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8. Bone impairment in primary hyperoxaluria: a review

Author

Bacchetta, Justine, Boivin, Georges, and Cochat, Pierre

Subjects
Hyperoxaluria -- Complications and side effects -- Research, Bone diseases -- Risk factors -- Research, Health
Abstract

Deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria (PH). Since the bone compartment can store massive amounts of oxalate, patients present with recurrent low-trauma fractures, bone deformations, severe bone pains, and specific oxalate osteopathy on X-ray. Bone biopsy from the iliac crest displays specific features such as oxalate crystals surrounded by a granulomatous reaction corresponding to an invasion of bone surface by macrophages. The objective of this manuscript is therefore to provide an overview of bone impairment in PH, by reviewing the current literature on bone and dental symptoms as well as imaging techniques used for assessing bone disease., Author(s): Justine Bacchetta[sup.1] [sup.2] [sup.3] [sup.4] , Georges Boivin[sup.2] [sup.3] , Pierre Cochat[sup.1] [sup.3] Author Affiliations: (1) Service de Nephrologie, Rhumatologie et Dermatologie Pediatriques, Centre de Reference des Maladies Renales [...]

Published
2016
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12. Inactivation of Osteoblast PKC Signaling Reduces Cortical Bone Mass and Density and Aggravates Renal Osteodystrophy in Mice with Chronic Kidney Disease on High Phosphate Diet

Author

Zaloszyc, Ariane, primary, Choquet, Philippe, additional, Sayeh, Amira, additional, Bartosova, Maria, additional, Schaefer, Betti, additional, Huegel, Ulrike, additional, Aubertin-Kirch, Gaëlle, additional, Healy, Christopher, additional, Severac, François, additional, Rizzo, Sébastien, additional, Boivin, Georges, additional, Schaefer, Franz, additional, Fischbach, Michel, additional, Bacchetta, Justine, additional, Bahram, Seiamak, additional, and Schmitt, Claus Peter, additional

Published
2022
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21. Variables Reflecting the Mineralization of Bone Tissue From Fracturing Versus Nonfracturing Postmenopausal Nonosteoporotic Women

Author

Rizzo, Sébastien, Farlay, Delphine, Akhter, Mohammed, Boskey, Adele, Recker, Robert, Lappe, Joan, and Boivin, Georges

Subjects
HETEROGENEITY OF MINERALIZATION, DIGITIZED MICRORADIOGRAPHY, NONFRACTURING POSTMENOPAUSAL WOMEN, FRACTURING POSTMENOPAUSAL WOMEN, Original Article, DEGREE OF MINERALIZATION, Original Articles
Abstract

Women with equivalent areal bone mineral densities may show a different fracture incidence due to differences in bone intrinsic quality. Previously, Fourier transform infrared spectroscopic imaging (FTIRI) on the same iliac bone biopsies reported here, showed that the only significantly different variable was the carbonate/phosphate ratio, which was decreased in the fracturing group. Nanoindentation showed that fracturing bone was less mechanically heterogeneous than nonfracturing bone and could propagate damage (microcracks) more easily. The hypothesis is that fracturing women have reduced mineralization of bone tissue compared to nonfracturing women. Transiliac bone biopsies were collected from fracturing (n = 60, 62.5 ± 7.4 years old) and nonfracturing (n = 60, 62.3 ± 7.3 years old) postmenopausal women, to assess the mineralization of bone tissue using digitized microradiography. The degree of mineralization of bone (DMB, g/cm3) and the heterogeneity index (HI, g/cm3) of the DMB were calculated for cancellous (canc), cortical (cort) and total bone. Results were compared to variables from nanoindentation, FTIRI, and histomorphometry. DMB and HI were not significantly different between fracturing and nonfracturing groups. In the nonfracturing group, cort and canc HI were weakly negatively associated with cort and canc DMB (r′ = −0.388, p

Published
2018

23. Duration‐Dependent Increase of Human Bone Matrix Mineralization in Long‐Term Bisphosphonate Users with Atypical Femur Fracture

Author

Farlay, Delphine, primary, Rizzo, Sébastien, additional, Ste‐Marie, Louis‐Georges, additional, Michou, Laëtitia, additional, Morin, Suzanne N, additional, Qiu, Shijing, additional, Chavassieux, Pascale, additional, Chapurlat, Roland D, additional, Rao, Sudhaker D, additional, Brown, Jacques P, additional, and Boivin, Georges, additional

Published
2021
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28. Soft Tissue and Marginal Bone Adaptation on Platform-Switched Implants with a Morse Cone Connection: A Histomorphometric Study in Dogs.

Author

Bolle, Caroline, Gustin, Marie-Paule, Fau, Didier, Boivin, Georges, Exbrayat, Patrick, and Grosgogeat, Brigitte

Subjects
ALVEOLAR process surgery, ANALYTICAL biochemistry, ANIMAL experimentation, COLLECTION & preservation of biological specimens, BIOPSY, BONE resorption, DENTAL materials, DOGS, EPITHELIUM, EXPERIMENTAL design, HISTOLOGY, DENTAL implants, MANDIBLE, MICROSCOPY, ORAL surgery, PROBABILITY theory, PROSTHETICS, RESEARCH funding, TITANIUM, WOUND healing, DATA analysis software, DESCRIPTIVE statistics
Abstract

The purpose of this study was to investigate peri-implant tissue adaptation on platform-switched implants with a Morse cone-type connection, after 3 and 12 weeks of healing in dogs. Ten weeks after mandibular premolar extractions, eight beagle dogs received three implants each. At each biopsy interval, four animals were sacrificed and biopsies were processed for histologic analysis. The height of the peri-implant mucosa was 2.32 mm and 2.88 mm, respectively, whereas the bone level in relation to the implant platform was -0.39 mm and -0.67 mm, respectively, after 3 and 12 weeks of healing. Within the limits of the present study, platform-switched implants exhibited reduced values of biologic width and marginal bone loss when compared with previous data. [ABSTRACT FROM AUTHOR]

Published
2016
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34. Is cortical porosity associated with degraded material quality?

Author

Gourrier, Aurelien, Farlay, Delphine, Helene Follet, Boivin, Georges, Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018
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35. Validation of a novel microradiography device for characterization of bone mineralization

Author

Kaftandjian, Valérie, Follet, Hélène, Montagner, Florian, Kaftandjian, Valerie, Farlay, Delphine, Brau, Daniel, Boivin, Georges, Follet, Helene, Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Vibrations Acoustique (LVA), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon, Photonic Science, Photonic Science Ltd, ANR-11-BS09-0032,MALICE,Analyse multiéchelle de la croissance osseuse chez l'enfant : une approche conjointe par imagerie ultrasonore et une modélisation biomécanique(2011), ANR-11-IDEX-0007,Avenir L.S.E.,Lyon Acoustics Centre(2011), Controle Non Destructif par Rayonnements Ionisants (CNDRI), Ostéoporose et Qualité osseuse (Site Laennec), Université de Lyon-Université de Lyon-IFR62-Institut National de la Santé et de la Recherche Médicale (INSERM), and Physiopathologie des Osteopathies Fragilisantes

Subjects
contrast to noise ratio, Computer science, Image quality, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Magnification, 030209 endocrinology & metabolism, Ilium, [SPI]Engineering Sciences [physics], 03 medical and health sciences, Calcification, Physiologic, 0302 clinical medicine, Optics, Contrast-to-noise ratio, Humans, Radiology, Nuclear Medicine and imaging, Computer vision, Electrical and Electronic Engineering, spatial resolution, Instrumentation, Image resolution, 030304 developmental biology, 0303 health sciences, Radiation, digital detector, business.industry, quantitative microradiography, Detector, Resolution (electron density), Reproducibility of Results, Signal Processing, Computer-Assisted, Condensed Matter Physics, Real image, Microradiography, Sample (graphics), Mineralization of bone, Artificial intelligence, business
Abstract

International audience; In order to simplify bone mineralization measurements, a system using radiographic films has been updated with a 13 digital detector. The objective of this paper was to validate this new device. Technologies and physical phenomena involved 14 in both systems (radiographic films and digital detector) are different. The methodology used to compare the two systems was 15 based on image quality and assessed on two main parameters: contrast to noise ratio and spatial resolution. Results showed 16 that the contrast to noise ratio was similar between the two systems, provided that acquisition parameters were optimized. With 17 regard to spatial resolution, a magnification factor of at least 4 or more was required to achieve the same resolution as films. 18 A final validation was also shown on a real image of a bone sample. The results showed that both systems have similar image 19 quality performances, and the system using digital detector has several advantages (easier to use than films, no consumables 20 and faster acquisition time).

Published
2015
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37. Label-free imaging of bone multiscale porosity and interfaces using third-harmonic generation microscopy

Author

Genthial, Rachel, primary, Beaurepaire, Emmanuel, additional, Schanne-Klein, Marie-Claire, additional, Peyrin, Françoise, additional, Farlay, Delphine, additional, Olivier, Cécile, additional, Bala, Yohann, additional, Boivin, Georges, additional, Vial, Jean-Claude, additional, Débarre, Delphine, additional, and Gourrier, Aurélien, additional

Published
2017
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39. Early Periimplant Tissue Healing on 1-Piece Implants With a Concave Transmucosal Design

Author

Bolle, Caroline, Gustin, Marie-Paule, Fau, Didier, Exbrayat, Patrick, Boivin, Georges, Grosgogeat, Brigitte, Laboratoire des Multimatériaux et Interfaces (LMI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 - UFR d'Odontologie (UR1 Odontologie), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Hospices Civils de Lyon (HCL), Institut des Sciences Pharmaceutiques et Biologiques (ISPB), Université de Lyon-Université de Lyon, Interactions Cellules Environnement - UR (ICE), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), UFR d’Odontologie, Université de Lyon, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes - UFR d'Odontologie (UR Odontologie), and Université de Rennes (UR)

Subjects
dental implant, [SDV.BA]Life Sciences [q-bio]/Animal biology, narrow transmucosal design, biological width, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, histomorphometry
Abstract

International audience; Introduction: The purpose of our study was to investigate the early healing phase of marginal bone and soft tissues around unloaded 1-piece implants with a concave transmucosal design, in a dog model.Methods: Twenty-four 1-piece implants with a concave transmucosal neck were inserted 1 mm subcrestally in the mandibular ridge of 8 beagle dogs. Four animals were sacrificed after 3 and 12 weeks of healing. Histomorphometric analysis was performed to measure the height of the periimplant tissues.Results and Discussion: The overall height of the periimplant mucosa was, respectively, 2.67 and 2.52 mm, after 3 and 12 weeks. In the connective tissue, a soft tissue O-ring seal was observed in the healing area provided by the transmucosal concavity, after 12 weeks. The location of the first bone-to-implant contact facing the implant shoulder was 0.00 and +0.18 mm, respectively, after 3 and 12 weeks of healing. Some bone apposition occurred on the implant shoulder during the healing.Conclusion: Within the limits of the present study, a concave transmucosal design in 1-piece implants was associated with a short vertical value of biological width and promoted a mechanical interlocking of the implant body at the connective tissue and marginal bone levels.

Published
2015
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40. Ridge Reconstruction After Implant Failure Using a Resorbable Membrane: Report of a Case and Histologic Study.

Author

Godefroy, Jean-Noël, Laroche, Norbert, Fourcart, Jean, and Boivin, Georges

Subjects
DENTAL implants, BONE resorption, BONE diseases, GUIDED tissue regeneration, COLLAGEN, HISTOLOGY
Abstract

Implant failures often give rise to significant bone resorption, which can jeopardize future implantation and cause esthetic and functional problems. One technique now commonly accepted is guided tissue augmentation (GTA) prior to reimplantation. A resorbable collagen membrane clinically tested for 3 years has provided predictable results both in GTA and in guided tissue regeneration (GTR). This article reports a study at 3 and 6 months after use of this collagen membrane in ridge repair. New bone formation, first woven in texture, then lamellar, was observed. Resorbable collagen membranes can provide for ridge enlargement and bone repair without inflammation during healing. [ABSTRACT FROM AUTHOR]

Published
1994

41. Autophagy in osteoblasts is involved in mineralization and bone homeostasis

Author

Nollet, Marie, Santucci-Darmanin, Sabine, Breuil, Véronique, Al-Sahlanee, Rasha, Cros, Chantal, Topi, Majlinda, Momier, David, Samson, Michel, Pagnotta, Sophie, Cailleteau, Laurence, Battaglia, Séverine, Farlay, Delphine, Dacquin, Romain, Barois, Nicolas, Jurdic, Pierre, Boivin, Georges, Heymann, Dominique, Lafont, Frank, Lu, Shi Shou, Dempster, David, Carle, Georges, Pierrefite-Carle, Valérie, Carle, Pierre, Transporteurs et Imagerie, Radiothérapie en Oncologie et Mécanismes biologiques des Altérations du Tissu Osseux (TIRO-MATOs - UMR E4320), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-UMR E4320 (TIRO-MATOs), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA), Centre Commun de Microscopie Appliquée (CCMA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), UMR E4320 (TIRO-MATOs), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Côte d'Azur (UCA)-Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
collagen, HRTEM, high resolution transmission electron microscopy, [SDV]Life Sciences [q-bio], Osteoporosis, bone volume, Osteoclasts, TNFSF11/RANKL, runt-related transcription factor 2, TV, Bone remodeling, Mice, Homeostasis, tumor necrosis factor (ligand) superfamily, mineralization, PBS, ComputingMilieux_MISCELLANEOUS, total volume, Microscopy, Confocal, biology, Osteoblast, BECN1, Beclin 1, tartrate resistant, autophagy-related, Cell biology, ACP5/TRAP, medicine.anatomical_structure, RANKL, osteoclast, osteoblast, Female, ribonucleic acid, secreted phosphoprotein 1, medicine.medical_specialty, autophagy, Basic Research Papers, RUNX2, Green Fluorescent Proteins, acid phosphatase 5, Mice, Transgenic, type I, phosphate-buffered saline, Bone and Bones, Bone resorption, SAED, member 11, Osteoclast, Cell Line, Tumor, Internal medicine, bafilomycin A1, medicine, Animals, BV, OC, selected area electron diffraction, OB, Baf, Bone Resorption, Molecular Biology, bone remodeling, microtubule-associated protein 1 light chain 3, Osteoblasts, RANK Ligand, Autophagy, NF-kappa B p50 Subunit, α 1, X-Ray Microtomography, Cell Biology, MAP1LC3 (LC3), medicine.disease, Rats, Oxidative Stress, Endocrinology, TUBB, tubulin, SPP1/OPN, Col1A, biology.protein, RNA, beta
Abstract

International audience; Bone remodeling is a tightly controlled mechanism in which osteoblasts (OB), the cells responsible for bone formation, osteoclasts (OC), the cells specialized for bone resorption, and osteocytes, the multifunctional mechanosensing cells embedded in the bone matrix, are the main actors. Increased oxidative stress in OB, the cells producing and mineralizing bone matrix, has been associated with osteoporosis development but the role of autophagy in OB has not yet been addressed. This is the goal of the present study. We first show that the autophagic process is induced in OB during mineralization. Then, using knockdown of autophagy-essential genes and OB-specific autophagy-deficient mice, we demonstrate that autophagy deficiency reduces mineralization capacity. Moreover, our data suggest that autophagic vacuoles could be used as vehicles in OB to secrete apatite crystals. In addition, autophagy-deficient OB exhibit increased oxidative stress and secretion of the receptor activator of NFKB1 (TNFSF11/RANKL), favoring generation of OC, the cells specialized in bone resorption. In vivo, we observed a 50% reduction in trabecular bone mass in OB-specific autophagy-deficient mice. Taken together, our results show for the first time that autophagy in OB is involved both in the mineralization process and in bone homeostasis. These findings are of importance for mineralized tissues which extend from corals to vertebrates and uncover new therapeutic targets for calcified tissue-related metabolic pathologies.

Published
2014
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42. Validation of a digital system of microradiography for the characterization of bone mineralization

Author

Montagner, Florent, Kaftandjian, Valérie, Farlay, Delphine, Brau, Daniel, Boivin, Georges, Follet, Hélène, Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Vibrations Acoustique (LVA), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014
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43. Mandibular reconstructed bone quality after filling of defects with dental bone substitutes in beagles

Author

Rizzo , Sebastien, Baptista , Augusto Andre, Burt-Pichat , Brigitte, Rondot , Capucine, Alves , Antoine, Wittmann , Catherine, Gagnieu , Christian, Forest , Patricia, Boivin , Georges, Bernard , Jean-Pierre, Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases ( LYOS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Ostéoporose et Qualité osseuse (Site Laennec), Université de Lyon-Université de Lyon-IFR62-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Biom'up, Matériaux, ingénierie et science [Villeurbanne] ( MATEIS ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ) -Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Université de Lyon-IFR62-Institut National de la Santé et de la Recherche Médicale (INSERM), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Mateis, Laboratoire

Subjects
[ SPI.MAT ] Engineering Sciences [physics]/Materials, [SPI.MAT] Engineering Sciences [physics]/Materials, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Houston, TX, SEP 12-15, 2014; International audience

Published
2014

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