1,165 results on '"Bonilha, Leonardo"'
Search Results
2. The Aphasia Recovery Cohort, an open-source chronic stroke repository
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Gibson, Makayla, Newman-Norlund, Roger, Bonilha, Leonardo, Fridriksson, Julius, Hickok, Gregory, Hillis, Argye E., den Ouden, Dirk-Bart, and Rorden, Christopher
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- 2024
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3. Concurrent tDCS-fMRI after stroke reveals link between attention network organization and motor improvement
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Salazar, Claudia A., Welsh, James M., Lench, Daniel, Harmsen, Irene E., Jensen, Jens H., Grewal, Parneet, Yazdani, Milad, Al Kasab, Sami, Spiotta, Alex, Bonilha, Leonardo, George, Mark S., Kautz, Steven A., and Rowland, Nathan C.
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- 2024
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4. The stroke outcome optimization project: Acute ischemic strokes from a comprehensive stroke center
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Absher, John, Goncher, Sarah, Newman-Norlund, Roger, Perkins, Nicholas, Yourganov, Grigori, Vargas, Jan, Sivakumar, Sanjeev, Parti, Naveen, Sternberg, Shannon, Teghipco, Alex, Gibson, Makayla, Wilson, Sarah, Bonilha, Leonardo, and Rorden, Chris
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- 2024
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5. Distinct brain morphometry patterns revealed by deep learning improve prediction of post-stroke aphasia severity
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Teghipco, Alex, Newman-Norlund, Roger, Fridriksson, Julius, Rorden, Christopher, and Bonilha, Leonardo
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- 2024
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6. Regional brain aging: premature aging of the domain general system predicts aphasia severity
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Busby, Natalie, Newman-Norlund, Sarah, Sayers, Sara, Rorden, Chris, Newman-Norlund, Roger, Wilmskoetter, Janina, Roth, Rebecca, Wilson, Sarah, Schwen-Blackett, Deena, Kristinsson, Sigfus, Teghipco, Alex, Fridriksson, Julius, and Bonilha, Leonardo
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- 2024
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7. Predicting Outcomes of Language Rehabilitation: Prognostic Factors for Immediate and Long-Term Outcomes after Aphasia Therapy
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Kristinsson, Sigfus, Basilakos, Alexandra, den Ouden, Dirk B., Cassarly, Christy, Spell, Leigh Ann, Bonilha, Leonardo, Rorden, Chris, Hillis, Argye E., Hickok, Gregory, Johnson, Lisa, Busby, Natalie, Walker, Grant M., McLain, Alexander, and Fridriksson, Julius
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Background: Aphasia therapy is an effective approach to improve language function in chronic aphasia. However, it remains unclear what prognostic factors facilitate therapy response at the individual level. Here, we utilized data from the POLAR (Predicting Outcomes of Language Rehabilitation in Aphasia) trial to (a) determine therapy-induced change in confrontation naming and long-term maintenance of naming gains and (b) examine the extent to which aphasia severity, age, education, time postonset, and cognitive reserve predict naming gains at 1 week, 1 month, and 6 months posttherapy. Method: A total of 107 participants with chronic ([greater than or equal to] 12 months poststroke) aphasia underwent extensive case history, cognitive-linguistic testing, and a neuroimaging workup prior to receiving 6 weeks of impairment-based language therapy. Therapy-induced change in naming performance (measured as raw change on the 175-item Philadelphia Naming Test [PNT]) was assessed 1 week after therapy and at follow-up time points 1 month and 6 months after therapy completion. Change in naming performance over time was evaluated using paired t tests, and linear mixed-effects models were constructed to examine the association between prognostic factors and therapy outcomes. Results: Naming performance was improved by 5.9 PNT items (Cohen's d = 0.56, p < 0.001) 1 week after therapy and by 6.4 (d = 0.66, p < 0.001) and 7.5 (d = 0.65, p < 0.001) PNT items at 1 month and 6 months after therapy completion, respectively. Aphasia severity emerged as the strongest predictor of naming improvement recovery across time points; "mild" ([beta] = 5.85-9.02) and "moderate" ([beta] = 9.65-11.54) impairment predicted better recovery than "severe" ([beta] = 1.31-3.37) and "very severe" ([beta] = 0.20-0.32) aphasia. Age was an emergent prognostic factor for recovery 1 month ([beta] = -0.14) and 6 months ([beta] = -0.20) after therapy, and time postonset ([beta] = -0.05) was associated with retention of naming gains at 6 months posttherapy. Conclusions: These results suggest that therapy-induced naming improvement is predictable based on several easily measurable prognostic factors. Broadly speaking, these results suggest that prognostication procedures in aphasia therapy can be improved and indicate that personalization of therapy is a realistic goal in the near future.
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- 2023
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8. Event‐based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross‐sectional data
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Lopez, Seymour M, Aksman, Leon M, Oxtoby, Neil P, Vos, Sjoerd B, Rao, Jun, Kaestner, Erik, Alhusaini, Saud, Alvim, Marina, Bender, Benjamin, Bernasconi, Andrea, Bernasconi, Neda, Bernhardt, Boris, Bonilha, Leonardo, Caciagli, Lorenzo, Caldairou, Benoit, Caligiuri, Maria Eugenia, Calvet, Angels, Cendes, Fernando, Concha, Luis, Conde‐Blanco, Estefania, Davoodi‐Bojd, Esmaeil, de Bézenac, Christophe, Delanty, Norman, Desmond, Patricia M, Devinsky, Orrin, Domin, Martin, Duncan, John S, Focke, Niels K, Foley, Sonya, Fortunato, Francesco, Galovic, Marian, Gambardella, Antonio, Gleichgerrcht, Ezequiel, Guerrini, Renzo, Hamandi, Khalid, Ives‐Deliperi, Victoria, Jackson, Graeme D, Jahanshad, Neda, Keller, Simon S, Kochunov, Peter, Kotikalapudi, Raviteja, Kreilkamp, Barbara AK, Labate, Angelo, Larivière, Sara, Lenge, Matteo, Lui, Elaine, Malpas, Charles, Martin, Pascal, Mascalchi, Mario, Medland, Sarah E, Meletti, Stefano, Morita‐Sherman, Marcia E, Owen, Thomas W, Richardson, Mark, Riva, Antonella, Rüber, Theodor, Sinclair, Ben, Soltanian‐Zadeh, Hamid, Stein, Dan J, Striano, Pasquale, Taylor, Peter N, Thomopoulos, Sophia I, Thompson, Paul M, Tondelli, Manuela, Vaudano, Anna Elisabetta, Vivash, Lucy, Wang, Yujiang, Weber, Bernd, Whelan, Christopher D, Wiest, Roland, Winston, Gavin P, Yasuda, Clarissa Lin, McDonald, Carrie R, Alexander, Daniel C, Sisodiya, Sanjay M, Altmann, Andre, Bargalló, Núria, Bartolini, Emanuele, O’Brien, Terence J, and Thomas, Rhys H
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Brain Disorders ,Epilepsy ,Neurodegenerative ,Neurosciences ,Clinical Research ,Biomedical Imaging ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Good Health and Well Being ,Atrophy ,Biomarkers ,Cross-Sectional Studies ,Epilepsy ,Temporal Lobe ,Hippocampus ,Humans ,Magnetic Resonance Imaging ,Sclerosis ,disease progression ,duration of illness ,event-based model ,MTLE ,patient staging ,ENIGMA-Epilepsy Working Group ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
ObjectiveRecent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features.MethodsWe extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS and 1625 healthy controls from 25 centers. Features with a moderate case-control effect size (Cohen d ≥ .5) were used to train an event-based model (EBM), which estimates a sequence of disease-specific biomarker changes from cross-sectional data and assigns a biomarker-based fine-grained disease stage to individual patients. We tested for associations between EBM disease stage and duration of epilepsy, age at onset, and antiseizure medicine (ASM) resistance.ResultsIn MTLE-HS, decrease in ipsilateral hippocampal volume along with increased asymmetry in hippocampal volume was followed by reduced thickness in neocortical regions, reduction in ipsilateral thalamus volume, and finally, increase in ipsilateral lateral ventricle volume. EBM stage was correlated with duration of illness (Spearman ρ = .293, p = 7.03 × 10-16 ), age at onset (ρ = -.18, p = 9.82 × 10-7 ), and ASM resistance (area under the curve = .59, p = .043, Mann-Whitney U test). However, associations were driven by cases assigned to EBM Stage 0, which represents MTLE-HS with mild or nondetectable abnormality on T1W MRI.SignificanceFrom cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features.
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- 2022
9. Acute seizures after spontaneous intracerebral hemorrhage in young individuals: 11-year trends and association with mortality
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Lekoubou, Alain, Cohrs, Austin, Dejuk, Mariana, Hong, Jinpyo, Sen, Souvik, Bonilha, Leonardo, and Chinchilli, Vernon M.
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- 2024
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10. Can machine learning predict late seizures after intracerebral hemorrhages? Evidence from real-world data
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Lekoubou, Alain, Petucci, Justin, Femi Ajala, Temitope, Katoch, Avnish, Hong, Jinpyo, Sen, Souvik, Bonilha, Leonardo, Chinchilli, Vernon M., and Honavar, Vasant
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- 2024
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11. The impact of age-related hearing loss on cognitive decline: The mediating role of brain age gap
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Nemati, Samaneh, Arjmandi, Meisam, Busby, Natalie, Bonilha, Leonardo, and Fridriksson, Julius
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- 2024
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12. Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy
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Park, Bo-yong, Larivière, Sara, Rodríguez-Cruces, Raul, Royer, Jessica, Tavakol, Shahin, Wang, Yezhou, Caciagli, Lorenzo, Caligiuri, Maria Eugenia, Gambardella, Antonio, Concha, Luis, Keller, Simon S, Cendes, Fernando, Alvim, Marina KM, Yasuda, Clarissa, Bonilha, Leonardo, Gleichgerrcht, Ezequiel, Focke, Niels K, Kreilkamp, Barbara AK, Domin, Martin, von Podewils, Felix, Langner, Soenke, Rummel, Christian, Rebsamen, Michael, Wiest, Roland, Martin, Pascal, Kotikalapudi, Raviteja, Bender, Benjamin, O’Brien, Terence J, Law, Meng, Sinclair, Benjamin, Vivash, Lucy, Kwan, Patrick, Desmond, Patricia M, Malpas, Charles B, Lui, Elaine, Alhusaini, Saud, Doherty, Colin P, Cavalleri, Gianpiero L, Delanty, Norman, Kälviäinen, Reetta, Jackson, Graeme D, Kowalczyk, Magdalena, Mascalchi, Mario, Semmelroch, Mira, Thomas, Rhys H, Soltanian-Zadeh, Hamid, Davoodi-Bojd, Esmaeil, Zhang, Junsong, Lenge, Matteo, Guerrini, Renzo, Bartolini, Emanuele, Hamandi, Khalid, Foley, Sonya, Weber, Bernd, Depondt, Chantal, Absil, Julie, Carr, Sarah JA, Abela, Eugenio, Richardson, Mark P, Devinsky, Orrin, Severino, Mariasavina, Striano, Pasquale, Parodi, Costanza, Tortora, Domenico, Hatton, Sean N, Vos, Sjoerd B, Duncan, John S, Galovic, Marian, Whelan, Christopher D, Bargalló, Núria, Pariente, Jose, Conde-Blanco, Estefania, Vaudano, Anna Elisabetta, Tondelli, Manuela, Meletti, Stefano, Kong, Xiang‐Zhen, Francks, Clyde, Fisher, Simon E, Caldairou, Benoit, Ryten, Mina, Labate, Angelo, Sisodiya, Sanjay M, Thompson, Paul M, McDonald, Carrie R, Bernasconi, Andrea, Bernasconi, Neda, and Bernhardt, Boris C
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Epilepsy ,Neurodegenerative ,Clinical Research ,Brain Disorders ,Neurosciences ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Atrophy ,Connectome ,Epilepsy ,Temporal Lobe ,Hippocampus ,Humans ,Magnetic Resonance Imaging ,temporal lobe epilepsy ,asymmetry ,cortical thickness ,multi-site ,gradients ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine our notion of the neuropathology of temporal lobe epilepsy and may inform future discovery and validation of complementary MRI biomarkers in temporal lobe epilepsy.
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- 2022
13. Dynamic network properties of the superior temporal gyrus mediate the impact of brain age gap on chronic aphasia severity
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Wilmskoetter, Janina, Busby, Natalie, He, Xiaosong, Caciagli, Lorenzo, Roth, Rebecca, Kristinsson, Sigfus, Davis, Kathryn A., Rorden, Chris, Bassett, Dani S., Fridriksson, Julius, and Bonilha, Leonardo
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- 2023
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14. MRI-based deep learning can discriminate between temporal lobe epilepsy, Alzheimer’s disease, and healthy controls
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Chang, Allen J., Roth, Rebecca, Bougioukli, Eleni, Ruber, Theodor, Keller, Simon S., Drane, Daniel L., Gross, Robert E., Welsh, James, Abrol, Anees, Calhoun, Vince, Karakis, Ioannis, Kaestner, Erik, Weber, Bernd, McDonald, Carrie, Gleichgerrcht, Ezequiel, and Bonilha, Leonardo
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- 2023
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15. The ENIGMA‐Epilepsy working group: Mapping disease from large data sets
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Sisodiya, Sanjay M, Whelan, Christopher D, Hatton, Sean N, Huynh, Khoa, Altmann, Andre, Ryten, Mina, Vezzani, Annamaria, Caligiuri, Maria Eugenia, Labate, Angelo, Gambardella, Antonio, Ives‐Deliperi, Victoria, Meletti, Stefano, Munsell, Brent C, Bonilha, Leonardo, Tondelli, Manuela, Rebsamen, Michael, Rummel, Christian, Vaudano, Anna Elisabetta, Wiest, Roland, Balachandra, Akshara R, Bargalló, Núria, Bartolini, Emanuele, Bernasconi, Andrea, Bernasconi, Neda, Bernhardt, Boris, Caldairou, Benoit, Carr, Sarah JA, Cavalleri, Gianpiero L, Cendes, Fernando, Concha, Luis, Desmond, Patricia M, Domin, Martin, Duncan, John S, Focke, Niels K, Guerrini, Renzo, Hamandi, Khalid, Jackson, Graeme D, Jahanshad, Neda, Kälviäinen, Reetta, Keller, Simon S, Kochunov, Peter, Kowalczyk, Magdalena A, Kreilkamp, Barbara AK, Kwan, Patrick, Lariviere, Sara, Lenge, Matteo, Lopez, Seymour M, Martin, Pascal, Mascalchi, Mario, Moreira, José CV, Morita‐Sherman, Marcia E, Pardoe, Heath R, Pariente, Jose C, Raviteja, Kotikalapudi, Rocha, Cristiane S, Rodríguez‐Cruces, Raúl, Seeck, Margitta, Semmelroch, Mira KHG, Sinclair, Benjamin, Soltanian‐Zadeh, Hamid, Stein, Dan J, Striano, Pasquale, Taylor, Peter N, Thomas, Rhys H, Thomopoulos, Sophia I, Velakoulis, Dennis, Vivash, Lucy, Weber, Bernd, Yasuda, Clarissa Lin, Zhang, Junsong, Thompson, Paul M, McDonald, Carrie R, Abela, Eugenio, Absil, Julie, Adams, Sophia, Alhusaini, Saud, Alvim, Marina, Balestrini, Simona, Bender, Benjamin, Bergo, Felipe, Bernardes, Tauana, Calvo, Anna, Carreno, Mar, Cherubini, Andrea, David, Philippe, Davoodi‐Bojd, Esmaeil, Delanty, Norman, Depondt, Chantal, Devinsky, Orrin, Doherty, Colin, França, Wendy Caroline, Franceschet, Leticia, Hibar, Derrek P, Ishikawa, Akari, Kaestner, Erik, Langner, Soenke, Liu, Min, Mirandola, Laura, Naylor, Jillian, and Nazem‐Zadeh, Mohammad‐reza
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Brain Disorders ,Biomedical Imaging ,Neurosciences ,Epilepsy ,Neurodegenerative ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,covariance ,deep learning ,DTI ,event-based modeling ,gene expression ,genetics ,imaging ,MRI ,quantitative ,rsfMRI ,ENIGMA Consortium Epilepsy Working Group ,Cognitive Sciences ,Experimental Psychology - Abstract
Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller-scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well-established by the ENIGMA Consortium, ENIGMA-Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event-based modeling analysis. We explore age of onset- and duration-related features, as well as phenomena-specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA-Epilepsy.
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- 2022
16. Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
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Larivière, Sara, Royer, Jessica, Rodríguez-Cruces, Raúl, Paquola, Casey, Caligiuri, Maria Eugenia, Gambardella, Antonio, Concha, Luis, Keller, Simon S, Cendes, Fernando, Yasuda, Clarissa L, Bonilha, Leonardo, Gleichgerrcht, Ezequiel, Focke, Niels K, Domin, Martin, von Podewills, Felix, Langner, Soenke, Rummel, Christian, Wiest, Roland, Martin, Pascal, Kotikalapudi, Raviteja, O’Brien, Terence J, Sinclair, Benjamin, Vivash, Lucy, Desmond, Patricia M, Lui, Elaine, Vaudano, Anna Elisabetta, Meletti, Stefano, Tondelli, Manuela, Alhusaini, Saud, Doherty, Colin P, Cavalleri, Gianpiero L, Delanty, Norman, Kälviäinen, Reetta, Jackson, Graeme D, Kowalczyk, Magdalena, Mascalchi, Mario, Semmelroch, Mira, Thomas, Rhys H, Soltanian-Zadeh, Hamid, Davoodi-Bojd, Esmaeil, Zhang, Junsong, Winston, Gavin P, Griffin, Aoife, Singh, Aditi, Tiwari, Vijay K, Kreilkamp, Barbara AK, Lenge, Matteo, Guerrini, Renzo, Hamandi, Khalid, Foley, Sonya, Rüber, Theodor, Weber, Bernd, Depondt, Chantal, Absil, Julie, Carr, Sarah JA, Abela, Eugenio, Richardson, Mark P, Devinsky, Orrin, Severino, Mariasavina, Striano, Pasquale, Tortora, Domenico, Kaestner, Erik, Hatton, Sean N, Vos, Sjoerd B, Caciagli, Lorenzo, Duncan, John S, Whelan, Christopher D, Thompson, Paul M, Sisodiya, Sanjay M, Bernasconi, Andrea, Labate, Angelo, McDonald, Carrie R, Bernasconi, Neda, and Bernhardt, Boris C
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Neurodegenerative ,Genetics ,Neurosciences ,Brain Disorders ,Epilepsy ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Connectome ,Epilepsy ,Generalized ,Epilepsy ,Temporal Lobe ,Gene Expression ,Humans ,Immunoglobulin E ,Magnetic Resonance Imaging ,Nerve Net - Abstract
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.
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- 2022
17. Progressive lesion necrosis is related to increasing aphasia severity in chronic stroke
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Johnson, Lisa, Newman-Norlund, Roger, Teghipco, Alex, Rorden, Chris, Bonilha, Leonardo, and Fridriksson, Julius
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- 2024
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18. Individualized response to semantic vs. phonological aphasia therapies in stroke
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Kristinsson, Sigfus, Basilakos, Alexandra, Elm, Jordan, Spell, Leigh Ann, Bonilha, Leonardo, Rorden, Chris, Ouden, Dirk B den, Cassarly, Christy, Sen, Souvik, Hillis, Argye, Hickok, Greg, and Fridriksson, Julius
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Aphasia ,Neurosciences ,Clinical Research ,Stroke ,Brain Disorders ,Aging ,Rehabilitation ,Aetiology ,2.1 Biological and endogenous factors ,stroke ,aphasia ,aphasia therapy ,phonological therapy ,semantic therapy - Abstract
Attempts to personalize aphasia treatment to the extent where it is possible to reliably predict individual response to a particular treatment have yielded inconclusive results. The current study aimed to (i) compare the effects of phonologically versus semantically focussed naming treatment and (ii) examine biographical and neuropsychological baseline factors predictive of response to each treatment. One hundred and four individuals with chronic post-stroke aphasia underwent 3 weeks of phonologically focussed treatment and 3 weeks of semantically focussed treatment in an unblinded cross-over design. A linear mixed-effects model was used to compare the effects of treatment type on proportional change in correct naming across groups. Correlational analysis and stepwise regression models were used to examine biographical and neuropsychological predictors of response to phonological and semantic treatment across all participants. Last, chi-square tests were used to explore the association between treatment response and phonological and semantic deficit profiles. Semantically focussed treatment was found to be more effective at the group-level, independently of treatment order (P = 0.041). Overall, milder speech and language impairment predicted good response to semantic treatment (r range: 0.256-0.373) across neuropsychological tasks. The Western Aphasia Battery-Revised Spontaneous Speech score emerged as the strongest predictor of semantic treatment response (R 2 = 0.188). Severity of stroke symptoms emerged as the strongest predictor of phonological treatment response (R 2 = 0.103). Participants who showed a good response to semantic treatment were more likely to present with fluent speech compared to poor responders (P = 0.005), whereas participants who showed a good response to phonological treatment were more likely to present with apraxia of speech (P = 0.020). These results suggest that semantic treatment may be more beneficial to the improvement of naming performance in aphasia than phonological treatment, at the group-level. In terms of personalized predictors, participants with relatively mild impairments and fluent speech responded better to semantic treatment, while phonological treatment benefitted participants with more severe impairments and apraxia of speech.
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- 2021
19. Network coupling and surgical treatment response in temporal lobe epilepsy: A proof-of-concept study
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Chang, Allen J., Roth, Rebecca W., Gong, Ruxue, Gross, Robert E., Harmsen, Irene, Parashos, Alexandra, Revell, Andrew, Davis, Kathryn A., Bonilha, Leonardo, and Gleichgerrcht, Ezequiel
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- 2023
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20. White matter hyperintensity load mediates the relationship between age and cognition
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Busby, Natalie, Wilson, Sarah, Wilmskoetter, Janina, Newman-Norlund, Roger, Sayers, Sara, Newman-Norlund, Sarah, Roth, Rebecca, Rorden, Chris, Fridriksson, Julius, and Bonilha, Leonardo
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- 2023
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21. Longitudinal Progression of White Matter Hyperintensity Severity in Chronic Stroke Aphasia
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Busby, Natalie, Newman-Norlund, Roger, Wilmskoetter, Janina, Johnson, Lisa, Rorden, Chris, Gibson, Makayla, Roth, Rebecca, Wilson, Sarah, Fridriksson, Julius, and Bonilha, Leonardo
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- 2023
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22. Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study
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Gleichgerrcht, Ezequiel, Munsell, Brent C, Alhusaini, Saud, Alvim, Marina KM, Bargalló, Núria, Bender, Benjamin, Bernasconi, Andrea, Bernasconi, Neda, Bernhardt, Boris, Blackmon, Karen, Caligiuri, Maria Eugenia, Cendes, Fernando, Concha, Luis, Desmond, Patricia M, Devinsky, Orrin, Doherty, Colin P, Domin, Martin, Duncan, John S, Focke, Niels K, Gambardella, Antonio, Gong, Bo, Guerrini, Renzo, Hatton, Sean N, Kälviäinen, Reetta, Keller, Simon S, Kochunov, Peter, Kotikalapudi, Raviteja, Kreilkamp, Barbara AK, Labate, Angelo, Langner, Soenke, Larivière, Sara, Lenge, Matteo, Lui, Elaine, Martin, Pascal, Mascalchi, Mario, Meletti, Stefano, O'Brien, Terence J, Pardoe, Heath R, Pariente, Jose C, Rao, Jun Xian, Richardson, Mark P, Rodríguez-Cruces, Raúl, Rüber, Theodor, Sinclair, Ben, Soltanian-Zadeh, Hamid, Stein, Dan J, Striano, Pasquale, Taylor, Peter N, Thomas, Rhys H, Vaudano, Anna Elisabetta, Vivash, Lucy, von Podewills, Felix, Vos, Sjoerd B, Weber, Bernd, Yao, Yi, Yasuda, Clarissa Lin, Zhang, Junsong, Thompson, Paul M, Sisodiya, Sanjay M, McDonald, Carrie R, Bonilha, Leonardo, Group, ENIGMA-Epilepsy Working, Altmann, Andre, Depondt, Chantal, Galovic, Marian, Thomopoulos, Sophia I, and Wiest, Roland
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Biomedical Imaging ,Neurodegenerative ,Neurosciences ,Brain Disorders ,Prevention ,Epilepsy ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Artificial Intelligence ,Brain ,Epilepsy ,Temporal Lobe ,Hippocampus ,Humans ,Magnetic Resonance Imaging ,Sclerosis ,Support Vector Machine ,Temporal lobe epilepsy ,Machine learning ,Artificial inteligence ,ENIGMA-Epilepsy Working Group - Abstract
Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for patients with temporal lobe epilepsy (TLE). The role of machine learning and artificial intelligence to increase detection of brain abnormalities in TLE remains inconclusive. We used support vector machine (SV) and deep learning (DL) models based on region of interest (ROI-based) structural (n = 336) and diffusion (n = 863) brain MRI data from patients with TLE with ("lesional") and without ("non-lesional") radiographic features suggestive of underlying hippocampal sclerosis from the multinational (multi-center) ENIGMA-Epilepsy consortium. Our data showed that models to identify TLE performed better or similar (68-75%) compared to models to lateralize the side of TLE (56-73%, except structural-based) based on diffusion data with the opposite pattern seen for structural data (67-75% to diagnose vs. 83% to lateralize). In other aspects, structural and diffusion-based models showed similar classification accuracies. Our classification models for patients with hippocampal sclerosis were more accurate (68-76%) than models that stratified non-lesional patients (53-62%). Overall, SV and DL models performed similarly with several instances in which SV mildly outperformed DL. We discuss the relative performance of these models with ROI-level data and the implications for future applications of machine learning and artificial intelligence in epilepsy care.
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- 2021
23. Withdrawal of antiseizure medications after MRI–Guided laser interstitial thermal therapy in extra-temporal lobe epilepsy
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Athreya, Arjun, Matthews, Rebecca E., Drane, Daniel L., Bonilha, Leonardo, Willie, Jon T., Gross, Robert E., and Karakis, Ioannis
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- 2023
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24. Associations of small vessel disease and acute symptomatic seizures in ischemic stroke patients
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Lekoubou, Alain, Ssentongo, Paddy, Maffie, Jonathon, Debroy, Kunal, Kwon, Michelle, Nguyen, Clever, Pelton, Matthew, Watt, Benjamin, Ceasar, Justin, Dinunno, Nadia, Satyasi, Vivek, Pascal Kengne, Andre, Bonilha, Leonardo, and Chinchilli, Vernon M.
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- 2023
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25. Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study
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Larivière, Sara, Rodríguez-Cruces, Raúl, Royer, Jessica, Caligiuri, Maria Eugenia, Gambardella, Antonio, Concha, Luis, Keller, Simon S, Cendes, Fernando, Yasuda, Clarissa, Bonilha, Leonardo, Gleichgerrcht, Ezequiel, Focke, Niels K, Domin, Martin, von Podewills, Felix, Langner, Soenke, Rummel, Christian, Wiest, Roland, Martin, Pascal, Kotikalapudi, Raviteja, O’Brien, Terence J, Sinclair, Benjamin, Vivash, Lucy, Desmond, Patricia M, Alhusaini, Saud, Doherty, Colin P, Cavalleri, Gianpiero L, Delanty, Norman, Kälviäinen, Reetta, Jackson, Graeme D, Kowalczyk, Magdalena, Mascalchi, Mario, Semmelroch, Mira, Thomas, Rhys H, Soltanian-Zadeh, Hamid, Davoodi-Bojd, Esmaeil, Zhang, Junsong, Lenge, Matteo, Guerrini, Renzo, Bartolini, Emanuele, Hamandi, Khalid, Foley, Sonya, Weber, Bernd, Depondt, Chantal, Absil, Julie, Carr, Sarah JA, Abela, Eugenio, Richardson, Mark P, Devinsky, Orrin, Severino, Mariasavina, Striano, Pasquale, Tortora, Domenico, Hatton, Sean N, Vos, Sjoerd B, Duncan, John S, Whelan, Christopher D, Thompson, Paul M, Sisodiya, Sanjay M, Bernasconi, Andrea, Labate, Angelo, McDonald, Carrie R, Bernasconi, Neda, and Bernhardt, Boris C
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Mental Health ,Brain Disorders ,Epilepsy ,Clinical Research ,Neurosciences ,Neurodegenerative ,Aetiology ,2.1 Biological and endogenous factors ,Neurological - Abstract
Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.
- Published
- 2020
26. Prevalence and prognosis of seizures among patients undergoing mechanical thrombectomy for acute ischemic stroke: A look at pre-2015 aha/asa guidelines update regarding endovascular treatment
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Lekoubou, Alain, Colon, Yael Pinero, Bishu, Kinfe G., Ngonde, Ajah T., Bonilha, Leonardo, and Ovbiagele, Bruce
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- 2023
- Full Text
- View/download PDF
27. The effect of responsive neurostimulation (RNS) on neuropsychiatric and psychosocial outcomes in drug-resistant epilepsy
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Tager, Dale, Panjeti-Moore, Deepa, Yang, Jimmy C., Rivera-Cruz, Angelica, Loring, David W., Staikova, Ekaterina, Block, Cady, Bullinger, Katie L., Rodriguez-Ruiz, Andres A., Cabaniss, Brian T., Winkel, Daniel, Bonilha, Leonardo, Willie, Jon T., Gross, Robert E., Drane, Daniel L., and Karakis, Ioannis
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- 2023
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28. Temporal lobe regions essential for preserved picture naming after left temporal epilepsy surgery
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Binder, Jeffrey R, Tong, Jia‐Qing, Pillay, Sara B, Conant, Lisa L, Humphries, Colin J, Raghavan, Manoj, Mueller, Wade M, Busch, Robyn M, Allen, Linda, Gross, William L, Anderson, Christopher T, Carlson, Chad E, Lowe, Mark J, Langfitt, John T, Tivarus, Madalina E, Drane, Daniel L, Loring, David W, Jacobs, Monica, Morgan, Victoria L, Allendorfer, Jane B, Szaflarski, Jerzy P, Bonilha, Leonardo, Bookheimer, Susan, Grabowski, Thomas, Vannest, Jennifer, Swanson, Sara J, and study, fMRI in Anterior Temporal Epilepsy Surgery
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Epilepsy ,Patient Safety ,Neurodegenerative ,Brain Disorders ,Neurosciences ,2.1 Biological and endogenous factors ,Aetiology ,Neurological ,Adult ,Anomia ,Anterior Temporal Lobectomy ,Brain Mapping ,Drug Resistant Epilepsy ,Epilepsy ,Temporal Lobe ,Female ,Functional Neuroimaging ,Hippocampus ,Humans ,Language Tests ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Postoperative Complications ,Temporal Lobe ,Young Adult ,anomia ,epilepsy ,fusiform gyrus ,lesion localization ,temporal lobe ,fMRI in Anterior Temporal Epilepsy Surgery (FATES) study ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
ObjectiveTo define left temporal lobe regions where surgical resection produces a persistent postoperative decline in naming visual objects.MethodsPre- and postoperative brain magnetic resonance imaging data and picture naming (Boston Naming Test) scores were obtained prospectively from 59 people with drug-resistant left temporal lobe epilepsy. All patients had left hemisphere language dominance at baseline and underwent surgical resection or ablation in the left temporal lobe. Postoperative naming assessment occurred approximately 7 months after surgery. Surgical lesions were mapped to a standard template, and the relationship between presence or absence of a lesion and the degree of naming decline was tested at each template voxel while controlling for effects of overall lesion size.ResultsPatients declined by an average of 15% in their naming score, with wide variation across individuals. Decline was significantly related to damage in a cluster of voxels in the ventral temporal lobe, located mainly in the fusiform gyrus approximately 4-6 cm posterior to the temporal tip. Extent of damage to this region explained roughly 50% of the variance in outcome. Picture naming decline was not related to hippocampal or temporal pole damage.SignificanceThe results provide the first statistical map relating lesion location in left temporal lobe epilepsy surgery to picture naming decline, and they support previous observations of transient naming deficits from electrical stimulation in the basal temporal cortex. The critical lesion is relatively posterior and could be avoided in many patients undergoing left temporal lobe surgery for intractable epilepsy.
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- 2020
29. White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study
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Hatton, Sean N, Huynh, Khoa H, Bonilha, Leonardo, Abela, Eugenio, Alhusaini, Saud, Altmann, Andre, Alvim, Marina KM, Balachandra, Akshara R, Bartolini, Emanuele, Bender, Benjamin, Bernasconi, Neda, Bernasconi, Andrea, Bernhardt, Boris, Bargallo, Núria, Caldairou, Benoit, Caligiuri, Maria E, Carr, Sarah JA, Cavalleri, Gianpiero L, Cendes, Fernando, Concha, Luis, Davoodi-bojd, Esmaeil, Desmond, Patricia M, Devinsky, Orrin, Doherty, Colin P, Domin, Martin, Duncan, John S, Focke, Niels K, Foley, Sonya F, Gambardella, Antonio, Gleichgerrcht, Ezequiel, Guerrini, Renzo, Hamandi, Khalid, Ishikawa, Akari, Keller, Simon S, Kochunov, Peter V, Kotikalapudi, Raviteja, Kreilkamp, Barbara AK, Kwan, Patrick, Labate, Angelo, Langner, Soenke, Lenge, Matteo, Liu, Min, Lui, Elaine, Martin, Pascal, Mascalchi, Mario, Moreira, José CV, Morita-Sherman, Marcia E, O’Brien, Terence J, Pardoe, Heath R, Pariente, José C, Ribeiro, Letícia F, Richardson, Mark P, Rocha, Cristiane S, Rodríguez-Cruces, Raúl, Rosenow, Felix, Severino, Mariasavina, Sinclair, Benjamin, Soltanian-Zadeh, Hamid, Striano, Pasquale, Taylor, Peter N, Thomas, Rhys H, Tortora, Domenico, Velakoulis, Dennis, Vezzani, Annamaria, Vivash, Lucy, von Podewils, Felix, Vos, Sjoerd B, Weber, Bernd, Winston, Gavin P, Yasuda, Clarissa L, Zhu, Alyssa H, Thompson, Paul M, Whelan, Christopher D, Jahanshad, Neda, Sisodiya, Sanjay M, and McDonald, Carrie R
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Genetics ,Neurodegenerative ,Epilepsy ,Clinical Research ,Brain Disorders ,Neurosciences ,Biomedical Imaging ,Aetiology ,2.1 Biological and endogenous factors ,Neurological ,Adult ,Brain ,Diffusion Magnetic Resonance Imaging ,Epileptic Syndromes ,Female ,Humans ,Image Interpretation ,Computer-Assisted ,Male ,Middle Aged ,White Matter ,epilepsy ,diffusion tensor imaging ,multisite analysis ,white matter ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery - Abstract
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analysed from 1069 healthy controls and 1249 patients: temporal lobe epilepsy with hippocampal sclerosis (n = 599), temporal lobe epilepsy with normal MRI (n = 275), genetic generalized epilepsy (n = 182) and non-lesional extratemporal epilepsy (n = 193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fibre tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at P
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- 2020
30. The white matter connectome as an individualized biomarker of language impairment in temporal lobe epilepsy
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Kaestner, Erik, Balachandra, Akshara R, Bahrami, Naeim, Reyes, Anny, Lalani, Sanam J, Macari, Anna Christina, Voets, Natalie L, Drane, Daniel L, Paul, Brianna M, Bonilha, Leonardo, and McDonald, Carrie R
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Biological Psychology ,Clinical and Health Psychology ,Psychology ,Neurodegenerative ,Epilepsy ,Clinical Research ,Neurosciences ,Behavioral and Social Science ,Brain Disorders ,Basic Behavioral and Social Science ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Brain ,Connectome ,Epilepsy ,Temporal Lobe ,Female ,Humans ,Image Interpretation ,Computer-Assisted ,Language Disorders ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Models ,Neurological ,Neural Pathways ,White Matter ,Biological psychology ,Clinical and health psychology - Abstract
ObjectiveThe distributed white matter network underlying language leads to difficulties in extracting clinically meaningful summaries of neural alterations leading to language impairment. Here we determine the predictive ability of the structural connectome (SC), compared with global measures of white matter tract microstructure and clinical data, to discriminate language impaired patients with temporal lobe epilepsy (TLE) from TLE patients without language impairment.MethodsT1- and diffusion-MRI, clinical variables (CVs), and neuropsychological measures of naming and verbal fluency were available for 82 TLE patients. Prediction of language impairment was performed using a robust tree-based classifier (XGBoost) for three models: (1) a CV-model which included demographic and epilepsy-related clinical features, (2) an atlas-based tract-model, including four frontotemporal white matter association tracts implicated in language (i.e., the bilateral arcuate fasciculus, inferior frontal occipital fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus), and (3) a SC-model based on diffusion MRI. For the association tracts, mean fractional anisotropy was calculated as a measure of white matter microstructure for each tract using a diffusion tensor atlas (i.e., AtlasTrack). The SC-model used measurement of cortical-cortical connections arising from a temporal lobe subnetwork derived using probabilistic tractography. Dimensionality reduction of the SC was performed with principal components analysis (PCA). Each model was trained on 49 patients from one epilepsy center and tested on 33 patients from a different center (i.e., an independent dataset). Randomization was performed to test the stability of the results.ResultsThe SC-model yielded a greater area under the curve (AUC; .73) and accuracy (79%) compared to both the tract-model (AUC: .54, p
- Published
- 2020
31. Long-range fibre damage in small vessel brain disease affects aphasia severity
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Wilmskoetter, Janina, Marebwa, Barbara, Basilakos, Alexandra, Fridriksson, Julius, Rorden, Chris, Stark, Brielle C, Johnson, Lisa, Hickok, Gregory, Hillis, Argye E, and Bonilha, Leonardo
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Biological Psychology ,Psychology ,Aphasia ,Stroke ,Aging ,Neurosciences ,Brain Disorders ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Aged ,Brain ,Brain Diseases ,Cerebral Ventricles ,Connectome ,Female ,Humans ,Leukoaraiosis ,Leukoencephalopathies ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Nerve Fibers ,White Matter ,white matter ,brain connectomics ,stroke ,aphasia ,magnetic resonance imaging ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Neurology & Neurosurgery ,Biomedical and clinical sciences ,Health sciences - Abstract
We sought to determine the underlying pathophysiology relating white matter hyperintensities to chronic aphasia severity. We hypothesized that: (i) white matter hyperintensities are associated with damage to fibres of any length, but to a higher percentage of long-range compared to mid- and short-range intracerebral white matter fibres; and (ii) the number of long-range fibres mediates the relationship between white matter hyperintensities and chronic post-stroke aphasia severity. We measured the severity of periventricular and deep white matter hyperintensities and calculated the number and percentages of short-, mid- and long-range white matter fibres in 48 individuals with chronic post-stroke aphasia. Correlation and mediation analyses were performed to assess the relationship between white matter hyperintensities, connectome fibre-length measures and aphasia severity as measured with the aphasia quotient of the Western Aphasia Battery-Revised (WAB-AQ). We found that more severe periventricular and deep white matter hyperintensities correlated with a lower proportion of long-range fibres (r = -0.423, P = 0.003 and r = -0.315, P = 0.029, respectively), counterbalanced by a higher proportion of short-range fibres (r = 0.427, P = 0.002 and r = 0.285, P = 0.050, respectively). More severe periventricular white matter hyperintensities also correlated with a lower proportion of mid-range fibres (r = -0.334, P = 0.020), while deep white matter hyperintensities did not correlate with mid-range fibres (r = -0.169, P = 0.250). Mediation analyses revealed: (i) a significant total effect of periventricular white matter hyperintensities on WAB-AQ (standardized beta = -0.348, P = 0.008); (ii) a non-significant direct effect of periventricular white matter hyperintensities on WAB-AQ (P > 0.05); (iii) significant indirect effects of more severe periventricular white matter hyperintensities on worse aphasia severity mediated in parallel by fewer long-range fibres (effect = -6.23, bootstrapping: standard error = 2.64, 95%CI: -11.82 to -1.56) and more short-range fibres (effect = 4.50, bootstrapping: standard error = 2.59, 95%CI: 0.16 to 10.29). We conclude that small vessel brain disease seems to affect chronic aphasia severity through a change of the proportions of long- and short-range fibres. This observation provides insight into the pathophysiology of small vessel brain disease, and its relationship with brain health and chronic aphasia severity.
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- 2019
32. Neural processing critical for distinguishing between speech sounds
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Kim, Kevin, Adams, Luke, Keator, Lynsey M, Sheppard, Shannon M, Breining, Bonnie L, Rorden, Chris, Fridriksson, Julius, Bonilha, Leonardo, Rogalsky, Corianne, Love, Tracy, Hickok, Gregory, and Hillis, Argye E
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Biological Psychology ,Cognitive and Computational Psychology ,Psychology ,Clinical Research ,Behavioral and Social Science ,Brain Disorders ,Stroke ,Neurosciences ,2.1 Biological and endogenous factors ,Aetiology ,Brain ,Case-Control Studies ,Comprehension ,Female ,Humans ,Male ,Middle Aged ,Parietal Lobe ,Phonetics ,Speech Perception ,Temporal Lobe ,Phoneme discrimination ,Acute ischemic stroke ,Auditory processing ,Lesion-deficit mapping ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Language ,Communication and Culture ,Experimental Psychology ,Biomedical and clinical sciences ,Language ,communication and culture - Abstract
We aimed to identify neural regions where ischemia acutely after stroke is associated with impairment in phoneme discrimination, and to determine whether such deficits are associated with impairment of spoken word comprehension. We evaluated 33 patients within 48 h of left hemisphere ischemic stroke onset with tests of phoneme discrimination and word-picture matching. We identified Pearson correlations between accuracy in phoneme discrimination and accuracy of word comprehension and identified areas where the percentage of infarcted tissue was associated with severity of phoneme discrimination deficit. We found that 54% had deficits in phoneme discrimination relative to healthy controls. Accuracy in phoneme discrimination correlated with accuracy on word comprehension tests. Damage to left intraparietal sulcus and hypoperfusion and/or infarct of left superior temporal gyrus were associated with phoneme discrimination deficits acutely, although patients with these lesions showed improvement or resolution of the deficit by six months.
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- 2019
33. Brain health imaging markers, post-stroke aphasia and Cognition: A scoping review
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Hannan, Jade, Wilmskoetter, Janina, Fridriksson, Julius, Hillis, Argye E., Bonilha, Leonardo, and Busby, Natalie
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- 2023
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34. Under pressure: the interplay of hypertension and white matter hyperintensities with cognition in chronic stroke aphasia
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Hannan, Jade, primary, Busby, Natalie, additional, Roth, Rebecca, additional, Wilmskoetter, Janina, additional, Newman-Norlund, Roger, additional, Rorden, Chris, additional, Bonilha, Leonardo, additional, and Fridriksson, Julius, additional
- Published
- 2024
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35. Utility of intracranial EEG networks depends on re-referencing and connectivity choice
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Shi, Haoer, primary, Pattnaik, Akash R, additional, Aguila, Carlos, additional, Lucas, Alfredo, additional, Sinha, Nishant, additional, Prager, Brian, additional, Mojena, Marissa, additional, Gallagher, Ryan, additional, Parashos, Alexandra, additional, Bonilha, Leonardo, additional, Gleichgerrcht, Ezequiel, additional, Davis, Kathryn A, additional, Litt, Brian, additional, and Conrad, Erin C, additional
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- 2024
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36. Neural network bases of thematic semantic processing in language production
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Schwen Blackett, Deena, Varkey, Jesse, Wilmskoetter, Janina, Roth, Rebecca, Andrews, Keeghan, Busby, Natalie, Gleichgerrcht, Ezequiel, Desai, Rutvik H., Riccardi, Nicholas, Basilakos, Alexandra, Johnson, Lorelei P., Kristinsson, Sigfus, Johnson, Lisa, Rorden, Chris, Spell, Leigh A., Fridriksson, Julius, and Bonilha, Leonardo
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- 2022
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37. Predictors beyond the lesion: Health and demographic factors associated with aphasia severity
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Johnson, Lisa, Nemati, Samaneh, Bonilha, Leonardo, Rorden, Chris, Busby, Natalie, Basilakos, Alexandra, Newman-Norlund, Roger, Hillis, Argye E., Hickok, Gregory, and Fridriksson, Julius
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- 2022
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38. Neural correlates of impaired vocal feedback control in post-stroke aphasia
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Behroozmand, Roozbeh, Bonilha, Leonardo, Rorden, Chris, Hickok, Gregory, and Fridriksson, Julius
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- 2022
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39. Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke
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Seo, Na Jin, Ramakrishnan, Viswanathan, Woodbury, Michelle L., Bonilha, Leonardo, Finetto, Christian, Schranz, Christian, Scronce, Gabrielle, Coupland, Kristen, Blaschke, Jenna, Baker, Adam, Howard, Keith, Meinzer, Caitlyn, Velozo, Craig A., and Adams, Robert J.
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- 2022
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40. Disconnectomics to unravel the network underlying deficits of spatial exploration and attention
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Wiesen, Daniel, Bonilha, Leonardo, Rorden, Christopher, and Karnath, Hans-Otto
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- 2022
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41. High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy
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Gleichgerrcht, Ezequiel, Keller, Simon S., Bryant, Lorna, Moss, Hunter, Kellermann, Tanja S., Biswas, Shubhabrata, Marson, Anthony G., Wilmskoetter, Janina, Jensen, Jens H., and Bonilha, Leonardo
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- 2022
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42. Right hemispheric white matter hyperintensities improve the prediction of spatial neglect severity in acute stroke
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Röhrig, Lisa, Sperber, Christoph, Bonilha, Leonardo, Rorden, Christopher, and Karnath, Hans-Otto
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- 2022
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43. Age-Related Hearing Loss, Cognitive Decline, and Social Interaction: Testing a Framework.
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Arjmandi, Meisam K., Neils-Strunjas, Jean, Nemati, Samaneh, Fridriksson, Julius, Newman-Norlund, Sarah, Newman-Norlund, Roger, and Bonilha, Leonardo
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CROSS-sectional method ,NOISE ,RESEARCH funding ,QUESTIONNAIRES ,AUDIOMETRY ,DESCRIPTIVE statistics ,PRESBYCUSIS ,LONGITUDINAL method ,COGNITION disorders ,INTERPERSONAL relations ,SPEECH perception ,CONFIDENCE intervals ,DATA analysis software ,SOCIAL isolation - Abstract
Purpose: Aging increases risk for hearing loss, cognitive decline, and social isolation; however, the nature of their interconnection remains unclear. This study examined the interplay between age-related hearing loss, cognitive decline, and social isolation in adults by testing the ability to understand speech in background noise, a challenge frequently reported by many older adults. Method: We analyzed data collected from 128 adults (20-79 years of age, Mage = 51 years) recruited as part of the Aging Brain Cohort at the University of South Carolina repository. The participants underwent testing for hearing, cognition, and social interaction, which included pure-tone audiometry, a words-in-noise (WIN) test, a hearing questionnaire (Speech, Spatial and Qualities of Hearing Scale [SSQ12]), a social questionnaire (Patient-Reported Outcomes Measurement Information System-57 Social), and the Montreal Cognitive Assessment. We used a single pure-tone average (PTA) threshold value and a single WIN threshold value for each participant because there were no differences on average between the left and right ears. Results: Poorer hearing was significantly associated with cognitive decline, through both PTA and WIN thresholds, with a stronger association observed for WIN threshold. Adults with poorer hearing also exhibited greater social isolation, as evidenced by their WIN threshold and SSQ12 score, although not through PTA. This connection was more pronounced with the WIN threshold than with the SSQ12 score. Cognition was not related to social isolation, suggesting that social isolation is affected more by the ability to understand words in noise than by cognition in a nondemented population. Conclusions: Understanding speech in challenging auditory environments rather than mere threshold detection is strongly linked to social isolation and cognitive decline. Thus, inclusion of a word-recognition-in-noise test and a social isolation survey in clinical settings is warranted. [ABSTRACT FROM AUTHOR]
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- 2024
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44. Long-range white matter fibres and post-stroke verbal and non-verbal cognition.
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Roth, Rebecca W, Blackett, Deena Schwen, Gleichgerrcht, Ezequiel, Wilmskoetter, Janina, Rorden, Chris, Newman-Norlund, Roger, Sen, Souvik, Fridriksson, Julius, Busby, Natalie, and Bonilha, Leonardo
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- 2024
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45. Impact of white matter networks on risk for memory decline following resection versus ablation in temporal lobe epilepsy.
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Kaestner, Erik, Stasenko, Alena, Schadler, Adam, Roth, Rebecca, Hewitt, Kelsey, Reyes, Anny, Deqiang Qiu, Bonilha, Leonardo, Voets, Natalie, Ranliang Hu, Willie, Jon, Pedersen, Nigel, Shih, Jerry, Ben-Haim, Sharona, Gross, Robert, Drane, Daniel, and McDonald, Carrie R.
- Subjects
TEMPORAL lobectomy ,TEMPORAL lobe epilepsy ,WHITE matter (Nerve tissue) ,MILD cognitive impairment ,VERBAL memory ,HIPPOCAMPAL sclerosis ,TEMPORAL lobe ,MEMORY - Published
- 2024
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46. Brain-Derived Neurotrophic Factor Genotype-Specific Differences in Cortical Activation in Chronic Aphasia
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Kristinsson, Sigfus, Yourganov, Grigori, Xiao, Feifei, Bonilha, Leonardo, Stark, Brielle C., Rorden, Chris, Basilakos, Alexandra, and Fridriksson, Julius
- Abstract
Purpose: The brain-derived neurotrophic factor (BDNF) gene has been shown to be important for synaptic plasticity in animal models. Human research has suggested that BDNF genotype may influence stroke recovery. Some studies have suggested a genotype-specific motor-related brain activation in stroke recovery. However, recovery from aphasia in relation to BDNF genotype and language-related brain activation has received limited attention. We aimed to explore functional brain activation by BDNF genotype in individuals with chronic aphasia. Consistent with findings in healthy individuals and individuals with poststroke motor impairment, we hypothesized that, among individuals with aphasia, the presence of the Met allele of the BDNF gene is associated with reduced functional brain activation compared to noncarriers of the Met allele. Method: Eighty-seven individuals with chronic stroke-induced aphasia performed a naming task during functional magnetic resonance imaging scanning and submitted blood or saliva samples for BDNF genotyping. The mean number of activated voxels was compared between groups, and group-based activation maps were directly compared. Neuropsychological testing was conducted to compare language impairment between BDNF genotype groups. The Western Aphasia Battery Aphasia Quotient (Kertesz, 2007) was included as a covariate in all analyses. Results: While lesion size was comparable between groups, the amount of activation, quantified as the number of activated voxels, was significantly greater in noncarriers of the Met allele (whole brain: 98,500 vs. 28,630, p < 0.001; left hemisphere only: 37,209 vs. 7,000, p < 0.001; right hemisphere only: 74,830 vs. 30,630, p < 0.001). This difference was most strongly expressed in the right hemisphere posterior temporal area, pre- and postcentral gyrus, and frontal lobe, extending into the white matter. Correspondingly, the atypical BDNF genotype group was found to have significantly less severe aphasia (Western Aphasia Battery Aphasia Quotient of 64.2 vs. 54.3, p = 0.033) and performed better on a naming task (Philadelphia Naming Test [Roach, Schwartz, Martin, Grewal, & Brecher, 1996] score of 74.7 vs. 52.8, p = 0.047). A region of interest analysis of intensity of activation revealed no group differences, and a direct comparison of average activation maps across groups similarly yielded null results. Conclusion: BDNF genotype mediates cortical brain activation in individuals with chronic aphasia. Correspondingly, individuals carrying the Met allele present with more severe aphasia compared to noncarriers. These findings warrant further study into the effects of BDNF genotype in aphasia.
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- 2019
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47. The role of disrupted structural connectivity in aphasia
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Roth, Rebecca, primary, Wilmskoetter, Janina, additional, and Bonilha, Leonardo, additional
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- 2022
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48. Connectome-Based Lesion-Symptom Mapping Using Structural Brain Imaging
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Gleichgerrcht, Ezequiel, primary, Wilmskoetter, Janina, additional, and Bonilha, Leonardo, additional
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- 2022
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49. Speech Entrainment for Aphasia Recovery (SpARc) phase II trial design
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Cassarly, Christy, Doyle, Anna, Ly, Trinh, Horn, Janet, Aitchison, Mary, Elm, Jordan, Fridriksson, Julius, and Bonilha, Leonardo
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- 2021
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50. ACUTE SEIZURES AFTER INTRACEREBRAL HEMORRHAGE IN YOUNG INDIVIDUALS: 11-YEAR TRENDS AND ASSOCIATION WITH MORTALITY.
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Lekoubou, Alain, primary, Cohrs, Austin, additional, Dejuk, Mariana, additional, Hong, Jinpyo, additional, Sen, Souvik, additional, Bonilha, Leonardo, additional, and Chinchilli, Vernon M, additional
- Published
- 2024
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