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4 results on '"Boneschi, Filippo M."'

1. European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19

Author

Cardiovasculaire Epi Team 5, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Håkansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustín, Jansen, Jacobus F.A., Snyder, Heather, Kivipelto, Miia, Edison, Paul, Cardiovasculaire Epi Team 5, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Håkansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustín, Jansen, Jacobus F.A., Snyder, Heather, Kivipelto, Miia, and Edison, Paul

Published
2023

2. European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19

Author

Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'Avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Hakansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustin, Jansen, Jacobus F. A., Snyder, Heather, Kivipelto, Miia, Edison, Paul, Crook, Harry, Ramirez, Alfredo, Hosseini, Akram, Vavougyios, Georgios, Lehmann, Clara, Bruchfeld, Judith, Schneider, Anja, D'Avossa, Giovanni, Lo Re, Vincenzina, Salmoiraghi, Alberto, Mukaetova-Ladinska, Elizabeta, Katshu, Mohammad, Boneschi, Filippo M., Hakansson, Krister, Geerlings, Mirjam, Pracht, Elisabeth, Ruiz, Agustin, Jansen, Jacobus F. A., Snyder, Heather, Kivipelto, Miia, and Edison, Paul

Abstract

Background: The emergence of COVID-19 was rapidly followed by infection and the deaths of millions of people across the globe. With much of the research and scientific advancement rightly focused on reducing the burden of severe and critical acute COVID-19 infection, the long-term effects endured by those who survived the acute infection has been previously overlooked. Now, an appreciation for the post-COVID-19 condition, including its neurological manifestations, is growing, although there remain many unknowns regarding the etiology and risk factors of the condition, as well as how to effectively diagnose and treat it.Methods: Here, drawing upon the experiences and expertise of the clinicians and academics of the European working group on COVID-19, we have reviewed the current literature to provide a comprehensive overview of the neurological sequalae of the post-COVID-19 condition.Results: In this review, we provide a summary of the neurological symptoms associated with the post-COVID-19 condition, before discussing the possible mechanisms which may underly and manifest these symptoms. Following this, we explore the risk factors for developing neurological symptoms as a result of COVID-19 and the post-COVID-19 condition, as well as how COVID-19 infection may itself be a risk factor for the development of neurological disease in the future. Lastly, we evaluate how the post-COVID condition could be accurately diagnosed and effectively treated, including examples of the current guidelines, clinical outcomes, and tools that have been developed to aid in this process, as well as addressing the protection provided by COVID-19 vaccines against the post-COVID-19 condition.Conclusions: Overall, this review provides a comprehensive overview of the neurological sequalae of the post-COVID-19 condition. Impact statementWith our understanding of the neurological complications of the post-COVID-19 condition currently lacking sufficient depth, this review aimed at highlighting th

Published
2023

3. European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19

Author

Crook, Harry, primary, Ramirez, Alfredo, additional, Hosseini, Akram, additional, Vavougyios, Georgios, additional, Lehmann, Clara, additional, Bruchfeld, Judith, additional, Schneider, Anja, additional, D'Avossa, Giovanni, additional, Lo Re, Vincenzina, additional, Salmoiraghi, Alberto, additional, Mukaetova-Ladinska, Elizabeta, additional, Katshu, Mohammad, additional, Boneschi, Filippo M., additional, Håkansson, Krister, additional, Geerlings, Mirjam, additional, Pracht, Elisabeth, additional, Ruiz, Agustín, additional, Jansen, Jacobus F.A., additional, Snyder, Heather, additional, Kivipelto, Miia, additional, and Edison, Paul, additional

Published
2023
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4. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

Author

Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, and de Bakker PI

Subjects
Adolescent, Adult, Child, Female, Humans, Male, Middle Aged, Young Adult, Gene Frequency, Genome-Wide Association Study, Genotype, Odds Ratio, Disease Susceptibility, Genetic Predisposition to Disease, Multiple Sclerosis etiology, Multiple Sclerosis genetics, Polymorphism, Single Nucleotide
Abstract

Objective: To perform a 1-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional consequences of new susceptibility loci., Methods: We synthesized 7 MS GWAS. Each data set was imputed using HapMap phase II, and a per single nucleotide polymorphism (SNP) meta-analysis was performed across the 7 data sets. We explored RNA expression data using a quantitative trait analysis in peripheral blood mononuclear cells (PBMCs) of 228 subjects with demyelinating disease., Results: We meta-analyzed 2,529,394 unique SNPs in 5,545 cases and 12,153 controls. We identified 3 novel susceptibility alleles: rs170934(T) at 3p24.1 (odds ratio [OR], 1.17; p = 1.6 × 10(-8)) near EOMES, rs2150702(G) in the second intron of MLANA on chromosome 9p24.1 (OR, 1.16; p = 3.3 × 10(-8)), and rs6718520(A) in an intergenic region on chromosome 2p21, with THADA as the nearest flanking gene (OR, 1.17; p = 3.4 × 10(-8)). The 3 new loci do not have a strong cis effect on RNA expression in PBMCs. Ten other susceptibility loci had a suggestive p < 1 × 10(-6) , some of these loci have evidence of association in other inflammatory diseases (ie, IL12B, TAGAP, PLEK, and ZMIZ1)., Interpretation: We have performed a meta-analysis of GWAS in MS that more than doubles the size of previous gene discovery efforts and highlights 3 novel MS susceptibility loci. These and additional loci with suggestive evidence of association are excellent candidates for further investigations to refine and validate their role in the genetic architecture of MS., (Copyright © 2011 American Neurological Association.)

Published
2011
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