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1. Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

Author

Bongaarts, Anika, Mijnsbergen, Caroline, Anink, Jasper J., Jansen, Floor E., Spliet, Wim G. M., den Dunnen, Wilfred F. A., Coras, Roland, Blümcke, Ingmar, Paulus, Werner, Gruber, Victoria E., Scholl, Theresa, Hainfellner, Johannes A., Feucht, Martha, Kotulska, Katarzyna, Jozwiak, Sergiusz, Grajkowska, Wieslawa, Buccoliero, Anna Maria, Caporalini, Chiara, Giordano, Flavio, Genitori, Lorenzo, Söylemezoğlu, Figen, Pimentel, José, Jones, David T. W., Scicluna, Brendon P., Schouten-van Meeteren, Antoinette Y. N., Mühlebner, Angelika, Mills, James D., and Aronica, Eleonora

Published
2022
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3. Author Correction: Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment

Author

Mills, James D., Iyer, Anand M., van Scheppingen, Jackelien, Bongaarts, Anika, Anink, Jasper J., Janssen, Bart, Zimmer, Till S., Spliet, Wim G., van Rijen, Peter C., Jansen, Floor E., Feucht, Martha, Hainfellner, Johannes A., Krsek, Pavel, Zamecnik, Josef, Kotulska, Katarzyna, Jozwiak, Sergiusz, Jansen, Anna, Lagae, Lieven, Curatolo, Paolo, Kwiatkowski, David J., Pasterkamp, R. Jeroen, Senthilkumar, Ketharini, von Oerthel, Lars, Hoekman, Marco F., Gorter, Jan A., Crino, Peter B., Mühlebner, Angelika, Scicluna, Brendon P., and Aronica, Eleonora

Published
2022
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4. Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Author

Korotkov, Anatoly, Luinenburg, Mark J., Romagnolo, Alessia, Zimmer, Till S., van Scheppingen, Jackelien, Bongaarts, Anika, Broekaart, Diede W. M., Anink, Jasper J., Mijnsbergen, Caroline, Jansen, Floor E., van Hecke, Wim, Spliet, Wim G., van Rijen, Peter C., Feucht, Martha, Hainfellner, Johannes A., Krsek, Pavel, Zamecnik, Josef, Crino, Peter B., Kotulska, Katarzyna, Lagae, Lieven, Jansen, Anna C., Kwiatkowski, David J., Jozwiak, Sergiusz, Curatolo, Paolo, Mühlebner, Angelika, van Vliet, Erwin A., Mills, James D., and Aronica, Eleonora

Published
2022
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5. Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile

Author

Giannikou, Krinio, Zhu, Zachary, Kim, Jaegil, Winden, Kellen D., Tyburczy, Magdalena E., Marron, David, Parker, Joel S., Hebert, Zachary, Bongaarts, Anika, Taing, Len, Long, Henry W., Pisano, William V., Alexandrescu, Sanda, Godlewski, Brianna, Nellist, Mark, Kotulska, Katarzyna, Jozwiak, Sergiusz, Roszkowski, Marcin, Mandera, Marek, Thiele, Elizabeth A., Lidov, Hart, Getz, Gad, Devinsky, Orrin, Lawrence, Michael S., Ligon, Keith L., Ellison, David W., Sahin, Mustafa, Aronica, Eleonora, Meredith, David M., and Kwiatkowski, David J.

Published
2021
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6. The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects

Author

Broekaart, Diede W.M., Bertran, Alexandra, Jia, Shaobo, Korotkov, Anatoly, Senkov, Oleg, Bongaarts, Anika, Mills, James D., Anink, Jasper J., Seco, Jesus, Baayen, Johannes C., Idema, Sander, Chabrol, Elodie, Becker, Albert J., Wadman, Wytse J., Tarrago, Teresa, Gorter, Jan A., Aronica, Eleonora, Prades, Roger, Dityatev, Alexander, and van Vliet, Erwin A.

Subjects
Seizures (Medicine) -- Development and progression -- Drug therapy, Enzyme inhibitors -- Patient outcomes, Neuroplasticity -- Health aspects, Health care industry
Abstract

Matrix metalloproteinases (MMPs) are synthesized by neurons and glia and released into the extracellular space, where they act as modulators of neuroplasticity and neuroinflammatory agents. Development of epilepsy (epileptogenesis) is associated with increased expression of MMPs, and therefore, they may represent potential therapeutic drug targets. Using quantitative PCR (qPCR) and immunohistochemistry, we studied the expression of MMPs and their endogenous inhibitors tissue inhibitors of metalloproteinases (TIMPs) in patients with status epilepticus (SE) or temporal lobe epilepsy (TLE) and in a rat TLE model. Furthermore, we tested the MMP2/9 inhibitor IPR-179 in the rapid-kindling rat model and in the intrahippocampal kainic acid mouse model. In both human and experimental epilepsy, MMP and TIMP expression were persistently dysregulated in the hippocampus compared with in controls. IPR-179 treatment reduced seizure severity in the rapid-kindling model and reduced the number of spontaneous seizures in the kainic acid model (during and up to 7 weeks after delivery) without side effects while improving cognitive behavior. Moreover, our data suggest that IPR-179 prevented an MMP2/9-dependent switch-off normally restraining network excitability during the activity period. Since increased MMP expression is a prominent hallmark of the human epileptogenic brain and the MMP inhibitor IPR-179 exhibits antiseizure and antiepileptogenic effects in rodent epilepsy models and attenuates seizure-induced cognitive decline, it deserves further investigation in clinical trials., Introduction Currently, approximately 65 million people worldwide have epilepsy, and temporal lobe epilepsy (TLE) is the most common form in adults (1). Around 30% of patients inadequately respond to the [...]

Published
2021
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8. Author Correction:Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment (Scientific Reports, (2017), 7, 1, (8089), 10.1038/s41598-017-06145-8)

Author

Mills, James D., Iyer, Anand M., van Scheppingen, Jackelien, Bongaarts, Anika, Anink, Jasper J., Janssen, Bart, Zimmer, Till S., Spliet, Wim G., van Rijen, Peter C., Jansen, Floor E., Feucht, Martha, Hainfellner, Johannes A., Krsek, Pavel, Zamecnik, Josef, Kotulska, Katarzyna, Jozwiak, Sergiusz, Jansen, Anna, Lagae, Lieven, Curatolo, Paolo, Kwiatkowski, David J., Pasterkamp, R. Jeroen, Senthilkumar, Ketharini, von Oerthel, Lars, Hoekman, Marco F., Gorter, Jan A., Crino, Peter B., Mühlebner, Angelika, Scicluna, Brendon P., Aronica, Eleonora, Pathology, APH - Aging & Later Life, APH - Mental Health, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Center of Experimental and Molecular Medicine, AII - Infectious diseases, and AII - Inflammatory diseases

Abstract

This Article contains an error in the Acknowledgements section. “This work was supported by European Union’s Seventh Framework Programme (FP7/2007-2013) under the grant agreement no. 602391 (project acronym EPISTOP; A.I., J.v.S., A.M., E.A., F.I., K.K., S.K., A.J., L.L., P.C., D.K.); Epilepsiefonds (WAR 15-05; RJP); European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642881 (ECMED; A.E., J.G.). None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.” should read: “This work was supported by European Union’s Seventh Framework Programme (FP7/2007-2013) under the Grant Agreement no. 602391 (project acronym EPISTOP; A.I., J.v.S., A.M., E.A., F.I., K.K., S.J., A.J., L.L., P.C., D.K.) and partially supported by the Polish Ministerial funds for science (years 2013–2019) for the implementation of international co-financed project (K.K, S.J.); Epilepsiefonds (WAR 15-05; RJP); European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 642881 (ECMED; A.E., J.G.). None of the authors has any conflict of interest to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.”.

Published
2022

10. Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment

Author

Mills, James D., Iyer, Anand M., van Scheppingen, Jackelien, Bongaarts, Anika, Anink, Jasper J., Janssen, Bart, Zimmer, Till S., Spliet, Wim G., van Rijen, Peter C., Jansen, Floor E., Feucht, Martha, Hainfellner, Johannes A., Krsek, Pavel, Zamecnik, Josef, Kotulska, Katarzyna, Jozwiak, Sergiusz, Jansen, Anna, Lagae, Lieven, Curatolo, Paolo, Kwiatkowski, David J., Pasterkamp, R. Jeroen, Senthilkumar, Ketharini, von Oerthel, Lars, Hoekman, Marco F., Gorter, Jan A., Crino, Peter B., Mühlebner, Angelika, Scicluna, Brendon P., and Aronica, Eleonora

Published
2017
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11. Additional file 2 of Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period

Author

Korotkov, Anatoly, Luinenburg, Mark J., Romagnolo, Alessia, Zimmer, Till S., van Scheppingen, Jackelien, Bongaarts, Anika, Broekaart, Diede W. M., Anink, Jasper J., Mijnsbergen, Caroline, Jansen, Floor E., van Hecke, Wim, Spliet, Wim G., van Rijen, Peter C., Feucht, Martha, Hainfellner, Johannes A., Krsek, Pavel, Zamecnik, Josef, Crino, Peter B., Kotulska, Katarzyna, Lagae, Lieven, Jansen, Anna C., Kwiatkowski, David J., Jozwiak, Sergiusz, Curatolo, Paolo, M��hlebner, Angelika, van Vliet, Erwin A., Mills, James D., and Aronica, Eleonora

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2022
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12. High frequency oscillations associate with neuroinflammation in low-grade epilepsy associated tumors

Author

Sun, Dongqing, primary, van Klink, Nicole E.C., additional, Bongaarts, Anika, additional, Zweiphenning, Willemiek E.J.M., additional, van 't Klooster, Maryse A, additional, Gebbink, Tineke A, additional, Snijders, Tom J, additional, van Eijsden, Pieter, additional, Robe, Pierre A.J.T., additional, Aronica, Eleonora, additional, and Zijlmans, Maeike, additional

Published
2022
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13. Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

Author

Bongaarts, Anika, primary, Mijnsbergen, Caroline, additional, Anink, Jasper J., additional, Jansen, Floor E., additional, Spliet, Wim G. M., additional, den Dunnen, Wilfred F. A., additional, Coras, Roland, additional, Blümcke, Ingmar, additional, Paulus, Werner, additional, Gruber, Victoria E., additional, Scholl, Theresa, additional, Hainfellner, Johannes A., additional, Feucht, Martha, additional, Kotulska, Katarzyna, additional, Jozwiak, Sergiusz, additional, Grajkowska, Wieslawa, additional, Buccoliero, Anna Maria, additional, Caporalini, Chiara, additional, Giordano, Flavio, additional, Genitori, Lorenzo, additional, Söylemezoğlu, Figen, additional, Pimentel, José, additional, Jones, David T. W., additional, Scicluna, Brendon P., additional, Schouten-van Meeteren, Antoinette Y. N., additional, Mühlebner, Angelika, additional, Mills, James D., additional, and Aronica, Eleonora, additional

Published
2021
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14. Impaired myelin production due to an intrinsic failure of oligodendrocytes in mTORpathies

Author

Gruber, Victoria‐Elisabeth, primary, Lang, Judith, additional, Endmayr, Verena, additional, Diehm, Robert, additional, Pimpel, Birgit, additional, Glatter, Sarah, additional, Anink, Jasper J., additional, Bongaarts, Anika, additional, Luinenburg, Mark J., additional, Reinten, Roy J., additional, Wel, Nicole, additional, Larsen, Per, additional, Hainfellner, Johannes A., additional, Rössler, Karl, additional, Aronica, Eleonora, additional, Scholl, Theresa, additional, Mühlebner, Angelika, additional, and Feucht, Martha, additional

Published
2021
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15. Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment.

Author

Mills, James D., Iyer, Anand M., van Scheppingen, Jackelien, Bongaarts, Anika, Anink, Jasper J., Janssen, Bart, Zimmer, Till S., Spliet, Wim G., van Rijen, Peter C., Jansen, Floor E., Feucht, Martha, Hainfellner, Johannes A., Krsek, Pavel, Zamecnik, Josef, Kotulska, Katarzyna, Jozwiak, Sergiusz, Jansen, Anna, Lagae, Lieven, Curatolo, Paolo, and Kwiatkowski, David J.

Subjects
TUBEROUS sclerosis, COMPUTATIONAL complexity, NON-coding RNA, PATHOLOGICAL physiology, AUTOPSY, TUBERS, RNA sequencing, GLUTAMATE receptors
Abstract

Tuberous Sclerosis Complex (TSC) is a rare genetic disorder that results from a mutation in the TSC1 or TSC2 genes leading to constitutive activation of the mechanistic target of rapamycin complex 1 (mTORC1). TSC is associated with autism, intellectual disability and severe epilepsy. Cortical tubers are believed to represent the neuropathological substrates of these disabling manifestations in TSC. In the presented study we used high-throughput RNA sequencing in combination with systems-based computational approaches to investigate the complexity of the TSC molecular network. Overall we detected 438 differentially expressed genes and 991 differentially expressed small non-coding RNAs in cortical tubers compared to autopsy control brain tissue. We observed increased expression of genes associated with inflammatory, innate and adaptive immune responses. In contrast, we observed a down-regulation of genes associated with neurogenesis and glutamate receptor signaling. MicroRNAs represented the largest class of over-expressed small non-coding RNA species in tubers. In particular, our analysis revealed that the miR-34 family (including miR-34a, miR-34b and miR-34c) was significantly over-expressed. Functional studies demonstrated the ability of miR-34b to modulate neurite outgrowth in mouse primary hippocampal neuronal cultures. This study provides new insights into the TSC transcriptomic network along with the identification of potential new treatment targets. [ABSTRACT FROM AUTHOR]

Published
2022
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17. MicroRNA‐34a activation in tuberous sclerosis complex during early brain development may lead to impaired corticogenesis

Author

Korotkov, Anatoly, primary, Sim, Nam Suk, additional, Luinenburg, Mark J., additional, Anink, Jasper J., additional, van Scheppingen, Jackelien, additional, Zimmer, Till S., additional, Bongaarts, Anika, additional, Broekaart, Diede W. M., additional, Mijnsbergen, Caroline, additional, Jansen, Floor E., additional, Van Hecke, Wim, additional, Spliet, Wim G. M., additional, van Rijen, Peter C., additional, Feucht, Martha, additional, Hainfellner, Johannes A., additional, Kršek, Pavel, additional, Zamecnik, Josef, additional, Crino, Peter B., additional, Kotulska, Katarzyna, additional, Lagae, Lieven, additional, Jansen, Anna C., additional, Kwiatkowski, David J., additional, Jozwiak, Sergiusz, additional, Curatolo, Paolo, additional, Mühlebner, Angelika, additional, Lee, Jeong H., additional, Mills, James D., additional, van Vliet, Erwin A., additional, and Aronica, Eleonora, additional

Published
2021
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18. Myelin Pathology Beyond White Matter in Tuberous Sclerosis Complex (TSC) Cortical Tubers

Author

Mühlebner, Angelika, primary, van Scheppingen, Jackelien, additional, de Neef, Andrew, additional, Bongaarts, Anika, additional, Zimmer, Till S, additional, Mills, James D, additional, Jansen, Floor E, additional, Spliet, Wim G M, additional, Krsek, Pavel, additional, Zamecnik, Josef, additional, Coras, Roland, additional, Blumcke, Ingmar, additional, Feucht, Martha, additional, Scholl, Theresa, additional, Gruber, Victoria-Elisabeth, additional, Hainfellner, Johannes A, additional, Söylemezoğlu, Figen, additional, Kotulska, Katarzyna, additional, Lagae, Lieven, additional, Jansen, Anna C, additional, Kwiatkowski, David J, additional, Jozwiak, Sergiusz, additional, Curatolo, Paolo, additional, and Aronica, Eleonora, additional

Published
2020
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19. Dysregulation of the MMP/TIMP Proteolytic System in Subependymal Giant Cell Astrocytomas in Patients With Tuberous Sclerosis Complex: Modulation of MMP by MicroRNA-320d In Vitro

Author

Bongaarts, Anika, primary, de Jong, Jody M, primary, Broekaart, Diede W M, primary, van Scheppingen, Jackelien, primary, Anink, Jasper J, primary, Mijnsbergen, Caroline, primary, Jansen, Floor E, primary, Spliet, Wim G M, primary, den Dunnen, Wilfred F A, primary, Gruber, Victoria E, primary, Scholl, Theresa, primary, Hainfellner, Johannes A, primary, Feucht, Martha, primary, Borkowska, Julita, primary, Kotulska, Katarzyna, primary, Jozwiak, Sergiusz, primary, Grajkowska, Wieslawa, primary, Buccoliero, Anna Maria, primary, Caporalini, Chiara, primary, Giordano, Flavio, primary, Genitori, Lorenzo, primary, Scicluna, Brendon P, primary, Schouten-van Meeteren, Antoinette Y N, primary, van Vliet, Erwin A, primary, Mühlebner, Angelika, primary, Mills, James D, primary, and Aronica, Eleonora, primary

Published
2020
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20. The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas

Author

Bongaarts, Anika, primary, van Scheppingen, Jackelien, additional, Korotkov, Anatoly, additional, Mijnsbergen, Caroline, additional, Anink, Jasper J, additional, Jansen, Floor E, additional, Spliet, Wim G M, additional, den Dunnen, Wilfred F A, additional, Gruber, Victoria E, additional, Scholl, Theresa, additional, Samueli, Sharon, additional, Hainfellner, Johannes A, additional, Feucht, Martha, additional, Kotulska, Katarzyna, additional, Jozwiak, Sergiusz, additional, Grajkowska, Wieslawa, additional, Buccoliero, Anna Maria, additional, Caporalini, Chiara, additional, Giordano, Flavio, additional, Genitori, Lorenzo, additional, Coras, Roland, additional, Blümcke, Ingmar, additional, Krsek, Pavel, additional, Zamecnik, Josef, additional, Meijer, Lisethe, additional, Scicluna, Brendon P, additional, Schouten-van Meeteren, Antoinette Y N, additional, Mühlebner, Angelika, additional, Mills, James D, additional, and Aronica, Eleonora, additional

Published
2019
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21. The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas.

Author

Bongaarts, Anika, Scheppingen, Jackelien van, Korotkov, Anatoly, Mijnsbergen, Caroline, Anink, Jasper J, Jansen, Floor E, Spliet, Wim G M, Dunnen, Wilfred F A den, Gruber, Victoria E, Scholl, Theresa, Samueli, Sharon, Hainfellner, Johannes A, Feucht, Martha, Kotulska, Katarzyna, Jozwiak, Sergiusz, Grajkowska, Wieslawa, Buccoliero, Anna Maria, Caporalini, Chiara, Giordano, Flavio, and Genitori, Lorenzo

Subjects
*ASTROCYTOMAS, *MITOGEN-activated protein kinases, *TUBEROUS sclerosis, *SURGICAL excision, *NEUROCUTANEOUS disorders
Abstract

Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited neurocutaneous disorder caused by inactivating mutations in TSC1 or TSC2 , key regulators of the mechanistic target of rapamycin complex 1 (mTORC1) pathway. In the CNS, TSC is characterized by cortical tubers, subependymal nodules and subependymal giant cell astrocytomas (SEGAs). SEGAs may lead to impaired circulation of CSF resulting in hydrocephalus and raised intracranial pressure in patients with TSC. Currently, surgical resection and mTORC1 inhibitors are the recommended treatment options for patients with SEGA. In the present study, high-throughput RNA-sequencing (SEGAs n = 19, periventricular control n = 8) was used in combination with computational approaches to unravel the complexity of SEGA development. We identified 9400 mRNAs and 94 microRNAs differentially expressed in SEGAs compared to control tissue. The SEGA transcriptome profile was enriched for the mitogen-activated protein kinase (MAPK) pathway, a major regulator of cell proliferation and survival. Analysis at the protein level confirmed that extracellular signal-regulated kinase (ERK) is activated in SEGAs. Subsequently, the inhibition of ERK independently of mTORC1 blockade decreased efficiently the proliferation of primary patient-derived SEGA cultures. Furthermore, we found that LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 were overexpressed at both gene and protein levels in SEGA compared to control tissue. Taken together LAMTOR1–5 can form a complex, known as the 'Ragulator' complex, which is known to activate both mTORC1 and MAPK/ERK pathways. Overall, this study shows that the MAPK/ERK pathway could be used as a target for treatment independent of, or in combination with mTORC1 inhibitors for TSC patients. Moreover, our study provides initial evidence of a possible link between the constitutive activated mTORC1 pathway and a secondary driver pathway of tumour growth. [ABSTRACT FROM AUTHOR]

Published
2020
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22. MicroRNA519d and microRNA4758 can identify gangliogliomas from dysembryoplastic neuroepithelial tumours and astrocytomas

Author

Bongaarts, Anika, primary, Prabowo, Avanita S., additional, Arena, Andrea, additional, Anink, Jasper J., additional, Reinten, Roy J., additional, Jansen, Floor E., additional, Spliet, Wim G.M., additional, Thom, Maria, additional, Coras, Roland, additional, Blümcke, Ingmar, additional, Kotulska, Katarzyna, additional, Jozwiak, Sergiusz, additional, Grajkowska, Wieslawa, additional, Söylemezoğlu, Figen, additional, Pimentel, José, additional, Schouten-van Meeteren, Antoinette Y.N., additional, Mills, James D., additional, Iyer, Anand M., additional, van Vliet, Erwin A., additional, Mühlebner, Angelika, additional, and Aronica, Eleonora, additional

Published
2018
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23. miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes

Author

van Scheppingen, Jackelien, primary, Mills, James D., additional, Zimmer, Till S., additional, Broekaart, Diede W.M., additional, Iori, Valentina, additional, Bongaarts, Anika, additional, Anink, Jasper J., additional, Iyer, Anand M., additional, Korotkov, Anatoly, additional, Jansen, Floor E., additional, van Hecke, Wim, additional, Spliet, Wim G., additional, van Rijen, Peter C., additional, Baayen, Johannes C., additional, Vezzani, Annamaria, additional, van Vliet, Erwin A., additional, and Aronica, Eleonora, additional

Published
2018
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24. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?

Author

Thom, Maria, primary, Liu, Joan, additional, Bongaarts, Anika, additional, Reinten, Roy J., additional, Paradiso, Beatrice, additional, Jäger, Hans Rolf, additional, Reeves, Cheryl, additional, Somani, Alyma, additional, An, Shu, additional, Marsdon, Derek, additional, McEvoy, Andrew, additional, Miserocchi, Anna, additional, Thorne, Lewis, additional, Newman, Fay, additional, Bucur, Sorin, additional, Honavar, Mrinalini, additional, Jacques, Tom, additional, and Aronica, Eleonora, additional

Published
2017
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25. Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations

Author

Bongaarts, Anika, primary, Giannikou, Krinio, additional, Reinten, Roy J., additional, Anink, Jasper J., additional, Mills, James D., additional, Jansen, Floor E., additional, Spliet, Wim G.M., additional, den Dunnen, Willfred F.A., additional, Coras, Roland, additional, Blümcke, Ingmar, additional, Paulus, Werner, additional, Scholl, Theresa, additional, Feucht, Martha, additional, Kotulska, Katarzyna, additional, Jozwiak, Sergiusz, additional, Buccoliero, Anna Maria, additional, Caporalini, Chiara, additional, Giordano, Flavio, additional, Genitori, Lorenzo, additional, Söylemezoğlu, Figen, additional, Pimentel, José, additional, Nellist, Mark, additional, Schouten-van Meeteren, Antoinette Y.N., additional, Nag, Anwesha, additional, Mühlebner, Angelika, additional, Kwiatkowski, David J., additional, and Aronica, Eleonora, additional

Published
2017
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