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New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat. This thesis is focused on using the in vivo whole animalzebrafish embryo model for TB to evaluate potential anti-TB host-directed therapeutics (HDTs) arising from in vitro screens. Although in vitro screens for HDTs using cellular models can be performed at high throughput, a limiting step is the validation in whole animal models and translation of results to clinical applications. Due to the complex infection dynamics of mycobacteria, the use of whole animal models is indispensable in research into TB and the zebrafish model has contributed key findings about host-pathogen dynamics during mycobacterial infection. One of the most promising host targets of HDTs is autophagy, which is recognized as an important host-protective pathway. Boosting autophagy levels using HDTs could be a way to overcome the pathogen’s autophagy evasion strategies and could therefore be a promising therapeutic route. For this thesis we took advantage of the possibilities of the zebrafish embryo model for TB and the zebrafish toolkit to study several autophagy-modulating HDTs as potential anti-TB drugs.

AGL is a system for group management training that operates without the direct intervention of an instructor. This article discusses how the "educational mix" for the AGL system was developed. (Author/STS)

2nd International Colloquium on Tourism and Leisure, Chiang Mai, Thailand 5-8th May 2008 Opportunities and Challenges: The 1st International Cruise Conference Bremerhaven, Germany 26 – 27 Sept 2008 The 2nd ITSA Biennial Conference Globalization, Tourism and Development: Mega Events and Urban Tourism, Shanghai The 4th World Conference for Graduate Research in Tourism, Hospitality and Leisure – Antalya, Turkey, 22-27 April 2008