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31 results on '"Bolland, Daniel J."'

1. Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes

Author

Mielczarek, Olga, Rogers, Carolyn H., Zhan, Yinxiu, Matheson, Louise S., Stubbington, Michael J.T., Schoenfelder, Stefan, Bolland, Daniel J., Javierre, Biola M., Wingett, Steven W., Várnai, Csilla, Segonds-Pichon, Anne, Conn, Simon J., Krueger, Felix, Andrews, Simon, Fraser, Peter, Giorgetti, Luca, and Corcoran, Anne E.

Published
2023
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5. Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

Author

Koohy, Hashem, Bolland, Daniel J., Matheson, Louise S., Schoenfelder, Stefan, Stellato, Claudia, Dimond, Andrew, Várnai, Csilla, Chovanec, Peter, Chessa, Tamara, Denizot, Jeremy, Manzano Garcia, Raquel, Wingett, Steven W., Freire-Pritchett, Paula, Nagano, Takashi, Hawkins, Phillip, Stephens, Len, Elderkin, Sarah, Spivakov, Mikhail, Fraser, Peter, Corcoran, Anne E., and Varga-Weisz, Patrick D.

Published
2018
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14. The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

Author

Hill, Danika L., primary, Pierson, Wim, additional, Bolland, Daniel J., additional, Mkindi, Catherine, additional, Carr, Edward J., additional, Wang, Jiong, additional, Houard, Sophie, additional, Wingett, Steven W., additional, Audran, Regine, additional, Wallin, Elizabeth F., additional, Jongo, Said A., additional, Kamaka, Kassim, additional, Zand, Martin, additional, Spertini, Francois, additional, Daubenberger, Claudia, additional, Corcoran, Anne E., additional, and Linterman, Michelle A., additional

Published
2019
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18. Intra- and interchromosomal contact mapping reveals the Ighlocus has extensive conformational heterogeneity and interacts with B-lineage genes

Author

Mielczarek, Olga, Rogers, Carolyn H., Zhan, Yinxiu, Matheson, Louise S., Stubbington, Michael J.T., Schoenfelder, Stefan, Bolland, Daniel J., Javierre, Biola M., Wingett, Steven W., Várnai, Csilla, Segonds-Pichon, Anne, Conn, Simon J., Krueger, Felix, Andrews, Simon, Fraser, Peter, Giorgetti, Luca, and Corcoran, Anne E.

Abstract

To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (VH), diversity (DH), and joining (JH) genes. These chromosomal alterations are poorly understood. Uncovering their patterns shows how chromosome dynamics underpins antibody diversity. Using tiled Capture Hi-C, we produce a comprehensive map of chromatin interactions throughout the 2.8-Mb Ighlocus in progenitor B cells. We find that the Ighlocus folds into semi-rigid subdomains and undergoes flexible looping of the VHgenes to its 3′ end, reconciling two views of locus organization. Deconvolution of single Ighlocus conformations using polymer simulations identifies thousands of different structures. This heterogeneity may underpin the diversity of V(D)J recombination events. All three immunoglobulin loci also participate in a highly specific, developmentally regulated network of interchromosomal interactions with genes encoding B cell-lineage factors. This suggests a model of interchromosomal coordination of B cell development.

Published
2023
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21. Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice

Author

Zou, Xiangang, primary, Osborn, Michael J., additional, Bolland, Daniel J., additional, Smith, Jennifer A., additional, Corcos, Daniel, additional, Hamon, Maureen, additional, Oxley, David, additional, Hutchings, Amanda, additional, Morgan, Geoff, additional, Santos, Fatima, additional, Kilshaw, Peter J., additional, Taussig, Michael J., additional, Corcoran, Anne E., additional, and Brüggemann, Marianne, additional

Published
2007
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28. Genomic analysis of facioscapulohumeral muscular dystrophy.

Author

Clapp, Jannine, Bolland, Daniel J., and Hewitt, Jane E.

Subjects
*GENOMICS, *MOLECULAR genetics, *MUSCULAR dystrophy, *NEUROMUSCULAR diseases, *GENETICS
Abstract

The genomic basis of facioscapulohumeral muscular dystrophy (FSHD) is of considerable interest because of the unique nature of the molecular mutation, which is a deletion within a large, complex DNA tandem array (D4Z4). This repeat maps within 30 kb of the 4q telomere. Although D4Z4 repeat units each contain an open reading frame that could encode a homeodomain protein, there is no evidence that the repeat is transcribed, and the underlying disease mechanism probably involves a position effect. A recent study has identified a protein complex bound to D4Z4 that contains YY1 and HMGB2, implicating a role for D4Z4 as a repressor. The 4q telomere has two variants, 4qA and 4qB. Although these alleles are present at almost equal frequencies in the general population, FSHD is associated only with the 4qA allele and never with 4qB. This suggests a functional difference between the telomere variants, either in predisposition to deletions within D4Z4 or in the pathological consequence of the deletion. Comparative mapping studies of the FSHD region in primates, mouse and Fugu rubripes have given insights into the evolutionary history of the D4Z4 repeat and of 4qter, although as yet they have not provided any solutions to the FSHD puzzle. [ABSTRACT FROM AUTHOR]

Published
2003
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29. IL-7R signaling activates widespread VHand DHgene usage to drive antibody diversity in bone marrow B cells

Author

Baizan-Edge, Amanda, Stubbs, Bryony A., Stubbington, Michael J.T., Bolland, Daniel J., Tabbada, Kristina, Andrews, Simon, and Corcoran, Anne E.

Abstract

Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. The role of interleukin-7 receptor (IL-7R) signaling in Ighrecombination has been difficult to partition from its role in B cell survival and proliferation. With a detailed description of the Ighrepertoire in murine IL-7Rα−/−bone marrow B cells, we demonstrate that IL-7R signaling profoundly influences VHgene selection during VH-to-DJHrecombination. We find skewing toward 3′ VHgenes during de novoVH-to-DJHrecombination more severe than the fetal liver (FL) repertoire and uncover a role for IL-7R signaling in DH-to-JHrecombination. Transcriptome and accessibility analyses suggest reduced expression of B lineage transcription factors (TFs) and targets and loss of DHand VHantisense transcription in IL-7Rα−/−B cells. Thus, in addition to its roles in survival and proliferation, IL-7R signaling shapes the Ighrepertoire by activating underpinning mechanisms.

Published
2021
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31. The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

Author

Hill, Danika L, Pierson, Wim, Bolland, Daniel J, Mkindi, Catherine, Carr, Edward J, Wang, Jiong, Houard, Sophie, Wingett, Steven W, Audran, Regine, Wallin, Elizabeth F, Jongo, Said A, Kamaka, Kassim, Zand, Martin, Spertini, Francois, Daubenberger, Claudia, Corcoran, Anne E, and Linterman, Michelle A

Subjects
Adult, Male, Adolescent, Drug Compounding, Receptors, Antigen, T-Cell, alpha-beta, Plasmodium falciparum, Aluminum Hydroxide, Antigens, Protozoan, Antibodies, Viral, Young Adult, Adjuvants, Immunologic, Glucosides, Malaria Vaccines, Humans, Cells, Cultured, Aged, Aged, 80 and over, B-Lymphocytes, Vaccination, T-Lymphocytes, Helper-Inducer, Middle Aged, Germinal Center, 3. Good health, Immunity, Humoral, Lipid A, Influenza Vaccines, Female, Lymph Nodes
Abstract

The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite the central role of Tfh cells in vaccine responses, there is currently no validated way to enhance their differentiation in humans. From paired human lymph node and blood samples, we identify a population of circulating Tfh cells that are transcriptionally and clonally similar to germinal center Tfh cells. In a clinical trial of vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an experimental malaria vaccine was adjuvanted in GLA-SE but not when formulated in Alum. The GLA-SE–formulated peptide was associated with an increase in the extrafollicular antibody response, long-lived antibody production, and the emergence of public TCRβ clonotypes in circulating Tfh cells. We demonstrate that altering vaccine adjuvants is a rational approach for enhancing Tfh cells in humans, thereby supporting the long-lived humoral immunity that is required for effective vaccines.

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