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1. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Author

Heo, Ran, Park, Hyung-Bok, Marques, Hugo, Stuijfzand, Wijnand J., Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Al-Mallah, Mouaz H., Nakazato, Ryo, Schoepf, U. Joseph, Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, de Waard, Guus A., Sprengers, Ralf W., Raijmakers, Pieter G., Nurmohamed, Nick S., Danad, Ibrahim, Jukema, Ruurt A., de Winter, Ruben W., de Groot, Robin J., Driessen, Roel S., Bom, Michiel J., van Diemen, Pepijn, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Katz, Richard J., Stroes, Erik S.G., Wang, Hao, Chan, Chung, Crabtree, Tami, Aquino, Melissa, Min, James K., Earls, James P., Bax, Jeroen J., Choi, Andrew D., Knaapen, Paul, and van Rosendael, Alexander R.

Published
2024
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3. Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity

Author

Jonas, Rebecca, Patel, Toral, Crabtree, Tami R., Jennings, Robert S., Heo, Ran, Park, Hyung-Bok, Marques, Hugo, Chang, Hyuk-Jae, Stuijfzand, Wijnand J., van Rosendael, Alexander R., Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Al-Mallah, Mouaz H., Nakazato, Ryo, Schoepf, U. Joseph, Driessen, Roel S., Bom, Michiel J., Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A., Pontone, Gianluca, Andreini, Daniele, Bax, Jeroen J., Choi, Andrew D., Earls, James P., Hoffmann, Udo, Min, James K., and Villines, Todd C.

Published
2023
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4. Percutaneous coronary intervention of native coronary artery versus saphenous vein graft in patients with prior coronary artery bypass graft surgery: Rationale and design of the multicenter, randomized PROCTOR trial

Author

de Winter, Ruben W., Walsh, Simon J., Hanratty, Colm G., Spratt, James C., Sprengers, Ralf W., Twisk, Jos W.R., Vegting, Iris, Schumacher, Stefan P., Bom, Michiel J., Hoek, Roel, Verouden, Niels J., Delewi, Ronak, Nap, Alexander, and Knaapen, Paul

Published
2023
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7. AI Evaluation of Stenosis on Coronary CTA, Comparison With Quantitative Coronary Angiography and Fractional Flow Reserve: A CREDENCE Trial Substudy

Author

Griffin, William F., Choi, Andrew D., Riess, Joanna S., Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U. Joseph, Driessen, Roel S., Bom, Michiel J., Thompson, Randall, Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A., Pontone, Gianluca, Andreini, Daniele, and Earls, James P.

Published
2023
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8. The effect of scan and patient parameters on the diagnostic performance of AI for detecting coronary stenosis on coronary CT angiography

Author

Jonas, Rebecca A., Barkovich, Emil, Choi, Andrew D., Griffin, William F., Riess, Joanna, Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U. Joseph, Driessen, Roel S., Bom, Michiel J., Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A., Pontone, Gianluca, Andreini, Daniele, Guglielmo, Marco, Al-Mallah, Mouaz H., Jennings, Robert S., Crabtree, Tami R., and Earls, James P.

Published
2022
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10. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Author

Nurmohamed, Nick S., primary, Danad, Ibrahim, additional, Jukema, Ruurt A., additional, de Winter, Ruben W., additional, de Groot, Robin J., additional, Driessen, Roel S., additional, Bom, Michiel J., additional, van Diemen, Pepijn, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Chang, Hyuk-Jae, additional, Katz, Richard J., additional, Stroes, Erik S.G., additional, Wang, Hao, additional, Chan, Chung, additional, Crabtree, Tami, additional, Aquino, Melissa, additional, Min, James K., additional, Earls, James P., additional, Bax, Jeroen J., additional, Choi, Andrew D., additional, Knaapen, Paul, additional, van Rosendael, Alexander R., additional, Heo, Ran, additional, Park, Hyung-Bok, additional, Marques, Hugo, additional, Stuijfzand, Wijnand J., additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Al-Mallah, Mouaz H., additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, de Waard, Guus A., additional, Sprengers, Ralf W., additional, and Raijmakers, Pieter G., additional

Published
2024
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11. Functional recovery after percutaneous revascularization of coronary chronic total occlusions: insights from cardiac magnetic resonance tissue tracking

Author

Everaars, Henk, Schumacher, Stefan P., Stuijfzand, Wijnand J., van Basten Batenburg, Martijn, Huynh, Jennifer, van Diemen, Pepijn A., Bom, Michiel J., de Winter, Ruben W., van de Ven, Peter M., van Loon, Ramon B., van Rossum, Albert C., Opolski, Maksymilian P., Nap, Alexander, and Knaapen, Paul

Published
2021
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15. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD

Author

Cardiologie, Team Medisch, Nurmohamed, Nick S., Bom, Michiel J., Jukema, Ruurt A., de Groot, Robin J., Driessen, Roel S., van Diemen, Pepijn A., de Winter, Ruben W., Gaillard, Emilie L., Sprengers, Ralf W., Stroes, Erik S.G., Min, James K., Earls, James P., Cardoso, Rhanderson, Blankstein, Ron, Danad, Ibrahim, Choi, Andrew D., Knaapen, Paul, Cardiologie, Team Medisch, Nurmohamed, Nick S., Bom, Michiel J., Jukema, Ruurt A., de Groot, Robin J., Driessen, Roel S., van Diemen, Pepijn A., de Winter, Ruben W., Gaillard, Emilie L., Sprengers, Ralf W., Stroes, Erik S.G., Min, James K., Earls, James P., Cardoso, Rhanderson, Blankstein, Ron, Danad, Ibrahim, Choi, Andrew D., and Knaapen, Paul

Published
2024

16. Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation

Author

Team Medisch, Nurmohamed, Nick S., Gaillard, Emilie L., Malkasian, Shant, de Groot, Robin J., Ibrahim, Shirin, Bom, Michiel J., Kaiser, Yannick, Earls, James P., Min, James K., Kroon, Jeffrey, Planken, R. Nils, Danad, Ibrahim, van Rosendael, Alexander R., Choi, Andrew D., Stroes, Erik S.G., Knaapen, Paul, Team Medisch, Nurmohamed, Nick S., Gaillard, Emilie L., Malkasian, Shant, de Groot, Robin J., Ibrahim, Shirin, Bom, Michiel J., Kaiser, Yannick, Earls, James P., Min, James K., Kroon, Jeffrey, Planken, R. Nils, Danad, Ibrahim, van Rosendael, Alexander R., Choi, Andrew D., Stroes, Erik S.G., and Knaapen, Paul

Published
2024

18. Corrigendum to ‘Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity’ The American Journal of Cardiology, Volume 204, 1 October 2023, Pages 276-283

Author

Jonas, Rebecca, primary, Patel, Toral, additional, Crabtree, Tami R., additional, Jennings, Robert S., additional, Heo, Ran, additional, Park, Hyung-Bok, additional, Marques, Hugo, additional, Chang, Hyuk-Jae, additional, Stuijfzand, Wijnand J., additional, Rosendael, Alexander R. van, additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Al-Mallah, Mouaz H., additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, Knaapen, Paul, additional, de Waard, Guus A., additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Bax, Jeroen J., additional, Choi, Andrew D., additional, Earls, James P., additional, Hoffmann, Udo, additional, Min, James K., additional, and Villines, Todd C., additional

Published
2023
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19. The diagnostic performance of quantitative flow ratio and perfusion imaging in patients with prior coronary artery disease

Author

van Diemen, Pepijn A, primary, de Winter, Ruben W, additional, Schumacher, Stefan P, additional, Everaars, Henk, additional, Bom, Michiel J, additional, Jukema, Ruurt A, additional, Somsen, Yvemarie B, additional, Raijmakers, Pieter G, additional, Kooistra, Rolf A, additional, Timmer, Janny, additional, Maaniitty, Teemu, additional, Robbers, Lourens F, additional, von Bartheld, Martin B, additional, Demirkiran, Ahmet, additional, van Rossum, Albert C, additional, Reiber, Johan H, additional, Knuuti, Juhani, additional, Underwood, S Richard, additional, Nagel, Eike, additional, Knaapen, Paul, additional, Driessen, Roel S, additional, and Danad, Ibrahim, additional

Published
2023
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20. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD

Author

Nurmohamed, Nick S., primary, Bom, Michiel J., additional, Jukema, Ruurt A., additional, de Groot, Robin J., additional, Driessen, Roel S., additional, van Diemen, Pepijn A., additional, de Winter, Ruben W., additional, Gaillard, Emilie L., additional, Sprengers, Ralf W., additional, Stroes, Erik S.G., additional, Min, James K., additional, Earls, James P., additional, Cardoso, Rhanderson, additional, Blankstein, Ron, additional, Danad, Ibrahim, additional, Choi, Andrew D., additional, and Knaapen, Paul, additional

Published
2023
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21. The diagnostic performance of quantitative flow ratio and perfusion imaging in patients with prior coronary artery disease.

Author

Diemen, Pepijn A van, Winter, Ruben W de, Schumacher, Stefan P, Everaars, Henk, Bom, Michiel J, Jukema, Ruurt A, Somsen, Yvemarie B, Raijmakers, Pieter G, Kooistra, Rolf A, Timmer, Janny, Maaniitty, Teemu, Robbers, Lourens F, Bartheld, Martin B von, Demirkiran, Ahmet, Rossum, Albert C van, Reiber, Johan H, Knuuti, Juhani, Underwood, S Richard, Nagel, Eike, and Knaapen, Paul

Subjects
STATISTICS, RESEARCH, PERCUTANEOUS coronary intervention, CONFIDENCE intervals, OPERATIVE surgery, MAGNETIC resonance imaging, MYOCARDIAL infarction, RETROSPECTIVE studies, COMPARATIVE studies, CORONARY artery disease, POSITRON emission tomography, DESCRIPTIVE statistics, INTRACLASS correlation, PERFUSION imaging, DATA analysis software, DATA analysis, PERFUSION, CARDIAC-gated SPECT
Abstract

Aims In chronic coronary syndrome (CCS) patients with documented coronary artery disease (CAD), ischaemia detection by myocardial perfusion imaging (MPI) and an invasive approach are viable diagnostic strategies. We compared the diagnostic performance of quantitative flow ratio (QFR) with single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance imaging (CMR) in patients with prior CAD [previous percutaneous coronary intervention (PCI) and/or myocardial infarction (MI)]. Methods and results This PACIFIC-2 sub-study evaluated 189 CCS patients with prior CAD for inclusion. Patients underwent SPECT, PET, and CMR followed by invasive coronary angiography with fractional flow reserve (FFR) measurements of all major coronary arteries (N = 567), except for vessels with a sub-total or chronic total occlusion. Quantitative flow ratio computation was attempted in 488 (86%) vessels with measured FFR available (FFR ≤0.80 defined haemodynamically significant CAD). Quantitative flow ratio analysis was successful in 334 (68%) vessels among 166 patients and demonstrated a higher accuracy (84%) and sensitivity (72%) compared with SPECT (66%, P < 0.001 and 46%, P = 0.001), PET (65%, P < 0.001 and 58%, P = 0.032), and CMR (72%, P < 0.001 and 33%, P < 0.001). The specificity of QFR (87%) was similar to that of CMR (83%, P = 0.123) but higher than that of SPECT (71%, P < 0.001) and PET (67%, P < 0.001). Lastly, QFR exhibited a higher area under the receiver operating characteristic curve (0.89) than SPECT (0.57, P < 0.001), PET (0.66, P < 0.001), and CMR (0.60, P < 0.001). Conclusion QFR correlated better with FFR in patients with prior CAD than MPI, as reflected in the higher diagnostic performance measures for detecting FFR-defined, vessel-specific, significant CAD. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Impact of percutaneous coronary intervention of chronic total occlusions on absolute perfusion in remote myocardium

Author

de Winter, Ruben W., Schumacher, Stefan P., van Diemen, Pepijn A., Jukema, Ruurt A., Somsen, Yvemarie B. O., Stuijfzand, Wynand J., Driessen, Roel S., Bom, Michiel J., Everaars, Henk, van Rossum, Albert C., van de Ven, Peter M., Opolski, Maksymilian P., Verouden, Niels J., Danad, Ibrahim, Raijmakers, Pieter G., Nap, Alex, Knaapen, Paul, Cardiology, ACS - Heart failure & arrhythmias, ACS - Atherosclerosis & ischemic syndromes, Radiology and nuclear medicine, AII - Infectious diseases, and AMS - Tissue Function & Regeneration

Subjects
Perfusion, Percutaneous Coronary Intervention, Treatment Outcome, Coronary Occlusion, Coronary Circulation, Myocardium, Chronic Disease, Myocardial Perfusion Imaging, Humans, Hyperemia, Coronary Angiography, Cardiology and Cardiovascular Medicine
Abstract

Background: Revascularisation of a chronic total coronary occlusion (CTO) impacts on the coronary physiology of the remote myocardial territory. Aims: This study aimed to evaluate the intrinsic effect of CTO percutaneous coronary intervention (PCI) on changes in absolute perfusion in remote myocardium. Methods: A total of 164 patients who underwent serial [ 15O]H 2O positron emission tomography (PET) perfusion imaging at baseline and three months after successful single-vessel CTO PCI were included to evaluate changes in hyperaemic myocardial blood flow (hMBF) and coronary flow reserve (CFR) in the remote myocardium supplied by both non-target coronary arteries. Results: Perfusion indices in CTO and remote myocardium showed a positive correlation before (resting MBF: r=0.84, hMBF: r =0.75, and CFR: r =0.77, p–1·g –1 and from 2.48±0.76 to 2.74±0.85, respectively, p

Published
2022

24. HIGH DIAGNOSTIC ACCURACY OF AI-ISCHEMIA IN COMPARISON TO PET, FFR-CT, SPECT, AND INVASIVE FFR: A PACIFIC SUB-STUDY

Author

Nurmohamed, Nick S., primary, Danad, Ibrahim, additional, Jukema, Ruurt, additional, Driessen, Roel, additional, Bom, Michiel, additional, Winter, Ruben Willem De, additional, Sprengers, Ralf, additional, Katz, Richard J., additional, Cantlay, Catherine, additional, Knuuti, Juhani M., additional, Min, James K., additional, Earls, James P., additional, Choi, Andrew D., additional, and Knaapen, Paul, additional

Published
2023
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25. QUANTITATIVE PLAQUE STAGING SYSTEM PREDICTS LONG-TERM CARDIOVASCULAR OUTCOMES IN PATIENTS AT RISK FOR ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Author

Nurmohamed, Nick S., primary, Bom, Michiel, additional, Jukema, Ruurt, additional, De Groot, Robin, additional, Driessen, Roel, additional, Van Diemen, Pepijn, additional, Sprengers, Ralf, additional, Min, James K., additional, Earls, James P., additional, Danad, Ibrahim, additional, Choi, Andrew D., additional, and Knaapen, Paul, additional

Published
2023
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26. AI-QCT DEMONSTRATES SUPERIOR ACCURACY FOR THE DIAGNOSIS OF OBSTRUCTIVE CAD BY QCA STANDARD COMPARED TO CORE LAB CCTA INTERPRETATION

Author

Nurmohamed, Nick S., primary, Jukema, Ruurt, additional, Driessen, Roel, additional, Bom, Michiel, additional, Winter, Ruben Willem De, additional, Sprengers, Ralf, additional, Nap, Alexander, additional, Sidahmed, Alfateh, additional, Min, James K., additional, Earls, James P., additional, Choi, Andrew D., additional, Knaapen, Paul, additional, and Danad, Ibrahim, additional

Published
2023
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28. Diabetes, Atherosclerosis, and Stenosis by AI

Author

Jonas, Rebecca A., primary, Crabtree, Tami R., additional, Jennings, Robert S., additional, Marques, Hugo, additional, Katz, Richard J., additional, Chang, Hyuk-Jae, additional, Stuijfzand, Wijnand J., additional, van Rosendael, Alexander R., additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Park, Hyung-Bok, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, Knaapen, Paul, additional, de Waard, Guus A., additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Al-Mallah, Mouaz H., additional, Guglielmo, Marco, additional, Bax, Jeroen J., additional, Earls, James P., additional, Min, James K., additional, Choi, Andrew D., additional, and Villines, Todd C., additional

Published
2023
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30. Diabetes, Atherosclerosis and Stenosis by AI

Author

Jonas, Rebecca A., primary, Earls, James P., primary, Marques, Hugo, primary, Katz, Richard J., primary, Chang, Hyuk-Jae, primary, Choi, Jung Hyun, primary, Doh, Joon-Hyung, primary, Her, Ae-Young, primary, Koo, Bon-Kwon, primary, Nam, Chang-Wook, primary, Park, Hyung-Bok, primary, Shin, Sang-Hoon, primary, Cole, Jason, primary, Gimelli, Alessia, primary, Khan, Muhammad Akram, primary, Lu, Bin, primary, Gao, Yang, primary, Nabi, Faisal, primary, Nakazato, Ryo, primary, Schoepf, U. Joseph, primary, Driessen, Roel S., primary, Bom, Michiel J., primary, Thompson, Randall C., primary, Jang, James J., primary, Ridner, Michael, primary, Rowan, Chris, primary, Avelar, Erick, primary, Généreux, Philippe, primary, Knaapen, Paul, primary, Waard, Guus A. de, primary, Pontone, Gianluca, primary, Andreini, Daniele, primary, Al-Mallah, Mouaz H., primary, Guglielmo, Marco, primary, Jennings, Robert S., primary, Crabtree, Tami R., primary, Min, James K., primary, Choi, Andrew D., primary, and Villines, Todd C., primary

Published
2022
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31. Coronary CTA With AI-QCT Interpretation: Comparison With Myocardial Perfusion Imaging for Detection of Obstructive Stenosis Using Invasive Angiography as Reference Standard

Author

Lipkin, Isabella, primary, Telluri, Anha, additional, Kim, Yumin, additional, Sidahmed, Alfateh, additional, Krepp, Joseph M., additional, Choi, Brian G., additional, Jonas, Rebecca, additional, Marques, Hugo, additional, Chang, Hyuk-Jae, additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Park, Hyung-Bok, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, Knaapen, Paul, additional, de Waard, Guus A., additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Al-Mallah, Mouaz H., additional, Crabtree, Tami R., additional, Earls, James P., additional, Choi, Andrew D., additional, and Min, James K., additional

Published
2022
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33. Comparison between cardiac magnetic resonance stress T1 mapping and [O-15]H2O positron emission tomography in patients with suspected obstructive coronary artery disease

Author

Everaars, Henk, Diemen, Pepijn A. van, Stefan Biesbroek, P., Hopman, Luuk H.G.A., Bom, Michiel J., Schumacher, Stefan P., Nijveldt, R., Driessen, Roel S., Knaapen, Paul, Everaars, Henk, Diemen, Pepijn A. van, Stefan Biesbroek, P., Hopman, Luuk H.G.A., Bom, Michiel J., Schumacher, Stefan P., Nijveldt, R., Driessen, Roel S., and Knaapen, Paul

Abstract

Contains fulltext : 247917.pdf (Publisher’s version ) (Closed access)

Published
2022

34. Advances in coronary CT angiography and PET perfusion imaging for the detection of coronary artery disease

Author

Bom, Michiel Jeroen and Bom, Michiel Jeroen

Abstract

The diagnostic work-up of patients with suspected CAD involves a clinical evaluation estimating the probability of disease followed by a non-invasive imaging test. A myriad of non-invasive imaging modalities are available for this purpose and can be roughly divided into two groups, i.e. anatomical testing with coronary computed tomography angiography (CCTA) or functional testing using exercise testing or myocardial perfusion imaging. The aim of this thesis was to improve the diagnostic work-up of patients with suspected CAD through the investigation of advances in CCTA (Part I), [15O]H2O PET perfusion imaging (part II) and hybrid imaging (part III). Anatomical imaging using CCTA has emerged as one of the most widely used imaging modalities and both previous studies and studies from this thesis have demonstrated great diagnostic and prognostic performance of stenosis grading using CCTA. Studies from this thesis have shown that novel parameters obtained through post-processing of standard CCTA data, such as plaque measures, subtended myocardial mass, FFRCT and pericoronary fat attenuation may improve diagnostic and prognostic performance of CCTA. In addition to its role in the diagnostic work-up of patients with suspected CAD, a study from this thesis has demonstrated the feasibility of using CCTA for PCI procedural planning. Quantitative perfusion imaging using [15O]H2O PET has also gained great interest in the last decades. Previous studies and studies from this thesis have shown excellent diagnostic and prognostic performance of [15O]H2O PET-derived absolute quantification of myocardial blood flow. However, the addition of the longitudinal flow gradient to absolute myocardial blood flow did not improve the diagnostic performance of PET perfusion. Hybrid imaging with PET/CT has been proposed to combine the strengths and overcome the limitations of both separate techniques. Although recent studies and a study from this thesis have questioned the diagnostic potential

Published
2022

35. The effect of scan and patient parameters on the diagnostic performance of AI for detecting coronary stenosis on coronary CT angiography

Author

Jonas, Rebecca, Barkovich, Emil, Choi, Andrew D, Griffin, William F, Riess, Joanna, Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U Joseph, Driessen, Roel S, Bom, Michiel J, Thompson, Randall C, Jang, James J, Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A, Pontone, Gianluca, Andreini, Daniele, Guglielmo, Marco, Al-Mallah, Mouaz H, Jennings, Robert S, Crabtree, Tami R, Earls, James P, Jonas, Rebecca, Barkovich, Emil, Choi, Andrew D, Griffin, William F, Riess, Joanna, Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U Joseph, Driessen, Roel S, Bom, Michiel J, Thompson, Randall C, Jang, James J, Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A, Pontone, Gianluca, Andreini, Daniele, Guglielmo, Marco, Al-Mallah, Mouaz H, Jennings, Robert S, Crabtree, Tami R, and Earls, James P

Abstract

Objectives: To determine whether coronary computed tomography angiography (CCTA) scanning, scan preparation, contrast, and patient based parameters influence the diagnostic performance of an artificial intelligence (AI) based analysis software for identifying coronary lesions with ≥50% stenosis. Background: CCTA is a noninvasive imaging modality that provides diagnostic and prognostic benefit to patients with coronary artery disease (CAD). The use of AI enabled quantitative CCTA (AI-QCT) analysis software enhances our diagnostic and prognostic ability, however, it is currently unclear whether software performance is influenced by CCTA scanning parameters. Methods: CCTA and quantitative coronary CT (QCT) data from 303 stable patients (64 ± 10 years, 71% male) from the derivation arm of the CREDENCE Trial were retrospectively analyzed using an FDA-cleared cloud-based software that performs AI-enabled coronary segmentation, lumen and vessel wall determination, plaque quantification and characterization, and stenosis determination. The algorithm's diagnostic performance measures (sensitivity, specificity, and accuracy) for detecting coronary lesions of ≥50% stenosis were determined based on concordance with QCA measurements and subsequently compared across scanning parameters (including scanner vendor, model, single vs dual source, tube voltage, dose length product, gating technique, timing method), scan preparation technique (use of beta blocker, use and dose of nitroglycerin), contrast administration parameters (contrast type, infusion rate, iodine concentration, contrast volume) and patient parameters (heart rate and BMI). Results: Within the patient cohort, 13% demonstrated ≥50% stenosis in 3 vessel territories, 21% in 2 vessel territories, 35% in 1 vessel territory while 32% had <50% stenosis in all vessel territories evaluated by QCA. Average AI analysis time was 10.3 ± 2.7 min. On a per vessel basis, there were significant differences only in sensitivity for ≥50%

Published
2022

36. Targeted proteomics improves cardiovascular risk prediction in secondary prevention

Author

Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Circulatory Health, Infection & Immunity, Interne Geneeskunde Vasculaire, Nurmohamed, Nick S., Belo Pereira, João P., Hoogeveen, Renate M., Kroon, Jeffrey, Kraaijenhof, Jordan M., Waissi, Farahnaz, Timmerman, Nathalie, Bom, Michiel J., Hoefer, Imo E., Knaapen, Paul, Catapano, Alberico L., Koenig, Wolfgang, de Kleijn, Dominique, Visseren, Frank L.J., Levin, Evgeni, Stroes, Erik S.G., Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Circulatory Health, Infection & Immunity, Interne Geneeskunde Vasculaire, Nurmohamed, Nick S., Belo Pereira, João P., Hoogeveen, Renate M., Kroon, Jeffrey, Kraaijenhof, Jordan M., Waissi, Farahnaz, Timmerman, Nathalie, Bom, Michiel J., Hoefer, Imo E., Knaapen, Paul, Catapano, Alberico L., Koenig, Wolfgang, de Kleijn, Dominique, Visseren, Frank L.J., Levin, Evgeni, and Stroes, Erik S.G.

Published
2022

37. IMPACT OF PERCUTANEOUS CORONARY INTERVENTION OF CHRONIC TOTAL OCCLUSIONS ON ABSOLUTE PERFUSION IN REMOTE MYOCARDIUM

Author

De Winter, Ruben Willem, primary, Schumacher, Stefan, additional, Van Diemen, Pepijn, additional, Jukema, Ruurt, additional, Somsen, Yvemarie, additional, Stuijfzand, Wynand, additional, Driessen, Roel, additional, Bom, Michiel, additional, Everaars, Henk, additional, van Rossum, Albert, additional, van de Ven, Peter, additional, Opolski, Maksymilian, additional, Verouden, Niels, additional, Danad, Ibrahim, additional, Raijmakers, Pieter, additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2022
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38. TARGETED PROTEOMICS IMPROVES CARDIOVASCULAR RISK PREDICTION IN SECONDARY PREVENTION PATIENTS

Author

Nurmohamed, Nick S., primary, Pereira, Joao P. Belo, additional, Hoogeveen, Renate M., additional, Kroon, Jeffrey, additional, Kraaijenhof, Jordan M., additional, Waissi, Farahnaz, additional, Timmerman, Nathalie, additional, Bom, Michiel, additional, Hoefer, Imo, additional, Knaapen, Paul, additional, Catapano, Alberico L., additional, Koenig, Wolfgang, additional, de Kleijn, Dominique, additional, Visseren, Frank, additional, Levin, Evgeni, additional, and Stroes, Erik S.G., additional

Published
2022
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39. THE DIAGNOSTIC PERFORMANCE OF QFR AND MYOCARDIAL PERFUSION IMAGING IN PATIENTS WITH PRIOR CORONARY ARTERY DISEASE.

Author

Van Diemen, Pepijn, primary, De Winter, Ruben Willem, additional, Schumacher, Stefan, additional, Everaars, Henk, additional, Bom, Michiel, additional, Jukema, Ruurt, additional, Somsen, Yvemarie, additional, Raijmakers, Pieter, additional, Kooistra, Rolf A., additional, Timmer, Janny, additional, Maaniitty, Teemu, additional, Robbers, Lourens FHJ, additional, Bartheld, Bob von, additional, Demirkiran, Ahmet, additional, van Rossum, Albert, additional, Reiber, Johan H.C., additional, Knuuti, Juhani M., additional, Underwood, Stephen Richard, additional, Nagel, Eike C., additional, Knaapen, Paul, additional, Driessen, Roel, additional, and Danad, Ibrahim, additional

Published
2022
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40. CONCORDANT LOW AND DISCORDANT FRACTIONAL FLOW RESERVE AND INSTANTANEOUS WAVE-FREE RATIO MEASUREMENTS ARE ASSOCIATED WITH REDUCED MYOCARDIAL PERFUSION:A COMPARISON BETWEEN PRESSURE RATIO MEASUREMENTS AND 15O-WATER PET PERFUSION IMAGING

Author

De Winter, Ruben Willem, primary, Van Diemen, Pepijn, additional, Schumacher, Stefan, additional, Jukema, Ruurt, additional, Somsen, Yvemarie, additional, Bom, Michiel, additional, Everaars, Henk, additional, van Rossum, Albert, additional, Verouden, Niels, additional, Raijmakers, Pieter, additional, Nap, Alexander, additional, Driessen, Roel, additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2022
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41. Targeted proteomics improves cardiovascular risk prediction in secondary prevention

Author

Nurmohamed, Nick S., primary, Belo Pereira, João P., additional, Hoogeveen, Renate M., additional, Kroon, Jeffrey, additional, Kraaijenhof, Jordan M., additional, Waissi, Farahnaz, additional, Timmerman, Nathalie, additional, Bom, Michiel J., additional, Hoefer, Imo E., additional, Knaapen, Paul, additional, Catapano, Alberico L., additional, Koenig, Wolfgang, additional, de Kleijn, Dominique, additional, Visseren, Frank L.J., additional, Levin, Evgeni, additional, and Stroes, Erik S.G., additional

Published
2022
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42. The impact of coronary revascularization on vessel-specific coronary flow capacity and long-term outcomes: a serial [15O]H2O positron emission tomography perfusion imaging study

Author

de Winter, Ruben W, primary, Jukema, Ruurt A, additional, van Diemen, Pepijn A, additional, Schumacher, Stefan P, additional, Driessen, Roel S, additional, Stuijfzand, Wynand J, additional, Everaars, Henk, additional, Bom, Michiel J, additional, van Rossum, Albert C, additional, van de Ven, Peter M, additional, Verouden, Niels J, additional, Nap, Alexander, additional, Raijmakers, Pieter G, additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2021
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43. Abstract 10176: Absolute Perfusion Increase in Remote Myocardium Following Chronic Total Coronary Occlusion Percutaneous Coronary Intervention

Author

de Winter, Ruben W, primary, Schumacher, Stefan P, additional, van Diemen, Pepijn A, additional, Jukema, Ruurt A, additional, Somsen, Yvemarie B, additional, Stuijfzand, Wijnand J, additional, Driessen, Roel S, additional, Bom, Michiel J, additional, Everaars, Henk, additional, Van Rossum, Albert C. C, additional, van de Ven, Peter M, additional, Verouden, Niels J, additional, Danad, Ibrahim, additional, Raijmakers, Pieter G, additional, Alexander, Nap, additional, and Knaapen, Paul, additional

Published
2021
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44. Relationship of age, atherosclerosis and angiographic stenosis using artificial intelligence

Author

Jonas, Rebecca, primary, Earls, James, additional, Marques, Hugo, additional, Chang, Hyuk-Jae, additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon Kwon, additional, Nam, Chang-Wook, additional, Park, Hyung-Bok, additional, Shin, Sanghoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Nakazato, Ryo, additional, Schoepf, U Joseph, additional, Driessen, Roel S, additional, Bom, Michiel J, additional, Thompson, Randall C, additional, Jang, James J, additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, Knaapen, Paul, additional, de Waard, Guus A, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Al-Mallah, Mouaz H, additional, Jennings, Robert, additional, Crabtree, Tami R, additional, Villines, Todd C, additional, Min, James K, additional, and Choi, Andrew D, additional

Published
2021
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46. Residual Quantitative Flow Ratio to Estimate Post‐Percutaneous Coronary Intervention Fractional Flow Reserve

Author

van Diemen, Pepijn A., primary, de Winter, Ruben W., additional, Schumacher, Stefan P., additional, Bom, Michiel J., additional, Driessen, Roel S., additional, Everaars, Henk, additional, Jukema, Ruurt A., additional, Somsen, Yvemarie B., additional, Popelkova, Lenka, additional, van de Ven, Peter M., additional, van Rossum, Albert C., additional, van de Hoef, Tim P., additional, de Haan, Stefan, additional, Marques, Koen M., additional, Lemkes, Jorrit S., additional, Appelman, Yolande, additional, Nap, Alexander, additional, Verouden, Niels J., additional, Opolski, Maksymilian P., additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2021
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47. Prognostic Value of RCA Pericoronary Adipose Tissue CT-Attenuation Beyond High-Risk Plaques, Plaque Volume, and Ischemia

Author

van Diemen, Pepijn A., primary, Bom, Michiel J., additional, Driessen, Roel S., additional, Schumacher, Stefan P., additional, Everaars, Henk, additional, de Winter, Ruben W., additional, van de Ven, Peter M., additional, Freiman, Moti, additional, Goshen, Liran, additional, Heijtel, Dennis, additional, Langzam, Eran, additional, Min, James K., additional, Leipsic, Jonathon A., additional, Raijmakers, Pieter G., additional, van Rossum, Albert C., additional, Danad, Ibrahim, additional, and Knaapen, Paul, additional

Published
2021
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48. Viability and functional recovery after chronic total occlusion percutaneous coronary intervention

Author

Schumacher, Stefan P., primary, Everaars, Henk, additional, Stuijfzand, Wijnand J., additional, Diemen, Pepijn A., additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Winter, Ruben W., additional, Somsen, Yvemarie B. O., additional, Huynh, Jennifer W., additional, Loon, Ramon B., additional, Ven, Peter M., additional, Rossum, Albert C., additional, Opolski, Maksymilian P., additional, Nap, Alexander, additional, and Knaapen, Paul, additional

Published
2021
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49. Relationship of age, atherosclerosis and angiographic stenosis using artificial intelligence

Author

Jonas, Rebecca, Earls, James, Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sanghoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U Joseph, Driessen, Roel S, Bom, Michiel J, Thompson, Randall C, Jang, James J, Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A, Pontone, Gianluca, Andreini, Daniele, Al-Mallah, Mouaz H, Jennings, Robert, Crabtree, Tami R, Villines, Todd C, Min, James K, Choi, Andrew D, Jonas, Rebecca, Earls, James, Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sanghoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U Joseph, Driessen, Roel S, Bom, Michiel J, Thompson, Randall C, Jang, James J, Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A, Pontone, Gianluca, Andreini, Daniele, Al-Mallah, Mouaz H, Jennings, Robert, Crabtree, Tami R, Villines, Todd C, Min, James K, and Choi, Andrew D

Abstract

Objective: The study evaluates the relationship of coronary stenosis, atherosclerotic plaque characteristics (APCs) and age using artificial intelligence enabled quantitative coronary computed tomographic angiography (AI-QCT). Methods: This is a post-hoc analysis of data from 303 subjects enrolled in the CREDENCE (Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia) trial who were referred for invasive coronary angiography and subsequently underwent coronary computed tomographic angiography (CCTA). In this study, a blinded core laboratory analysing quantitative coronary angiography images classified lesions as obstructive (≥50%) or non-obstructive (<50%) while AI software quantified APCs including plaque volume (PV), low-density non-calcified plaque (LD-NCP), non-calcified plaque (NCP), calcified plaque (CP), lesion length on a per-patient and per-lesion basis based on CCTA imaging. Plaque measurements were normalised for vessel volume and reported as % percent atheroma volume (%PAV) for all relevant plaque components. Data were subsequently stratified by age <65 and ≥65 years. Results: The cohort was 64.4±10.2 years and 29% women. Overall, patients >65 had more PV and CP than patients <65. On a lesion level, patients >65 had more CP than younger patients in both obstructive (29.2 mm3 vs 48.2 mm3; p<0.04) and non-obstructive lesions (22.1 mm3 vs 49.4 mm3; p<0.004) while younger patients had more %PAV (LD-NCP) (1.5% vs 0.7%; p<0.038). Younger patients had more PV, LD-NCP, NCP and lesion lengths in obstructive compared with non-obstructive lesions. There were no differences observed between lesion types in older patients. Conclusion: AI-QCT identifies a unique APC signature that differs by age and degree of stenosis and provides a foundation for AI-guided age-based approaches to atherosclerosis identification, prevention and treatment.

Published
2021

50. Comparison between cardiac magnetic resonance stress T1 mapping and [15O]H2O positron emission tomography in patients with suspected obstructive coronary artery disease

Author

Everaars, Henk, primary, van Diemen, Pepijn A, additional, Biesbroek, P Stefan, additional, Hopman, Luuk H G A, additional, Bom, Michiel J, additional, Schumacher, Stefan P, additional, de Winter, Ruben W, additional, van de Ven, Peter M, additional, Raijmakers, Pieter G, additional, Lammertsma, Adriaan A, additional, Hofman, Mark B M, additional, Nijveldt, Robin, additional, Götte, Marco J, additional, van Rossum, Albert C, additional, Danad, Ibrahim, additional, Driessen, Roel S, additional, and Knaapen, Paul, additional

Published
2021
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