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227 results on '"Bonacina, F."'

20. PCSK9 modulates cardiac metabolism and impacts HFpEF

Author

Da Dalt, L., primary, Castiglioni, L., additional, Baragetti, A., additional, Audano, M., additional, Svecla, M., additional, Bonacina, F., additional, Pedretti, S., additional, Uboldi, P., additional, Benzoni, P., additional, Giannetti, F., additional, Barbuti, A., additional, Pellegatta, F., additional, Indino, S.L., additional, Donetti, E., additional, Sironi, L., additional, Mitro, N., additional, Catapano, A.L., additional, and Norata, G.D., additional

Published
2022
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27. Unsupervised Feature Selection of Multi-Sensor SCADA Data in Horizontal Axis Wind Turbine Condition Monitoring

Author

Miele, E. S., Corsini, A., Bonacina, F., Peruch, A., Cannarozzo, M., Baldan, D., and Pennisi, F.

Subjects
feature importance, feature selection, scada, hwat condition monitoring, unsupervised method, scada, feature selection, feature importance
Abstract

Wind power is one of the fastest-growing renewable energy sectors and is considered instrumental in the ongoing decarbonization process. However, wind turbines (WTs) present high operation and maintenance costs caused by inefficiencies and failures, leading to ever-increasing attention to effective Condition Monitoring (CM) strategies. Nowadays, modern WTs are integrated with sensor networks as part of the Supervisory Control and Data Acquisition (SCADA) system for supervision purposes. CM of wind farms through predictive models based on routinely collected SCADA data is envisaged as a viable mean of improving producibility by spotting operational inefficiencies. However, given the large number of variables monitored by SCADA systems, selecting those that contribute the most to the modelling of wind turbine health conditions is an open challenge. In this paper, we propose an unsupervised feature selection algorithm based on a novel multivariate Predictive Power Score (PPS). Unlike other approaches in literature that only consider relationships between pairs of variables, here we propose a Combined PPS (CPPS), where the information content of combinations of variables is considered for the prediction of one or more key parameters. The algorithm has been tested on 9 turbines belonging to the same wind farm located in the Italian territory. The results show that the proposed approach is more flexible and outperforms standard PPS.

Published
2022

28. Monocarboxylate transporter 1 deficiency impacts CD8 T lymphocytes proliferation and recruitment to adipose tissue during obesity

Author

Macchi, C, Moregola, A, Greco, MF, Svecla, M, Bonacina, F, Dhup, Suveera, Dadhich, Rakesh K, Audano, M, Sonveaux, Pierre, Mauro, C, Mitro, N, Ruscica, M, Norata, GD, and UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique

Subjects
Proteomics, Biological sciences, Immunology, Metabolomics
Abstract

Lactate sits at the crossroad of metabolism, immunity, and inflammation. The expression of cellular lactate transporter MCT1 (known as Slc16a1) increases during immune cell activation to cope with the metabolic reprogramming. We investigated the impact of MCT1 deficiency on CD8 T cell function during obesity-related inflammatory conditions. The absence of MCT1 impaired CD8 T cell proliferation with a shift of ATP production to mitochondrial oxidative phosphorylation. In mice fed a high-fat diet, a reduction in the number of CD8 T cells, which infiltrated epididymal visceral adipose tissue (epiWAT) or subcutaneous adipose tissue, was observed. Adipose tissue weight and adipocyte area were significantly reduced together with downregulation of adipogenic genes only in the epiWAT. Our findings highlight a distinct effect of MCT1 deficiency in CD8 T cells in the crosstalk with adipocytes and reinforce the concept that targeting immunometabolic reprogramming in lymphocyte could impact the immune-adipose tissue axis in obesity.

Published
2022

43. Fenretinide treatment in APOE-KO mice severely alters erythrocyte turnover and causes a dramatic increase of circulating leukocytes resulting in a worsened atherosclerosis development

Author

Busnelli, M., primary, Manzini, S., additional, Bonacina, F., additional, Colombo, A., additional, Soldati, S., additional, Barbieri, S.S., additional, Amadio, P., additional, Sandrini, L., additional, Arnaboldi, F., additional, Donetti, E., additional, Laaksonen, R., additional, Paltrinieri, S., additional, Scanziani, E., additional, and Chiesa, G., additional

Published
2020
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49. Post-Prandial Lipemia And Cd36

Author

Zampoleri, V., primary, Baragetti, A., additional, Bonacina, F., additional, Pedretti, S., additional, Grigore, L., additional, Pellegatta, F., additional, Redaelli, L., additional, Mitro, N., additional, Norata, D.G., additional, and Catapano, A.L., additional

Published
2019
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