164 results on '"Bonifacino, Aylin C."'
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2. Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
3. Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
4. Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model
5. NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease
6. BCL11A enhancer-edited hematopoietic stem cells persist in rhesus monkeys without toxicity
7. Fetal hemoglobin and F-cell variance in mobilized CD34+ cell-transplanted rhesus monkeys
8. Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study
9. Pre-existing immunity does not impair the engraftment of electroporation-mediated RNP CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation
10. Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study
11. Development of a forward-oriented therapeutic lentiviral vector for hemoglobin disorders
12. Forced enhancer-promoter rewiring to alter gene expression in animal models
13. CD117 Antibody Drug Conjugate-Based Conditioning Allows for Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model
14. Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures
15. Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor
16. Intracoronary infusion of autologous mononuclear cells from bone marrow or granulocyte colony-stimulating factor-mobilized apheresis product may not improve remodelling, contractile function, perfusion, or infarct size in a swine model of large myocardial infarction
17. Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector
18. A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates
19. Durable and Robust Fetal Globin Induction without Anemia in Rhesus Monkeys Following Autologous Hematopoietic Stem Cell Transplant with BCL11A Erythroid Enhancer Editing
20. Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model
21. Intrabone transplantation of CD34+cells with optimized delivery does not enhance engraftment in a rhesus macaque model
22. Bone Marrow as a Hematopoietic Stem Cell Source for Gene Therapy in Sickle Cell Disease: Evidence from Rhesus and SCD Patients
23. HSC Clonal Dynamics after T-Cell Depletion in a Nonhuman Primate Model of Lentiviral Gene Therapy
24. Development of a New Generation, Forward-Oriented Therapeutic Vector for Hemoglobin Disorders
25. Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model
26. Prostaglandin E2 enhances engraftment of human cord blood stem cells and shows long-term safety in preclinical non-human primate transplant models
27. 294. Myeloablative Conditioning Is Required for Efficient Engraftment of Gene-Modified Cells and Prevention of Antibody Production Against Transgene Products in a Rhesus Stem Cell Gene Therapy Model
28. Evaluation of CD4+ Cell Recovery in Vivo Using Single Photon Emission Tomography (SPECT) in Real Time Following CD34+ Cell Transplantation in Rhesus Macaques
29. Optimization of the Spectra Optia for Leukapheresis of Very Small Subjects
30. CD34+CXCR4(CD184)+ Cells Differentiate Into Myeloid Dendritic Cell Progenitors
31. Discordance Between Peripheral Blood and Tissue CD4+ Lymphocyte Reconstitution In Rhesus Monkeys Following Autologous Hematopoietic CD34+ Cell Transplantation: An In Vivo imaging Study
32. Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34+ Cells Correlates With In Vivo Vector Copy Number
33. High-efficiency Transduction of Rhesus Hematopoietic Repopulating Cells by a Modified HIV1-based Lentiviral Vector
34. Significant mobilization of both conventional and regulatory T cells with AMD3100
35. High Transgene Expression Rates After Extended Follow up Among Rhesus Macaque Recipients of Autologous Hematopoietic Stem Cells Transduced with a Modified HIV1-Based Lentiviral Vector
36. Evaluation of Human and Rhesus CD34+CXCR4+ and CD34+CXCR4- Subpopulations
37. TRIM5α Variation Affects Lentiviral Transduction Efficiency for Long-Term Hematopoietic Repopulating Cells in a Rhesus Stem Cell Transplantation Model
38. The Microarray Signature of Rhesus Macaque CD34+CD123 (IL-3 Receptor)+ Hematopoietic Stem/Progenitor Cells Isolated Following Mobilization with Plerixafor Alone or in Combination with Granulocyte Colony-Stimulating Factor (G-CSF)
39. Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models
40. High-Throughput, Sensitive Quantification of Repopulating Hematopoietic Stem Cell Clones
41. Global Gene Expression Signatures in CD34+ Hematopoietic Cells Following Exposure to 16,16-Dimethylprostaglandin E2.
42. Leukocyte Integrin CD18 Expression Mediates Transient Neutropenia Following G-CSF Administration.
43. A Modified HIV1-Based Lentiviral Vector Can Transduce Rhesus Hematopoietic Repopulating Cells as Efficiently as An SIV Vector in An Autologous Transplantation Model.
44. Development of a Human Immunodeficiency Virus Type 1-Based Lentiviral Vector That Allows Efficient Transduction of both Human and Rhesus Blood Cells
45. Development of An HIV1-Based Lentiviral Vector Able to Transduce Both Human and Rhesus Blood Cells.
46. AMD3100 and Granulocyte Colony Stimulating Factor (G-CSF) Mobilize Different CD34+ Cell Populations Based on Global Gene and Micro RNA Expression.
47. Paradoxical drop in circulating neutrophil count following granulocyte-colony stimulating factor and stem cell factor administration in rhesus macaques
48. Retroviral Transduction and Engraftment Ability of Primate Hematopoietic Progenitor and Stem Cells Transduced Under Serum-Free versus Serum-Containing Conditions
49. Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+cell populations based on global gene and microRNA expression signatures
50. Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models
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