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The objective: to analyze the experience of using hyperthermic intravesical chemotherapy (HIVEC) with Mitomycin-C (MMC) and the addition of dimethyl sulfoxide (DMSO) in high-risk of non-muscle-invasive bladder cancer (HR NMIBC) patients and to compare oncological results with BCG therapy. Materials and methods. From March 2018 to January 2021, 53 patients with high-risk of NMIBC underwent a HIVEC adjuvant regimen at the University Clinic of Odessa National Medical University. The results were compared with a group of patients who received adjuvant intravesical BCG therapy from 2015 to 2019. In the HIVEC group, 16 (30.2%) patients with reduced bladder capacity underwent a session of the HIVEC therapy with prior injection of DMSO solution into the bladder. The primary endpoint was recurrence-free survival (RFS). Secondary endpoints were time to recurrence, progression-free survival (PFS), cancer-specific survival and overall survival at 36 months. Results. The incidence of the disease recurrence (42.6% vs 22.6%; p=0.028) and progression (20.4% vs 7.5%; p=0.50) were different between the BCG and HIVEC, respectively. The mean time to recurrence in patients who received HIVEC MMC was significantly higher than in patients of the BCG group: 31.5 months (95% CI: 29.1-34.0) versus 26.0 months (95% CI: 22.7-29.3), respectively (p=0.034). Cox regression analysis showed that the hazard ratio for HIVEC vs BCG for the RFS at 36 months was 0.48 (95% CI: 0.24-0.96; p=0.04). The RFS and the PFS indicators during the 36-month follow-up period in patients who received additional intravesical DMSO administration were not significantly different from other patients in the HIVEC therapy group. Conclusions. Hyperthermic intravesical chemotherapy with the addition of DMSO is a safe treatment option for patients with high-risk of noninvasive bladder cancer with efficacy comparable to BCG therapy. [ABSTRACT FROM AUTHOR]

Currently, the search for additional organ-sparing methods of intravesical therapy for non-muscular-invasive bladder cancer (NMIBC) is actively continuing, which could become an effective alternative to standard treatment using the Bacillus Calmette-Guérin (BCG) vaccine. The aim of this work was to analyze the safety profile and long-term results of treatment of patients with the high-risk non-muscular-invasive bladder cancer who received adjuvant intravesical chemotherapy using the Combat BRS HIVEC® device for local hyperthermia (HIVEC® therapy group; n=53) in comparison with patients who received adjuvant therapy after transurethral resection of bladder performed with the Bacillus Calmette-Guérin vaccine (BCG therapy group; n=54). As a result, the median follow-up was 30 months (range 7-36). According to Common Terminology Criteria for Adverse Events (CTCAE) v 5.0, the most relevant side effects in HIVEC®/BCG therapy groups were adverse events grade 1-2: fever – 1%/8%; dysuria – 9%/13%; bladder spasms – 7%/12%; hematuria – 3%/4% and urinary tract infection – 3%/10%. Tumor recurrence was reported in 23 patients receiving intravesical BCG therapy and in 10 patients receiving intravesical hyperthermic chemotherapy (42.6% versus 18.9%, p=0.008). Tumor progression was recorded in 11 patients receiving intravesical BCG therapy and in 4 patients receiving intravesical hyperthermic chemotherapy (20.4% versus 7.5%, p=0.046). The study allows us to conclude that the method of hyperthermic intravesical chemotherapy has a better safety profile compared to intravesical Bacillus Calmette–Guérin vaccine therapy, while such indicators of oncological efficacy as 3-year recurrence-free survival and the incidence of progression were better in the HIVEC® therapy group [ABSTRACT FROM AUTHOR]

Temperature-dependent magnetic properties and spin echo decay behavior have been studied for an ensemble of La1−xSrxMnO3 (x = 0.23) nanoparticles (of 30 nm in diameter) synthesized by the sol–gel method. Characteristic magnetic parameters, such as blocking temperature and effective Curie temperature for the ensemble, are determined. Enhanced coercivity and its unusual temperature dependence compared to bulk counterparts are revealed, and possible reasons for this phenomenon are discussed. A conclusion about the non-negligible role of interparticle interactions in the enhancement of the coercivity in the ensembles of substituted manganites is made. [ABSTRACT FROM AUTHOR]

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