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3. Genome‐wide association studies of response and side effects to the BNT162b2 vaccine in Italian healthcare workers: Increased antibody levels and side effects in carriers of the HLA‐A*03:01 allele

Author

Magri, Chiara, primary, Marchina, Eleonora, additional, Sansone, Emanuele, additional, D'Adamo, Adamo Pio, additional, Cappellani, Stefania, additional, Bonfanti, Carlo, additional, Terlenghi, Luigina, additional, Biasiotto, Giorgio, additional, Zanella, Isabella, additional, Sala, Emma, additional, Caruso, Arnaldo, additional, Lombardo, Massimo, additional, Gasparini, Paolo, additional, De Palma, Giuseppe, additional, and Gennarelli, Massimo, additional

Published
2023
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7. The Effect of the Immunization Schedule and Antibody Levels (Anti-S) on the Risk of SARS-CoV-2 Infection in a Large Cohort of Healthcare Workers in Northern Italy

Author

Sansone, Emanuele, primary, Collatuzzo, Giulia, additional, Renzetti, Stefano, additional, Ditano, Giorgia, additional, Bonfanti, Carlo, additional, Sala, Emma, additional, Terlenghi, Luigina, additional, Matteelli, Alberto, additional, Abedini, Mahsa, additional, Asafo, Shuffield Seyram, additional, Boffetta, Paolo, additional, and De Palma, Giuseppe, additional

Published
2023
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10. Immune Responses to SARS-CoV-2 Infection and Vaccine in a Big Italian COVID-19 Hospital: An 18-Month Follow-Up

Author

Sansone, Emanuele, primary, Bonfanti, Carlo, additional, Sala, Emma, additional, Renzetti, Stefano, additional, Terlenghi, Luigina, additional, Matteelli, Alberto, additional, Tiraboschi, Mara Maria, additional, Pedrazzi, Tatiana, additional, Lombardo, Massimo, additional, Rossi, Camillo, additional, Indelicato, Anna Maria, additional, Caruso, Arnaldo, additional, and De Palma, Giuseppe, additional

Published
2022
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13. SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers

Author

Porru, Stefano, primary, Monaco, Maria Grazia Lourdes, additional, Spiteri, Gianluca, additional, Carta, Angela, additional, Pezzani, Maria Diletta, additional, Lippi, Giuseppe, additional, Gibellini, Davide, additional, Tacconelli, Evelina, additional, Dalla Vecchia, Ilaria, additional, Sala, Emma, additional, Sansone, Emanuele, additional, De Palma, Giuseppe, additional, Bonfanti, Carlo, additional, Lombardo, Massimo, additional, Terlenghi, Luigina, additional, Pira, Enrico, additional, Mansour, Ihab, additional, Coggiola, Maurizio, additional, Ciocan, Catalina, additional, Godono, Alessandro, additional, Tardon, Adonina, additional, Rodriguez-Suarez, Marta-Maria, additional, Fernandez-Tardon, Guillermo, additional, Jimeno-Demuth, Francisco-Jose, additional, Castro-Delgado, Rafael-Vicente, additional, Iglesias Cabo, Tania, additional, Scapellato, Maria Luisa, additional, Liviero, Filippo, additional, Moretto, Angelo, additional, Mason, Paola, additional, Pavanello, Sofia, additional, Volpin, Anna, additional, Vimercati, Luigi, additional, Tafuri, Silvio, additional, De Maria, Luigi, additional, Sponselli, Stefania, additional, Stefanizzi, Pasquale, additional, Caputi, Antonio, additional, Gobba, Fabriziomaria, additional, Modenese, Alberto, additional, Casolari, Loretta, additional, Garavini, Denise, additional, D’Elia, Cristiana, additional, Mariani, Stefania, additional, Filon, Francesca Larese, additional, Cegolon, Luca, additional, Negro, Corrado, additional, Ronchese, Federico, additional, Rui, Francesca, additional, De Michieli, Paola, additional, Murgia, Nicola, additional, Dell’Omo, Marco, additional, Muzi, Giacomo, additional, Fiordi, Tiziana, additional, Gambelunghe, Angela, additional, Folletti, Ilenia, additional, Mates, Dana, additional, Calota, Violeta Claudia, additional, Neamtu, Andra, additional, Perseca, Ovidiu, additional, Staicu, Catalin Alexandru, additional, Voinoiu, Angelica, additional, Fabiánová, Eleonóra, additional, Bérešová, Jana, additional, Adamčáková, Zora Kľocová, additional, Nedela, Roman, additional, Lesňáková, Anna, additional, Holčíková, Jana, additional, Boffetta, Paolo, additional, Abedini, Mahsa, additional, Ditano, Giorgia, additional, Asafo, Shuffield Seyram, additional, Visci, Giovanni, additional, Violante, Francesco Saverio, additional, Zunarelli, Carlotta, additional, and Verlato, Giuseppe, additional

Published
2022
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18. Traceability of SARS‐CoV‐2 transmission through quasispecies analysis.

Author

Messali, Serena, Rondina, Alessandro, Giovanetti, Marta, Bonfanti, Carlo, Ciccozzi, Massimo, Caruso, Arnaldo, and Caccuri, Francesca

Subjects
SINGLE nucleotide polymorphisms, SARS-CoV-2, COVID-19 pandemic, GENETIC variation, TRACE analysis
Abstract

During COVID‐19 pandemic, consensus genomic sequences were used for rapidly monitor the spread of the virus worldwide. However, less attention was paid to intrahost genetic diversity. In fact, in the infected host, SARS‐CoV‐2 consists in an ensemble of replicating and closely related viral variants so‐called quasispecies. Here we show that intrahost single nucleotide variants (iSNVs) represent a target for contact tracing analysis. Our data indicate that in the acute phase of infection, in highly likely transmission links, the number of viral particles transmitted from one host to another (bottleneck size) is large enough to propagate iSNVs among individuals. Furthermore, we demonstrate that, during SARS‐CoV‐2 outbreaks when the consensus sequences are identical, it is possible to reconstruct the transmission chains by genomic investigations of iSNVs. Specifically, we found that it is possible to identify transmission chains by limiting the analysis of iSNVs to only three well‐conserved genes, namely nsp2, ORF3, and ORF7. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Immune Responses to SARS-CoV-2 Infection and Vaccine in a Big Italian COVID-19 Hospital: An 18-Month Follow-Up.

Author

Sansone, Emanuele, Bonfanti, Carlo, Sala, Emma, Renzetti, Stefano, Terlenghi, Luigina, Matteelli, Alberto, Tiraboschi, Mara Maria, Pedrazzi, Tatiana, Lombardo, Massimo, Rossi, Camillo, Indelicato, Anna Maria, Caruso, Arnaldo, and De Palma, Giuseppe

Subjects
COVID-19 vaccines, IMMUNE response, YOUNG workers, MEDICAL personnel, COVID-19
Abstract

Objectives: This is a longitudinal prospective study which was designed to assess the trend of anti-SARS-CoV-2 antibodies targeting the Spike (anti-S) and Nucleocapside protein (anti-N) viral antigens over a 9-month period after the administration of an anti-SARS-CoV-2 vaccine in a big COVID-19 hospital located in Northern Italy. Participants: 7411 vaccinated workers were included in a linear mixed-effect model analysis performed to model the anti-S decay over the 9 months following the vaccination, during serological screening performed approximately 2, 4, and 9 months following the first jab administration. Serological tests performed in the 9 months preceding vaccine administration were retrospectively analysed to identify the burden of infections occurring before vaccination. Results: The serological assays were used for monitoring the antibody titres during the observational period. Vaccination significantly reduced the rate of infection and elicited a specific humoral response, which lasted during the whole observational period (9 months). A decay was observed in all considered subgroups. At 35 weeks, workers with no history of pre-vaccine infection showed a significantly lower anti-S titre (−2522 U/mL on average (−2589.7 to −2445.7)); younger workers showed significantly higher anti-S titres (140.2 U/mL on average (82.4 to 201.3)). Only seven immunocompromised workers did not show significant levels of anti-S antibodies; three of them, all females, showed a specific T-cell response. Conclusions: Comparing the 9-month periods before and after the first vaccine dose, a significant reduction in infection rate was observed (1708 cases vs. 156). Pre-vaccine infection, especially if contracted during the first pandemic wave, greatly enhanced the response to vaccination, which was significantly affected also by age both in extent and duration (inversely related). A gender effect on the T-cell immune response was observed in a small group of workers who did not produce antibodies after vaccine administration. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Co-infection of chlamydia pneumoniae and mycoplasma pneumoniae with SARS-CoV-2 is associated with more severe features

Author

De Francesco, Maria Antonia, Poiesi, Claudio, Gargiulo, Franco, Bonfanti, Carlo, Pollara, Patrizia, Fiorentini, Simona, Caccuri, Francesca, Carta, Valentina, Mangeri, Lucia, Pellizzeri, Simone, Rizzoni, Damiano, Malerba, Paolo, Salvetti, Massimo, Muiesan, Maria Lorenza, Alberici, Federico, Scolari, Francesco, Pilotto, Andrea, Padovani, Alessandro, Bezzi, Michela, Chiappini, Raffaella, Ricci, Chiara, Castellano, Maurizio, Berlendis, Marialma, Savio, Giulia, Montani, Giovanni, Ronconi, Maurizio, Bove, Sergio, Focà, Emanuele, Tomasoni, Lina, Castelli, Francesco, Rossini, Angelo, Inciardi, Riccardo, Metra, Marco, and Caruso, Arnaldo

Published
2021
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30. Serological Response to SARS-CoV-2 in Health Care Workers Employed in a Large Tertiary Hospital in Lombardy, Northern Italy

Author

Comelli, Agnese, primary, Focà, Emanuele, additional, Sansone, Emanuele, additional, Tomasi, Cesare, additional, Albini, Elisa, additional, Quiros-Roldan, Eugenia, additional, Tomasoni, Lina Rachele, additional, Sala, Emma, additional, Bonfanti, Carlo, additional, Caccuri, Francesca, additional, Caruso, Arnaldo, additional, De Palma, Giuseppe, additional, and Castelli, Francesco, additional

Published
2021
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41. Relationship between pp65 antigenemia levels and real-time quantitative DNA PCR for Human Cytomegalovirus (HCMV) management in immunocompromised patients

Author

Bonfanti Carlo, Perandin Francesca, Valloncini Barbara, Pollara Caterina P, Cariani Elisabetta, and Manca Nino

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Quantitative real-time PCR assays, which are more rapid and practical than pp65 antigenemia determination, are progressively becoming the preferred method for monitoring Human Cytomegalovirus (HCMV) reactivation. However, the relationship between HCMV DNA and antigenemia levels is still under investigation. The aim of this study was to analyse the relationship between HCMV DNA and pp65 antigenemia levels in order to identify clinically useful threshold values for the management of patients. Methods 475 consecutive samples from 156 immunosuppressed patients were tested for HCMV by pp65 antigenemia and Real-time PCR assay. Results 136 out of 475 consecutive samples derived from 48 patients showed evidence of HCMV infection. HCMV DNA was detected in 106 samples, pp65 antigen in 3, and both markers in 27. pp65 antigen detection was associated with higher HCMV DNA levels. The cut-off HCMV DNA level that best predicted pp65 antigenemia in this series of samples was 11,500 copies/ml, but different threshold levels could be observed for specific groups of patients. HCMV disease was observed in 5 out of 48 patients with active HCMV infection. The presence of clinical symptoms was associated with positive pp65 and with higher antigenemia levels. Higher HCMV DNA load at the onset of viral replication was correlated to the development of clinical symptoms. Conclusion Both pp65 antigenemia and HCMV DNA load can be useful for the prospective monitoring of immunocompromised subjects. Specific cut-off levels capable of triggering preemptive antiviral treatment should be determined in accordance to the type of test used and the characteristics of patients and prospectively validated.

Published
2007
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42. Microbiological characterization and effect of resin composites in cervical lesions

Author

Vicente Faus-Matoses, Bonfanti Carlo, Antonio Cerutti, Giorgio Piccinelli, and Nicola Barabanti

Subjects
Abfraction, Class V, Composite, Restoration, S. mutans, Dentistry (all), business.industry, Chemistry, Research, Plaque composition, Resin composite, Dentistry, Plaque growth, Odontología, medicine.disease, Ciencias de la salud, Operative Dentistry and Endodontics, Tooth plaque, In vivo, medicine, CIENCIAS MÃ DICAS [UNESCO], business, General Dentistry
Abstract

Background Non carious cervical lesions associated to muscle hyperfunctions are increasing. Microhybrid resin composites are used to restore cervical abfractions. The purpose of this study was to investigate if resin composites modify tooth plaque, inducing an increment of cariogenic microflora and evaluate their effect, in vivo and in vitro, against S. mutans. Material and Methods Eight abfractions were restored with two microhybrid resin composites (Venus, Heraeus-Kulzer® and Esthet-X, Dentsply®), after gnatological therapy, in three patients with muscle hyperfunctions. For each abfraction three samples of plaque were taken from the cervical perimeter: before the restoration, one week and three months after restoration. The samples were evaluated both by traditional microbiological methods and by Polymerase Chain Reaction (PCR). In vitro, disk-shaped specimens of the two composites were prepared to estimate the effects against pre-cultured S. mutans, after incubation at 37°C for 24h and assessed by a turbidimetric technique. Results In vivo no differences were found in plaque growth, for all samples, before and after restoration with both composites; in vitro, instead, a significant reduction of S. mutans growth was found between specimens of two composites (Mann-Whitney U-test p>0,06). Conclusions In this study a relevant consideration was elicited: composite materials, in vivo, do not modify plaque composition of non carious cervical lesions to a potential cariogenic plaque. Key words:Abfraction, restoration, S. mutans, composite, class V.

Published
2017

44. Additional file 1: of Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infection in adolescents in Northern Italy: an observational school-based study

Author

Matteelli, Alberto, Capelli, Michela, Sulis, Giorgia, Toninelli, Giuseppe, Carvalho, Anna, Pecorelli, Sergio, Caruso, Arnaldo, Bonfanti, Carlo, Gargiulo, Franco, and Donato, Francesco

Abstract

STROBE Statementâ checklist of items that should be included in reports of observational studies. (DOCX 31Â kb)

Published
2016
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46. The evolution of anticoagulant therapy

Author

Franchini, Massimo, Liumbruno, Giancarlo M., Bonfanti, Carlo, and Lippi, Giuseppe

Subjects
Vitamin K, Unfractionated heparin, Low molecular weight heparin, Heparin, Administration, Oral, Venous Thromboembolism, Review, History, 20th Century, History, 21st Century, Vitamin K antagonists, New oral anticoagulants, Humans, Warfarin, Factor Xa Inhibitors
Abstract

Arterial and venous thromboembolism are leading causes of morbidity and mortality around the world. For almost 70 years, heparins (unfractionated heparin and low molecular weight heparins) and vitamin K antagonists have been the leading therapeutic medical options for the treatment and prevention of thromboembolic disorders. Nevertheless, the many limitations of these traditional anticoagulants have fuelled the search for novel agents over the past 15 years, and a new class of oral anticoagulants that specifically target activated factor X and thrombin has been developed and is now commercially available. In this narrative review, the evolution of anticoagulant therapy is summarised, with a focus on newer oral anticoagulants.

Published
2015

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