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4. Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure

Author

Metra, M, Zacà, V, Agostoni, P, Bonadies, M, Ciccone, M, Cas, AD, Iacoviello, M, Lagioia, R, Lombardi, C, Maio, R, Magrì, D, Musca, G, Padeletti, M, Perticone, F, Pezzali, N, Piepoli, M, Sciacqua, A, Zanolla, L, Nodari, S, Filardi, PP, Dei Cas, L, on behalf of the Heart Failure Study Group of the Italian Society of Cardiology, PARATI, GIANFRANCO, Metra, M, Zacà, V, Parati, G, Agostoni, P, Bonadies, M, Ciccone, M, Dei Cas, A, Iacoviello, M, Lagioia, R, Lombardi, C, Maio, R, Magrì, M, Musca, G, Padeletti, M, Perticone, F, Pezzali, N, Piepoli, M, Sciacqua, A, Zanolla, L, Nodari, S, PERRONE FILARDI, Pasquale, Dei Cas, L., Cas, A, Magrì, D, Filardi, P, Dei Cas, L, and on behalf of the Heart Failure Study Group of the Italian Society of, C

Subjects
medicine.medical_specialty, Time Factors, Arterial disease, chronic heart failure, comorbidities, prognosis, therapy, Comorbidity, Disease, Risk Assessment, Coronary artery disease, Broad spectrum, Risk Factors, Internal medicine, medicine, Humans, In patient, chronic heart failure, comorbidities, therapy, prognosis, Heart Failure, business.industry, General Medicine, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Prognosis, medicine.disease, Cardiovascular Diseases, Heart failure, Concomitant, Chronic Disease, Disease Progression, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

A broad spectrum of concomitant disorders may complicate heart failure adding further morbidity and mortality risk. Comorbidities may be subdivided into cardiovascular and noncardiovascular. The first group includes hypertension, coronary artery disease, peripheral artery disease, cerebrovascular disease, arrhythmias and valvular heart disease. Noncardiovascular comorbidities include respiratory, endocrine, metabolic, nutritional, renal, hematopoietic, neurological as well as musculoskeletal conditions. In recent years, advances in the treatment of heart failure have not been attended by important changes in management of its comorbidities. They now seem to be major causes of the poor prognosis of heart failure patients. In this review we provide an updated summary of the epidemiological, pathophysiological and clinical characteristics of comorbidities as well as their potential impact for heart failure treatment.

Published
2011

21. Poster session IV * Friday 10 December 2010, 14:00-18:00

Author

Mora, B., primary, Base, E., additional, Schmid, W., additional, Andreas, M., additional, Weber, U., additional, Junreitmaier, M., additional, Foerster, F., additional, Hiesmayr, M., additional, Tschernich, H. D., additional, Guldbrand, D., additional, Goetzsche, O., additional, Eika, B., additional, Fumagalli, S., additional, Francini, S., additional, Gabbai, D., additional, Pedri, S., additional, Casalone Rinaldi, M., additional, Makhanian, Y., additional, Sollami, R., additional, Tarantini, F., additional, Marchionni, N., additional, Azcarate, P. M., additional, Castano, S., additional, Rodriguez-Manero, M., additional, Arraiza, M., additional, Levy, B., additional, Barba, J., additional, Rabago, G., additional, Bastarrika, G., additional, Rus, H., additional, Radoi, M., additional, Ciurea, C., additional, Boda, D., additional, Erdei, T., additional, Denes, M., additional, Mihalcz, A., additional, Kardos, A., additional, Foldesi, C. S., additional, Temesvari, A., additional, Lengyel, M., additional, Cameli, M., additional, Lisi, M., additional, Righini, F., additional, Ballo, P., additional, Henein, M., additional, Mondillo, S., additional, Nistri, S., additional, Galderisi, M., additional, Ballo, P. C., additional, Pagliani, L., additional, Olivotto, I., additional, Santoro, A., additional, Papesso, B., additional, Innelli, P., additional, Cecchi, F., additional, Hristova, K., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Nesheva, N., additional, Ivanovic, B., additional, Tadic, M. T., additional, Simic, D. S., additional, Rao, C. M., additional, Aguglia, D., additional, Casciola, G., additional, Imbesi, C., additional, Marvelli, A., additional, Sgro, M., additional, Benedetto, D., additional, Tripepi, G., additional, Zoccali, C., additional, Benedetto, F. A., additional, Mantziari, L., additional, Kamperidis, V., additional, Damvopoulou, E., additional, Ventoulis, I., additional, Giannakoulas, G., additional, Paraskevaidis, S., additional, Vassilikos, V., additional, Karvounis, H., additional, Styliadis, I. H., additional, Sonder, T. K., additional, Loegstrup, B. B., additional, Lambrechtsen, J., additional, Van Bortel, L. M., additional, Segers, P., additional, Egstrup, K., additional, Tho, A., additional, Moceri, P., additional, Bertora, D., additional, Gibelin, P., additional, Cho, E. J., additional, Choi, K. Y., additional, Kim, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Park, C. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Donal, E., additional, Coquerel, N., additional, Bodi, S., additional, Thebault, C., additional, Kervio, G., additional, Carre, F., additional, Daly, M. J., additional, Fairley, S. L., additional, Doherty, R., additional, Ashfield, K., additional, Kirkpatrick, R., additional, Smith, B., additional, Buchanan, J., additional, Hill, L., additional, Dixon, L. J., additional, Rosca, M., additional, O' Connor, K., additional, Magne, J., additional, Romano, G., additional, Calin, A., additional, Popescu, B. A., additional, Beladan, C. C., additional, Pierard, L., additional, Ginghina, C., additional, Lancellotti, P., additional, Bochenek, T., additional, Wita, K., additional, Tabor, Z., additional, Grabka, M., additional, Elzbieciak, M., additional, Trusz-Gluza, M., additional, Moreau, O., additional, Leclercq, C., additional, Sahlen, A., additional, Shahgaldi, K., additional, Aminoff, A., additional, Aagaard, P., additional, Manouras, A., additional, Winter, R., additional, Ehrenborg, E., additional, Braunschweig, F., additional, Bedetti, G., additional, Gargani, L., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Zhang, J., additional, Zhang, H. B., additional, Duan, Y. Y., additional, Chen, L. L., additional, Li, J., additional, Liu, L. W., additional, Zhu, T., additional, Li, H. L., additional, Su, H. L., additional, Zhou, X. D., additional, Ruiz Ortiz, M., additional, Mesa Rubio, D., additional, Delgado Ortega, M., additional, Romo Penas, E., additional, Toledano Degado, F., additional, Leon Del Pino, C., additional, Lopez Aguilera, J., additional, Villanueva Fernandez, E., additional, Cejudo Diaz Del Campo, L., additional, Suarez De Lezo, J., additional, Abergel, E., additional, Simon, M., additional, Dehant, P., additional, Bogino, E., additional, Jimenez, M., additional, Verdier, J. C., additional, Chauvel, C., additional, Albertsen, A. E., additional, Nielsen, J. C., additional, Mortensen, P. T., additional, Egeblad, H., additional, Nasr, G. M., additional, Tawfik, S., additional, Omar, A., additional, Olofsson, M., additional, Boman, K., additional, Rezzoug, N., additional, Vaes, B., additional, Degryse, J., additional, Vanoverschelde, J.-L., additional, Pasquet, A. A., additional, Poggio, D., additional, Bonadies, M., additional, Pacher, V., additional, Mazzetti, S., additional, Grillo, M., additional, D'elia, E., additional, Khouri, T., additional, Specchia, G., additional, Mornos, C., additional, Rusinaru, D., additional, Cozma, D., additional, Ionac, A., additional, Petrescu, L., additional, Rotzak, R., additional, Rosenman, Y., additional, Patterson, R. D., additional, Ratnatheepan, S., additional, Bogle, R. G., additional, Goebel, B., additional, Gjesdal, O., additional, Kottke, D., additional, Otto, S., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. R., additional, Poerner, T. C., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Itou, N., additional, Ono, T., additional, Yamamoto, M., additional, Osaki, T., additional, Tsuchida, T., additional, Sugi, K., additional, Wolber, T., additional, Haegeli, L., additional, Huerlimann, D., additional, Brunckhorst, C., additional, Duru, F., additional, Wu, Z. M., additional, Shu, X. H., additional, Dong, L. L., additional, Fan, B., additional, Ge, J. B., additional, Greutmann, M., additional, Tobler, D., additional, Biaggi, P., additional, Mah, M., additional, Crean, A., additional, Oechslin, E. N., additional, Silversides, C. K., additional, Giusca, S., additional, Jurcut, R., additional, Ghiorghiu, I., additional, Coman, I. M., additional, Amzulescu, M., additional, Ionescu, R., additional, Delcroix, M., additional, Voigt, J. U., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Maceira Gonzalez, A. M., additional, Cosin-Sales, J., additional, Dalli, E., additional, Igual, B., additional, Monmeneu, J. V., additional, Lopez-Lereu, P., additional, Estornell, J., additional, Ruvira, J., additional, Sotillo, J., additional, Stevanovic, A., additional, Toncev, A., additional, Dimkovic, S., additional, Dekleva, M., additional, Paunovic, N., additional, Toncev, D., additional, Sekularac, N., additional, Yildirimturk, O., additional, Helvacioglu, F. F., additional, Tayyareci, Y., additional, Yurdakul, S., additional, Demiroglu, I. C. C., additional, Aytekin, S., additional, Pinedo Gago, M., additional, Amat Santos, I., additional, Revilla Orodea, A., additional, Lopez Diaz, J., additional, Arnold, R., additional, De La Fuente Galan, L., additional, Recio Platero, A., additional, Gomez Salvador, I., additional, Puerto Sanz, A., additional, San Roman Calvar, J. A., additional, Yotti, R., additional, Bermejo, J., additional, Mombiela, T., additional, Benito, Y., additional, Sanchez, P. L., additional, Solis, J., additional, Prieto, R., additional, Fernandez-Aviles, F., additional, Zilberszac, R., additional, Gabriel, H., additional, Graf, S., additional, Mundigler, G., additional, Maurer, G., additional, Rosenhek, R., additional, Zito, C., additional, Salvia, J., additional, Longordo, C., additional, Donato, D., additional, Alati, E., additional, Miceli, M., additional, Pardeo, A., additional, Arcidiaco, S., additional, Oreto, G., additional, Carerj, S., additional, Hadjimiltiades, S., additional, Sianos, G., additional, Anastasiadis, K., additional, Grosomanidis, V., additional, Efthimiadis, G., additional, Parcharidis, G., additional, Yousry, M., additional, Rickenlund, A., additional, Petrini, J., additional, Gustafsson, T., additional, Liska, J., additional, Hamsten, A., additional, Eriksson, P., additional, Franco-Cereceda, A., additional, Eriksson, M. J., additional, Caidahl, K., additional, Mizia-Stec, K., additional, Pysz, P., additional, Jasinski, M., additional, Drzewiecka-Gerber, A., additional, Krejca, M., additional, Bochenek, A., additional, Wos, S., additional, Gasior, Z., additional, Tendera, M., additional, Niki, K., additional, Sugawara, M., additional, Takamisawa, I., additional, Watanabe, H., additional, Sumiyoshi, T., additional, Hosoda, S., additional, Ida, T., additional, Takanashi, S., additional, Olsen, N. T., additional, Sogaard, P., additional, Jons, C., additional, Mogelvang, R., additional, Larsson, H. B. W., additional, Goetze, J. P., additional, Nielsen, O. W., additional, Fritz-Hansen, T., additional, Sayar, N., additional, Orhan, A. L., additional, Erer, H. B., additional, Eren, M., additional, Atmaca, H., additional, Yilmaz, H. Y., additional, Cakmak, N., additional, Altay, S., additional, Terzi, S., additional, Yesilcimen, K., additional, Garcia Orta, R., additional, Moreno, E., additional, Lopez, M., additional, Uribe, I., additional, Vidal, M., additional, Ruiz-Lopez, M. F., additional, Gonzalez-Molina, M., additional, Oyonarte, J. M., additional, Lopez, S., additional, Azpitarte, J., additional, Szymanski, C., additional, Levine, R. A., additional, Zheng, H., additional, Handschumacher, M. D., additional, Tawakol, A., additional, Hung, J., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Tribouilloy, C., additional, Grigioni, F., additional, Avierinos, J.-F., additional, Barbieri, A., additional, Buiciuc, O., additional, Enriquez-Sarano, M., additional, Said, K., additional, Farag, A. K., additional, El-Ramly, M., additional, Rizk, H., additional, Iorio, A., additional, Pinamonti, B., additional, Bobbo, M., additional, Merlo, M., additional, Massa, L., additional, Faganello, G., additional, Di Lenarda, A., additional, Sinagra, G., additional, Margato, R., additional, Ribeiro, H., additional, Ferreira, C., additional, Matias, A., additional, Fontes, P., additional, Moreira, J. I., additional, Milan, A., additional, Puglisi, E., additional, Magnino, C., additional, Fabbri, A., additional, Leone, D., additional, Vairo, A., additional, Crudo, V., additional, Iannaccone, A., additional, Milazzo, V., additional, Veglio, F., additional, Maroz-Vadalazhskaya, N., additional, Ostrovskiy, I., additional, Imbalzano, E., additional, Saitta, A., additional, Cusma-Piccione, M., additional, Di Bella, G., additional, Nava, R., additional, Ferro, M., additional, Falanga, G., additional, Frigy, A., additional, Buzogany, J., additional, Szabados, C. S., additional, Dan, L., additional, Carasca, E., additional, Ikonomidis, I., additional, Lekakis, J., additional, Tzortzis, S., additional, Kremastinos, D. T., additional, Papadopoulos, C., additional, Paraskevaidis, I., additional, Triantafyllidi, H., additional, Trivilou, P., additional, Venetsanou, K., additional, Anastasiou-Nana, M., additional, Wierzbowska-Drabik, K., additional, Kurpesa, M., additional, Trzos, E., additional, Rechcinski, T., additional, Mozdzan, M., additional, Kasprzak, J. D., additional, Kosmala, W., additional, Kotwica, T., additional, Przewlocka-Kosmala, M., additional, Mysiak, A., additional, Skultetyova, D., additional, Filipova, S., additional, Chnupa, P., additional, Pechlivanidis, G., additional, Dimitroula, H., additional, Tsai, W.-C., additional, Liu, Y.-W., additional, Lin, C.-C., additional, Huang, Y.-Y., additional, Tsai, L.-M., additional, Park, S. M., additional, Kim, Y. H., additional, Shin, S. M., additional, Shim, W. J., additional, Gonzalez Mansilla, A., additional, Torres Macho, J., additional, Sanchez Sanchez, V., additional, Diez, P., additional, Delgado, J., additional, Borruel, S., additional, Saenz De La Calzada, C., additional, Pyxaras, S., additional, Valentincic, M., additional, Barbati, G., additional, Lo Giudice, F., additional, Perkan, A., additional, Magnani, S., additional, Palecek, T., additional, Ambroz, D., additional, Jansa, P., additional, Lindner, J., additional, Vitovec, M., additional, Polacek, P., additional, Jiratova, K., additional, Linhart, A., additional, Baskurt, M., additional, Dogan, G. M., additional, Abaci, O., additional, Kaya, A., additional, Kucukoglu, S., additional, Duszanska, A., additional, Kukulski, T., additional, Skoczylas, I., additional, Majsnerowska, A., additional, Nowowiejska-Wiewiora, A., additional, Streb, W., additional, Szulik, M., additional, Polonski, L., additional, Kalarus, Z., additional, Yerly, P. O., additional, Prella, M., additional, Joly, A., additional, Nicod, L., additional, Aubert, J. D., additional, Aebischer, N., additional, Dores, H., additional, Leal, S., additional, Rosario, I., additional, Correia, M. J., additional, Monge, J., additional, Grilo, A. M., additional, Arroja, I., additional, Fonseca, C., additional, Aleixo, A., additional, Silva, A., additional, Perez-David, E., additional, Sanchez-Alegre, M., additional, Gomez Anta, I., additional, De La Torre, J., additional, Alarcon, J., additional, Garcia Robles, J. A., additional, Lafuente, J., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Gonzalez Guardia, A., additional, Nunez, R., additional, Bosch Carabante, C., additional, Mateu, L., additional, Gual Capllonch, F., additional, Ferrer Sistach, E., additional, Lopez Ayerbe, J., additional, Bayes Genis, A., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Bramos, D., additional, Kalantaridou, A., additional, Takos, D., additional, Skaltsiotis, E., additional, Trika, C., additional, Tsirikos, N., additional, Pamboukas, C., additional, Kottis, G., additional, Toumanidis, S., additional, Aggeli, C., additional, Felekos, I., additional, Roussakis, G., additional, Kazazaki, C., additional, Lampropoulos, K., additional, Lagoudakou, S., additional, Stergiou, C., additional, Pitsavos, C., additional, Stefanadis, C., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Tanaka, T., additional, Uchida, K., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Abrahamsson, A., additional, Gudmundsson, P., additional, Brodin, L., additional, Knebel, F., additional, Schattke, S., additional, Sanad, W., additional, Schimke, I., additional, Schroeckh, S., additional, Brechtel, L., additional, Lock, J., additional, Makauskiene, R., additional, Baumann, G., additional, Borges, A. C., additional, Moelmen-Hansen, H. E., additional, Wisloff, U., additional, Aamot, I. L., additional, Stoylen, A., additional, Ingul, C. B., additional, Estensen, M.-E., additional, Beitnes, J. O., additional, Grindheim, G., additional, Henriksen, T., additional, Aaberge, L., additional, Smiseth, O. A., additional, Gullestad, L., additional, Aakhus, S., additional, Agoston, G., additional, Moggi Pignone, A., additional, Capati, E., additional, Badano, L., additional, Moreo, A., additional, Bombardieri, S., additional, Varga, A., additional, Carrideo, M., additional, Faricelli, S., additional, Corazzini, A., additional, Ippedico, R., additional, Ruggieri, B., additional, Di Blasio, A., additional, D'angelo, E., additional, Di Baldassarre, A., additional, Ripari, P., additional, Gallina, S., additional, Kentrschynskyj, A., additional, Hylander, B., additional, Jacobson, S., additional, Pagels, A., additional, Dumitrescu, S. I., additional, Tintoiu, I., additional, Greere, V., additional, Cristian, G., additional, Chiriac, L., additional, Pinte, F., additional, Droc, I., additional, Neagoe, G., additional, Stanciu, S., additional, Voicu, V. A., additional, Kuch-Wocial, A., additional, Pruszczyk, P., additional, Szmigielski, C. A., additional, Szulc, M., additional, Styczynski, G., additional, Sinski, M., additional, Kaczynska, A., additional, Ryabikov, A., additional, Malyutina, S., additional, Halcox, J., additional, Bobak, M., additional, Nikitin, Y. U., additional, Marmot, M., additional, Barbosa, D., additional, Kiss, G., additional, Orderud, F., additional, Amundsen, B., additional, Jasaityte, R., additional, Loeckx, D., additional, Claus, P., additional, Torp, H., additional, D'hooge, J., additional, Kuhl, J. T., additional, Lonborg, J., additional, Fuchs, A., additional, Andersen, M., additional, Vejlstrup, N., additional, Engstrom, T., additional, Moller, J. E., additional, Kofoed, K. F., additional, Smith, L. A., additional, Bhan, A., additional, Paul, M., additional, Monaghan, M. J., additional, Zaborska, B., additional, Stec, S., additional, Sikora-Frac, M., additional, Krynski, T., additional, Kulakowski, P., additional, Pushparajah, K., additional, Dashwood, D., additional, Barlow, A., additional, Nugent, K., additional, Miller, O., additional, Simpson, J., additional, Valeur, N., additional, Ersboll, M. K., additional, Kjaergaard, J., additional, Greibe, R., additional, Risum, N., additional, Hassager, C., additional, Kober, L., additional, Popovic, D., additional, Nedeljkovic, I., additional, Petrovic, M., additional, Vujisic-Tesic, B., additional, Arandjelovic, A., additional, Stojiljkovic, S., additional, Jakovljevic, B., additional, Damjanovic, S., additional, Ostojic, M., additional, Agrios, I. A., additional, Bramos, D. B., additional, Skaltsiotis, H. S., additional, Takos, D. T., additional, Kaladaridis, A., additional, Vasiladiotis, N. V., additional, Kottis, G. K., additional, Antoniou, A. A., additional, Pamboucas, C. P., additional, Toumanidis, S. T. T., additional, Locorotondo, G., additional, Porto, I., additional, Paraggio, L., additional, Fedele, E., additional, Barchetta, S., additional, De Caterina, A. R., additional, Rebuzzi, A. G., additional, Crea, F., additional, Galiuto, L., additional, Lipiec, P., additional, Szymczyk, E., additional, Michalski, B., additional, Wozniakowski, B., additional, Stefanczyk, L., additional, Rotkiewicz, A., additional, Shim, A., additional, Vainer, J., additional, Habets, J., additional, Lousberg, A., additional, Pont De, C., additional, Waltenberger, J., additional, Farouk, H., additional, Heshmat, H., additional, Adel, A., additional, El Chilali, K., additional, Baghdady, Y., additional, Sorour, K., additional, Gustafsson, U., additional, Larsson, M., additional, Bjallmark, A., additional, Lindqvist, P., additional, A'roch, R., additional, Haney, M., additional, Waldenstrom, A., additional, Mladenovic, Z., additional, Tavciovski, D., additional, Mijailovic, Z., additional, Djordjevic - Dikic, A., additional, Obradovic, S., additional, Matunovic, R., additional, Jovic, Z., additional, Djuric, P., additional, Aase, S., additional, Dalen, H., additional, Sarkola, T., additional, Redington, A. N., additional, Keeley, F., additional, Bradley, T., additional, Jaeggi, E., additional, and Sahlen, H., additional

Published
2010
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23. THERMOELASTIC STRESS ANALYSIS FOR LINEAR ELASTIC BODIES.

Author

İnan, Esin, Kırış, Ahmet, Ivanova, J., Bontcheva, N., Pastrone, F., and Bonadies, M.

Abstract

The stress analysis for elastic cylinders made of polymethylmethacrylate (PMMA) under cyclic loading is provided by using FEM. Under the assumption that the elastic moduli depend linearly on the temperature, new fomulae, generalizing the well known Kelvin's formula, are given such that we can estimate the temperature variation on the external surface of a homogeneous ideal cylinder. Using suitable numerical methods we obtain theoretical results which fit the experimental values for the temperature variation [ABSTRACT FROM AUTHOR]

Published
2006
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26. Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery.

Author

Briguglio M, Gianturco L, Stella D, Colombo C, Bonadies M, Sala O, Anselmi M, Banfi G, and Turiel M

Abstract

Background: Cardiovascular diseases and insufficient levels of vitamin D are risk factors for adverse surgical outcomes, and they are both commonly present among older adults undergoing orthopaedic surgery. Giving the cardiovascular effects of vitamin D, pre-operative diagnosis of hypovitaminosis D would be a valuable step for the implementation of supplementation protocols. We investigated if the normalization of serum 25 [OH] D could ameliorate cardiac performance of older adults suffering from cardiovascular diseases., Methods: We enrolled 47 older adults scheduled for major orthopaedic surgery and suffering from hypovitaminosis D. Patients underwent 6-months calcifediol supplementation with a starting dose at first post-operative day of 50 µg/die in liquid preparation. Down-titration to 20 µg/die at 3-months assessment was planned. Cardiac performance was evaluated by measuring left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) during pre-operative assessments and at 1-month, 3-months, 6-months follow-ups., Results: Six months of calcifediol supplementation were associated with a significant improvement of both LVEF (+ 3.94%; 95% CI: -4.0789 to -0.8232; P < 0.01) and GLS (+ 18.56%; Z = -5.895; P < 0.0001)., Conclusions: Calcifediol supplementation normalized serum 25 [OH] D concentration after 1-month treatment. GLS offered better insights into myocardial contractile amelioration than LVEF, thus being useful for detecting earlier subclinical changes that may anticipate hemodynamic modifications.

Published
2018
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27. Neutrophil gelatinase-associated lipocalin predicts worsening of renal function in acute heart failure: methodological and clinical issues.

Author

Mortara A, Bonadies M, Mazzetti S, Fracchioni I, Delfino P, Chioffi M, Bersano C, and Specchia G

Subjects
Acute-Phase Proteins, Aged, Biomarkers blood, C-Reactive Protein analysis, Cardio-Renal Syndrome diagnosis, Creatinine analysis, Female, Glomerular Filtration Rate, Hemoglobins analysis, Hospitalization, Humans, Lipocalin-2, Male, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index, Cardio-Renal Syndrome blood, Heart Failure epidemiology, Lipocalins blood, Proto-Oncogene Proteins blood
Abstract

Background: Worsening of renal function (WRF) in acute heart failure (AHF) strongly predicts adverse clinical outcome. Plasma neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as an earlier biomarker of tubular damage, but important methodological issues remain unsolved, particularly in AHF., Methods and Results: In 30 consecutive patients admitted for AHF, 108 serum NGAL (Alere system) measurements were performed at entry and in the first days of recovery, and reproducibility within the same blood samples was very high (r = 0.98). NGAL at entry was related to kidney function [r = 0.51 vs. creatinine (Cr) and r = -0.49 vs. estimated glomerular filtration rate (eGFR), both P < 0.001], and weakly with hemoglobin (r = -0.36, P < 0.05) and C-reactive protein (CRP) (r = 0.26, P < 0.05). During hospitalization, WRF occurred in 26.7% of the patients. Baseline NGAL was only slightly higher in patients who developed WRF as compared to those who did not (151 ± 90 vs. 119 ± 75 ng/ml, NS), but it increased significantly in the following days, always preceding WRF occurrence (max. previous 24 h, average 95%, range 25-200%). The area under the Receiver Operating Characteristic (ROC) curve (AUC-ROC) was 0.69 for pathological NGAL at entry and 0.91 for delta NGAL changes during the first days., Conclusions: In patients with AHF, serum NGAL measurement is highly reproducible and at entry it is related to baseline Cr and eGFR, but does not predict WRF during subsequent hospitalization. On the contrary, serial measurements of NGAL in the first days of hospitalization can accurately predict WRF.

Published
2013
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28. Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure.

Author

Metra M, Zacà V, Parati G, Agostoni P, Bonadies M, Ciccone M, Cas AD, Iacoviello M, Lagioia R, Lombardi C, Maio R, Magrì D, Musca G, Padeletti M, Perticone F, Pezzali N, Piepoli M, Sciacqua A, Zanolla L, Nodari S, Filardi PP, and Dei Cas L

Subjects
Chronic Disease, Comorbidity, Disease Progression, Heart Failure therapy, Humans, Prognosis, Risk Assessment, Risk Factors, Time Factors, Cardiovascular Diseases epidemiology, Heart Failure epidemiology
Abstract

A broad spectrum of concomitant disorders may complicate heart failure adding further morbidity and mortality risk. Comorbidities may be subdivided into cardiovascular and noncardiovascular. The first group includes hypertension, coronary artery disease, peripheral artery disease, cerebrovascular disease, arrhythmias and valvular heart disease. Noncardiovascular comorbidities include respiratory, endocrine, metabolic, nutritional, renal, hematopoietic, neurological as well as musculoskeletal conditions. In recent years, advances in the treatment of heart failure have not been attended by important changes in management of its comorbidities. They now seem to be major causes of the poor prognosis of heart failure patients. In this review we provide an updated summary of the epidemiological, pathophysiological and clinical characteristics of comorbidities as well as their potential impact for heart failure treatment., (2011 Italian Federation of Cardiology.)

Published
2011
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29. Three years of cardiac resynchronization therapy: could superior benefits be obtained in patients with heart failure and narrow QRS?

Author

Gasparini M, Regoli F, Galimberti P, Ceriotti C, Bonadies M, Mangiavacchi M, Andreuzzi B, Bragato R, Pini D, Klersy C, and Gronda E

Subjects
Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pacemaker, Artificial, Prospective Studies, Treatment Outcome, Ventricular Dysfunction, Left, Cardiac Pacing, Artificial, Electrocardiography, Heart Failure therapy
Abstract

Aim of the Study: To examine the long-term effects of cardiac resynchronization therapy (CRT) in patients presenting with heart failure (HF) and QRS 120 ms in the remaining 331 patients. The baseline characteristics of the 2 groups were similar. We evaluated indices of cardiac function, percentage of responders, and survival rates over a mean 28-month follow-up., Results: Both groups experienced similar long-term increases in 6-MHW, and decreases in New York Heart Association functional class and LV end-systolic volume (all comparisons P < 0.0001 in both groups). Time interaction of changes in LVEF and percentage of responders were significantly different (P = 0.03 and P = 0.004, respectively), in favor of the narrow QRS group, where the changes were sustained and persisted at 2 and 3 years. The long-term death rate from HF was lower in the group with narrow than in the group with wide QRS complex (P = 0.04; log-rank test)., Conclusions: CRT confers considerable long-term clinical, functional, and survival benefits in patients presenting with HF and narrow QRS, not preselected by echocardiographic criteria of dyssynchrony. Caution is advised before denying CRT to these patients on the basis of QRS width only.

Published
2007
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30. [Psychological characteristics of patients with vasovagal syncope: and observational study on sixty subjects].

Author

Bonadies M, Di Trani M, Solano L, Tumbiolo F, Piacentini F, and Ammirati F

Subjects
Adult, Affective Symptoms diagnosis, Chi-Square Distribution, Data Interpretation, Statistical, Education, Emotions, Female, Humans, Life Change Events, Male, Psychological Tests, Surveys and Questionnaires, Syncope, Vasovagal psychology
Abstract

Background: Based on the relevant literature, the aim of this study was to analyze the psychosocial characteristics of patients with vasovagal syncope and to evaluate these factors as possible etiopathological components., Methods: The study sample consisted of 60 subjects divided as follows: the syncope group (n = 30) and the control group (n = 30, without prominent diseases). The two groups were matched with regard to age, sex, education and civil status. Each participant filled in the Twenty-Item Toronto Alexithymia Scale, acceptance of emotions scale, profile of mood state, attachment style questionnaire, and childhood traumatic events scale., Results: The syncope group showed a higher number of somatic diseases (p < 0.0002) and a higher drug use (p < 0.0001) than the control group. Moreover, the syncope group showed higher scores at the childhood traumatic events scale (p < 0.04) and more difficulties in emotion regulation (p < 0.02). The syncope group also showed higher scores at the need for approval scale (p < 0.0006) and lower scores at the confidence scale (p < 0.02) of the attachment style questionnaire, which reflect an insecure style of relationship with others., Conclusions: A high number of traumatic events in infancy and adolescence, difficulties in the expression of emotions and an insecure style of relationship seem to characterize subjects with vasovagal syncope. These data show that syncope could be at least partiality due to a relational and emotional imbalance that finds expression through the body in the presence of insufficient mental processing. Treatment of this syndrome should therefore take these aspects into consideration.

Published
2006

31. Delayed defibrillation testing in patients implanted with biventricular ICD (CRT-D): a reliable and safe approach.

Author

Gasparini M, Galimberti P, Regoli F, Ceriotti C, and Bonadies M

Subjects
Acute Disease, Aged, Feasibility Studies, Female, Humans, Male, Middle Aged, Safety, Time Factors, Cardiac Pacing, Artificial adverse effects, Defibrillators, Implantable adverse effects, Electric Countershock instrumentation, Heart Failure therapy, Heart Ventricles physiopathology
Abstract

Background: Defibrillation testing (DT) at the end of the implantation of cardiac resynchronization pacemaker with a defibrillator (CRT-D) exposes heart failure (HF) patients to increased procedural risks. However, until now, delayed DT has not been assessed as a possible option in HF patients implanted with CRT-D., Objective: Aim of the present study is to assess safety and feasibility of delayed DT in HF patients treated with CRT-D., Material and Methods: Two hundred and eleven consecutive patients (mean age: 65 years, mean NYHA class 3.0, mean EF: 29.3%) underwent CRT-D implantation from October 1999 to December 2004. In the first 17 patients, DT was performed at the end of CRT-D implantation. In the other 194 consecutive patients, DT was performed at 2 months after CRT-D implantation. Outcome of DT, as well as "acute" LV lead dislodgment rate were evaluated in the latter group of 194 patients undergoing a delayed DT. Also, ICD function was assessed through device telemetry analysis at 2 months., Results: At delayed DT, first shock was effective in 187 of 194 patients (96%), ineffective VF interruption at maximum energy occurred only in one patient (0.5%), and acute LV lead dislodgment was 1%. No ICD therapy failure occurred in the 2-month untested period., Conclusion: DT performed 2 months after CRT-D implantation is safe and feasible; this is possibly related to the improvement of clinical conditions and hemodynamic status as well as greater lead stability 2 months after CRT-D.

Published
2005
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