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5. Impact of SARS-CoV-2 Omicron and Delta variants in patients requiring intensive care unit (ICU) admission for COVID-19, Northern Italy, December 2021 to January 2022

Author

Piralla, Antonio, Mojoli, Francesco, Pellegrinelli, Laura, Ceriotti, Ferruccio, Valzano, Antonia, Grasselli, Giacomo, Gismondo, Maria Rita, Micheli, Valeria, Castelli, Antonio, Farina, Claudio, Arosio, Marco, Lorini, Ferdinando Luca, Fanti, Diana, Busni, Andrea, Laratta, Matteo, Maggi, Fabrizio, Novazzi, Federica, Cabrini, Luca, Callegaro, Anna Paola, Keim, Roberto, Remuzzi, Giuseppe, Cavallero, Annalisa, Malandrin, Sergio Maria Ivano, Rona, Roberto, Giardina, Federica, Ferrari, Guglielmo, Zavaglio, Federica, D'angelo, Piera, Galli, Cristina, Bubba, Laura, Binda, Sandro, Oggioni, Massimo, Uceda Renteria, Sara Colonia, Bono, Patrizia, Baj, Andreina, Ferrante, Francesca Drago, Guarneri, Davide, Tonelli, Marco, Napolitano, Gavino, Nava, Alice, Romeo, Lorenzo, Nicolini, Elena, Valaperta, Rea, Varisano, Ludovica, Mele, Caterina, Liguori, Lucia, Raggi, Monica, Mongodi, Silvia, Pagani, Michele, Severgnini, Paolo, Gasberti, Dario, Bonanomi, Ezio, Gritti, Paolo, Marrazzo, Francesco, Giovannini, Ilaria, Sacchi, Noemi, Sagliocco, Orlando, Cereda, Danilo, Buoro, Sabrina, Baldanti, Fausto, and Pariani, Elena

Published
2023
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9. Fulminant echovirus 11 hepatitis in male non-identical twins in northern Italy, April 2023

Author

Piralla, Antonio, primary, Borghesi, Alessandro, additional, Di Comite, Amelia, additional, Giardina, Federica, additional, Ferrari, Guglielmo, additional, Zanette, Simona, additional, Figar, Tiziana Angelica, additional, Angelini, Micol, additional, Pisoni, Camilla, additional, Pitrolo, Antonino Maria Guglielmo, additional, Paolucci, Stefania, additional, Rovida, Francesca, additional, Pellicioli, Isabella, additional, Bonanomi, Ezio, additional, Baldanti, Fausto, additional, and Ghirardello, Stefano, additional

Published
2023
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11. Venous outflow obstruction in pediatric left lateral segment split liver transplantation

Author

Pinelli, D, Sansotta, N, Cavallin, F, Marra, P, Deiro, G, Camagni, S, Bonanomi, E, Sironi, S, Antiga, L, Colledan, M, Pinelli, Domenico, Sansotta, Naire, Cavallin, Francesco, Marra, Paolo, Deiro, Giacomo, Camagni, Stefania, Bonanomi, Ezio, Sironi, Sandro, Antiga, Lorenzo D', Colledan, Michele, Pinelli, D, Sansotta, N, Cavallin, F, Marra, P, Deiro, G, Camagni, S, Bonanomi, E, Sironi, S, Antiga, L, Colledan, M, Pinelli, Domenico, Sansotta, Naire, Cavallin, Francesco, Marra, Paolo, Deiro, Giacomo, Camagni, Stefania, Bonanomi, Ezio, Sironi, Sandro, Antiga, Lorenzo D', and Colledan, Michele

Abstract

Background: Venous outflow obstruction (VOO) is a known cause of graft and patient loss after pediatric liver transplantation (LT). We analyzed the incidence, risk factors, diagnosis, management, and outcome of VOO in a large, consecutive series of left lateral segment (LLS) split LT with end-to-side triangular venous anastomosis. Methods: We evaluated data collected in our prospective databases relative to all consecutive pediatric liver transplants performed from January 2006 to December 2021. We included in this study children undergoing LLS split liver transplant with end-to-side triangular anastomosis. Diagnosis of VOO was based on clinical suspicion and radiological confirmation. Results: VOO occurred in 24/279 transplants (8.6%), and it was associated with lower graft weight (p = .04), re-transplantation (p = .008), and presence of two hepatic veins (p < .0001). In presence of two segmental veins' orifices, the type of reconstruction (single anastomosis after venoplasty or double anastomosis) was not significantly related to VOO (p = .87). Multivariable analysis indicated VOO as a risk factor for graft lost (hazard ratio 3.21, 95% confidence interval 1.22-8.46; p = .01). Percutaneous Transluminal Angioplasty (PTA) was effective in 17/22 (77%) transplants. Surgical anastomosis was redone in one case. Overall six grafts (25%) were lost. Conclusion: VOO after LLS split LT with end-to-side triangular anastomosis is an unusual but critical complication leading to graft loss in a quarter of cases. The occurrence of VOO was associated with lower graft weight, re-transplantation, and presence of two hepatic veins. PTA was safe and effective to restore proper venous outflow in most cases.

Published
2023

12. Living Donor Lung Transplantation After Hematopoietic Stem Cell Transplantation From the Same Donor: A Risk Worth Taking.

Author

Camagni, Stefania, D'Antiga, Lorenzo, Di Marco, Fabiano, Grazioli, Lorenzo, Bonanomi, Ezio, Pinelli, Domenico, Beretta, Marta, Tintori, Veronica, Lucianetti, Alessandro, and Colledan, Michele

Subjects
HEMATOPOIETIC stem cell transplantation, LUNG transplantation
Abstract

Living donor (LD) lung transplantation (LT) represents an exceptional procedure in Western countries. However, in selected situations, it could be a source of unique advantages, besides addressing organ shortage. We report a successful case of father-to-child single-lobe LT, because of the complications of hematopoietic stem cell transplantation from the same donor, with initial low-dose immunosuppressive therapy and subsequent early discontinuation. Full donor chimerism was hypothesized to be a mechanism of transplant tolerance, and this postulated immunological benefit was deemed to outweigh the risks of living donation and the possible drawbacks of single compared with bilateral LT. Favorable size matching and donor's anatomy, accurate surgical planning, and specific expertise in pediatric transplantation also contributed to the optimal recipient and donor outcomes. Ten months after LD LT, the patient's steadily good lung function after withdrawal of immunosuppressive therapy seems to confirm the original hypothesis. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Italian pediatric intensive care units admitting critically ill cancer Children: results from a national survey.

Author

MARTINATO, Matteo, COMORETTO, Rosanna I., BIBAN, Paolo, ZANONATO, Elisa, SIMONINI, Alessandro, MONTAGUTI, Alessia, GITTO, Eloisa, CARAMELLI, Fabio, FERRARIO, Stefania, SAGREDINI, Raffaella, ALAIMO, Nicola, ZITO MARINOSCI, Geremia, ROSSETTI, Emanuele, CECCHETTI, Corrado, L'ERARIO, Manuela, VASILE, Beatrice, IVANI, Giorgio, BONANOMI, Ezio, ASTUTO, Marinella, and GREGORI, Dario

Published
2023
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14. Trapianto di fegato

Author

Codazzi, Daniela, Bonanomi, Ezio, Barbanti, Claudio, Lacanna, Francesco, Alberti, Daniele, Mirabile, Lorenzo, and Baroncini, Simonetta

Published
2012
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16. Positive end-expiratory pressure during Helmet ventilation in critically ill bronchiolitis: a multicenter randomized clinical trial

Author

rossetti, emanuele, primary, Ricci, Zaccaria, additional, Bonacina, Daniele, additional, Giugni, Cristina, additional, Bonanomi, Ezio, additional, Franci, Marina, additional, Atti, Marta Ciofi degli, additional, L’Erario, Manuela, additional, Perrotta, Daniela, additional, Cecchetti, Corrado, additional, appierto, linda, additional, Giudici, Luigi Dei, additional, germani, alessandro, additional, Polisca, Francesco, additional, Tortora, Francesca, additional, Farinelli, Ivano, additional, Chiusolo, Fabrizio, additional, Serio, Paolo, additional, bianchi, roberto, additional, and picardo, sergio giuseppe, additional

Published
2022
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17. Communication and visiting policies in Italian intensive care units during the first COVID-19 pandemic wave and lockdown: a nationwide survey

Author

Langer, Thomas, Depalo, Francesca Carmela, Forlini, Clarissa, Landini, Silvia, Mezzetti, Andrea, Previtali, Paola, Monti, Gianpaola, de Toma, Carolina, Biscardi, Davide, Giannini, Alberto, Fumagalli, Roberto, Mistraletti, Giovanni, Lissoni, Barbara, De Martini, Andrea, Mareto, Nadia, Rossitto, Concetta, Zummo, Ugo, Taverna, Martina, Machieraldo, Patrizia, Navarra, Mauro, Parlanti Garbero, Massimiliano, Scaletti, Chiara, Perno, Silvia, Amendolia, Luca, Montrucchio, Giuseppe, Veliaj, Deliana, Barbarello, Giuseppe, Alesci, Maria, Bolgiaghi, Luca, Vailati, Davide, Pezzi, Angelo, Boselli, Enrico, Piccoli, Francesca, Greco, Massimiliano, Gemma, Marco, Resta, Marco, Crotti, Stefania, Bottino, Nicola, Abruzzese, Chiara, Savioli, Monica, Migliorino, Giuseppina, Muttini, Stefano, Umbrello, Michele, Borghi, Beatrice, Greco, Stefano, Dizeo, Micaela, Bottiroli, Maurizio, Mondino, Michele Giovanni, Prosepri, Manlio, Casella, Giampaolo, Curto, Francesco, Zaniboni, Matteo, Giudici, Riccardo, Gentile, Carlo, Bombino, Michela, Rona, Roberto, Cortinovis, Barbara, Benini, Annalisa, Avalli, Leonello, Tavola, Mario, Ferrario, Matteo, Preda, Roberta, Primerano, Enzo, Russo, Gianluca, Porta, Virginia, Valdambrini, Federico, Fassini, Paola, Orando, Serena, Beck, Eduardo, Pedeferri, Matteo, Cogliati, Giacomina, Testini, Denise, Moroni, Benedetta, Codeluppi, Vito, Ruggeri, Patrizia, Milanesi, Elisa, Belliato, Mirko, Besozzi, Alessandra, Riccio, Mario, Zerbi, Silvia, Corbella, Davide, Ferri, Francesco, Grazioli, Lorenzo, Bonanomi, Ezio, Giacomini, Matteo, Sacchi, Noemi, Codognola, Cristian, Ambrosini, Alessandra, Guatteri, Luca, Subert, Matteo, Castelli, Gian Paolo, Borelli, Massimo, Venier, Erica, Dittura, Loredana, Buttera, Stefania, Bigai, Roberto, Magnoni, Sandra, Rauch, Simon, Colombo, Angelo, Fullin, Giorgio, Donolato, Caterina, Cattin, Silvia, State, Veronica, Redeghieri, Enrico, Russo, Alessandro, Pastorini, Simonetta, Allena, Sandra, Munari, Marina, Turchet, Federica, Peta, Mario, De Santis, Vincenzo, Scala, Cristina, Facondini, Francesca, Marangoni, Elisabetta, Tassinati, Tania, Zanzani, Chiara, Russo, Emanuele, Marchio, Annamaria, Barbagallo, Maria, Girardis, Massimo, Taffache, Paolo, Mordacci, Marco, Vincenzi, Matteo, Pennica, Michele, Bracciotti, Giovanna, Iori, Paola, Gambi, Davide, Cappellini, Iacopo, Vegnuti, Lara, De Luca, Alessandra, Romagnoli, Stefano, Mosti, Giamila, Carla, Rossella, Roticiani, Valeria, Pelagalli, Lorella, Fuselli, Ennio, D’Avino, Emilio, De Bellis, Massimo, Gianni, Giulia, Leonardis, Francesca, Rossi, Marzia, Lorusso, Rossana, Magnanimi, Eugenia, Martelli, Sabrina, Baisi, Floriana, Balsamo, Davide, Cotticelli, Virginia, Mattei, Alessia, Farinelli, Ivano, Riccini, Teresa, Cola, Luisanna, Jorio, Antonella, Iacobone, Emanuele, Domizi, Roberta, Pizzi, Simone, Nasso, Armando, Graziani, Romano, Monaco, Anna, Manno, Manuela, Ottelio, Carla Maria, Del Rio, Michela, Serra, Antonio, Enna, Barbara, Loddo, Francesco Marco, Galbiati, Rita, Mellea, Serena, Kimberly, Michelle Brozzi, Vissani, Matteo, Romito, Francesco Massimo, Baccari, Laura, Zarrillo, Nadia, Esposito, Clelia, Murino, Patrizia, Notaro, Salvatore, Ausiello, Carmine, Marra, Annachiara, Policastro, Carmela, Cafora, Chiara, De Benedectis, Giuseppe, Di Falco, Vincenzo, Sciddurlo, Maria, Negro, Giancarlo, Vetuschi, Paolo, Recchia, Andrea, Pasquariello, Rita, Squillace, Rosalba, Ciambrone, Antonio, Bencivenga, Carmela, Camiolo, Melania, Agozzino, Cristina, Oliveri, Francesco, Notarrigo, Tiziana, Castiglione, Giacomo, Mo, Antonella, Condorelli, Laura, Favarato, Martina, Langer, T, Depalo, F, Forlini, C, Landini, S, Mezzetti, A, Previtali, P, Monti, G, de Toma, C, Biscardi, D, Giannini, A, Fumagalli, R, Mistraletti, G, Lissoni, B, De Martini, A, Mareto, N, Rossitto, C, Zummo, U, Taverna, M, Machieraldo, P, Navarra, M, Parlanti Garbero, M, Scaletti, C, Perno, S, Amendolia, L, Montrucchio, G, Veliaj, D, Barbarello, G, Alesci, M, Bolgiaghi, L, Vailati, D, Pezzi, A, Boselli, E, Piccoli, F, Greco, M, Gemma, M, Resta, M, Crotti, S, Bottino, N, Abruzzese, C, Savioli, M, Migliorino, G, Muttini, S, Umbrello, M, Borghi, B, Greco, S, Dizeo, M, Bottiroli, M, Mondino, M, Prosepri, M, Casella, G, Curto, F, Zaniboni, M, Giudici, R, Gentile, C, Bombino, M, Rona, R, Cortinovis, B, Benini, A, Avalli, L, Tavola, M, Ferrario, M, Preda, R, Primerano, E, Russo, G, Porta, V, Valdambrini, F, Fassini, P, Orando, S, Beck, E, Pedeferri, M, Cogliati, G, Testini, D, Moroni, B, Codeluppi, V, Ruggeri, P, Milanesi, E, Belliato, M, Besozzi, A, Riccio, M, Zerbi, S, Corbella, D, Ferri, F, Grazioli, L, Bonanomi, E, Giacomini, M, Sacchi, N, Codognola, C, Ambrosini, A, Guatteri, L, Subert, M, Castelli, G, Borelli, M, Venier, E, Dittura, L, Buttera, S, Bigai, R, Magnoni, S, Rauch, S, Colombo, A, Fullin, G, Donolato, C, Cattin, S, State, V, Redeghieri, E, Russo, A, Pastorini, S, Allena, S, Munari, M, Turchet, F, Peta, M, De Santis, V, Scala, C, Facondini, F, Marangoni, E, Tassinati, T, Zanzani, C, Russo, E, Marchio, A, Barbagallo, M, Girardis, M, Taffache, P, Mordacci, M, Vincenzi, M, Pennica, M, Bracciotti, G, Iori, P, Gambi, D, Cappellini, I, Vegnuti, L, De Luca, A, Romagnoli, S, Mosti, G, Carla, R, Roticiani, V, Pelagalli, L, Fuselli, E, D’Avino, E, De Bellis, M, Gianni, G, Leonardis, F, Rossi, M, Lorusso, R, Magnanimi, E, Martelli, S, Baisi, F, Balsamo, D, Cotticelli, V, Mattei, A, Farinelli, I, Riccini, T, Cola, L, Jorio, A, Iacobone, E, Domizi, R, Pizzi, S, Nasso, A, Graziani, R, Monaco, A, Manno, M, Ottelio, C, Del Rio, M, Serra, A, Enna, B, Loddo, F, Galbiati, R, Mellea, S, Kimberly, M, Vissani, M, Romito, F, Baccari, L, Zarrillo, N, Esposito, C, Murino, P, Notaro, S, Ausiello, C, Marra, A, Policastro, C, Cafora, C, De Benedectis, G, Di Falco, V, Sciddurlo, M, Negro, G, Vetuschi, P, Recchia, A, Pasquariello, R, Squillace, R, Ciambrone, A, Bencivenga, C, Camiolo, M, Agozzino, C, Oliveri, F, Notarrigo, T, Castiglione, G, Mo, A, Condorelli, L, and Favarato, M

Subjects
Adult, Pandemic, Patient-centered care, Communication, COVID-19, Professional-family relations, Intensive Care Units, Policy, Anesthesiology and Pain Medicine, Health communication, Professional-family relation, Surveys and Questionnaires, Communicable Disease Control, Intensive care units, Pandemics, Humans, Intensive care unit, Child
Abstract

Background During the first coronavirus disease 2019 (COVID-19) pandemic wave, an unprecedented number of patients with respiratory failure due to a new, highly contagious virus needed hospitalization and intensive care unit (ICU) admission. The aim of the present study was to describe the communication and visiting policies of Italian intensive care units (ICUs) during the first COVID-19 pandemic wave and national lockdown and compare these data with prepandemic conditions. Methods A national web-based survey was conducted among 290 Italian hospitals. Each ICU (active between February 24 and May 31, 2020) was encouraged to complete an individual questionnaire inquiring the hospital/ICU structure/organization, communication/visiting habits and the role of clinical psychology prior to, and during the first COVID-19 pandemic wave. Results Two hundred and nine ICUs from 154 hospitals (53% of the contacted hospitals) completed the survey (202 adult and 7 pediatric ICUs). Among adult ICUs, 60% were dedicated to COVID-19 patients, 21% were dedicated to patients without COVID-19 and 19% were dedicated to both categories (Mixed). A total of 11,102 adult patients were admitted to the participating ICUs during the study period and only approximately 6% of patients received at least one visit. Communication with family members was guaranteed daily through an increased use of electronic devices and was preferentially addressed to the same family member. Compared to the prepandemic period, clinical psychologists supported physicians more often regarding communication with family members. Fewer patients received at least one visit from family members in COVID and mixed-ICUs than in non-COVID ICUs, l (0 [0–6]%, 0 [0–4]% and 11 [2–25]%, respectively, p Conclusions Visiting policies of Italian ICUs dedicated to adult patients were markedly altered during the first COVID-19 wave. Remote communication was widely adopted as a surrogate for family meetings. New strategies to favor a family-centered approach during the current and future pandemics are warranted.

Published
2022

18. 12th WINFOCUS world congress on ultrasound in emergency and critical care

Author

Acar, Yahya, Tezel, Onur, Salman, Necati, Cevik, Erdem, Algaba-Montes, Margarita, Oviedo-García, Alberto, Patricio-Bordomás, Mayra, Mahmoud, Mustafa Z., Sulieman, Abdelmoneim, Ali, Abbas, Mustafa, Alrayah, Abdelrahman, Ihab, Bahar, Mustafa, Ali, Osama, Lester Kirchner, H., Prosen, Gregor, Anzic, Ajda, Leeson, Paul, Bahreini, Maryam, Rasooli, Fatemeh, Hosseinnejad, Houman, Blecher, Gabriel, Meek, Robert, Egerton-Warburton, Diana, Ćuti, Edina Ćatić, Belina, Stanko, Vančina, Tihomir, Kovačević, Idriz, Rustemović, Nadan, Chang, Ikwan, Lee, Jin Hee, Kwak, Young Ho, Kim, Do Kyun, Cheng, Chi-Yung, Pan, Hsiu-Yung, Kung, Chia-Te, Ćurčić, Ela, Pritišanac, Ena, Planinc, Ivo, Medić, Marijana Grgić, Radonić, Radovan, Fasina, Abiola, Dean, Anthony J., Panebianco, Nova L., Henwood, Patricia S., Fochi, Oliviero, Favarato, Moreno, Bonanomi, Ezio, Tomić, Ivan, Ha, Youngrock, Toh, Hongchuen, Harmon, Elizabeth, Chan, Wilma, Baston, Cameron, Morrison, Gail, Shofer, Frances, Hua, Angela, Kim, Sharon, Tsung, James, Gunaydin, Isa, Kekec, Zeynep, Ay, Mehmet Oguzhan, Kim, Jinjoo, Kim, Jinhyun, Choi, Gyoosung, Shim, Dowon, Lee, Ji-Han, Ambrozic, Jana, Prokselj, Katja, Lucovnik, Miha, Simenc, Gabrijela Brzan, Mačiulienė, Asta, Maleckas, Almantas, Kriščiukaitis, Algimantas, Mačiulis, Vytautas, Macas, Andrius, Mohite, Sharad, Narancsik, Zoltan, Možina, Hugon, Nikolić, Sara, Hansel, Jan, Petrovčič, Rok, Mršić, Una, Orlob, Simon, Lerchbaumer, Markus, Schönegger, Niklas, Kaufmann, Reinhard, Pan, Chun-I, Wu, Chien-Hung, Pasquale, Sarah, Doniger, Stephanie J., Yellin, Sharon, Chiricolo, Gerardo, Potisek, Maja, Drnovšek, Borut, Leskovar, Boštjan, Robinson, Kristine, Kraft, Clara, Moser, Benjamin, Davis, Stephen, Layman, Shelley, Sayeed, Yusef, Minardi, Joseph, Pasic, Irmina Sefic, Dzananovic, Amra, Pasic, Anes, Zubovic, Sandra Vegar, Hauptman, Ana Godan, Brajkovic, Ana Vujaklija, Babel, Jaksa, Peklic, Marina, Radonic, Vedran, Bielen, Luka, Ming, Peh Wee, Yezid, Nur hafiza, Mohammed, Fatahul Laham, Huda, Zainal Abidin, Ismail, Wan Nasarudin Wan, Isa, W. Yus Haniff W., Fauzi, Hashairi, Seeva, Praveena, and Mazlan, Mohd Zulfakar

Published
2016
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19. Fibrinolytic Proteins and Factor XIII as Predictors of Thrombotic and Hemorrhagic Complications in Hospitalized COVID-19 Patients

Author

Marchetti, Marina, primary, Gomez-Rosas, Patricia, additional, Russo, Laura, additional, Gamba, Sara, additional, Sanga, Eleonora, additional, Verzeroli, Cristina, additional, Ambaglio, Chiara, additional, Schieppati, Francesca, additional, Restuccia, Francesco, additional, Bonanomi, Ezio, additional, Rizzi, Marco, additional, Fagiuoli, Stefano, additional, D’Alessio, Andrea, additional, Gerotziafas, Grigorios T., additional, Lorini, Luca, additional, and Falanga, Anna, additional

Published
2022
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20. Communication and visiting policies in Italian intensive care units during the first COVID-19 pandemic wave and lockdown: a nationwide survey

Author

Langer, T, Depalo, F, Forlini, C, Landini, S, Mezzetti, A, Previtali, P, Monti, G, de Toma, C, Biscardi, D, Giannini, A, Fumagalli, R, Mistraletti, G, Lissoni, B, De Martini, A, Mareto, N, Rossitto, C, Zummo, U, Taverna, M, Machieraldo, P, Navarra, M, Parlanti Garbero, M, Scaletti, C, Perno, S, Amendolia, L, Montrucchio, G, Veliaj, D, Barbarello, G, Alesci, M, Bolgiaghi, L, Vailati, D, Pezzi, A, Boselli, E, Piccoli, F, Greco, M, Gemma, M, Resta, M, Crotti, S, Bottino, N, Abruzzese, C, Savioli, M, Migliorino, G, Muttini, S, Umbrello, M, Borghi, B, Greco, S, Dizeo, M, Bottiroli, M, Mondino, M, Prosepri, M, Casella, G, Curto, F, Zaniboni, M, Giudici, R, Gentile, C, Bombino, M, Rona, R, Cortinovis, B, Benini, A, Avalli, L, Tavola, M, Ferrario, M, Preda, R, Primerano, E, Russo, G, Porta, V, Valdambrini, F, Fassini, P, Orando, S, Beck, E, Pedeferri, M, Cogliati, G, Testini, D, Moroni, B, Codeluppi, V, Ruggeri, P, Milanesi, E, Belliato, M, Besozzi, A, Riccio, M, Zerbi, S, Corbella, D, Ferri, F, Grazioli, L, Bonanomi, E, Giacomini, M, Sacchi, N, Codognola, C, Ambrosini, A, Guatteri, L, Subert, M, Castelli, G, Borelli, M, Venier, E, Dittura, L, Buttera, S, Bigai, R, Magnoni, S, Rauch, S, Colombo, A, Fullin, G, Donolato, C, Cattin, S, State, V, Redeghieri, E, Russo, A, Pastorini, S, Allena, S, Munari, M, Turchet, F, Peta, M, De Santis, V, Scala, C, Facondini, F, Marangoni, E, Tassinati, T, Zanzani, C, Russo, E, Marchio, A, Barbagallo, M, Girardis, M, Taffache, P, Mordacci, M, Vincenzi, M, Pennica, M, Bracciotti, G, Iori, P, Gambi, D, Cappellini, I, Vegnuti, L, De Luca, A, Romagnoli, S, Mosti, G, Carla, R, Roticiani, V, Pelagalli, L, Fuselli, E, D’Avino, E, De Bellis, M, Gianni, G, Leonardis, F, Rossi, M, Lorusso, R, Magnanimi, E, Martelli, S, Baisi, F, Balsamo, D, Cotticelli, V, Mattei, A, Farinelli, I, Riccini, T, Cola, L, Jorio, A, Iacobone, E, Domizi, R, Pizzi, S, Nasso, A, Graziani, R, Monaco, A, Manno, M, Ottelio, C, Del Rio, M, Serra, A, Enna, B, Loddo, F, Galbiati, R, Mellea, S, Kimberly, M, Vissani, M, Romito, F, Baccari, L, Zarrillo, N, Esposito, C, Murino, P, Notaro, S, Ausiello, C, Marra, A, Policastro, C, Cafora, C, De Benedectis, G, Di Falco, V, Sciddurlo, M, Negro, G, Vetuschi, P, Recchia, A, Pasquariello, R, Squillace, R, Ciambrone, A, Bencivenga, C, Camiolo, M, Agozzino, C, Oliveri, F, Notarrigo, T, Castiglione, G, Mo, A, Condorelli, L, Favarato, M, Langer, Thomas, Depalo, Francesca Carmela, Forlini, Clarissa, Landini, Silvia, Mezzetti, Andrea, Previtali, Paola, Monti, Gianpaola, de Toma, Carolina, Biscardi, Davide, Giannini, Alberto, Fumagalli, Roberto, Mistraletti, Giovanni, Lissoni, Barbara, De Martini, Andrea, Mareto, Nadia, Rossitto, Concetta, Zummo, Ugo, Taverna, Martina, Machieraldo, Patrizia, Navarra, Mauro, Parlanti Garbero, Massimiliano, Scaletti, Chiara, Perno, Silvia, Amendolia, Luca, Montrucchio, Giuseppe, Veliaj, Deliana, Barbarello, Giuseppe, Alesci, Maria, Bolgiaghi, Luca, Vailati, Davide, Pezzi, Angelo, Boselli, Enrico, Piccoli, Francesca, Greco, Massimiliano, Gemma, Marco, Resta, Marco, Crotti, Stefania, Bottino, Nicola, Abruzzese, Chiara, Savioli, Monica, Migliorino, Giuseppina, Muttini, Stefano, Umbrello, Michele, Borghi, Beatrice, Greco, Stefano, Dizeo, Micaela, Bottiroli, Maurizio, Mondino, Michele Giovanni, Prosepri, Manlio, Casella, Giampaolo, Curto, Francesco, Zaniboni, Matteo, Giudici, Riccardo, Gentile, Carlo, Bombino, Michela, Rona, Roberto, Cortinovis, Barbara, Benini, Annalisa, Avalli, Leonello, Tavola, Mario, Ferrario, Matteo, Preda, Roberta, Primerano, Enzo, Russo, Gianluca, Porta, Virginia, Valdambrini, Federico, Fassini, Paola, Orando, Serena, Beck, Eduardo, Pedeferri, Matteo, Cogliati, Giacomina, Testini, Denise, Moroni, Benedetta, Codeluppi, Vito, Ruggeri, Patrizia, Milanesi, Elisa, Belliato, Mirko, Besozzi, Alessandra, Riccio, Mario, Zerbi, Silvia, Corbella, Davide, Ferri, Francesco, Grazioli, Lorenzo, Bonanomi, Ezio, Giacomini, Matteo, Sacchi, Noemi, Codognola, Cristian, Ambrosini, Alessandra, Guatteri, Luca, Subert, Matteo, Castelli, Gian Paolo, Borelli, Massimo, Venier, Erica, Dittura, Loredana, Buttera, Stefania, Bigai, Roberto, Magnoni, Sandra, Rauch, Simon, Colombo, Angelo, Fullin, Giorgio, Donolato, Caterina, Cattin, Silvia, State, Veronica, Redeghieri, Enrico, Russo, Alessandro, Pastorini, Simonetta, Allena, Sandra, Munari, Marina, Turchet, Federica, Peta, Mario, De Santis, Vincenzo, Scala, Cristina, Facondini, Francesca, Marangoni, Elisabetta, Tassinati, Tania, Zanzani, Chiara, Russo, Emanuele, Marchio, Annamaria, Barbagallo, Maria, Girardis, Massimo, Taffache, Paolo, Mordacci, Marco, Vincenzi, Matteo, Pennica, Michele, Bracciotti, Giovanna, Iori, Paola, Gambi, Davide, Cappellini, Iacopo, Vegnuti, Lara, De Luca, Alessandra, Romagnoli, Stefano, Mosti, Giamila, Carla, Rossella, Roticiani, Valeria, Pelagalli, Lorella, Fuselli, Ennio, D’Avino, Emilio, De Bellis, Massimo, Gianni, Giulia, Leonardis, Francesca, Rossi, Marzia, Lorusso, Rossana, Magnanimi, Eugenia, Martelli, Sabrina, Baisi, Floriana, Balsamo, Davide, Cotticelli, Virginia, Mattei, Alessia, Farinelli, Ivano, Riccini, Teresa, Cola, Luisanna, Jorio, Antonella, Iacobone, Emanuele, Domizi, Roberta, Pizzi, Simone, Nasso, Armando, Graziani, Romano, Monaco, Anna, Manno, Manuela, Ottelio, Carla Maria, Del Rio, Michela, Serra, Antonio, Enna, Barbara, Loddo, Francesco Marco, Galbiati, Rita, Mellea, Serena, Kimberly, Michelle Brozzi, Vissani, Matteo, Romito, Francesco Massimo, Baccari, Laura, Zarrillo, Nadia, Esposito, Clelia, Murino, Patrizia, Notaro, Salvatore, Ausiello, Carmine, Marra, Annachiara, Policastro, Carmela, Cafora, Chiara, De Benedectis, Giuseppe, Di Falco, Vincenzo, Sciddurlo, Maria, Negro, Giancarlo, Vetuschi, Paolo, Recchia, Andrea, Pasquariello, Rita, Squillace, Rosalba, Ciambrone, Antonio, Bencivenga, Carmela, Camiolo, Melania, Agozzino, Cristina, Oliveri, Francesco, Notarrigo, Tiziana, Castiglione, Giacomo, Mo, Antonella, Condorelli, Laura, Favarato, Martina, Langer, T, Depalo, F, Forlini, C, Landini, S, Mezzetti, A, Previtali, P, Monti, G, de Toma, C, Biscardi, D, Giannini, A, Fumagalli, R, Mistraletti, G, Lissoni, B, De Martini, A, Mareto, N, Rossitto, C, Zummo, U, Taverna, M, Machieraldo, P, Navarra, M, Parlanti Garbero, M, Scaletti, C, Perno, S, Amendolia, L, Montrucchio, G, Veliaj, D, Barbarello, G, Alesci, M, Bolgiaghi, L, Vailati, D, Pezzi, A, Boselli, E, Piccoli, F, Greco, M, Gemma, M, Resta, M, Crotti, S, Bottino, N, Abruzzese, C, Savioli, M, Migliorino, G, Muttini, S, Umbrello, M, Borghi, B, Greco, S, Dizeo, M, Bottiroli, M, Mondino, M, Prosepri, M, Casella, G, Curto, F, Zaniboni, M, Giudici, R, Gentile, C, Bombino, M, Rona, R, Cortinovis, B, Benini, A, Avalli, L, Tavola, M, Ferrario, M, Preda, R, Primerano, E, Russo, G, Porta, V, Valdambrini, F, Fassini, P, Orando, S, Beck, E, Pedeferri, M, Cogliati, G, Testini, D, Moroni, B, Codeluppi, V, Ruggeri, P, Milanesi, E, Belliato, M, Besozzi, A, Riccio, M, Zerbi, S, Corbella, D, Ferri, F, Grazioli, L, Bonanomi, E, Giacomini, M, Sacchi, N, Codognola, C, Ambrosini, A, Guatteri, L, Subert, M, Castelli, G, Borelli, M, Venier, E, Dittura, L, Buttera, S, Bigai, R, Magnoni, S, Rauch, S, Colombo, A, Fullin, G, Donolato, C, Cattin, S, State, V, Redeghieri, E, Russo, A, Pastorini, S, Allena, S, Munari, M, Turchet, F, Peta, M, De Santis, V, Scala, C, Facondini, F, Marangoni, E, Tassinati, T, Zanzani, C, Russo, E, Marchio, A, Barbagallo, M, Girardis, M, Taffache, P, Mordacci, M, Vincenzi, M, Pennica, M, Bracciotti, G, Iori, P, Gambi, D, Cappellini, I, Vegnuti, L, De Luca, A, Romagnoli, S, Mosti, G, Carla, R, Roticiani, V, Pelagalli, L, Fuselli, E, D’Avino, E, De Bellis, M, Gianni, G, Leonardis, F, Rossi, M, Lorusso, R, Magnanimi, E, Martelli, S, Baisi, F, Balsamo, D, Cotticelli, V, Mattei, A, Farinelli, I, Riccini, T, Cola, L, Jorio, A, Iacobone, E, Domizi, R, Pizzi, S, Nasso, A, Graziani, R, Monaco, A, Manno, M, Ottelio, C, Del Rio, M, Serra, A, Enna, B, Loddo, F, Galbiati, R, Mellea, S, Kimberly, M, Vissani, M, Romito, F, Baccari, L, Zarrillo, N, Esposito, C, Murino, P, Notaro, S, Ausiello, C, Marra, A, Policastro, C, Cafora, C, De Benedectis, G, Di Falco, V, Sciddurlo, M, Negro, G, Vetuschi, P, Recchia, A, Pasquariello, R, Squillace, R, Ciambrone, A, Bencivenga, C, Camiolo, M, Agozzino, C, Oliveri, F, Notarrigo, T, Castiglione, G, Mo, A, Condorelli, L, Favarato, M, Langer, Thomas, Depalo, Francesca Carmela, Forlini, Clarissa, Landini, Silvia, Mezzetti, Andrea, Previtali, Paola, Monti, Gianpaola, de Toma, Carolina, Biscardi, Davide, Giannini, Alberto, Fumagalli, Roberto, Mistraletti, Giovanni, Lissoni, Barbara, De Martini, Andrea, Mareto, Nadia, Rossitto, Concetta, Zummo, Ugo, Taverna, Martina, Machieraldo, Patrizia, Navarra, Mauro, Parlanti Garbero, Massimiliano, Scaletti, Chiara, Perno, Silvia, Amendolia, Luca, Montrucchio, Giuseppe, Veliaj, Deliana, Barbarello, Giuseppe, Alesci, Maria, Bolgiaghi, Luca, Vailati, Davide, Pezzi, Angelo, Boselli, Enrico, Piccoli, Francesca, Greco, Massimiliano, Gemma, Marco, Resta, Marco, Crotti, Stefania, Bottino, Nicola, Abruzzese, Chiara, Savioli, Monica, Migliorino, Giuseppina, Muttini, Stefano, Umbrello, Michele, Borghi, Beatrice, Greco, Stefano, Dizeo, Micaela, Bottiroli, Maurizio, Mondino, Michele Giovanni, Prosepri, Manlio, Casella, Giampaolo, Curto, Francesco, Zaniboni, Matteo, Giudici, Riccardo, Gentile, Carlo, Bombino, Michela, Rona, Roberto, Cortinovis, Barbara, Benini, Annalisa, Avalli, Leonello, Tavola, Mario, Ferrario, Matteo, Preda, Roberta, Primerano, Enzo, Russo, Gianluca, Porta, Virginia, Valdambrini, Federico, Fassini, Paola, Orando, Serena, Beck, Eduardo, Pedeferri, Matteo, Cogliati, Giacomina, Testini, Denise, Moroni, Benedetta, Codeluppi, Vito, Ruggeri, Patrizia, Milanesi, Elisa, Belliato, Mirko, Besozzi, Alessandra, Riccio, Mario, Zerbi, Silvia, Corbella, Davide, Ferri, Francesco, Grazioli, Lorenzo, Bonanomi, Ezio, Giacomini, Matteo, Sacchi, Noemi, Codognola, Cristian, Ambrosini, Alessandra, Guatteri, Luca, Subert, Matteo, Castelli, Gian Paolo, Borelli, Massimo, Venier, Erica, Dittura, Loredana, Buttera, Stefania, Bigai, Roberto, Magnoni, Sandra, Rauch, Simon, Colombo, Angelo, Fullin, Giorgio, Donolato, Caterina, Cattin, Silvia, State, Veronica, Redeghieri, Enrico, Russo, Alessandro, Pastorini, Simonetta, Allena, Sandra, Munari, Marina, Turchet, Federica, Peta, Mario, De Santis, Vincenzo, Scala, Cristina, Facondini, Francesca, Marangoni, Elisabetta, Tassinati, Tania, Zanzani, Chiara, Russo, Emanuele, Marchio, Annamaria, Barbagallo, Maria, Girardis, Massimo, Taffache, Paolo, Mordacci, Marco, Vincenzi, Matteo, Pennica, Michele, Bracciotti, Giovanna, Iori, Paola, Gambi, Davide, Cappellini, Iacopo, Vegnuti, Lara, De Luca, Alessandra, Romagnoli, Stefano, Mosti, Giamila, Carla, Rossella, Roticiani, Valeria, Pelagalli, Lorella, Fuselli, Ennio, D’Avino, Emilio, De Bellis, Massimo, Gianni, Giulia, Leonardis, Francesca, Rossi, Marzia, Lorusso, Rossana, Magnanimi, Eugenia, Martelli, Sabrina, Baisi, Floriana, Balsamo, Davide, Cotticelli, Virginia, Mattei, Alessia, Farinelli, Ivano, Riccini, Teresa, Cola, Luisanna, Jorio, Antonella, Iacobone, Emanuele, Domizi, Roberta, Pizzi, Simone, Nasso, Armando, Graziani, Romano, Monaco, Anna, Manno, Manuela, Ottelio, Carla Maria, Del Rio, Michela, Serra, Antonio, Enna, Barbara, Loddo, Francesco Marco, Galbiati, Rita, Mellea, Serena, Kimberly, Michelle Brozzi, Vissani, Matteo, Romito, Francesco Massimo, Baccari, Laura, Zarrillo, Nadia, Esposito, Clelia, Murino, Patrizia, Notaro, Salvatore, Ausiello, Carmine, Marra, Annachiara, Policastro, Carmela, Cafora, Chiara, De Benedectis, Giuseppe, Di Falco, Vincenzo, Sciddurlo, Maria, Negro, Giancarlo, Vetuschi, Paolo, Recchia, Andrea, Pasquariello, Rita, Squillace, Rosalba, Ciambrone, Antonio, Bencivenga, Carmela, Camiolo, Melania, Agozzino, Cristina, Oliveri, Francesco, Notarrigo, Tiziana, Castiglione, Giacomo, Mo, Antonella, Condorelli, Laura, and Favarato, Martina

Abstract

Background: During the first coronavirus disease 2019 (COVID-19) pandemic wave, an unprecedented number of patients with respiratory failure due to a new, highly contagious virus needed hospitalization and intensive care unit (ICU) admission. The aim of the present study was to describe the communication and visiting policies of Italian intensive care units (ICUs) during the first COVID-19 pandemic wave and national lockdown and compare these data with prepandemic conditions. Methods: A national web-based survey was conducted among 290 Italian hospitals. Each ICU (active between February 24 and May 31, 2020) was encouraged to complete an individual questionnaire inquiring the hospital/ICU structure/organization, communication/visiting habits and the role of clinical psychology prior to, and during the first COVID-19 pandemic wave. Results: Two hundred and nine ICUs from 154 hospitals (53% of the contacted hospitals) completed the survey (202 adult and 7 pediatric ICUs). Among adult ICUs, 60% were dedicated to COVID-19 patients, 21% were dedicated to patients without COVID-19 and 19% were dedicated to both categories (Mixed). A total of 11,102 adult patients were admitted to the participating ICUs during the study period and only approximately 6% of patients received at least one visit. Communication with family members was guaranteed daily through an increased use of electronic devices and was preferentially addressed to the same family member. Compared to the prepandemic period, clinical psychologists supported physicians more often regarding communication with family members. Fewer patients received at least one visit from family members in COVID and mixed-ICUs than in non-COVID ICUs, l (0 [0-6]%, 0 [0-4]% and 11 [2-25]%, respectively, p < 0.001). Habits of pediatric ICUs were less affected by the pandemic. Conclusions: Visiting policies of Italian ICUs dedicated to adult patients were markedly altered during the first COVID-19 wave. Remote communication was wi

Published
2022

21. Fibrinolytic Proteins and Factor XIII as Predictors of Thrombotic and Hemorrhagic Complications in Hospitalized COVID-19 Patients

Author

Marchetti, M, Gomez-Rosas, P, Russo, L, Gamba, S, Sanga, E, Verzeroli, C, Ambaglio, C, Schieppati, F, Restuccia, F, Bonanomi, E, Rizzi, M, Fagiuoli, S, D'Alessio, A, Gerotziafas, G, Lorini, L, Falanga, A, Marchetti, Marina, Gomez-Rosas, Patricia, Russo, Laura, Gamba, Sara, Sanga, Eleonora, Verzeroli, Cristina, Ambaglio, Chiara, Schieppati, Francesca, Restuccia, Francesco, Bonanomi, Ezio, Rizzi, Marco, Fagiuoli, Stefano, D'Alessio, Andrea, Gerotziafas, Grigorios T, Lorini, Luca, Falanga, Anna, Marchetti, M, Gomez-Rosas, P, Russo, L, Gamba, S, Sanga, E, Verzeroli, C, Ambaglio, C, Schieppati, F, Restuccia, F, Bonanomi, E, Rizzi, M, Fagiuoli, S, D'Alessio, A, Gerotziafas, G, Lorini, L, Falanga, A, Marchetti, Marina, Gomez-Rosas, Patricia, Russo, Laura, Gamba, Sara, Sanga, Eleonora, Verzeroli, Cristina, Ambaglio, Chiara, Schieppati, Francesca, Restuccia, Francesco, Bonanomi, Ezio, Rizzi, Marco, Fagiuoli, Stefano, D'Alessio, Andrea, Gerotziafas, Grigorios T, Lorini, Luca, and Falanga, Anna

Abstract

IntroductionIn a prospective cohort of hospitalized COVID-19 patients, an extensive characterization of hemostatic alterations by both global and specific assays was performed to clarify mechanisms underlying the coagulopathy and identify predictive factors for thrombotic and hemorrhagic events during hospitalization. Materials and MethodsIntensive care unit (ICU; n = 46) and non-ICU (n = 55) patients were enrolled, and the occurrence of thrombotic and hemorrhagic events was prospectively monitored. At study inclusion, thromboelastometry together with the measurement of specific coagulation proteins and hypercoagulation markers was performed. ResultsPatients (median age 67 years) showed significantly shorter clot formation time together with greater maximum clot firmness by thromboelastometry, increased levels of F1 + 2 and D-dimer, as biomarkers of hypercoagulability, and of procoagulant factors V, VIII, IX, XI, and fibrinogen, while FXIII was significantly reduced. The concentration of fibrinolytic proteins, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) were elevated in the overall cohort of patients. Many of these hemostatic alterations were significantly greater in ICU compared to non-ICU subjects and, furthermore, they were associated with inflammatory biomarker elevation [i.e., interleukin 6 (IL-6), C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), and procalcitonin]. After enrollment, 7 thrombosis and 14 major bleedings occurred. Analysis of clinical and biological data identified increased t-PA, PAI-1, and NLR values as independent predictive factors for thrombosis, while lower FXIII levels were associated with bleeding. ConclusionThis study demonstrates alterations in all different hemostatic compartments analyzed, particularly in severe COVID-19 conditions, that strongly correlated with the inflammatory status. A potential role of fibrinolytic proteins together with NLR and of FXIII as predictors of th

Published
2022

22. Not Only Diagnostic Yield: Whole-Exome Sequencing in Infantile Cardiomyopathies Impacts on Clinical and Family Management

Author

Pezzoli, Laura, primary, Pezzani, Lidia, additional, Bonanomi, Ezio, additional, Marrone, Chiara, additional, Scatigno, Agnese, additional, Cereda, Anna, additional, Bedeschi, Maria Francesca, additional, Selicorni, Angelo, additional, Gasperini, Serena, additional, Bini, Paolo, additional, Maitz, Silvia, additional, Maccioni, Carla, additional, Pedron, Cristina, additional, Colombo, Lorenzo, additional, Marchetti, Daniela, additional, Bellini, Matteo, additional, Lincesso, Anna Rita, additional, Perego, Loredana, additional, Pingue, Monica, additional, Della Malva, Nunzia, additional, Mangili, Giovanna, additional, Ferrazzi, Paolo, additional, and Iascone, Maria, additional

Published
2021
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23. Parental presence in Italian pediatric intensive care units: a reappraisal of current visiting policies

Author

Giannini, Alberto, Miccinesi, Guido, Prandi, Edi, Dusio, Maria Pia, Greggio, Marta, Laganà, Ignazia, Falcioni, Ilenia, Grieco, Luana, Gentile, Fabio, Bonanomi, Ezio, Vitali, Giuliana, Mondardini, Maria Cristina, Lazzarini, Rossella, Fucà, Antonietta, Gulino, Geltrude, Barzini, Patrizia, Scalfi, Mariarosa, Altadonna, Fiammetta, Vitali, Silvana, Pennica, Michele, Albina, Chiara, Franceschi, Alessia, Giorgini Pasinato, Valentina, Barberi, Elisa, Nardini, Francesca, Zoia, Elena, Deodato, Roberta, Marchesi, Tiziana, Madeo, Mario, Gagliardone, Maria Pia, Ghezzi, Elisa, Isgrò, Giuseppe, Mangiatordi, Stefania, Storti, Maria, Sorrentino, Marianna, Palladino, Maria Teresa, Longobardo, Flavia, Pettenazzo, Andrea, Zaggia, Cristina, Coffaro, Giancarlo, Contino, Antonella, Pulitanò, Silvia, Piazza, Stefania, Bianchi, Roberto, Franci, Marina, Cecchetti, Corrado, Cancani, Federica, Schloderer, Ulrike Inge Elisabeth, Timpani, Sabrina, Corbari, Maurizio, Di Furia, Michela, Ruggeri, Anna, Papoff, Paola, Grasso, Nadia, Trischitta, Giuseppe, Conio, Alessandra, Spiccia, Massimiliano, Iannandrea, Stefania, Bruna, Paola, Furlan, Stefano, Micali, Adriana, Buchini, Sara, Biban, Paolo, Tosin, Chiara, and ODIN Study Group 2

Published
2017
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25. Infantile ATP7B-Related End-Stage Liver Disease: An Exceptional Wilson Disease Phenotype From Consecutive Generations

Author

Nicastro, Emanuele, primary, Iascone, Maria, additional, Di Giorgio, Angelo, additional, Brecelj, Jernej, additional, Petruzzelli, Raffaella, additional, Polishchuk, Roman S., additional, Deheragoda, Maesha, additional, Wagner, Bart E., additional, Sonzogni, Aurelio, additional, Bonanomi, Ezio, additional, and D’Antiga, Lorenzo, additional

Published
2021
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26. Endothelium Activation Markers in Severe Hospitalized COVID-19 Patients: Role in Mortality Risk Prediction

Author

Marchetti, Marina, additional, Gomez-Rosas, Patricia, additional, Sanga, Eleonora, additional, Gamba, Sara, additional, Verzeroli, Cristina, additional, Russo, Laura, additional, Restuccia, Francesco, additional, Schieppati, Francesca, additional, Bonanomi, Ezio, additional, Rizzi, Marco, additional, Fagiuoli, Stefano, additional, D'Alessio, Andrea, additional, Lorini, Luca, additional, and Falanga, Anna, additional

Published
2021
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27. Arterioportal Fistulas (APFs) in Pediatric Patients: Single Center Experience with Interventional Radiological versus Conservative Management and Clinical Outcomes

Author

Marra, Paolo, primary, Dulcetta, Ludovico, additional, Carbone, Francesco Saverio, additional, Agazzi, Roberto, additional, Muglia, Riccardo, additional, Bonaffini, Pietro Andrea, additional, Bonanomi, Ezio, additional, Colledan, Michele, additional, D’Antiga, Lorenzo, additional, Venturini, Massimo, additional, and Sironi, Sandro, additional

Published
2021
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30. Post-operative heparin reduces early venous thrombotic complications after orthotopic paediatric liver transplantation

Author

Colombo, Giovanna, Giaccherini, Cinzia, Benzi, Alberto, Ferrari, Floriana, Bonacina, Daniele, Corno, Manuela, Colledan, Michele, Alessio, Maria Grazia, Bonanomi, Ezio, Nacoti, Mirco, Falanga, Anna, Colombo, G, Giaccherini, C, Benzi, A, Ferrari, F, Bonacina, D, Corno, M, Colledan, M, Alessio, M, Bonanomi, E, Nacoti, M, and Falanga, A

Subjects
Postoperative Complications, liver transplantation, children, Heparin, Anticoagulants, Humans, thrombosi, Thrombosis, Child, Haemostasis and Thrombosis, Retrospective Studies
Abstract

BACKGROUND: Despite significant improvements in surgical techniques and medical care, thrombotic complications still represent the primary cause of early graft failure and re-transplantation following paediatric liver transplantation. There is still no standardized approach for thrombosis prevention. MATERIALS AND METHODS: The study aimed to evaluate the effectiveness of early intravenous unfractionated heparin started 12 hours postoperatively at 10 UI/kg per hour and used a retrospective "before and after" design to compare the incidence of early thrombotic complications prior to (2002-2010) and after (2011-2016) the introduction of heparin in our institute. RESULTS: From 2002 to 2016, 479 paediatric patients received liver transplantation in our institution with an overall survival rate over one year of 0.91 (95% CI: 0.87-0.94). Of 365 eligible patients, 244 did not receive heparin while 121 did receive heparin. We reported a lower incidence of venous thrombosis (VT) in the group treated with heparin: 2.5% (3/121) vs 7.9% (19/244) (p=0.038). All clinical and laboratory variables considered potential risk factors for VT were studied. By multivariate stepwise Cox proportional hazards models, heparin prophylaxis resulted significantly associated to a reduction in VT (HR=0.29 [95% CI: 0.08-0.97], p=0.045), while age

Published
2021

31. Modified pediatric Lung Ultrasound Score compared with computed tomography for assessment of lung aeration in children

Author

Fochi, O, Bronco, A, Nacoti, M, Signori, D, Gatti, S, Sala, F, Rozen, T, Bonanomi, E, Bellani, G, Fochi, Oliviero, Bronco, Alfio, Nacoti, Mirco, Signori, Davide, Gatti, Stefano, Sala, Francesco, Rozen, Thomas, Bonanomi, Ezio, Bellani, Giacomo, Fochi, O, Bronco, A, Nacoti, M, Signori, D, Gatti, S, Sala, F, Rozen, T, Bonanomi, E, Bellani, G, Fochi, Oliviero, Bronco, Alfio, Nacoti, Mirco, Signori, Davide, Gatti, Stefano, Sala, Francesco, Rozen, Thomas, Bonanomi, Ezio, and Bellani, Giacomo

Abstract

BACKGROUND: Lung ultrasound can be used to assess lung density and aeration at the bedside. A few authors have investigated scores based on the ultrasonographic interstitial syndrome for this purpose, but none have compared them with the gold standard computed tomography in children.METHODS: Children < 10 kilograms undergoing a chest computed tomography for clinical purposes at a tertiary hospital Pediatric Intensive Care Unit were enrolled in the study. An ultrasound scan was performed shortly after computed tomography. Each hemithorax was divided in 6 zones, and each zone was scored: 1 = no B lines; 2 = < 3 B lines; 3 > 3 well separated B lines; 4 = crowded, coalescent B lines; 5 = white lung; 6 = consolidation. The pediatric Lung Ultrasound Score was obtained by adding all zones. Interobserver variation for two separate operators was calculated.RESULTS: Ten children, median age 95 days (range 23 - 721), were enrolled. Mean pediatric Lung Ultrasound Score had a significant correlation with lung density (rho = 0.68) and percentage of hypoaerated lung (rho = 0.51). Median density and percentage of hypoaerated lung increased along the ultrasound patterns values (p < 0.05) although not all patterns were significantly different from adjacent ones in the pairwise comparison. Interobserver variability in scoring of ultrasonographic patterns was moderate.CONCLUSIONS: The pediatric Lung Ultrasound Score correlates with lung density and percentage of hypoaerated lung measured with computed tomography.

Published
2021

32. Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy

Author

Grasselli, G, Greco, M, Zanella, A, Albano, G, Antonelli, M, Bellani, G, Bonanomi, E, Cabrini, L, Carlesso, E, Castelli, G, Cattaneo, S, Cereda, D, Colombo, S, Coluccello, A, Crescini, G, Forastieri Molinari, A, Foti, G, Fumagalli, R, Iotti, G, Langer, T, Latronico, N, Lorini, F, Mojoli, F, Natalini, G, Pessina, C, Ranieri, V, Rech, R, Scudeller, L, Rosano, A, Storti, E, Thompson, B, Tirani, M, Villani, P, Pesenti, A, Cecconi, M, Grasselli, Giacomo, Greco, Massimiliano, Zanella, Alberto, Albano, Giovanni, Antonelli, Massimo, Bellani, Giacomo, Bonanomi, Ezio, Cabrini, Luca, Carlesso, Eleonora, Castelli, Gianpaolo, Cattaneo, Sergio, Cereda, Danilo, Colombo, Sergio, Coluccello, Antonio, Crescini, Giuseppe, Forastieri Molinari, Andrea, Foti, Giuseppe, Fumagalli, Roberto, Iotti, Giorgio Antonio, Langer, Thomas, Latronico, Nicola, Lorini, Ferdinando Luca, Mojoli, Francesco, Natalini, Giuseppe, Pessina, Carla Maria, Ranieri, Vito Marco, Rech, Roberto, Scudeller, Luigia, Rosano, Antonio, Storti, Enrico, Thompson, B Taylor, Tirani, Marcello, Villani, Pier Giorgio, Pesenti, Antonio, Cecconi, Maurizio, Grasselli, G, Greco, M, Zanella, A, Albano, G, Antonelli, M, Bellani, G, Bonanomi, E, Cabrini, L, Carlesso, E, Castelli, G, Cattaneo, S, Cereda, D, Colombo, S, Coluccello, A, Crescini, G, Forastieri Molinari, A, Foti, G, Fumagalli, R, Iotti, G, Langer, T, Latronico, N, Lorini, F, Mojoli, F, Natalini, G, Pessina, C, Ranieri, V, Rech, R, Scudeller, L, Rosano, A, Storti, E, Thompson, B, Tirani, M, Villani, P, Pesenti, A, Cecconi, M, Grasselli, Giacomo, Greco, Massimiliano, Zanella, Alberto, Albano, Giovanni, Antonelli, Massimo, Bellani, Giacomo, Bonanomi, Ezio, Cabrini, Luca, Carlesso, Eleonora, Castelli, Gianpaolo, Cattaneo, Sergio, Cereda, Danilo, Colombo, Sergio, Coluccello, Antonio, Crescini, Giuseppe, Forastieri Molinari, Andrea, Foti, Giuseppe, Fumagalli, Roberto, Iotti, Giorgio Antonio, Langer, Thomas, Latronico, Nicola, Lorini, Ferdinando Luca, Mojoli, Francesco, Natalini, Giuseppe, Pessina, Carla Maria, Ranieri, Vito Marco, Rech, Roberto, Scudeller, Luigia, Rosano, Antonio, Storti, Enrico, Thompson, B Taylor, Tirani, Marcello, Villani, Pier Giorgio, Pesenti, Antonio, and Cecconi, Maurizio

Abstract

Importance: Many patients with coronavirus disease 2019 (COVID-19) are critically ill and require care in the intensive care unit (ICU). Objective: To evaluate the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in ICUs in the Lombardy region of Italy. Design, setting, and participants: This retrospective, observational cohort study included 3988 consecutive critically ill patients with laboratory-confirmed COVID-19 referred for ICU admission to the coordinating center (Fondazione IRCCS [Istituto di Ricovero e Cura a Carattere Scientifico] Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy) of the COVID-19 Lombardy ICU Network from February 20 to April 22, 2020. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by real-time reverse transcriptase-polymerase chain reaction assay of nasopharyngeal swabs. Follow-up was completed on May 30, 2020. Exposures: Baseline characteristics, comorbidities, long-term medications, and ventilatory support at ICU admission. Main outcomes and measures: Time to death in days from ICU admission to hospital discharge. The independent risk factors associated with mortality were evaluated with a multivariable Cox proportional hazards regression. Results: Of the 3988 patients included in this cohort study, the median age was 63 (interquartile range [IQR] 56-69) years; 3188 (79.9%; 95% CI, 78.7%-81.1%) were men, and 1998 of 3300 (60.5%; 95% CI, 58.9%-62.2%) had at least 1 comorbidity. At ICU admission, 2929 patients (87.3%; 95% CI, 86.1%-88.4%) required invasive mechanical ventilation (IMV). The median follow-up was 44 (95% CI, 40-47; IQR, 11-69; range, 0-100) days; median time from symptoms onset to ICU admission was 10 (95% CI, 9-10; IQR, 6-14) days; median length of ICU stay was 12 (95% CI, 12-13; IQR, 6-21) days; and median length of IMV was 10 (95% CI, 10-11; IQR, 6-17) days. Cumulative observation time was 164 305 patient-days. Hospital and ICU mortality ra

Published
2020

34. Extensive Characterization of the Hemostatic Derangement Occurring in COVID-19 Patients Admitted to the Bergamo Hospital

Author

Gomez-Rosas, Patricia, primary, Marchetti, Marina, additional, Sanga, Eleonora, additional, Gamba, Sara, additional, Verzeroli, Cristina, additional, Russo, Laura, additional, Restuccia, Francesco, additional, D'Alessio, Andrea, additional, Bonanomi, Ezio, additional, Rizzi, Marco, additional, Fagiuoli, Stefano, additional, Lorini, Luca, additional, and Falanga, Anna, additional

Published
2020
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35. Efficacy and safety of exogenous surfactant therapy in patients under 12 months of age invasively ventilated for severe bronchiolitis (SURFABRON): protocol for a multicentre, randomised, double-blind, controlled, non-profit trial

Author

Biban, Paolo, primary, Conti, Giorgio, additional, Wolfler, Andrea Michele, additional, Carlassara, Silvia, additional, Gitto, Eloisa, additional, Rulli, Immacolata, additional, Moscatelli, Andrea, additional, Micalizzi, Camilla, additional, Savron, Fabio, additional, Sagredini, Raffaella, additional, Genoni, Giulia, additional, Binotti, Marco, additional, Caramelli, Fabio, additional, Fae, Monica, additional, Pettenazzo, Andrea, additional, Stritoni, Valentina, additional, D’Amato, Luigia, additional, Zito Marinosci, Geremia, additional, Calderini, Edoardo, additional, Scalia Catenacci, Stefano, additional, Berardi, Alberto, additional, Torcetta, Francesco, additional, Bonanomi, Ezio, additional, Bonacina, Daniele, additional, Ivani, Giorgio, additional, and Santuz, Pierantonio, additional

Published
2020
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40. Double homozygosity in CEP57 and DYNC2H1 genes detected by WES: Composite or expanded phenotype?

Author

Pezzani, Lidia, primary, Pezzoli, Laura, additional, Pansa, Alessandra, additional, Facchinetti, Barbara, additional, Marchetti, Daniela, additional, Scatigno, Agnese, additional, Lincesso, Anna R., additional, Perego, Loredana, additional, Pingue, Monica, additional, Pellicioli, Isabella, additional, Migliazza, Lucia, additional, Mangili, Giovanna, additional, Galletti, Lorenzo, additional, Giussani, Ursula, additional, Bonanomi, Ezio, additional, Cereda, Anna, additional, and Iascone, Maria, additional

Published
2020
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43. Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy

Author

Grasselli, Giacomo, Greco, Massimiliano, Zanella, Alberto, Albano, Giovanni, Antonelli, Massimo, Bellani, Giacomo, Bonanomi, Ezio, Cabrini, Luca, Carlesso, Eleonora, Castelli, Gianpaolo, Cattaneo, Sergio, Cereda, Danilo, Colombo, Sergio, Coluccello, Antonio, Crescini, Giuseppe, Forastieri Molinari, Andrea, Foti, Giuseppe, Fumagalli, Roberto, Iotti, Giorgio Antonio, Langer, Thomas, Latronico, Nicola, Lorini, Ferdinando Luca, Mojoli, Francesco, Natalini, Giuseppe, Pessina, Carla Maria, Ranieri, Vito Marco, Rech, Roberto, Scudeller, Luigia, Rosano, Antonio, Storti, Enrico, Thompson, B. Taylor, Tirani, Marcello, Villani, Pier Giorgio, Pesenti, Antonio, Cecconi, Maurizio, Agosteo, Emiliano, Albertin, Andrea, Alborghetti, Armando, Aldegheri, Giorgio, Antonini, Benvenuto, Barbara, Enrico, Bardelloni, Giulia, Basilico, Sabrina, Belgiorno, Nicolangela, Beretta, Enrico, Berselli, Angela, Bianciardi, Leonardo, Bonazzi, Stefano, Borelli, Massimo, Bottino, Nicola, Bronzini, Nicola, Brusatori, Serena, Capra, Carlo, Carnevale, Livio, Catena, Emanuele, Celotti, Simona, Cerutti, Stefania, Chiumello, Davide, Cirri, Silvia, Citerio, Giuseppe, Coppini, Davide, Corona, Alberto, Cortellazzi, Paolo, Costantini, Elena, Covello, Remo Daniel, De Filippi, Gianluca, Dei Poli, Marco, Dughi, Paolo, Fieni, Fulvia, Florio, Gaetano, Galletti, Marco, Gallioli, Giorgio Antonio, Gay, Hedwige, Gemma, Marco, Gnesin, Paolo, Greco, Stefano, Grosso, Paolo, Guatteri, Luca, Guzzon, Davide, Keim, Roberto, Lombardo, Andrea, Mamprin, Filippo, Marino, Giovanni, Marino, Francesco, Merli, Guido, Micucci, Antonio, Militano, Carmine Rocco, Monti, Giacomo, Muttini, Stefano, Nadalin, Samantha, Perazzo, Paolo, Perego, Giovanni Battista, Perotti, Luciano, Petrucci, Nicola, Pezzi, Angelo, Piva, Simone, Portella, Gina, Protti, Alessandro, Racagni, Milena, Radrizzani, Danilo, Raimondi, Maurizio, Ranucci, Marco, Riccio, Mario, Ruggeri, Patrizia, Sala, Giuseppe, Salvi, Luca, Sebastiano, Pietro, Severgnini, Paolo, Sigurtà, Donato, Stocchetti, Nino, Subert, Matteo, Tavola, Mario, Todaro, Serena, Torriglia, Francesca, Tubiolo, Daniela, Valsecchi, Roberto, Viola, Uberto, Vitale, Giovanni, Zambon, Massimo, Zoia, Elena, Grasselli, G, Greco, M, Zanella, A, Albano, G, Antonelli, M, Bellani, G, Bonanomi, E, Cabrini, L, Carlesso, E, Castelli, G, Cattaneo, S, Cereda, D, Colombo, S, Coluccello, A, Crescini, G, Forastieri Molinari, A, Foti, G, Fumagalli, R, Iotti, G, Langer, T, Latronico, N, Lorini, F, Mojoli, F, Natalini, G, Pessina, C, Ranieri, V, Rech, R, Scudeller, L, Rosano, A, Storti, E, Thompson, B, Tirani, M, Villani, P, Pesenti, A, Cecconi, M, Grasselli G., Greco M., Zanella A., Albano G., Antonelli M., Bellani G., Bonanomi E., Cabrini L., Carlesso E., Castelli G., Cattaneo S., Cereda D., Colombo S., Coluccello A., Crescini G., Forastieri Molinari A., Foti G., Fumagalli R., Iotti G.A., Langer T., Latronico N., Lorini F.L., Mojoli F., Natalini G., Pessina C.M., Ranieri V.M., Rech R., Scudeller L., Rosano A., Storti E., Thompson B.T., Tirani M., Villani P.G., Pesenti A., and Cecconi M.

Subjects
medicine.medical_specialty, COVID19, mechanical ventilation, 01 natural sciences, law.invention, 03 medical and health sciences, 0302 clinical medicine, COVID-19, ICU, critical illness, mechanical ventilation, mortality, Interquartile range, law, Intensive care, Internal medicine, Internal Medicine, critical illness, Medicine, 030212 general & internal medicine, 0101 mathematics, Risk factor, business.industry, Mortality rate, 010102 general mathematics, Hazard ratio, COVID-19, Retrospective cohort study, mortality, Intensive care unit, ICU, na, business, Cohort study
Abstract

Importance Many patients with coronavirus disease 2019 (COVID-19) are critically ill and require care in the intensive care unit (ICU). Objective To evaluate the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in ICUs in the Lombardy region of Italy. Design, Setting, and Participants This retrospective, observational cohort study included 3988 consecutive critically ill patients with laboratory-confirmed COVID-19 referred for ICU admission to the coordinating center (Fondazione IRCCS [Istituto di Ricovero e Cura a Carattere Scientifico] Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy) of the COVID-19 Lombardy ICU Network from February 20 to April 22, 2020. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by real-time reverse transcriptase–polymerase chain reaction assay of nasopharyngeal swabs. Follow-up was completed on May 30, 2020. Exposures Baseline characteristics, comorbidities, long-term medications, and ventilatory support at ICU admission. Main Outcomes and Measures Time to death in days from ICU admission to hospital discharge. The independent risk factors associated with mortality were evaluated with a multivariable Cox proportional hazards regression. Results Of the 3988 patients included in this cohort study, the median age was 63 (interquartile range [IQR] 56-69) years; 3188 (79.9%; 95% CI, 78.7%-81.1%) were men, and 1998 of 3300 (60.5%; 95% CI, 58.9%-62.2%) had at least 1 comorbidity. At ICU admission, 2929 patients (87.3%; 95% CI, 86.1%-88.4%) required invasive mechanical ventilation (IMV). The median follow-up was 44 (95% CI, 40-47; IQR, 11-69; range, 0-100) days; median time from symptoms onset to ICU admission was 10 (95% CI, 9-10; IQR, 6-14) days; median length of ICU stay was 12 (95% CI, 12-13; IQR, 6-21) days; and median length of IMV was 10 (95% CI, 10-11; IQR, 6-17) days. Cumulative observation time was 164 305 patient-days. Hospital and ICU mortality rates were 12 (95% CI, 11-12) and 27 (95% CI, 26-29) per 1000 patients-days, respectively. In the subgroup of the first 1715 patients, as of May 30, 2020, 865 (50.4%) had been discharged from the ICU, 836 (48.7%) had died in the ICU, and 14 (0.8%) were still in the ICU; overall, 915 patients (53.4%) died in the hospital. Independent risk factors associated with mortality included older age (hazard ratio [HR], 1.75; 95% CI, 1.60-1.92), male sex (HR, 1.57; 95% CI, 1.31-1.88), high fraction of inspired oxygen (Fio2) (HR, 1.14; 95% CI, 1.10-1.19), high positive end-expiratory pressure (HR, 1.04; 95% CI, 1.01-1.06) or low Pao2:Fio2ratio (HR, 0.80; 95% CI, 0.74-0.87) on ICU admission, and history of chronic obstructive pulmonary disease (HR, 1.68; 95% CI, 1.28-2.19), hypercholesterolemia (HR, 1.25; 95% CI, 1.02-1.52), and type 2 diabetes (HR, 1.18; 95% CI, 1.01-1.39). No medication was independently associated with mortality (angiotensin-converting enzyme inhibitors HR, 1.17; 95% CI, 0.97-1.42; angiotensin receptor blockers HR, 1.05; 95% CI, 0.85-1.29). Conclusions and Relevance In this retrospective cohort study of critically ill patients admitted to ICUs in Lombardy, Italy, with laboratory-confirmed COVID-19, most patients required IMV. The mortality rate and absolute mortality were high.

Published
2020

44. Heparin-like effect resistant to protamine in a child with haemorrhagic shock. Do we need heparinase?

Author

Nacoti, Mirco, Cantù, Diego, Bonacina, Daniele, Lussana, Federico, Bonanomi, Ezio, Marchetti, Marina, Falanga, Anna, Nacoti, M, Cantù, D, Bonacina, D, Lussana, F, Bonanomi, E, Marchetti, M, and Falanga, A

Subjects
Male, Heparin, bleeding, children, liver failure, thromboelastography, Bleeding, Drug Resistance, Liver failure, Infant, Case Report, Blood Component Transfusion, Shock, Hemorrhagic, Thrombelastography, Fatal Outcome, Heparin Lyase, Thromboelastography, Humans, Protamines, Children
Published
2018

46. Sevoflurane improves respiratory mechanics and gas exchange in a case series of infants with severe bronchiolitis-induced acute respiratory distress syndrome

Author

Nacoti, M, Colombo, J, Fochi, O, Bonacina, D, Fazzi, F, Bellani, G, Bonanomi, E, Nacoti, Mirco, Colombo, Jacopo, Fochi, Oliviero, Bonacina, Daniele, Fazzi, Francesco, Bellani, Giacomo, Bonanomi, Ezio, Nacoti, M, Colombo, J, Fochi, O, Bonacina, D, Fazzi, F, Bellani, G, Bonanomi, E, Nacoti, Mirco, Colombo, Jacopo, Fochi, Oliviero, Bonacina, Daniele, Fazzi, Francesco, Bellani, Giacomo, and Bonanomi, Ezio

Abstract

This report describes the successful use of a new intervention to improve respiratory mechanics and gas exchange in a relatively homogeneous group of infants with severe bronchiolitis-induced PARDS after failure of conventional treatment. These results may open a new interesting area of research and management for PARDS patients.

Published
2018

47. Atypical presentation of pediatric BRAF RASopathy with acute encephalopathy

Author

Pezzani, Lidia, primary, Marchetti, Daniela, additional, Cereda, Anna, additional, Caffi, Lorella G., additional, Manara, Ornella, additional, Mamoli, Daniela, additional, Pezzoli, Laura, additional, Lincesso, Anna R., additional, Perego, Loredana, additional, Pellicioli, Isabella, additional, Bonanomi, Ezio, additional, Salvoni, Laura, additional, and Iascone, Maria, additional

Published
2018
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49. Coronary pathology of inherited generalized arterial calcification of infancy: a case report

Author

Federici, Duccio, primary, Torii, Sho, additional, Ciuffreda, Matteo, additional, Galletti, Lorenzo, additional, Lorini, Luca, additional, Bonanomi, Ezio, additional, Gianatti, Andrea, additional, Iascone, Maria, additional, Park, Joohyung, additional, Guo, Liang, additional, Romero, Maria E., additional, Kolodgie, Frank D., additional, Guagliumi, Giulio, additional, and Virmani, Renu, additional

Published
2018
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