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1. Clinical Outcome and 7-Day Virological Clearance in High-Risk Patients with Mild–Moderate COVID-19 Treated with Molnupiravir, Nirmatrelvir/Ritonavir, or Remdesivir

Author

Bai, Francesca, Beringheli, Tomaso, Vitaletti, Virginia, Santoro, Andrea, Molà, Francesco, Copes, Alessandro, Gemignani, Nicole, Pettenuzzo, Sofia, Castoldi, Roberto, Varisco, Benedetta, Nardo, Riccardo, Lundgren, Lorenzo Brando, Ligresti, Riccardo, Sala, Matteo, Albertini, Lorenzo, Augello, Matteo, Biasioli, Lorenzo, Bono, Valeria, Rovito, Roberta, Bini, Teresa, Passarella, Sabrina, Orfeo, Nicola Vincenzo, Monforte, Antonella d’Arminio, and Marchetti, Giulia

Published
2024
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3. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori., Andrea, Bandera, Alessandra, Muscatello, Antonio, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi., Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Renisi, Giulia, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Viero, Giulia, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Peyvandi, Flora, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero., Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili., Alessandro, Tettamanti, Mauro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Azzarà, Cecilia, Mantero, Marco, Bassetti, Matteo, Marchetti, Giulia, Nobili, Alessandro, and Gori, Andrea

Published
2024
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10. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Lombardi, Andrea, primary, Villa, Simone, additional, Colaneri, Marta, additional, Scaglione, Giovanni, additional, Bai, Francesca, additional, Varisco, Benedetta, additional, Bono, Valeria, additional, Vena, Antonio, additional, Dentone, Chiara, additional, Russo, Chiara, additional, Tettamanti, Mauro, additional, Renisi, Giulia, additional, Viero, Giulia, additional, Azzarà, Cecilia, additional, Mantero, Marco, additional, Peyvandi, Flora, additional, Bassetti, Matteo, additional, Marchetti, Giulia, additional, Muscatello, Antonio, additional, Nobili, Alessandro, additional, Gori, Andrea, additional, Bandera, Alessandra, additional, Bosari, Silvano, additional, Scudeller, Luigia, additional, Fusetti, Giuliana, additional, Rusconi, Laura, additional, Dell’Orto, Silvia, additional, Prati, Daniele, additional, Valenti, Luca, additional, Giovannelli, Silvia, additional, Manunta, Maria, additional, Lamorte, Giuseppe, additional, Ferarri, Francesca, additional, Gori., Andrea, additional, Mangioni, Davide, additional, Alagna, Laura, additional, Bozzi, Giorgio, additional, Lombardi., Andrea, additional, Ungaro, Riccardo, additional, Ancona, Giuseppe, additional, Mussa, Marco, additional, Mariani, Bianca Veronica, additional, Bolis, Matteo, additional, Iannotti, Nathalie, additional, Ludovisi, Serena, additional, Comelli, Agnese, additional, Biscarini, Simona, additional, Castelli, Valeria, additional, Palomba, Emanuele, additional, Fava, Marco, additional, Peri, Carlo Alberto, additional, Saltini, Paola, additional, Itri, Teresa, additional, Ferroni, Valentina, additional, Pastore, Valeria, additional, Massafra, Roberta, additional, Liparoti, Arianna, additional, Muheberimana, Toussaint, additional, Giommi, Alessandro, additional, Bianco, Rosaria, additional, Chitani, Grazia Eliana, additional, Bobbio, Chiara, additional, De Matteis, Irene, additional, Bonomi, Angelo Bianchi, additional, Gualtierotti, Roberta, additional, Ferrari, Barbara, additional, Rossio, Raffaella, additional, Boasi, Nadia, additional, Pagliaro, Erica, additional, Massimo, Costanza, additional, De Caro, Michele, additional, Giachi, Andrea, additional, Montano, Nicola, additional, Vigone, Barbara, additional, Bellocchi, Chiara, additional, Carandina, Angelica, additional, Fiorelli, Elisa, additional, Melli, Valerie, additional, Tobaldini, Eleonora, additional, Blasi, Francesco, additional, Aliberti, Stefano, additional, Spotti, Maura, additional, Terranova, Leonardo, additional, Misuraca, Sofia, additional, D’Adda, Alice, additional, Della Fiore, Silvia, additional, Di Pasquale, Marta, additional, Mantero., Marco, additional, Contarini, Martina, additional, Ori, Margherita, additional, Morlacchi, Letizia, additional, Rossetti, Valeria, additional, Gramegna, Andrea, additional, Pappalettera, Maria, additional, Cavallini, Mirta, additional, Buscemi, Agata, additional, Vicenzi, Marco, additional, Rota, Irena, additional, Costantino, Giorgio, additional, Solbiati, Monica, additional, Furlan, Ludovico, additional, Mancarella, Marta, additional, Colombo, Giulia, additional, Colombo, Giorgio, additional, Fanin, Alice, additional, Passarella, Mariele, additional, Monzani, Valter, additional, Canetta, Ciro, additional, Rovellini, Angelo, additional, Barbetta, Laura, additional, Billi, Filippo, additional, Folli, Christian, additional, Accordino, Silvia, additional, Maira, Diletta, additional, Hu, Cinzia Maria, additional, Motta, Irene, additional, Scaramellini, Natalia, additional, Fracanzani, Anna Ludovica, additional, Lombardi, Rosa, additional, Cespiati, Annalisa, additional, Cesari, Matteo, additional, Lucchi, Tiziano, additional, Proietti, Marco, additional, Calcaterra, Laura, additional, Mandelli, Clara, additional, Coppola, Carlotta, additional, Cerizza, Arturo, additional, Pesenti, Antonio Maria, additional, Grasselli, Giacomo, additional, Galazzi, Alessandro, additional, Nobili., Alessandro, additional, Monti, Igor, additional, Galbussera, Alessia Antonella, additional, Crisafulli, Ernesto, additional, Girelli, Domenico, additional, Maroccia, Alessio, additional, Gabbiani, Daniele, additional, Busti, Fabiana, additional, Vianello, Alice, additional, Biondan, Marta, additional, Sartori, Filippo, additional, Faverio, Paola, additional, Pesci, Alberto, additional, Zucchetti, Stefano, additional, Bonfanti, Paolo, additional, Rossi, Marianna, additional, Beretta, Ilaria, additional, Spolti, Anna, additional, Harari, Sergio, additional, Elia, Davide, additional, Cassandro, Roberto, additional, Caminati, Antonella, additional, Cipollone, Francesco, additional, Guagnano, Maria Teresa, additional, D’Ardes, Damiano, additional, Rossi, Ilaria, additional, Vezzani, Francesca, additional, Spanevello, Antonio, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Contoli, Marco, additional, Papi, Alberto, additional, Morandi, Luca, additional, Battistini, Nicholas, additional, Moreo, Guido Luigi, additional, Iannuzzi, Pasqualina, additional, Fumagalla, Daniele, additional, and Leone, Sara, additional

Published
2024
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11. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Author

Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, A, Villa, S, Colaneri, M, Scaglione, G, Bai, F, Varisco, B, Bono, V, Vena, A, Dentone, C, Russo, C, Tettamanti, M, Renisi, G, Viero, G, Azzarà, C, Mantero, M, Peyvandi, F, Bassetti, M, Marchetti, G, Muscatello, A, Nobili, A, Gori, A, Bandera, A, Bosari, S, Scudeller, L, Fusetti, G, Rusconi, L, Dell’Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferarri, F, Gori., A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi., A, Ungaro, R, Ancona, G, Mussa, M, Mariani, B, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Peri, C, Saltini, P, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, Chitani, G, Bobbio, C, De Matteis, I, Bonomi, A, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Giachi, A, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D’Adda, A, Della Fiore, S, Di Pasquale, M, Mantero., M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Nobili., A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Harari, S, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D’Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalla, D, Leone, S, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Tettamanti, Mauro, Renisi, Giulia, Viero, Giulia, Azzarà, Cecilia, Mantero, Marco, Peyvandi, Flora, Bassetti, Matteo, Marchetti, Giulia, Muscatello, Antonio, Nobili, Alessandro, Gori, Andrea, Bandera, Alessandra, Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori. , Andrea, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi. , Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero. , Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili. , Alessandro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, and Leone, Sara

Abstract

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson's Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised wit

Published
2024

14. Primary HIV infection features colonic damage and neutrophil inflammation yet containment of microbial translocation

Author

Tincati, Camilla, primary, Bono, Valeria, additional, Cannizzo, Elvira Stefania, additional, Tosi, Delfina, additional, Savi, Federica, additional, Falcinella, Camilla, additional, Casabianca, Anna, additional, Orlandi, Chiara, additional, Luigiano, Carmelo, additional, Augello, Matteo, additional, Rusconi, Stefano, additional, Muscatello, Antonio, additional, Bandera, Alessandra, additional, Calcagno, Andrea, additional, Gori, Andrea, additional, Nozza, Silvia, additional, and Marchetti, Giulia, additional

Published
2023
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16. Impairment of platelet function in both mild and severe COVID‐19 patients.

Author

Scavone, Mariangela, Ghali, Claudia, Calogiuri, Mariagrazia, Sala, Matteo, Bossi, Elena, Mencarini, Tatiana, Bozzi, Silvia, Clerici, Bianca, Birocchi, Simone, Fioretti, Antonella, Bono, Valeria, Maugeri, Norma, Marchetti, Giulia, Cattaneo, Marco, and Podda, Gian Marco

Subjects
COVID-19, BLOOD platelets, BLOOD platelet activation, LIGHT transmission, BLOOD platelet aggregation, BLOOD platelet disorders, SEROTONIN syndrome
Abstract

Summary: Abnormalities of platelet function were reported in patients with severe COVID‐19 (severe‐C), but few data are available in patients with mild COVID‐19 (mild‐C) and after COVID‐19 recovery. The aim of this study was to investigate platelet parameters in mild‐C patients (n = 51), with no evidence of pneumonia, and severe‐C patients (n = 49), during the acute phase and after recovery, compared to 43 healthy controls. Both mild‐C and severe‐C patients displayed increased circulating activated platelets, low δ‐granule content (ADP, serotonin), impaired platelet activation by collagen (light transmission aggregometry) and impaired platelet thrombus formation on collagen‐coated surfaces under controlled flow conditions (300/s shear rate). The observed abnormalities were more marked in severe‐C patients than in mild‐C patients. Overall, 61% (30/49) of mild‐C and 73% (33/45) of severe‐C patients displayed at least one abnormal platelet parameter. In a subgroup of just 13 patients who showed no persisting signs/symptoms of COVID‐19 and were re‐evaluated at least 1 month after recovery, 11 of the 13 subjects exhibited normalization of platelet parameters. In conclusion, mild abnormalities of platelet parameters were present not only in severe‐C but also, albeit to a lesser extent, in mild‐C patients during the acute phase of COVID‐19 and normalized in most tested patients after clinical recovery. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Growth Differentiation Factor 15 (GDF-15) Levels Associate with Lower Survival in Chronic Kidney Disease Patients with COVID-19

Author

Galassi, Andrea, primary, Ciceri, Paola, additional, Bono, Valeria, additional, Magagnoli, Lorenza, additional, Sala, Matteo, additional, Artioli, Luisa, additional, Rovito, Roberta, additional, Hadla, Mohamad, additional, Yellenki, Vaibhav, additional, D’Arminio Monforte, Antonella, additional, Tincati, Camilla, additional, Cozzolino, Mario, additional, and Marchetti, Giulia, additional

Published
2022
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20. Inflammation and intracellular exposure of dolutegravir, darunavir, tenofovir and emtricitabine in people living with HIV

Author

Ferrara, Micol, primary, Cusato, Jessica, additional, Salvador, Elena, additional, Trentalange, Alice, additional, Alcantarini, Chiara, additional, Trunfio, Mattia, additional, Cannizzo, Elvira Stefania, additional, Bono, Valeria, additional, Nozza, Silvia, additional, De Nicolò, Amedeo, additional, Ianniello, Alice, additional, De Vivo, Elisa, additional, D'Avolio, Antonio, additional, Di Perri, Giovanni, additional, Bonora, Stefano, additional, Marchetti, Giulia, additional, and Calcagno, Andrea, additional

Published
2022
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24. Inflammation and intracellular exposure of dolutegravir, darunavir, tenofovir and emtricitabine in people living with HIV.

Author

Ferrara, Micol, Cusato, Jessica, Salvador, Elena, Trentalange, Alice, Alcantarini, Chiara, Trunfio, Mattia, Cannizzo, Elvira Stefania, Bono, Valeria, Nozza, Silvia, De Nicolò, Amedeo, Ianniello, Alice, De Vivo, Elisa, D'Avolio, Antonio, Di Perri, Giovanni, Bonora, Stefano, Marchetti, Giulia, and Calcagno, Andrea

Subjects
HIV, EMTRICITABINE-tenofovir, HIV-positive persons, RITONAVIR, ATAZANAVIR, DARUNAVIR, DOLUTEGRAVIR, ANTI-HIV agents
Abstract

Aims: Antiretroviral (ARV) therapy reduces inflammation and immune activation in people with HIV, but not down to the levels observed in people without HIV. Limited drug penetration within tissues has been argued as a potential mechanism of persistent inflammation. Data on the inflammation role on ARV plasma/intracellular (IC) pharmacokinetics (PK) through to expression of cytochrome P450 3A/membrane transporters are limited. The aim of this study was to investigate the correlation between inflammation markers (IM) and plasma/IC PK of ARV regimen in HIV‐positive patients. Methods: We included ART‐experienced patients switching to three different ARV regimens. Plasma and IC ARV drug concentration means at the end of dosing interval (T0), IM on samples concomitantly with ARV PK determination: sCD14, CRP, IL‐6 and LPS were analysed. Results: Plasma and IC drug concentrations were measured in 60 samples. No significative differences between CRP, sCD14, IL‐6 and LPS values in the three arms were observed. A significant inverse correlation between tenofovir plasma concentration and sCD14 (rho = −0.79, P <.001), and between DRV IC/plasma ratio and Log10 IL‐6 concentrations (rho = −0.36, P =.040), and a borderline statistically significant positive trend between DRV plasma concentration and sCD14 (rho = 0.31, P =.070) were suggested. Furthermore, a borderline statistically significant inverse trend between DTG IC concentrations and sCD14 (rho = −0.34, P =.090) was observed in 24 patients on DTG‐based triple therapy. Conclusions: Our preliminary data support the hypothesis of lower DRV and DTG IC concentrations and lower TFV plasma exposure in patients with higher plasma IM suggesting an interplay between HIV drug penetration and persistent inflammation in cART‐treated HIV‐positive patients. [ABSTRACT FROM AUTHOR]

Published
2023
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25. MO409: GDF-15 is a Predictor of Mortality in Chronic Kidney Disease Patients With Covid-19 Infection

Author

Ciceri, Paola, primary, Bono, Valeria, additional, Magagnoli, Lorenza, additional, Sala, Matteo, additional, Artioli, Luisa, additional, Rovito, Roberta, additional, Adla, Mohamad, additional, Yellenki, Vaibhav, additional, D'arminio Monforte, Antonella, additional, Galassi, Andrea, additional, Tincati, Camilla, additional, Marchetti, Giulia, additional, and Gennaro Cozzolino, Mario, additional

Published
2022
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26. Persistence of High Percentage of Peripheral Activated CD8+ T Cells Predict Cytologic HPV-Related Dysplasia in cART-Treated, HIV-Positive Subjects

Author

Mondatore, Debora, primary, Bai, Francesca, additional, Augello, Matteo, additional, Giovenzana, Marco, additional, Pisani Ceretti, Andrea, additional, Bono, Valeria, additional, Opocher, Enrico, additional, d’Arminio Monforte, Antonella, additional, Marchetti, Giulia Carla, additional, and Tincati, Camilla, additional

Published
2022
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27. Renal microsporidiosis due to Encephalitozoon cuniculi in an HIV/AIDS patient with persistent fever and kidney injury

Author

Augello, Matteo, primary, Bai, Francesca, additional, Galassi, Andrea, additional, Bono, Valeria, additional, Moro, Alessia, additional, Carsana, Luca, additional, Tonello, Cristina, additional, Tosoni, Antonella, additional, Nebuloni, Manuela, additional, Monforte, Antonella d’Arminio, additional, and Marchetti, Giulia, additional

Published
2021
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29. Long-Term Suppressive cART Is Not Sufficient to Restore Intestinal Permeability and Gut Microbiota Compositional Changes

Author

Ancona, Giuseppe, primary, Merlini, Esther, additional, Tincati, Camilla, additional, Barassi, Alessandra, additional, Calcagno, Andrea, additional, Augello, Matteo, additional, Bono, Valeria, additional, Bai, Francesca, additional, Cannizzo, Elvira S., additional, d'Arminio Monforte, Antonella, additional, and Marchetti, Giulia, additional

Published
2021
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31. Aspirin in a diabetic retinopathy setting: Insights from NO BLIND study

Author

Pafundi, Pia Clara, primary, Galiero, Raffaele, additional, Caturano, Alfredo, additional, Acierno, Carlo, additional, de Sio, Chiara, additional, Vetrano, Erica, additional, Nevola, Riccardo, additional, Gelso, Aldo, additional, Bono, Valeria, additional, Costagliola, Ciro, additional, Marfella, Raffaele, additional, Sardu, Celestino, additional, Rinaldi, Luca, additional, Salvatore, Teresa, additional, Adinolfi, Luigi Elio, additional, and Sasso, Ferdinando Carlo, additional

Published
2020
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32. Telemedicine for screening diabetic retinopathy: The NO BLIND Italian multicenter study

Author

Sasso, Ferdinando Carlo, Pafundi, Pia Clara, Gelso, Aldo, Bono, Valeria, Costagliola, Ciro, Marfella, Raffaele, Sardu, Celestino, Rinaldi, Luca, Galiero, Raffaele, Acierno, Carlo, de Sio, Chiara, Adinolfi, Luigi Elio, Sasso, F. C., Pafundi, P. C., Gelso, A., Bono, V., Costagliola, C., Marfella, R., Sardu, C., Rinaldi, L., Galiero, R., Acierno, C., de Sio, C., Adinolfi, L. E., Sasso, Ferdinando Carlo, Pafundi, Pia Clara, Gelso, Aldo, Bono, Valeria, Costagliola, Ciro, Marfella, Raffaele, Sardu, Celestino, Rinaldi, Luca, Galiero, Raffaele, Acierno, Carlo, de Sio, Chiara, and Adinolfi, Luigi Elio

Subjects
Male, Diabetic Retinopathy, Fundus Oculi, screening, cost-effectivene, Pilot Projects, Middle Aged, Prognosis, Telemedicine, Diabetes Mellitus, Type 2, Italy, cost-effectiveness, diabetic retinopathy, observational study, Prevalence, Humans, Mass Screening, Female, Aged, Follow-Up Studies
Abstract

Aims: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening programme many patients who otherwise would be excluded. Materials and methods: The NO BLIND is a transversal, multicentre, observational study. Its pilot phase involved nine public outpatient clinics for 6 months. As endpoint of the study, we assessed the prevalence of DR by retinography in a subset of the Italian population. Patients' fundus oculi photos were performed by trained diabetologists through a digital smart ophthalmoscope. Results: According to our endpoint, in the final study population (n = 1461), obtained excluding patients for whom retinography was not able to provide any diagnosis, DR prevalence was equal to 15.5%. According to the receiver operating characteristic (ROC) curve performed, we can observe how retinography appears a highly accurate method to detect DR (AUROC 0.971, 95% confidence interval, 0.954-0.989), with a specificity of the 100% and a sensitivity of the 94.3%. Conclusions: Our findings, in an Italian setting, confirm main data in the literature about DR prevalence. Hence, telemedicine could represent an accurate, fast, and cheap method for screening of DR. © 2018 John Wiley & Sons, Ltd. Aims. Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening program many patients who otherwise would be excluded. Materials and Methods. The NO Blind is a transversal, multicentre, observational study. Its pilot phase involved nine public outpatient clinics for six months. As endpoint of the study, we assessed the prevalence of DR by retinography in a subset of the Italian population. Patients’ fundus oculi photos were performed by trained diabetologists through a digital smart ophthalmoscope. Results. According to our endpoint, in the final study population (n=1461), obtained excluding patients for whom retinography was not able to provide any diagnosis, DR This article is protected by copyright. All rights reserved. prevalence was equal to 15.5%. According to the ROC Curve performed, we can observe how retinography appears a highly accurate method to detect DR (AUROC 0.971 95% C.I. 0.954-0.989), with a specificity of the 100% and a sensitivity of the 94.3%. Conclusions. Our findings, in an Italian setting, confirm main data in the literature about DR prevalence. Hence, telemedicine could represent an accurate, fast and cheap method for screening of DR.

Published
2018

35. ADAPTIVE IMMUNITY DYSREGULATION IS ASSOCIATED TO THE DEVELOPMENT OF LONG COVID.

Author

Rovito, Roberta, Bono, Valeria, Augello, Matteo, Bai, Francesca, Tincati, Camilla, Beaudoin-Bussières, Guillaume, Tauzin, Alexandra, Bianchi, Silvia, Mikulak, Joanna, Borghi, Elisa, Monforte, Antonella D'Arminio, Bella, Silvia Della, Finzi, Andrés, Mavilio, Domenico, and Marchetti, Giulia C.

Published
2023

36. dilatazione pupillare farmacologica come test predittivo del rischio di IFIS

Author

BONO, Valeria, CILLINO, Giovanni, SPITALE, Emanuela Rosaria, CASUCCIO, Alessandra, CILLINO, Salvatore, Bono, V, Cillino, G, Spitale, ER, Casuccio, A, and Cillino, S

Subjects
Settore MED/30 - Malattie Apparato Visivo, floppy iris syndrome, predittività rischio IFIS, dilatazione pupillare
Published
2013

42. Telemedicine for screening diabetic retinopathy: The NO BLIND Italian multicenter study.

Author

Sasso, Ferdinando Carlo, Pafundi, Pia Clara, Gelso, Aldo, Bono, Valeria, Costagliola, Ciro, Marfella, Raffaele, Sardu, Celestino, Rinaldi, Luca, Galiero, Raffaele, Acierno, Carlo, Sio, Chiara, Adinolfi, Luigi Elio, de Sio, Chiara, and NO BLIND Study Group

Abstract

Aims: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening programme many patients who otherwise would be excluded.Materials and Methods: The NO BLIND is a transversal, multicentre, observational study. Its pilot phase involved nine public outpatient clinics for 6 months. As endpoint of the study, we assessed the prevalence of DR by retinography in a subset of the Italian population. Patients' fundus oculi photos were performed by trained diabetologists through a digital smart ophthalmoscope.Results: According to our endpoint, in the final study population (n = 1461), obtained excluding patients for whom retinography was not able to provide any diagnosis, DR prevalence was equal to 15.5%. According to the receiver operating characteristic (ROC) curve performed, we can observe how retinography appears a highly accurate method to detect DR (AUROC 0.971, 95% confidence interval, 0.954-0.989), with a specificity of the 100% and a sensitivity of the 94.3%.Conclusions: Our findings, in an Italian setting, confirm main data in the literature about DR prevalence. Hence, telemedicine could represent an accurate, fast, and cheap method for screening of DR. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Aspirin in a diabetic retinopathy setting: Insights from NO BLIND study

Author

Teresa Salvatore, Erica Vetrano, Raffaele Galiero, Ciro Costagliola, Aldo Gelso, Carlo Acierno, Pia Clara Pafundi, Alfredo Caturano, Raffaele Marfella, Ferdinando Carlo Sasso, Riccardo Nevola, Luigi Elio Adinolfi, Celestino Sardu, Luca Rinaldi, Valeria Bono, Chiara de Sio, Clara Pafundia, Pia, Galieroa, Raffaele, Caturano, Alfredo, Aciernoa, Carlo, de Sio, Chiara, Vetrano, Erica, Nevolaa, Riccardo, Gelso, Aldo, Bono, Valeria, Costagliola, Ciro, Marfella, Raffaele, Sardu, Celestino, Rinaldi, Luca, Salvatore, Teresa, Adinolfi, Luigi Elio, Sasso, Ferdinando Carlo, Pafundi, P. C., Galiero, R., Caturano, A., Acierno, C., de Sio, C., Vetrano, E., Nevola, R., Gelso, A., Bono, V., Costagliola, C., Marfella, R., Sardu, C., Rinaldi, L., Salvatore, T., Adinolfi, L. E., and Sasso, F. C.

Subjects
Male, medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Risk Assessment, Diabetes complication, 03 medical and health sciences, 0302 clinical medicine, Diabetes complications, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Clinical endpoint, Humans, Outpatient clinic, diabetic retinopathyaspirintype 2 diabetesdiabetes complications, Aged, Aspirin, Diabetic Retinopathy, Nutrition and Dietetics, business.industry, Diabetic retinopathy, Cardiovascular Agents, Middle Aged, medicine.disease, Cross-Sectional Studies, Treatment Outcome, Diabetes Mellitus, Type 2, Italy, Cardiovascular Diseases, Cohort, Female, Observational study, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Background and aims Diabetic retinopathy (DR) is the most common microvascular complication of diabetes. Diabetic macroangiopathies, particularly cardiovascular (CV) diseases, seem closely related to diabetes microvascular complications. Aspirin represents the most prescribed compound in CV prevention. Aspirin impact on DR is still object of debate. As it is already recommended among diabetics at high CV risk, aim of this study was to assess a potential relationship between DR and aspirin therapy, in a type 2 diabetes cohort of patients screened through telemedicine. Methods and results NO Blind is a cross-sectional, multicenter, observational study, which involved nine Italian outpatient clinics. Primary endpoint was the assessment of the relationship between aspirin treatment and DR. 2068 patients were enrolled in the study, subsequently split in two subpopulations according to either the presence or absence of DR. Overall, 995 subjects were under aspirin therapy. After adjusting for most common potential confounders, age and gender, aspirin reveals significantly associated with DR (OR: 1.72, 95%CI: 1.58–2.89, p = 0.002) and proliferative DR (PDR) (OR: 1.89, 95%CI: 1.24–2.84, p = 0.003). Association comes lost further adjusting for MACEs (OR: 1.28, 95%CI: 0.85–1.42, p = 0.157) (Model 4) and eGFR (OR: 0.93; 95%CI: 0.71–1.22; p = 0.591) (Model 5). Conclusion In this multicenter cross-sectional study including a large sample of outpatients with T2DM, we showed that aspirin was not associated with DR after adjustment for several cardio-metabolic confounders. However, as partially confirmed by our findings, and related to the well-known pro-hemorrhagic effect of aspirin, its use should be individually tailored, even by telemedicine tools.

Published
2020

44. High HDL cholesterol: A risk factor for diabetic retinopathy? Findings from NO BLIND study

Author

Valeria Bono, Ferdinando Carlo Sasso, Raffaele Galiero, Pia Clara Pafundi, Luigi Elio Adinolfi, Celestino Sardu, Raffaele Marfella, Luca Rinaldi, Carlo Acierno, Chiara de Sio, Ciro Costagliola, Teresa Salvatore, Aldo Gelso, Alfredo Caturano, Sasso, Ferdinando Carlo, Pafundi, Pia Clara, Gelso, Aldo, Bono, Valeria, Costagliola, Ciro, Marfella, Raffaele, Sardu, Celestino, Rinaldi, Luca, Galiero, Raffaele, Acierno, Carlo, de Sio, Chiara, Caturano, Alfredo, Salvatore, Teresa, and Adinolfi, Luigi Elio

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Type 2 diabetes, Diabetes complication, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Blind study, Endocrinology, Diabetes complications, HDL cholesterol, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Internal Medicine, Outpatient clinic, Humans, 030212 general & internal medicine, education, Diabetic retinopathy, Risk factors, Aged, education.field_of_study, Diabetic Retinopathy, Cholesterol, business.industry, Incidence, Cholesterol, HDL, General Medicine, Middle Aged, medicine.disease, Diabetes and Metabolism, Cross-Sectional Studies, chemistry, Diabetes Mellitus, Type 2, Italy, ROC Curve, Observational study, Female, Risk factor, business
Abstract

Aims: To assess the correlation between diabetic retinopathy (DR) and potential risk factors, as well as the relationship between DR and the other complications of diabetes, in a real-life population of type 2 diabetes patients recruited in several centres in Italy. Methods: The NO BLIND is a cross-sectional, multicentre, observational study, which involved nine public outpatient clinics in Italy. The patients were assessed for eligibility from November 2016 till November 2017. Those enrolled underwent standard fundus oculi exam. Clinical and laboratory data were also collected. Results: 2068 T2DM underwent fundus oculi exam. 435 received diagnosis of diabetic retinopathy (21%). Diabetic retinopathy was independently associated with HDL cholesterol (O.R.: 1.042; 95% C.I.: 1.012–1.109; p = 0.004), Albumin Excretion Rate (AER) (O.R.: 1.001; 95% C.I.: 1.000–1.002; p = 0.034) and GFR (O.R.: 1.159; 95% C.I.: 1.039–1.294; p = 0.008). HDL cholesterol values were hence split in two classes according to a potential cut-off (40 mg/dL), as defined by the ROC curve. Following analysis confirmed the association between DR and high HDL values (p = 0.032). Somatic neuropathy and diabetic ulcer were independently related with DR (p < 0.001 and p = 0.012, respectively). Conclusions: A novel relationship between high HDL cholesterol and DR was observed. © 2019 Elsevier B.V. Aims: To assess the correlation between diabetic retinopathy (DR) and potential risk factors, as well as the relationship between DR and the other complications of diabetes, in a real-life population of type 2 diabetes patients recruited in several centres in Italy. Methods: The NO BLIND is a cross-sectional, multicentre, observational study, which involved nine public outpatient clinics in Italy. The patients were assessed for eligibility from November 2016 till November 2017. Those enrolled underwent standard fundus oculi exam. Clinical and laboratory data were also collected. Results: 2068 T2DM underwent fundus oculi exam. 435 received diagnosis of diabetic retinopathy (21%). Diabetic retinopathy was independently associated with HDL cholesterol (O.R.: 1.042; 95% C.I.: 1.012–1.109; p = 0.004), Albumin Excretion Rate (AER) (O.R.: 1.001; 95% C.I.: 1.000–1.002; p = 0.034) and GFR (O.R.: 1.159; 95% C.I.: 1.039–1.294; p = 0.008). HDL cholesterol values were hence split in two classes according to a potential cut-off (40 mg/dL), as defined by the ROC curve. Following analysis confirmed the association between DR and high HDL values (p = 0.032). Somatic neuropathy and diabetic ulcer were independently related with DR (p < 0.001 and p = 0.012, respectively). Conclusions: A novel relationship between high HDL cholesterol and DR was observed.

Published
2019

45. Markers of T-cell dysfunction and not inflammaging predict the waning of humoral responses to SARS-CoV-2 mRNA booster vaccination in people with HIV.

Author

Augello M, Bono V, Rovito R, Santoro A, Tincati C, and Marchetti G

Subjects
Humans, Male, Female, Prospective Studies, Middle Aged, Longitudinal Studies, Adult, Immunity, Humoral, SARS-CoV-2 immunology, Biomarkers blood, T-Lymphocytes immunology, CD4-CD8 Ratio, HIV Infections immunology, COVID-19 immunology, COVID-19 prevention & control, COVID-19 Vaccines immunology, COVID-19 Vaccines administration & dosage, Antibodies, Viral blood, Immunization, Secondary
Abstract

In this prospective longitudinal study, we evaluated the durability of humoral responses to SARS-CoV-2 mRNA booster vaccination in 93 people with HIV, exploring the possible role of T-cell dysfunction and inflammaging biomarkers in predicting antibody waning. We found that, despite a negligible influence of the inflammaging milieu, low CD4/CD8 ratio and CD4+CD127+ percentage as well as high CD8+CD38+CD45RO+ percentage are associated with faster antibody waning, in turn contributing to our understanding of the determinants of COVID-19 vaccine-elicited immune response in this population., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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46. Association between SARS-CoV-2 RNAemia, skewed T cell responses, inflammation, and severity in hospitalized COVID-19 people living with HIV.

Author

Augello M, Bono V, Rovito R, Tincati C, Bianchi S, Taramasso L, Di Biagio A, Callegaro A, Maggiolo F, Borghi E, Monforte AD, and Marchetti G

Abstract

Severe COVID-19 outcomes have been reported in people living with HIV (PLWH), yet the underlying pathogenetic factors are largely unknown. We therefore aimed to assess SARS-CoV-2 RNAemia and plasma cytokines in PLWH hospitalized for COVID-19 pneumonia, exploring associations with magnitude and functionality of SARS-CoV-2-specific immune responses. Eighteen unvaccinated PLWH (16/18 on cART; median CD4 T cell count 361.5/μL; HIV-RNA<50 cp/mL in 15/18) and 18 age/sex-matched people without HIV were consecutively recruited at a median time of 10 days from symptoms onset. PLWH showed greater SARS-CoV-2 RNAemia, a distinct plasma cytokine profile, and worse respiratory function (lower P a O 2 /F i O 2 nadir ), all correlating with skewed T cell responses (higher perforin production by cytotoxic T cells as well as fewer and less polyfunctional SARS-CoV-2-specific T cells), despite preserved humoral immunity. In conclusion, these data suggest a link between HIV-related T cell dysfunction and poor control over SARS-CoV-2 replication/dissemination that may in turn influence COVID-19 severity in PLWH., Competing Interests: The authors declare no conflict of interest related to this work., (© 2023 The Authors.)

Published
2023
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47. Failure of CD4+ T-cell Recovery upon Virally-Effective cART: an Enduring Gap in the Understanding of HIV+ Immunological non-Responders.

Author

Bono V, Augello M, Tincati C, and Marchetti G

Subjects
CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Humans, Viral Load, Antiretroviral Therapy, Highly Active adverse effects, HIV Infections drug therapy
Abstract

The introduction of cART in the treatment of HIV infection has significantly decreased morbidity and mortality by inducing suppression of viral replication and recovery of CD4+ T-cell counts. How- ever, about 30% of HIV-infected individuals fail to achieve normalization of CD4+ T-cell counts, de- spite antiretroviral therapy and complete suppression of the HIV load: these patients are referred to as "immunological non-responders". Several studies have shown an increased risk of clinical pro- gression to both AIDS and non-AIDS events as well as a higher mortality in these patients. The pathogenetic factors underlying this condition are multiple and none of these alone can exhaustive- ly explain the mechanism of incomplete immune reconstitution. In light of this, the purpose of the present review is to: i) describe in detail the pathogenetic mechanisms that contribute to scarce immune recovery; ii) discuss the higher morbidity and mortality which feature such a condition; iii) take stock of therapeutic strategies used in recent years for these patients.

Published
2022

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