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31 results on '"Bonato, Raffaele"'

1. Routine Adoption of Urinary [IGFBP7]∙[TIMP-2] to Assess Acute Kidney Injury at Any Stage 12 hours After Intensive Care Unit Admission: a Prospective Cohort Study

Author

Ferrari, Fiorenza, Romero-González, Gregorio, Topete, Lilia Rizo, Senzolo, Mara, Lorenzin, Anna, Husain-Syed, Faeq, Puci, Mariangela Valentina, Ferraro, Ottavia Eleonora, Muraro, Eva, Serrano-Soto, Mara, Triviño, Alejandra Molano, Castro, Ana Coutinho, Xie, Yun, Yang, Bo, De Cal, Massimo, Corradi, Valentina, Brendolan, Alessandra, Scarpa, Marta, Carta, Maria Rosa, Giavarina, Davide, Bonato, Raffaele, and Ronco, Claudio

Published
2019
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3. Development of the New Kibou® Equipment for Continuous Renal Replacement Therapy from Scratch to the Final Configuration

Author

Neri, Mauro, primary, Lorenzin, Anna, additional, Brendolan, Alessandra, additional, Garzotto, Francesco, additional, Ferrari, Fiorenza, additional, De Rosa, Silvia, additional, Bonato, Raffaele, additional, Villa, Gianluca, additional, Bazzano, Simona, additional, D''Ippoliti, Fiorella, additional, Ricci, Zaccaria, additional, La Manna, Gaetano, additional, and Ronco, Claudio, additional

Published
2017
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6. Influence of patients’ clinical features at intensive care unit admission on performance of cell cycle arrest biomarkers in predicting acute kidney injury

Author

Yang, Bo, primary, Xie, Yun, additional, Garzotto, Francesco, additional, Ankawi, Ghada, additional, Passannante, Alberto, additional, Brendolan, Alessandra, additional, Bonato, Raffaele, additional, Carta, Mariarosa, additional, Giavarina, Davide, additional, Vidal, Enrico, additional, Gregori, Dario, additional, and Ronco, Claudio, additional

Published
2020
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12. Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit

Author

Ferrari, Fiorenza, primary, Puci, Mariangela Valentina, additional, Ferraro, Ottavia Eleonora, additional, Romero-González, Gregorio, additional, Husain-Syed, Faeq, additional, Rizo-Topete, Lilia, additional, Senzolo, Mara, additional, Lorenzin, Anna, additional, Muraro, Eva, additional, Baracca, Antonio, additional, Serrano-Soto, Mara, additional, Molano Triviño, Alejandra, additional, Coutinho Castro, Ana, additional, De Cal, Massimo, additional, Corradi, Valentina, additional, Brendolan, Alessandra, additional, Scarpa, Marta, additional, Carta, Maria Rosa, additional, Giavarina, Davide, additional, Bonato, Raffaele, additional, Iotti, Giorgio Antonio, additional, and Ronco, Claudio, additional

Published
2019
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13. Influence of patients' clinical features at intensive care unit admission on performance of cell cycle arrest biomarkers in predicting acute kidney injury.

Author

Yang, Bo, Xie, Yun, Garzotto, Francesco, Ankawi, Ghada, Passannante, Alberto, Brendolan, Alessandra, Bonato, Raffaele, Carta, Mariarosa, Giavarina, Davide, Vidal, Enrico, Gregori, Dario, and Ronco, Claudio

Subjects
INSULIN-like growth factor-binding proteins, ACUTE kidney failure, INTENSIVE care units, CELL cycle, RECEIVER operating characteristic curves
Abstract

Objectives: Identification of acute kidney injury (AKI) can be challenging in patients with a variety of clinical features at intensive care unit (ICU) admission, and the capacity of biomarkers in this subpopulation has been poorly studied. In our study we examined the influence that patients' clinical features at ICU admission have over the predicting ability of the combination of urinary tissue inhibitor of metalloproteinase-2 (TIMP2) and insulin-like growth factor binding protein 7 (IGFBP7). Methods: Urinary [TIMP2]•[IGFBP7] were measured for all patients upon admission to ICU. We calculated the receiver operating characteristics (ROC) curves for AKI prediction in the overall cohort and for subgroups of patients according to etiology of ICU admission, which included: sepsis, trauma, neurological conditions, cardiovascular diseases, respiratory diseases, and non-classifiable causes. Results: In the overall cohort of 719 patients, 239 (33.2%) developed AKI in the first seven days. [TIMP2]•[IGFBP7] at ICU admission were significantly higher in AKI patients than in non-AKI patients. This is true not only for the overall cohort but also in the other subgroups. The area under the ROC curve (AUC) for [TIMP2]•[IGFBP7] in predicting AKI in the first seven days was 0.633 (95% CI 0.588–0.678), for the overall cohort, with sensitivity and specificity of 66.1 and 51.9% respectively. When we considered patients with combined sepsis, trauma, and respiratory disease we found a higher AUC than patients without these conditions (0.711 vs. 0.575; p=0.002). Conclusions: The accuracy of [TIMP2]•[IGFBP7] in predicting the risk of AKI in the first seven days after ICU admission has significant variability when the reason for ICU admission is considered. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Predicting Acute Kidney Injury in Intensive Care Unit Patients: The Role of Tissue Inhibitor of Metalloproteinases-2 and Insulin-Like Growth Factor-Binding Protein-7 Biomarkers

Author

Di Leo, Laura, primary, Nalesso, Federico, additional, Garzotto, Francesco, additional, Xie, Yun, additional, Yang, Bo, additional, Virzì, Grazia Maria, additional, Passannante, Alberto, additional, Bonato, Raffaele, additional, Carta, Mariarosa, additional, Giavarina, Davide, additional, Gregori, Dario, additional, Brendolan, Alessandra, additional, Ferrari, Fiorenza, additional, and Ronco, Claudio, additional

Published
2018
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16. The effect of whole-body cooling on renal function in post-cardiac arrest patients

Author

De Rosa, Silvia, primary, De Cal, Massimo, additional, Joannidis, Michael, additional, Villa, Gianluca, additional, Pacheco, Jose Luis Salas, additional, Virzì, Grazia Maria, additional, Samoni, Sara, additional, D’ippoliti, Fiorella, additional, Marcante, Stefano, additional, Visconti, Federico, additional, Lampariello, Antonella, additional, Zannato, Marina, additional, Marafon, Silvio, additional, Bonato, Raffaele, additional, and Ronco, Claudio, additional

Published
2017
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17. Routine Adoption of TIMP2 and IGFBP7 Biomarkers in Cardiac Surgery for Early Identification of Acute Kidney Injury

Author

Levante, Chiara, primary, Ferrari, Fiorenza, additional, Manenti, Chiara, additional, Husain-Syed, Faeq, additional, Scarpa, Marta, additional, Danesi, Tommaso Hinna, additional, De Cal, Massimo, additional, Corradi, Valentina, additional, Virzì, Grazia M., additional, Brendolan, Alessandra, additional, Nalesso, Federico, additional, Bezerra, Pércia, additional, Lopez-Giacoman, Salvador, additional, Samoni, Sara, additional, Senzolo, Mara, additional, Giavarina, Davide, additional, Salvador, Loris, additional, Bonato, Raffaele, additional, De Rosa, Silvia, additional, Rettore, Enrico, additional, and Ronco, Claudio, additional

Published
2017
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18. Non-Hepatic Hyperammonemia: A Case Report

Author

De Rosa, Silvia, Ferrari, Fiorenza, Sartori, Marco, Samoni, Sara, Rigobello, Alessandro, Mozzo, Nives, Carrada, Alessandra, Fornasier, Luana, Marafon, Silvio, and Bonato, Raffaele

Published
2015

19. Impact of hyperhydration on the mortality risk in critically ill patients admitted in intensive care units: comparison between bioelectrical impedance vector analysis and cumulative fluid balance recording

Author

Samoni, Sara, primary, Vigo, Valentina, additional, Bonilla Reséndiz, Luis Ignacio, additional, Villa, Gianluca, additional, De Rosa, Silvia, additional, Nalesso, Federico, additional, Ferrari, Fiorenza, additional, Meola, Mario, additional, Brendolan, Alessandra, additional, Malacarne, Paolo, additional, Forfori, Francesco, additional, Bonato, Raffaele, additional, Donadio, Carlo, additional, and Ronco, Claudio, additional

Published
2016
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28. Four-side near-infrared spectroscopy measured in a paediatric population during surgery for congenital heart disease.

Author

Amigoni, Angela, Mozzo, Elena, Brugnaro, Luca, Tiberio, Ivo, Pittarello, Demetrio, Stellin, Giovanni, and Bonato, Raffaele

Abstract

In this study we monitored renal, hepatic and muscular oxygen saturations by near-infrared spectroscopy and we evaluated the correlation with variables that could affect tissue oxygenation in 16 paediatric patients during surgical heart procedure. We considered the following phases: 1) basal time (after induction of anaesthesia and before median sternotomy), 2) before starting cardiopulmonary bypass, 3) 15 min after starting it, 4) at half time, 5) 15 min before the end, 6) at the end, 7) 15 min after the end, and 8) 10 min before paediatric intensive care unit admission. Heart rate, mean arterial pressure, peripheral oxygen saturation, serum lactate, haemoglobin, blood gas analysis, and rectal temperature were registered. We found a decrease of all monitored regional saturations (rSO(2)) (cerebral P = 0.006, hepatic P = 0.005) before starting the bypass. After this time, cerebral saturation gradually increased without reaching the basal value; renal and liver saturations increased after starting bypass; muscular rSO(2) increased in the second half (P = 0.005). A statistically significative inverse correlation between cerebral rSO(2) and pH was observed. In conclusion, during paediatric heart surgery a vulnerable period was identified. We underline the necessity to monitor this phase.

Published
2011
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29. Tissue inhibitor metalloproteinase-2 (TIMP-2) • IGF-binding protein-7 (IGFBP7) levels are associated with adverse outcomes in patients in the intensive care unit with acute kidney injury

Author

Kumar Digvijay, Claudio Ronco, Andrea Breglia, Francesco Garzotto, Dario Gregori, Alessandra Brendolan, Ghada Ankawi, Bonato Raffaele, Fiorenza Ferrari, Alberto Passannante, Bo Yang, Yun Xie, and Davide Giavarina

Subjects
0301 basic medicine, Male, medicine.medical_treatment, 030232 urology & nephrology, Kaplan-Meier Estimate, urologic and male genital diseases, outcomes, Gastroenterology, intensive care unit, Severity of Illness Index, Procalcitonin, law.invention, 0302 clinical medicine, law, Hospital Mortality, Prospective Studies, Aged, 80 and over, Kidney, Incidence (epidemiology), Acute kidney injury, Acute Kidney Injury, Middle Aged, Prognosis, Intensive care unit, female genital diseases and pregnancy complications, Insulin-Like Growth Factor Binding Proteins, Renal Replacement Therapy, Intensive Care Units, medicine.anatomical_structure, Italy, Nephrology, Female, Cohort study, medicine.medical_specialty, Risk Assessment, 03 medical and health sciences, TIMP-2, Predictive Value of Tests, Internal medicine, medicine, Humans, Renal replacement therapy, Aged, Tissue Inhibitor of Metalloproteinase-2, business.industry, medicine.disease, 030104 developmental biology, ROC Curve, IGFBP7, Feasibility Studies, acute kidney injury, business, Biomarkers, Kidney disease
Abstract

The G1 cell cycle inhibitors tissue inhibitor metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been identified as novel biomarkers for the prediction of moderate to severe acute kidney injury (AKI) risk. However, the prognostic value of [TIMP-2]•[IGFBP7] in predicting adverse outcomes in intensive care unit (ICU) patients with AKI was not previously described. To evaluate this, we conducted a cohort study, measuring [TIMP2]•[IGFBP7] levels in critically ill patients admitted to the ICU and classified the patients as NephroCheck (NC) (+) or NC (-) according to [TIMP-2]•[IGFBP7] values and AKI (+) or AKI (-) according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We then evaluated the incidence of continuous renal replacement therapy initiation, all-cause mortality and a composite endpoint of both in the four groups. Baseline [TIMP-2]•[IGFBP7] values were available for 719 patients, of whom 239 developed AKI and 151 met the composite endpoint. Compared to NC (-)/AKI (+) patients, NC (+)/AKI (+) patients had a significant risk of ICU mortality and the composite endpoint. Kaplan-Meier curves showed that the survival estimate for the composite endpoint of NC (+)/AKI (+) patients was 34.4%; significantly worse than NC (-)/AKI (+) patients (67.4%). Multivariate analyses showed strong association between NC positivity and the composite endpoint. The inflammatory marker, procalcitonin, was an additional prognostic biomarker to compare and confirm the incremental value of NephroCheck. No association between procalcitonin and the composite endpoint was found, especially in patients with AKI, suggesting that NephroCheck may be more kidney specific. Thus, the [TIMP-2]•[IGFBP7] values can serve to identify patients with AKI at increased risk for adverse outcomes in the ICU.

30. [The validation of C-POT (Critical-Care Pain Observation Tool) scale: a tool for assessing pain in intensive care patients].

Author

Stefani F, Nardon G, Bonato R, Modenese A, Novello C, and Ferrari R

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Feasibility Studies, Female, Humans, Intensive Care Units, Italy, Male, Middle Aged, Pain diagnosis, Pain Measurement methods, Pain Threshold, Reproducibility of Results, Retrospective Studies, Surveys and Questionnaires, Critical Care methods, Nursing Assessment methods, Pain nursing, Pain Measurement nursing, Psychometrics
Abstract

Unlabelled: Pain in intensive care units is a frequent and often undermanaged problem, mainly because appropriate pain assessment tools for non communicative patients are still missing. The Critical-Care Pain Observation Tool (C-POT) is currently considered one of the best scales, both for psychometric properties and clinical feasibility., Aim: To preliminarily analyze the reliability and validity of the C-POT in a hospital setting, and its clinical feasibility., Methods: 50 nursing staff members from three different critical care settings of Vicenza Hospital administered the C-POT to 121 in patients, at rest and after usual nursing care activities. In addition, NOPPAIN forms were completed during care activities and communicative patients were asked to rate their pain using numerical rating scale 0-10. Reliability, with Cronbach's alfa and inter-rater agreement (Spearman's non parametric rank correlation), as well as criterion, concurrent and discriminant validity were determined., Results: A good internal consistency and good levels of agreement between independent raters were observed (ρSpearman 0.55 at rest and 0.66 during activity). Moderate correlations between C-POT and numerical rating scale 0-10, and between C-POT and NOPPAIN were found. Moreover, C-POT scores varied from rest to activities, and from non painful to painful procedures., Discussion: C-POT showed good psychometric properties in terms of reliability and validity; these results, added to positive nurses evaluations, support its utility and use in the clinical setting.

Published
2011
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31. Interventional approach to reduce thromboembolic risk in patients with atrial fibrillation ineligible for oral anticoagulation.

Author

Ramondo A, Maiolino G, Napodano M, Isabella G, Tarantini G, Bonato R, Pengo V, Ponchia A, and Iliceto S

Subjects
Administration, Oral, Aged, Anticoagulants administration & dosage, Anticoagulants adverse effects, Balloon Occlusion methods, Cardiac Catheterization methods, Contraindications, Humans, Male, Risk Factors, Atrial Appendage physiopathology, Atrial Fibrillation therapy, Balloon Occlusion instrumentation, Cardiac Catheterization instrumentation, Thromboembolism prevention & control
Abstract

The annual incidence of stroke in patients with nonrheumatic atrial fibrillation averages 5% per year and increases with age, left ventricular dysfunction, hypertension, diabetes or prior stroke. Since in nonrheumatic atrial fibrillation 91% of left atrial thrombi are located in the left atrial appendage, in patients ineligible for oral anticoagulation it was suggested the percutaneous closure of left atrial appendage as a therapeutic option to reduce embolic risk. In this article we report our initial experience with this procedure, which was uneventful and efficacious at short-term follow-up. In conclusion, the interventional approach in patients with atrial fibrillation ineligible for oral anticoagulation seems feasible and promising, and deserves further investigation.

Published
2005

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