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Ectopic locations of parathyroid adenomas are a rare condition and can cause difficulty in their diagnosis and surgical treatment. We report two cases of intrathyroid parathyroid lesions. In the first patient, preoperative localization studies suggested the possibility of a parathyroid adenoma outside the thyroid gland. When a pathological gland is not found during surgery for primary hyperparathyroidism, an ectopic parathyroid gland was found in the thyroid tissue. In the second patient, in an existing thyroid nodule was found an ectopic normal parathyroid gland postoperatively.

After intravenous infusion of the thromboplastin-35- S-heparin complex into rats, maintained on the atherogenic diet within a prolonged period, distribution of the label in the animal tissues and its clearance were studied; total and non-enzymatic fibrinolytic activities were estimated. Inhibition of functions of the anticoagulation system, caused by long-term atherogenic diet in the animals, led to inhibition of the initial steps of heparin clearance as well as to alteration of the glycosaminoglycan distribution in various tissues. At the same time, formation and accumulation of heparin complexes as well as the non-enzymatic fibrinolytic activity were decreased in some tissues.

The possibility of heparin penetration into brain cells was shown. The penetration occurred apparently in the form of heparin complexes with thromboplastin. The intensity of penetration depended on the functional state of the anticoagulation system. Accumulation of 35S-heparin and of its complex with thromboplastin was distinctly limited in brain tissue of animals with depression of the anticoagulation system followed the long-term maintaining of the animals on an atherogenic diet.