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4. Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

Author

Chen, Qian, Perales, Celia, Soria, María Eugenia, García-Cehic, Damir, Gregori, Josep, Rodríguez-Frías, Francisco, Buti, María, Crespo, Javier, Calleja, José Luis, Tabernero, David, Vila, Marta, Lázaro, Fernando, Rando-Segura, Ariadna, Nieto-Aponte, Leonardo, Llorens-Revull, Meritxell, Cortese, Maria Francesca, Fernandez-Alonso, Irati, Castellote, José, Niubó, Jordi, Imaz, Arkaitz, Xiol, Xavier, Castells, Lluís, Riveiro-Barciela, Mar, Llaneras, Jordi, Navarro, Jordi, Vargas-Blasco, Víctor, Augustin, Salvador, Conde, Isabel, Rubín, Ángel, Prieto, Martín, Torras, Xavier, Margall, Nuria, Forns, Xavier, Mariño, Zoe, Lens, Sabela, Bonacci, Martin, Pérez-del-Pulgar, Sofía, Londoño, Maria Carlota, García-Buey, María Luisa, Sanz-Cameno, Paloma, Morillas, Rosa, Martró, Elisa, Saludes, Verónica, Masnou-Ridaura, Helena, Salmerón, Javier, Quíles, Rosa, Carrión, José Antonio, Forné, Montserrat, Rosinach, Mercè, Fernández, Inmaculada, García-Samaniego, Javier, Madejón, Antonio, Castillo-Grau, Pilar, López-Núñez, Carme, Ferri, María José, Durández, Rosa, Sáez-Royuela, Federico, Diago, Moisés, Gimeno, Concepción, Medina, Rafael, Buenestado, Juan, Bernet, Albert, Turnes, Juan, Trigo-Daporta, Matilde, Hernández-Guerra, Manuel, Delgado-Blanco, Manuel, Cañizares, Angelina, Arenas, Juan Ignacio, Gomez-Alonso, Maria Juana, Rodríguez, Manuel, Deig, Elisabet, Olivé, Gemma, Río, Oscar del, Cabezas, Joaquín, Quiñones, Ildefonso, Roget, Mercè, Montoliu, Silvia, García-Costa, Juan, Force, Lluís, Blanch, Silvia, Miralbés, Miguel, López-de-Goicoechea, María José, García-Flores, Angels, Saumoy, María, Casanovas, Teresa, Baliellas, Carme, Gilabert, Pau, Martin-Cardona, Albert, Roca, Rosa, Barenys, Mercè, Villaverde, Joana, Salord, Silvia, Camps, Blau, Silvan di Yacovo, María, Ocaña, Imma, Sauleda, Silvia, Bes, Marta, Carbonell, Judit, Vargas-Accarino, Elena, Ruzo, Sofía P., Guerrero-Murillo, Mercedes, Von Massow, Georg, Costafreda, María Isabel, López, Rosa Maria, González-Moreno, Leticia, Real, Yolanda, Acero-Fernández, Doroteo, Viroles, Silvia, Pamplona, Xavier, Cairó, Mireia, Ocete, María Dolores, Macías-Sánchez, José Francisco, Estébanez, Angel, Quer, Joan Carles, Mena-de-Cea, Álvaro, Otero, Alejandra, Castro-Iglesias, Ángeles, Suárez, Francisco, Vázquez, Ángeles, Vieito, David, López-Calvo, Soledad, Vázquez-Rodríguez, Pilar, Martínez-Cerezo, Francisco José, Rodríguez, Raúl, Macenlle, Ramiro, Cachero, Alba, Mereish, Gasshan, Mora-Moruny, Carme, Fábregas, Silvia, Sacristán, Begoña, Albillos, Agustín, Sánchez-Ruano, Juan José, Baluja-Pino, Raquel, Fernández-Fernández, Javier, González-Portela, Carlos, García-Martin, Carmen, Sánchez-Antolín, Gloria, Andrade, Raúl Jesús, Simón, Miguel Angel, Pascasio, Juan Manuel, Romero-Gómez, Manolo, Antonio del-Campo, José, Domingo, Esteban, Esteban, Rafael, Esteban, Juan Ignacio, and Quer, Josep

Published
2020
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7. Impact of comorbidities on patient outcomes after interferon-free therapy-induced viral eradication in hepatitis C

Author

Ampuero, Javier, Jimeno, Carlota, Quiles, Rosa, Rosales, José Miguel, Llerena, Susana, Palomo, Nieves, Cordero, Patricia, Serrano, Francisco Javier, Urquijo, Juan José, Moreno-Planas, José María, Ontanilla, Guillermo, Hernández, Marta, Ortega-Alonso, Aída, Maraver, Marta, Bonacci, Martín, Rojas, Ángela, Figueruela, Blanca, Forns, Xavier, Andrade, Raúl J., Calleja, José Luis, Diago, Moisés, Carmona, Isabel, de la Mata, Manuel, Buti, María, Crespo, Javier, Pascasio, Juan Manuel, Navarro, José María, Salmerón, Javier, and Romero-Gómez, Manuel

Published
2018
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10. Genetic diversity and pathogenicity on root seedlings from three soybean cultivars of Fusarium graminearum isolated from maize crop residues

Author

Bonacci, Martín and Barros, Germán

Subjects
Rastrojos de maíz, crop residues, Crop residues, Soja, Fungicide, Food processing and manufacture, Compatibilidad micelial, lcsh:Agriculture, Población vegetal, Mycelial compatibility, Fungicidas, Plántulas, fungicide, Rastrojo, Pathogenicity, pathogenicity, soybean, Fungicida curasemilla, lcsh:TP368-456, Patogenicidad, fungi, Gibberella zeae, lcsh:S, food and beverages, Agriculture, Métodos estadísticos, TP368-456, Diversidad genética, lcsh:Food processing and manufacture, Fusarium graminearum, mycelial compatibility, Soybean
Abstract

Crops residues are an important source of maintenance of Fusarium graminearum inoculum in the soybean agroecosystem. Given that these populations can interact in the substrate through mechanisms of mycelial recognition and that they can come into direct contact with the implanted seed and cause disease, the following objectives were set: (1) to evaluate the genetic diversity through of the mycelial compatibility of F. graminearum strains isolated from maize crop residues; (2) to analyze the pathogenicity of F. graminearum strains isolated from crop residues towards soybean seedlings from different cultivars treated and untreated with fungicide. Mycelial compatibility studies showed a unique pattern of mycelial compatibility for each strain, indicating a great heterogeneity in the population evaluated. Pathogenicity tests in all strains tested were capable of causing symptoms of root rot with varying degrees of severity and reductions in the height of seedlings. In the factorial statistical analysis, the greatest effect was marked by the soybean cultivar effect. A clear decline in the severity index was also observed with the fungicide application, so this would be a useful prevention tool to reduce the intensity in soybean seedling diseases. Los rastrojos de cultivos antecesores son una fuente importante de mantenimiento del inóculo de Fusarium graminearum en el agroecosistema de la soja. Teniendo en cuenta que estas poblaciones pueden interactuar en el sustrato a través de mecanismos de reconocimiento micelial y que las mismas pueden entrar en contacto directo con la semilla implantada y causar enfermedad, se plantearon los siguientes objetivos: (1) Evaluar la diversidad genética a través de la compatibilidad micelial en cepas de F. graminearum aisladas de rastrojos de maíz; (2) Analizar la patogenicidad de cepas de F. graminearum aisladas de rastrojos respecto de la podredumbre de raíz en plántulas de distintos cultivares de soja tratadas y no tratadas con fungicida curasemillas. Los estudios de compatibilidad micelial mostraron un único patrón de compatibilidad micelial para cada cepa, indicando una gran heterogeneidad en la población evaluada. En los ensayos de patogenicidad todas las cepas evaluadas fueron capaces de provocar síntomas de podredumbre de la raíz con distintos grados de severidad y reducciones en la altura de plántulas. El análisis estadístico factorial demostró que el mayor efecto observado en las variables independientes estuvo marcado por el efecto del cultivar de soja evaluado. También se observó una clara disminución en el índice de severidad con la aplicación de un fungicida curasemilla, por lo que esta sería una herramienta útil de prevención para disminuir la intensidad en las enfermedades de plántulas de soja. Fil: Bonacci, Martín. Universidad Nacional de Río Cuarto Fil: Barros, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas

Published
2019

12. THU-046-Implementation of acute kidney injury criteria to patients with acute-on-chronic liver failure: Characteristics of effect on outcomes

Author

Napoleone, Laura, primary, Solé, Cristina, additional, Pose, Elisa, additional, Carol, Marta, additional, Juanola, Adrià, additional, Huelín, Patrícia, additional, De Prada, Glòria, additional, Cervera, Marta, additional, Bonacci, Martín, additional, Fabrellas, Núria, additional, Graupera, Isabel, additional, Solà, Elsa, additional, and Ginès, Pere, additional

Published
2019
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13. Erratum : Neutrophil and monocyte function in patients with chronic hepatitis C undergoing antiviral therapy with regimens containing protease inhibitors with and without interferon (PLoS ONE (2016) 11:11 (e0166631) DOI: 10.1371/journal.pone.0166631)

Author

Gambato, Martina, Caro-Pérez, Noelia, González, Patricia, Cañete Hidalgo, Nuria, Mariño, Zoe, Lens, Sabela, Bonacci, Martín, Bartres, Concepció, Sánchez-Tapias, José María, Carrión Rodríguez, José Antonio, Forns, Xavier, Juan, Manuel, Pérez-Del-Pulgar, Sofía, Londoño, María Carlota, and Universitat Autònoma de Barcelona

Abstract

There are errors in the Funding section. The correct funding information is as follows: SPP has received a grant from Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (PI13/00155), co-funded by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, Una manera de hacer Europa. XF has received a grant from L' Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) (2014-SGR-605). XF was also supported in part by grant PI15/00151, integrated in Plan Nacional de I+D+I and funded by ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER-"Una manera de Hacer Europa"). MG was funded with an EASL Entry Level Research Fellowship (Dame Sheila Sherlock EASL Fellowship Programme).

Published
2017

14. FRI080 - Obesity-specific health-related quality of life in patients with non-alcoholic steatohepatitis: results from the regenerate study

Author

Younossi, Zobair M., Stepanova, Maria, Nader, Fatema, Loomba, Rohit, Anstee, Quentin, Ratziu, Vlad, Harrison, Stephen, Sanyal, Arun, George, Jacob, Beckebaum, Susanne, Orr, David, Mazzella, Giuseppe, Vargas Blasco, Vićtor Manuel, Gluud, Lise Lotte, Safadi, Rifaat, Trotter, James F., Behari, Jaideep, Sheridan, David, Sheikh, Muhammad, Bonacci, Martin, Cawkwell, Gail, Wong, Bruce, Bedossa, Pierre, Goodman, Zachary, and Rinella, Mary

Published
2020
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15. Mo1448 OBETICHOLIC ACID IMPROVES TRANSAMINASES IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS: RESULTS FROM THE 18-MONTH INTERIM ANALYSIS OF THE REGENERATE STUDY

Author

Rinella, Mary E., Allison, Michael, Mathurin, Philippe, Lawitz, Eric, Anstee, Quentin M., Schiefke, Ingolf, Petta, Salvatore, Anty, Rodolphe, Marotta, Paul, Calleja, Jose L., Hussaini, Syed, Kowdley, Kris V., Abdelmalek, Manal F., Zaru, Luna, Shringarpure, Reshma, Wang, Lixia, MacConell, Leigh, Wong, Bruce, Trylesinki, Aldo, Bonacci, Martin, Ratziu, Vlad, Sanyal, Arun J., and Dufour, Jean-Francois

Published
2020
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16. 326 OBESITY-SPECIFIC HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS: RESULTS FROM THE REGENERATE STUDY

Author

Younossi, Zobair M., Stepanova, Maria, Nader, Fatema, Loomba, Rohit, Anstee, Quentin M., Ratziu, Vlad, Harrison, Stephen, Sanyal, Arun J., George, Jacob, Beckebaum, Susanne, Orr, David, Mazzella, Giuseppe, Vargas, Victor, Gluud, Lise L., Safadi, Rifaat, Trotter, James, Behari, Jaideep, Sheridan, David, Sheikh, Muhammad Y., Bonacci, Martin, Cawkwell, Gail, Wong, Bruce, Bedossa, Pierre, Goodman, Zachary, and Rinella, Mary E.

Published
2020
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19. Neutrophil and monocyte function in patients with chronic hepatitis c undergoing antiviral therapy with regimens containing protease inhibitors with and without interferon

Author

Gambato, Martina, Caro-Pérez, Noelia, González, Patricia, Cañete Hidalgo, Nuria, Mariño, Zoe, Lens, Sabela, Bonacci, Martín, Bartres, Concepció, Sánchez-Tapias, José María, Carrión, José A., Forns, Xavier, Juan, Manuel, Pérez-Del-Pulgar, Sofía, Londoño, María Carlota, Universitat Autònoma de Barcelona, and Universitat de Barcelona

Subjects
Simeprevir, Neutrophils, Physiology, lcsh:Medicine, Interferó, Biochemistry, Monocytes, Telaprevir, chemistry.chemical_compound, White Blood Cells, 0302 clinical medicine, Interferon, Animal Cells, Medicine and Health Sciences, Medicine, Malalties cròniques, Public and Occupational Health, 030212 general & internal medicine, lcsh:Science, Immune Response, Respiratory Burst, Multidisciplinary, Liver Diseases, Hepatitis C, Hematology, Vaccination and Immunization, Respiratory burst, Body Fluids, Blood, Cirrhosis, Hepatic cirrhosis, Cell Processes, 030211 gastroenterology & hepatology, Cellular Types, Anatomy, medicine.drug, Research Article, Cirrosi hepàtica, Immune Cells, Immunology, Gastroenterology and Hepatology, 03 medical and health sciences, Antiviral Therapy, Phagocytosis, Boceprevir, Blood Cells, business.industry, Ribavirin, lcsh:R, Biology and Life Sciences, Proteins, Cell Biology, medicine.disease, chemistry, Chronic diseases, lcsh:Q, Cytokine secretion, Preventive Medicine, Interferons, business
Abstract

Real-life data showed an increased incidence of bacterial infections in patients with advanced liver disease receiving a protease inhibitor (PI)-containing antiviral regimen against hepatitis C (HCV). However, the causes of this event are unknown. We hypothesized that PIs might impair innate immune responses through the inhibition of proteases participating in the anti-bacterial functions of neutrophils and monocytes. The aims of the study were to assess phagocytic and oxidative burst capacity in neutrophils and monocytes obtained from patients receiving a PI containing-antiviral regimen, and to determine cytokine secretion after neutrophil stimulation with flagellin. Forty patients with chronic HCV (80% with cirrhosis) were enrolled in the study, 28 received triple therapy (Group A) with pegylated-interferon and ribavirin for 4 weeks followed by the addition of a PI (telaprevir, boceprevir or simeprevir), and 12 patients received an interferon-free regimen (Group B) with simeprevir and sofosbuvir. Phagocytosis and oxidative burst capacity were analyzed by flow cytometry at baseline, week 4, and week 8 of therapy. In neutrophils from Group A patients, oxidative burst rate and oxidative enzymatic activity per cell significantly decreased throughout the study period (p = 0.014 and p = 0.010, respectively). Pairwise comparisons showed a decrease between baseline and week 4 and 8 of therapy. No differences were observed after the introduction of the PI. The oxidative enzymatic activity per cell in monocytes significantly decrease during the study period (p = 0.042) due to a decrease from baseline to week 8 of therapy (p = 0.037) in patients from Group A. None of these findings were observed in Group B patients. Cytokine secretion did not significantly change during the study in both groups. In conclusion, our data suggest that the use interferon (rather than the PI) has a deleterious effect on neutrophil and monocyte phagocytic and oxidative burst capacity in this cohort of patients with HCV-related advanced liver fibrosis.

Published
2016

20. Correction: Neutrophil and Monocyte Function in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy with Regimens Containing Protease Inhibitors with and without Interferon

Author

Gambato, Martina, primary, Caro-Pérez, Noelia, additional, González, Patricia, additional, Cañete, Nuria, additional, Mariño, Zoe, additional, Lens, Sabela, additional, Bonacci, Martín, additional, Bartres, Concepció, additional, Sánchez-Tapias, José-María, additional, Carrión, José A., additional, Forns, Xavier, additional, Juan, Manel, additional, Pérez-del-Pulgar, Sofía, additional, and Londoño, María-Carlota, additional

Published
2017
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21. Neutrophil and Monocyte Function in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy with Regimens Containing Protease Inhibitors with and without Interferon

Author

Gambato, Martina, primary, Caro-Pérez, Noelia, additional, González, Patricia, additional, Cañete, Nuria, additional, Mariño, Zoe, additional, Lens, Sabela, additional, Bonacci, Martín, additional, Bartres, Concepció, additional, Sánchez-Tapias, José-María, additional, Carrión, José A., additional, Forns, Xavier, additional, Juan, Manel, additional, Pérez-del-Pulgar, Sofía, additional, and Londoño, María-Carlota, additional

Published
2016
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