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Background: An ideal aesthetic restorative material should be attached to the tooth tissues by adhesion, have a smooth surface as possible, should not cause toxic reactions in the pulp and discoloration and microleakage. This study aims at comparatively assess the cytotoxicity of current adhesive systems on human dental pulp cells. Materials and methods: The adequate density of human pulp cells was observed from the ready cell line. The passaging was performed and the 3rd passage cells were selected. Adhesive systems and MTA were used on the cultures. Trypan blue staining was conducted on the cells at the 1st, 2nd, 3rd days and a count of live and dead cells using a light microscope. The dead cells whose membrane integrity was impaired by staining with trypan blue and the viability rate was determined using live and dead cell numbers. Data analysis was performed using IBM SPSS Statistics 22. Results: A significant difference in vialibity rates between adhesive systems was observed on the first day. No significant statistical differences were observed on the 2nd and 3rd days (p < 0.05). Conclusion: Futurabond M showed similar biocompatibility with MTA on human pulp cells and it can be applied in cavities with 1–1.5 mm hard tissue between pulp and dentine. [ABSTRACT FROM AUTHOR]

Abstract Background An ideal aesthetic restorative material should be attached to the tooth tissues by adhesion, have a smooth surface as possible, should not cause toxic reactions in the pulp and discoloration and microleakage. This study aims at comparatively assess the cytotoxicity of current adhesive systems on human dental pulp cells. Materials and methods The adequate density of human pulp cells was observed from the ready cell line. The passaging was performed and the 3rd passage cells were selected. Adhesive systems and MTA were used on the cultures. Trypan blue staining was conducted on the cells at the 1st, 2nd, 3rd days and a count of live and dead cells using a light microscope. The dead cells whose membrane integrity was impaired by staining with trypan blue and the viability rate was determined using live and dead cell numbers. Data analysis was performed using IBM SPSS Statistics 22. Results A significant difference in vialibity rates between adhesive systems was observed on the first day. No significant statistical differences were observed on the 2nd and 3rd days (p

Statement of the Problem: Immediate dentin sealing (IDS) was introduced to overcome the disadvantages of delayed dentin sealing like pollution of dentin tubules, microleakage, and bond strength destruction over time. The effect of IDS on the bond strength of indirect restorations is still debatable.Purpose: This study was conducted to determine the effect of IDS on the bond strength of ceramic restorations to dentin.Materials and Method: In this systematic review and meta-analysis, the study protocol was registered on the PROSPERO database under the registration number CRD420202014 27. MEDLINE (PubMed), Web of Science, Scopus, and ProQuest databases were searched until January 2021 and updated in January 2022. Worldcat.org and Opengrey.eu, ProQuest dissertation and thesis, and Google Scholar were searched to explore the grey literature. The in vitro studies evaluating the bond strength of ceramic restoration to dentin with and without IDS were included. Seven criteria were assessed to evaluate the risk of bias in the study. Statistical analyses were conducted using RevMan 5.3. The inverse variance method was used to determine the mean difference of micro-tensile bond strength (µTBS) and shear bond strength (SBS).Results: A total of 10 studies (20 datasets) were included in the meta-analysis. Regarding the µTBS analysis, IDS had a significantly higher bond strength than Delayed Dentin Sealing (DDS) (MD:1.16, 95%CI:0.28_2.03, I2=0%). However, no significant difference was found between them in the SBS analysis (MD:0.25, 95%CI: -0.56-1.06, I2=96%). All studies were categorized to have a moderate or high risk of bias.Conclusion: Most in vitro evidence showed favorable results for the effect of IDS on the bond strength and durability of indirect restorations. The adhesive system and the type of ceramic and its treatment before cementation are determining factors. Due to the heterogeneity of the outcomes and studies with a moderate/high risk of bias, the quality of the evidence was low.

Statement of the Problem: Immediate dentin sealing (IDS) was introduced to overcome the disadvantages of delayed dentin sealing like pollution of dentin tubules, microleakage, and bond strength destruction over time. The effect of IDS on the bond strength of indirect restorations is still debatable. Purpose: This study was conducted to determine the effect of IDS on the bond strength of ceramic restorations to dentin. Materials and Method: In this systematic review and meta-analysis, the study protocol was registered on the PROSPERO database under the registration number CRD420202014 27. MEDLINE (PubMed), Web of Science, Scopus, and ProQuest databases were searched until January 2021 and updated in January 2022. Worldcat.org and Opengrey.eu, ProQuest dissertation and thesis, and Google Scholar were searched to explore the grey literature. The in vitro studies evaluating the bond strength of ceramic restoration to dentin with and without IDS were included. Seven criteria were assessed to evaluate the risk of bias in the study. Statistical analyses were conducted using RevMan 5.3. The inverse variance method was used to determine the mean difference of micro-tensile bond strength (µTBS) and shear bond strength (SBS). Results: A total of 10 studies (20 datasets) were included in the meta-analysis. Regarding the µTBS analysis, IDS had a significantly higher bond strength than Delayed Dentin Sealing (DDS) (MD:1.16, 95%CI:0.28_2.03, I² =0%). However, no significant difference was found between them in the SBS analysis (MD:0.25, 95%CI: -0.56-1.06, I² =96%). All studies were categorized to have a moderate or high risk of bias. Conclusion: Most in vitro evidence showed favorable results for the effect of IDS on the bond strength and durability of indirect restorations. The adhesive system and the type of ceramic and its treatment before cementation are determining factors. Due to the heterogeneity of the outcomes and studies with a moderate/high risk of bias, the quality of the evidence was low. [ABSTRACT FROM AUTHOR]

Despite the rise in popularity of ceramic braces for adults, the risk of enamel microcracks (EMCs) upon removal remains a significant drawback for both dental professionals and patients. Our study aimed to assess the effects of thermocycling, pre-curing, and co-curing techniques with different bonding agents on the enamel surface of teeth after the removal of ceramic brackets. We also examined the incidence, quantity, length, and direction of EMCs on tooth surfaces. Additionally, the adhesive remnant index (ARI) scores and orthodontic bracket bond failure modes were evaluated and compared. The study divided 40 extracted upper canine teeth into ten groups for further analysis. Two groups had intact enamel as the negative control, while the remaining groups had orthodontic ceramic brackets bonded using different bonding agents and curing techniques. Thermocycling was performed in five groups, and ARI was assessed after debonding. The study findings were statistically significant (p < 0.05) in demonstrating the impact of curing techniques on EMCs and debonding outcomes. Seventh-generation bonding agents resulted in complete adhesive removal (ARI = 0). The microcracks' incidence, number, and length showed insignificant results. Differences in ARI between thermocycler and non-thermocycler samples were insignificant. Both co-curing and pre-curing techniques yielded comparable ARI results. This study highlights the importance of using advanced bonding agents to minimize enamel damage during ceramic bracket debonding. [ABSTRACT FROM AUTHOR]

Abstract Background Dentin hypersensitivity (DH) is one of the most challenging and persistent dental complaints characterized by transient, intense pain triggered by various stimuli. It affects a significant portion of the global population, predominantly those aged 20–40. This study aims to evaluate the desensitizing efficacy of seventh-generation dentin bonding agents (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) against a control group using Bifluorid 12 by Voco in mitigating DH within a month of the follow-up period. Methods This was a single-center, parallel-group, double-blind, controlled randomized clinical trial conducted at Dow University of Health Sciences, Karachi, Pakistan. A total of 105 patients with DH were allocated into three groups for this study. The patients were divided into three groups (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) and the control group containing fluoride varnish (Bifluorid 12 by Voco). Discomfort Interval Scale scores and Schiff Cold Air Sensitivity Scale scores were recorded at baseline, immediately after the intervention, after 01 weeks, and after 01 month. Results All the materials demonstrated a statistically significant reduction in discomfort and sensitivity (DIS scores p-value 0.01) immediately after 01 week and over a period of 01 month after treatment compared with the baseline scores before application, with no single material proving superior over the one-month observation period. The study also provided insights into dental hygiene practices, with a significant majority using a toothbrush and sensitivity patterns, with cold stimuli being the most common cause of sensitivity. Conclusion The study demonstrates that Single Bond Universal, Xeno V+, and Bifluorid 12 are equally effective in reducing dentin hypersensitivity, with no distinct superiority observed over a one-month period. The findings highlight the potential of fluoride varnishes as a less technique-sensitive and cost-effective option for treating DH, offering valuable insights for future research and clinical practice. Trial registration NCT04225247 ( https://clinicaltrials.gov/study/NCT04225247 ), Date of Registration: 13/01/2020. (Retrospectively registered).

Background: Dentin hypersensitivity (DH) is one of the most challenging and persistent dental complaints characterized by transient, intense pain triggered by various stimuli. It affects a significant portion of the global population, predominantly those aged 20–40. This study aims to evaluate the desensitizing efficacy of seventh-generation dentin bonding agents (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) against a control group using Bifluorid 12 by Voco in mitigating DH within a month of the follow-up period. Methods: This was a single-center, parallel-group, double-blind, controlled randomized clinical trial conducted at Dow University of Health Sciences, Karachi, Pakistan. A total of 105 patients with DH were allocated into three groups for this study. The patients were divided into three groups (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) and the control group containing fluoride varnish (Bifluorid 12 by Voco). Discomfort Interval Scale scores and Schiff Cold Air Sensitivity Scale scores were recorded at baseline, immediately after the intervention, after 01 weeks, and after 01 month. Results: All the materials demonstrated a statistically significant reduction in discomfort and sensitivity (DIS scores p-value 0.01) immediately after 01 week and over a period of 01 month after treatment compared with the baseline scores before application, with no single material proving superior over the one-month observation period. The study also provided insights into dental hygiene practices, with a significant majority using a toothbrush and sensitivity patterns, with cold stimuli being the most common cause of sensitivity. Conclusion: The study demonstrates that Single Bond Universal, Xeno V+, and Bifluorid 12 are equally effective in reducing dentin hypersensitivity, with no distinct superiority observed over a one-month period. The findings highlight the potential of fluoride varnishes as a less technique-sensitive and cost-effective option for treating DH, offering valuable insights for future research and clinical practice. Trial registration: NCT04225247 (https://clinicaltrials.gov/study/NCT04225247), Date of Registration: 13/01/2020. (Retrospectively registered). [ABSTRACT FROM AUTHOR]

Ammonium dinitramide (ADN) has appeared as a promising oxidizer for green propellants and thereby a potential substitute for ammonium perchlorate, largely in use in composite propellants for tactical and strategic long‐range missiles. The novelty lies in replacing ammonium perchlorate with a chlorine‐free oxidizer less harmful to the health and environment. However, ADN is hygroscopic and can potentially react with other chemical components, which could be overcome by microencapsulating the particles. The simple coacervation method was tested herein to microencapsulate ADN with a membrane made of hydroxyl‐terminated polybutadiene as pre‐polymer and methylene diphenyl diisocyanate as the curing agent. The effect of polyamine bonding agents on the capsule formation was tested by adding 0.5 or 2 % of Tepan or Tepanol, whose efficacy to bond to ADN was confirmed by detecting ammonia release through infrared spectroscopy. The capsule membrane was examined by optical and scanning electron microscopy. The dissolution time and rate were the parameters adopted to quantify permeability in a straight dissolution test in water, which demonstrated that 0.5 % Tepanol can provide the most effective protection. The infrared spectroscopy indicated that 60 °C temperature for prolonged periods, normally experienced by propellants, does not chemically affect the capsules' membrane but can turn it lumpy. In conclusion, these polyamine bonding agents can assist the capsule formation over ADN particles using the simple coacervation method, however, their functionality on mechanical properties of propellants needs to be substantiated in forthcoming works as well as the effect of the concentration of bonding agents on propellant formulations. [ABSTRACT FROM AUTHOR]

Objective: This research is meant to evaluate the effectiveness of different bonding agents in minimally invasive cavity preparations at a tertiary care center. Materials and Methods: A prospective research was conducted involving patients requiring minimally invasive cavity preparations. Patients were randomly assigned to groups based on the bonding agent used. Standardized cavity preparations were performed, and bonding agent application followed manufacturer instructions. Outcome measures included bond strength and marginal adaptation. Data were analyzed using appropriate statistical methods. Results: Bonding Agent A exhibited the highest mean bond strength (25.6 MPa) and superior marginal adaptation (mean score: 4.2) compared to Bonding Agents B and C. These differences were statistically significant (P < 0.001 for bond strength, P < 0.05 for marginal adaptation). Conclusion: Bonding Agent A demonstrated superior performance in achieving durable and esthetically pleasing restorations in minimally invasive cavity preparations. These findings underscore the importance of selecting appropriate bonding agents for conservative dental treatments to optimize treatment outcomes and patient satisfaction.

Naji Ziad Arandi Department of Conservative Dentistry, Faculty of Dentistry, Arab American University, Jenin, PalestineCorrespondence: Naji Ziad Arandi, Department of Conservative Dentistry, Faculty of Dentistry, Arab American University, Jenin, Palestine, Tel +972598126111, Email naji.arandi@aaup.eduAbstract: Adhesive agents are essential to most restorative procedures used in everyday practice. Depending on the clinical situation, the dentist will choose among a rapidly evolving variety of adhesive agents (bonding agents). Due to the availability of many adhesive agents, appropriate selection can take time and effort. Typically, a practitioner relies more on marketing and experience than in-depth material knowledge. The classification of adhesive agents may need to be clarified and easier to remember due to its lack of relevance to clinical procedures. This paper reviews the published literature retrieved from PubMed, Google Scholar, and Scopus by using specific keywords “adhesive agents”, “classification”, “dentin”, “enamel”, “universal”, “self-etch”, “etch-and-rinse”, and “bonding”. The titles and abstracts were screened, and the relevant literature was retrieved. The list of references from each identified article was examined to find other potentially relevant articles. Adhesive agents can be classified as etch-and-rinse, self-etch, or “multi-mode” according to their approach to interacting with the smear layer, and each approach can be further classified according to the number of clinical steps required during application. This article reviews the classification of current adhesive agents and discusses the properties that make a specific adhesive agent the optimal choice for a particular clinical indication. The review will assist the general dentist in understanding the various types of available adhesive agents and how they function. Overall, the review will facilitate decision-making and allow the selection of appropriate materials.Keywords: adhesive agents, bonding agents, classification, dentine, enamel, etch-and-rinse, self-etch, universal adhesives

Background: Postendodontic restoration with composite resins has gained popularity due to the development of more reliable adhesives with simplified bonding procedures and less technique sensitivity. Pulpal floor dentin is a complex biological structure and a more challenging bonding substrate. Hence, appropriate selection of the bonding agent for these regions of the tooth is important. Aims: To compare the shear bond strength of a new generation of dental adhesives referred to as multimode adhesives, two-step self-etch adhesive, and a total-etch system to pulpal floor dentin. Materials and Methods: Sixty human mandibular molars were sectioned with a slow speed diamond disc to expose the pulp chamber and divided into four groups of 15 teeth each, based on the bonding agent used. Group A: Single bond universal (self-etch); Group B: Single Bond Universal (etch-and-rinse), Group C: Clearfil SE Bond, Group D: Adper Single Bond 2. Using a split Teflon mold, composite cylinders were built on the prepared dentinal surfaces. The shear bond strength was then evaluated with the universal testing machine. Results: Two step self-etch adhesives recorded higher shear bond strength than total-etch and multimode/universal adhesives applied in both self-etch and etch-and-rinse techniques. Conclusion: The self-etching/priming system bonded more strongly to the pulpal floor dentin than multimode adhesive and total-etch system.

Background: Postendodontic restoration with composite resins has gained popularity due to the development of more reliable adhesives with simplified bonding procedures and less technique sensitivity. Pulpal floor dentin is a complex biological structure and a more challenging bonding substrate. Hence, appropriate selection of the bonding agent for these regions of the tooth is important. Aims: To compare the shear bond strength of a new generation of dental adhesives referred to as multimode adhesives, two-step self-etch adhesive, and a total-etch system to pulpal floor dentin. Materials and Methods: Sixty human mandibular molars were sectioned with a slow speed diamond disc to expose the pulp chamber and divided into four groups of 15 teeth each, based on the bonding agent used. Group A: Single bond universal (self-etch); Group B: Single Bond Universal (etch-and-rinse), Group C: Clearfil SE Bond, Group D: Adper Single Bond 2. Using a split Teflon mold, composite cylinders were built on the prepared dentinal surfaces. The shear bond strength was then evaluated with the universal testing machine. Results: Two step self-etch adhesives recorded higher shear bond strength than total-etch and multimode/universal adhesives applied in both self-etch and etch-and-rinse techniques. Conclusion: The self-etching/priming system bonded more strongly to the pulpal floor dentin than multimode adhesive and total-etch system. [ABSTRACT FROM AUTHOR]

Unexpected results and negligence can lead to mishaps in the dental operatory. With the trend of using tooth-colored restorations, mishaps have also increased, which are sometimes ignored due to a lack of knowledge. Although resin-based restorative materials are considered safe, their constituents can leach out and cause allergies in patients as well as dental professionals. Safe-handling of these resin-based materials is critical due to increased risk of occupational health hazards. Most of the allergies caused by resins are related to monomers based on methacrylic acid, which is found in almost all types of dentin bonding agents. Also, it is estimated that 5%–10% of all allergic contact dermatitis reports in dental professionals are due to contact with methacrylate. On the contrary, 37% phosphoric acid in etchant results in necrosis and ulcerative lesions due to vascular nature of the oral cavity. The purpose of this article is to help dentists to become aware of allergies/mishaps that can occur due to bonding agents and phosphoric acid, thereby leading to prevention and their early management. [ABSTRACT FROM AUTHOR]

Background and Objective: Due to the importance of primary anterior teeth in chewing, pronunciation of words, self-confidence, facial appearance of children, efforts to preserve these teeth continue. The aim of the present study was to evaluate the push-out bond strength of 5th, 6th, 7th, and 8th generation bonding agents to intracanal dentin of primary anterior teeth which are reconstructed with the composite posts. Methods: The present experimental in vitro study was conducted on 60 extracted primary anterior teeth with at least two-thirds of the root length remaining. The teeth were randomly divided into five groups: 5th generation (3M Adper single bond 2 Adhesive-USA), 6th generation (clearfil SE bond, Japan), 7th generation (kerr-optibond all in one Adhesive-Italy), and 8th generation total-etch and 8th generation self-etch (GC-G permio bond-Japan) bonding agents. After root canal preparation, prepared canals were filled with Metapex. The coronal 3mm of the canals was etched and impregnated with the dentin bonding agents. Then, they were restored with composite. The push-out test was performed to evaluate the bond strength of adhesives. Accordingly, by a light microscope the failure modes were determined. Findings: The mean bond strength of 5th, 6th, 7th, and 8th generation (self-etch, total-etch) bonding agents was 4.36±2.15, 3.88±1.55, 4.29±2.02, 12.84±3.62, and 7.77±3.81 MPa, respectively. The push-out bond strength of the 8th generation bonding agent using both self-etch (p=0.000) and totaletch techniques was higher than the 5th, 6th, and 7th generation bonding agents (p=0.032, 0.01, 0.027, respectively). No significant difference was found between the bond strength of the 5th, 6th, and 7th generation bonding agents. Conclusion: The push-out bond strength of the 8th generation bonding system was higher than the other groups. Therefore, the 8th generation bonding agents can be used to bond composite posts to intracanal dentin of primary anterior teeth. Also, self-etch (8th generation) has higher bond strength compared to the total-etch technique. [ABSTRACT FROM AUTHOR]

Background and Objective: Microleakage is one of the most important causes of failure in restoration and secondary caries. This study was conducted in order to compare dentinal microleakage of class II composite restorations using Universal Dental Adhesive, with and without liner. Methods: In this laboratory study, two Class II cavities were prepared in the mesial and distal surfaces of 48 healthy premolar teeth. Then, the samples were divided into 6 groups of 8 according to the application method of Single Bond Universal adhesive and liner: selective etching of enamel (SEE), self-etch (SE) technique, SEE technique and resin-modified glass-ionomer (RMGI) liner, SE technique and RMGI Liner, SEE technique and Flow Liner, and SE technique and Flow Liner. Restoration was done with Filtek Z250 composite. Microleakage was evaluated and compared using 2% fuchsine based on intensity 0 to 3. Findings: In the SEE group, 56.2% of restorations did not have microleakage. 31.2% had grade 3 microleakage and 12.5% had grade 1 microleakage. However, in the SEE+RMGI group, 81.25% and the SEE+Flow group, 81.2% of the restorations had no microleakage. In the SE group, 18.7% of restorations showed zero microleakage, 50% showed grade 3 microleakage, and 31.2% showed grade 2 microleakage. However, in the SE+RMGI group, 81.25% and in the SE+Flow group, 93.7% of the restorations did not have microleakage. The distribution of dentinal microleakage intensity between SEE and SE methods (p=0.067) and between SEE+RMGI and SEE+Flow groups (p=0.194) was not significant. However, in the SE+Flow and SE+RMGI groups, this difference was significant (p

Despite the huge improvements made in adhesive technology over the past 50 years, there are still some unresolved issues regarding the durability of the adhesive interface. A complete sealing of the interface between the resin and the dentin substrate remains difficult to achieve, and it is doubtful whether an optimal interdiffusion of the adhesive system within the demineralized collagen framework can be produced in a complete and homogeneous way. In fact, it is suggested that hydrolytic degradation, combined with the action of dentin matrix enzymes, destabilizes the tooth-adhesive bond and disrupts the unprotected collagen fibrils. While a sufficient resin–dentin adhesion is usually achieved immediately, bonding efficiency declines over time. Thus, here, a review will be carried out through a bibliographic survey of scientific articles published in the last few years to present strategies that have been proposed to improve and/or develop new adhesive systems that can help prevent degradation at the adhesive interface. It will specially focus on new clinical techniques or new materials with characteristics that contribute to increasing the durability of adhesive restorations and avoiding the recurrent replacement restorative cycle and the consequent increase in damage to the tooth.

Several lubricant materials can be used to model resin-based composites (RBCs) during restorative procedures. Clinically, instruments or brushes are wet with bonding agents (BAs) or modeling liquids (MLs) for sculpturing purposes. However, a knowledge gap exists on their effects on the mechanical properties of RBCs, requiring greater insight. Five databases were searched, including 295 in vitro studies on the use of lubricant materials for modeling RBCs during restorative procedures. Only articles in the English language were included, with no limits on the publication date. The last piece of research was dated 24 March 2022. In total, 16 studies were included in the review process, together with a paper retrieved after screening references. A total of 17 BAs and 7 MLs were investigated. Tensile (n = 5), flexural strength (n = 2), water sorption (n = 2), color stability (n = 8) and translucency (n = 3), micro-hardness (n = 4), roughness (n = 3), degree of conversion (n = 3), and monomer elution (n = 2) tests were carried out. In general, a maximum of 24 h of artificial storage was performed (n = 13), while four papers tested the specimens immediately. The present review identifies the possibilities and limitations of modeling lubricants used during restorative procedures on the mechanical, surface, and optical properties of RBCs. Clinicians should be aware that sculpturing RBCs with modeling resins might influence the composite surface properties in a way that is material-dependent. [ABSTRACT FROM AUTHOR]

The clinical effectiveness of adhesive agents has been mainly evaluated using class V restorations. Clinical studies evaluating adhesives in combination with posterior composites are scarce and of short-term periods. This paper is aimed to review the current literature on the clinical effectiveness of contemporary adhesives when used to restore posterior teeth (Class I and Class II). To conduct this review, Scopus, PubMed, and Google Scholar databases were used to search for peer-reviewed articles on the clinical performance of adhesive agents in posterior composite restorations. Search terms used included “adhesive agents,” “clinical evaluation,” “composite restorations,” “posterior teeth,” “self-etch adhesives,” “etch -and -rinse adhesives,” and “universal adhesives.” To enrich the results, reference mining of the articles that were identified was used to locate other papers. The process of cross-referencing continued until no new articles were identified. No limits were placed on the year of publication, but only articles in English were considered. The current review found that simplification in the adhesive technique so far seems to affect the clinical performance. There is a relative paucity of evidence relating to the performance of universal adhesive agents in posterior restorations. Further long-term clinical studies are needed to evaluate the clinical performance of adhesive agents.

Background and Objective: Microleakage is one of the most important causes of failure in restoration and secondary caries. This study was conducted in order to compare dentinal microleakage of class II composite restorations using Universal Dental Adhesive, with and without liner. Methods: In this laboratory study, two Class II cavities were prepared in the mesial and distal surfaces of 48 healthy premolar teeth. Then, the samples were divided into 6 groups of 8 according to the application method of Single Bond Universal adhesive and liner: selective etching of enamel (SEE), self-etch (SE) technique, SEE technique and resin-modified glass-ionomer (RMGI) liner, SE technique and RMGI Liner, SEE technique and Flow Liner, and SE technique and Flow Liner. Restoration was done with Filtek Z250 composite. Microleakage was evaluated and compared using 2% fuchsine based on intensity 0 to 3. Findings: In the SEE group, 56.2% of restorations did not have microleakage. 31.2% had grade 3 microleakage and 12.5% had grade 1 microleakage. However, in the SEE+RMGI group, 81.25% and the SEE+Flow group, 81.2% of the restorations had no microleakage. In the SE group, 18.7% of restorations showed zero microleakage, 50% showed grade 3 microleakage, and 31.2% showed grade 2 microleakage. However, in the SE+RMGI group, 81.25% and in the SE+Flow group, 93.7% of the restorations did not have microleakage. The distribution of dentinal microleakage intensity between SEE and SE methods (p=0.067) and between SEE+RMGI and SEE+Flow groups (p=0.194) was not significant. However, in the SE+Flow and SE+RMGI groups, this difference was significant (p<0.001). Conclusion: The results of this study showed that in the method of using a liner with Universal adhesive, dentinal microleakage in class II composite restoration decreased. [ABSTRACT FROM AUTHOR]

ABSTRACT Introduction: Orthodontic treatment for adults is currently increasing, and therefore the need to bond brackets to restorations and temporary crowns. The use of CAD/CAM PMMA provisional restorations for orthodontic purposes have not yet been described, and there is currently insufficient information regarding the strength of bracket adhesion. Objective: This study aimed at evaluating the effects of thermocycling (TC) and surface treatment on shear bond strength (SBS) of brackets to different provisional materials. Methods: Forty specimens were made from each material [PMMA (Telio Lab), bis-acryl (Telio CS C&B), and PMMA CAD/CAM (Telio CAD)], sandpapered, and divided according to surface treatment (pumiced or sandblasted) and TC (half of the samples = 1,000 cycles, 5°C/55°C water baths) (n = 10/group). Stainless-steel brackets were bonded to the specimens (using Transbond XT), and SBS testing was performed. Data were analyzed by three-way ANOVA and LSD post-hoc tests (α = 0.05). Failure types were classified with adhesive remnant index (ARI) scores. Results: SBS values ranged from 1.5 to 14.9 MPa. Sandblasted bis-acryl and sandblasted auto-curing PMMA groups presented similar values (p> 0.05), higher than the CAD/CAM material (p< 0.05), with or without TC. When thermocycled, pumiced bis-acryl showed higher SBS than pumiced acrylic (p= 0.005) and CAD/CAM materials (p= 0.000), with statistical difference (p= 0.009). TC showed negative effect (p< 0.05) for sandblasted bis-acryl and pumiced acrylic groups. ARI predominant score was mostly zero (0) for CAD/CAM, 1 and 2 for bis-acryl, and 1 for acrylic groups. Conclusion: In general, bis-acryl material showed the highest SBS values, followed by acrylic and CAD/CAM materials, which showed SBS values lower than an optimum strength for bonding brackets.

Introduction: This study evaluated microleakage of flowable and conventional composite in primary molar class II restorations using self-etch and total-etch bonding agents. Methods: Class II standard cavities were prepared on proximal surface of 48 primary molars. These cavities were restored using GrandioFlow and Grandio composites and Futurabond DC and Solobond M as bonding agents. Teeth apices were sealed by wax and two-layer nail varnish was applied up to 1mm of restoration margins. Samples were subjected to thermocycling, stained by silver nitrate solution and sectioned mesiodistally. Microleakage was measured from the tooth-restoration margin to end point of dye penetration using a stereomicroscope with a 0-3 scale. Microleakage scores were analyzed using Kruskal-Wallis test in 4 groups and paired comparisons were performed using Monte Carlo test. Results: Microleakage was seen in all composite and bonding agent groups. Pairwise comparison showed no significant difference regarding the microleakage between groups ( P>0.05) . Conclusion: Gradioflow as a flowable composite and Futurabond DC as a self-etch bonding agent both showed acceptable results in regard to microleakage. Considering the ease of application of flowable composites compared to conventional ones and shortening the treatment both flowable composites and self-etch bonding agentshave showed promising results in pediatric dentistry

Background: Bonded composites may increase bacterial accumulation and caries formation risk. Therefore, assessment of methods to decrease bacterial activity around them would be valuable. The literature on the efficacy of adding silver nanoparticles to fiber-reinforced composite (FRC) or adding them to bonding agents in terms of their antibacterial activity and/or shear bond strength (SBS) is scarce. Thus, we aimed to assess the antibacterial activity of flowable composites and bonding agents containing various percentages of experimental silver nanoparticles (nanosilver) against S. mutans and to evaluate the SBS of FRC and bonding agents containing different amounts of nanosilver to enamel. Materials and Methods: In this preliminary study, 0% (control), 0.5%, 1%, 2.5%, and 5% nanosilver were added to flowable composite and bonding agent. Syntheses of nanosilver and nanosilver-incorporated composite specimens were approved using X-ray diffraction spectroscopy and scanning electron microscopy. Antibacterial effects of the produced materials on S. mutans were evaluated by colony count with serial dilution method (n = 7 groups × 10 [n = 70] specimens) and agar disc diffusion test (n = 6 groups × 5 [n = 30] composite specimens + n = 6 groups × 5 [n = 30] light-cured bonding + n = 6 groups × 5 [n = 30] uncured bonding) against negative control and cefotaxime antibiotic. Moreover, SBS values of various FRC blocks bonded to enamel using various bonding agents were measured (n = 9 groups × 6 [n = 54] human premolars). Data were analyzed using Kruskal–Wallis, Dunn, two-way analysis of variance, and Tukey's tests (α = 0.05). Results: Composite discs containing all concentrations of nanosilver reduced S. mutans colony counts (P < 0.05); bacterial growth was ceased at samples containing 2.5% and 5% of nanosilver. The reduction in the SBS of FRCs was significant only for 5% nanosilver (P < 0.05). Conclusion: Adding 0.5%, 1%, and 2.5% nanosilver to composite and 0.5% or 1% nanosilver to bonding agent led to a significant antibacterial behavior against S. mutans while not significantly affecting the SBS of FRC.

Aim: The current study's aim was to evaluate the orthodontic bracket's bond strength employing three different bonding agents on a ceramic crown surface., Materials and Methods: Tooth preparation on 60 permanent maxillary premolar teeth extracted for orthodontic purposes was carried out. Supragingival finishing margins were made for all samples, and ceramic (PFM) crowns were fabricated. Following crown cementation on the prepared samples, they were divided into three experimental groups randomly ( n = 20) as follows: group I: Bracket bonding using Transbond XT bonding agent; group II: Bracket bonding using RelyX TM Unicem bonding agent; and group III: Bracket bonding using Assure Plus bonding agent. A universal testing machine was utilized to conduct the shear bond strength test. Using a stereomicroscope with a 10× magnification, adhesive remnant index scores were also used to assess the adhesive that was remaining on the surfaces. Data was recorded and statistically analyzed., Results: The highest bond strength was found in RelyX TM Unicem bonding agent (19.38 ± 0.84) followed by Transbond XT bonding agent (17.12 ± 1.04) and Assure Plus bonding agent (16.14 ± 1.02). A highly significant difference was found between Transbond XT vs RelyX TM Unicem groups and RelyX TM Unicem vs Assure Plus groups. There was no significant difference found between Transbond XT and Assure Plus ( p > 0.001). Adhesive Remnant Index scores showed that score 1 was higher [7 (35%)] in the Transbond XT bonding agent group. Score 1 was 8 (40%) and score 2 was 6 (30%) in RelyX TM Unicem bonding agent groups and in Assure Plus bonding agent group, score 2 was higher [9 (45%)]., Conclusion: In conclusion, RelyX TM Unicem exhibited superior bond strength with ceramic crowns when compared to Assure Plus and Transbond XT bonding agents., Clinical Significance: One of the most important steps in orthodontic therapy is bonding brackets to the teeth. A high enough and long-lasting bond between brackets and artificial surfaces is necessary for orthodontic treatment to be successful, as is the requirement for a bonding agent with the highest possible binding strength. The necessity for a more dependable process to glue the artificial crown surface has arisen due to the rise in adult patients seeking fixed orthodontic treatment. How to cite this article: Brajendu, Haque I, Sam G, et al. Assessment of the Bond Strength of Orthodontic Bracket on Ceramic Crown Surface Using Three Various Bonding Agents: A Comparative Study. J Contemp Dent Pract 2024;25(8):762-765.

Objective: This research is meant to evaluate the effectiveness of different bonding agents in minimally invasive cavity preparations at a tertiary care center., Materials and Methods: A prospective research was conducted involving patients requiring minimally invasive cavity preparations. Patients were randomly assigned to groups based on the bonding agent used. Standardized cavity preparations were performed, and bonding agent application followed manufacturer instructions. Outcome measures included bond strength and marginal adaptation. Data were analyzed using appropriate statistical methods., Results: Bonding Agent A exhibited the highest mean bond strength (25.6 MPa) and superior marginal adaptation (mean score: 4.2) compared to Bonding Agents B and C. These differences were statistically significant ( P < 0.001 for bond strength, P < 0.05 for marginal adaptation)., Conclusion: Bonding Agent A demonstrated superior performance in achieving durable and esthetically pleasing restorations in minimally invasive cavity preparations. These findings underscore the importance of selecting appropriate bonding agents for conservative dental treatments to optimize treatment outcomes and patient satisfaction., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Pharmacy and Bioallied Sciences.)

Objectives: This study aimed to assess the microshear bond strength (MSBS) of Scotchbond Universal adhesive, used in self-etch and etch-and-rinse modes, to primary and permanent dentin at 24 hours and six months. Materials and Methods: A total of 88 composite micro-cylinders were divided into eight groups (n=11) as follows: (A) Etch-and-rinse, 24 hours, primary dentin; (B) Self-etch, 24 hours, primary dentin; (C) Etch-and-rinse, six months, primary dentin; (D) Self-etch, six months, primary dentin; (E) Etch-and-rinse, 24 hours, permanent dentin; (F) Self-etch, 24 hours, permanent dentin; (G) Etch-and-rinse, six months, permanent dentin; (H) Self-etch, six months, permanent dentin. The MSBS was measured by a testing machine at a crosshead speed of 0.5 mm/minute. Data were analyzed using three-way analysis of variance (ANOVA). Results: The mean MSBS was 12.3±2.3 MPa in A, 18.8±4.1 MPa in B, 11.9±3.7 MPa in C, 16±2.9 MPa in D, 19.1±2.7 MPa in E, 22.8±4.1 MPa in F, 16.2±2.6 MPa in G, and 17.2±4.4 MPa in H. In the self-etch mode, the MSBS was significantly higher than that in the etch-and-rinse mode (P

The clinical effectiveness of adhesive agents has been mainly evaluated using class V restorations. Clinical studies evaluating adhesives in combination with posterior composites are scarce and of short-term periods. This paper is aimed to review the current literature on the clinical effectiveness of contemporary adhesives when used to restore posterior teeth (Class I and Class II). To conduct this review, Scopus, PubMed, and Google Scholar databases were used to search for peer-reviewed articles on the clinical performance of adhesive agents in posterior composite restorations. Search terms used included "adhesive agents," "clinical evaluation," "composite restorations," "posterior teeth," "self-etch adhesives," "etch -and -rinse adhesives," and "universal adhesives." To enrich the results, reference mining of the articles that were identified was used to locate other papers. The process of cross-referencing continued until no new articles were identified. No limits were placed on the year of publication, but only articles in English were considered. The current review found that simplification in the adhesive technique so far seems to affect the clinical performance. There is a relative paucity of evidence relating to the performance of universal adhesive agents in posterior restorations. Further long-term clinical studies are needed to evaluate the clinical performance of adhesive agents. [ABSTRACT FROM AUTHOR]

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Bonding agents are an important type of additive that are used to increase the interfacial interaction in propellants. A suitable bonding agent can prevent the dewetting between the oxidant and binder, and thus effectively improve the mechanical properties of the propellant. In the current paper, the bonding mechanisms and research progress of different types of bonding agents such as alcohol amine bonding agents, borate ester bonding agents, aziridine bonding agents, hydantoin bonding agents, neutral polymer bonding agents, and so on, are reviewed and discussed. The evaluation methods of their bonding performances including molecular dynamic simulation, contact angle method, in situ loading SEM, characterization analysis, and mechanical analysis are summarized to provide design ideas and reference for future studies.

Purpose: To evaluate the influence of different adhesive strategies (etch-and-rinse and self-etching adhesives) and type of field isolation (absolute or relative) on the clinical performance of restorations of noncervical carious lesions (NCCLs). Materials and Methods: One hundred forty NCCLs were selected from 38 patients, according to previously established inclusion/exclusion criteria, and assigned to one of four groups (n = 35): etch-and-rinse/rubber-dam (ERR), etch-and-rinse/cotton roll (ERC), self-etching/rubber-dam (SER) and self-etching/cotton roll (SEC). The adhesive systems used were: Adper Single Bond 2 (3M ESPE) and Adper SE Plus (3M ESPE), with restorations made using a composite resin (Z350, 3M ESPE). Using the USPHS modified criteria, 140 restorations were evaluated by two calibrated examiners at 5 different times: immediately after placement, at 7 days, and 2, 6, and 12 months. In order to evaluate the presence of gingival recession after the use of the #212 rubber-dam clamp, the clinical crowns of the teeth from groups ERR and SER were measured at six different periods (baseline, immediately, and at 7 days, 2, 6, and 12 months). Data were subjected to McNemar's, chi-square, and Student's t-tests. Results: Both adhesive strategies reduced tooth sensitivity beyond the second period of evaluation (7 days); tooth sensitivity disappeared after the third period of evaluation (2 months). There were no statistically significant differences between the adhesive techniques or isolation techniques, except for a Bravo score for marginal discoloration in group SEC at 6 months, which was significantly different from the other groups. The rubber-dam isolation technique was more uncomfortable for the patient and resulted in short-term gingival recession. Conclusion: No significant differences were found between the types of isolation or adhesive strategy in this clinical evaluation, with the exception of 2 restorations in group SEC that showed marginal discoloration, possibly due to inadequate enamel etching by the self-etching adhesive. Class V restorations perform equally well placed with or without rubber-dam. [ABSTRACT FROM AUTHOR]

The expanding use and enthusiasm for dental polymer aren't just ascribed to the brilliant surfaces of polymers yet besides their ideal mechanical and organic properties, minimal effort and simplicity of dealing with while preparing for a wide scope of utilizations. Polymers, for example, acrylic acid copolymers are utilized as a dental adhesive; polylactic acids are utilized for dental pulp & dentin recovery and bioactive polymers are utilized as advanced drug delivery systems. The article aims to audit the writing on the headways in the utilization of PMs in dentistry. [ABSTRACT FROM AUTHOR]

The introduction of bonding agents in restorative dentistry has made it possible to adhere restorative materials to tooth structure. Since bonded restorations were introduced by Buonocore in 1955, extensive research has been conducted to develop systems that bond equally effectively to enamel and dentin.The aim of this study was to assess the knowledge, awareness and practice about dental bonding agents in dental students. Study was conducted as a cross sectional questionnaire based study among the dental students. The study was conducted as an online survey as it is timesaving and a majority of the population can be covered. There were one hundred participants involved in this online survey from second year, third years, final years and internship. The simple random sampling was done as a sampling method. The questionnaire consisting of ten questions were posted for an online survey using google forms. The validity of the questionnaire was cross verified by experts. The data were extracted and tabulated in Microsoft Excel with respect to each question and their response. The data obtained were subjected to statistical analysis using SPSS software v20. Chi square test was done to assess the association between the variables. The descriptive data obtained were plotted in bar graphs. It was evident that interns had adequate knowledge about amalgam restorations than second years, third years and final years. [ABSTRACT FROM AUTHOR]

Bonding agents are auxiliary but critical additives in composite propellants. The bonding agent ameliorates the processing and mechanical performance of propellant through interfacial interaction between particulate fillers and binder matrix. Several bonding agents have been developed over the years to treat the dewetting problem of the composite solid propellant. In this review, we describe the different types of bonding agents, their bonding mechanism and development in the composite propellants. An individual bonding agent is discussed critically in terms of its strengths and weaknesses. The review provides an understanding of the developments of the bonding agent in the field of composite solid propellants. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the combined effect of mechanical surface treatment with intermediate bonding agents (methyl methacrylate [MMA] and silane coupling agents) and ZrO2 nanoparticle (nano‐ZrO2) addition to repair material on the shear bond strength (SBS) of repaired denture bases. Materials and Methods: Heat‐polymerized acrylic resin was used to fabricate 130 cylindrical blocks (15 mm × 10 mm) and divided into a control group without treatment (C, n = 10), and 3 repair groups (n = 40/group) divided into specimens treated with alumina blasting alone (AB), specimens blasted with alumina combined with silane coupling agent (AB + SCA), or combined with MMA‐based composite bonding agent (AB + MA). Treated groups were further subdivided according to nano‐ZrO2 concentrations into 0 wt%, 2.5 wt%, 5 wt%, and 7.5 wt% added to repair resin powder. Repair resin monomer and polymer were combined and packed on the repair area and then placed in a pressure pot at 37°C for 15 minutes for polymerization. Shear bond test was performed using a universal testing machine. Scanning electron microscopy (SEM) was used to examine the effect of surface modifications on repair surfaces and to evaluate the topography of fracture surfaces. Tukey‐Kramer multiple‐comparison test was used to detect significant differences between groups (p ≤ 0.05). Results: SBS (MPa) of specimens treated with alumina blasting and application of intermediate agents were significantly higher than the control group (p < 0.05), while no significant differences were found between AB and control group (p > 0.05). Nano‐ZrO2 addition significantly increased SBS except for AB, and 5%, 7.5% MA (p > 0.05). SEM evaluation showed that alumina blasting created rougher and more porous surfaces, while SCA and MA reduced the irregularities and fissures. Conclusion: Application of bonding agents to repair surfaces after alumina blasting improved the repair bond strength and proved to be a possible new adhesive method for denture repair. Moreover, nano‐ZrO2 addition in combination with surface treatment improved the repair bond strength. [ABSTRACT FROM AUTHOR]

Introduction: This study evaluated microleakage of flowable and conventional composite in primary molar class II restorations using self-etch and total-etch bonding agents. Methods: Class II standard cavities were prepared on proximal surface of 48 primary molars. These cavities were restored using GrandioFlow and Grandio composites and Futurabond DC and Solobond M as bonding agents. Teeth apices were sealed by wax and two-layer nail varnish was applied up to 1mm of restoration margins. Samples were subjected to thermocycling, stained by silver nitrate solution and sectioned mesiodistally. Microleakage was measured from the tooth-restoration margin to end point of dye penetration using a stereomicroscope with a 0-3 scale. Microleakage scores were analyzed using Kruskal- Wallis test in 4 groups and paired comparisons were performed using Monte Carlo test. Results: Microleakage was seen in all composite and bonding agent groups. Pairwise comparison showed no significant difference regarding the microleakage between groups (P>0.05). Conclusion: Gradioflow as a flowable composite and Futurabond DC as a self-etch bonding agent both showed acceptable results in regard to microleakage. Considering the ease of application of flowable composites compared to conventional ones and shortening the treatment both flowable composites and self-etch bonding agents have showed promising results in pediatric dentistry. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the effects of filler addition on the biaxial flexural strength and modulus of two commercial adhesive systems. Method and Materials: The systems were either unfilled (Adper Single Bond [3M ESPE] and Prime & Bond 2.1 [Dentsply]) or filled (Adper Single Bond Plus [3M ESPE] and Prime & Bond NT [Dentsply]). Resin disks of each product (0.6 mm thick and 6.2 mm in diameter) were prepared in Teflon molds (n = 11 each group; 44 in total). The adhesive solutions were light activated with a halogen light-curing unit. The disks were stored dry in the dark 24 hours before biaxial flexural testing in a universal testing machine until fracture (1.27 mm/minute; model 5844, Instron). Data were statistically analyzed by one-way ANOVA and Tukey post hoc test at a preset alpha of 0.05. Results: Flexural strength values (MPa) (SD) were Single Bond 62 (16); Single Bond Plus 46 (15); Prime & Bond 59 (13); and Prime & Bond NT 85 (16). The flexural moduli (MPa) (SD) were Single Bond 1,026 (241); Single Bond Plus 1,180 (188); Prime & Bond 744 (146); and Prime & Bond NT 1,539 (267). Based on the results, Prime & Bond NT (filled) exhibited higher flexural strength and modulus than Prime & Bond (unfilled), while no significant difference in both parameters was noted between Single Bond and Single Bond Plus. Conclusion: Filler addition to bonding agents can increase the flexural strength and modulus; however, results are product dependent. [ABSTRACT FROM AUTHOR]

Purpose: In recent years, an increase of occupational respiratory diseases, such as asthma caused by methacrylates, has been observed in dental personnel. In this study, the exposure of dental personnel to various volatile methacrylates was investigated. Materials and Methods: The air levels of methacrylates were measured during filling treatment while bonding agents were used in 4 dental practices in Munich, Germany. Short-term air sampling (15 min) was performed using solid phase microextraction (SPME). The SPME fibers were coated with carbowax/divinyl benzene to enrich the analytes. For analysis, the analytes were thermically desorbed from the fiber and subsequently analyzed directly by gas chromatography/ mass spectrometry. Results: The methacrylates methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and triethylene glycol dimethacrylate (TEG-DMA) were identified in the air of dental practices. The exposure levels of the four methacrylates varied during the filling treatments. The maximum concentrations found were 0.4 mg/m3 for MMA, 45 μg/m3 for HEMA, 13 μg/m3 for EGDMA, and 45 μg/m3 for TEG-DMA. The detection of TEG-DMA correlated with the application of bonding agents during performance of dental fillings. Conclusion: Exposure levels of different methacrylates were observed at all investigated dental practices. The maximum levels of MMA measured in this study were at least 200 times lower than the toxicologically relevant maximum allowable concentrations defined in various countries. Nevertheless, the exposure levels of methacrylates should be kept as low as possible due to the allergenic potential of some methacrylates. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the effect of different surface treatments on the tensile bond strength (TBS) of immediately repaired anterior microfine hybrid restorative composite using nontrimmed hourglass-shaped specimens. Materials and Methods: Fifty-six nontrimmed hourglass composite specimens were prepared in this study. Eight specimens were used for the evaluation of the cohesive tensile strength as the control group. The remaining 48 were divided into 6 equal groups according to the method of proposed treatment. Groups IM1 and IM2: The specimens were repaired without intermediate treatment. Group IM3: A thin layer of Excite self-priming adhesive was applied to the proposed repaired area of each half-specimen. Group IM4: The repaired area was ground using an abrasive stone, each half-specimen was rinsed and dried, and the adhesive applied. Group IM5: Treatment consisted of 37% phosphoric acid etching of the proposed repair area. The adhesive was then applied. Group IM6: The repaired area was ground and acid etched before applying the adhesive. In all repaired groups except for IM2, repaired specimens were prepared and cured against a single layer of transparent polyester strip (matrix) to prevent the formation of an oxygen inhibition layer. In group IM2, specimens were cured in air without the polyester strip. Specimens were then tested for the repair tensile bond strength (TBS) in a universal testing machine at a crosshead speed of 0.5 mm/min until failure. Twelve more samples were used for SEM characterization of nontreated, ground, acid-etched, and ground/acid-etched samples. The failure mode was evaluated using a stereomicroscope at 30X magnification. All TBS data were expressed as mean and standard deviation, and were analyzed using StatsDirect 2.5.7. One-way ANOVA followed by Tukey-Kramer multiple-comparison post-hoc tests were used to compare the TBS between all tested groups. Differences were considered significant at p < 0.05. Results: Groups that were cured against a matrix and received no treatment or were repaired with adhesive only had significantly lower TBS than the control group. Groups which were cured without the matrix and received no treatment or grinding/adhesive, acid etching/adhesive, and grinding/acid etching/adhesive showed no significant difference in TBS compared to the control group. SEM evaluation showed that acid etching did not change the morphology of the composite surface. The ground specimens showed a grooved pattern with smeared grinding products. Ground/acid-etched specimens showed removal of the smeared products with a less distinct grinding-groove pattern. Stereomicroscopic evaluation of the debonded surfaces for all repaired groups showed that the failure mode was predominantly adhesive for all evaluated debonded surfaces in each repair group. Conclusion: In the absence of an oxygen inhibition layer, the immediate repair bond strength was decreased. In contrast, in the presence of an oxygen inhibition layer, the immediate repair bond strength of composite was improved. The application of a thin adhesive layer did not improve the immediate repair bond strength as the other surface treatments did. When the composite was cured against a matrix, chemical and/or mechanical treatments of composite surface prior to application of the adhesive proved to be an effective method to improve the immediate repair bond strength. [ABSTRACT FROM AUTHOR]

Objectives: To compare the cytotoxicity of the polymerized bonding agents Scotchbond 1 (3M ESPE), Prime & Bond NT (Dentsply DeTrey), Xeno III (Dentsply DeTrey), and Clearfil Protect Bond (primer and bond parts; Kuraray) on mouse fibroblast cells. Xeno III was also tested through thin dentin disks. Method and Materials: Near-confluent 3T3 cells were exposed to Dulbecco modified eagle's medium extractions from the above-mentioned agents, and the cell viability (survival rate) was measured using the standard MTT assay and related to the nonexposed controls. Results: All bonding agents were found to be cytotoxic toward the 3T3 cells. Scotchbond 1 (59% survival rate) and Prime & Bond NT (62% survival rate) were not statistically different (Kruskal-Wallis test, P > .05). However, the survival rates of Xeno III (25% through membrane and dentin disks) and Clearfil Protect Bond (35%) were significantly lower than those of the other 2 bonding agents, with Xeno III significantly the most toxic (Kruskal-Wallis test, P < .05). Of the 2 parts from Clearfil Protect Bond, the bond part was the least toxic (91% survival rate), but the primer part was very toxic (30% survival rate). Conclusion: In an in vitro culture, all 4 dentin bonding agents were cytotoxic. Xeno III was the most toxic, even through dentin disks. It seems that the cytotoxicities depend on the compositions of the materials tested. The most toxic part of Clearfil Protect Bond was the primer, which contains the antibacterial pyridinium molecule. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate and compare shear bond strength of 3 self-etching bonding agents to enamel and dentin when the bonding agent is light cured before the application of resin composite or co-cured together with the resin composite. Method and Materials: One hundred twenty extracted teeth were wet ground to create a flat bonding area on enamel and dentin. Three bonding agents (Adper Prompt-L-Pop, Clearfil SE Bond, and Xeno III) were applied to either dentin or enamel according to the manufacturers' directions. In half of the specimens, bonding agents were light cured immediately after their application (Group PRC). The other half were not light cured until resin composite application (Group COC). Resin composite was placed into a Teflon tube and light cured over the adhesive. Specimens were stored in deionized water for 24 hours at room temperature before being loaded in shear until failure with an Instron testing machine. Shear bond strength (in megapascals) was analyzed with 2-factor ANOVA, separate single-factor ANOVA models for cure and material, and Tukey's Honestly Significant Differences multiple comparison procedure. All testing was performed at the 5% significance level (n=10). Results: Light-curing the adhesive separately produced significantly higher bond strengths to dentin (P < .001) than did the co-cure method. Group FAG did not produce significantly different bond strengths to enamel (P = .420). Conclusions: Pre-curing of self-etching adhesives before curing of the resin composite produces greater bond strength to dentin. The curing technique has no significant effect on enamel bond strength of self-etching adhesives. [ABSTRACT FROM AUTHOR]

Objectives: The objective of this study was to assess the effect of a one-bottle bonding agent on sealant success after 3, 6, 12, and 24 months. Method and materials: The sample group consisted of 30 schoolchildren (8 to 10 years of age) who had all their permanent first molars sound and unsealed. Occlusal sealants were placed on first molars according to a split-mouth design. Sealant scoring occurred at 3, 6, 12, and 24 months and was performed by two clinicians blinded to the treatment group. Fisher's exact test was used to analyze the data. Results: The clinically acceptable marginal integrity rates for sealants with a bonding agent after 3, 6, 12, and 24 months were 93%, 93%, 83%, and 79%, respectively For sealants without a bonding agent, the clinically acceptable marginal integrity rates after 3, 6, 12, and 24 months were 90%, 88%, 81%, and 77%. The rates for no color change in sealants with a bonding agent after 3, 6, 12, and 24 months were 96%, 93%, 81%, and 75%, respectively. For sealants without a bonding agent, the no color change rates after 3, 6, 12, and 24 months were 93%, 93%, 79%, and 72%. After 24 months, 73% of the sample group were available for recall. The retention rates for sealants with and without a bonding agent after 24 months were 79% and 75%, respectively The results of the statistical analysis showed that there were no differences among the sealants with and without bonding agents evaluated in relation to marginal integrity, marginal discoloration, and anatomic form. Conclusion: The success of a sealant is related to whether the sealant is applied under optimal conditions. The results of this study show that at the 2-year mark, the placement of a bonding agent under sealants did not significantly affect the clinical success of sealants. [ABSTRACT FROM AUTHOR]

Objective: Microorganisms are directly associated with the etiotogy of enamel, dentin, and pulpal pathology. Due to the growing usage of one-bottle bonding materials with resin composite restorations, as well as sealing agents with amalgam restorations, it is important that they possess antibacterial properties. In the present study, the antibacterial properties of polymerized one-bottle bonding agents were tested, using the direct contact test (DCT) and the agar diffusion test (ADT). Method and materials: Quadruple samples of the following materials were tested in both assays: Bond-1, OptiBond Solo, One-Step, Gluma, Prime & Bond NT, and Synergy. In the DCT, samples were placed on the sidewalls of wells of a 96-microtiter plate and polymerized A10-uL suspension of Streptococcus mutans was placed on the surface of each sample for 1 hour at 37°C. Fresh media was then added, and bacterial growth was followed with a temperature-controlled spectrophotometer. In the ADT, samples were placed in punched wells of inoculated agar plates, and halos In the bacterial lawn were measured after 72 hours. Results: In the DCT, all the tested bonding agents exhibited potent antibacterial properties; virtually no viable bacteria were present in any of the samples. When the samples were aged in phosphate-buffered saline for 24 hours, all the tested agents, similar to the freshly polymerized samples, exhibited potent antibacterial properties. This properly was lost in samples aged for 7 days. Fresh samples assayed by ADT demonstrated no inhibition halo around any of the samples. Conclusion: Collectively, the present data suggest that one-bottle bonding agents possess in vitro antibacterial properties for at least 24 hours. This phenomenon was demonstrated only by DCT. (Quintessence Irrt 2004:35275-279) [ABSTRACT FROM AUTHOR]

BACKGROUND AND OBJECTIVE: The matrix metalloproteinase plays a significant role in the bonding stability of the composite-tooth. Chlorhexidine has been offered as matrix metalloproteinase inhibitor in current years. The aim of this study was to investigation of effect of 2% chlorhexidine on enamel microleakage of composite fillings in different bonding systems. METHODS: In this in vitro study, class V cavities were prepared on the lingual and buccal surface of forty extracted molar teeth. The cavities were etched and divided randomly to 8 groups: 1: Adper single Bond 2 (ASB), 2: Clearfil SE Bond (CSE), 3: Clearfil S3 Bond (CS3), 4: Single Bond Universal (SBU), 5: ASB + 2% Chlorhexidine (CHX), 6: CSE +2%CHX, 7: CS3 +2% CHX, 8: SBU + 2%CHX. After bonding application, the cavities were restored with Z250 composite and thermocycling procedure (5 to 55 C, 5000 cycles) was done. Enamel microleakage was measured by dye penetration test. The teeth were sectioned buccolingually and microleakage was recorded based on a 0‒3 scoring system under a stereomicroscope (Motic Micro Optic, industrial group Co, LTD, Japan) at 40x magnification. Data analysis was done. FINDINGS: In ASB, CSE, CS3 and SBU bonding systems, Percent of samples without microleakage before use CHX was 80%, 90%, 90%and 80% and after it was 100%, 80%, 80% and 90 % respectively. CONCLUSION: Use of 2% chlorhexidine has not adverse effect on enamel microleakage of composite restorations in different bonding systems.

Objective: The aim of this study was to evaluate the shear bond strength of universal adhesives applied with self-etch and etch&rinse techniques to dentin. Materials and Method: Fourty-eight sound extracted human third molars were used in this study. Occlusal enamel was removed in order to expose the dentinal surface, and the surface was flattened. Specimens were randomly divided into four groups and were sectioned vestibulo-lingually using a diamond disc. The universal adhesives: All Bond Universal (Group 1a and 1b), Gluma Bond Universal (Group 2a and 2b) and Single Bond Universal (Group 3a and 3b) were applied onto the tooth specimens either with self-etch technique (a) or with etch&rinse technique (b) according to the manufacturers’ instructions. Clearfil SE Bond (Group 4a; self-etch) and Optibond FL (Group 4b; etch&rinse) were used as control groups. Then the specimens were restored with a nanohybrid composite resin (Filtek Z550). After thermocycling, shear bond strength test was performed with a universal test machine at a crosshead speed of 0.5 mm/min. Fracture analysis was done under a stereomicroscope (×40 magnification). Data were analyzed using two-way ANOVA and post-hoc Tukey tests. Results: Statistical analysis showed significant differences in shear bond strength values between the universal adhesives (p

Objective: The aim of this study was to evaluate the push-out bond strength of fiber posts used in the restoration of endodontically-treated teeth with extreme material loss, luted with two different self-adhesive resin cements alone or with the combination of an adhesive. Materials and Method: The post spaces of 80 extracted mandibular first premolar roots were prepared and divided into 4 experimental groups according to fiber post (RelyX Fiber Post) luting material. Group 1 was luted with RelyX Unicem, Group 2 was luted with RelyX Unicem + Adper Easy One, Group 3 was luted with Clearfil SA Cement, and Group 4 was luted with Clearfil SA Cement + S3 Bond. After 24 h and 1 month, horizontal sections of 1 mm thickness were made from the coronal, middle and apical root parts of the fiber posts, and push-out tests were performed. Groups were compared by using one way analysis of variance (ANOVA) and Tukey’s HSD post hoc tests and storage periods were compared by using independent samples t-test (α=0.05). Results: For both evaluation time periods, RelyX Unicem + Adper Easy One showed the highest bond strength. Regarding the 24 h period, the lowest bond strength values were found for the apical sections followed by middle and coronal sections. One month results revealed similar bond strength values for the middle and apical sections (p>0.05) which were significantly lower than the values found for the coronal sections (p

Introduction: Dental caries is one of the most common preventable childhood infections. a number of measures are available to prevent occlusal caries; pit and fissure sealants are one of the various methods currently available to cost effectively reduce dental caries. Aim: To evaluate the retention of pit and fissure sealant bonded using sixth (Adper promt), seventh (Optibond) and eighth (Futurabond Dual Cure) generations of adhesives. Settings and Design: A total of 37 healthy children who fulfilled the inclusion were randomly selected. A total of 148 teeth (4 in each subject) were used as samples for the study. Methods and Material: The teeth to be sealed were then isolated using rubber dam. The placement of adhesives was done using split mouth design. The first permanent molars were randomly divided into four groups on the basis of sealant placed without and with using 6th, 7th and 8th generation bonding agents as follows: GROUP A (N=37):- Pit and fissure sealant placed without bonding agent. GROUP B (N=37):- Pit and fissure sealant placed following sixth generation bonding agent (ADPER PROMT). GROUP C (N=37):- Pit and fissure sealant placed following seventh generation bonding agent. (OPTIBOND). GROUP D (N=37):- Pit and fissure sealant placed following eighth generation bonding agent. (FUTURA BOND DUAL CURE). The integrity of the sealant placed was assessed immediately after completion of the procedure, 3 months and 6 months after placement. The post-operative evaluation for retention was done using Simonsen criteria. A score of 0 was given for complete retention, 1 for partial retention and 2 for no retention. Statistical analysis used: The statistical analysis was done using SPSS (Statistical Package for Social Sciences) software version 21. Results: It was found that there was no statistically significant difference between the groups after 3 and 6 months as the value obtained (0.133) was much greater than the p-value (0.05). Conclusions: This study concluded that the use of bonding agent prior to application of pit and fissure sealant does not necessarily aid in retention of sealant as compared to pit and fissure sealant placed without bonding agent, Sealants effectiveness is directly related to its retention and it dependent on application procedures. The failure of retention of pit and fissure sealants can attribute to moisture contamination, improper curing methods, inadequate adhesion, improper application procedure or early age placement.

Background and Aims: Microleakage is one of the most common problems in bonding systems, which cause different clinical shortcomings such as post operative sensitivity, marginal discoloration and pulp necrosis that can decrease those using bonding systems. The aim of this study was to compare the microleakage of three self etch bonding agents (generation 6 and 7) in class 5 composite cavities. Materials and Methods: In this experimental study, 30 facial class 5 cavities were prepared in 30 human premolar teeth which were freshly extracted for orthodontic purposes. Cl V cavities were prepared in 2*3*2 mm dimensions. Occlusal margins were in enamel and gingival ones in cementum and randomly divided into 3 groups of 10 each. Then the cavities were treated by clearhil SE Bond (Kuraray, Japan), G Bond (GC, Japan), and Opti Bond Solo Plus (Kerr, USA), according to the manufacturers’ insductions. Then the cavities were filled using Z100 resin composite. The specimens were then immersed in a 50% AgNo solution for 24 hrs. Then, the teeth were cut buccolingually to be evaluated for dye penetration with stereomicroscope. Data were analyzed using Kruskal-Wallis test. Results: This study revealed that Opti bond solo plus had type1 microleakage (dye penetration up to 1/3 of cavity) in 80% of specimen, and type 4 microleakage (along axial wall) in 10%. Clearfil SE bond had no leakage in 50%, type1 in 40% and type 2 (up to 2/3 of cavity) in 10%. But there was no significant difference in the microleakage at the gingival margins between 3 groups (P>0.05). Conclusion: Clearfil SE Bond and G bond could prevent microleakage more effectively than that of Opti Bond Solo Plus on the occlusal margins. However, no difference in the microleakage on the gingival surfaces was found.