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1. Disorders of Sexual Development in Newborns

Author

Balsamo, Antonio, Ghirri, Paolo, Bertelloni, Silvano, Scaramuzzo, Rosa T., D’Alberton, Franco, Cicognani, Alessandro, Boldrini, Antonio, Buonocore, Giuseppe, editor, Bracci, Rodolfo, editor, and Weindling, Michael, editor

Published
2018
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3. Disorders of Sexual Development in Newborns

Author

Balsamo, Antonio, primary, Ghirri, Paolo, additional, Bertelloni, Silvano, additional, Scaramuzzo, Rosa T., additional, D’Alberton, Franco, additional, Cicognani, Alessandro, additional, and Boldrini, Antonio, additional

Published
2017
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4. Disorders of Sexual Development

Author

Balsamo, Antonio, Cicognani, Alessandro, Ghirri, Paolo, Scaramuzzo, Rosa T., D’Alberton, Franco, Bertelloni, Silvano, Boldrini, Antonio, Buonocore, Giuseppe, editor, Bracci, Rodolfo, editor, and Weindling, Michael, editor

Published
2012
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5. Endocrine Diseases of Newborn

Author

Ghirri, Paolo, Balsamo, Antonio, Ciantelli, Massimiliano, Boldrini, Antonio, Cicognani, Alessandro, Buonocore, Giuseppe, editor, Bracci, Rodolfo, editor, and Weindling, Michael, editor

Published
2012
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6. Area‐based study identifies risk factors associated with missed antenatal corticosteroid prophylaxis in women delivering preterm infants

Author

Gagliardi, Luigi, Amador, Carolina, Puglia, Monia, Mecacci, Federico, Pratesi, Simone, Sigali, Emilio, Tomasini, Barbara, Rusconi, Franca, Banchini, Roberto, Papi, Maria Celeste, Pecori, Debora, Dani, Carlo, Ingargiola, Anna, Moroni, Marco, Fiorini, Patrizio, Vuerich, Marco, Santarlasci, Sara, Boldrini, Antonio, Dilucia, Sofia, Panariello, Giorgio, Vinciguerra, Filomena, Giovannoni, Armando, Dolfi, Pina, Moschetti, Riccardo, Tognetti, Simona, Capuzzo, Leila, Magnanensi, Stefania, Mariotti, Paola, Brioschi, Alessandra, Martelli, Elena, Vasarri, Pier Luigi, Carlotti, Carla, Danieli, Roberto, Gragnani, Samuele, Benetti, Gian Luca, Tiezzi, Monica, Civitelli, Flavio, Magi, Letizia, Martini, Marco, Cardinale, Antonio, Magni, Carla, Bini, Rita, De Filippo, Marcello, Cafaggi, Leonardo, Bosi, Cristiana, Gambi, Beatrice, Pezzati, Marco, Strano, Massimo, Bartoli, Ambra, Gabrielli, Paolo, Verucci, Elena, Berni, Roberto, Corsi, Andrea, and Voller, Fabio

Published
2017
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8. Disorders of Sexual Development in Newborns

Author

Balsamo, Antonio, primary, Ghirri, Paolo, additional, Bertelloni, Silvano, additional, Scaramuzzo, Rosa T., additional, D’Alberton, Franco, additional, Cicognani, Alessandro, additional, and Boldrini, Antonio, additional

Published
2016
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19. Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)

Author

Filippi Luca, Fiorini Patrizio, Daniotti Marta, Catarzi Serena, Savelli Sara, Fonda Claudio, Bartalena Laura, Boldrini Antonio, Giampietri Matteo, Scaramuzzo Rosa, Papoff Paola, Del Balzo Francesca, Spalice Alberto, la Marca Giancarlo, Malvagia Sabrina, Della Bona Maria, Donzelli Gianpaolo, Tinelli Francesca, Cioni Giovanni, Pisano Tiziana, Falchi Melania, and Guerrini Renzo

Subjects
Neonatal hypoxic-ischemic encephalopathy, Therapeutic hypothermia, Topiramate, Pediatrics, RJ1-570
Abstract

Abstract Background Despite progresses in neonatal care, the mortality and the incidence of neuro-motor disability after perinatal asphyxia have failed to show substantial improvements. In countries with a high level of perinatal care, the incidence of asphyxia responsible for moderate or severe encephalopathy is still 2–3 per 1000 term newborns. Recent trials have demonstrated that moderate hypothermia, started within 6 hours after birth and protracted for 72 hours, can significantly improve survival and reduce neurologic impairment in neonates with hypoxic-ischemic encephalopathy. It is not currently known whether neuroprotective drugs can further improve the beneficial effects of hypothermia. Topiramate has been proven to reduce brain injury in animal models of neonatal hypoxic ischemic encephalopathy. However, the association of mild hypothermia and topiramate treatment has never been studied in human newborns. The objective of this research project is to evaluate, through a multicenter randomized controlled trial, whether the efficacy of moderate hypothermia can be increased by concomitant topiramate treatment. Methods/Design Term newborns (gestational age ≥ 36 weeks and birth weight ≥ 1800 g) with precocious metabolic, clinical and electroencephalographic (EEG) signs of hypoxic-ischemic encephalopathy will be randomized, according to their EEG pattern, to receive topiramate added to standard treatment with moderate hypothermia or standard treatment alone. Topiramate will be administered at 10 mg/kg once a day for the first 3 days of life. Topiramate concentrations will be measured on serial dried blood spots. 64 participants will be recruited in the study. To evaluate the safety of topiramate administration, cardiac and respiratory parameters will be continuously monitored. Blood samplings will be performed to check renal, liver and metabolic balance. To evaluate the efficacy of topiramate, the neurologic outcome of enrolled newborns will be evaluated by serial neurologic and neuroradiologic examinations. Visual function will be evaluated by means of behavioural standardized tests. Discussion This pilot study will explore the possible therapeutic role of topiramate in combination with moderate hypothermia. Any favourable results of this research might open new perspectives about the reduction of cerebral damage in asphyxiated newborns. Trial registration Current Controlled Trials ISRCTN62175998; ClinicalTrials.gov Identifier NCT01241019; EudraCT Number 2010-018627-25

Published
2012
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21. Additional file 3: Table S3. of Technical realization of a sensorized neonatal intubation skill trainer for operatorsâ retraining and a pilot study for its validation

Author

Panizza, Davide, Scaramuzzo, Rosa, Moscuzza, Francesca, Vannozzi, Ilaria, Ciantelli, Massimiliano, Gentile, Marzia, Baldoli, Ilaria, Tognarelli, Selene, Boldrini, Antonio, and Cuttano, Armando

Abstract

Mean pressure values scheduled for attempts in two session. We considered data with outliers exclusion. (DOCX 13Â kb)

Published
2018
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22. Additional file 2: Table S2. of Technical realization of a sensorized neonatal intubation skill trainer for operatorsâ retraining and a pilot study for its validation

Author

Panizza, Davide, Scaramuzzo, Rosa, Moscuzza, Francesca, Vannozzi, Ilaria, Ciantelli, Massimiliano, Gentile, Marzia, Baldoli, Ilaria, Tognarelli, Selene, Boldrini, Antonio, and Cuttano, Armando

Abstract

Mean times of operators scheduled for attempts in two session. (DOCX 12Â kb)

Published
2018
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24. Universal neonatal audiological screening: experience of the University Hospital of Pisa

Author

Baggiani Angelo, Boldrini Antonio, Forli Francesca, Lunardi Sara, Liumbruno Annalisa, Ghirri Paolo, and Berrettini Stefano

Subjects
Pediatrics, RJ1-570
Abstract

Abstract The early identification of pre-lingual deafness is necessary to minimize the consequences of hearing impairment on the future communication skills of a baby. According to the most recent international guidelines the deafness diagnosis must occur before the age of three months and the prosthetic-rehabilitative treatment with a traditional hearing aid should start within the first six months. When a Cochlear implant becomes necessary, the treatment should start between the age of 12 months and 18 months. The only way to diagnose the problem early is the implementation of universal neonatal audiological screening programs. Transient evoked otoacoustic emissions (TEOAE) is the most adequate test because it's accurate, economic and of simple execution. Automatic auditory brainstem response (AABR) is necessary to identify patients with auditory neuropathy but it is also important to reduce the number of false-positives.The 20-30% of infant hearing impairment is represented by progressive or late-onset hearing loss (HL) so it's also necessary to establish an audiological follow up program, especially in infants at risk. From November 2005 all neonates born in the University hospital of Pisa undergo newborn hearing screening. From 2008 the screening program follows the guidelines for the execution of the audiological screening in Tuscany which have been formulated by our group according to the 2007 JCIH Position Statement and adaptated to our regional reality by a multidisciplinary effort. From November 2005 to April 2009 8113 neonates born in the Neonatal Unit of Santa Chiara Hospital (Pisa) have undergone newborn hearing screening. 7621 neonates (93.9%) without risk factors executed only the TEOAE test. 492 (6.1%) neonates had audiological risk factors and thus underwent TEOAE and AABR. 84 patients (1,04%) failed both TEOAE and AABR tests. 78 of them underwent further investigations. 44 patients resulted falsepositives (the 0,54% of the screened newborns). 34 neonates (4,2 ‰) had a final diagnosis of hearing impairment. 8 patients (0.99 ‰) had unilateral hearing loss (HL). 26 patients (3,2 ‰) had bilateral hearing impairment. In our screening program the percentage of false-positives was quite low (0.54%) while the incidence of bilateral HL (3.2 ‰) is a little higher than that found in literature reports. In most of our patients premature birth or neonatal suffering represent the main cause of HL.

Published
2011
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25. Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study

Author

Magnani Cinzia, Gragnani Giuseppe S, Giuffrè Mario, Gerola Orietta, Di Stefano Maria C, De Santis Luisa, Danieli Roberto, Cocchi Guido, Celandroni Amerigo, Pardi Daniela, Bertelloni Silvano, Scaramuzzo Rosa T, Ghirri Paolo, Meossi Cristiano, Merusi Ilaria, Sabatino Giuseppe, Tumini Stefano, Corsello Giovanni, and Boldrini Antonio

Subjects
Pediatrics, RJ1-570
Abstract

Abstract Background Hypospadias is a congenital displacement of the urethral meatus in male newborns, being either an isolated defect at birth or a sign of sexual development disorders. The aim of this study was to assess the prevalence rate of hypospadias in different Districts of Italy, in order to make a comparison with other countries all over the world. Methods We reviewed all the newborns file records (years 2001–2004) in 15 Italian Hospitals. Results We found an overall hypospadias prevalence rate of 3.066 ± 0.99 per 1000 live births (82.48% mild hypospadias, 17.52% moderate-severe). In newborns Small for Gestational Age (birthweight < 10th percentile) of any gestational age the prevalence rate of hypospadias was 6.25 per 1000 live births. Performing multivariate logistic regression analysis for different degrees of hypospadias according to severity, being born SGA remained the only risk factor for moderate-severe hypospadias (p = 0.00898) but not for mild forms (p > 0.1). Conclusion In our sample the prevalence of hypospadias results as high as reported in previous European and American studies (3–4 per 1000 live births). Pathogenesis of isolated hypospadias is multifactorial (genetic, endocrine and environmental factors): however, the prevalence rate of hypospadias is higher in infants born small for gestational age than in newborns with normal birth weight.

Published
2009
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26. Raccomandazioni sulla Profilassi dell’infezione da Virus Respiratorio Sinciziale (VRS) con il Palivizumab

Author

Bollani, Lina, Baraldi, Eugenio, Chirico, Gaetano, Dotta, Andrea, Vecchio, Antonello Del, Manzoni, Paolo, Boldrini, Antonio, Paolillo, Piermichele, Fabio, Sandra Di, Orfeo, Luigi, Stronati, Mauro, Romagnoli, Costantino, LANARI, MARCELLO, Bollani, Lina, Baraldi, Eugenio, Chirico, Gaetano, Dotta, Andrea, Lanari, Marcello, Vecchio, Antonello Del, Manzoni, Paolo, Boldrini, Antonio, Paolillo, Piermichele, Fabio, Sandra Di, Orfeo, Luigi, Stronati, Mauro, and Romagnoli, Costantino

Subjects
Virus Respiratorio Sinciziale
Abstract

L’infezione da Virus Respiratorio Sinciziale (VRS) rappresenta ancora oggi una delle più frequenti cause di ricovero in reparti pediatrici, intensivi e non, ed è anche gravata da mortalità, specialmente nelle popolazioni più fragili. La terapia è solo sintomatica e di supporto e solo la profilassi può avere un ruolo nella riduzione della frequenza della malattia e delle sue conseguenze. Dopo molti anni, grazie anche alla mole di studi pubblicati in proposito, la Società Italiana di Neonatologia (SIN) ha sentito il bisogno di elaborare le nuove Raccomandazioni della Società sulla profilassi della infezione da VRS. La SIN ha nominato a questo scopo una Task force che ha proposto al Direttivo un elaborato che, integrato con quanto riportato nel documento inter-societario recentemente pubblicato, costituisce il documento che viene proposto per agevolare scelte non sempre facili. Le Raccomandazioni sono state elaborate sulla base delle più recenti evidenze scientifiche ed hanno lo scopo di fornire ai neonatologi e ai pediatri una guida operativa pratica. Pur consapevole che problemi economici potrebbero interferire con queste Raccomandazioni, la SIN ha anche inteso non considerare nel documento gli aspetti economici in quanto questi vanno al di là delle competenze di una società scientifica. Un grazie di cuore a tutti coloro che hanno collaborato alla loro realizzazione ed anche a coloro che con il loro operato potranno fornire utili indicazioni per future modifiche migliorative.

Published
2015

27. Technical realization of a sensorized neonatal intubation skill trainer for operators’ retraining and a pilot study for its validation

Author

Panizza, Davide, primary, Scaramuzzo, Rosa T., additional, Moscuzza, Francesca, additional, Vannozzi, Ilaria, additional, Ciantelli, Massimiliano, additional, Gentile, Marzia, additional, Baldoli, Ilaria, additional, Tognarelli, Selene, additional, Boldrini, Antonio, additional, and Cuttano, Armando, additional

Published
2018
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28. Association of maternal hypertension and chorioamnionitis with preterm outcomes

Author

Gagliardi, Luigi, Rusconi, Franca, Bellù, Roberto, Zanini, Rinaldo, Mirri, Gianpaolo, Condò, Manuela, Turoli, Daniela, Vanzati, Mara, Mosca, Fabio, De Nisi, Giuseppe, Polacco, Paola, Villa, Elena, Barbarini, Mario, Fasolato, Valeria, Franco, Caterina, Contiero, Raffaella, Ellero, Serena, Cattarossi, Luigi, Abbiati, Laura, Borroni, Cesarina, Prandi, Giovanna, Fabris, Claudio, Vielmi, Francesca, Borgione, Silvia, Agosti, Massimo, Tandoi, Francesco, Guidali, Rosanna, De Curtis, Mario, Tozzi, Claudio, Lucchini, Renato, Battaglioli, Marina, Lista, Gian Luca, Introvini, Paola, Ferrari, Fabrizio, Gallo, Claudio, Bellante, Elvira, Bottura, Chiara, Zeringyte, Aurelija, Pasquali, Francesca, Boccacci, Simona, Latini, Giuseppe, Giannuzzi, Raffaella, Martinelli, Stefano, Brunelli, Alberto, Di Nunzio, Maria Lucia, Vendemmiati, Antonio, Carli, Giovanna, Bordigato, Michela Alfiero, Filippone, Marco, Meneghesso, Davide, Romeo, Nicola, Mammoliti, Palma, Mastretta, Emanuele, Barberis, Laura, Farina, Daniele, Gancia, Gianpaolo, Dalmazzo, Cristina, Napolitano, Marcello, Messina, Francesco, Villa Betania, Napoli, Magaldi, Rosario, Rinaldi, Matteo, Litta, Rosangela, Lago, Paola, Zanardo, Vincenzo, Chiandetti, Lino, Visentin, Stefano, Presta, Giuseppe, Cella, Davide, Poggiani, Carlo, Ferrari, Daniela, Parati, Sara, Lombardo, Francesco, Grigorio, Rosetta, Barera, Graziano, Bove, Maddalena, Poloniato, Antonella, Burgio, Giampiero, Sala, Elena, Barberi, Ignazio, Tiralongo, Venera, Arco, Alessandro, Mazzeo, Danila, Dani, Carlo, Pratesi, Simone, Mignatti, Valeria, Ancora, Gina, Faldella, Giacomo, Grandi, Sara, Locatelli, Chiara, Stronati, Mauro, Perotti, Gianfranco, Chirico, Gaetano, Migliori, Claudio, De Marini, Sergio, Forleo, Vincenzo, Paludetto, Roberto, Capasso, Letizia, Mansi, Giuseppina, Raimondi, Francesco, Bona, Gianni, Stucchi, Ilaria, Savastio, Silvia, Ferrero, Federica, Parola, Andrea, Padovani, Ezio Maria, Viviani, Elena, Pecoraro, Laura, Agostino, Rocco, Gizzi, Camilla, Massenzi, Luca, Messner, Hubert, Staffler, Alex, Salvia, Gennaro, Esposito, Luigi, Forziati, Vincenzo, Latorre, Giuseppe, Sandri, Fabrizio, Alati, Stefania, Demarca, Fabrizio, Lombardi, Oreste, Costabile, Carmine Deni, Scarpelli, Gianfranco, Cavalli, Claudio, Volante, Enrico, Moretti, Sabrina, Ganguzza, Olga, Spinella, Bartolomeo, Haass, Cristina, Scapillati, Eleonora, Consigli, Chiara, Gatta, Alberto, Quitadamo, Pasqua, Boldrini, Antonio, Vuerich, Marco, Sigali, Emilio, Fiorini, Patrizio, Petrucci, Letizia, Moroni, Marco, Meyer, Firenze, Bragetti, Patrizia, Casucci, Paola, Minelli, Liliana, Mezzetti, Daniele, Orfeo, Luigi, De Luca, Maria Gabriella, Laforgia, Nicola, Grassi, Alessandro, Dotta, Andrea, Savignoni, Ferdinando, Bagnoli, Franco, De Felice, Claudio, Badii, Silvia, Biasini, Augusto, Belluzzi, Antonio, Stella, Marcello, Romagnoli, Costantino, Zecca, Enrico, Barone, Giovanni, Colleselli, Paolo, Vecchiato, Luca, Nicolussi, Silvia, Giliberti, Paolo, Chello, Giovanni, Rojo, Silvana, De Vivo, Massimiliano, Giovanettoni, Chiara, Colnaghi, Clelia A., Manfredini, Valeria, Verucci, Elena, Placidi, Giulia, Belloni, Cesare, Carrera, Giuseppe, Zambetti, Chiara, Biban, Paolo, Serra, Alessandra, Sacco, Francesco, Vetrano, Gennaro, Furcolo, Giuseppe, Pasquariello, Brigida, Falco, Luigi, Ausanio, Gaetano, Bernardo, Italo, Capasso, Antonella, Marchesano, Giuseppe, Nosari, Norberto, Sarnelli, Paola, Ciraci, Giovanni, Merazzi, Daniele, Gazzolo, Diego, Temperini, Francesca, Sabatini, Miriam, Colivicchi, Micaela, Del Vecchio, Antonio, Tarantino, Marzia, Gargano, Giancarlo, Pedori, Simona, Bellettato, Massimo, Pesavento, Roberta, Cesaro, Alessandra, Scollo, Massimo, Mondello, Isabella, Pugliese, Aniello, Iervolino, Claudio, Corsello, Giovanni, Giuffré, Mario, Betta, Pasqua, Romeo, Mario Giuseppe, Saporito, Alessandro, Leone, Maria Grazia, Rodonò, Alessandro, Franceschi, Alessia, Risso, Francesco M., Carpentieri, Mauro, Vecchiano, Teresa, Cigliano, Maria Pia, Paolillo, Piermichele, Picone, Simonetta, Marra, Antonio, Rossetti, Gessica, Testa, Tiziana, Del Cuore, Fernando, Crescenzi, Francesco, Poloni, Gianna, Russo, Maria Chiara, Nigro, Francesco, Tina, Gabriella Lucia, Brindisino, Patrizia, Gurrado, Raffaele, Felice, Maurizio, Formica, Isabella, Gagliardi, L, Rusconi, F, Bellu, R, Zanini, R, Corsello, G, Giuffre, M, Italian Neonatal Network, Luigi Gagliardi, Franca Rusconi, Roberto Bellù, Rinaldo Zanini, the Italian Neonatal Network [.., Gina Ancora, Giacomo Faldella, Sara Grandi, Chiara Locatelli, ]., Gagliardi, Luigi, Rusconi, Franca, Bellù, Roberto, Zanini, Rinaldo, Mirri, Gianpaolo, Condò, Manuela, Turoli, Daniela, Vanzati, Mara, Mosca, Fabio, De Nisi, Giuseppe, Polacco, Paola, Villa, Elena, Barbarini, Mario, Fasolato, Valeria, Franco, Caterina, Contiero, Raffaella, Ellero, Serena, Cattarossi, Luigi, Abbiati, Laura, Borroni, Cesarina, Prandi, Giovanna, Fabris, Claudio, Vielmi, Francesca, Borgione, Silvia, Agosti, Massimo, Tandoi, Francesco, Guidali, Rosanna, De Curtis, Mario, Tozzi, Claudio, Lucchini, Renato, Battaglioli, Marina, Lista, Gian Luca, Introvini, Paola, Ferrari, Fabrizio, Gallo, Claudio, Bellante, Elvira, Bottura, Chiara, Zeringyte, Aurelija, Pasquali, Francesca, Boccacci, Simona, Latini, Giuseppe, Giannuzzi, Raffaella, Martinelli, Stefano, Brunelli, Alberto, Di Nunzio, Maria Lucia, Vendemmiati, Antonio, Carli, Giovanna, Bordigato, Michela Alfiero, Filippone, Marco, Meneghesso, Davide, Romeo, Nicola, Mammoliti, Palma, Mastretta, Emanuele, Barberis, Laura, Farina, Daniele, Gancia, Gianpaolo, Dalmazzo, Cristina, Napolitano, Marcello, Messina, Francesco, Villa Betania, Napoli, Magaldi, Rosario, Rinaldi, Matteo, Litta, Rosangela, Lago, Paola, Zanardo, Vincenzo, Chiandetti, Lino, Visentin, Stefano, Presta, Giuseppe, Cella, Davide, Poggiani, Carlo, Ferrari, Daniela, Parati, Sara, Lombardo, Francesco, Grigorio, Rosetta, Barera, Graziano, Bove, Maddalena, Poloniato, Antonella, Burgio, Giampiero, Sala, Elena, Barberi, Ignazio, Tiralongo, Venera, Arco, Alessandro, Mazzeo, Danila, Dani, Carlo, Pratesi, Simone, Mignatti, Valeria, Ancora, Gina, Faldella, Giacomo, Grandi, Sara, Locatelli, Chiara, Stronati, Mauro, Perotti, Gianfranco, Chirico, Gaetano, Migliori, Claudio, De Marini, Sergio, Forleo, Vincenzo, Paludetto, Roberto, Capasso, Letizia, Mansi, Giuseppina, Raimondi, Francesco, Bona, Gianni, Stucchi, Ilaria, Savastio, Silvia, Ferrero, Federica, Parola, Andrea, Padovani, Ezio Maria, Viviani, Elena, Pecoraro, Laura, Agostino, Rocco, Gizzi, Camilla, Massenzi, Luca, Messner, Hubert, Staffler, Alex, Salvia, Gennaro, Esposito, Luigi, Forziati, Vincenzo, Latorre, Giuseppe, Sandri, Fabrizio, Alati, Stefania, Demarca, Fabrizio, Lombardi, Oreste, Costabile, Carmine Deni, Scarpelli, Gianfranco, Cavalli, Claudio, Volante, Enrico, Moretti, Sabrina, Ganguzza, Olga, Spinella, Bartolomeo, Haass, Cristina, Scapillati, Eleonora, Consigli, Chiara, Gatta, Alberto, Quitadamo, Pasqua, Boldrini, Antonio, Vuerich, Marco, Sigali, Emilio, Fiorini, Patrizio, Petrucci, Letizia, Moroni, Marco, Meyer, Firenze, Bragetti, Patrizia, Casucci, Paola, Minelli, Liliana, Mezzetti, Daniele, Orfeo, Luigi, De Luca, Maria Gabriella, Laforgia, Nicola, Grassi, Alessandro, Dotta, Andrea, Savignoni, Ferdinando, Bagnoli, Franco, De Felice, Claudio, Badii, Silvia, Biasini, Augusto, Belluzzi, Antonio, Stella, Marcello, Romagnoli, Costantino, Zecca, Enrico, Barone, Giovanni, Colleselli, Paolo, Vecchiato, Luca, Nicolussi, Silvia, Giliberti, Paolo, Chello, Giovanni, Rojo, Silvana, De Vivo, Massimiliano, Giovanettoni, Chiara, Colnaghi, Clelia A., Manfredini, Valeria, Verucci, Elena, Placidi, Giulia, Belloni, Cesare, Carrera, Giuseppe, Zambetti, Chiara, Biban, Paolo, Serra, Alessandra, Sacco, Francesco, Vetrano, Gennaro, Furcolo, Giuseppe, Pasquariello, Brigida, Falco, Luigi, Ausanio, Gaetano, Bernardo, Italo, Capasso, Antonella, Marchesano, Giuseppe, Nosari, Norberto, Sarnelli, Paola, Ciraci, Giovanni, Merazzi, Daniele, Gazzolo, Diego, Temperini, Francesca, Sabatini, Miriam, Colivicchi, Micaela, Del Vecchio, Antonio, Tarantino, Marzia, Gargano, Giancarlo, Pedori, Simona, Bellettato, Massimo, Pesavento, Roberta, Cesaro, Alessandra, Scollo, Massimo, Mondello, Isabella, Pugliese, Aniello, Iervolino, Claudio, Corsello, Giovanni, Giuffré, Mario, Betta, Pasqua, Romeo, Mario Giuseppe, Saporito, Alessandro, Leone, Maria Grazia, Rodonò, Alessandro, Franceschi, Alessia, Risso, Francesco M., Carpentieri, Mauro, Vecchiano, Teresa, Cigliano, Maria Pia, Paolillo, Piermichele, Picone, Simonetta, Marra, Antonio, Rossetti, Gessica, Testa, Tiziana, Del Cuore, Fernando, Crescenzi, Francesco, Poloni, Gianna, Russo, Maria Chiara, Nigro, Francesco, Tina, Gabriella Lucia, Brindisino, Patrizia, Gurrado, Raffaele, Felice, Maurizio, and Formica, Isabella

Subjects
Male, Pediatrics, Logistic models, Mortality, Outcomes, Pregnancy complications, Preterm infants, Risks, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Diseases, Pregnancy, Pregnancy Outcome, Prospective Studies, Chorioamnionitis, Hypertension, Pregnancy-Induced, Pediatrics, Perinatology and Child Health, Medicine (all), Arts and Humanities (miscellaneous), Diseases, outcomes, Maternal hypertension, risk, Obstetrics, pregnancy complications, Gestational age, Retinopathy of prematurity, Perinatology and Child Health, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Logistic models, Mortality, Outcomes, Pregnancy complications, Preterm infants, Risks, Necrotizing enterocolitis, Hypertension, outcome, Human, medicine.medical_specialty, Pregnancy-Induced, preterm infant, Pregnancy complication, medicine, preterm infants, Premature, logistic model, Chorioamnioniti, business.industry, Infant, Infant, Premature, Disease, Odds ratio, medicine.disease, Newborn, mortality, Prospective Studie, Bronchopulmonary dysplasia, business, logistic models, risks
Abstract

OBJECTIVES: We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects. METHODS: A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian Neonatal Network, was analyzed. Infants born from mothers who had hypertensive disorders (N = 2096) were compared with those born after chorioamnionitis (N = 1510). Statistical analysis employed logistic models, adjusting for GA, hospital, and potential confounders. RESULTS: Overall mortality was higher after hypertension than after chorioamnionitis (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.08–1.80), but this relationship changed across GA weeks; the OR for hypertension was highest at low GA, whereas from 28 weeks' GA onward, mortality was higher for chorioamnionitis. For other outcomes, the relative risks were constant across GA; infants born after hypertension had an increased risk for bronchopulmonary dysplasia (OR, 2.20; 95% CI, 1.68–2.88) and severe retinopathy of prematurity (OR, 1.48; 95% CI, 1.02–2.15), whereas there was a lower risk for early-onset sepsis (OR, 0.25; 95% CI, 0.19–0.34), severe intraventricular hemorrhage (OR, 0.65; 95% CI, 0.48–0.88), periventricular leukomalacia (OR, 0.70; 95% CI, 0.48–1.01), and surgical necrotizing enterocolitis or gastrointestinal perforation (OR, 0.47; 95% CI, 0.31–0.72). CONCLUSIONS: Mortality and other adverse outcomes in very preterm infants depend on antecedents of preterm birth. Hypertension and chorioamnionitis are associated with different patterns of outcomes; for mortality, the effect changes across GA weeks.

Published
2014

29. Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI): a feasibility study

Author

Filippi, Luca, primary, Fiorini, Patrizio, additional, Catarzi, Serena, additional, Berti, Elettra, additional, Padrini, Letizia, additional, Landucci, Elisa, additional, Donzelli, Gianpaolo, additional, Bartalena, Laura, additional, Fiorentini, Erika, additional, Boldrini, Antonio, additional, Giampietri, Matteo, additional, Scaramuzzo, Rosa Teresa, additional, la Marca, Giancarlo, additional, Della Bona, Maria Luisa, additional, Fiori, Simona, additional, Tinelli, Francesca, additional, Bancale, Ada, additional, Guzzetta, Andrea, additional, Cioni, Giovanni, additional, Pisano, Tiziana, additional, Falchi, Melania, additional, and Guerrini, Renzo, additional

Published
2017
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32. A novel simulator for mechanical ventilation in newborns: MERESSINA

Author

Baldoli, Ilaria, Armando Cuttano, Scaramuzzo, ROSA TERESA, Tognarelli, Selene, Ciantelli, Massimiliano, Cecchi, Francesca, Gentile, Marzia, Sigali, Emilio, Laschi, Cecilia, Paolo Ghirri, Menciassi, Arianna, Dario, Paolo, and Boldrini, Antonio

Subjects
Medical simulation, training, newborns, mechanical ventilation, Medical simulation, training, newborns, mechanical ventilation
Published
2015

36. Exome sequencing and pathway analysis for identification of genetic variability relevant for bronchopulmonary dysplasia (BPD) in preterm newborns: A pilot study

Author

Carrera, Paola, Diresta, Chiara, Volonteri, Chiara, Castiglioni, Emanuela, Bonfiglio, Silvia, Lazarevic, Dejan, Cittaro, Davide, Stupkad, Elia, Ferrari, Maurizio, Somaschini, Marco, Magaldi, Rosario, Rinaldi, Matteo, Maffei, Gianfranco, Stronati, Mauro, Tzialla, Chryssoula, Borghesi, Alessandro, Tagliabue, Paolo, Fedeli, Tiziana, Citterio, Marco, Mosca, Fabio, Colnaghi, Mariarosa, Lavizzari, Anna, Agosti, Massimo, Francescato, Gaia, Pomero, Giulia, Dalmazzo, Cristina, Boldrini, Antonio, Scaramuzzo, Rosa, Bertino, Enrico, Borgione, Silvia, Martano, Claudio, Carnielli, Virgilio, Nobile, Stefano, Auriemma, Antonietta, Bellan, Cristina, Carrera, Giuseppe, Zambetti, Chiara, Pucello, Riccardo, Palatta, Sara, Stefano Nobile (ORCID:0000-0002-5304-1485), Carrera, Paola, Diresta, Chiara, Volonteri, Chiara, Castiglioni, Emanuela, Bonfiglio, Silvia, Lazarevic, Dejan, Cittaro, Davide, Stupkad, Elia, Ferrari, Maurizio, Somaschini, Marco, Magaldi, Rosario, Rinaldi, Matteo, Maffei, Gianfranco, Stronati, Mauro, Tzialla, Chryssoula, Borghesi, Alessandro, Tagliabue, Paolo, Fedeli, Tiziana, Citterio, Marco, Mosca, Fabio, Colnaghi, Mariarosa, Lavizzari, Anna, Agosti, Massimo, Francescato, Gaia, Pomero, Giulia, Dalmazzo, Cristina, Boldrini, Antonio, Scaramuzzo, Rosa, Bertino, Enrico, Borgione, Silvia, Martano, Claudio, Carnielli, Virgilio, Nobile, Stefano, Auriemma, Antonietta, Bellan, Cristina, Carrera, Giuseppe, Zambetti, Chiara, Pucello, Riccardo, Palatta, Sara, and Stefano Nobile (ORCID:0000-0002-5304-1485)

Abstract

Background: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infancy, affecting preterm children with low birth weight. The disease has a multifactorial aetiology with a significant genetic component; until now published association studies have identified several candidate genes but only few of these data has been replicated. In this pilot study, we approached exome sequencing aimed at identifying non-common variants, which are expected to have a stronger phenotypic effect. Materials and methods: We performed this study on 26 Italian severely affected BPD preterm unrelated newborns, homogeneously selected from a large prospective cohort. We used an Illumina HiSeq 2000 for sequencing. Data analysis was focussed on genes previously associated to BPD susceptibility and to new candidates in related pathways, highlighted by a prioritization analysis performed using ToppGene Suite. Results: By exome sequencing, we identified 3369 novel variants, with a median of 400 variations per sample. The top candidate genes highlighted were NOS2, MMP1, CRP, LBP and the toll-like receptor (. TLR) family. All of them have been confirmed with Sanger sequencing. Conclusions: Potential candidate genes have been discovered in this preliminary study; the pathogenic role of identified variants will need to be confirmed with functional and segregation studies and possibly with further methods, able to evaluate the collective influence of rare variants.Moreover, additional candidates will be tested and genetic analysis will be extended to all affected children.

Published
2015

37. Exome sequencing and pathway analysis for identification of genetic variability relevant for bronchopulmonary dysplasia (BPD) in preterm newborns: A pilot study

Author

Carrera, Paola, primary, Di Resta, Chiara, additional, Volonteri, Chiara, additional, Castiglioni, Emanuela, additional, Bonfiglio, Silvia, additional, Lazarevic, Dejan, additional, Cittaro, Davide, additional, Stupka, Elia, additional, Ferrari, Maurizio, additional, Somaschini, Marco, additional, Magaldi, Rosario, additional, Rinaldi, Matteo, additional, Maffei, Gianfranco, additional, Stronati, Mauro, additional, Tzialla, Chryssoula, additional, Borghesi, Alessandro, additional, Tagliabue, Paolo, additional, Fedeli, Tiziana, additional, Citterio, Marco, additional, Mosca, Fabio, additional, Colnaghi, Mariarosa, additional, Lavizzari, Anna, additional, Agosti, Massimo, additional, Francescato, Gaia, additional, Pomero, Giulia, additional, Dalmazzo, Cristina, additional, Boldrini, Antonio, additional, Scaramuzzo, Rosa, additional, Bertino, Enrico, additional, Borgione, Silvia, additional, Martano, Claudio, additional, Carnielli, Virgilio, additional, Nobile, Stefano, additional, Auriemma, Antonietta, additional, Bellan, Cristina, additional, Carrera, Giuseppe, additional, Zambetti, Chiara, additional, Pucello, Riccardo, additional, and Palatta, Sara, additional

Published
2015
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39. Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI): a feasibility study.

Author

Filippi, Luca, Fiorini, Patrizio, Catarzi, Serena, Berti, Elettra, Padrini, Letizia, Landucci, Elisa, Donzelli, Gianpaolo, Bartalena, Laura, Fiorentini, Erika, Boldrini, Antonio, Giampietri, Matteo, Scaramuzzo, Rosa Teresa, la Marca, Giancarlo, Della Bona, Maria Luisa, Fiori, Simona, Tinelli, Francesca, Bancale, Ada, Guzzetta, Andrea, Cioni, Giovanni, and Pisano, Tiziana

Subjects
COMPARATIVE studies, FRUCTOSE, INDUCED hypothermia, MAGNETIC resonance imaging, RESEARCH methodology, MEDICAL cooperation, NEURORADIOLOGY, RESEARCH, PILOT projects, EVALUATION research, RANDOMIZED controlled trials, TREATMENT effectiveness, CEREBRAL anoxia-ischemia, NEUROPROTECTIVE agents, THERAPEUTICS
Abstract

Purpose: To investigate the feasibility of a study based on treatment with topiramate (TPM) added to moderate hypothermia in newborns with hypoxic ischemic encephalopathy (HIE).Materials and Methods: Multicenter randomized controlled trial. Term newborns with precocious metabolic, clinical and electroencephalographic (EEG) signs of HIE were selected according to their amplified integrated EEG pattern and randomized to receive either TPM (10 mg/kg once a day for the first three days of life) plus moderate hypothermia or hypothermia alone. Safety was assessed by monitoring cardiorespiratory parameters and blood samples collected to check renal, liver, metabolic balance and TPM pharmacokinetics. Efficacy was evaluated by the combined frequency of mortality and severe neurological disability as primary outcome. Incidence of magnetic resonance injury, epilepsy, blindness, hearing loss, neurodevelopment at 18-24 months of life was assessed as secondary outcomes.Results: Forty-four asphyxiated newborns were enrolled in the study. Twenty one newborns (10 with moderate and 11 with severe HIE) were allocated to hypothermia plus TPM and 23 (12 moderate and 11 severe HIE) to hypothermia. No statistically or clinically significant differences were observed for safety, primary or secondary outcomes. However, a reduction in the prevalence of epilepsy was observed in newborns co-treated with TPM.Conclusions: Results of this pilot trial suggest that administration of TPM in newborns with HIE is safe but does not reduce the combined frequency of mortality and severe neurological disability. The role of TPM co-treatment in preventing subsequent epilepsy deserves further studies. [ABSTRACT FROM AUTHOR]

Published
2018
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41. The multicenter Italian birth cohort study on incidence and determinants of lower respiratory tract infection hospitalization in infants at 33 weeks GA or more: preliminary results

Author

Lanari, M, Adorni, F, Silvestri, M, Coscia, A, Musicco, M, 'ITALIAN STUDY GROUP ON RISK FACTORS FOR RSV RELATED HOSPITALIZATION', Boldrini, Antonio, Lanari M., Adorni F., Silvestri M., Coscia A., Musicco M., and Faldella G.

Subjects
Male, Pediatrics, medicine.medical_specialty, Gestational Age, Pilot Projects, Infant, Premature, Diseases, VRS, preterm infant, Cohort Studies, Risk Factors, Lower respiratory tract infection, medicine, Humans, Respiratory system, Respiratory Tract Infections, Respiratory tract infections, business.industry, Incidence (epidemiology), Incidence, Respiratory disease, Infant, Newborn, Parturition, Obstetrics and Gynecology, Gestational age, medicine.disease, Hospitalization, Italy, Pediatrics, Perinatology and Child Health, Cohort, Female, business, Infant, Premature, Cohort study
Abstract

Background Respiratory syncytial virus (RSV) causes respiratory infections during the first year of life. Very premature infants have more severe diseases and also ‘late preterm infants’ may be more susceptible to the infection. Aim of the study To evaluate in an Italian cohort the incidence and risk factors of severe hospitalized lower respiratory tract infection (LRTI) induced or not by RSV during the first year of life. Methods A cohort of 33 + 0d –34 + 6d wGA newborns paired with two sex- and age-matched 35 + 0d –37 + 6d wGA and ≥ 38 + 0d wGA newborns were enrolled. Hospitalization for LRTI induced or not by RSV during the first year of life was assessed through phone interview at the end of the RSV season (November–March) and at the completion of the first year of life. The parents were asked to report hospitalization for any reason. Results 1064 neonates were enrolled (November 2009–October 2010), 697 had at least one phone follow-up by September 2010. Babies of 33 + 0d –34 + 6d wGA were more frequently conceived through assisted fertilization technologies, born from cesarean delivery had more frequently acute perinatal risk factors and were more frequently twins. After a mean 6 month-follow-up, we registered 29 hospitalizations for LRTI induced or not by RSV. Hospitalizations were slightly and non-significantly more frequent in 33 + 0d –37 + 6d wGA infants. The risk of hospitalization was significantly 60% reduced in breastfed babies and four folds significantly increased during the RSV season. Conclusion The very preliminary data of this ongoing study suggest that in ‘late-preterm’ infants some individual/environmental characteristics of the infants play a relevant role in determining the risk of severe RSV infection.

Published
2011
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43. Simulation on neonatal stabilization and transport

Author

Cuttano, Armando, primary, Scaramuzzo, Rosa T, additional, Moscuzza, Francesca, additional, Panizza, Davide, additional, Ciantelli, Massimiliano, additional, Vuerich, Marco, additional, Sigali, Emilio, additional, and Boldrini, Antonio, additional

Published
2015
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44. A novel simulator for mechanical ventilation in newborns: MEchatronic REspiratory System SImulator for Neonatal Applications

Author

Baldoli, Ilaria, primary, Cuttano, Armando, additional, Scaramuzzo, Rosa T, additional, Tognarelli, Selene, additional, Ciantelli, Massimiliano, additional, Cecchi, Francesca, additional, Gentile, Marzia, additional, Sigali, Emilio, additional, Laschi, Cecilia, additional, Ghirri, Paolo, additional, Menciassi, Arianna, additional, Dario, Paolo, additional, and Boldrini, Antonio, additional

Published
2015
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45. Human saliva as route of inter-human infection for mouse mammary tumor virus

Author

Mazzanti, Chiara Maria, primary, Lessi, Francesca, additional, Armogida, Ivana, additional, Zavaglia, Katia, additional, Franceschi, Sara, additional, Al Hamad, Mohammad, additional, Roncella, Manuela, additional, Ghilli, Matteo, additional, Boldrini, Antonio, additional, Aretini, Paolo, additional, Fanelli, Giovanni, additional, Marchetti, Ivo, additional, Scatena, Cristian, additional, Hochman, Jacob, additional, Naccarato, Antonio Giuseppe, additional, and Bevilacqua, Generoso, additional

Published
2015
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46. Comparative performances analysis of neonatal ventilators

Author

Baldoli, Ilaria, primary, Tognarelli, Selene, additional, Scaramuzzo, Rosa T, additional, Ciantelli, Massimiliano, additional, Cecchi, Francesca, additional, Gentile, Marzia, additional, Sigali, Emilio, additional, Ghirri, Paolo, additional, Boldrini, Antonio, additional, Menciassi, Arianna, additional, Laschi, Cecilia, additional, and Cuttano, Armando, additional

Published
2015
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