather J, additional, Wahi-Singh, Bhanu, additional, Ma, Yiming, additional, Cong, Bingbing, additional, Sharland, Emma, additional, Riley, Richard D, additional, Deng, Jikui, additional, Figueras-Aloy, Josep, additional, Heikkinen, Terho, additional, Jones, Marcus H, additional, Liese, Johannes G, additional, Markić, Joško, additional, Mejias, Asuncion, additional, Nunes, Marta C, additional, Resch, Bernhard, additional, Satav, Ashish, additional, Yeo, Kee Thai, additional, Simões, Eric A F, additional, Nair, Harish, additional, Arruda, Eurico, additional, Baillie, Vicky L, additional, Chong, Debora, additional, Crow, Rowena, additional, Filho, Nelson Rosário, additional, Laubscher, Marius, additional, Madhi, Shabir A, additional, Mrcela, Dina, additional, Ramilo, Octavio, additional, Roje, Damir, additional, Stein, Renato Tetelbom, additional, and Yung, Chee Fu, additional

Published
2024
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44. Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trial

Author

Mazur, Natalie I., primary, Löwensteyn, Yvette N., additional, Terstappen, Jonne, additional, Leusen, Jeanette, additional, Schobben, Fred, additional, Cianci, Daniela, additional, van de Ven, Peter M., additional, Nierkens, Stefan, additional, Bont, Louis J., additional, Nibbelke, Elisabeth E., additional, Buiteman, Brigitte, additional, Rave, Neele, additional, Putten, Marlies Vermaas-van, additional, Smit-Kleinlugtenbeld, Elly A., additional, de Lege-Korstanje, Jacqueline P., additional, Peetsold, Marieke G., additional, Hulsmann, Anthon, additional, van Gool, Sandy, additional, Snepvangers, Yvonne, additional, Colombijn, Max, additional, Menelik, Negassi, additional, de Crom, Stephanie, additional, Semmekrot, Ben, additional, de Waal, Wouter J., additional, Okhuijsen, Eline, additional, ten Tusscher, Gavin W., additional, de Moor, Ronald A., additional, Breukels, Mijke A., additional, Lutterman, Claire, additional, Tramper-Stranders, Gerdien A., additional, Oudshoorn, Johanna H., additional, Ritman, Astrid, additional, von Lindern, Jeannette S., additional, Dubbink-Verheij, Gerdina H., additional, van den Berg, Maartje M., additional, Wilsterman, Marlon E.F., additional, Rietveld, Edwin, additional, van Heel, Willemijn, additional, de Grauw, Anne M., additional, Croes, Femke, additional, Doedens, Rienus A., additional, van Onzenoort-Bokken, Lonneke, additional, Meijssen, Clemens B., additional, van Scherpenzeel-de Vries, Machteld, additional, Hoekstra, Petra, additional, van Rooij, Linda G.M., additional, Boode, Willem-Pieter de, additional, van Rossem, Maaike C., additional, Sipkema, Petra, additional, Jacobs, Monique A.M., additional, van Houten, Marianne A., additional, Kok-Wijesinha, Indrani, additional, Vlieger, Arine M., additional, Balemans, Walter, additional, Plötz, Frans B., additional, Reijmerink, Naomi, additional, van Dorth, Stefan M., additional, Heikens, Willem, additional, Kuijpers, Anke G., additional, Geesing, Christel, additional, Delsing, Bas J.P., additional, Aldenhoven, Mieke, additional, Illy, Karoly, additional, Hack, Eric, additional, Groenendaal, Floris, additional, Derksen, Nicole, additional, Rengerink, Katrien Oude, additional, Meeldijk, Jan, additional, Ebskamp-van Raaij, Lysette, additional, de Groot-Mijnes, Jolanda D.F., additional, and Schuurman, Rob, additional

Published
2023
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46. Expert panel diagnosis demonstrated high reproducibility as reference standard in infectious diseases

Author

van Houten, Chantal B., Naaktgeboren, Christiana A., Ashkenazi-Hoffnung, Liat, Ashkenazi, Shai, Avis, Wim, Chistyakov, Irena, Corigliano, Teresa, Galetto, Annick, Gangoiti, Iker, Gervaix, Alain, Glikman, Daniel, Ivaskeviciene, Inga, Kuperman, Amir A., Lacroix, Laurence, Loeffen, Yvette, Luterbacher, Fanny, Meijssen, Clemens B., Mintegi, Santiago, Nasrallah, Basheer, Papan, Cihan, van Rossum, Annemarie M.C., Rudolph, Henriette, Stein, Michal, Tal, Roie, Tenenbaum, Tobias, Usonis, Vytautas, de Waal, Wouter, Weichert, Stefan, Wildenbeest, Joanne G., de Winter-de Groot, Karin M., Wolfs, Tom F.W., Mastboim, Niv, Gottlieb, Tanya M., Cohen, Asi, Oved, Kfir, Eden, Eran, Feigin, Paul D., Shani, Liran, and Bont, Louis J.

Published
2019
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49. Substantial Burden of Nonmedically Attended RSV Infection in Healthy-Term Infants: An International Prospective Birth Cohort Study.

Author

Hak, Sarah F, Venekamp, Roderick P, Billard, Marie-Noëlle, Houten, Marlies A van, Pollard, Andrew J, Heikkinen, Terho, Cunningham, Steve, Millar, Margaret, Martinón-Torres, Federico, Dacosta-Urbieta, Ana, Bont, Louis J, Wildenbeest, Joanne G, and Investigators, PROMISE

Subjects
RESPIRATORY syncytial virus infections, COHORT analysis, RESPIRATORY syncytial virus, INFANTS, CLINICAL trial registries
Abstract

Background During the first year of life, 1 in 4 infants develops a symptomatic respiratory syncytial virus (RSV) infection, yet only half seek medical attention. The current focus on medically attended RSV therefore underrepresents the true societal burden of RSV. We assessed the burden of nonmedically attended RSV infections and compared with medically attended RSV. Methods We performed active RSV surveillance until the age of 1 year in a cohort (n = 993) nested within the Respiratory Syncytial Virus Consortium in EUrope (RESCEU) prospective birth cohort study enrolling healthy term-born infants in 5 European countries. Symptoms, medication use, wheezing, and impact on family life were analyzed. Results For 97 of 120 (80.1%) nonmedically attended RSV episodes, sufficient data were available for analysis. In 50.5% (49/97), symptoms lasted ≥15 days. Parents reported impairment in usual daily activities in 59.8% (58/97) of episodes; worries, 75.3% (73/97); anxiety, 34.0% (33/97); and work absenteeism, 10.8% (10/93). Compared with medically attended RSV (n = 102, 9 hospital admissions), Respiratory Syncytial Virus NETwork (ReSViNET) severity scores were lower (3.5 vs 4.6, P <.001), whereas duration of respiratory symptoms and was comparable. Conclusions Even when medical attendance is not required, RSV infection poses a substantial burden to infants, families, and society. These findings are important for policy makers when considering the implementation of RSV immunization. Clinical Trials Registration. ClinicalTrials.gov (NCT03627572). [ABSTRACT FROM AUTHOR]

Published
2024
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