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Brain oxidative signaling pathways have been identified as important targets for alleviating food deprivation-induced changes in metabolic gate-ways. Previous studies have shown that prenatal and early postnatal malnutrition alters leptin and ghrelin signaling via oxidative pathways. Thus, it has been hypothesized that agents with antioxidant properties might be beneficial for the mitigation of prenatal and early postnatal food scarcity-induced oxidative damage. Quercetin and kaempferol are natural bioflavonoids with proven antioxidant properties. In this study, we evaluated their effects on prenatal maternal food consumption, maternal and pup weights, biomarkers of orexigenic and anorexigenic hormones and oxidative stress in rats. Rats were allotted into different treatment groups (n ​= ​6) in three different experiments (prenatal, postnatal food-deprivations or both). Prenatal-food restriction (PrNFR) was induced by 50% of ad libitum accessible diet during pregnancy till parturition and postnatal-food restriction (PsNFR) was simulated by litter-enlargement to 16 pups per mother from postnatal day (PND) 2. Rats in each experiment were concurrently treated with vehicle (10 ​mL/kg), quercetin (50, 100 and 200 ​mg/kg, p.o.) or kaempferol (50, 100 and 200 ​mg/kg, p.o.) respectively. A third experimental group consisted of both protocols. Quercetin and kaempferol dose-dependently increased the body weights of pups exposed to PrNFR, PsNFR and PrNFR-PsNFR at PNDs 1–22 respectively. Both compounds increased maternal body weights but attenuated maternal food-intake at prenatal days 7 and 14 due by PrNFR. Quercetin and kaempferol reduced brain malondialdehyde concentrations and increased glutathione levels in PrNFR, PsNFR and PrNFR-PsNFR-exposed offspring of rats. Importantly, quercetin and kaempferol significantly (p ​, Highlights • PrNFR and PsNFR reduce maternal and fetal weights. • Quercetine and kaempferol increase PrNFR and PsNFR-induced weight loss. • Quercetine and kaempferol attenuate PrNFR and PsNFR-induced ghrelin alteration. • Quercetine and kaempferol attenuate PrNFR and PsNFR-induced leptin alteration. • Quercetine and kaempferol reduced PrNFR and PsNFR-induced brain oxidative stress., Graphical abstract Image 1

The state of Nigeria as regards the effect of trade openness on industrialization is a major concern. This research helps to evaluate this effect. The variables show a long-run relationship, using Bound Cointegration test. The final analytical result was gotten using ARDL (Auto-Regressive Distributed Lag) Co-integration and Long-run form. The results show that trade openness is not significant, and it is negatively related to industrialization. The implication of this is that it hinders industrialization in Nigeria. This is due to excess importation and infrastructure deficit, alongside other factors. The study recommended that existing policies should not be waved aside; there should be engagement in international industrial competitiveness, and stabilization of exchange rate.