540 results on '"Bonet, Catalina"'
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2. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries: results from the EPIC cohort study
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Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
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- 2023
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3. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort
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Christakoudi, Sofia, Tsilidis, Konstantinos K., Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S., Dahm, Christina C., Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M., Monninkhof, Evelyn M., Quirós, J. Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H., Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K., Aglago, Elom K., Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio
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- 2023
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4. Breast cancer risk for the joint exposure to metals and metalloids in women: Results from the EPIC-Spain cohort
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Fernández-Martínez, Nicolás Francisco, Rodríguez-Barranco, Miguel, Huerta, José María, Gil, Fernando, Olmedo, Pablo, Molina-Montes, Esther, Guevara, Marcela, Zamora-Ros, Raúl, Jiménez-Zabala, Ana, Colorado-Yohar, Sandra Milena, Ardanaz, Eva, Bonet, Catalina, Amiano, Pilar, Chirlaque, María Dolores, Pérez-Gómez, Beatriz, Jiménez-Moleón, José Juan, Martín-Jiménez, Miguel, de Santiago, Esperanza, and Sánchez, María-José
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- 2024
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5. The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study
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Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K., Gunter, Marc J., Kaaks, Rudolf, Schulze, Matthias B., Fortner, Renée T., Antoniussen, Christian S., Dahm, Christina C., Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M., Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M., Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, and Agudo, Antonio
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- 2023
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6. Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study
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Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, and Agudo, Antonio
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- 2023
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7. Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study
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Sedlmeier, Anja M., Viallon, Vivian, Ferrari, Pietro, Peruchet-Noray, Laia, Fontvieille, Emma, Amadou, Amina, Seyed Khoei, Nazlisadat, Weber, Andrea, Baurecht, Hansjörg, Heath, Alicia K., Tsilidis, Kostas, Kaaks, Rudolf, Katzke, Verena, Inan-Eroglu, Elif, Schulze, Matthias B., Overvad, Kim, Bonet, Catalina, Ubago-Guisado, Esther, Chirlaque, María-Dolores, Ardanaz, Eva, Perez-Cornago, Aurora, Pala, Valeria, Tumino, Rosario, Sacerdote, Carlotta, Pasanisi, Fabrizio, Borch, Kristin B., Rylander, Charlotta, Weiderpass, Elisabete, Gunter, Marc J., Fervers, Béatrice, Leitzmann, Michael F., and Freisling, Heinz
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- 2023
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8. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study
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Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula
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- 2022
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9. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
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Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian
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- 2022
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10. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
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Nimptsch, Katharina, Aleksandrova, Krasimira, Fedirko, Veronika, Jenab, Mazda, Gunter, Marc J., Siersema, Peter D., Wu, Kana, Katzke, Verena, Kaaks, Rudolf, Panico, Salvatore, Palli, Domenico, May, Anne M, Sieri, Sabina, Bueno-de-Mesquita, Bas, Standahl, Karina, Sánchez, Maria-Jose, Perez-Cornago, Aurora, Olsen, Anja, Tjønneland, Anne, Bonet, Catalina Bonet, Dahm, Christina C., Chirlaque, María-Dolores, Fiano, Valentina, Tumino, Rosario, Gurrea, Aurelio Barricarte, Boutron-Ruault, Marie-Christine, Menegaux, Florence, Severi, Gianluca, van Guelpen, Bethany, Lee, Young-Ae, and Pischon, Tobias
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- 2022
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11. Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort study
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Kohls, Mirjam, Freisling, Heinz, Charvat, Hadrien, Soerjomataram, Isabelle, Viallon, Vivian, Davila-Batista, Veronica, Kaaks, Rudolf, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B., Dahm, Christina C., Tilma Vistisen, Helene, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Bonet, Catalina, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Masala, Giovanna, Palli, Domenico, Krogh, Vittorio, Ricceri, Fulvio, Rolandsson, Olov, Lu, Sai San Moon, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Gunter, Marc J., Ferrari, Pietro, Berger, Ursula, and Arnold, Melina
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- 2022
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12. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations
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Mandle, Hannah B, primary, Jenab, Mazda, additional, Gunter, Marc J, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Dahm, Christina C, additional, Zhang, Jie, additional, Sugier, Pierre-Emmanuel, additional, Rothwell, Joseph, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena A, additional, Schulze, Matthias B, additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Panico, Salvatore, additional, Sacerdote, Carlotta, additional, Bonet, Catalina, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Huerta, José María, additional, Guevara, Marcela, additional, Palmqvist, Richard, additional, Löwenmark, Thyra, additional, Perez-Cornago, Aurora, additional, Weiderpass, Elisabete, additional, Heath, Alicia K, additional, Cross, Amanda J, additional, Vineis, Paolo, additional, Hughes, David J, additional, and Fedirko, Veronika, additional
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- 2024
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13. A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study
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Sobiecki, Jakub G., Imamura, Fumiaki, Davis, Courtney R., Sharp, Stephen J., Koulman, Albert, Hodgson, Jonathan M., Guevara, Marcela, Schulze, Matthias B., Zheng, Ju-Sheng, Agnoli, Claudia, Bonet, Catalina, Colorado-Yohar, Sandra M., Fagherazzi, Guy, Franks, Paul W., Gundersen, Thomas E., Jannasch, Franziska, Kaaks, Rudolf, Katzke, Verena, Molina-Montes, Esther, Nilsson, Peter M., Palli, Domenico, Panico, Salvatore, Papier, Keren, Rolandsson, Olov, Sacerdote, Carlotta, Tjønneland, Anne, Tong, Tammy Y. N., van der Schouw, Yvonne T., Danesh, John, Butterworth, Adam S., Riboli, Elio, Murphy, Karen J., Wareham, Nicholas J., and Forouhi, Nita G.
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Type 2 diabetes -- Diagnosis -- Care and treatment ,Biological markers -- Analysis ,Biological sciences - Abstract
Background Self-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured biomarker of the Mediterranean diet. Methods and findings We derived a biomarker score based on 5 circulating carotenoids and 24 fatty acids that discriminated between the Mediterranean or habitual diet arms of a parallel design, 6-month partial-feeding randomised controlled trial (RCT) conducted between 2013 and 2014, the MedLey trial (128 participants out of 166 randomised). We applied this biomarker score in an observational study, the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, to assess the association of the score with T2D incidence over an average of 9.7 years of follow-up since the baseline (1991 to 1998). We included 22,202 participants, of whom 9,453 were T2D cases, with relevant biomarkers from an original case-cohort of 27,779 participants sampled from a cohort of 340,234 people. As a secondary measure of the Mediterranean diet, we used a score estimated from dietary-self report. Within the trial, the biomarker score discriminated well between the 2 arms; the cross-validated C-statistic was 0.88 (95% confidence interval (CI) 0.82 to 0.94). The score was inversely associated with incident T2D in EPIC-InterAct: the hazard ratio (HR) per standard deviation of the score was 0.71 (95% CI: 0.65 to 0.77) following adjustment for sociodemographic, lifestyle and medical factors, and adiposity. In comparison, the HR per standard deviation of the self-reported Mediterranean diet was 0.90 (95% CI: 0.86 to 0.95). Assuming the score was causally associated with T2D, higher adherence to the Mediterranean diet in Western European adults by 10 percentiles of the score was estimated to reduce the incidence of T2D by 11% (95% CI: 7% to 14%). The study limitations included potential measurement error in nutritional biomarkers, unclear specificity of the biomarker score to the Mediterranean diet, and possible residual confounding. Conclusions These findings suggest that objectively assessed adherence to the Mediterranean diet is associated with lower risk of T2D and that even modestly higher adherence may have the potential to reduce the population burden of T2D meaningfully. Trial registration Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12613000602729 https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=363860., Author(s): Jakub G. Sobiecki 1, Fumiaki Imamura 1, Courtney R. Davis 2, Stephen J. Sharp 1, Albert Koulman 1,3, Jonathan M. Hodgson 4,5, Marcela Guevara 6,7,8, Matthias B. Schulze 9,10,11, [...]
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- 2023
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14. Evaluation of risk prediction models to select lung cancer screening participants in Europe: a prospective cohort consortium analysis
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Feng, Xiaoshuang, Goodley, Patrick, Alcala, Karine, Guida, Florence, Kaaks, Rudolf, Vermeulen, Roel, Downward, George S, Bonet, Catalina, Colorado-Yohar, Sandra M, Albanes, Demetrius, Weinstein, Stephanie J, Goldberg, Marcel, Zins, Marie, Relton, Caroline, Langhammer, Arnulf, Skogholt, Anne Heidi, Johansson, Mattias, and Robbins, Hilary A
- Abstract
Lung cancer risk prediction models might efficiently identify individuals who should be offered lung cancer screening. However, their performance has not been comprehensively evaluated in Europe. We aimed to externally validate and evaluate the performance of several risk prediction models that predict lung cancer incidence or mortality in prospective European cohorts.
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- 2024
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15. On the use of the healthy lifestyle index to investigate specific disease outcomes
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Epi Kanker Team B, Cancer, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Viallon, Vivian, Freisling, Heinz, Matta, Komodo, Nannsen, Anne Østergaard, Dahm, Christina C., Tjønneland, Anne, Eriksen, Anne Kirstine, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Tagliabue, Giovanna, Simeon, Vittorio, Tumino, Rosario, Milani, Lorenzo, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Nøst, Therese Haugdahl, Borch, Kristin Benjaminsen, Sandanger, Torkjel M., Quirós, J. Ramón, Rodriguez-Barranco, Miguel, Bonet, Catalina, Aizpurua-Atxega, Amaia, Cirera, Lluís, Guevara, Marcela, Sundström, Björn, Winkvist, Anna, Heath, Alicia K., Gunter, Marc J., Weiderpass, Elisabete, Johansson, Mattias, Ferrari, Pietro, Epi Kanker Team B, Cancer, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Viallon, Vivian, Freisling, Heinz, Matta, Komodo, Nannsen, Anne Østergaard, Dahm, Christina C., Tjønneland, Anne, Eriksen, Anne Kirstine, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Tagliabue, Giovanna, Simeon, Vittorio, Tumino, Rosario, Milani, Lorenzo, Derksen, Jeroen W.G., van der Schouw, Yvonne T., Nøst, Therese Haugdahl, Borch, Kristin Benjaminsen, Sandanger, Torkjel M., Quirós, J. Ramón, Rodriguez-Barranco, Miguel, Bonet, Catalina, Aizpurua-Atxega, Amaia, Cirera, Lluís, Guevara, Marcela, Sundström, Björn, Winkvist, Anna, Heath, Alicia K., Gunter, Marc J., Weiderpass, Elisabete, Johansson, Mattias, and Ferrari, Pietro
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- 2024
16. Evaluation of risk prediction models to select lung cancer screening participants in Europe: a prospective cohort consortium analysis
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Planetary Health & Exposoom, Cancer, Circulatory Health, Feng, Xiaoshuang, Goodley, Patrick, Alcala, Karine, Guida, Florence, Kaaks, Rudolf, Vermeulen, Roel, Downward, George S, Bonet, Catalina, Colorado-Yohar, Sandra M, Albanes, Demetrius, Weinstein, Stephanie J, Goldberg, Marcel, Zins, Marie, Relton, Caroline, Langhammer, Arnulf, Skogholt, Anne Heidi, Johansson, Mattias, Robbins, Hilary A, Planetary Health & Exposoom, Cancer, Circulatory Health, Feng, Xiaoshuang, Goodley, Patrick, Alcala, Karine, Guida, Florence, Kaaks, Rudolf, Vermeulen, Roel, Downward, George S, Bonet, Catalina, Colorado-Yohar, Sandra M, Albanes, Demetrius, Weinstein, Stephanie J, Goldberg, Marcel, Zins, Marie, Relton, Caroline, Langhammer, Arnulf, Skogholt, Anne Heidi, Johansson, Mattias, and Robbins, Hilary A
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- 2024
17. Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations
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Mandle, Hannah B., Jenab, Mazda, Gunter, Marc J., Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Zhang, Jie, Sugier, Pierre-Emmanuel, Rothwell, Joseph, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Sacerdote, Carlotta, Bonet, Catalina, Sanchez, Maria-Jose, Amiano, Pilar, Huerta, Jose Maria, Guevara, Marcela, Palmqvist, Richard, Löwenmark, Thyra, Perez-Cornago, Aurora, Weiderpass, Elisabete, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Hughes, David J., Fedirko, Veronika, Mandle, Hannah B., Jenab, Mazda, Gunter, Marc J., Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Zhang, Jie, Sugier, Pierre-Emmanuel, Rothwell, Joseph, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Sacerdote, Carlotta, Bonet, Catalina, Sanchez, Maria-Jose, Amiano, Pilar, Huerta, Jose Maria, Guevara, Marcela, Palmqvist, Richard, Löwenmark, Thyra, Perez-Cornago, Aurora, Weiderpass, Elisabete, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Hughes, David J., and Fedirko, Veronika
- Abstract
Gut barrier dysfunction and related inflammation are known to be associated with the development and progression of colorectal cancer (CRC). We investigated associations of 292 single-nucleotide polymorphisms (SNPs) from 27 genes related to endotoxins/lipopolysaccharide (LPS) sensing and tolerance, mucin synthesis, inflammation, and Crohn's disease with colon and rectal cancer risks. Incident CRC cases (N = 1374; colon = 871, rectum = 503) were matched 1:1 to controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. Previously measured serum concentrations of gut barrier function and inflammation biomarkers (flagellin/LPS-specific immunoglobulins and C-reactive protein [CRP]) were available for a sub-set of participants (Ncases = 1001; Ncontrols = 667). Forty-two unique SNPs from 19 different genes were associated with serum biomarkers at Punadjusted <= 0.05 among controls. Among SNPs associated with a gut permeability score, 24 SNPs were in genes related to LPS sensing and mucin synthesis. Nine out of 12 SNPs associated with CRP were in genes related to inflammation or Crohn's disease. TLR4 was associated with colon cancer at the SNP level (nine SNPs, all Punadjusted <= 0.04) and at the gene level (Punadjusted <= 0.01). TLR4 rs10759934 was associated with rectal cancer but not colon cancer. Similarly, IL10 was associated with rectal cancer risk at an SNP and gene level (both Punadjusted <= 0.01), but not colon cancer. Genes and SNPs were selected a priori; therefore, we present unadjusted P-values. However, no association was statistically significant after multiple testing correction. This large and comprehensive study has identified gut barrier function and inflammation-related genes possibly contributing to CRC risk in European populations and is consistent with potential etiological links between host genetic background, gut barrier permeability, microbial endotoxemia, and CRC development.
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- 2024
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18. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort
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Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-de-Mesquita, HB As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quirós, J Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay-Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Hepatitis ,Infectious Diseases ,Hepatitis - B ,Liver Cancer ,Prevention ,Liver Disease ,Cancer ,Chronic Liver Disease and Cirrhosis ,Rare Diseases ,Nutrition ,Digestive Diseases ,Clinical Research ,Emerging Infectious Diseases ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Good Health and Well Being ,Adult ,Aged ,Carcinoma ,Hepatocellular ,Case-Control Studies ,Diet ,Dietary Fats ,Europe ,Feeding Behavior ,Female ,Humans ,Incidence ,Life Style ,Liver Neoplasms ,Male ,Middle Aged ,Nutritional Status ,Prospective Studies ,Risk ,Risk Factors ,Surveys and Questionnaires ,Young Adult ,European populations ,cohort study ,dietary fats ,hepatocellular carcinoma ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
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- 2015
19. Breast cancer risk for the joint exposure to metals and metalloids in women: Results from the EPIC-Spain cohort
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Fernández-Martínez, Nicolás Francisco, primary, Rodríguez-Barranco, Miguel, additional, Huerta, José María, additional, Gil, Fernando, additional, Olmedo, Pablo, additional, Molina-Montes, Esther, additional, Guevara, Marcela, additional, Zamora-Ros, Raúl, additional, Jiménez-Zabala, Ana, additional, Colorado-Yohar, Sandra Milena, additional, Ardanaz, Eva, additional, Bonet, Catalina, additional, Amiano, Pilar, additional, Chirlaque, María Dolores, additional, Pérez-Gómez, Beatriz, additional, Jiménez-Moleón, José Juan, additional, Martín-Jiménez, Miguel, additional, de Santiago, Esperanza, additional, and Sánchez, María José, additional
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- 2023
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20. On the use of the healthy lifestyle index to investigate specific disease outcomes
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Viallon, Vivian, primary, Freisling, Heinz, additional, Matta, Komodo, additional, Dahm, Christina, additional, Tjonneland, Anne, additional, Erisken, Anne Kirstine, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Mattias, additional, Masala, Giovanna, additional, Tagliabue, Giovanna, additional, Simeon, Vittorio, additional, Tumino, Rosario, additional, Milani, Lorenzo, additional, Derksen, Jeroen W.G., additional, Schouw, Yvonne T. van der, additional, Nøst, Therese Haugdahl, additional, Borch, Kristin Benjaminsen, additional, Sandanger, Torkjel, additional, Quiros, J. Ramon, additional, Barranco, Miguel Rodríguez, additional, Bonet, Catalina, additional, Aizpurua-Atxega, Amaia, additional, Cirera, Lluís, additional, Guevara, Marcela, additional, Sundström, Björn, additional, Winkvist, Anna, additional, Heath, Alicia K, additional, Gunter, Marc J., additional, Weiderpass, Elisabete, additional, Johansson, Mattias, additional, Ferrari, Pietro, additional, and Naansen, Østergaard, additional
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- 2023
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21. Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies
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Nimptsch, Katharina, Song, Mingyang, Aleksandrova, Krasimira, Katsoulis, Michail, Freisling, Heinz, Jenab, Mazda, Gunter, Marc J., Tsilidis, Konstantinos K., Weiderpass, Elisabete, Bueno-De-Mesquita, H. Bas, Chong, Dawn Q., Jensen, Majken K., Wu, Chunsen, Overvad, Kim, Kühn, Tilman, Barrdahl, Myrto, Melander, Olle, Jirström, Karin, Peeters, Petra H., Sieri, Sabina, Panico, Salvatore, Cross, Amanda J., Riboli, Elio, Van Guelpen, Bethany, Myte, Robin, Huerta, José María, Rodriguez-Barranco, Miguel, Quirós, José Ramón, Dorronsoro, Miren, Tjønneland, Anne, Olsen, Anja, Travis, Ruth, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Severi, Gianluca, Bonet, Catalina, Palli, Domenico, Janke, Jürgen, Lee, Young-Ae, Boeing, Heiner, Giovannucci, Edward L., Ogino, Shuji, Fuchs, Charles S., Rimm, Eric, Wu, Kana, Chan, Andrew T., and Pischon, Tobias
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- 2017
22. OR25-04-23 Association of Mediterranean Diet With Survival After Breast Cancer Diagnosis Among Women in Nine European Countries
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Castro-Espin, Carlota, primary, Espin, Carlota Castro, additional, Bonet, Catalina, additional, Crous-Bou, Marta, additional, Riboli, Elio, additional, Dossus, Laure, additional, and Agudo, Antonio, additional
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- 2023
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23. OR25-06-23 Dietary Patterns Related to Biological Mechanisms and Survival After Breast Cancer Diagnosis: Results From a Cohort Study
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Castro-Espin, Carlota, primary, Espin, Carlota Castro, additional, Bonet, Catalina, additional, Crous-Bou, Marta, additional, Dossus, Laure, additional, Riboli, Elio, additional, and Agudo, Antonio, additional
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- 2023
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24. Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
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Cai, Lina, Wheeler, Eleanor, Kerrison, Nicola D., Luan, Jian’an, Deloukas, Panos, Franks, Paul W., Amiano, Pilar, Ardanaz, Eva, Bonet, Catalina, Fagherazzi, Guy, Groop, Leif C., Kaaks, Rudolf, Huerta, José María, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Panico, Salvatore, Rodriguez-Barranco, Miguel, Rolandsson, Olov, Sacerdote, Carlotta, Schulze, Matthias B., Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, McCarthy, Mark I., Barroso, Inês, Langenberg, Claudia, and Wareham, Nicholas J.
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- 2020
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25. Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
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Seyed Khoei, Nazlisadat, Jenab, Mazda, Murphy, Neil, Banbury, Barbara L., Carreras-Torres, Robert, Viallon, Vivian, Kühn, Tilman, Bueno-de-Mesquita, Bas, Aleksandrova, Krasimira, Cross, Amanda J., Weiderpass, Elisabete, Stepien, Magdalena, Bulmer, Andrew, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Carbonnel, Franck, Katzke, Verena, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Merino, Susana, Bonet, Catalina, Rodríguez-Barranco, Miguel, Gil, Leire, Chirlaque, Maria-Dolores, Ardanaz, Eva, Myte, Robin, Hultdin, Johan, Perez-Cornago, Aurora, Aune, Dagfinn, Tsilidis, Konstantinos K., Albanes, Demetrius, Baron, John A., Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cotterchio, Michelle, Gallinger, Steven, Gruber, Stephen B., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Li, Huyghe, Jeroen R., Jenkins, Mark A., Joshi, Amit D., Kampman, Ellen, Larsson, Susanna C., Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Martín, Vicente, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Parfrey, Patrick S., Pharoah, Paul D. P., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Thibodeau, Stephen N., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zhang, Xuehong, Ferrari, Pietro, Anton, Gabriele, Peters, Annette, Peters, Ulrike, Gunter, Marc J., Wagner, Karl-Heinz, and Freisling, Heinz
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- 2020
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26. High adherence to Western dietary pattern and prostate cancer risk: findings from the EPIC‐Spain cohort
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Castelló, Adela, primary, Rodríguez‐Barranco, Miguel, additional, Pérez‐Gómez, Beatriz, additional, Chirlaque, Maria Dolores, additional, Bonet, Catalina, additional, Amiano, Pilar, additional, Ardanaz, Eva, additional, Huerta, José María, additional, Zamora‐Ros, Raúl, additional, Quirós, José Ramon, additional, Barricarte‐Gurrea, Aurelio, additional, Pollán, Marina, additional, and Sanchez, María‐José, additional
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- 2023
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27. Supplementary Tables 1-2 from Prediagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations
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Fedirko, Veronika, primary, Riboli, Elio, primary, Tjønneland, Anne, primary, Ferrari, Pietro, primary, Olsen, Anja, primary, Bueno-de-Mesquita, H. Bas, primary, van Duijnhoven, Fränzel J.B., primary, Norat, Teresa, primary, Jansen, Eugène H.J.M., primary, Dahm, Christina C., primary, Overvad, Kim, primary, Boutron-Ruault, Marie-Christine, primary, Clavel-Chapelon, Françoise, primary, Racine, Antoine, primary, Lukanova, Annekatrin, primary, Teucher, Birgit, primary, Boeing, Heiner, primary, Aleksandrova, Krasimira, primary, Trichopoulou, Antonia, primary, Benetou, Vassiliki, primary, Trichopoulos, Dimitrios, primary, Grioni, Sara, primary, Vineis, Paolo, primary, Panico, Salvatore, primary, Palli, Domenico, primary, Tumino, Rosario, primary, Siersema, Peter D., primary, Peeters, Petra H., primary, Skeie, Guri, primary, Brustad, Magritt, primary, Chirlaque, Maria-Dolores, primary, Barricarte, Aurelio, primary, Ramón Quirós, Jose, primary, Sánchez, Maria José, primary, Dorronsoro, Miren, primary, Bonet, Catalina, primary, Palmqvist, Richard, primary, Hallmans, Göran, primary, Key, Timothy J., primary, Crowe, Francesca, primary, Khaw, Kay-Tee, primary, Wareham, Nick, primary, Romieu, Isabelle, primary, McKay, James, primary, Wark, Petra A., primary, Romaguera, Dora, primary, and Jenab, Mazda, primary
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- 2023
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28. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)
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Mahamat-Saleh, Yahya, Al-Rahmoun, Marie, Severi, Gianluca, Ghiasvand, Reza, Veierod, Marit B., Caini, Saverio, Palli, Domenico, Botteri, Edoardo, Sacerdote, Carlotta, Ricceri, Fulvio, Lukic, Marko, Sánchez, Maria J., Pala, Valeria, Tumino, Rosario, Chiodini, Paolo, Amiano, Pilar, Colorado-Yohar, Sandra, Chirlaque, María-Dolores, Ardanaz, Eva, Bonet, Catalina, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Overvad, Kim, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Kyrø, Cecilie, Bueno-de-Mesquita, Bas, Manjer, Jonas, Jansson, Malin, Esberg, Anders, Mori, Nagisa, Ferrari, Pietro, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Kvaskoff, Marina, Mahamat-Saleh, Yahya, Al-Rahmoun, Marie, Severi, Gianluca, Ghiasvand, Reza, Veierod, Marit B., Caini, Saverio, Palli, Domenico, Botteri, Edoardo, Sacerdote, Carlotta, Ricceri, Fulvio, Lukic, Marko, Sánchez, Maria J., Pala, Valeria, Tumino, Rosario, Chiodini, Paolo, Amiano, Pilar, Colorado-Yohar, Sandra, Chirlaque, María-Dolores, Ardanaz, Eva, Bonet, Catalina, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Overvad, Kim, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Kyrø, Cecilie, Bueno-de-Mesquita, Bas, Manjer, Jonas, Jansson, Malin, Esberg, Anders, Mori, Nagisa, Ferrari, Pietro, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, and Kvaskoff, Marina
- Abstract
Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; Ptrend =.001), BCC (HR = 1.12, 95% CI = 1.01-1.23; Ptrend =.04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95-1.44; Ptrend =.17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90-1.30; Ptrend =.13; BCC: HR = 1.08, 95% CI = 1.00-1.17, Ptrend =.03; melanoma: HR = 0.93, 95% CI = 0.80-1.08, Ptrend =.13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08-1.99; Ptrend =.0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04-1.31; Ptrend =.14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11-1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer.
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- 2023
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29. Association of Mediterranean diet with survival after breast cancer diagnosis in women from nine European countries:results from the EPIC cohort study
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Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Nadal-Zaragoza, Núria, Tjønneland, Anne, Mellemkjær, Lene, Hajji-Louati, Mariem, Truong, Thérèse, Katzke, Verena, Le Cornet, Charlotte, Schulze, Matthias B., Jannasch, Franziska, Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Di Girolamo, Chiara, Skeie, Guri, Borch, Kristin Benjaminsen, Olsen, Karina Standahl, Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Sund, Malin, Bodén, Stina, Gunter, Marc J., Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Aguilera-Buenosvinos, Inmaculada, Tsilidis, Kostas K., Heath, Alicia K., Aune, Dagfinn, Dossus, Laure, and Agudo, Antonio
- Abstract
Background The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and, Background: The Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality. Methods: A total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0–5), medium (score 6–8), and high (score 9–16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality. Results: After a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01–1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84–1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87–0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72–0.91). Conclusions: Consuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of m
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- 2023
30. A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes:Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study
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Sobiecki, Jakub G, Imamura, Fumiaki, Davis, Courtney R, Sharp, Stephen J, Koulman, Albert, Hodgson, Jonathan M, Guevara, Marcela, Schulze, Matthias B, Zheng, Ju-Sheng, Agnoli, Claudia, Bonet, Catalina, Colorado-Yohar, Sandra M, Fagherazzi, Guy, Franks, Paul W, Gundersen, Thomas E, Jannasch, Franziska, Kaaks, Rudolf, Katzke, Verena, Molina-Montes, Esther, Nilsson, Peter M, Palli, Domenico, Panico, Salvatore, Papier, Keren, Rolandsson, Olov, Sacerdote, Carlotta, Tjønneland, Anne, Tong, Tammy Y N, van der Schouw, Yvonne T, Danesh, John, Butterworth, Adam S, Riboli, Elio, Murphy, Karen J, Wareham, Nicholas J, Forouhi, Nita G, Sobiecki, Jakub G, Imamura, Fumiaki, Davis, Courtney R, Sharp, Stephen J, Koulman, Albert, Hodgson, Jonathan M, Guevara, Marcela, Schulze, Matthias B, Zheng, Ju-Sheng, Agnoli, Claudia, Bonet, Catalina, Colorado-Yohar, Sandra M, Fagherazzi, Guy, Franks, Paul W, Gundersen, Thomas E, Jannasch, Franziska, Kaaks, Rudolf, Katzke, Verena, Molina-Montes, Esther, Nilsson, Peter M, Palli, Domenico, Panico, Salvatore, Papier, Keren, Rolandsson, Olov, Sacerdote, Carlotta, Tjønneland, Anne, Tong, Tammy Y N, van der Schouw, Yvonne T, Danesh, John, Butterworth, Adam S, Riboli, Elio, Murphy, Karen J, Wareham, Nicholas J, and Forouhi, Nita G
- Abstract
Background Self-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured biomarker of the Mediterranean diet. Methods and findings We derived a biomarker score based on 5 circulating carotenoids and 24 fatty acids that discriminated between the Mediterranean or habitual diet arms of a parallel design, 6-month partial-feeding randomised controlled trial (RCT) conducted between 2013 and 2014, the MedLey trial (128 participants out of 166 randomised). We applied this biomarker score in an observational study, the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, to assess the association of the score with T2D incidence over an average of 9.7 years of follow-up since the baseline (1991 to 1998). We included 22,202 participants, of whom 9,453 were T2D cases, with relevant biomarkers from an original case-cohort of 27,779 participants sampled from a cohort of 340,234 people. As a secondary measure of the Mediterranean diet, we used a score estimated from dietary-self report. Within the trial, the biomarker score discriminated well between the 2 arms; the cross-validated C-statistic was 0.88 (95% confidence interval (CI) 0.82 to 0.94). The score was inversely associated with incident T2D in EPIC-InterAct: the hazard ratio (HR) per standard deviation of the score was 0.71 (95% CI: 0.65 to 0.77) following adjustment for sociodemographic, lifestyle and medical factors, and adiposity. In comparison, the HR per standard deviation of the self-reported Mediterranean diet was 0.90 (95% CI: 0.86 to 0.95). Assuming the score was causally associated with T2D, higher adherence to the Mediterranean diet in Western European adults by 10 percentiles of the score wa, BACKGROUND: Self-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured biomarker of the Mediterranean diet.METHODS AND FINDINGS: We derived a biomarker score based on 5 circulating carotenoids and 24 fatty acids that discriminated between the Mediterranean or habitual diet arms of a parallel design, 6-month partial-feeding randomised controlled trial (RCT) conducted between 2013 and 2014, the MedLey trial (128 participants out of 166 randomised). We applied this biomarker score in an observational study, the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, to assess the association of the score with T2D incidence over an average of 9.7 years of follow-up since the baseline (1991 to 1998). We included 22,202 participants, of whom 9,453 were T2D cases, with relevant biomarkers from an original case-cohort of 27,779 participants sampled from a cohort of 340,234 people. As a secondary measure of the Mediterranean diet, we used a score estimated from dietary-self report. Within the trial, the biomarker score discriminated well between the 2 arms; the cross-validated C-statistic was 0.88 (95% confidence interval (CI) 0.82 to 0.94). The score was inversely associated with incident T2D in EPIC-InterAct: the hazard ratio (HR) per standard deviation of the score was 0.71 (95% CI: 0.65 to 0.77) following adjustment for sociodemographic, lifestyle and medical factors, and adiposity. In comparison, the HR per standard deviation of the self-reported Mediterranean diet was 0.90 (95% CI: 0.86 to 0.95). Assuming the score was causally associated with T2D, higher adherence to the Mediterranean diet in Western European adults by 10 percentiles of the score was esti
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- 2023
31. Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis:results from a cohort study
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Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, Agudo, Antonio, Castro-Espin, Carlota, Bonet, Catalina, Crous-Bou, Marta, Katzke, Verena, Le Cornet, Charlotte, Jannasch, Franziska, Schulze, Matthias B., Olsen, Anja, Tjønneland, Anne, Dahm, Christina C., Antoniussen, Christian S., Sánchez, Maria Jose, Amiano, Pilar, Chirlaque, María Dolores, Guevara, Marcela, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, De Magistris, Maria Santucci, Sund, Malin, Bodén, Stina, Jensen, Torill Enget, Olsen, Karina Standahl, Skeie, Guri, Gunter, Marc J., Rinaldi, Sabina, Gonzalez-Gil, Esther M., Weiderpass, Elisabete, Christakoudi, Sofia, Heath, Alicia K., Dossus, Laure, and Agudo, Antonio
- Abstract
Background Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival. Methods The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality. Results We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1–SD 0.92; 95%CI 0.87–0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1–SD 1.06; 95%CI 1.00–1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality. Conclusions Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors., Background: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival. Methods: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality. Results: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1–SD 0.92; 95%CI 0.87–0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1–SD 1.06; 95%CI 1.00–1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality. Conclusions: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.
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- 2023
32. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort
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Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, Riboli, Elio, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team C, Christakoudi, Sofia, Tsilidis, Konstantinos K, Dossus, Laure, Rinaldi, Sabina, Weiderpass, Elisabete, Antoniussen, Christian S, Dahm, Christina C, Tjønneland, Anne, Mellemkjær, Lene, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B, Masala, Giovanna, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, May, Anne M, Monninkhof, Evelyn M, Quirós, J Ramón, Bonet, Catalina, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Rosendahl, Ann H, Stocks, Tanja, Perez-Cornago, Aurora, Tin Tin, Sandar, Heath, Alicia K, Aglago, Elom K, Peruchet-Noray, Laia, Freisling, Heinz, and Riboli, Elio
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- 2023
33. The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study
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Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K, Gunter, Marc J, Kaaks, Rudolf, Schulze, Matthias B, Fortner, Renée T, Antoniussen, Christian S, Dahm, Christina C, Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M, Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M, Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, Agudo, Antonio, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K, Gunter, Marc J, Kaaks, Rudolf, Schulze, Matthias B, Fortner, Renée T, Antoniussen, Christian S, Dahm, Christina C, Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M, Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M, Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, and Agudo, Antonio
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- 2023
34. A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study
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Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Sobiecki, Jakub G, Imamura, Fumiaki, Davis, Courtney R, Sharp, Stephen J, Koulman, Albert, Hodgson, Jonathan M, Guevara, Marcela, Schulze, Matthias B, Zheng, Ju-Sheng, Agnoli, Claudia, Bonet, Catalina, Colorado-Yohar, Sandra M, Fagherazzi, Guy, Franks, Paul W, Gundersen, Thomas E, Jannasch, Franziska, Kaaks, Rudolf, Katzke, Verena, Molina-Montes, Esther, Nilsson, Peter M, Palli, Domenico, Panico, Salvatore, Papier, Keren, Rolandsson, Olov, Sacerdote, Carlotta, Tjønneland, Anne, Tong, Tammy Y N, van der Schouw, Yvonne T, Danesh, John, Butterworth, Adam S, Riboli, Elio, Murphy, Karen J, Wareham, Nicholas J, Forouhi, Nita G, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Sobiecki, Jakub G, Imamura, Fumiaki, Davis, Courtney R, Sharp, Stephen J, Koulman, Albert, Hodgson, Jonathan M, Guevara, Marcela, Schulze, Matthias B, Zheng, Ju-Sheng, Agnoli, Claudia, Bonet, Catalina, Colorado-Yohar, Sandra M, Fagherazzi, Guy, Franks, Paul W, Gundersen, Thomas E, Jannasch, Franziska, Kaaks, Rudolf, Katzke, Verena, Molina-Montes, Esther, Nilsson, Peter M, Palli, Domenico, Panico, Salvatore, Papier, Keren, Rolandsson, Olov, Sacerdote, Carlotta, Tjønneland, Anne, Tong, Tammy Y N, van der Schouw, Yvonne T, Danesh, John, Butterworth, Adam S, Riboli, Elio, Murphy, Karen J, Wareham, Nicholas J, and Forouhi, Nita G
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- 2023
35. Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study
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Sedlmeier, Anja M., primary, Viallon, Vivian, additional, Ferrari, Pietro, additional, Peruchet-Noray, Laia, additional, Fontvieille, Emma, additional, Amadou, Amina, additional, Seyed Khoei, Nazlisadat, additional, Weber, Andrea, additional, Baurecht, Hansjörg, additional, Heath, Alicia K., additional, Tsilidis, Kostas, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Inan-Eroglu, Elif, additional, Schulze, Matthias B., additional, Overvad, Kim, additional, Bonet, Catalina, additional, Ubago-Guisado, Esther, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Perez-Cornago, Aurora, additional, Pala, Valeria, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Pasanisi, Fabrizio, additional, Borch, Kristin B., additional, Rylander, Charlotta, additional, Weiderpass, Elisabete, additional, Gunter, Marc J., additional, Fervers, Béatrice, additional, Leitzmann, Michael F., additional, and Freisling, Heinz, additional
- Published
- 2022
- Full Text
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36. SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer
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Companioni Nápoles, Osmel, Tsao, Amy C., Sanz-Anquela, José Miguel, Sala, Núria, Bonet, Catalina, Pardo, María Luisa, Ding, Lin, Simo, Ornella, Saqui-Salces, Milena, Blanco, Verónica Parra, Gonzalez, Carlos A., and Merchant, Juanita L.
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- 2017
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37. Non-invasive risk scores for prediction of type 2 diabetes (EPIC-InterAct): a validation of existing models
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Kengne, Andre Pascal, Beulens, Joline WJ, Peelen, Linda M, Moons, Karel GM, van der Schouw, Yvonne T, Schulze, Matthias B, Spijkerman, Annemieke MW, Griffin, Simon J, Grobbee, Diederick E, Palla, Luigi, Tormo, Maria-Jose, Arriola, Larraitz, Barengo, Noël C, Barricarte, Aurelio, Boeing, Heiner, Bonet, Catalina, Clavel-Chapelon, Françoise, Dartois, Laureen, Fagherazzi, Guy, Franks, Paul W, Huerta, José María, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay Tee, Li, Kuanrong, Mühlenbruch, Kristin, Nilsson, Peter M, Overvad, Kim, Overvad, Thure F, Palli, Domenico, Panico, Salvatore, Quirós, J Ramón, Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sánchez, María-José, Slimani, Nadia, Tagliabue, Giovanna, Tjønneland, Anne, Tumino, Rosario, van der A, Daphne L, Forouhi, Nita G, Sharp, Stephen J, Langenberg, Claudia, Riboli, Elio, and Wareham, Nicholas J
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- 2014
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38. Weight change later in life and colon and rectal cancer risk in participants in the EPIC-PANACEA study
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Steins Bisschop, Charlotte N, van Gils, Carla H, Emaus, Marleen J, Bueno-de-Mesquita, H Bas, Monninkhof, Evelyn M, Boeing, Heiner, Aleksandrova, Krasmira, Jenab, Mazda, Norat, Teresa, Riboli, Elio, Boutron-Rualt, Marie-Christine, Fagherazzi, Guy, Racine, Antoine, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Naccarati, Alessio, Mattiello, Amalia, Argüelles, Marcial Vicente, Sanchez, Maria José, Tormo, Maria José, Ardanaz, Eva, Dorronsoro, Miren, Bonet, Catalina, Khaw, Kay-Tee, Key, Tim, Trichopoulou, Antonia, Orfanos, Philippos, Naska, Androniki, Kaaks, Rudolph R, Lukanova, Annekatrin, Pischon, Tobias, Ljuslinder, Ingrid, Jirström, Karin, Ohlsson, Bodil, Overvad, Kim, Landsvig Berentzen, Tina, Halkjaer, Jytte, Tjonneland, Anne, Weiderpass, Elisabete, Skeie, Guri, Braaten, Tonje, Siersema, Peter D, Freisling, Heinz, Ferrari, Pietro, Peeters, Petra HM, and May, Anne M
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- 2014
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39. Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort
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Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael, Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Benjaminsen Borch, Kristin, Oluwafemi Oyeyemi, Sunday, Quirós, Ramón J, Bonet, Catalina, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nicholas, Assi, Nada, Ward, Heather A, Aune, Dagfinn, Riboli, Elio, and Boeing, Heiner
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- 2017
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40. The relationship between blood pressure and risk of renal cell carcinoma
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Alcala, Karine, Mariosa, Daniela, Smith-Byrne, Karl, Nasrollahzadeh Nesheli, Dariush, Carreras-Torres, Robert, Ardanaz Aicua, Eva, Bondonno, Nicola P, Bonet, Catalina, Brunström, Mattias, Bueno-De-Mesquita, Bas, Chirlaque, María-Dolores, Christakoudi, Sofia, Heath, Alicia K, Kaaks, Rudolf, Katzke, Verena, Krogh, Vittorio, Ljungberg, Börje, Martin, Richard M, May, Anne, Melander, Olle, Palli, Domenico, Rodriguez-Barranco, Miguel, Sacerdote, Carlotta, Stocks, Tanja, Tjønneland, Anne, Travis, Ruth C., Vermeulen, Roel, Chanock, Stephen, Purdue, Mark, Weiderpass, Elisabete, Muller, David, Brennan, Paul, Johansson, Mattias, and IRAS OH Epidemiology Chemical Agents
- Subjects
systolic blood pressure ,Mendelian randomization ,diastolic blood pressure ,kidney cancer ,RCC - Abstract
Background: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail. Methods: Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP. Results: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP. Conclusion: The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP. © 2022 World Health Organization,. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.
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- 2022
41. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort ( EPIC )
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Mahamat‐Saleh, Yahya, primary, Al‐Rahmoun, Marie, additional, Severi, Gianluca, additional, Ghiasvand, Reza, additional, Veierod, Marit B., additional, Caini, Saverio, additional, Palli, Domenico, additional, Botteri, Edoardo, additional, Sacerdote, Carlotta, additional, Ricceri, Fulvio, additional, Lukic, Marko, additional, Sánchez, Maria J., additional, Pala, Valeria, additional, Tumino, Rosario, additional, Chiodini, Paolo, additional, Amiano, Pilar, additional, Colorado‐Yohar, Sandra, additional, Chirlaque, María‐Dolores, additional, Ardanaz, Eva, additional, Bonet, Catalina, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Overvad, Kim, additional, Dahm, Christina C., additional, Antoniussen, Christian S., additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Bueno‐de‐Mesquita, Bas, additional, Manjer, Jonas, additional, Jansson, Malin, additional, Esberg, Anders, additional, Mori, Nagisa, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Boutron‐Ruault, Marie‐Christine, additional, and Kvaskoff, Marina, additional
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- 2022
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42. Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Hosnijeh, Fatemeh Saberi, Romieu, Isabelle, Gallo, Valentina, Riboli, Elio, Tjønneland, Anne, Halkjær, Jytte, Fagherazzi, Guy, Clavel-Chapelon, Françoise, Dossus, Laure, Lukanova, Annie, Kaaks, Rudolf, Trichopoulou, Antonia, Lagiou, Pagona, Katsoulis, Michael, Panico, Salvatore, Tagliabue, Giovanna, Bonet, Catalina, Dorronsoro, Miren, Huerta, José María, Ardanaz, Eva, Sánchez, Maria-José, Johansen, Dorthe, Borgquist, Signe, Peeters, Petra, Bueno-de-Mesquita, H. Bas, Ros, Martine M., Travis, Ruth C., Key, Timothy J., Vineis, Paolo, and Vermeulen, Roel
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- 2013
43. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study
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Epi Kanker Team B, Cancer, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, Jakszyn, Paula, Epi Kanker Team B, Cancer, Cayssials, Valerie, Buckland, Genevieve, Crous-Bou, Marta, Bonet, Catalina, Weiderpass, Elisabete, Skie, Guri, Aune, Dagfinn, Heath, Alicia, Nøst, Therese Haugdahl, Masala, Giovanna, Agnoli, Claudia, De Magistris, Maria Santucci, Bueno-de-Mesquita, Bas, Derksen, Jeroen, Huybrechts, Inge, Ferrari, Pietro, Franklin, Oscar, Bodén, Stina, Schulze, Matthias, Huerta, Jose Maria, Barricarte, Aurelio, Sacerdote, Carlotta, Amiano, Pilar, Tumino, Rosario, Molina-Montes, Esther, Tjønneland, Anne, Kyrø, Cecilie, Severi, Gianluca, Boutron-Ruault, Marie Christine, Rebours, Vinciane, Katzke, Verena, Agudo, Antonio, and Jakszyn, Paula
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- 2022
44. The relationship between blood pressure and risk of renal cell carcinoma
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IRAS OH Epidemiology Chemical Agents, Alcala, Karine, Mariosa, Daniela, Smith-Byrne, Karl, Nasrollahzadeh Nesheli, Dariush, Carreras-Torres, Robert, Ardanaz Aicua, Eva, Bondonno, Nicola P, Bonet, Catalina, Brunström, Mattias, Bueno-De-Mesquita, Bas, Chirlaque, María-Dolores, Christakoudi, Sofia, Heath, Alicia K, Kaaks, Rudolf, Katzke, Verena, Krogh, Vittorio, Ljungberg, Börje, Martin, Richard M, May, Anne, Melander, Olle, Palli, Domenico, Rodriguez-Barranco, Miguel, Sacerdote, Carlotta, Stocks, Tanja, Tjønneland, Anne, Travis, Ruth C., Vermeulen, Roel, Chanock, Stephen, Purdue, Mark, Weiderpass, Elisabete, Muller, David, Brennan, Paul, Johansson, Mattias, IRAS OH Epidemiology Chemical Agents, Alcala, Karine, Mariosa, Daniela, Smith-Byrne, Karl, Nasrollahzadeh Nesheli, Dariush, Carreras-Torres, Robert, Ardanaz Aicua, Eva, Bondonno, Nicola P, Bonet, Catalina, Brunström, Mattias, Bueno-De-Mesquita, Bas, Chirlaque, María-Dolores, Christakoudi, Sofia, Heath, Alicia K, Kaaks, Rudolf, Katzke, Verena, Krogh, Vittorio, Ljungberg, Börje, Martin, Richard M, May, Anne, Melander, Olle, Palli, Domenico, Rodriguez-Barranco, Miguel, Sacerdote, Carlotta, Stocks, Tanja, Tjønneland, Anne, Travis, Ruth C., Vermeulen, Roel, Chanock, Stephen, Purdue, Mark, Weiderpass, Elisabete, Muller, David, Brennan, Paul, and Johansson, Mattias
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- 2022
45. Body size at different ages and risk of six cancers:a Mendelian randomization and prospective cohort study
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Mariosa, Daniela, Smith-Byrne, Karl, Richardson, Tom G, Ferrari, Pietro, Gunter, Marc J, Papadimitriou, Nikos, Murphy, Neil, Christakoudi, Sofia, Tsilidis, Konstantinos K, Riboli, Elio, Muller, David, Purdue, Mark P, Chanock, Stephen J, Hung, Rayjean J, Amos, Christopher I, O'Mara, Tracy A, Amiano, Pilar, Pasanisi, Fabrizio, Rodriguez-Barranco, Miguel, Krogh, Vittorio, Tjønneland, Anne, Halkjær, Jytte, Perez-Cornago, Aurora, Chirlaque, María-Dolores, Skeie, Guri, Rylander, Charlotta, Borch, Kristin Benjaminsen, Aune, Dagfinn, Heath, Alicia K, Ward, Heather A, Schulze, Matthias, Bonet, Catalina, Weiderpass, Elisabete, Smith, George Davey, Brennan, Paul, Johansson, Mattias, Mariosa, Daniela, Smith-Byrne, Karl, Richardson, Tom G, Ferrari, Pietro, Gunter, Marc J, Papadimitriou, Nikos, Murphy, Neil, Christakoudi, Sofia, Tsilidis, Konstantinos K, Riboli, Elio, Muller, David, Purdue, Mark P, Chanock, Stephen J, Hung, Rayjean J, Amos, Christopher I, O'Mara, Tracy A, Amiano, Pilar, Pasanisi, Fabrizio, Rodriguez-Barranco, Miguel, Krogh, Vittorio, Tjønneland, Anne, Halkjær, Jytte, Perez-Cornago, Aurora, Chirlaque, María-Dolores, Skeie, Guri, Rylander, Charlotta, Borch, Kristin Benjaminsen, Aune, Dagfinn, Heath, Alicia K, Ward, Heather A, Schulze, Matthias, Bonet, Catalina, Weiderpass, Elisabete, Smith, George Davey, Brennan, Paul, and Johansson, Mattias
- Abstract
It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23-2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09-1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
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- 2022
46. Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer:a multi-centre cohort study
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Kohls, Mirjam, Freisling, Heinz, Charvat, Hadrien, Soerjomataram, Isabelle, Viallon, Vivian, Davila-Batista, Veronica, Kaaks, Rudolf, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B, Dahm, Christina C, Tilma Vistisen, Helene, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Bonet, Catalina, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Masala, Giovanna, Palli, Domenico, Krogh, Vittorio, Ricceri, Fulvio, Rolandsson, Olov, Lu, Sai San Moon, Tsilidis, Konstantinos K, Weiderpass, Elisabete, Gunter, Marc J, Ferrari, Pietro, Berger, Ursula, Arnold, Melina, Kohls, Mirjam, Freisling, Heinz, Charvat, Hadrien, Soerjomataram, Isabelle, Viallon, Vivian, Davila-Batista, Veronica, Kaaks, Rudolf, Turzanski-Fortner, Renée, Aleksandrova, Krasimira, Schulze, Matthias B, Dahm, Christina C, Tilma Vistisen, Helene, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Bonet, Catalina, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Masala, Giovanna, Palli, Domenico, Krogh, Vittorio, Ricceri, Fulvio, Rolandsson, Olov, Lu, Sai San Moon, Tsilidis, Konstantinos K, Weiderpass, Elisabete, Gunter, Marc J, Ferrari, Pietro, Berger, Ursula, and Arnold, Melina
- Abstract
BACKGROUND: Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the mechanisms underlying these associations remain largely unexplored. We analysed these associations in colorectal and breast cancer patients.METHODS: Based on repeated BMI assessments of cancer-free participants from four European countries in the European Prospective Investigation into Cancer and nutrition (EPIC) study, individual BMI-trajectories reflecting predicted mean BMI between ages 20 to 50 years were estimated using a growth curve model. Participants with incident colorectal or breast cancer after the age of 50 years were included in the survival analysis to study the prognostic effect of mean BMI and cardiometabolic diseases (CMD) prior to cancer. CMD were defined as one or more chronic conditions among stroke, myocardial infarction, and type 2 diabetes. Hazard ratios (HRs) and confidence intervals (CIs) of mean BMI and CMD were derived using multivariable-adjusted Cox proportional hazard regression for mean BMI and CMD separately and both exposures combined, in subgroups of localised and advanced disease.RESULTS: In the total cohort of 159,045 participants, there were 1,045 and 1,620 eligible patients of colorectal and breast cancer. In colorectal cancer patients, a higher BMI (by 1 kg/m2) was associated with a 6% increase in risk of death (95% CI of HR: 1.02-1.10). The HR for CMD was 1.25 (95% CI: 0.97-1.61). The associations for both exposures were stronger in patients with localised colorectal cancer. In breast cancer patients, a higher BMI was associated with a 4% increase in risk of death (95% CI: 1.00-1.08). CMDs were associated with a 46% increase in risk of death (95% CI: 1.01-2.09). The estimates and CIs for BMI remained similar after adjustment for CMD and vice versa.CONCLUSIONS: Our results suggest that
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- 2022
47. Dietary greenhouse gas emissions and the risk of coronary heart disease and type 2 diabetes
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González, Carlos A., Bonet, Catalina, Huerta, José María, Amiano, Pilar, Rivera-Ferre, Marta G., González, Carlos A., Bonet, Catalina, Huerta, José María, Amiano, Pilar, and Rivera-Ferre, Marta G.
- Abstract
In a recent Article published in The Lancet Planetary Health, Jessica Laine and colleagues1 emphasised the relevance of the inter-relationship between dietary habits, human health, and planetary health. They showed an association of dietary greenhouse gas emissions with all-cause mortality and several forms of cause-specific mortality, and the incidence of cancer, based on a large cohort of almost half a million people from nine countries included in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
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- 2022
48. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
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MS MDL 1, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Nimptsch, Katharina, Aleksandrova, Krasimira, Fedirko, Veronika, Jenab, Mazda, Gunter, Marc J, Siersema, Peter D, Wu, Kana, Katzke, Verena, Kaaks, Rudolf, Panico, Salvatore, Palli, Domenico, May, Anne M, Sieri, Sabina, Bueno-de-Mesquita, Bas, Standahl, Karina, Sánchez, Maria-Jose, Perez-Cornago, Aurora, Olsen, Anja, Tjønneland, Anne, Bonet, Catalina Bonet, Dahm, Christina C, Chirlaque, María-Dolores, Fiano, Valentina, Tumino, Rosario, Gurrea, Aurelio Barricarte, Boutron-Ruault, Marie-Christine, Menegaux, Florence, Severi, Gianluca, van Guelpen, Bethany, Lee, Young-Ae, Pischon, Tobias, MS MDL 1, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Nimptsch, Katharina, Aleksandrova, Krasimira, Fedirko, Veronika, Jenab, Mazda, Gunter, Marc J, Siersema, Peter D, Wu, Kana, Katzke, Verena, Kaaks, Rudolf, Panico, Salvatore, Palli, Domenico, May, Anne M, Sieri, Sabina, Bueno-de-Mesquita, Bas, Standahl, Karina, Sánchez, Maria-Jose, Perez-Cornago, Aurora, Olsen, Anja, Tjønneland, Anne, Bonet, Catalina Bonet, Dahm, Christina C, Chirlaque, María-Dolores, Fiano, Valentina, Tumino, Rosario, Gurrea, Aurelio Barricarte, Boutron-Ruault, Marie-Christine, Menegaux, Florence, Severi, Gianluca, van Guelpen, Bethany, Lee, Young-Ae, and Pischon, Tobias
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- 2022
49. The relationship between blood pressure and risk of renal cell carcinoma
- Author
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Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Alcala, Karine, Mariosa, Daniela, Smith-Byrne, Karl, Nesheli, Dariush Nasrollahzadeh, Carreras-Torres, Robert, Aicua, Eva Ardanaz, Bondonno, Nicola P., Bonet, Catalina, Brunstrom, Mattias, Bueno-de-Mesquita, Bas, Chirlaque, Maria-Dolores, Christakoudi, Sofia, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Krogh, Vittorio, Ljungberg, Borje, Martin, Richard M., May, Anne, Melander, Olle, Palli, Domenico, Rodriguez-Barranco, Miguel, Sacerdote, Carlotta, Stocks, Tanja, Tjonneland, Anne, Travis, Ruth C., Vermeulen, Roel, Chanock, Stephen, Purdue, Mark, Weiderpass, Elisabete, Muller, David, Brennan, Paul, Johansson, Mattias, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Alcala, Karine, Mariosa, Daniela, Smith-Byrne, Karl, Nesheli, Dariush Nasrollahzadeh, Carreras-Torres, Robert, Aicua, Eva Ardanaz, Bondonno, Nicola P., Bonet, Catalina, Brunstrom, Mattias, Bueno-de-Mesquita, Bas, Chirlaque, Maria-Dolores, Christakoudi, Sofia, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Krogh, Vittorio, Ljungberg, Borje, Martin, Richard M., May, Anne, Melander, Olle, Palli, Domenico, Rodriguez-Barranco, Miguel, Sacerdote, Carlotta, Stocks, Tanja, Tjonneland, Anne, Travis, Ruth C., Vermeulen, Roel, Chanock, Stephen, Purdue, Mark, Weiderpass, Elisabete, Muller, David, Brennan, Paul, and Johansson, Mattias
- Published
- 2022
50. Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study
- Author
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Mariosa, Daniela, primary, Smith-Byrne, Karl, additional, Richardson, Tom G, additional, Ferrari, Pietro, additional, Gunter, Marc J, additional, Papadimitriou, Nikos, additional, Murphy, Neil, additional, Christakoudi, Sofia, additional, Tsilidis, Konstantinos K, additional, Riboli, Elio, additional, Muller, David, additional, Purdue, Mark P, additional, Chanock, Stephen J, additional, Hung, Rayjean J, additional, Amos, Christopher I, additional, O’Mara, Tracy A, additional, Amiano, Pilar, additional, Pasanisi, Fabrizio, additional, Rodriguez-Barranco, Miguel, additional, Krogh, Vittorio, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Perez-Cornago, Aurora, additional, Chirlaque, María-Dolores, additional, Skeie, Guri, additional, Rylander, Charlotta, additional, Borch, Kristin Benjaminsen, additional, Aune, Dagfinn, additional, Heath, Alicia K, additional, Ward, Heather A, additional, Schulze, Matthias, additional, Bonet, Catalina, additional, Weiderpass, Elisabete, additional, Davey Smith, George, additional, Brennan, Paul, additional, and Johansson, Mattias, additional
- Published
- 2022
- Full Text
- View/download PDF
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