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6. Preface

Author

Bonsignore, Maria R., primary, Randerath, Winfried, additional, Schiza, Sophia E., additional, and Simonds, Anita K., additional

Published
2023
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9. Obesity and Obstructive Sleep Apnea

Author

Bonsignore, Maria R., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Eckel, Juergen, editor, and Clément, Karine, editor

Published
2022
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10. Pre-sleep arousal and sleep quality during the COVID-19 lockdown in Italy

Author

Arnaldi, Dario, Bonanni, Enrica, Bonetti, Giulio Alessandro, Castronovo, Cinzia, Maestri, Michelangelo, Garbarino, Sergio, Guarnieri, Biancamaria, Manni, Raffaele, Palagini, Laura, Puligheddu, Monica, Ferri, Raffaele, Silvani, Alessandro, Vicini, Claudio, Gorgoni, Maurizio, Scarpelli, Serena, Mangiaruga, Anastasia, Alfonsi, Valentina, Bonsignore, Maria R., Fanfulla, Francesco, Ferini-Strambi, Luigi, Nobili, Lino, Plazzi, Giuseppe, and De Gennaro, Luigi

Published
2021
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11. Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Author

Ebrahimian, Serajeddin, primary, Sillanmäki, Saara, additional, Hietakoste, Salla, additional, Kulkas, Antti, additional, Töyräs, Juha, additional, Bailón, Raquel, additional, Hernando, David, additional, Lombardi, Carolina, additional, Grote, Ludger, additional, Bonsignore, Maria R., additional, Saaresranta, Tarja, additional, Pépin, Jean-Louis, additional, Leppänen, Timo, additional, and Kainulainen, Samu, additional

Published
2024
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12. Distance follow-up by a remote medical care centre improves adherence to CPAP in patients with obstructive sleep apnoea over the short and long term

Author

Schisano, Matteo, primary, Libra, Alessandro, additional, Rizzo, Ludovica, additional, Morana, Giorgio, additional, Mancuso, Salvatore, additional, Ficili, Antonella, additional, Campagna, Davide, additional, Vancheri, Carlo, additional, Bonsignore, Maria R, additional, and Spicuzza, Lucia, additional

Published
2024
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19. REM sleep obstructive sleep apnoea

Author

Bonsignore, Maria R., primary, Mazzuca, Emilia, additional, Baiamonte, Pierpaolo, additional, Bouckaert, Bernard, additional, Verbeke, Wim, additional, and Pevernagie, Dirk A., additional

Published
2024
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27. What to expect from the ERS International Congress 2023

Author

Farr, Amy, primary, Cuevas Ocaña, Sara, additional, Gille, Thomas, additional, Pinnock, Hilary, additional, Bonsignore, Maria R., additional, Roche, Nicolas, additional, Laveneziana, Pierantonio, additional, Costello, Richard W., additional, Harari, Sergio, additional, Meiners, Silke, additional, Loukides, Stylianos, additional, and Cruz, Joana, additional

Published
2023
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28. Adaptive responses to chronic intermittent hypoxia: contributions from the European Sleep Apnoea Database (ESADA) Cohort.

Author

Bonsignore, Maria R.

Abstract

Obstructive sleep apnoea (OSA) is a common disease in the general population, and is associated with increased cardiovascular risk and several comorbidities. Obesity favours upper airway collapsibility, but other pathophysiological traits have been identified, i.e. upper airway muscle activity, modulation of the respiratory drive, and the arousal threshold. OSA causes chronic intermittent hypoxia, inflammatory activation and autonomic imbalance with diurnal and nocturnal sympathetic hyperactivity. Disentangling so many components to investigate the pathogenesis of OSA's consequences is very hard clinically. However, albeit imperfect, clinical medicine constitutes a major source of inspiration for basic research, and a mutual exchange of information is essential between clinicians and physiologists to improve our understanding of disease states. OSA is no exception, and this narrative review will summarize the results of clinical studies performed over the years by the European Sleep Apnoea Database (ESADA) Study Group, to explore the variables linked to markers of intermittent hypoxia as opposed to the traditional assessment of OSA severity based on the frequency of respiratory events during sleep (the Apnoea Hypopnoea Index). The results of the clinical studies indicate that intermittent hypoxia variables are associated with several comorbidities, although evidence of a cause–effect relationship is still missing in many cases. It is also possible that adaptive rather than maladaptive responses could be evoked by intermittent hypoxia. The intensity, duration and frequency of intermittent hypoxia episodes causing adaptive rather than maladaptive responses, and their clinical implications, deserve further investigation. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Sleep and cardiometabolic comorbidities in the OSA-COPD overlap syndrome: Data from ESADA

Author

van Zeller, Mafalda, primary, Basoglu, Ozen K., additional, Verbraecken, Johan, additional, Lombardi, Carolina, additional, McNicholas, Walter T., additional, Pepin, Jean-Louis, additional, Steiropoulos, Paschalis, additional, Sliwinski, Pawel, additional, Correia, Daniela, additional, Bonsignore, Maria R., additional, Schiza, Sophia E., additional, Hedner, Jan, additional, Grote, Ludger, additional, and Drummond, Marta, additional

Published
2023
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36. Brain and Breathing

Author

Bonsignore, Maria R., Marrone, Oreste, Garbarino, Sergio, editor, Nobili, Lino, editor, and Costa, Giovanni, editor

Published
2014
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39. Clinical characteristics and PAP adherence among elderly European sleep apnoea patients from the ESADA cohort

Author

Lammintausta, Aino, primary, Anttalainen, Ulla, additional, Basoglu, Özen K., additional, Bonsignore, Maria R., additional, Gouveris, Haralampos, additional, Grote, Ludger, additional, Hedner, Jan, additional, Ludka, Ondrej, additional, Mihaicuta, Stefan, additional, Pataka, Athanasia, additional, Trakada, Georgia, additional, van Zeller, Mafalda, additional, and Saaresranta, Tarja, additional

Published
2023
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42. Application of Inverse-Probability-of-Treatment Weighting to Estimate the Effect of Daytime Sleepiness in Obstructive sleep apnea patients

Author

Bettega, François, Leyrat, Clémence, Tamisier, Renaud, Mendelson, Monique, Grillet, Yves, Sapene, Marc, Bonsignore, Maria R, Pepin, Jean Louis, Kattan, Michael W, Bailly, Sébastien, Bettega, Françoi, Leyrat, Clémence, Tamisier, Renaud, Mendelson, Monique, Grillet, Yve, Sapene, Marc, Bonsignore, Maria R, Pepin, Jean Loui, Kattan, Michael W, and Bailly, Sébastien

Subjects
Settore MED/10 - Malattie Dell'Apparato Respiratorio, inverse probability weight, daytime sleepiness, sleep apnea, Causal inference
Abstract

Continuous positive airway pressure (CPAP), the first line therapy for obstructive sleep apnea (OSA), is considered effective in reducing daytime sleepiness. Its efficacy relies on adequate adherence, often defined as >4 hours per night. However, this binary threshold may limit our understanding of the causal effect of CPAP adherence and daytime sleepiness and multilevel approach for CPAP adherence can be more appropriate.

Published
2022

43. Application of Inverse-Probability-of-Treatment Weighting to Estimate the Effect of Daytime Sleepiness in Patients with Obstructive Sleep Apnea

Author

Bettega, François, primary, Leyrat, Clémence, additional, Tamisier, Renaud, additional, Mendelson, Monique, additional, Grillet, Yves, additional, Sapène, Marc, additional, Bonsignore, Maria R., additional, Pépin, Jean Louis, additional, Kattan, Michael W., additional, and Bailly, Sébastien, additional

Published
2022
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46. Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view

Author

Craig, Sonya, Pepin, Jean-Louis, Randerath, Winfried, Causse, Christian, Verbraecken, Johan, Asin, Jerryll, Barbe, Ferran, Bonsignore, Maria R., Craig, Sonya, Pepin, Jean-Louis, Randerath, Winfried, Causse, Christian, Verbraecken, Johan, Asin, Jerryll, Barbe, Ferran, and Bonsignore, Maria R.

Abstract

Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA), defined as the inability to stay awake during the day. Its clinical descriptors remain elusive, and the pathogenesis is complex, with disorders such as insufficient sleep and depression commonly associated. Subjective EDS can be evaluated using the Epworth Sleepiness Scale, in which the patient reports the probability of dozing in certain situations; however, its reliability has been challenged. Objective tests such as the multiple sleep latency test or the maintenance of wakefulness test are not commonly used in patients with OSA, since they require nocturnal polysomnography, daytime testing and are expensive. Drugs for EDS are available in the United States but were discontinued in Europe some time ago. For European respiratory physicians, treatment of EDS with medication is new and they may lack experience in pharmacological treatment of EDS, while novel wake-promoting drugs have been recently developed and approved for clinical use in OSA patients in the USA and Europe. This review will discuss 1) the potential prognostic significance of EDS in OSA patients at diagnosis, 2) the prevalence and predictors of residual EDS in treated OSA patients, and 3) the evolution of therapy for EDS specifically for Europe.

Published
2022

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