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11. Letter to the Editor

Author

Sakurai, Ryota, Bonneau, Heidi N., Fitzgerald, Peter J., and Honda, Yasuhiro

Published
2008

16. Impact of Donor-Transmitted Atherosclerosis on Early Cardiac Allograft Vasculopathy: New Findings by Three-Dimensional Intravascular Ultrasound Analysis

Author

Yamasaki, Masao, primary, Sakurai, Ryota, additional, Hirohata, Atsushi, additional, Honda, Yasuhiro, additional, Bonneau, Heidi N., additional, Luikart, Helen, additional, Yock, Paul G., additional, Fitzgerald, Peter J., additional, Yeung, Alan C., additional, Valantine, Hannah A., additional, and Fearon, William F., additional

Published
2011
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18. Determinants of Lumen Loss Between Years 1 and 2 After Cardiac Transplantation

Author

Sakurai, Ryota, primary, Yamasaki, Masao, additional, Nakamura, Mamoo, additional, Hirohata, Atsushi, additional, Honda, Yasuhiro, additional, Bonneau, Heidi N., additional, Luikart, Helen, additional, Yock, Paul G., additional, Fitzgerald, Peter J., additional, Yeung, Alan C., additional, Valantine, Hannah A., additional, and Fearon, William F., additional

Published
2007
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19. Predictors of Edge Stenosis Following Sirolimus-Eluting Stent Deployment (A Quantitative Intravascular Ultrasound Analysis from the SIRIUS Trial)

Author

Sakurai, Ryota, primary, Ako, Junya, additional, Morino, Yoshihiro, additional, Sonoda, Shinjo, additional, Kaneda, Hideaki, additional, Terashima, Mitsuyasu, additional, Hassan, Ali H.M., additional, Leon, Martin B., additional, Moses, Jeffrey W., additional, Popma, Jeffrey J., additional, Bonneau, Heidi N., additional, Yock, Paul G., additional, Fitzgerald, Peter J., additional, and Honda, Yasuhiro, additional

Published
2005
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21. Comparison of temporary occlusion and aspiration system versus the conventional method during coronary stenting for acute myocardial infarction

Author

Kusuyama, Takanori, primary, Kataoka, Toru, additional, Iida, Hidetaka, additional, Uchida, Eiji, additional, Matsuura, Hitoe, additional, Tanaka, Hidemasa, additional, Sato, Hiroshi, additional, Shimodozono, Shinichi, additional, Bonneau, Heidi N., additional, Kobayashi, Yoshiki, additional, Yoshiyama, Minoru, additional, and Yoshikawa, Junichi, additional

Published
2004
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22. Impact of final stent dimensions on long-term results following sirolimus-eluting stent implantation

Author

Sonoda, Shinjo, primary, Morino, Yoshihiro, additional, Ako, Junya, additional, Terashima, Mitsuyasu, additional, Hassan, Ali H.M, additional, Bonneau, Heidi N, additional, Leon, Martin B, additional, Moses, Jeffrey W, additional, Yock, Paul G, additional, Honda, Yasuhiro, additional, Kuntz, Richard E, additional, and Fitzgerald, Peter J, additional

Published
2004
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24. Late incomplete apposition with excessive remodeling of the stented coronary artery following intravascular brachytherapy

Author

Okura, Hiroyuki, primary, Lee, David P., additional, Lo, Sydney, additional, Yeung, Alan C., additional, Honda, Yasuhiro, additional, Waksman, Ron, additional, Kaluza, Grzegorz L., additional, Ali, Nadir M., additional, Bonneau, Heidi N., additional, Yock, Paul G., additional, Raizner, Albert E., additional, Mintz, Gary S., additional, and Fitzgerald, Peter J., additional

Published
2003
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26. Relationship between neointimal regrowth and mechanism of acute lumen gain during the treatment of in-stent restenosis with or without supplementary intravascular radiation

Author

Morino, Yoshihiro, primary, Limpijankit, Thosaphol, additional, Honda, Yasuhiro, additional, Somrantin, Manoon, additional, Waksman, Ron, additional, Bonneau, Heidi N., additional, Yock, Paul G., additional, Mintz, Gary S., additional, and Fitzgerald, Peter J., additional

Published
2003
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28. Delivered Dose and Vascular Response After β-Radiation for In-Stent Restenosis

Author

Morino, Yoshihiro, primary, Kaneda, Hideaki, additional, Fox, Tim, additional, Takagi, Atsushi, additional, Hassan, Ali H.M., additional, Bonan, Raoul, additional, Crocker, Ian, additional, Lansky, Alexandra J., additional, Laskey, Warren K., additional, Suntharalingam, Mohan, additional, Bonneau, Heidi N., additional, Yock, Paul G., additional, Honda, Yasuhiro, additional, and Fitzgerald, Peter J., additional

Published
2002
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29. 7-Hexanoyltaxol–Eluting Stent for Prevention of Neointimal Growth

Author

Kataoka, Toru, primary, Grube, Eberhard, additional, Honda, Yasuhiro, additional, Morino, Yoshihiro, additional, Hur, Seung-Ho, additional, Bonneau, Heidi N., additional, Colombo, Antonio, additional, Di Mario, Carlo, additional, Guagliumi, Giulio, additional, Hauptmann, Karl E., additional, Pitney, Mark R., additional, Lansky, Alexandra J., additional, Stertzer, Simon H., additional, Yock, Paul G., additional, and Fitzgerald, Peter J., additional

Published
2002
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32. Percutaneous Coronary Sinus Approach to the Treatment of Mitral Regurgitation.

Author

Cannon, Christopher P., Herrmann, Howard C., Ikeno, Fumiaki, Honda, Yasuhiro, Bonneau, Heidi N., Hassan, Ali H. M., and Fitzgerald, Peter J.

Abstract

Mitral valve regurgitation (MR) is a common disease involving multiple etiologies. Whereas the structural causes include myxomatous degeneration, rheumatic changes, calcified annulus, infective endocarditis, and chordal rupture, functional MR is primarily the result of incomplete coaptation of normal mitral leaflets as a result of progressive mitral annular dilation, alteration in left ventricular (LV) geometry, and/or papillary muscle dysfunction (1-4). This secondary MR frequently accompanies acute ischemic or chronic heart failure (5) and triggers a vicious cycle of continuing volume overload, ventricular dilation, progression of annular dilation, and increased LV wall tension, thus further worsening MR and heart failure (6,7). In addition, this functional disorder can eventually lead to loss of systolic sphincteric contraction of mitral annulus and chordae tendinae retraction with fibrosis. [ABSTRACT FROM AUTHOR]

Published
2005
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35. Impact of Peri-Stent Remodeling on Restenosis

Author

Nakamura, Mamoo, primary, Yock, Paul G., additional, Bonneau, Heidi N., additional, Kitamura, Katsuhiro, additional, Aizawa, Tadanori, additional, Tamai, Hideo, additional, Fitzgerald, Peter J., additional, and Honda, Yasuhiro, additional

Published
2001
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38. Mechanisms of acute lumen gain following cutting balloon angioplasty in calcified and noncalcified lesions: An intravascular ultrasound study.

Author

Okura, Hiroyuki, Hayase, Motoya, Shimodozono, Shinichi, Kobayashi, Toru, Sano, Kazuya, Matsushita, Toyoaki, Kondo, Taizo, Kijima, Mikihiko, Nishikawa, Hideo, Kurogane, Hiroyuki, Aizawa, Tadanori, Hosokawa, Hiroaki, Suzuki, Takahiko, Yamaguchi, Tetsu, Bonneau, Heidi N., Yock, Paul G., and Fitzgerald, Peter J.

Published
2002
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39. Impact of final stent dimensions on long-term results following sirolimus-eluting stent implantation Serial intravascular ultrasound analysis from the sirius trial

Author

Sonoda, Shinjo, Morino, Yoshihiro, Ako, Junya, Terashima, Mitsuyasu, Hassan, Ali H.M, Bonneau, Heidi N, Leon, Martin B, Moses, Jeffrey W, Yock, Paul G, Honda, Yasuhiro, Kuntz, Richard E, and Fitzgerald, Peter J

Abstract

ObjectivesWe assessed the predictive value of minimum stent area (MSA) for long-term patency of sirolimus-eluting stents (SES) implantation compared to bare metal stents (BMS).BackgroundAlthough MSA is a consistent predictor of in-stent restenosis, its predictive value in BMS is still limited because of biologic variability in the restenosis process.MethodsFrom the SIRolImUS (SIRIUS) trial, 122 cases (SES: 72; BMS: 50) with complete serial intravascular ultrasound (IVUS) (baseline and 8-month follow-up) were analyzed. Postprocedure MSA and follow-up minimum lumen area (MLA) were obtained. Based on previous physiologic studies, adequate stent patency at follow-up was defined as MLA >4 mm2.ResultsIn both groups, a significant positive correlation was observed between baseline MSA and follow-up MLA (SES: p < 0.0001, BMS: p < 0.0001). However, SES showed higher correlation than BMS (0.8 vs. 0.65) with a higher regression coefficient (0.92 vs. 0.59). The sensitivity and specificity curves identified different optimal thresholds of MSA to predict adequate follow-up MLA: 5 mm2for SES and 6.5 mm2for BMS. The positive predictive values with these cutoff points were 90% and 56%, respectively.ConclusionsIn this SIRIUS IVUS substudy, SES reduced both biologic variability and restenosis, resulting in increased predictability of long-term stent patency with postprocedure MSA. In addition, SES had a considerably lower optimal MSA threshold compared to BMS.

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40. Late Incomplete Stent Apposition After Sirolimus-Eluting Stent Implantation A Serial Intravascular Ultrasound Analysis

Author

Ako, Junya, Morino, Yoshihiro, Honda, Yasuhiro, Hassan, Ali, Sonoda, Shinjo, Yock, Paul G., Leon, Martin B., Moses, Jeffrey W., Bonneau, Heidi N., and Fitzgerald, Peter J.

Subjects
surgical procedures, operative, cardiovascular diseases, equipment and supplies
Abstract

ObjectivesWe sought to identify the frequency of incomplete stent apposition (ISA) in sirolimus-eluting stents (SES) and clarify its findings and clinical sequelae.BackgroundLate-acquired ISA has been reported in bare-metal stents (BMS) and brachytherapy and recently in drug-eluting stents. However, the characteristics of late ISA in SES have not been clarified.MethodsFrom the SIRIUS trial, a randomized, multicenter study comparing SES and BMS, serial qualitative intravascular ultrasound (IVUS; at stent implantation and eight-month follow-up) was available in 141 patients (BMS: n = 61; SES: n = 80). The IVUS images were reviewed for the presence of ISA.ResultsIncomplete stent apposition at follow-up was observed in 19 patients (BMS: n = 6 [9.8%]; SES: n = 13 [16.3%]; p = NS). Among these, 12 had ISA after intervention and at follow-up (persistent ISA). Late-acquired ISA was seen in the remaining seven cases, all from the SES group (BMS: n = 0; SES: n = 7 [8.7%]; p < 0.05). In late-acquired ISA, there was an increase in external elastic membrane area (after intervention: 16.2 ± 2.7 m2; follow-up: 18.9 ± 3.6 mm2; p < 0.05). The location of stent-vessel wall separation was primarily at the stent edges in persistent ISA cases, whereas late-acquired ISA in SES occurred mostly in the mid portion of the stent. There were no negative clinical events reported for any ISA cases at 12-month clinical follow-up.ConclusionsLate ISA was observed in 8.7% of patients after SES implantation. There were no negative clinical events associated with this IVUS finding at 12-month clinical follow-up; however, careful long-term follow-up will be necessary.

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42. Taxol-based eluting stents from theory to human validation: clinical and intravascular ultrasound observations.

Author

Sonoda S, Honda Y, Kataoka T, Bonneau HN, Sudhir K, Yock PG, Mintz GS, and Fitzgerald PJ

Subjects
Blood Vessel Prosthesis Implantation, Cardiac Surgical Procedures, Clinical Trials as Topic, Coronary Restenosis diagnostic imaging, Coronary Restenosis prevention & control, Humans, Reproducibility of Results, Ultrasonography, Interventional, Angiogenesis Inhibitors pharmacology, Angiogenesis Inhibitors therapeutic use, Coated Materials, Biocompatible pharmacology, Coated Materials, Biocompatible therapeutic use, Paclitaxel pharmacology, Paclitaxel therapeutic use, Stents
Abstract

Treatment with antiproliferative drugs via coated stents appears to be a promising approach to both mechanically remodel target lesions and biologically reduce neointimal hyperplasia. Drug-eluting stents can maximize local drug effects and minimize the potential for systemic toxic effects. The purpose of this review is to describe the effects of a lipophilic microtubular inhibitor, paclitaxel, a strong antiproliferative agent under clinical investigation, and to define the vascular response to taxol-based eluting stents by intravascular ultrasound.

Published
2003

43. Arterial response during cutting balloon angioplasty: a volumetric intravascular ultrasound study.

Author

Liao CK, Bonneau HN, Yock PG, and Fitzgerald PJ

Subjects
Aged, Coronary Disease diagnostic imaging, Coronary Vessels physiopathology, Female, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Regional Blood Flow physiology, Vasodilation physiology, Angioplasty, Balloon methods, Coronary Disease therapy, Coronary Vessels diagnostic imaging, Ultrasonography, Interventional
Abstract

Background and Purpose: Previous studies have demonstrated that the mechanism of acute lumen enlargement after balloon angioplasty is a combination of vessel expansion and plaque redistribution, but not plaque compression. The purpose of this study was to clarify, from a three-dimensional aspect, the vascular response to cutting balloon angioplasty., Methods: Serial intravascular ultrasound (IVUS) studies, including pre- and post-intervention, were performed in 36 native coronary lesions treated with the cutting balloon device. External elastic membrane (EEM), lumen, and plaque + media cross-sectional area were measured at 16-frame intervals (30 frames = 1 mm) over a lesion length of 16 mm with the center on the smallest pre-intervention lumen area. Volumetric calculations were based on Simpson's rule., Results: EEM volume (261.16 +/- 89.59 vs. 279.59 +/- 85.92 mm3; p < 0.01) and lumen volume (106.48 +/- 37.83 v.s. 133.72 +/- 36.57 mm3; p < 0.01) significantly increased after cutting balloon angioplasty. Furthermore, the plaque + media volume throughout the lesion changed significantly after cutting balloon angioplasty (154.68 +/- 63.36 vs. 145.87 +/- 59.20 mm3; p < 0.01). The change in lumen volume correlated strongly with the change in EEM volume (r = 0.75; p < 0.01), but poorly with the change in plaque + media volume (r = 0.08; p = 0.64). Less longitudinal plaque redistribution was also observed throughout the vessel after angioplasty., Conclusion: The results of this study indicate that the predominant mechanism of lumen enlargement from cutting balloon angioplasty is vessel expansion, although total plaque mass reduction and longitudinal plaque redistribution do occur.

Published
2002

44. Delivered dose and vascular response after beta-radiation for in-stent restenosis: retrospective dosimetry and volumetric intravascular ultrasound analysis.

Author

Morino Y, Kaneda H, Fox T, Takagi A, Hassan AH, Bonan R, Crocker I, Lansky AJ, Laskey WK, Suntharalingam M, Bonneau HN, Yock PG, Honda Y, and Fitzgerald PJ

Subjects
Blood Vessel Prosthesis Implantation adverse effects, Brachytherapy methods, Cohort Studies, Coronary Angiography, Coronary Artery Disease diagnostic imaging, Coronary Vessels diagnostic imaging, Coronary Vessels drug effects, Coronary Vessels surgery, Dose-Response Relationship, Radiation, Female, Humans, Linear Models, Male, Middle Aged, Radiation Dosage, Radiometry, Retrospective Studies, Treatment Outcome, Ultrasonography, Interventional, Vascular Patency, Beta Particles therapeutic use, Brachytherapy standards, Coronary Artery Disease therapy, Coronary Restenosis radiotherapy, Stents adverse effects
Abstract

Background: Observations from previous intracoronary radiation therapy trials noted a considerable discrepancy between the prescribed radiation dose and the dose actually delivered. The aims of this study were to investigate the effect of actual delivered dose on vascular changes and to test the appropriateness of the current dose prescription., Methods and Results: Serial volumetric intravascular ultrasound (IVUS) analysis was performed in 30 in-stent restenosis cases treated with a 40-mm (90)Sr/Y source train. The fixed dose was prescribed at 2 mm from the centerline of the source train (18.4 Gy at 2 mm for reference diameter < or =3.35 mm and 23 Gy for diameter > or =3.36 mm). Only stent segments with full radiation coverage and device injury were enrolled and divided into 2-mm-long subsegments (n=202). D(S90)EEM (the minimum dose absorbed by 90% of the external elastic membrane surface) was calculated as the delivered dose corresponding to each segment, assuming that the radiation catheter occupied the same position in the vessel as the IVUS catheter. Mean D(S90)EEM of 23.5+/-5.82 Gy (range 12.3 to 41.7 Gy) was delivered to these subsegments. Overall, intimal hyperplasia volume remained constant from postintervention to follow-up (2.23+/-1.10 to 2.32+/-1.09 mm3/m; P=NS). Regression analysis revealed there was no correlation between delivered dose intensity and changes in intimal hyperplasia volume. No particular dose-dependent complications were appreciated in this delivered dose range., Conclusions: The current dose-prescription protocol of (90)Sr/Y radiation to native in-stent restenosis lesions may provide substantial inhibition of neointimal reproliferation regardless of the actual delivered dose intensity.

Published
2002
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