9 results on '"Bonab, Maziar Ashrafian"'
Search Results
2. The effective function of circular RNA in colorectal cancer
- Author
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Ameli-Mojarad, Mandana, Ameli-Mojarad, Melika, Hadizadeh, Mahrooyeh, Young, Chris, Babini, Hosna, Nazemalhosseini-Mojarad, Ehsan, and Bonab, Maziar Ashrafian
- Published
- 2021
- Full Text
- View/download PDF
3. ANRIL as a prognostic biomarker in colon pre-cancerous lesion detection via non-invasive sampling
- Author
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Sadri, Shadi, primary, Rejali, Leili, additional, Hadizadeh, Mahrooyeh, additional, Aghdaei, Hamid Asadzadeh, additional, Young, Chris, additional, Nazemalhosseini-Mojarad, Ehsan, additional, Zali, Mohammad Reza, additional, and Bonab, Maziar Ashrafian, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant: A coastal-inland contrast
- Author
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El-Sibai, Mirvat, Platt, Daniel E., Haber, Marc, Xue, Yali, Youhanna, Sonia C., Wells, Spencer R., Izaabel, Hassan, Sanyoura, May F., Harmanani, Haidar, Bonab, Maziar Ashrafian, Behbehani, Jaafar, Hashwa, Fuad, Tyler-Smith, Chris, and Zalloua, Pierre A.
- Published
- 2009
- Full Text
- View/download PDF
5. ANRIL as a prognostic biomarker in colon pre-cancerous lesion detection via non-invasive sampling.
- Author
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Sadri, Shadi, Rejali, Leili, Hadizadeh, Mahrooyeh, Aghdaei, Hamid Asadzadeh, Young, Chris, Nazemalhosseini-Mojarad, Ehsan, Zali, Mohammad Reza, and Bonab, Maziar Ashrafian
- Subjects
PRECANCEROUS conditions ,ADENOMATOUS polyps ,LINCRNA ,EARLY detection of cancer ,BIOMARKERS ,COLON (Anatomy) - Abstract
Long non-coding RNAs have been proposed as biomarkers for the detection, prevention and screening of various malignancies. In this study, two lncRNAs (ANRIL and BANCR) were assessed for biomarker application in the early detection of colorectal cancer (CRC) through stool specimen testing, as a non-invasive and cost-effective methodology. A total of 40 stool samples were collected from patients referred to the hospital with colorectal cancer or adenomatous polyps as pre-cancerous lesions; patients were diagnosed using colonoscopy and pathology reports were available. Twenty control samples were also obtained from healthy subjects for comparison. RNA extraction and cDNA synthesis were followed by real-time PCR to evaluate lncRNA expression. The up-regulation of ANRIL in 20% of samples taken from polyp patients, combined with up-regulation in 65% of patients with CRC, confirmed the potential usefulness of ANRIL as a prognostic biomarker (AUC 0.95; P < 0.0001). BANCR relative expression analysis illustrated significant up-regulation in polyp (P < 0.04) and tumoural participants (P < 0.03) compared with normal control individuals. The expression patterns of ANRIL and BANCR in polyp cases were significantly correlated according to correlation analysis (r = 0.45, P < 0.045). ANRIL expression patterns in stool specimens of polyp and tumour cases supported the use of ANRIL as a prognostic biomarker for screening patients in the early stages of CRC. Up-regulation of BANCR in pre-cancerous lesions as well as down-regulation of ANRIL may also be a specific marker pair for easy, convenient and fast CRC prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
6. Mapping post-glacial expansions
- Author
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Khazen, Georges, Zalloua, Pierre A., Platt, Daniel E., Dagher- Kharrat, Magda Bou, Douaihy, Bouchra, Bonab, Maziar Ashrafian, Salloum, Angelique, Mouzaya, Francis, Luiselli, Donata, Tyler-Smith, Chris, Renfrew, Colin, Matisoo-Smith, Elizabeth, Khazen, Georges, Zalloua, Pierre A., Platt, Daniel E., Dagher- Kharrat, Magda Bou, Douaihy, Bouchra, Bonab, Maziar Ashrafian, Salloum, Angelique, Mouzaya, Francis, Luiselli, Donata, Tyler-Smith, Chris, Renfrew, Colin, and Matisoo-Smith, Elizabeth
- Abstract
Archaeological, palaeontological and geological evidence shows that post-glacial warming released human populations from their various climate-bound refugia. Yet specific connections between these refugia and the timing and routes of post-glacial migrations that ultimately established modern patterns of genetic variation remain elusive. Here, we use Y-chromosome markers combined with autosomal data to reconstruct population expansions from regional refugia in Southwest Asia. Populations from three regions in particular possess distinctive autosomal genetic signatures indicative of likely refugia: one, in the north, centered around the eastern coast of the Black Sea, the second, with a more Levantine focus, and the third in the southern Arabian Peninsula. Modern populations from these three regions carry the widest diversity and may indeed represent the most likely descendants of the populations responsible for the Neolithic cultures of Southwest Asia. We reveal the distinct and datable expansion routes of populations from these three refugia throughout Southwest Asia and into Europe and North Africa and discuss the possible correlations of these migrations to various cultural and climatic events evident in the archaeological record of the past 15,000 years.
- Published
- 2017
7. Geographical Structure of the Y-chromosomal Genetic Landscape of the Levant
- Author
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El-Sibai, Mirvat, Platt, Daniel E., Haber, Marc, Xue, Yali, Youhanna, Sonia C., Wells, R. Spencer, Izaabel, Hassan, Sanyoura, May F., Harmanani, Haidar, Bonab, Maziar Ashrafian, Behbehani, Jaafar, Hashwa, Fuad, Tyler-Smith, Chris, Zalloua, Pierre A., The Genographic Consortium, El-Sibai, Mirvat, Platt, Daniel E., Haber, Marc, Xue, Yali, Youhanna, Sonia C., Wells, R. Spencer, Izaabel, Hassan, Sanyoura, May F., Harmanani, Haidar, Bonab, Maziar Ashrafian, Behbehani, Jaafar, Hashwa, Fuad, Tyler-Smith, Chris, Zalloua, Pierre A., and The Genographic Consortium
- Abstract
We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries. The diversity within some of these haplogroups was also examined. The Levantine populations showed clustering in SNP and STR analyses when considered against a broad Middle-East and North African background. However, we also found a coastal-inland, east-west pattern of diversity and frequency distribution in several haplogroups within the small region of the Levant. Since estimates of effective population size are similar in the two regions, this strong pattern is likely to have arisen mainly from differential migrations, with different lineages introduced from the east and west.
- Published
- 2015
8. Afghanistan's Ethnic Groups Share a Y-Chromosomal Heritage Structured by Historical Events.
- Author
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Haber, Marc, Platt, Daniel E., Bonab, Maziar Ashrafian, Youhanna, Sonia C., Soria-Hernanz, David F., Begoña Martínez-Cruz, Douaihy, Bouchra, Ghassibe-Sabbagh, Michella, Rafatpanah, Hoshang, Ghanbari, Mohsen, Whale, John, Balanovsky, Oleg, Wells, R. Spencer, Comas, David, Tyler-Smith, Chris, and Zalloua, Pierre A.
- Subjects
ETHNIC groups ,GENETICS ,Y chromosome ,ETHNOLOGY ,EMIGRATION & immigration ,PALEOLIMNOLOGY ,MILITARY invasion - Abstract
Afghanistan has held a strategic position throughout history. It has been inhabited since the Paleolithic and later became a crossroad for expanding civilizations and empires. Afghanistan's location, history, and diverse ethnic groups present a unique opportunity to explore how nations and ethnic groups emerged, and how major cultural evolutions and technological developments in human history have influenced modern population structures. In this study we have analyzed, for the first time, the four major ethnic groups in present-day Afghanistan: Hazara, Pashtun, Tajik, and Uzbek, using 52 binary markers and 19 short tandem repeats on the non-recombinant segment of the Y-chromosome. A total of 204 Afghan samples were investigated along with more than 8,500 samples from surrounding populations important to Afghanistan's history through migrations and conquests, including Iranians, Greeks, Indians, Middle Easterners, East Europeans, and East Asians. Our results suggest that all current Afghans largely share a heritage derived from a common unstructured ancestral population that could have emerged during the Neolithic revolution and the formation of the first farming communities. Our results also indicate that inter-Afghan differentiation started during the Bronze Age, probably driven by the formation of the first civilizations in the region. Later migrations and invasions into the region have been assimilated differentially among the ethnic groups, increasing inter-population genetic differences, and giving the Afghans a unique genetic diversity in Central Asia. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
9. Influences of history, geography, and religion on genetic structure: the Maronites in Lebanon.
- Author
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Haber, Marc, Platt, Daniel E., Badro, Danielle A., Yali Xue, El-Sibai, Mirvat, Bonab, Maziar Ashrafian, Youhanna, Sonia C., Saade, Stephanie, Soria-Hernanz, David F., Royyuru, Ajay, Wells, R. Spencer, Tyler-Smith, Chris, and Zalloua, Pierre A.
- Subjects
Y chromosome ,POPULATION genetics ,EMIGRATION & immigration ,CULTURE diffusion ,MARONITES - Abstract
Cultural expansions, including of religions, frequently leave genetic traces of differentiation and in-migration. These expansions may be driven by complex doctrinal differentiation, together with major population migrations and gene flow. The aim of this study was to explore the genetic signature of the establishment of religious communities in a region where some of the most influential religions originated, using the Y chromosome as an informative male-lineage marker. A total of 3139 samples were analyzed, including 647 Lebanese and Iranian samples newly genotyped for 28 binary markers and 19 short tandem repeats on the non-recombinant segment of the Y chromosome. Genetic organization was identified by geography and religion across Lebanon in the context of surrounding populations important in the expansions of the major sects of Lebanon, including Italy, Turkey, the Balkans, Syria, and Iran by employing principal component analysis, multidimensional scaling, and AMOVA. Timing of population differentiations was estimated using BATWING, in comparison with dates of historical religious events to determine if these differentiations could be caused by religious conversion, or rather, whether religious conversion was facilitated within already differentiated populations. Our analysis shows that the great religions in Lebanon were adopted within already distinguishable communities. Once religious affiliations were established, subsequent genetic signatures of the older differentiations were reinforced. Post-establishment differentiations are most plausibly explained by migrations of peoples seeking refuge to avoid the turmoil of major historical events. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
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