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11 results on '"Bonilla, Rene F."'

1. Early Circulating Tumor DNA Shedding Kinetics for Prediction of Platinum Sensitivity in Patients With Small Cell Lung Cancer.

Author

Murciano-Goroff, Yonina R., Hui, Angela B.-Y., Araujo Filho, Jose A., Hamilton, Emily G., Chabon, Jacob J., Moding, Everett J., Bonilla, Rene F., Lebow, Emily S., Gomez, Daniel, Rimner, Andreas, Ginsberg, Michelle S., Offin, Michael, Kundra, Ritika, Allaj, Viola, Norton, Larry, Reis-Filho, Jorge S., Razavi, Pedram, Drilon, Alexander, Jones, David R., and Isbell, James M.

Subjects
SMALL cell lung cancer, CIRCULATING tumor DNA, OVERALL survival, PROGRESSION-free survival, GENE frequency
Abstract

PURPOSE: Small cell lung cancer (SCLC) is characterized by rapid progression after platinum resistance. Circulating tumor (ctDNA) dynamics early in treatment may help determine platinum sensitivity. MATERIALS AND METHODS: Serial plasma samples were collected from patients receiving platinum-based chemotherapy for SCLC on the first 3 days of cycle one and on the first days of subsequent cycles with paired samples collected both before and again after infusions. Tumor-informed plasma analysis was carried out using CAncer Personalized Profiling by deep Sequencing (CAPP-Seq). The mean variant allele frequency (VAF) of all pretreatment mutations was tracked in subsequent blood draws and correlated with radiologic response. RESULTS: ctDNA kinetics were assessed in 122 samples from 21 patients. Pretreatment VAF did not differ significantly between patients who did and did not respond to chemotherapy (mean 22.5% v 4.6%, P =.17). A slight increase in ctDNA on cycle 1, day 1 immediately post-treatment was seen in six of the seven patients with available draws (fold change from baseline: 1.01-1.44), half of whom achieved a response. All patients who responded had a >2-fold decrease in mean VAF on cycle 2 day 1 (C2D1). Progression-free survival (PFS) and overall survival (OS) were significantly longer in patients with a >2-fold decrease in mean VAF after one treatment cycle (6.8 v 2.6 months, log-rank P =.0004 and 21.7 v 6.4 months, log rank P =.04, respectively). CONCLUSION: A >2-fold decrease in ctDNA concentration was observed by C2D1 in all patients who were sensitive to platinum-based therapy and was associated with longer PFS and OS. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Integrating genomic features for non-invasive early lung cancer detection

Author

Chabon, Jacob J., Hamilton, Emily G., Kurtz, David M., Esfahani, Mohammad S., Moding, Everett J., Stehr, Henning, Schroers-Martin, Joseph, Nabet, Barzin Y., Chen, Binbin, Chaudhuri, Aadel A., Liu, Chih Long, Hui, Angela B., Jin, Michael C., Azad, Tej D., Almanza, Diego, Jeon, Young-Jun, Nesselbush, Monica C., Co Ting Keh, Lyron, Bonilla, Rene F., Yoo, Christopher H., Ko, Ryan B., Chen, Emily L., Merriott, David J., Massion, Pierre P., Mansfield, Aaron S., Jen, Jin, Ren, Hong Z., Lin, Steven H., Costantino, Christina L., Burr, Risa, Tibshirani, Robert, Gambhir, Sanjiv S., Berry, Gerald J., Jensen, Kristin C., West, Robert B., Neal, Joel W., Wakelee, Heather A., Loo, Jr, Billy W., Kunder, Christian A., Leung, Ann N., Lui, Natalie S., Berry, Mark F., Shrager, Joseph B., Nair, Viswam S., Haber, Daniel A., Sequist, Lecia V., Alizadeh, Ash A., and Diehn, Maximilian

Published
2020
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3. Circulating tumor DNA dynamics predict benefit from consolidation immunotherapy in locally advanced non-small-cell lung cancer

Author

Moding, Everett J., Liu, Yufei, Nabet, Barzin Y., Chabon, Jacob J., Chaudhuri, Aadel A., Hui, Angela B., Bonilla, Rene F., Ko, Ryan B., Yoo, Christopher H., Gojenola, Linda, Jones, Carol D., He, Jianzhong, Qiao, Yawei, Xu, Ting, Heymach, John V., Tsao, Anne, Liao, Zhongxing, Gomez, Daniel R., Das, Millie, Padda, Sukhmani K., Ramchandran, Kavitha J., Neal, Joel W., Wakelee, Heather A., Loo, Jr, Billy W., Lin, Steven H., Alizadeh, Ash A., and Diehn, Maximilian

Published
2020
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4. Table S1 from Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., primary, Rizvi, Hira, primary, Chaudhuri, Aadel A., primary, Wells, Daniel K., primary, Dunphy, Mark P.S., primary, Chabon, Jacob J., primary, Liu, Chih Long, primary, Hui, Angela B., primary, Arbour, Kathryn C., primary, Luo, Jia, primary, Preeshagul, Isabel R., primary, Moding, Everett J., primary, Almanza, Diego, primary, Bonilla, Rene F., primary, Sauter, Jennifer L., primary, Choi, Hyejin, primary, Tenet, Megan, primary, Abu-Akeel, Mohsen, primary, Plodkowski, Andrew J., primary, Perez Johnston, Rocio, primary, Yoo, Christopher H., primary, Ko, Ryan B., primary, Stehr, Henning, primary, Gojenola, Linda, primary, Wakelee, Heather A., primary, Padda, Sukhmani K., primary, Neal, Joel W., primary, Chaft, Jamie E., primary, Kris, Mark G., primary, Rudin, Charles M., primary, Merghoub, Taha, primary, Li, Bob T., primary, Alizadeh, Ash A., primary, and Diehn, Maximilian, primary

Published
2023
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5. Supplementary Tables S2-S7 from Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., primary, Rizvi, Hira, primary, Chaudhuri, Aadel A., primary, Wells, Daniel K., primary, Dunphy, Mark P.S., primary, Chabon, Jacob J., primary, Liu, Chih Long, primary, Hui, Angela B., primary, Arbour, Kathryn C., primary, Luo, Jia, primary, Preeshagul, Isabel R., primary, Moding, Everett J., primary, Almanza, Diego, primary, Bonilla, Rene F., primary, Sauter, Jennifer L., primary, Choi, Hyejin, primary, Tenet, Megan, primary, Abu-Akeel, Mohsen, primary, Plodkowski, Andrew J., primary, Perez Johnston, Rocio, primary, Yoo, Christopher H., primary, Ko, Ryan B., primary, Stehr, Henning, primary, Gojenola, Linda, primary, Wakelee, Heather A., primary, Padda, Sukhmani K., primary, Neal, Joel W., primary, Chaft, Jamie E., primary, Kris, Mark G., primary, Rudin, Charles M., primary, Merghoub, Taha, primary, Li, Bob T., primary, Alizadeh, Ash A., primary, and Diehn, Maximilian, primary

Published
2023
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6. Supplementary Data from Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., primary, Rizvi, Hira, primary, Chaudhuri, Aadel A., primary, Wells, Daniel K., primary, Dunphy, Mark P.S., primary, Chabon, Jacob J., primary, Liu, Chih Long, primary, Hui, Angela B., primary, Arbour, Kathryn C., primary, Luo, Jia, primary, Preeshagul, Isabel R., primary, Moding, Everett J., primary, Almanza, Diego, primary, Bonilla, Rene F., primary, Sauter, Jennifer L., primary, Choi, Hyejin, primary, Tenet, Megan, primary, Abu-Akeel, Mohsen, primary, Plodkowski, Andrew J., primary, Perez Johnston, Rocio, primary, Yoo, Christopher H., primary, Ko, Ryan B., primary, Stehr, Henning, primary, Gojenola, Linda, primary, Wakelee, Heather A., primary, Padda, Sukhmani K., primary, Neal, Joel W., primary, Chaft, Jamie E., primary, Kris, Mark G., primary, Rudin, Charles M., primary, Merghoub, Taha, primary, Li, Bob T., primary, Alizadeh, Ash A., primary, and Diehn, Maximilian, primary

Published
2023
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7. Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition

Author

Nabet, Barzin Y., primary, Esfahani, Mohammad S., additional, Moding, Everett J., additional, Hamilton, Emily G., additional, Chabon, Jacob J., additional, Rizvi, Hira, additional, Steen, Chloe B., additional, Chaudhuri, Aadel A., additional, Liu, Chih Long, additional, Hui, Angela B., additional, Almanza, Diego, additional, Stehr, Henning, additional, Gojenola, Linda, additional, Bonilla, Rene F., additional, Jin, Michael C., additional, Jeon, Young-Jun, additional, Tseng, Diane, additional, Liu, Cailian, additional, Merghoub, Taha, additional, Neal, Joel W., additional, Wakelee, Heather A., additional, Padda, Sukhmani K., additional, Ramchandran, Kavitha J., additional, Das, Millie, additional, Plodkowski, Andrew J., additional, Yoo, Christopher, additional, Chen, Emily L., additional, Ko, Ryan B., additional, Newman, Aaron M., additional, Hellmann, Matthew D., additional, Alizadeh, Ash A., additional, and Diehn, Maximilian, additional

Published
2020
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8. Abstract 5666: A noninvasive approach for early prediction of therapeutic benefit from immune checkpoint inhibition for lung cancer

Author

Nabet, Barzin Y., primary, Esfahani, Mohammad S., additional, Hamilton, Emily G., additional, Chabon, Jacob J., additional, Moding, Everett J., additional, Rizvi, Hira, additional, Steen, Chloe B., additional, Chaudhuri, Aadel A., additional, Liu, Chih Long, additional, Hui, Angela B., additional, Stehr, Henning, additional, Goljenola, Linda, additional, Jin, Michael C., additional, Jeon, Young-Jun, additional, Tseng, Diane, additional, Merghoub, Taha, additional, Neal, Joel W., additional, Wakelee, Heather A., additional, Padda, Sukhmani K., additional, Ramchandran, Kavitha J., additional, Das, Millie, additional, Bonilla, Rene F., additional, Yoo, Christopher, additional, Chen, Emily L., additional, Ko, Ryan B., additional, Newman, Aaron M., additional, Hellmann, Matthew D., additional, Alizadeh, Ash A., additional, and Diehn, Maximilian, additional

Published
2020
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9. Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Author

Hellmann, Matthew D., primary, Nabet, Barzin Y., additional, Rizvi, Hira, additional, Chaudhuri, Aadel A., additional, Wells, Daniel K., additional, Dunphy, Mark P.S., additional, Chabon, Jacob J., additional, Liu, Chih Long, additional, Hui, Angela B., additional, Arbour, Kathryn C., additional, Luo, Jia, additional, Preeshagul, Isabel R., additional, Moding, Everett J., additional, Almanza, Diego, additional, Bonilla, Rene F., additional, Sauter, Jennifer L., additional, Choi, Hyejin, additional, Tenet, Megan, additional, Abu-Akeel, Mohsen, additional, Plodkowski, Andrew J., additional, Perez Johnston, Rocio, additional, Yoo, Christopher H., additional, Ko, Ryan B., additional, Stehr, Henning, additional, Gojenola, Linda, additional, Wakelee, Heather A., additional, Padda, Sukhmani K., additional, Neal, Joel W., additional, Chaft, Jamie E., additional, Kris, Mark G., additional, Rudin, Charles M., additional, Merghoub, Taha, additional, Li, Bob T., additional, Alizadeh, Ash A., additional, and Diehn, Maximilian, additional

Published
2020
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11. A novel protocol for studying bee cognition in the wild.

Author

Muth, Felicity, Cooper, Trenton R., Bonilla, Rene F., and Leonard, Anne S.

Subjects
NATURAL selection, CAPTIVE wild animals, NATURE, ECOLOGY, BUMBLEBEES, POLLINATION
Abstract

Abstract: Understanding how animals perceive, learn and remember stimuli is critical for understanding both how cognition is shaped by natural selection, and how ecological factors impact behaviour. However, the majority of studies on cognition involve captive animals in laboratory settings. While controlled settings are required to accurately measure aspects of cognition, they may not yield realistic estimates of learning performance in natural environments. Wild bees offer a useful system in which to study cognitive ecology and comparative cognition more broadly: they encompass around 20,000 species globally, varying in characteristics such as life‐history strategy, degree of sociality and dietary specialization. Yet, the limited number of protocols currently available for studying insect cognition has restricted research to a few commercially available bee species, in almost exclusively laboratory settings. We present a protocol (Free‐Moving Proboscis Extension Response [FMPER]) to measure wild bees’ colour preferences, learning performance and memory. We first used laboratory‐reared bumblebees Bombus impatiens to establish that FMPER yielded results consistent with learning theory. We then successfully tested wild honeybees Apis mellifera in the laboratory and Bombus vosnesenskii at field sites. Free‐Moving Proboscis Extension Response is straightforward to implement, is low cost, and may be readily adapted to other flower‐visiting insects. We believe it will be useful to a broad range of evolutionary biologists, behavioural ecologists and pollination ecologists interested in measuring cognitive performance in the wild and across a broader range of species. [ABSTRACT FROM AUTHOR]

Published
2018
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