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Today, the number of neuropathy patients is growing steadily due to the active development of the technosphere. In fact, extrafocal neuropathy reflects reactions in response to stressful situations and the development of functional disorders in all parenchymal organs as a result of these factors. The research aims to develop a differentiated approach to correcting functional disorders of the parotid glands in patients with elevated psychological responses. Objects and methods of the research. Depending on the intensity of neurogenic salivary adenitis (NSA) clinical signs, the studied patients were divided into 3 groups: group I – patients with mild NSA (44 persons); group II – patients with moderate degree (48 people); group III – patients with severe NSA (21 people). All patients observed hygiene and performed oral cavity sanitation at the dentist’s office. Patients with mild NSA received the following set of treatments: daily bougieurage of ducts of the studied glands for 5 days, massaging them for 5 minutes before and after meals over the course of 5-7 days. Due to increased anxiety patients were additionally prescribed a twoweek course of Persen-forte. They were also prescribed a 5-day course of Drotaverine to relieve the spasm of duct apparatus of the parotid glands in the dosage of 1 pill 3 times a day to be taken 20 minutes before meals. Patients with moderate NSA underwent a 5-7 day course of daily duct bougieurage and 5-minute massage of the studied glands before and after meals. Additionally, ectericide was daily instilled into the ducts of the affected glands over the course of 5-7 days and galvanization of the affected gland areas №5. There were prescribed a 3-week course of Persen-forte, a 7-day course of Drotaverine, and a 14-day course of retinol acetate in the dosage of 5000 IU 1 time per day. All patients with severe NSA were prescribed: daily bougieurage of ducts for 5 days, massaging them for 5 minutes before and after meals over the course of 7-10 days, 5 procedures of ectericide and trypsin instillation into the ducts of the studied glands every other day, gland electrophoresis with 5% ascorbic acid solution № 5. There were prescribed a 4-week course of Persen-forte and a 10-day course of Drotaverine. A complex multivitamin drug Quadevit Active was prescribed in the dosage of 1 pill per day for 1 month. Results of the research. The analysis of treatment outcomes of NSA patients who applied a set of treatment and prevention measures aimed at improving the functional state of the salivary glands and stabilizing oral homeostasis, showed that among 44 patients with mild NSA, 40 patients (90, 91%) have recovered and 4 subjects (9.09%) have improved their condition. This was confirmed by the results of research-specific and specialized studies. Cytological examination of the smears of the affected parotid glands’ secretion revealed a small number of squamous epithelial cells and single neutrophilic leukocytes, which was close to normal. Determining the level of anxiety according to the Taylor Manifest Anxiety Scale (TMAS) in patients with mild NSA found low values of 1.53±0.05 points in 19 people and medium values of 9.27±0.05 points in 3 patients, which signifies decreased anxiety rates in most patients. Of the 48 patients with a moderate severity of the disease, 35 patients (72.91%) have recovered, 11 subjects (22.92%) have improved and 2 people (4.17%) have not changed their condition. Physicochemical parameters of oral fluid and parotid gland secretion were normalized. Cytological examination of the studied parotid gland secretion revealed an increased number of neutrophilic leukocytes, individual lymphoid cells, macrophages, cylindrical epithelial cells. The sialographic picture of parotid glands revealed no abnormalities in only 3 people. In 6 patients, there were various narrowings of the main duct, I-II-III order ducts, bulbous and spherical ectasias of II-V order ducts, impaired filling of II-V order ducts due to almost the entire gland volume being narrowed, which was accompanied by individual sialectasis (3 patients). The level of anxiety tended to decrease. Out of 21 patients with severe NSA, recovery was noted in 13 (61.91%), improvement in 6 (28.57%), and unchanged condition in 2 (9.52%). Cell composition was not numerous according to cytological examination of the parotid gland secretion in 8 people with severe NSA, occasional cells of squamous epithelium have been registered in the samples, as well as sporadic cylindrical epithelium cells with altered structure. A small amount of mucus, reticuloendothelial cells, single macrophages, groups of lymphocytes were noted in 4 patients. Sialography performed on 5 patients revealed unchanged duct system in 3 patients and the presence of II-V order duct narrowing in 2 subjects, as well as some sialectases. Determination of the level of anxiety revealed that 9 people had low values of 2.18±0.05 points and 3 patients had medium values (8.67±0.05 points), which reflects a decrease in anxiety rates in most patients. Thus, the treatment and prevention programs that were prescribed to NSA patients caused the anatomical and functional changes of the parotid glands in the affected salivary glands in most patients, as well as improving the general somatic condition of patients.

Biofilm microorganisms cause about 80% of chronic infections, leading to increased morbidity, increased hospital stays and enhanced health care costs. Biofilms can also grow on abiotic surfaces, including orthopedic prostheses, stents, and catheters. Antibiotics are not effective enough to treat biofilm infections, and antibiofilm agents are being sought among other classes of compounds, in particular antioxidants, including the well-known drug ethylmethylhydroxypyridine succinate (mexidol). The aim of the research was to study the effect of mexidol on the formation of biofilms by test strains of microorganisms. Clinical strains of bacteria (E. coli 311, P. aeruginosa 449, S. aureus 222) and fungi (C. albicans 1486) were used. The antimicrobial activity of mexidol was determined by serial dilutions in liquid media in the concentration range of 1.5-200 μg/ml. Determination of the microorganisms ability to form biofilm was performed according to the known O’Toole method. A degree of the biofilm formation intensity was determined as described by Stepanovic S. et al. The potential antibiofilm activity of mexidol was studied at concentrations of 5–200 μg/ml. Statistical processing of the results was performed using Newman-Keuls criterion by the software StatSoft Statistica 6.0. It was shown that for planktonic forms of E. coli, P. aeruginosa, S. aureus, and C. albicans, the minimum inhibitory concentration of mexidol is more 200 μg/ml. E. coli 311 and P. aeruginosa 449 show a strong ability to form biofilms, S. aureus 222 – the medium ability. C. albicans 1486 does not adhere to the abiotic surface and was no longer used. Mexidol enhances the biofilm production by E. coli 311, increasing the biomass of biofilms by 12–15%. The drug increases the biomass of P. aeruginosa biofilms by 33–110% against control, and this is most pronounced at the minimum concentration of the drug. Mexidol also stimulates the formation of S. aureus 222 biofilms by 2.1-2.7 times compared to the control. Therefore, under the action of the drug at subinhibitory concentrations, stimulation of the biofilm formation by gram-negative (E. coli 311, P. aeruginosa 449) and gram-positive bacteria (S. aureus 222) is observed. The identifiedability of mexidol to stimulate biofilm formation requires further research to assess the feasibility of its use in the complex therapy of purulent-inflammatory diseases.

Introduction. The modern development of Ukrainian medicine in the context of global trends and perceptions of a human, their life as the major value, requires the creation and implementation of a quality system for continuous education of a harmonious personality of a future specialist, who is characterized not only by deep knowledge in the field of medical and theoretical, clinical, chemical and pharmaceutical disciplines, but also a diverse general culture, awareness of universal, national and state priorities. The aim of this article is to determine the essence and main tasks for the effective functioning of the system of educational work in higher education at the current level of development of society. Research results and their discussion. It is the teacher’s duty not only to provide medical students with the skills of practical work, but also to form in them a worldview inherent in a comprehensively educated, harmoniously developed personality with a high level of public conscience and universal values. First of all, it is about fostering respect, compassion for the patient, awareness of the value of human life. At the same time, student volunteering in such areas as health care, ecology, social protection of humans and animals, etc., can be considered as one of the components in the professional training of future physicians. The future doctor is not only a competent specialist, but also a conscious citizen who upholds the democratic values and moral norms established in the mentality of their people, ready to work for the prosperity of their country, strengthening its authority. Therefore, considerable attention in educational work, certainly, should be paid to the formation of national consciousness in young men and women, deep patriotic feelings and beliefs, devotion to the Motherland, responsibility for its fate, protection, development of historical memory. Admitting the great importance of educational work in the training of highly qualified specialists, the administration of Poltava State Medical University considers it an integral component of the overall educational process. In recent years, it has become systematically complex and clearly organized. Traditional events, such as celebrations of public holidays, significant dates in the history of the university, meetings with prominent people, famous doctors, thematic meetings, memorial events are complemented by new forms that take into account the interests and preferences of modern youth. Thus, students willingly participate in various flash mobs – mass actions organized through social networks, aimed at forming patriotic feelings, civic qualities, involvement in the philanthropic activity of future doctors. Increasingly, educational activities take the form of trainings, challenges of socially significant, professional, charitable orientation. The significant educational influence was the participation of the volunteer team of PSMU «Unity» and volunteer teams operating at the departments of the Faculty of Dentistry, in All-Ukrainian projects and events initiated by volunteers themselves. Every teacher in higher education should be involved in a large range of activities, including the educational component of the training process, and the group sponsor has a special responsibility. It is the group sponsor who needs to take care of providing an individual approach to educational work with students, which should take into account differences in their social and financial status, national characteristics, living conditions, values and so on. Conclusion. Currently, our state is going through a difficult period of its formation, development and establishment. The success of this process largely depends on the spiritual potential of the nation, civic responsibility, and high moral qualities of the younger generation. This necessitates a more practical integration of the educational component into the modern training process at universities.