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202 results on '"Bonadei, I."'

12. Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors

Author

Cavazzana, I, primary, Piantoni, S, additional, Sciatti, E, additional, Fredi, M, additional, Taraborelli, M, additional, Bonadei, I, additional, Airò, P, additional, Metra, M, additional, Tincani, A, additional, Franceschini, F, additional, and Vizzardi, E, additional

Published
2019
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15. Cardiopoietic cell therapy for advanced ischemic heart failure : results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Author

Bartunek, Jozef, Terzic, Andre, Davison, Beth A, Filippatos, Gerasimos S, Radovanovic, Slavica, Beleslin, Branko, Merkely, Bela, Musialek, Piotr, Wojakowski, Wojciech, Andreka, Peter, Horvath, Ivan G, Katz, Amos, Dolatabadi, Dariouch, El Nakadi, Badih, Arandjelovic, Aleksandra, Edes, Istvan, Seferovic, Petar M, Obradovic, Slobodan, Vanderheyden, Marc, Jagic, Nikola, Petrov, Ivo, Atar, Shaul, Halabi, Majdi, Gelev, Valeri L, Shochat, Michael K, Kasprzak, Jaroslaw D, Sanz Ruiz, Ricardo, Heyndrickx, Guy R, Nyolczas, Noémi, Legrand, Victor, Guédès, Antoine, Heyse, Alex, Moccetti, Tiziano, Fernandez Aviles, Francisco, Jimenez Quevedo, Pilar, Bayes Genis, Antoni, Hernandez Garcia, Jose Maria, Ribichini, Flavio, Gruchala, Marcin, Waldman, Scott A, Teerlink, John R, Gersh, Bernard J, Povsic, Thomas J, Henry, Timothy D, Metra, Marco, Hajjar, Roger J, Tendera, Michal, Behfar, Atta, Alexandre, Bertrand, Seron, Aymeric, Stough, Wendy Gattis, Sherman, Warren, Cotter, Gad, Wijns, W. i. l. l. i. a. m. Collaborators Clinical investigators, Dens, sites Belgium: Ziekenhuis Oost Limburg: J., Dupont, M., Mullens, W., Janssens, M., Dolatabadi, Hoˆpital Civil de Charleroi: D., De Bruyne, Y., Lalmand, J., Dubois, P., El Nakadi, B., Aminian, A., De Vuyst, E., Gurnet, P., Gujic, M., Blankoff, I., Guedes, CHU Mont Godinne UCL: A., Gabriel, L., Seldrum, S., Doyen, C., Andre´, M., Heyse, AZ Glorieux: A., Van Durme, F., Verschuere, J., Legrand, Domaine Universitaire du Sart Tilman: V., Gach, O., D’Orio, V., Davin, L., Lancellotti, P., Baudoux, E., Ancion, A., Dulgheru, R., Vanderheyden, OLV Ziekenhuis Aalst – Cardiologie: M., Bartunek, J., Wijns, W., Verstreken, S., Penicka, . M., Gelev, P. Meeus Bulgaria: Tokuda Hospital Sofia: V., Zheleva Kichukova, I., Parapunova, R., Melamed, R., Sardovski, S., Radev, O., Yordanov, A., Radinov, A., Nenov, D., Amine, I., Petrov, City Hospital Clinic Cardiology Center: I., Kichukov, K., Nikitasov, L., Stankov, Z., Stoyanov, H., Tasheva Dimitrova, I., Angelova, M., Dimitrov, E., Minchev, M., Garvanski, I., Botev, C., Polomski, P., Alexandrovska University Hospital, Vassilev, Sofia: D., Karamfiloff, K., Tarnovska Kadreva, R., Vladimirova, L., Dimitrov, G., Hadzhiev, E., Tzvetkova, G., Andreka, . M. Atanasova Hungary: Gottsegen Gyo¨ rgy Orszagos Kardiologiai Inte´zet: P., Fontos, G., Fabian, J., Csepregi, A., Uzonyi, G., Gelei, A., Edes, Debreceni Egyetem Orvos e´s Ege´szse´gtudomanyi Centrum Altalanos Orvostudomanyi Kar Kardiologia Inte´zet: I., Balogh, L., Vajda, G., Darago, A., Gergely, S., Fulop, T., Jenei, C., Horvath, Pe´csi Tudomanyegyetem Klinikai Ko¨zpont Szıvgyogyaszati Klinika: I., Magyari, B., Nagy, A., Cziraki, A., Faludi, R., Kittka, B., Alizadeh, H., Merkely, Semmelweis Egyetem Varosmajori Szıv e´s Ergyogyaszati Klinika: B., Geller, L., Farkas, P., Szombath, G., Foldes, G., Skopal, J., Kovacs, A., Kosztin, A., Gara, E., Sydo, N., Nyolczas, MH Ege´szse´gu¨gyi Ko¨zpont Kardiologiai Osztaly: N., Kerecsen, G., Korda, A., Kiss, . M., Borsanyi, T., Polgar, B., Muk, B., Sharif, Z. Bari Ireland: HRB Clinical Research Facility: F., Atar, Y. M. Smyth Israel:Western Galilee Hospital: S., Shturman, A., Akria, L., Kilimnik, M., Brezins, M., Halabi, Ziv Medical Center: M., Dally, N., Goldberg, A., Aehab, K., Rosenfeld, I., Levinas, T., Saleem, D., Katz, Barzilai Medical Center: A., Plaev, T., Drogenikov, T., Nemetz, A., Barshay, Y., Jafari, J., Orlov, I., Nazareth Hospital EMMS: M. Omory, N. Kogan Nielsen, Shochat, Hillel Yaffe Medical Center: M., Shotan, A., Frimerman, A., Meisel, S., Asif, A., Sofer, O., Blondheim, D. S., Vazan, A., Metra, L. Arobov Italy: A. O. Spedali Civili di Brescia: M., Bonadei, I., Inama, L., Chiari, E., Lombardi, C., Magatelli, M., Russo, D., Lazzarini, V., Carubelli, V., Vassanelli, AOUI Verona – Borgo Trento Hospital: C., Ribichini, Flavio Luciano, Bergamini, C., Krampera, Mauro, Cicoria, M. A., Zanolla, L., Dalla Mura, D., Gambaro, A., Rossi, A., Pesarini Poland: Jagiellonian University Department of Cardiac, G., Musialek, Vascular Diseases at John Paul II Hospital in Krakow: P., Mazurek, A., Drabik, L., Ka˛dzielski, A., Walter, Z., Dzieciuch Rojek, M., Rubis, P., Plazak, . W., Tekieli, L., Podolec, J., Orczyk, W., Sutor, U., Zmudka, K., Olszowska, M., Podolec, P., Gruchala, Uniwersyteckie Centrum Kliniczne: M., Ciecwierz, D., Mielczarek, M., Burakowski, S., Chmielecki, M., Zielinska, M., Frankiewicz, A., Wdowczyk, J., Stopczynska, I., Bellwon, J., Mosakowska, K., Nadolna, R., Wroblewska, J., Rozmyslowska, M., Rynkiewicz, M., Marciniak, I., Raczak, G., Tarnawska, M., Taszner, M., Kasprzak, Bieganski Hospital: J., Plewka, M., Fiutowska, D., Rechcinski, T., Lipiec, P., Sobczak, M., Weijner Mik, P., Wraga, M., Krecki, R., Markiewicz, M., Haval Qawoq, D., Wojakowski, Gornosla˛skie Centrum Medyczne Sla˛skie j. Akademii Medycznej: W., Ciosek, J., Dworowy, S., Gaszewska Zurek, E., Ochala, A., Cybulski, W., Jadczyk, T., Wanha, W., Parma, Z., Kozlowski, M., Dzierzak, M., Markiewicz Serbia: Clinical Hospital Center Zvezdara, M., Arandjelovic, Cardiology Clinic: A., Sekularac, N., Boljevic, D., Bogdanovic, A., Zivkovic, S., Cvetinovic, N., Loncar, G., Clinical Centre of Serbia, Beleslin, Cardiology Clinic: B., Nedeljkovic, M., Trifunovic, D., Giga, V., Banovic, M., Nedeljkovic, I., Stepanovic, J., Vukcevic, V., Djordjevic Dikic, A., Dobric, M., Obrenovic Kircanski, B., Seferovic, Cardiology Clinic: P., Orlic, D., Tesic, M., Petrovic, O., Milinkovic, I., Simeunovic, D., Jagic, Clinical Center of Kragujevac: N., Tasic, M., Nikolic, D., Miloradovic, V., Djurdjevic, P., Sreckovic, M., Zornic, N., Clinical Hospital Center Bezanijska Kosa, Radovanovic, Cardiology Department: S., Saric, J., Hinic, S., Djokovic, A., Ðordevic, S., Bisenic, V., Markovic, O., Stamenkovic, S., Malenkovic, V., Tresnjak, J., Misic, G., Cotra, D., Tomovic, L., Vuckovic, V., Clinic of Emergency Internal Medicine, Obradovic, Military Medical Academy: S., Jovic, Z., Vukotic, S., Markovic, D., Djenic, N., Ristic Andjelkov, A., Bayes Genis, D. Ljubinka Spain: Hospital Universitario Germans Trias I. Pujol: A., Rodriguez Leor, O., Labata, C., Vallejo, N., Ferrer, E., Batlle, M., Fernandez Aviles, Hospital General Universitario Gregorio Mara~non: F., Sanz Ruiz, R., Casado, A., Loughlin, G., Zatarain, E., Anguita, J., Ferna ndez Santos, M. E., Pascual, C., Bermejo, J., Hernandez Garcia, Hospital Clinico Universitario Virgen de la Victoria: J. M., Jimenez Navarro, M., Dominguez, A., Carrasco, F., Mu~noz, A., Garcia Pinilla, J. M., Ruiz, J., Queipo de Llano, M. P., Hernandez, A., Fernandez, A., Jimenez Quevedo, Hospital Clinico San Carlos: P., Guerra, R., Biagioni, C., Gonzalez, R. A., Gomez deDiego, J. J., Mansson Broberg, L. Perez de Isla Sweden: Karolinska University Hospital: A., Sylve´n, C., Leblanc, K., Winter, R., Blomberg, P., Gunyeli, E., Ruck, A., Silva, C., Fo¨rstedt Switzerland: CardioCentro Ticino, J., Moccetti, Switzerland: T., Rossi, M., Pasotti, E., Petrova, I., Crljenica, C., Monti, C., Murzilli, R., Su¨rder, D., Moccetti, M., Turchetto, L., Locicero, V., Chiumiento, L., Maspoli, S., Mombelli, M., Anesini, A., Biggiogero, M., Ponti, G., Camporini, C., Polledri, S., Hill, G. Dolci United Kingdom: Kings College Hospital: J., Plymen, C., Amin Youssef, G., Mcdonagh, T., Drasar, E., Mijovic, A., Jouhra, F., Mcloman, D., Dworakowski, R., Webb, I., Byrne, J., and Potter, V.

Subjects
0301 basic medicine, Male, Cardiopoiesis, Cardiovascular disease, Disease severity, Marker, Precision medicine, Regenerative medicine, Stem cell, Target population, Adult, Aged, Double-Blind Method, Female, Heart Failure, Humans, Mesenchymal Stem Cell Transplantation, Middle Aged, Myocardial Ischemia, Prospective Studies, Treatment Outcome, Young Adult, Cardiology and Cardiovascular Medicine, Cell- and Tissue-Based Therapy, mesenchymal stem-cells, 030204 cardiovascular system & hematology, Cardiorespiratory Medicine and Haematology, outcomes, Fast-Track Clinical Research, Sudden cardiac death, 0302 clinical medicine, Ischemia, cardiovascular disease, Clinical endpoint, target population, CHART Program, Ejection fraction, bone-marrow, Heart Failure/Cardiomyopathy, 3. Good health, Cohort, Cardiology, Fast Track, disease severity, delivery, medicine.medical_specialty, precision medicine, Clinical Sciences, regenerative medicine, 03 medical and health sciences, cardiopoiesis, Internal medicine, medicine, Adverse effect, marker, disease, business.industry, medicine.disease, mortality, Confidence interval, Clinical trial, stem cell, Editor's Choice, 030104 developmental biology, predictors, Cardiovascular System & Hematology, Heart failure, business
Abstract

Altres ajuts: This work was supported by Celyad, SA (Mont-Saint-Guibert, Belgium). Celyad has received research grants from the Walloon Region (Belgium, DG06 funding). Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischaemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion. Those achieving > 24 million mesenchymal stem cells (n = 315) were randomized to cardiopoietic cells delivered endomyocardially with a retention-enhanced catheter (n = 157) or sham procedure (n = 158). Procedures were performed as randomized in 271 patients (n = 120 cardiopoietic cells, n = 151 sham). The primary efficacy endpoint was a Finkelstein–Schoenfeld hierarchical composite (all-cause mortality, worsening heart failure, Minnesota Living with Heart Failure Questionnaire score, 6-min walk distance, left ventricular end-systolic volume, and ejection fraction) at 39 weeks. The primary outcome was neutral (Mann–Whitney estimator 0.54, 95% confidence interval [CI] 0.47–0.61 [value > 0.5 favours cell treatment], P = 0.27). Exploratory analyses suggested a benefit of cell treatment on the primary composite in patients with baseline left ventricular end-diastolic volume 200–370 mL (60% of patients) (Mann–Whitney estimator 0.61, 95% CI 0.52–0.70, P = 0.015). No difference was observed in serious adverse events. One (0.9%) cardiopoietic cell patient and 9 (5.4%) sham patients experienced aborted or sudden cardiac death. The primary endpoint was neutral, with safety demonstrated across the cohort. Further evaluation of cardiopoietic cell therapy in patients with elevated end-diastolic volume is warranted.

Published
2017

25. Role of the old and new echocardiographic technologies in cardiac resynchronization therapy

Author

Bonadei, I., Vizzardi, E., Gorga, E., Valentina Carubelli, Pagnoni, M., Sciatti, E., Raweh, A., Cerini, M., Bontempi, L., Curnis, A., and Metra, M.

Subjects
Cardiac Resynchronization Therapy, Heart Failure, Heart Diseases, Echocardiography, Humans, Cardiac Resynchronization Therapy Devices
Abstract

Cardiac resynchronization therapy (CRT) is an important tool for the treatment of patients with chronic heart failure, as it can correct the heterogeneity of regional left ventricular mechanical contraction, known as dyssynchrony. Although this therapy is strongly indicated in patients with both heart failure with left ventricular systolic dysfunction and wide Q-, R- and S-waves (QRS) on electrocardiogram, about one-third of these patients are non-responders. Since the degree of mechanical dyssynchrony can vary greatly, it is interesting to quantify dyssynchrony by means of imaging methods, such as echocardiography, which might be able to lead to a better selection of CRT candidates. This article will review the role of old and new echocardiographic techniques to predict CRT response.

Published
2016

29. P1138Cardiac shear wave velocity in healthy individualsP1139Do still we need E/E prime ratio in predicting left ventricular filling pressures in heart failure with reduced ejection fraction?P1140Evaluation of myocardial dysfunction in children with Beta Thalassemia majorP1141Association of left ventricular size and septal mechanics with right ventricular function and transplant-free survival in infants with hypoplastic left heart syndromeP1142Predictive value of speckle tracking of chronic rejection in middle-aged heart transplant patientsP1143Determinants of the left atrial stiffness in systemic sclerosisP1144Could right atrial peak global longitudinal strain be useful in assessment of right heart function in pulmonary arterial hypertension?P1145Utility of speckle tracked strain assessment of the right ventricle following lung resectionP1146Edge-to-edge-repair in patients with dilated cardiomyopathy and secondary mitral regurgitation: effect on myocardial function as assessed by echocardiographic speckle tracking analysisP1147Decongestion, arterial stiffness and ventricular-arterial coupling in AHFP1148Myocardial disfunction in Anderson-Fabry disease (AFD) without left ventricular hypertrophyP1149Assessment of left ventricular twist-untwist mechanics in cardiac amyloidosis using three-dimensional speckle-tracking echocardiographyP1150Three-dimensional principal strain analysis for the dependency of preload changes

Author

Strachinaru, M., primary, Romano, G., primary, Tantawy, AA., primary, Forsha, D., primary, Pavasini, R., primary, Porpaczy, A., primary, Kaznica-Wiatr, M., primary, Mccall, PJ., primary, Faber, L., primary, Sciatti, E., primary, Monte, IP., primary, Capotosto, L., primary, Park, CS., primary, Geleijnse, ML., additional, Bosch, JG., additional, De Jong, N., additional, Van Der Steen, AFW, additional, Van Dalen, BM., additional, Vos, HJ., additional, Magro, S., additional, Mina', C., additional, Novo, G., additional, Dell'oglio, S., additional, Falletta, C., additional, Di Gesaro, G., additional, Clemenza, F., additional, Bellavia, D., additional, Habeeb, N., additional, El Sherif, NHK, additional, Abdelhamid, AE., additional, Li, L., additional, Joseph, N., additional, Kutty, S., additional, Freidberg, MK., additional, Cirillo, C., additional, Mordi, I., additional, Grapsa, J., additional, Tzemos, N., additional, Nogradi, A., additional, Strenner, M., additional, Minier, T., additional, Czirjak, L., additional, Komocsi, A., additional, Faludi, R., additional, Nowacka, M., additional, Kopec, G., additional, Waligora, M., additional, Olszowska, M., additional, Podolec, P., additional, Sonecki, P., additional, Kinsella, J., additional, Shelley, BG., additional, Scholtz, S., additional, Dimitriadis, Z., additional, Graw, A., additional, Bogunovic, N., additional, Scholtz, W., additional, Boergermann, J., additional, Gummert, J., additional, Horstkotte, D., additional, Vizzardi, E., additional, Bonadei, I., additional, Platto, F., additional, Metra, M., additional, Bottari, VE., additional, Gentile, S., additional, Romano, C., additional, Rodolico, MS., additional, Losi, V., additional, Tamburino, C., additional, Ashurov, R., additional, Truscelli, G., additional, Placanica, G., additional, Lai, S., additional, Vitarelli, A., additional, Jeong, MH., additional, Ahn, HS., additional, Cho, JS., additional, and Youn, HJ., additional

Published
2016
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30. P594Contrast transthoracic echocardiography as a gatekeeper for patent foramen ovale closureP595Mitral annular displacement in apical four-chamber view by speckle-tracking echocardiography as a simple index for left ventricular longitudinal systolic functionP596Impact of chronic glycemic control on left ventricular myocardial function in young patients with type 1 diabetes mellitusP597Association of left atrial function echocardiographic parametres with fibrosis assesed invasively in patients with sinus rhythm and atrial fibrillation undergoing ablation for atrial fibrillationP598Mitral annular calcification decreases diastolic tissue Doppler velocity(E') in regions affected with calcificationsP5992D longitudinal LV speckle tracking strain pattern in breast cancer survivors: sports activity vs exercise as prescription modelP600Catheter related atrial fibrillation is associated with left atrial deformation in patients with paroxsymal supraventricular tachycardia: a study of two-dimensional speckle tracking echocardiographyP601Early radiotherapy-induced ecg changes and their comparison with echocardiography in breast cancer patientsP602Renal function is a major determinant of decreased sub-epicardial longitudinal strain in hypertensionP603Evaluation of left atrial function in patients with non valvular atrial fibrillation post cardioversion: speckle tracking echocardiographyP604Myocardial dysfunction in ANCA vasculitis measured by two-dimensional speckle tracking echocardiographyP605CRT, arterial stiffness and ventricular-arterial coupling in HFrEFP606Mitral annular morphology and function in cardiac amyloidosis as assessed by three-dimensional speckle tracking echocardiographyP607Coronary plaque characterization in Egyptian metabolic syndrome patients using 64-MDCT

Author

Muratori, M., primary, Hozumi, T., primary, Ruisanchez Villar, C., primary, Pilichowska, E., primary, Chebrolu, L., primary, Stefani, L., primary, Akcakoyun, M., primary, Keski-Pukkila, KT., primary, Li, W-H, primary, Khalil, W., primary, Bajrangee, A., primary, Sciatti, E., primary, Nemes, A., primary, Selim, EHAB, primary, Italiano, G., additional, Innocenti, E., additional, Fusini, L., additional, Mapelli, M., additional, Tamborini, G., additional, Ghulam Ali, S., additional, Gripari, P., additional, Maltagliati, A., additional, Celeste, F., additional, Pepi, M., additional, Emori, H., additional, Takemoto, K., additional, Terada, K., additional, Orii, M., additional, Ohkochi, K., additional, Kameyama, T., additional, Ozaki, Y., additional, Kuroi, A., additional, Tanimoto, T., additional, Matsuo, Y., additional, Ino, Y., additional, Kubo, T., additional, Tanaka, A., additional, Akasaka, T., additional, Gonzalez Vilchez, FJ., additional, Piedra Leon, M., additional, Marigomez Estrada, M., additional, Pesquera Gonzalez, C., additional, Ruano Calvo, J., additional, Zarauza Navarro, J., additional, Martin Duran, R., additional, Amado Senaris, JA., additional, Baran, J., additional, Kulakowski, P., additional, Zaborska, B., additional, Schutt, R., additional, Maragiannis, D., additional, Abudiab, M., additional, Sunkara, A., additional, Alvarez, P., additional, Nagueh, S., additional, Zoghbi, WA., additional, Pedrizzetti, GP., additional, Tosi, BT., additional, Pedri, SP., additional, Galanti, GG., additional, Eren, H., additional, Avci, A., additional, Demir, S., additional, Evlice, M., additional, Guner, A., additional, Tabakci, M., additional, Toprak, C., additional, Inanir, M., additional, Kargin, R., additional, Tuohinen, S., additional, Skytta, T., additional, Huhtala, H., additional, Virtanen, V., additional, Kellokumpu-Lehtinen, P-L, additional, Raatikainen, P., additional, Nikus, K., additional, Liu, Y., additional, Tsai, W-C, additional, Mahabir, S., additional, King, G., additional, Cuddy, S., additional, Feigherty, C., additional, Maree, AO., additional, Conlon, N., additional, Murphy, RT., additional, Vizzardi, E., additional, Bonadei, I., additional, Platto, F., additional, Metra, M., additional, Foldeak, D., additional, Domsik, P., additional, Kalapos, A., additional, Borbenyi, Z., additional, Sepp, R., additional, Forster, T., additional, El Tahan, SALAH, additional, Loutfi, M., additional, and El Sharkawy, EMAN, additional

Published
2016
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31. P544The importance of contractile reserve when assessing asymptomatic patients with aortic stenosisP545Determinants of secondary mitral regurgitation in patients with aortic stenosis and preserved ejection fractionP546Exercise physiology in patients with mitral annular calcificationP547Evaluation of left atrial strain in patients with rheumatic mitral stenosisP548Impact of mitral regurgitation on impaired alveolar-capillary membrane diffusion in heart failure with reduced ejection fractionP549Edge-to-edge-repair in patients with dilated cardiomyopathy and secondary mitral regurgitation: acute effect on annular geometryP550Changes in the management of functional mitral regurgitation in the last 8 years in a tertiary referral hospitalP551Percutaneous closure of periprosthetic paravalvular leaks under echocardiographic guidance: establishing an alternative to reoperation?P552Clinical profile and predictors of mortality in infective endocarditis with neurologic complicationsP553TAVI, arterial stiffness and ventricular-arterial couplingP554Low contrast media CT angiography prior to transcatheter aortic valve implantation procedureP555Hemodynamic and prognostic impact of permanent pacemaker implantation following transcatheter aortic valve implantationP556Impact of transfemoral aortic valve implantation or surgical aortic valve replacement on right ventricular function in the early postprocedural phaseP557Effects of atrial fibrillation in patients undergoing mitral valve repair with the mitraclip system:one-year outcomes from the GRASP registryP558Who will not benefit from cardioversionP559Is there residual mechanical dysynchrony after initial IEGM optimization in cardiac resynchronization patients?P560Left ventricular reverse remodeling in dilated cardiomyopathy- maintained subclinical myocardial systolic and diastolic dysfunctionP561Improvement of left ventricular ejection fraction is correlated with serum markers of extracellular matrix fibrosis in dilated cardiomyopathyP5622D-radial strain as a novel tool to identify pre-clinical hypertrophic cardiomyopathy mutation carriersP563Long term vigorous exercise is well tolerated in hypertrophic cardiomyopathyP564Left atrial volume and not diameter is the main determinant of atrial fibrillation in patients with hypertrophic cardiomyopathyP565Assessment of papillary muscle mass, apical displacement and mitral valve function in children and young adults with hypertrophic cardiomyopathy using three dimensional echocardiographyP566Combining tissue Doppler-derived Tei index and two-dimensional speckle tracking imaging derived longitudinal strain to predict outcome of patients with light-chain cardiac amyloidosisP567Left and right ventricular dysfunction in patients submitted to chemotherapy with anthracyclines - predictive value of myocardial deformation imagingP568Echocardiography outcome monitoring of hypertensive patients with diastolic dysfunction under doxorubicin therapy

Author

Van Zalen, JJ., primary, Bantu-Bimbi, JM., primary, Pressman, G., primary, Castro, FA., primary, Fina, D., primary, Faber, L., primary, Ruiz Ortiz, M., primary, Azevedo, AI., primary, Braga, M., primary, Sciatti, E., primary, Annoni, A., primary, Drakopoulou, M., primary, Mas-Stachurska, A., primary, Caggegi, AM., primary, Leitman, M., primary, Ljubas Macek, J., primary, Amorim, S M R, primary, Wisniowska-Smialek, S., primary, Santambrogio, G., primary, Dejgaard, LA., primary, Rosca, M., primary, Joseph, N., primary, Liu, D., primary, Gomes, AC., primary, Pop-Moldovan, AL., primary, Badiani, S., additional, Hart, L., additional, Marshall, A., additional, Patel, N., additional, Lloyd, G., additional, Jahjah, L., additional, Schulze, D., additional, Tran, T., additional, Pepersack, T., additional, Vandenbossche, JL., additional, Unger, P., additional, Topilsky, Y., additional, Donal, E., additional, Azevedo, O., additional, Lourenco, M., additional, Fernandes, M., additional, Oliveira, I., additional, Lourenco, A., additional, Santos, G., additional, Labate, V., additional, Gasperetti, A., additional, Laforgia, PL., additional, Bandera, F., additional, Alfonzetti, E., additional, Guazzi, M., additional, Scholtz, W., additional, Graw, A., additional, Bogunovic, N., additional, Dimitriadis, Z., additional, Scholtz, S., additional, Boergermann, J., additional, Gummert, J., additional, Horstkotte, D., additional, Mesa, D., additional, Delgado, M., additional, Gutierrez Ballesteros, G., additional, Aristizabal Duque, C., additional, Fernandez Cabeza, J., additional, Duran, E., additional, Ferreiro, C., additional, Sanchez Fernandez, J., additional, Suarez De Lezo, J., additional, Braga, P., additional, Rodrigues, A., additional, Santos, L., additional, Melica, B., additional, Ribeiro, J., additional, Sampaio, F., additional, Fontes-Carvalho, R., additional, Dias, A., additional, Gama Ribeiro, V., additional, Nascimento, H., additional, Flores, L., additional, Ribeiro, V., additional, Melao, F., additional, Sousa, C., additional, Macedo, F., additional, Dias, P., additional, Maciel, MJ., additional, Vizzardi, E., additional, Bonadei, I., additional, Platto, F., additional, Metra, M., additional, Formenti, A., additional, Mancini, ME., additional, Pontone, G., additional, Andreini, D., additional, Fusini, L., additional, Muratori, M., additional, Mushtaq, S., additional, Guglielmo, M., additional, Pepi, M., additional, Toutouzas, K., additional, Stathogiannis, K., additional, Michelongona, A., additional, Latsios, G., additional, Synetos, A., additional, Trantalis, G., additional, Sideris, S., additional, Lazaros, G., additional, Tousoulis, D., additional, Cladellas, M., additional, Ble, M., additional, Vaquerizo, B., additional, Farre, N., additional, Molina, L., additional, Gomez, M., additional, Millan, R., additional, Marti, J., additional, Scandura, S., additional, Capranzano, P., additional, Mangiafico, S., additional, Ronsivalle, G., additional, Chiaranda', M., additional, Giaquinta, S., additional, Popolo Rubbio, A., additional, Farruggio, S., additional, Buccheri, S., additional, Imme', S., additional, Castania, G., additional, Di Salvo, ME., additional, Capodanno, D., additional, Tamburino, C., additional, Tyomkin, V., additional, Peleg, E., additional, Fuchs, T., additional, Gabara, Z., additional, Vered, Z., additional, Reskovic Luksic, V., additional, Pasalic, M., additional, Pezo Nikolic, B., additional, Brestovac, M., additional, Separovic Hanzevacki, J., additional, Rodrigues, J., additional, Campelo, M., additional, Moura, B., additional, Martins, E., additional, Silva-Cardoso, J., additional, Rubis, P., additional, Khachatryan, L., additional, Karabinowska, A., additional, Faltyn, P., additional, Dziewiecka, E., additional, Biernacka-Fijalkowska, B., additional, Lesniak-Sobelga, A., additional, Kostkiewicz, M., additional, Podolec, P., additional, Peritore, A., additional, Vallerio, P., additional, Spano', F., additional, Occhi, L., additional, Facchetti, R., additional, Manfredini, E., additional, Turazza, F., additional, Moreo, A., additional, Giannattasio, C., additional, Haland, TF., additional, Lie, OH., additional, Ribe, M., additional, Leren, IS., additional, Edvardsen, T., additional, Haugaa, KH., additional, Mandes, L., additional, Calin, A., additional, Beladan, CC., additional, Enache, R., additional, Mateescu, A., additional, Baicus, C., additional, Ginghina, C., additional, Popescu, BA., additional, Li, L., additional, Craft, M., additional, Mill, L., additional, Erickson, C., additional, Kutty, S., additional, Hu, K., additional, Herrmann, S., additional, Cikes, M., additional, Ertl, G., additional, Weidemann, F., additional, Stoerk, S., additional, Nordbeck, P., additional, Lopes, LR., additional, Correia, M., additional, Ferreira, AG., additional, Mansinho, H., additional, Pereira, H., additional, Trofenciuc, M., additional, Darabantiu, DA., additional, Puschita, M., additional, and Christodorescu, RM., additional

Published
2016
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32. Prognostic value of serial measurements of blood urea nitrogen in ambulatory patients with chronic heart failure

Author

Lombardi, C., Valentina Carubelli, Rovetta, R., Castrini, A. I., Vizzardi, E., Bonadei, I., Sciatti, E., Manerba, A., Benlodi, E., Nodari, S., and Metra, M.

Subjects
Aged, 80 and over, Heart Failure, Male, Chi-Square Distribution, Time Factors, Stroke Volume, Kaplan-Meier Estimate, Middle Aged, Prognosis, Ventricular Function, Left, Blood Urea Nitrogen, Up-Regulation, Hospitalization, Predictive Value of Tests, Risk Factors, Cause of Death, Chronic Disease, Multivariate Analysis, Disease Progression, Humans, Female, Biomarkers, Aged, Retrospective Studies
Abstract

Elevated blood urea nitrogen (BUN) in chronic heart failure (CHF) patients may represent increased neurohormonal activation. The purpose of this work was to evaluate the prognostic value of BUN and its variation in ambulatory patients with stable CHF.In a retrospective analysis we included 241 outpatients with stable CHF (NYHA class I-III). We evaluated patients at baseline and at 6 months, then they have been followed for one year. The population was divided in four groups according to the median value of BUN at baseline and BUN change (percentage) at 6 months (group 1 BUN25.2 mg/dL and variation3.4%, group 2 BUN25.2 mg/dL and ≥3.4 %, group 3 BUN ≥25.2 mg/dL and3.4%, group 4 BUN ≥25.2 mg/dL and ≥3.4%). During a median follow-up of one year, 3 (1.3%) patients died and 49 (20.3%) were hospitalized due to worsening heart failure HF.The Kaplan-Meier curve showed that group 3 and group 4 had worse prognosis compared with group 1 and 2 and that a greater change in BUN, was associated with a further worsening of the prognosis (group 4). Multivariable models confirmed that cardiovascular mortality and HF hospitalizations were more frequent in patients who had an increase of BUN (HR 1.011 [IC 95% 1.002-1.021]; P=0.015).In ambulatory patients with stable chronic heart failure the increment of BUN is associated with increased cardiovascular mortality and heart failure hospitalizations at one-year.

Published
2015

34. Effects of transcatheter aortic valve implantation on left ventricular mass and global longitudinal strain: tissue Doppler and strain evaluation

Author

Vizzardi, E, Sciatti, E, Bonadei, I, Rovetta, R, D'Aloia, A, Gelsomino, S, Lorusso, R, Ettori, F, and Metra, M

Subjects
transcatheter valve implantation, echocardiography, Research-Article, aortic valve
Abstract

Introduction Transcatheter aortic valve implantation is the option of choice for high surgical risk patients suffering from symptomatic aortic stenosis. We aimed to evaluate the influence of baseline global longitudinal strain on left ventricular mass regression after the procedure. Methods We enrolled 23 patients with pure symptomatic severe aortic stenosis who underwent CoreValve prosthesis (Medtronic, Minneapolis, MN) implantation. Everyone had echocardiography registration before the procedure and after six months in order to analyze two-, three-, and four-chamber peak longitudinal strain and global longitudinal strain. Results After the procedure New York Heart Association class, peak and mean aortic valve gradients (p

Published
2014

37. C4. Maternal cardiac changes during uncomplicated twin pregnancy: does the chorionicity matter?

Author

Ghi, T., primary, Franchi, L., additional, Fieni, S., additional, Dall’Asta, A., additional, Gaibazzi, N., additional, Siniscalchi, C., additional, Pedrazzi, G., additional, Sciatti, E., additional, Bonadei, I., additional, Vizzardi, E., additional, Montaguti, E., additional, Degli Esposti, D., additional, Borghi, C., additional, Orabona, R., additional, Prefumo, F., additional, and Frusca, T., additional

Published
2016
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41. Pre-eclampsia and heart failure: a close relationship.

Author

Orabona, R., Prefumo, F., Valcamonico, A., Sciatti, E., Vizzardi, E., Bonadei, I., Metra, M., and Frusca, T.

Abstract

Heart failure (HF) is a clinical syndrome characterized by signs (e.g., pulmonary crackles, peripheral edema, jugular turgor) and symptoms (e.g., breathlessness, fatigue, ankle swelling) caused by structural and/or functional cardiac abnormalities and leading to elevated intracardiac pressure and/or low cardiac output (CO) at rest or during stress. [ABSTRACT FROM AUTHOR]

Published
2018
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45. Effects of transcatheter aortic valve implantation on left ventricular mass and global longitudinal strain: tissue Doppler and strain evaluation.

Author

Vizzardi, E., Sciatti, E., Bonadei, I., Rovetta, R., D’Aloia, A., Gelsomino, S., Lorusso, R., Ettori, F., and Metra, M.

Subjects
CARDIAC surgery, AORTIC valve diseases, CHI-squared test, DOPPLER echocardiography, FISHER exact test, PROSTHETIC heart valves, STATISTICS, T-test (Statistics), TIME, DATA analysis, DATA analysis software
Published
2014

46. Elastic aortic properties in hypertrophic cardiomyopathy: a single center echocardiographic evaluation.

Author

VIZZARDI, E., SCIATTI, E., BONADEI, I., GELSOMINO, S., LORUSSO, R., and METRA, M.

Abstract

OBJECTIVE: Previous studies revealed that hypertrophic cardiomyopathy (HCM) patients have impaired aortic elastic properties with contrasting data about aortic dimensions. We aimed to extend our knowledge about this topic, considering tissue Doppler imaging (TDI) and tissue strain. PATIENTS AND METHODS: 25 HCM patients and 25 healthy volunteers matched for age and sex were enrolled. They underwent transthoracic echocardiography to measure aortic dimensions at four levels (Valsalva sinuses, sinotubular junction, tubular tract, aortic arch), elastic properties (i.e., distensibility, stiffness, M-mode strain, tissue strain), and TDI aortic wall velocities (S', E', A' waves). RESULTS: Aortic dimensions differed between the two groups only at sinotubular junction (18 ± 6 vs. 15 ± 3 mm/m²; p = 0.039) and aortic arch levels (19 ± 5 vs. 11 ± 8 mm/m²; p < 0.001). Aortic stiffness was significantly higher among patients (16.4 ± 23.2 vs. 5.9 ± 3.4; p = 0.034), and TDI waves greater (S': 5.2 ± 1.9 vs. 8.0 ± 2.7 cm/s, p < 0.001; E': -5.3 ± 2.4 vs. -7.2 ± 2.7 cm/s, p = 0.012; A': -5.3 ± 1.6 vs. -8.6 ± 4.5 cm/s, p = 0.002). M-mode and tissue strains, and aortic distensibility did not reach statistical significance, although showing a tendency to altered values in the HCM group. CONCLUSIONS: Patients affected by HCM show a larger aorta and altered aortic elastic properties compared with healthy volunteers. These findings could help to investigate treatment response and prognosis of these alterations. [ABSTRACT FROM AUTHOR]

Published
2014

50. A case of isolated left ventricle diverticulum.

Author

D’Aloia, A., Rovetta, R., Vizzardi, E., Bonadei, I., Sciatti, E., and Metra, M.

Subjects
DIVERTICULUM, COMPUTED tomography, DIFFERENTIAL diagnosis, ECHOCARDIOGRAPHY, LEFT heart ventricle, DIAGNOSIS
Published
2014

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