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1. Cerebral Palsy Phenotypes in Genetic Epilepsies

Author

Moufawad El Achkar, Christelle, Bergin, Ann, Bolton, Jeffrey, Ghosh, Partha, Harini, Chellamani, Libenson, Mark, Lieberman, David, Loddenkemper, Tobias, Olson, Heather, Patel, Archana, Pearl, Phillip L., Pinto, Anna, Rotenberg, Alexander, Yuskaitis, Christopher, Srivastava, Siddharth, Koh, Hyun Yong, Smith, Lacey, and Poduri, Annapurna

Published
2024
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2. Pediatric Palliative Epilepsy Surgery: A Report From the Pediatric Epilepsy Research Consortium (PERC) Surgery Database

Author

Jeno, Mary, Zimmerman, M. Bridget, Shandley, Sabrina, Wong-Kisiel, Lily, Singh, Rani Kaur, McNamara, Nancy, Fedak Romanowski, Erin, Grinspan, Zachary M., Eschbach, Krista, Alexander, Allyson, McGoldrick, Patricia, Wolf, Steven, Nangia, Srishti, Bolton, Jeffrey, Olaya, Joffre, Shrey, Daniel W., Karia, Samir, Karakas, Cemal, Tatachar, Priyamvada, Ostendorf, Adam P., Gedela, Satyanarayana, Javarayee, Pradeep, Reddy, Shilpa, Manuel, Chad McNair, Gonzalez-Giraldo, Ernesto, Sullivan, Joseph, Coryell, Jason, Depositario-Cabacar, Dewi Frances Tonelete, Hauptman, Jason Scott, Samanta, Debopam, Armstrong, Dallas, Perry, Michael Scott, Marashly, Ahmad, and Ciliberto, Michael

Published
2024
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3. Comparison of the real‐world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug‐resistant epilepsy: A post hoc analysis of the HOPS study

Author

Fallah, Aria, Lewis, Evan, Ibrahim, George M, Kola, Olivia, Tseng, Chi‐Hong, Harris, William B, Chen, Jia‐Shu, Lin, Kao‐Min, Cai, Li‐Xin, Liu, Qing‐Zhu, Lin, Jiu‐Luan, Zhou, Wen‐Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy WR, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Steinbok, Paul, Zhang, Jian‐Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong‐Kisiel, Lily, Lapalme‐Remis, Samuel, Tripathi, Manjari, Chandra, Poodipedi Sarat, Hader, Walter, Wang, Feng‐Peng, Yao, Yi, Champagne, Pierre‐Olivier, Brunette‐Clément, Tristan, Guo, Qiang, Li, Shao‐Chun, Budke, Marcelo, Pérez‐Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Malone, Christian Cantillano, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al‐Khateeb, Mashael, Otaibi, Faisal Al, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, and Weil, Alexander G

Subjects
Neurodegenerative, Clinical Research, Epilepsy, Neurosciences, Brain Disorders, Clinical Trials and Supportive Activities, Child, Drug Resistant Epilepsy, Hemispherectomy, Humans, Pilot Projects, Prospective Studies, Retrospective Studies, Seizures, Treatment Outcome, hemispherectomy, hemispherotomy, seizure outcomes, technique, Clinical Sciences, Neurology & Neurosurgery
Abstract

ObjectiveThis study was undertaken to determine whether the vertical parasagittal approach or the lateral peri-insular/peri-Sylvian approach to hemispheric surgery is the superior technique in achieving long-term seizure freedom.MethodsWe conducted a post hoc subgroup analysis of the HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort study that identified predictors of seizure freedom through logistic regression modeling. Only patients undergoing vertical parasagittal, lateral peri-insular/peri-Sylvian, or lateral trans-Sylvian hemispherotomy were included in this post hoc analysis. Differences in seizure freedom rates were assessed using a time-to-event method and calculated using the Kaplan-Meier survival method.ResultsData for 672 participants across 23 centers were collected on the specific hemispherotomy approach. Of these, 72 (10.7%) underwent vertical parasagittal hemispherotomy and 600 (89.3%) underwent lateral peri-insular/peri-Sylvian or trans-Sylvian hemispherotomy. Seizure freedom was obtained in 62.4% (95% confidence interval [CI] = 53.5%-70.2%) of the entire cohort at 10-year follow-up. Seizure freedom was 88.8% (95% CI = 78.9%-94.3%) at 1-year follow-up and persisted at 85.5% (95% CI = 74.7%-92.0%) across 5- and 10-year follow-up in the vertical subgroup. In contrast, seizure freedom decreased from 89.2% (95% CI = 86.3%-91.5%) at 1-year to 72.1% (95% CI = 66.9%-76.7%) at 5-year to 57.2% (95% CI = 46.6%-66.4%) at 10-year follow-up for the lateral subgroup. Log-rank test found that vertical hemispherotomy was associated with durable seizure-free progression compared to the lateral approach (p = .01). Patients undergoing the lateral hemispherotomy technique had a shorter time-to-seizure recurrence (hazard ratio = 2.56, 95% CI = 1.08-6.04, p = .03) and increased seizure recurrence odds (odds ratio = 3.67, 95% CI = 1.05-12.86, p = .04) compared to those undergoing the vertical hemispherotomy technique.SignificanceThis pilot study demonstrated more durable seizure freedom of the vertical technique compared to lateral hemispherotomy techniques. Further studies, such as prospective expertise-based observational studies or a randomized clinical trial, are required to determine whether a vertical approach to hemispheric surgery provides superior long-term seizure outcomes.

Published
2021

4. A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3

Author

Acosta, Maria T., Adam, Margaret, Adams, David R., Alvarez, Raquel L., Alvey, Justin, Amendola, Laura, Andrews, Ashley, Ashley, Euan A., Bacino, Carlos A., Bademci, Guney, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H., Behrens, Edward, Bejerano, Gill, Bellen, Hugo J., Bennett, Jimmy, Berg-Rood, Beverly, Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonner, Devon, Botto, Lorenzo, Boyd, Brenna, Briere, Lauren C., Brown, Gabrielle, Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Byers, Peter, Byrd, William E., Carey, John, Carrasquillo, Olveen, Cassini, Thomas, Chang, Ta Chen Peter, Chanprasert, Sirisak, Chao, Hsiao-Tuan, Chinn, Ivan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Coggins, Matthew, Cole, F. Sessions, Colley, Heather A., Cope, Heidi, Corona, Rosario, Craigen, William J., Crouse, Andrew B., Cunningham, Michael, D’Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davis, Joie, Dayal, Jyoti G., Dell'Angelica, Esteban C., Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Doss, Argenia L., Douine, Emilie D., Earl, Dawn, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Falk, Marni, Fieg, Elizabeth L., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Gahl, William A., Glass, Ian, Gochuico, Bernadette, Goddard, Page C., Godfrey, Rena A., Golden-Grant, Katie, Grajewski, Alana, Hadley, Don, Hahn, Sihoun, Halley, Meghan C., Hamid, Rizwan, Hassey, Kelly, Hayes, Nichole, High, Frances, Hing, Anne, Hisama, Fuki M., Holm, Ingrid A., Hom, Jason, Horike-Pyne, Martha, Huang, Alden, Hutchison, Sarah, Introne, Wendy, Isasi, Rosario, Izumi, Kosuke, Jamal, Fariha, Jarvik, Gail P., Jarvik, Jeffrey, Jayadev, Suman, Jean-Marie, Orpa, Jobanputra, Vaidehi, Karaviti, Lefkothea, Ketkar, Shamika, Kiley, Dana, Kilich, Gonench, Kobren, Shilpa N., Kohane, Isaac S., Kohler, Jennefer N., Korrick, Susan, Kozuira, Mary, Krakow, Deborah, Krasnewich, Donna M., Kravets, Elijah, Lalani, Seema R., Lam, Byron, Lam, Christina, Lanpher, Brendan C., Lanza, Ian R., LeBlanc, Kimberly, Lee, Brendan H., Levitt, Roy, Lewis, Richard A., Liu, Pengfei, Liu, Xue Zhong, Longo, Nicola, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Maghiro, Audrey Stephannie, Mahoney, Rachel, Malicdan, May Christine V., Mamounas, Laura A., Manolio, Teri A., Mao, Rong, Maravilla, Kenneth, Marom, Ronit, Marth, Gabor, Martin, Beth A., Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, McCauley, Jacob, McConkie-Rosell, Allyn, McCray, Alexa T., McGee, Elisabeth, Mefford, Heather, Merritt, J. Lawrence, Might, Matthew, Mirzaa, Ghayda, Morava, Eva, Moretti, Paolo, Mulvihill, John, Nakano-Okuno, Mariko, Nelson, Stanley F., Newman, John H., Nicholas, Sarah K., Nickerson, Deborah, Nieves-Rodriguez, Shirley, Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pace, Laura, Pak, Stephen, Pallais, J. Carl, Palmer, Christina G.S., Papp, Jeanette C., Parker, Neil H., Phillips III, John A., Posey, Jennifer E., Potocki, Lorraine, Pusey Swerdzewski, Barbara N., Quinlan, Aaron, Rao, Deepak A., Raper, Anna, Raskind, Wendy, Renteria, Genecee, Reuter, Chloe M., Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rosenwasser, Natalie, Rossignol, Francis, Ruzhnikov, Maura, Sacco, Ralph, Sampson, Jacinda B., Saporta, Mario, Schaechter, Judy, Schedl, Timothy, Schoch, Kelly, Scott, Daryl A., Scott, C. Ron, Seto, Elaine, Shashi, Vandana, Shin, Jimann, Silverman, Edwin K., Sinsheimer, Janet S., Sisco, Kathy, Smith, Edward C., Smith, Kevin S., Solnica-Krezel, Lilianna, Solomon, Ben, Spillmann, Rebecca C., Stoler, Joan M., Sullivan, Kathleen, Sullivan, Jennifer A., Sun, Angela, Sutton, Shirley, Sweetser, David A., Sybert, Virginia, Tabor, Holly K., Tan, Queenie K.-G., Tan, Amelia L.M., Tarakad, Arjun, Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Ungar, Rachel A., Urv, Tiina K., Vanderver, Adeline, Velinder, Matt, Viskochil, Dave, Vogel, Tiphanie P., Wahl, Colleen E., Walker, Melissa, Wallace, Stephanie, Walley, Nicole M., Wambach, Jennifer, Wan, Jijun, Wang, Lee-kai, Wangler, Michael F., Ward, Patricia A., Wegner, Daniel, Weisz Hubshman, Monika, Wener, Mark, Wenger, Tara, Westerfield, Monte, Wheeler, Matthew T., Whitlock, Jordan, Wolfe, Lynne A., Worley, Kim, Xiao, Changrui, Yamamoto, Shinya, Yang, John, Zhang, Zhe, Zuchner, Stephan, Paul, Maimuna S., Michener, Sydney L., Pan, Hongling, Chan, Hiuling, Pfliger, Jessica M., Lerma, Vanesa C., Tran, Alyssa, Longley, Megan A., Weisz-Hubshman, Monika, Bekheirnia, Mir Reza, Bekheirnia, Nasim, Massingham, Lauren, Zech, Michael, Wagner, Matias, Engels, Hartmut, Cremer, Kirsten, Mangold, Elisabeth, Peters, Sophia, Trautmann, Jessica, Perne, Claudia, Mester, Jessica L., Guillen Sacoto, Maria J., Person, Richard, McDonnell, Pamela P., Cohen, Stacey R., Lusk, Laina, Cohen, Ana S.A., Le Pichon, Jean-Baptiste, Pastinen, Tomi, Zhou, Dihong, Engleman, Kendra, Racine, Caroline, Faivre, Laurence, Moutton, Sébastien, Denommé-Pichon, Anne-Sophie, Koh, Hyun Yong, Poduri, Annapurna, Bolton, Jeffrey, Knopp, Cordula, Julia Suh, Dong Sun, Maier, Andrea, Toosi, Mehran Beiraghi, Karimiani, Ehsan Ghayoor, Maroofian, Reza, Schaefer, Gerald Bradley, Ramakumaran, Vijayalakshmi, Vasudevan, Pradeep, Banos-Pinero, Benito, Pagnamenta, Alistair T., Prasad, Chitra, Osmond, Matthew, Schuhmann, Sarah, Vasileiou, Georgia, Russ-Hall, Sophie, Scheffer, Ingrid E., and Carvill, Gemma L.

Published
2024
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5. Epilepsy surgery in children with genetic etiologies: A prospective evaluation of current practices and outcomes

Author

Coryell, Jason, Singh, Rani, Ostendorf, Adam P, Eisner, Mariah, Alexander, Allyson, Eschbach, Krista, Shrey, Daniel W, Olaya, Joffre, Ciliberto, Michael A, Karakas, Cemal, Karia, Samir, McNamara, Nancy, Romanowski, Erin Fedak, Kheder, Ammar, Pradeep, Javarayee, Reddy, Shilpa B, McCormack, Michael J., Bolton, Jeffrey, Wolf, Steven, McGoldrick, Patricia, Hauptman, Jason S, Samanta, Debopam, Tatachar, Priya, Sullivan, Joseph, Auguste, Kurtis, Gonzalez-Giraldo, Ernesto, Marashly, Ahmad, Depositario-Cabacar, Dewi F., Wong-Kisiel, Lily C, and Perry, Scott

Published
2023
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6. Design and implementation of electronic health record common data elements for pediatric epilepsy: Foundations for a learning health care system.

Author

Grinspan, Zachary, Patel, Anup, Shellhaas, Renée, Berg, Anne, Axeen, Erika, Bolton, Jeffrey, Clarke, David, Coryell, Jason, Gaillard, William, Goodkin, Howard, Koh, Sookyong, Kukla, Alison, Mbwana, Juma, Morgan, Lindsey, Singhal, Nilika, Storey, Margaret, Yozawitz, Elissa, Abend, Nicholas, Fitzgerald, Mark, Fridinger, Sara, Helbig, Ingo, Massey, Shavonne, Prelack, Marisa, and Buchhalter, Jeffrey

Subjects
Common Data Elements, Comparative Effectiveness Research, Electronic Health Records, Epidemiological Monitoring, Epilepsy, Health Services Research, Humans, Implementation Science, Neurology, Outcome and Process Assessment, Health Care, Pediatrics, Quality Improvement
Abstract

OBJECTIVE: Common data elements (CDEs) are standardized questions and answer choices that allow aggregation, analysis, and comparison of observations from multiple sources. Clinical CDEs are foundational for learning health care systems, a data-driven approach to health care focused on continuous improvement of outcomes. We aimed to create clinical CDEs for pediatric epilepsy. METHODS: A multiple stakeholder group (clinicians, researchers, parents, caregivers, advocates, and electronic health record [EHR] vendors) developed clinical CDEs for routine care of children with epilepsy. Initial drafts drew from clinical epilepsy note templates, CDEs created for clinical research, items in existing registries, consensus documents and guidelines, quality metrics, and outcomes needed for demonstration projects. The CDEs were refined through discussion and field testing. We describe the development process, rationale for CDE selection, findings from piloting, and the CDEs themselves. We also describe early implementation, including experience with EHR systems and compatibility with the International League Against Epilepsy classification of seizure types. RESULTS: Common data elements were drafted in August 2017 and finalized in January 2020. Prioritized outcomes included seizure control, seizure freedom, American Academy of Neurology quality measures, presence of common comorbidities, and quality of life. The CDEs were piloted at 224 visits at 10 centers. The final CDEs included 36 questions in nine sections (number of questions): diagnosis (1), seizure frequency (9), quality of life (2), epilepsy history (6), etiology (8), comorbidities (2), treatment (2), process measures (5), and longitudinal history notes (1). Seizures are categorized as generalized tonic-clonic (regardless of onset), motor, nonmotor, and epileptic spasms. Focality is collected as epilepsy type rather than seizure type. Seizure frequency is measured in nine levels (all used during piloting). The CDEs were implemented in three vendor systems. Early clinical adoption included 1294 encounters at one center. SIGNIFICANCE: We created, piloted, refined, finalized, and implemented a novel set of clinical CDEs for pediatric epilepsy.

Published
2021

7. Responsive Neurostimulation in Drug-Resistant Pediatric Epilepsy: Findings From the Epilepsy Surgery Subgroup of the Pediatric Epilepsy Research Consortium

Author

Perry, M. Scott, Ostendorf, Adam, Wong-Kisiel, Lily, Romanowski, Erin Fedak, McNamara, Nancy, Tatachar, Priyamvada, Depositario-Cabacar, Dewi, Gaillard, William D., Oluigbo, Chima, Koop, Jennifer, Andrade-Machado, Rene, Javarayee, Pradeep, Alexander, Allyson L., Eschbach, Krista, Olaya, Joffre, Shrey, Daniel, Singh, Rani K., Grinspan, Zachary, Nangia, Srishti, Karia, Samir, Karakas, Cemal, Bolton, Jeffrey, Ciliberto, Michael, Auguste, Kurtis, Gonzalez-Giraldo, Ernesto, Numis, Adam, Sullivan, Joseph, Coryell, Jason, Gedela, Satya, Hauptman, Jason, Reddy, Shilpa B., McCormack, Michael J., Manuel, Chad M., Samanta, Debopam, Armstrong, Dallas, Marashly, Ahmad, Liu, Gang, Numis, Adam L., Wolf, Steven, and Auguste, Kurtis I.

Published
2023
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11. Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.

Author

Jahromi, Saeed, Matarrese, Margherita A.G., Fabbri, Lorenzo, Tamilia, Eleonora, Perry, M. Scott, Madsen, Joseph R., Bolton, Jeffrey, Stone, Scellig S.D., Pearl, Phillip L., and Papadelis, Christos

Subjects
PEOPLE with epilepsy, PROGNOSIS, BIOMARKERS, EPILEPSY, ELECTROENCEPHALOGRAPHY
Abstract

Objective: Interictal biomarkers are critical for identifying the epileptogenic focus. However, spikes and ripples lack specificity while fast ripples lack sensitivity. These biomarkers propagate from more epileptogenic onset to areas of spread. The pathophysiological mechanism of these propagations is elusive. Here, we examine zones where spikes and high frequency oscillations co‐occur (SHFO), the spatiotemporal propagations of spikes, ripples, and fast ripples, and evaluate the spike–ripple onset overlap (SRO) as an epilepsy biomarker. Methods: We retrospectively analyzed intracranial EEG data from 41 patients with drug‐resistant epilepsy. We mapped propagations of spikes, ripples, and fast ripples, and identified their onset and spread zones, as well as SHFO and SRO. We then estimated the SRO prognostic value in predicting surgical outcome and compared it to onset and spread zones of spike, ripple, and fast ripple propagations, and SHFO. Results: We detected spikes and ripples in all patients and fast ripples in 12 patients (29%). We observed spike and ripple propagations in 40 (98%) patients. Spike and ripple onsets overlapped in 35 (85%) patients. In good outcome patients, SRO showed higher specificity and precision (p < 0.05) in predicting resection compared to onset and zones of spikes, ripples, and SHFO. Only SRO resection predicted outcome (p = 0.01) with positive and negative predictive values of 82% and 57%, respectively. Interpretation: SRO is a specific and precise biomarker of the epileptogenic zone whose removal predicts outcome. SRO is present in most patients with drug‐resistant epilepsy. Such a biomarker may reduce prolonged intracranial monitoring and improve outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Adults with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations

Author

Mitchell, James W., primary, Sossi, Frieda, additional, Miller, Isabel, additional, Jaber, Paula Blancarte, additional, Das‐Gupta, Zofia, additional, Fialho, Luz Sousa, additional, Amos, Action, additional, Austin, Joan K., additional, Badzik, Scott, additional, Baker, Gus, additional, Zeev, Bruria Ben, additional, Bolton, Jeffrey, additional, Chaplin, John E., additional, Cross, J. Helen, additional, Chan, Derrick, additional, Gericke, Christian A., additional, Husain, Aatif M., additional, Lally, Lorraine, additional, Mbugua, Sharon, additional, Megan, Cassidy, additional, Mesa, Tomás, additional, Nuñez, Lilia, additional, von Oertzen, Tim J., additional, Perucca, Emilio, additional, Pullen, Angie, additional, Ronen, Gabriel M., additional, Sajatovic, Martha, additional, Singh, Mamta B., additional, Wilmshurst, Jo M., additional, Wollscheid, Leonie, additional, and Berg, Anne T., additional

Published
2024
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13. A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3

Author

Paul, Maimuna S., primary, Michener, Sydney L., additional, Pan, Hongling, additional, Chan, Hiuling, additional, Pfliger, Jessica M., additional, Rosenfeld, Jill A., additional, Lerma, Vanesa C., additional, Tran, Alyssa, additional, Longley, Megan A., additional, Lewis, Richard A., additional, Weisz-Hubshman, Monika, additional, Bekheirnia, Mir Reza, additional, Bekheirnia, Nasim, additional, Massingham, Lauren, additional, Zech, Michael, additional, Wagner, Matias, additional, Engels, Hartmut, additional, Cremer, Kirsten, additional, Mangold, Elisabeth, additional, Peters, Sophia, additional, Trautmann, Jessica, additional, Perne, Claudia, additional, Mester, Jessica L., additional, Guillen Sacoto, Maria J., additional, Person, Richard, additional, McDonnell, Pamela P., additional, Cohen, Stacey R., additional, Lusk, Laina, additional, Cohen, Ana S.A., additional, Le Pichon, Jean-Baptiste, additional, Pastinen, Tomi, additional, Zhou, Dihong, additional, Engleman, Kendra, additional, Racine, Caroline, additional, Faivre, Laurence, additional, Moutton, Sébastien, additional, Denommé-Pichon, Anne-Sophie, additional, Koh, Hyun Yong, additional, Poduri, Annapurna, additional, Bolton, Jeffrey, additional, Knopp, Cordula, additional, Julia Suh, Dong Sun, additional, Maier, Andrea, additional, Toosi, Mehran Beiraghi, additional, Karimiani, Ehsan Ghayoor, additional, Maroofian, Reza, additional, Schaefer, Gerald Bradley, additional, Ramakumaran, Vijayalakshmi, additional, Vasudevan, Pradeep, additional, Banos-Pinero, Benito, additional, Pagnamenta, Alistair T., additional, Prasad, Chitra, additional, Osmond, Matthew, additional, Schuhmann, Sarah, additional, Vasileiou, Georgia, additional, Russ-Hall, Sophie, additional, Scheffer, Ingrid E., additional, Carvill, Gemma L., additional, Mefford, Heather, additional, Bacino, Carlos A., additional, Lee, Brendan H., additional, and Chao (趙孝端), Hsiao-Tuan, additional

Published
2024
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14. Interictal EEG source connectivity to localize the epileptogenic zone in patients with drug‐resistant epilepsy: A machine learning approach

Author

Ntolkeras, Georgios, primary, Makaram, Navaneethakrishna, additional, Bernabei, Matteo, additional, De La Vega, Aime Cristina, additional, Bolton, Jeffrey, additional, Madsen, Joseph R., additional, Stone, Scellig S. D., additional, Pearl, Phillip L., additional, Papadelis, Christos, additional, Grant, Ellen P., additional, and Tamilia, Eleonora, additional

Published
2024
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15. Somatic Mosaicism in PIK3CA Variant Correlates With Stereoelectroencephalography-Derived Electrophysiology

Author

Phillips, H. Westley, primary, D'Gama, Alissa M., additional, Wang, Yilan, additional, Chahine, Yasmine, additional, Chiu, Michelle, additional, Swanson, Amanda C., additional, Ahtam, Banu, additional, Bolton, Jeffrey B., additional, Madsen, Joseph R., additional, Lee, Eunjung A., additional, Prabhu, Sanjay P., additional, Lidov, Hart G., additional, Papadakis, Joanna, additional, Huang, August Y., additional, Poduri, Annapurna, additional, Stone, Scellig S., additional, and Walsh, Christopher A., additional

Published
2024
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17. Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Infants, Children, and Adolescents with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations.

Author

Mitchell, James W., Sossi, Frieda, Miller, Isabel, Jaber, Paula Blancarte, Das‐Gupta, Zofia, Fialho, Luz Sousa, Amos, Action, Austin, Joan K., Badzik, Scott, Baker, Gus, Ben Zeev, Bruria, Bolton, Jeffrey, Chaplin, John E., Cross, J. Helen, Chan, Derrick, Gericke, Christian A., Husain, Aatif M., Lally, Lorraine, Mbugua, Sharon, and Megan, Cassidy

Subjects
HEALTH outcome assessment, CHILDREN with epilepsy, EPILEPSY, CHILDHOOD epilepsy, LANGUAGE acquisition, ADOLESCENCE, CHILDREN with developmental disabilities
Abstract

At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. The International Consortium for Health Outcomes Measurement (ICHOM) convened an international working group of experts in epilepsy, people with epilepsy, and their representatives to develop minimum sets of standardized outcomes and outcome measurement methods for clinical practice. Using modified Delphi consensus methods with consecutive rounds of online voting over 12 months, a core set of outcomes and corresponding measurement tool packages to capture the outcomes were identified for infants, children, and adolescents with epilepsy. Consensus methods identified 20 core outcomes. In addition to the outcomes identified for the ICHOM Epilepsy adult standard set, behavioral, motor, and cognitive/language development outcomes were voted as essential for all infants and children with epilepsy. The proposed set of outcomes and measurement methods will facilitate the implementation of the use of patient‐centered outcomes in daily practice. [ABSTRACT FROM AUTHOR]

Published
2024
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18. A Multi‐center Comparison of Surgical Technique for Corpus Callosotomy in Pediatric Drug Resistant Epilepsy

Author

Hansen, Daniel, primary, Shandley, Sabrina, additional, Olaya, Joffre, additional, Hauptman, Jason, additional, Auguste, Kurtis, additional, Ostendorf, Adam P., additional, Depositario‐Cabacar, Dewi F., additional, Wong‐Kisiel, Lily C., additional, Reddy, Shilpa B., additional, McCormack, Michael J., additional, Gonzalez‐Giraldo, Ernesto, additional, Sullivan, Joseph, additional, Javarayee, Pradeep, additional, Singh, Rani K., additional, Fedak Romanowski, Erin, additional, McNamara, Nancy A., additional, Ciliberto, Michael A., additional, Tatachar, Priya, additional, Shrey, Daniel W., additional, Karakas, Cemal, additional, Karia, Samir, additional, Kheder, Ammar, additional, Gedela, Satyanarayana, additional, Alexander, Allyson, additional, Eschbach, Krista, additional, Bolton, Jeffrey, additional, Marashly, Ahmad, additional, Wolf, Steven, additional, McGoldrick, Patricia, additional, Nangia, Srishti, additional, Grinspan, Zachary, additional, Coryell, Jason, additional, Samanta, Debopam, additional, Armstrong, Dallas, additional, and Perry, M. Scott, additional

Published
2023
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21. Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)

Author

Weil, Alexander G., primary, Dimentberg, Evan, additional, Lewis, Evan, additional, Ibrahim, George M., additional, Kola, Olivia, additional, Tseng, Chi‐Hong, additional, Chen, Jia‐Shu, additional, Lin, Kao‐Min, additional, Cai, Li‐Xin, additional, Liu, Qing‐Zhu, additional, Lin, Jiu‐Luan, additional, Zhou, Wen‐Jing, additional, Mathern, Gary W., additional, Smyth, Matthew D., additional, O'Neill, Brent R., additional, Dudley, Roy, additional, Ragheb, John, additional, Bhatia, Sanjiv, additional, Delev, Daniel, additional, Ramantani, Georgia, additional, Zentner, Josef, additional, Wang, Anthony C., additional, Dorfer, Christian, additional, Feucht, Martha, additional, Czech, Thomas, additional, Bollo, Robert J., additional, Issabekov, Galymzhan, additional, Zhu, Hongwei, additional, Connolly, Mary, additional, Steinbok, Paul, additional, Zhang, Jian‐Guo, additional, Zhang, Kai, additional, Hidalgo, Eveline Teresa, additional, Weiner, Howard L., additional, Wong‐Kisiel, Lily, additional, Lapalme‐Remis, Samuel, additional, Tripathi, Manjari, additional, Sarat Chandra, Poodipedi, additional, Hader, Walter, additional, Wang, Feng‐Peng, additional, Yao, Yi, additional, Champagne, Pierre Olivier, additional, Brunette‐Clément, Tristan, additional, Guo, Qiang, additional, Li, Shao‐Chun, additional, Budke, Marcelo, additional, Pérez‐Jiménez, Maria Angeles, additional, Raftopoulos, Christian, additional, Finet, Patrice, additional, Michel, Pauline, additional, Schaller, Karl, additional, Stienen, Martin N., additional, Baro, Valentina, additional, Cantillano Malone, Christian, additional, Pociecha, Juan, additional, Chamorro, Noelia, additional, Muro, Valeria L., additional, von Lehe, Marec, additional, Vieker, Silvia, additional, Oluigbo, Chima, additional, Gaillard, William D., additional, Al Khateeb, Mashael, additional, Al Otaibi, Faisal, additional, Krayenbühl, Niklaus, additional, Bolton, Jeffrey, additional, Pearl, Phillip L., additional, and Fallah, Aria, additional

Published
2023
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22. 38 Fine Motor Skills in Pediatric Frontal Lobe Epilepsy are Associated with Executive Dysfunction and ADHD Symptomatology

Author

Maiman, Moshe, primary, Berl, Madison, additional, Koop, Jennifer I, additional, Bearden, Donald J, additional, Boyer, Katrina, additional, Cooper, Crystal M, additional, Decrow, Amanda M, additional, Duong, Priscilla H., additional, Espe-Pfeifer, Patricia, additional, Gabriel, Marsha, additional, Hodges, Elise, additional, McNally, Kelly A, additional, Molnar, Andrew, additional, Olsen, Emily, additional, Ono, Kim E, additional, Patrick, Kristina E, additional, Paul, Brianna, additional, Romain, Jonathan, additional, Sepeta, Leigh N, additional, Stilp, Rebecca LH, additional, Wilkening, Greta N, additional, Zaccariello, Mike, additional, Zelko, Frank, additional, Vega, Clemente, additional, Moore, Trey, additional, Mulati, Szimonetta, additional, Pearl, Phillip, additional, Bolton, Jeffrey, additional, and Ailion, Alyssa, additional

Published
2023
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23. 41 Characterizing the Cognitive Profile of Pediatric Insular Epilepsy

Author

Mulati, Szimonetta, primary, Bolton, Jeffrey, additional, Moore, Trey, additional, Wilson, Brigitte, additional, Dam, Song, additional, Hornak, Alena, additional, Boyer, Katrina, additional, Vega, Clemente, additional, Tsuboyama, Melissa, additional, Maiman, Moshe, additional, and Pearl, Phillip L, additional

Published
2023
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25. The added value of Corpus Callosotomy following Vagus Nerve Stimulation in children with Lennox‐Gastaut Syndrome: A multicenter, multinational study

Author

Roth, Jonathan, primary, Bergman, Lottem, additional, Weil, Alexander G., additional, Brunette‐Clement, Tristan, additional, Weiner, Howard L., additional, Treiber, Jeffrey M., additional, Shofty, Ben, additional, Cukiert, Arthur, additional, Cukiert, Cristine Mella, additional, Tripathi, Manjari, additional, Chandra, Poodipedi Sarat, additional, Bollo, Robert J., additional, Machado, Hélio Rubens, additional, Santos, Marcelo Volpon, additional, Gaillard, William D., additional, Oluigbo, Chima O., additional, Ibrahim, George M., additional, Jallo, George I., additional, Shimony, Nir, additional, O'Neill, Brent R., additional, Budke, Marcelo, additional, Pérez‐Jiménez, María Ángeles, additional, Mangano, Francesco T., additional, Iwasaki, Masaki, additional, Iijima, Keiya, additional, Gonzalez‐Martinez, Jorge, additional, Kawai, Kensuke, additional, Ishishita, Yohei, additional, Elbabaa, Samer K., additional, Bello‐Espinosa, Luis, additional, Fallah, Aria, additional, Maniquis, Cassia A. B., additional, Ben‐Zvi, Ido, additional, Tisdall, Martin, additional, Panigrahi, Manas, additional, Jayalakshmi, Sita, additional, Blount, Jeffrey P., additional, Dorfmüller, Georg, additional, Bulteau, Christine, additional, Stone, Scellig S., additional, Bolton, Jeffrey, additional, and Uliel‐Sibony, Shimrit, additional

Published
2023
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27. Deep Learning-Based Visual Complexity Analysis of Electroencephalography Time-Frequency Images: Can It Localize the Epileptogenic Zone in the Brain?

Author

Makaram, Navaneethakrishna, Gupta, Sarvagya, Pesce, Matthew, Bolton, Jeffrey, Stone, Scellig, Haehn, Daniel, Pomplun, Marc, Papadelis, Christos, Pearl, Phillip, Rotenberg, Alexander, Grant, Patricia Ellen, and Tamilia, Eleonora

Subjects
DISTRIBUTION (Probability theory), TIME-frequency analysis, SUPPORT vector machines, CHILDREN with epilepsy, CHILDHOOD epilepsy
Abstract

In drug-resistant epilepsy, a visual inspection of intracranial electroencephalography (iEEG) signals is often needed to localize the epileptogenic zone (EZ) and guide neurosurgery. The visual assessment of iEEG time-frequency (TF) images is an alternative to signal inspection, but subtle variations may escape the human eye. Here, we propose a deep learning-based metric of visual complexity to interpret TF images extracted from iEEG data and aim to assess its ability to identify the EZ in the brain. We analyzed interictal iEEG data from 1928 contacts recorded from 20 children with drug-resistant epilepsy who became seizure-free after neurosurgery. We localized each iEEG contact in the MRI, created TF images (1–70 Hz) for each contact, and used a pre-trained VGG16 network to measure their visual complexity by extracting unsupervised activation energy (UAE) from 13 convolutional layers. We identified points of interest in the brain using the UAE values via patient- and layer-specific thresholds (based on extreme value distribution) and using a support vector machine classifier. Results show that contacts inside the seizure onset zone exhibit lower UAE than outside, with larger differences in deep layers (L10, L12, and L13: p < 0.001). Furthermore, the points of interest identified using the support vector machine, localized the EZ with 7 mm accuracy. In conclusion, we presented a pre-surgical computerized tool that facilitates the EZ localization in the patient's MRI without requiring long-term iEEG inspection. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Responsive Neurostimulation in Drug Resistant Pediatric Epilepsy: findings from the Epilepsy Surgery Subgroup of the Pediatric Epilepsy Research Consortium

Author

Singh, Rani K., primary, Eschbach, Krista, additional, Samanta, Debopam, additional, Perry, M. Scott, additional, Liu, Gang, additional, Alexander, Allyson L., additional, Wong-Kisiel, Lily, additional, Ostendorf, Adam, additional, Tatachar, Priyamvada, additional, Reddy, Shilpa B., additional, McCormack, Michael J., additional, Manuel, Chad M., additional, Gonzalez-Giraldo, Ernesto, additional, Numis, Adam L., additional, Wolf, Steven, additional, Karia, Samir, additional, Karakas, Cemal, additional, Olaya, Joffre, additional, Shrey, Daniel, additional, Auguste, Kurtis I., additional, Depositario-Cabacar, Dewi, additional, Romanowski, Erin Fedak, additional, McNamara, Nancy, additional, Gaillard, William D., additional, Oluigbo, Chima, additional, Koop, Jennifer, additional, Andrade-Machado, Rene, additional, Javarayee, Pradeep, additional, Singh, RaniK., additional, Grinspan, Zachary, additional, Nangia, Srishti, additional, Bolton, Jeffrey, additional, Ciliberto, Michael, additional, Auguste, Kurtis, additional, Numis, Adam, additional, Sullivan, Joseph, additional, Coryell, Jason, additional, Gedela, Satya, additional, Hauptman, Jason, additional, Armstrong, Dallas, additional, and Marashly, Ahmad, additional

Published
2023
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31. Stereoelectroencephalography followed by combined electrode removal and MRI-guided laser interstitial thermal therapy or open resection: a single-center series in pediatric patients with medically refractory epilepsy

Author

Slingerland, Anna L., primary, Chua, Melissa M. J., additional, Bolton, Jeffrey, additional, Staffa, Steven J., additional, Tsuboyama, Melissa, additional, Prabhu, Sanjay P., additional, Pearl, Phillip L., additional, Madsen, Joseph R., additional, and Stone, Scellig S. D., additional

Published
2022
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36. Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome

Author

Stone, Scellig S. D., primary, Park, Eun-Hyoung, additional, Bolton, Jeffrey, additional, Harini, Chellamani, additional, Libenson, Mark H., additional, Rotenberg, Alexander, additional, Takeoka, Masanori, additional, Tsuboyama, Melissa, additional, Pearl, Phillip L., additional, and Madsen, Joseph R., additional

Published
2022
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39. Mendelian etiologies identified with whole exome sequencing in cerebral palsy

Author

Chopra, Maya, primary, Gable, Dustin L., additional, Love‐Nichols, Jamie, additional, Tsao, Alexa, additional, Rockowitz, Shira, additional, Sliz, Piotr, additional, Barkoudah, Elizabeth, additional, Bastianelli, Lucia, additional, Coulter, David, additional, Davidson, Emily, additional, DeGusmao, Claudio, additional, Fogelman, David, additional, Huth, Kathleen, additional, Marshall, Paige, additional, Nimec, Donna, additional, Sanders, Jessica Solomon, additional, Shore, Benjamin J., additional, Snyder, Brian, additional, Stone, Scellig S. D., additional, Ubeda, Ana, additional, Watkins, Colyn, additional, Berde, Charles, additional, Bolton, Jeffrey, additional, Brownstein, Catherine, additional, Costigan, Michael, additional, Ebrahimi‐Fakhari, Darius, additional, Lai, Abbe, additional, O'Donnell‐Luria, Anne, additional, Paciorkowski, Alex R., additional, Pinto, Anna, additional, Pugh, John, additional, Rodan, Lance, additional, Roe, Eugene, additional, Swanson, Lindsay, additional, Zhang, Bo, additional, Kruer, Michael C., additional, Sahin, Mustafa, additional, Poduri, Annapurna, additional, and Srivastava, Siddharth, additional

Published
2022
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40. Surgical evaluation in children <3 years of age with drug‐resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays

Author

Perry, Michael Scott, primary, Shandley, Sabrina, additional, Perelman, Max, additional, Singh, Rani K., additional, Wong‐Kisiel, Lily, additional, Sullivan, Joseph, additional, Gonzalez‐Giraldo, Ernesto, additional, Romanowski, Erin Fedak, additional, McNamara, Nancy A., additional, Marashly, Ahmad, additional, Ostendorf, Adam P., additional, Alexander, Allyson, additional, Eschbach, Krista, additional, Bolton, Jeffrey, additional, Wolf, Steven, additional, McGoldrick, Patricia, additional, Depositario‐Cabacar, Dewi F., additional, Ciliberto, Michael A., additional, Gedela, Satyanarayana, additional, Sannagowdara, Kumar, additional, Karia, Samir, additional, Shrey, Daniel W., additional, Tatachar, Priya, additional, Nangia, Srishti, additional, Grinspan, Zachary, additional, Reddy, Shilpa B., additional, Shital, Patel, additional, and Coryell, Jason, additional

Published
2021
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42. Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Centre du cancer, Fallah, Aria, Lewis, Evan, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Harris, William B, Chen, Jia-Shu, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy W R, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Champagne, Pierre-Olivier, Brunette-Clément, Tristan, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al-Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, Weil, Alexander G, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Centre du cancer, Fallah, Aria, Lewis, Evan, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Harris, William B, Chen, Jia-Shu, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy W R, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Champagne, Pierre-Olivier, Brunette-Clément, Tristan, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al-Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, and Weil, Alexander G

Abstract

This study was undertaken to determine whether the vertical parasagittal approach or the lateral peri-insular/peri-Sylvian approach to hemispheric surgery is the superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of the HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort study that identified predictors of seizure freedom through logistic regression modeling. Only patients undergoing vertical parasagittal, lateral peri-insular/peri-Sylvian, or lateral trans-Sylvian hemispherotomy were included in this post hoc analysis. Differences in seizure freedom rates were assessed using a time-to-event method and calculated using the Kaplan-Meier survival method. Data for 672 participants across 23 centers were collected on the specific hemispherotomy approach. Of these, 72 (10.7%) underwent vertical parasagittal hemispherotomy and 600 (89.3%) underwent lateral peri-insular/peri-Sylvian or trans-Sylvian hemispherotomy. Seizure freedom was obtained in 62.4% (95% confidence interval [CI] = 53.5%-70.2%) of the entire cohort at 10-year follow-up. Seizure freedom was 88.8% (95% CI = 78.9%-94.3%) at 1-year follow-up and persisted at 85.5% (95% CI = 74.7%-92.0%) across 5- and 10-year follow-up in the vertical subgroup. In contrast, seizure freedom decreased from 89.2% (95% CI = 86.3%-91.5%) at 1-year to 72.1% (95% CI = 66.9%-76.7%) at 5-year to 57.2% (95% CI = 46.6%-66.4%) at 10-year follow-up for the lateral subgroup. Log-rank test found that vertical hemispherotomy was associated with durable seizure-free progression compared to the lateral approach (p = .01). Patients undergoing the lateral hemispherotomy technique had a shorter time-to-seizure recurrence (hazard ratio = 2.56, 95% CI = 1.08-6.04, p = .03) and increased seizure recurrence odds (odds ratio = 3.67, 95% CI = 1.05-12.86, p = .04) compared to those undergoing the vertical hemispherotomy technique. This pilot stud

Published
2021

43. Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, Weil, Alexander G, Lewis, Evan C, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Zhou, Xinkai, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Ojemann, Jeffrey, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connelly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Olivier Champagne, Pierre, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, Fallah, Aria, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, Weil, Alexander G, Lewis, Evan C, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Zhou, Xinkai, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Ojemann, Jeffrey, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connelly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Olivier Champagne, Pierre, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, and Fallah, Aria

Abstract

To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug-resistant epilepsy. We analyzed 1267 hemispheric surgeries performed in pediatric participants across 32 centers and 12 countries to identify predictors of seizure freedom at 3 months after surgery. A multivariate logistic regression model was developed based on 70% of the dataset (training set) and validated on 30% of the dataset (validation set). Missing data were handled using multiple imputation techniques. Overall, 817 of 1237 (66%) hemispheric surgeries led to seizure freedom (median follow-up = 24 months), and 1050 of 1237 (85%) were seizure-free at 12 months after surgery. A simple regression model containing age at seizure onset, presence of generalized seizure semiology, presence of contralateral 18-fluoro-2-deoxyglucose-positron emission tomography hypometabolism, etiologic substrate, and previous nonhemispheric resective surgery is predictive of seizure freedom (area under the curve = .72). A Hemispheric Surgery Outcome Prediction Scale (HOPS) score was devised that can be used to predict seizure freedom. Children most likely to benefit from hemispheric surgery can be selected and counseled through the implementation of a scale derived from a multiple regression model. Importantly, children who are unlikely to experience seizure control can be spared from the complications and deficits associated with this surgery. The HOPS score is likely to help physicians in clinical decision-making.

Published
2021

44. Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool

Author

Weil, Alexander G., primary, Lewis, Evan C., additional, Ibrahim, George M., additional, Kola, Olivia, additional, Tseng, Chi‐Hong, additional, Zhou, Xinkai, additional, Lin, Kao‐Min, additional, Cai, Li‐Xin, additional, Liu, Qing‐Zhu, additional, Lin, Jiu‐Luan, additional, Zhou, Wen‐Jing, additional, Mathern, Gary W., additional, Smyth, Matthew D., additional, O'Neill, Brent R., additional, Dudley, Roy, additional, Ragheb, John, additional, Bhatia, Sanjiv, additional, Delev, Daniel, additional, Ramantani, Georgia, additional, Zentner, Josef, additional, Ojemann, Jeffrey, additional, Wang, Anthony C., additional, Dorfer, Christian, additional, Feucht, Martha, additional, Czech, Thomas, additional, Bollo, Robert J., additional, Issabekov, Galymzhan, additional, Zhu, Hongwei, additional, Connelly, Mary, additional, Steinbok, Paul, additional, Zhang, Jian‐Guo, additional, Zhang, Kai, additional, Hidalgo, Eveline Teresa, additional, Weiner, Howard L., additional, Wong‐Kisiel, Lily, additional, Lapalme‐Remis, Samuel, additional, Tripathi, Manjari, additional, Sarat Chandra, Poodipedi, additional, Hader, Walter, additional, Wang, Feng‐Peng, additional, Yao, Yi, additional, Olivier Champagne, Pierre, additional, Guo, Qiang, additional, Li, Shao‐Chun, additional, Budke, Marcelo, additional, Pérez‐Jiménez, Maria Angeles, additional, Raftapoulos, Christian, additional, Finet, Patrice, additional, Michel, Pauline, additional, Schaller, Karl, additional, Stienen, Martin N., additional, Baro, Valentina, additional, Cantillano Malone, Christian, additional, Pociecha, Juan, additional, Chamorro, Noelia, additional, Muro, Valeria L., additional, Lehe, Marec, additional, Vieker, Silvia, additional, Oluigbo, Chima, additional, Gaillard, William D., additional, Al Khateeb, Mashael, additional, Al Otaibi, Faisal, additional, Krayenbühl, Niklaus, additional, Bolton, Jeffrey, additional, Pearl, Phillip L., additional, and Fallah, Aria, additional

Published
2021
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47. Surgical evaluation in children <3 years of age with drug‐resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays.

Author

Perry, Michael Scott, Shandley, Sabrina, Perelman, Max, Singh, Rani K., Wong‐Kisiel, Lily, Sullivan, Joseph, Gonzalez‐Giraldo, Ernesto, Romanowski, Erin Fedak, McNamara, Nancy A., Marashly, Ahmad, Ostendorf, Adam P., Alexander, Allyson, Eschbach, Krista, Bolton, Jeffrey, Wolf, Steven, McGoldrick, Patricia, Depositario‐Cabacar, Dewi F., Ciliberto, Michael A., Gedela, Satyanarayana, and Sannagowdara, Kumar

Subjects
PEDIATRIC surgery, PEOPLE with epilepsy, TREATMENT delay (Medicine), EPILEPSY surgery, SURGICAL excision, PARTIAL epilepsy
Abstract

Objective: Drug‐resistant epilepsy (DRE) occurs at higher rates in children <3 years old. Epilepsy surgery is effective, but rarely utilized in young children despite developmental benefits of early seizure freedom. The present study aims to identify unique patient characteristics and evaluation strategies in children <3 years old who undergo epilepsy surgery evaluation as a means to assess contributors and potential solutions to health care disparities in this group. Methods: The Pediatric Epilepsy Research Consortium Epilepsy Surgery Database, a multicentered, cross‐sectional collaboration of 21 US pediatric epilepsy centers, collects prospective data on children <18 years of age referred for epilepsy surgery evaluation. We compared patient characteristics, diagnostic utilization, and surgical treatment between children <3 years old and those older undergoing initial presurgical evaluation. We evaluated patient characteristics leading to delayed referral (>1 year) after DRE diagnosis in the very young. Results: The cohort included 437 children, of whom 71 (16%) were <3 years of age at referral. Children evaluated before the age of 3 years more commonly had abnormal neurological examinations (p =.002) and daily seizures (p =.001). At least one ancillary test was used in 44% of evaluations. Fifty‐nine percent were seizure‐free following surgery (n = 34), with 35% undergoing limited focal resections. Children with delayed referrals more often had focal aware (p <.001) seizures and recommendation for palliative surgeries (p <.001). Significance: There are relatively few studies of epilepsy surgery in the very young. Surgery is effective, but may be disproportionally offered to those with severe presentations. Relatively low utilization of ancillary testing may contribute to reduced surgical therapy for those without evident lesions on magnetic resonance imaging. Despite this, a sizeable portion of patients have favorable outcome after focal epilepsy surgery resections. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Hemispheric Surgery Outcome Prediction Scale: Development and Validation of a Seizure Freedom Prediction Tool

Author

Fallah, Aria, primary, Weil, Alexander G., additional, Lewis, Evan C., additional, Ibrahim, George M., additional, Kola, Olivia, additional, Tseng, Chi-Hong, additional, Zhou, Xinkai, additional, Lin, Kao-Min, additional, Cai, Li-Xin, additional, Liu, Qing-Zhu, additional, Lin, Jiu-Luan, additional, Zhou, Wen-Jing, additional, Mathern, Gary W., additional, Smyth, Matthew D., additional, O'Neill, Brent R., additional, Dudley, Roy, additional, Ragheb, John, additional, Bhatia, Sanjiv, additional, Delev, Daniel, additional, Ramantani, Georgia, additional, Zentner, Josef, additional, Ojemann, Jeffrey G., additional, Wang, Anthony C., additional, Dorfer, Christian, additional, Feucht, Martha, additional, Czech, Thomas, additional, Bollo, Robert J., additional, Issabekov, Galymzhan, additional, Zhu, Hongwei, additional, Connelly, Mary, additional, Steinbok, Paul, additional, Zhang, Jian-Guo, additional, Zhang, Kai, additional, Hidalgo, Eveline Teresa, additional, Weiner, Howard L., additional, Wong-Kisiel, Lily, additional, Lapalme-Remis, Samuel, additional, Tripathi, Manjari, additional, Chandra, P. Sarat, additional, Hader, Walter, additional, Wang, Feng-Peng, additional, Yao, Yi, additional, Champagne, Pierre Olivier, additional, Guo, Qiang, additional, Li, Shao-Chun, additional, Budke, Marcelo, additional, Pérez-Jiménez, Maria Angeles, additional, Raftapoulos, Christian, additional, Finet, Patrice, additional, Michel, Pauline, additional, Schaller, Karl, additional, Stienen, Martin N., additional, Baro, Valentina, additional, Malone, Christian Cantillano, additional, Pociecha, Juan, additional, Chamorro, Noelia, additional, Muro, Valeria L., additional, von Lehe, Marec, additional, Vieker, Silvia, additional, Oluigbo, Chima, additional, Gaillard, William D., additional, Khateeb, Mashael Al, additional, Otaibi, Faisal Al, additional, Krayenbühl, Niklaus, additional, Bolton, Jeffrey, additional, and Pearl, Phillip L., additional

Published
2020
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