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5 results on '"Bongaerts, F"'

1. Detection of distant metastases in esophageal cancer with F-18-FDG PET

Author

Heeren, PAM, Jager, PL, Bongaerts, F, van Dullemen, H, Sluiter, W, Plukker, JTM, Faculteit Medische Wetenschappen/UMCG, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
POSITRON-EMISSION-TOMOGRAPHY, GASTROESOPHAGEAL JUNCTION, CARCINOMA, upstaging, F-18-FDG PET, esophageal cancer
Abstract

Standard staging of esophageal and gastroesophageal junction (GEJ) tumors substantially lacks accuracy. The aim of this study was to investigate whether the addition of PET with F-18-FDG is a valuable gain in the initial staging. Methods: Between January 1996 and January 2002, F-18-FDG PET was performed in 74 patients. Conventional staging included CT in all patients and well-performed endoscopic ultrasonography (EUS) in 52 patients. They were compared with F-18-FDG PET with pathology and follow-up of suspicious lesions as the gold standard. Results: PET identified 70 primary tumors (sensitivity, 95%). Sensitivity to identify locoregional metastases was highest for EUS (69%) but was not different for CT and PET (44% and 55%, respectively). PET was able to identify distant nodal disease in 71% (17/24 patients) compared with 29% (7/24 patients) after combined CT/EUS alone (P = 0.021). Sensitivity to detect distant nodal and systemic (M1) disease increased with PET (78% vs. 37%; P = 0.012). PET upstaged 15 patients (15/74; 20%) correctly as M1 disease, missed by CT/EUS, and correctly downstaged 4 patients (5%) from M1 to MO disease. However, false upstaging and downstaging was encountered in 5 (7%) and 3 (4%) patients, respectively. Conclusion: PET improves the currently applied staging of esophageal and GEJ tumors, particularly by ameliorating the detection of M1 disease.

Published
2004

5. Detection of distant metastases in esophageal cancer with (18)F-FDG PET.

Author

Heeren PA, Jager PL, Bongaerts F, van Dullemen H, Sluiter W, and Plukker JT

Subjects
Adenocarcinoma diagnosis, Adult, Aged, Carcinoma, Squamous Cell diagnosis, Esophageal Neoplasms diagnosis, Female, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging methods, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Adenocarcinoma diagnostic imaging, Adenocarcinoma secondary, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell secondary, Esophageal Neoplasms diagnostic imaging, Fluorodeoxyglucose F18, Tomography, Emission-Computed methods
Abstract

Unlabelled: Standard staging of esophageal and gastroesophageal junction (GEJ) tumors substantially lacks accuracy. The aim of this study was to investigate whether the addition of PET with (18)F-FDG is a valuable gain in the initial staging., Methods: Between January 1996 and January 2002, (18)F-FDG PET was performed in 74 patients. Conventional staging included CT in all patients and well-performed endoscopic ultrasonography (EUS) in 52 patients. They were compared with (18)F-FDG PET with pathology and follow-up of suspicious lesions as the gold standard., Results: PET identified 70 primary tumors (sensitivity, 95%). Sensitivity to identify locoregional metastases was highest for EUS (69%) but was not different for CT and PET (44% and 55%, respectively). PET was able to identify distant nodal disease in 71% (17/24 patients) compared with 29% (7/24 patients) after combined CT/EUS alone (P = 0.021). Sensitivity to detect distant nodal and systemic (M1) disease increased with PET (78% vs. 37%; P = 0.012). PET upstaged 15 patients (15/74; 20%) correctly as M1 disease, missed by CT/EUS, and correctly downstaged 4 patients (5%) from M1 to M0 disease. However, false upstaging and downstaging was encountered in 5 (7%) and 3 (4%) patients, respectively., Conclusion: PET improves the currently applied staging of esophageal and GEJ tumors, particularly by ameliorating the detection of M1 disease.

Published
2004

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