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"Love and Despair: How Catholic Activism Shaped Politics and the Counterculture in Modern Mexico" by Jaime M. Pensado explores the impact of Mexican Catholics on local, regional, and global changes during the Cold War era. The book highlights the activism of conservative and progressive Catholics, including students, intellectuals, filmmakers, journalists, and priests, who embraced a language of "love" to promote social justice and inclusivity. The author argues that Mexican Catholics adopted both conservative and liberal discourses, becoming radicalized by the progressive turn within global Catholicism and the revolutionary upheaval of the 1960s. The book also examines the rise of progressive Catholicism, the changing political context of Mexico in the 1960s, and the interaction of Mexican Catholics with the counterculture movement known as "La Onda." Overall, "Love and Despair" provides a nuanced understanding of how Mexican society engaged with modernity during the Cold War, emphasizing the diverse and multifaceted nature of Catholicism in Mexico. [Extracted from the article]

Background. Identifying youth who may engage in future substance use could facilitate early identification of substance use disorder vulnerability. We aimed to identify biomarkers that predicted future substance use in psychiatrically unwell youth. Method. LASSO regression for variable selection was used to predict substance use 24.3 months after neuroimaging assessment in 73 behaviorally and emotionally dysregulated youth aged 13.9 (S.D. = 2.0) years, 30 female, from three clinical sites in the Longitudinal Assessment of Manic Symptoms (LAMS) study. Predictor variables included neural activity during a reward task, cortical thickness, and clinical and demographic variables. Results. Future substance use was associated with higher left middle prefrontal cortex activity, lower left ventral anterior insula activity, thicker caudal anterior cingulate cortex, higher depression and lower mania scores, not using antipsychotic medication, more parental stress, older age. This combination of variables explained 60.4% of the variance in future substance use, and accurately classified 83.6%. Conclusions. These variables explained a large proportion of the variance, were useful classifiers of future substance use, and showed the value of combining multiple domains to provide a comprehensive understanding of substance use development. This may be a step toward identifying neural measures that can identify future substance use disorder risk, and act as targets for therapeutic interventions. [ABSTRACT FROM AUTHOR]